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  • 101
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408607/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408607/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halloran, M Elizabeth -- Vespignani, Alessandro -- Bharti, Nita -- Feldstein, Leora R -- Alexander, K A -- Ferrari, Matthew -- Shaman, Jeffrey -- Drake, John M -- Porco, Travis -- Eisenberg, Joseph N S -- Del Valle, Sara Y -- Lofgren, Eric -- Scarpino, Samuel V -- Eisenberg, Marisa C -- Gao, Daozhou -- Hyman, James M -- Eubank, Stephen -- Longini, Ira M Jr -- R01 GM100467/GM/NIGMS NIH HHS/ -- U01 GM070694/GM/NIGMS NIH HHS/ -- U01 GM087728/GM/NIGMS NIH HHS/ -- U01 GM097661/GM/NIGMS NIH HHS/ -- U01 GM110712/GM/NIGMS NIH HHS/ -- U01 GM110744/GM/NIGMS NIH HHS/ -- U01 GM110748/GM/NIGMS NIH HHS/ -- U54 GM111274/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):433. doi: 10.1126/science.346.6208.433-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. betz@u.washington.edu. ; Department of Physics, Northeastern University, Boston, MA 02115, USA. ; Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. ; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA. Department of Epidemiology, University of Washington, Seattle, WA 98195, USA. ; Department of Fish and Wildlife Conservation, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. ; Odum School of Ecology, University of Georgia, Athens, GA 30602, USA. ; Francis I. Proctor Foundation, University of California, San Francisco, CA 94143, USA. ; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. ; Los Alamos National Laboratory, Los Alamos, NM 87545, USA. ; Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Santa Fe Institute, Santa Fe, NM 87501, USA. ; Department of Mathematics, Tulane University, New Orleans, LA 70118, USA. ; Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Department of Population Health Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Department of Biostatistics, University of Florida, Gainesville, FL 32611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342792" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa, Western/epidemiology ; Ebolavirus/*genetics/isolation & purification ; Epidemiological Monitoring ; Genomics ; Hemorrhagic Fever, Ebola/*epidemiology ; *Human Migration ; Humans ; Travel
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 102
    Publikationsdatum: 2014-05-24
    Beschreibung: Decisions take time if information gradually accumulates to a response threshold, but the neural mechanisms of integration and thresholding are unknown. We characterized a decision process in Drosophila that bears the behavioral signature of evidence accumulation. As stimulus contrast in trained odor discriminations decreased, reaction times increased and perceptual accuracy declined, in quantitative agreement with a drift-diffusion model. FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks. RNA interference with FoxP expression in alphabeta core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. A mushroom body subdomain whose development or function require the transcription factor FoxP thus supports the progression of a decision toward commitment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206523/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206523/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DasGupta, Shamik -- Ferreira, Clara Howcroft -- Miesenbock, Gero -- 090309/Wellcome Trust/United Kingdom -- G0700888/Medical Research Council/United Kingdom -- G0701225/Medical Research Council/United Kingdom -- R01 DA030601/DA/NIDA NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2014 May 23;344(6186):901-4. doi: 10.1126/science.1252114.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, OX1 3SR, UK. ; Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, OX1 3SR, UK. gero.miesenboeck@cncb.ox.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855268" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Behavior, Animal ; Cell Line ; *Decision Making ; Drosophila Proteins/genetics/*physiology ; Drosophila melanogaster/genetics/*physiology ; Forkhead Transcription Factors/genetics/*physiology ; Mushroom Bodies/growth & development/metabolism ; Mutation ; Neurons/physiology ; Odors ; *Psychomotor Performance ; RNA Interference ; Reaction Time/genetics/*physiology ; Smell
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 103
