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  • 1
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    Sustainability, Vol. 11, Pages 4202: Scientific Decision Framework for Evaluation of Renewable Energy Sources under Q-Rung Orthopair Fuzzy Set with Partially Known Weight Information (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: As an attractive generalization of the intuitionistic fuzzy set (IFS), q-rung orthopair fuzzy set (q-ROFS) provides the decision makers (DMs) with a wide window for preference elicitation. Previous studies on q-ROFS indicate that there is an urge for a decision framework which can make use of the available information in a proper manner for making rational decisions. Motivated by the superiority of q-ROFS, in this paper, a new decision framework is proposed, which provides scientific methods for multi-attribute group decision-making (MAGDM). Initially, a programming model is developed for calculating weights of attributes with the help of partially known information. Later, another programming model is developed for determining the weights of DMs with the help of partially known information. Preferences from different DMs are aggregated rationally by using the weights of DMs and extending generalized Maclaurin symmetric mean (GMSM) operator to q-ROFS, which can properly capture the interrelationship among attributes. Further, complex proportional assessment (COPRAS) method is extended to q-ROFS for prioritization of objects by using attributes’ weight vector and aggregated preference matrix. The applicability of the proposed framework is demonstrated by using a renewable energy source prioritization problem from an Indian perspective. Finally, the superiorities and weaknesses of the framework are discussed in comparison with state-of-the-art methods.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI
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  • 2
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    Symmetry, Vol. 11, Pages 2: Probabilistic Linguistic Preference Relation-Based Decision Framework for Multi-Attribute Group Decision Making (2018)
    MDPI
    In: Symmetry
    Details
    Publication Date: 2018
    Description: With trending competition in decision-making process, linguistic decision-making is gaining attractive attention. Previous studies on linguistic decision-making have neglected the occurring probability (relative importance) of each linguistic term which causes unreasonable ranking of objects. Further, decision-makers’ (DMs) often face difficulties in providing apt preference information for evaluation. Motivated by these challenges, in this paper, we set our proposal on probabilistic linguistic preference relation (PLPR)-based decision framework. The framework consists of two phases viz., (a) missing value entry phase and (b) ranking phase. In phase (a), the missing values of PLPR are filled using a newly proposed automatic procedure and consistency of PLPR is ensured using a consistency check and repair mechanism. Following this, in phase (b), objects are ranked using newly proposed analytic hierarchy process (AHP) method under PLPR context. The practicality of the proposal is validated by using two numerical examples viz., green supplier selection problem for healthcare and the automobile industry. Finally, the strength and weakness of the proposal are discussed by comparing with similar methods.
    Electronic ISSN: 2073-8994
    Topics: Mathematics
    Published by MDPI
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  • 3
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    Mathematics, Vol. 7, Pages 342: Interval-Valued Probabilistic Hesitant Fuzzy Set Based Muirhead Mean for Multi-Attribute Group Decision-Making (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: As a powerful generalization to fuzzy set, hesitant fuzzy set (HFS) was introduced, which provided multiple possible membership values to be associated with a specific instance. But HFS did not consider occurrence probability values, and to circumvent the issue, probabilistic HFS (PHFS) was introduced, which associates an occurrence probability value with each hesitant fuzzy element (HFE). Providing such a precise probability value is an open challenge and as a generalization to PHFS, interval-valued PHFS (IVPHFS) was proposed. IVPHFS provided flexibility to decision makers (DMs) by associating a range of values as an occurrence probability for each HFE. To enrich the usefulness of IVPHFS in multi-attribute group decision-making (MAGDM), in this paper, we extend the Muirhead mean (MM) operator to IVPHFS for aggregating preferences. The MM operator is a generalized operator that can effectively capture the interrelationship between multiple attributes. Some properties of the proposed operator are also discussed. Then, a new programming model is proposed for calculating the weights of attributes using DMs’ partial information. Later, a systematic procedure is presented for MAGDM with the proposed operator and the practical use of the operator is demonstrated by using a renewable energy source selection problem. Finally, the strengths and weaknesses of the proposal are discussed in comparison with other methods.
    Electronic ISSN: 2227-7390
    Topics: Mathematics
    Published by MDPI
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  • 4
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    Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-11
    Description: Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with significant apoptosis, very few apoptotic cells are detectable. This is thought to be due to the release of 'find-me' signals by apoptotic cells that recruit motile phagocytes such as monocytes, macrophages and dendritic cells, leading to the prompt clearance of the dying cells. However, the identity and in vivo relevance of such find-me signals are not well understood. Here, through several lines of evidence, we identify extracellular nucleotides as a critical apoptotic cell find-me signal. We demonstrate the caspase-dependent release of ATP and UTP (in equimolar quantities) during the early stages of apoptosis by primary thymocytes and cell lines. Purified nucleotides at these concentrations were sufficient to induce monocyte recruitment comparable to that of apoptotic cell supernatants. Enzymatic removal of ATP and UTP (by apyrase or the expression of ectopic CD39) abrogated the ability of apoptotic cell supernatants to recruit monocytes in vitro and in vivo. We then identified the ATP/UTP receptor P2Y(2) as a critical sensor of nucleotides released by apoptotic cells using RNA interference-mediated depletion studies in monocytes, and macrophages from P2Y(2)-null mice. The relevance of nucleotides in apoptotic cell clearance in vivo was revealed by two approaches. First, in a murine air-pouch model, apoptotic cell supernatants induced a threefold greater recruitment of monocytes and macrophages than supernatants from healthy cells did; this recruitment was abolished by depletion of nucleotides and was significantly decreased in P2Y(2)(-/-) (also known as P2ry2(-/-)) mice. Second, clearance of apoptotic thymocytes was significantly impaired by either depletion of nucleotides or interference with P2Y receptor function (by pharmacological inhibition or in P2Y(2)(-/-) mice). These results identify nucleotides as a critical find-me cue released by apoptotic cells to promote P2Y(2)-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find-me signal and efficient corpse clearance in vivo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851546/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851546/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elliott, Michael R -- Chekeni, Faraaz B -- Trampont, Paul C -- Lazarowski, Eduardo R -- Kadl, Alexandra -- Walk, Scott F -- Park, Daeho -- Woodson, Robin I -- Ostankovich, Marina -- Sharma, Poonam -- Lysiak, Jeffrey J -- Harden, T Kendall -- Leitinger, Norbert -- Ravichandran, Kodi S -- R01 GM064709/GM/NIGMS NIH HHS/ -- R01 GM064709-07/GM/NIGMS NIH HHS/ -- R01 GM069998/GM/NIGMS NIH HHS/ -- R01 GM069998-04/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Sep 10;461(7261):282-6. doi: 10.1038/nature08296.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741708" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*metabolism/pharmacology/secretion ; Animals ; Apoptosis/*physiology ; Cell Line ; Cells, Cultured ; Chemotactic Factors/metabolism/pharmacology/secretion ; Chemotaxis/drug effects ; Culture Media, Conditioned/chemistry/metabolism/pharmacology ; Humans ; Jurkat Cells ; Macrophage Activation/drug effects ; Macrophages/cytology/drug effects/metabolism ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology/drug effects/metabolism ; Phagocytes/*cytology/drug effects/metabolism ; Phagocytosis/drug effects/*physiology ; Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2/deficiency/genetics/metabolism ; Receptors, Purinergic P2Y2 ; *Signal Transduction/drug effects ; Thymus Gland/*cytology ; Uridine Triphosphate/*metabolism/pharmacology/secretion
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-17