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blair, H T -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):846-7. doi: 10.1126/science.1251252.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Psychology Department and Brain Research Institute, University of California, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Association ; CA1 Region, Hippocampal/*physiology ; Entorhinal Cortex/*cytology/*physiology ; Female ; Male ; *Memory, Episodic ; *Nerve Net ; Neurons/*physiology ; Pyramidal Cells/*physiology/*ultrastructure ; *Theta Rhythm
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 104
    Publikationsdatum: 2014-09-13
    Beschreibung: This Perspective focuses on the future of the Pandemic Influenza Preparedness (PIP) Framework, which was initially established to promote the fair sharing of public health-related pandemic influenza samples between countries. We examine the changes that need to be made to address the growing likelihood that genetic sequence data might be shared instead of physical virus samples, as well as the need to expand the PIP framework's scope and to improve its fairness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gostin, Lawrence O -- Phelan, Alexandra -- Stoto, Michael A -- Kraemer, John D -- Reddy, K Srinath -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1295-6. doi: 10.1126/science.1257622.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC 20001, USA. ; Department of Health Systems Administration, Georgetown University, Washington, DC 20057, USA. ; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC 20001, USA. Department of Health Systems Administration, Georgetown University, Washington, DC 20057, USA. ; President, Public Health Foundation of India, New Delhi 110070, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Disaster Planning ; *Global Health ; Health Services Accessibility ; Humans ; Influenza A Virus, H1N1 Subtype/*genetics ; Influenza A Virus, H5N1 Subtype/*genetics ; *Influenza Vaccines ; Influenza in Birds/epidemiology/prevention & control ; Influenza, Human/epidemiology/*prevention & control/virology ; Intellectual Property ; Orthomyxoviridae Infections/prevention & control/virology ; Pandemics/*prevention & control/veterinary ; Poultry ; Sequence Analysis, DNA ; Swine
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 105
    Publikationsdatum: 2014-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perie, Leila -- Riboli-Sasco, Livio -- Ribrault, Claire -- Zlotek-Zlotkiewicz, Ewa -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):740. doi: 10.1126/science.345.6198.740-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Netherlands Cancer Institute, Amsterdam, 1066CX, Netherlands. Utrecht University, 3584 CH Utrecht, Netherlands. l.perie@nki.nl. ; Atelier des Jours a Venir, 75006 Paris, France. ; Institut Curie/CNRS UMR 144, 75005 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124421" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Humans ; Middle East ; *Research ; *Research Personnel ; Science/*education
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 106
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goudsmit, Jaap -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):881. doi: 10.1126/science.1259453.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. jaap@jaapgoudsmit.nl.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/blood/*history/immunology ; HIV/immunology ; HIV Antibodies/blood/*history ; History, 20th Century ; History, 21st Century ; Humans ; Netherlands
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 107
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McClung, C Robertson -- New York, N.Y. -- Science. 2014 May 16;344(6185):699-700. doi: 10.1126/science.1254135.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Dartmouth College, Hanover, NH, USA. c.robertson.mcclung@dartmouth.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833378" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Breeding/*methods ; *Crops, Agricultural ; *Food Supply ; Humans ; *Hunger ; Oryza ; Plants, Genetically Modified ; *Population Growth
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 108
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Nov 21;346(6212):908-11. doi: 10.1126/science.346.6212.908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25414285" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Viral/immunology ; Antiviral Agents/therapeutic use ; Cytosine/analogs & derivatives/therapeutic use ; Ebolavirus/drug effects/immunology ; Hemorrhagic Fever, Ebola/*drug therapy/epidemiology/immunology ; Humans ; Organophosphonates/therapeutic use ; Randomized Controlled Trials as Topic ; Serum/immunology ; Therapies, Investigational/ethics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 109