    Description: Apoptosis and the subsequent clearance of dying cells occurs throughout development and adult life in many tissues. Failure to promptly clear apoptotic cells has been linked to many diseases. ELMO1 is an evolutionarily conserved cytoplasmic engulfment protein that functions downstream of the phosphatidylserine receptor BAI1, and, along with DOCK1 and the GTPase RAC1, promotes internalization of the dying cells. Here we report the generation of ELMO1-deficient mice, which we found to be unexpectedly viable and grossly normal. However, they had a striking testicular pathology, with disrupted seminiferous epithelium, multinucleated giant cells, uncleared apoptotic germ cells and decreased sperm output. Subsequent in vitro and in vivo analyses revealed a crucial role for ELMO1 in the phagocytic clearance of apoptotic germ cells by Sertoli cells lining the seminiferous epithelium. The engulfment receptor BAI1 and RAC1 (upstream and downstream of ELMO1, respectively) were also important for Sertoli-cell-mediated engulfment. Collectively, these findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773546/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773546/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elliott, Michael R -- Zheng, Shuqiu -- Park, Daeho -- Woodson, Robin I -- Reardon, Michael A -- Juncadella, Ignacio J -- Kinchen, Jason M -- Zhang, Jun -- Lysiak, Jeffrey J -- Ravichandran, Kodi S -- R01 GM064709/GM/NIGMS NIH HHS/ -- R01 HD057242/HD/NICHD NIH HHS/ -- England -- Nature. 2010 Sep 16;467(7313):333-7. doi: 10.1038/nature09356.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844538" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/deficiency/genetics/*metabolism ; Angiogenic Proteins/metabolism ; Animals ; *Apoptosis ; Cell Line ; Homeostasis ; Male ; Mice ; Mice, Inbred C57BL ; Neuropeptides/metabolism ; Phagocytosis/*physiology ; Phosphatidylserines/metabolism ; Seminiferous Epithelium/cytology/pathology ; Sertoli Cells/*cytology/*metabolism/pathology ; Signal Transduction ; Spermatozoa/*cytology/pathology ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-15
    Description: Apoptotic cells release 'find-me' signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells. Pharmacological inhibition and siRNA-mediated knockdown of PANX1 led to decreased nucleotide release and monocyte recruitment by apoptotic cells. Conversely, PANX1 overexpression enhanced nucleotide release from apoptotic cells and phagocyte recruitment. Patch-clamp recordings showed that PANX1 was basally inactive, and that induction of PANX1 currents occurred only during apoptosis. Mechanistically, PANX1 itself was a target of effector caspases (caspases 3 and 7), and a specific caspase-cleavage site within PANX1 was essential for PANX1 function during apoptosis. Expression of truncated PANX1 (at the putative caspase cleavage site) resulted in a constitutively open channel. PANX1 was also important for the 'selective' plasma membrane permeability of early apoptotic cells to specific dyes. Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006164/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006164/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chekeni, Faraaz B -- Elliott, Michael R -- Sandilos, Joanna K -- Walk, Scott F -- Kinchen, Jason M -- Lazarowski, Eduardo R -- Armstrong, Allison J -- Penuela, Silvia -- Laird, Dale W -- Salvesen, Guy S -- Isakson, Brant E -- Bayliss, Douglas A -- Ravichandran, Kodi S -- F30 HL096400-03/HL/NHLBI NIH HHS/ -- R01 NS033583/NS/NINDS NIH HHS/ -- T32 AI007496/AI/NIAID NIH HHS/ -- England -- Nature. 2010 Oct 14;467(7317):863-7. doi: 10.1038/nature09413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944749" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism/secretion ; *Apoptosis/drug effects ; Carbenoxolone/pharmacology ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Membrane Permeability/*physiology ; Chemotaxis/drug effects ; Connexins/antagonists & inhibitors/deficiency/genetics/*metabolism ; Electric Conductivity ; Humans ; Jurkat Cells ; Nerve Tissue Proteins/antagonists & inhibitors/deficiency/genetics/*metabolism ; Patch-Clamp Techniques ; Phagocytes/cytology/physiology ; *Phagocytosis/drug effects ; Uridine Triphosphate/metabolism/secretion
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Network analysis of oncogenic Ras activation in cancer (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-10-20
    Description: To investigate the unregulated Ras activation associated with cancer, we developed and validated a mathematical model of Ras signaling. The model-based predictions and associated experiments help explain why only one of two classes of activating Ras point mutations with in vitro transformation potential is commonly found in cancers. Model-based analysis of these mutants uncovered a systems-level process that contributes to total Ras activation in cells. This predicted behavior was supported by experimental observations. We also used the model to identify a strategy in which a drug could cause stronger inhibition on the cancerous Ras network than on the wild-type network. This system-level analysis of the oncogenic Ras network provides new insights and potential therapeutic strategies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stites, Edward C -- Trampont, Paul C -- Ma, Zhong -- Ravichandran, Kodi S -- New York, N.Y. -- Science. 2007 Oct 19;318(5849):463-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Beirne B. Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17947584" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/metabolism/pharmacology ; Cell Line ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; *Computer Simulation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GTP Phosphohydrolases/metabolism ; GTPase-Activating Proteins/antagonists & inhibitors/metabolism ; Genes, ras ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Mathematics ; *Metabolic Networks and Pathways ; *Models, Biological ; Neoplasms/*metabolism ; Phosphorylation ; Point Mutation ; *Signal Transduction ; ras Proteins/antagonists & inhibitors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein (2011)
    Nature Publishing Group (NPG)
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    Publication Date: 2011-08-23
    Description: Rapid and efficient removal of apoptotic cells by phagocytes is important during development, tissue homeostasis and in immune responses. Efficient clearance depends on the capacity of a single phagocyte to ingest multiple apoptotic cells successively, and to process the corpse-derived cellular material. However, the factors that influence continued clearance by phagocytes are not known. Here we show that the mitochondrial membrane potential of the phagocyte critically controls engulfment capacity, with lower potential enhancing engulfment and vice versa. The mitochondrial membrane protein Ucp2, which acts to lower the mitochondrial membrane potential, was upregulated in phagocytes engulfing apoptotic cells. Loss of Ucp2 reduced phagocytic capacity, whereas Ucp2 overexpression enhanced engulfment. Mutational and pharmacological studies indicated a direct role for Ucp2-mediated mitochondrial function in phagocytosis. Macrophages from Ucp2-deficient mice were impaired in phagocytosis in vitro, and Ucp2-deficient mice showed profound in vivo defects in clearing dying cells in the thymus and testes. Collectively, these data indicate that mitochondrial membrane potential and Ucp2 are key molecular determinants of apoptotic cell clearance. As Ucp2 is linked to metabolic diseases and atherosclerosis, this newly discovered role for Ucp2 in apoptotic cell clearance has implications for the complex aetiology and pathogenesis of these diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513690/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513690/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Park, Daeho -- Han, Claudia Z -- Elliott, Michael R -- Kinchen, Jason M -- Trampont, Paul C -- Das, Soumita -- Collins, Sheila -- Lysiak, Jeffrey J -- Hoehn, Kyle L -- Ravichandran, Kodi S -- R01 GM064709/GM/NIGMS NIH HHS/ -- R01 HD057242/HD/NICHD NIH HHS/ -- T32 GM008136/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Aug 21;477(7363):220-4. doi: 10.1038/nature10340.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21857682" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Cell Line ; Cell Size/drug effects ; Cells, Cultured ; Ion Channels/deficiency/genetics/*metabolism ; Membrane Potential, Mitochondrial/drug effects/physiology ; Mice ; Mitochondrial Proteins/deficiency/genetics/*metabolism ; Phagocytes/*cytology/drug effects/*metabolism ; Phagocytosis/drug effects/*physiology ; Thymus Gland/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
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    Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-04-26
    Description: Skeletal muscle arises from the fusion of precursor myoblasts into multinucleated myofibres. Although conserved transcription factors and signalling proteins involved in myogenesis have been identified, upstream regulators are less well understood. Here we report an unexpected discovery that the membrane protein BAI1, previously linked to recognition of apoptotic cells by phagocytes, promotes myoblast fusion. Endogenous BAI1 expression increased during myoblast fusion, and BAI1 overexpression enhanced myoblast fusion by means of signalling through ELMO/Dock180/Rac1 proteins. During myoblast fusion, a fraction of myoblasts within the population underwent apoptosis and exposed phosphatidylserine, an established ligand for BAI1 (ref. 3). Blocking apoptosis potently impaired myoblast fusion, and adding back apoptotic myoblasts restored fusion. Furthermore, primary human myoblasts could be induced to form myotubes by adding apoptotic myoblasts, even