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, William J -- Kull, Christian A -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):358. doi: 10.1126/science.344.6182.358-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Systems Integration and Sustainability, Michigan State University, East Lansing, MI 48823, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763569" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Endangered Species ; *Extinction, Biological ; *Lemur ; Male
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 110
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):289-90. doi: 10.1126/science.346.6207.289.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324364" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Clinical Trials, Phase III as Topic/ethics ; Double-Blind Method ; Ebola Vaccines/*administration & dosage/adverse effects ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/*prevention & control ; Humans ; Liberia/epidemiology ; Randomized Controlled Trials as Topic/ethics ; Sierra Leone/epidemiology ; World Health Organization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 111
    Publikationsdatum: 2014-04-12
    Beschreibung: Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, inhibition is mediated largely by GABAergic (gamma-aminobutyric acid-secreting) interneurons, a cell type that originates in the embryonic ventral telencephalon and populates the cortex through long-distance tangential migration. Remarkably, when transplanted from embryos or in vitro culture preparations, immature interneurons disperse and integrate into host brain circuits, both in the cerebral cortex and in other regions of the central nervous system. These features make interneuron transplantation a powerful tool for the study of neurodevelopmental processes such as cell specification, cell death, and cortical plasticity. Moreover, interneuron transplantation provides a novel strategy for modifying neural circuits in rodent models of epilepsy, Parkinson's disease, mood disorders, and chronic pain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056344/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056344/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Southwell, Derek G -- Nicholas, Cory R -- Basbaum, Allan I -- Stryker, Michael P -- Kriegstein, Arnold R -- Rubenstein, John L -- Alvarez-Buylla, Arturo -- HD032116/HD/NICHD NIH HHS/ -- MH049428/MH/NIMH NIH HHS/ -- NS14627/NS/NINDS NIH HHS/ -- NS28478/NS/NINDS NIH HHS/ -- NS78326/NS/NINDS NIH HHS/ -- R01 EY002874/EY/NEI NIH HHS/ -- R01 MH049428/MH/NIMH NIH HHS/ -- R01 NS014627/NS/NINDS NIH HHS/ -- R01 NS028478/NS/NINDS NIH HHS/ -- R01 NS078326/NS/NINDS NIH HHS/ -- R01-EY02874/EY/NEI NIH HHS/ -- R37 HD032116/HD/NICHD NIH HHS/ -- T32 GM008568/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):1240622. doi: 10.1126/science.1240622.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723614" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Count ; Cell Separation ; *Cell- and Tissue-Based Therapy ; Cerebral Cortex/cytology/growth & development/physiology ; *Embryonic Development ; Humans ; Interneurons/*physiology/*transplantation ; Mental Disorders/*therapy ; Mice ; Nervous System Diseases/*therapy
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 112
    Publikationsdatum: 2014-12-17
    Beschreibung: Some HIV-infected individuals develop broadly neutralizing antibodies (bNAbs), whereas most develop antibodies that neutralize only a narrow range of viruses (nNAbs). bNAbs, but not nNAbs, protect animals from experimental infection and are likely a key component of an effective vaccine. nNAbs and bNAbs target the same regions of the viral envelope glycoprotein (Env), but for reasons that remain unclear only nNAbs are elicited by Env immunization. We show that in contrast to germline-reverted (gl) bNAbs, glnNAbs recognized diverse recombinant Envs. Moreover, owing to binding affinity differences, nNAb B cell progenitors had an advantage in becoming activated and internalizing Env compared with bNAb B cell progenitors. We then identified an Env modification strategy that minimized the activation of nNAb B cells targeting epitopes that overlap those of bNAbs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290850/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290850/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Andrew T -- Dreyer, Anita M -- Carbonetti, Sara -- Lippy, Adriana -- Glenn, Jolene -- Scheid, Johannes F -- Mouquet, Hugo -- Stamatatos, Leonidas -- P01 AI094419/AI/NIAID NIH HHS/ -- P01 AI094419-01/AI/NIAID NIH HHS/ -- U19 19AI109632-01/AI/NIAID NIH HHS/ -- U19 AI109632/AI/NIAID NIH HHS/ -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2014 Dec 12;346(6215):1380-3. doi: 10.1126/science.1259206.