under normal growth conditions. Mechanistically, apoptotic cells did not directly fuse with the healthy myoblasts, rather the apoptotic cells induced a contact-dependent signalling with neighbours to promote fusion among the healthy myoblasts. In vivo, myofibres from Bai1(-/-) mice are smaller than those from wild-type littermates. Muscle regeneration after injury was also impaired in Bai1(-/-)mice, highlighting a role for BAI1 in mammalian myogenesis. Collectively, these data identify apoptotic cells as a new type of cue that induces signalling via the phosphatidylserine receptor BAI1 to promote fusion of healthy myoblasts, with important implications for muscle development and repair.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773542/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773542/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochreiter-Hufford, Amelia E -- Lee, Chang Sup -- Kinchen, Jason M -- Sokolowski, Jennifer D -- Arandjelovic, Sanja -- Call, Jarrod A -- Klibanov, Alexander L -- Yan, Zhen -- Mandell, James W -- Ravichandran, Kodi S -- P30 CA044579/CA/NCI NIH HHS/ -- R01 GM064709/GM/NIGMS NIH HHS/ -- T32 AI007496/AI/NIAID NIH HHS/ -- T32 AR007612/AR/NIAMS NIH HHS/ -- England -- Nature. 2013 May 9;497(7448):263-7. doi: 10.1038/nature12135. Epub 2013 Apr 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23615608" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenic Proteins/deficiency/genetics/*metabolism ; Animals ; Apoptosis/drug effects/*physiology ; Cell Communication ; Cell Differentiation ; *Cell Fusion ; Cell Line ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Development ; Muscle Fibers, Skeletal/cytology/metabolism/pathology ; Muscle, Skeletal/*cytology/metabolism ; Myoblasts/*cytology/metabolism ; Phosphatidylserines/metabolism ; Receptors, Cell Surface/deficiency/genetics/*metabolism ; *Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-12-14
    Description: Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficiently engulf apoptotic epithelial cells and secrete anti-inflammatory cytokines, dependent upon intracellular signalling by the small GTPase Rac1. Inducible deletion of Rac1 expression specifically in airway epithelial cells in a mouse model resulted in defective engulfment by epithelial cells and aberrant anti-inflammatory cytokine production. Intranasal priming and challenge of these mice with house dust mite extract or ovalbumin as allergens led to exacerbated inflammation, augmented Th2 cytokines and airway hyper-responsiveness, with decreased interleukin (IL)-10 in bronchial lavages. Rac1-deficient epithelial cells produced much higher IL-33 upon allergen or apoptotic cell encounter, with increased numbers of nuocyte-like cells. Administration of exogenous IL-10 'rescued' the airway inflammation phenotype in Rac1-deficient mice, with decreased IL-33. Collectively, these genetic and functional studies suggest a new role for Rac1-dependent engulfment by airway epithelial cells and in establishing the anti-inflammatory environment, and that defects in cell clearance in the airways could contribute to inflammatory responses towards common allergens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662023/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662023/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Juncadella, Ignacio J -- Kadl, Alexandra -- Sharma, Ashish K -- Shim, Yun M -- Hochreiter-Hufford, Amelia -- Borish, Larry -- Ravichandran, Kodi S -- R01 AI057438/AI/NIAID NIH HHS/ -- T32 AI007496/AI/NIAID NIH HHS/ -- U01 AI100799/AI/NIAID NIH HHS/ -- England -- Nature. 2013 Jan 24;493(7433):547-51. doi: 10.1038/nature11714. Epub 2012 Dec 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Carter Immunology Center, University of Virginia, Charlottesville, Virginia 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23235830" target="_blank"〉PubMed〈/a〉
    Keywords: Allergens/immunology ; Animals ; *Apoptosis ; Bronchi/*cytology/immunology/pathology ; Bronchoalveolar Lavage Fluid/chemistry/immunology ; Dust/immunology ; Epithelial Cells/immunology/*physiology ; Immunity, Innate/immunology ; Inflammation/immunology/*pathology ; Interleukin-10/biosynthesis/immunology ; Interleukin-33 ; Interleukins/biosynthesis/immunology ; Lung/immunology/*pathology ; Mice ; Ovalbumin/immunology ; *Phagocytosis ; Pyroglyphidae/immunology ; Respiratory Hypersensitivity/immunology/*pathology ; Th2 Cells/immunology/secretion ; Up-Regulation ; rac1 GTP-Binding Protein/deficiency/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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