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Seattle Biomedical Research Institute, Seattle, WA 98109, USA. ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. ; Laboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur and CNRS-URA 1961, 75015 Paris, France. ; Seattle Biomedical Research Institute, Seattle, WA 98109, USA. Department of Global Health, University of Washington, Seattle, WA 98109, USA. lstamata@fhcrc.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25504724" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/immunology ; Antibodies, Neutralizing/*immunology ; Antibody Affinity ; B-Lymphocytes/immunology ; Binding, Competitive ; Epitopes/immunology ; HIV Antibodies/genetics/*immunology ; HIV-1/*immunology ; Humans ; Lymphocyte Activation ; Models, Molecular ; Receptors, Antigen, B-Cell/genetics/immunology ; Recombinant Proteins/immunology ; env Gene Products, Human Immunodeficiency Virus/chemistry/genetics/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 113
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1190-3. doi: 10.1126/science.343.6176.1190.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Affective Symptoms/therapy ; Antipsychotic Agents/adverse effects/therapeutic use ; Cognitive Therapy/*methods ; Delusions/therapy ; Drug Discovery ; Genes ; Hallucinations/therapy ; Humans ; Male ; Middle Aged ; Placebo Effect ; Psychotherapy, Psychodynamic/*methods ; Randomized Controlled Trials as Topic ; Schizophrenia/drug therapy/genetics/*therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 114
    Publikationsdatum: 2014-12-17
    Beschreibung: Sex-specific chromosomes, like the W of most female birds and the Y of male mammals, usually have lost most genes owing to a lack of recombination. We analyze newly available genomes of 17 bird species representing the avian phylogenetic range, and find that more than half of them do not have as fully degenerated W chromosomes as that of chicken. We show that avian sex chromosomes harbor tremendous diversity among species in their composition of pseudoautosomal regions and degree of Z/W differentiation. Punctuated events of shared or lineage-specific recombination suppression have produced a gradient of "evolutionary strata" along the Z chromosome, which initiates from the putative avian sex-determining gene DMRT1 and ends at the pseudoautosomal region. W-linked genes are subject to ongoing functional decay after recombination was suppressed, and the tempo of degeneration slows down in older strata. Overall, we unveil a complex history of avian sex chromosome evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhou, Qi -- Zhang, Jilin -- Bachtrog, Doris -- An, Na -- Huang, Quanfei -- Jarvis, Erich D -- Gilbert, M Thomas P -- Zhang, Guojie -- GM076007/GM/NIGMS NIH HHS/ -- GM093182/GM/NIGMS NIH HHS/ -- R01 GM076007/GM/NIGMS NIH HHS/ -- R01 GM093182/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Dec 12;346(6215):1246338. doi: 10.1126/science.1246338. Epub 2014 Dec 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Biology, University of California, Berkeley, CA94720, USA. zhouqi@berkeley.edu zhanggj@genomics.org.cn. ; China National Genebank, BGI-Shenzhen, Shenzhen, 518083. China. ; Department of Integrative Biology, University of California, Berkeley, CA94720, USA. ; Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA. ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen, Denmark. Trace and Environmental DNA laboratory, Department of Environment and Agriculture, Curtin University, Perth, Western Australia 6102, Australia. ; China National Genebank, BGI-Shenzhen, Shenzhen, 518083. China. Centre for Social Evolution, Department of Biology, Universitetsparken 15, University of Copenhagen, DK-2100 Copenhagen, Denmark. zhouqi@berkeley.edu zhanggj@genomics.org.cn.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25504727" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Proteins/genetics ; *Biological Evolution ; Birds/classification/*genetics ; Chickens/genetics ; Chromosome Inversion ; Chromosome Mapping ; *Evolution, Molecular ; Female ; Male ; Phylogeny ; Recombination, Genetic ; Sex Chromosomes/*genetics ; Species Specificity ; Struthioniformes/genetics ; Synteny ; Transcription Factors/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 115
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanton, Richard E -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):485-6. doi: 10.1126/science.343.6170.485-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, Purdue University, West Lafayette, IN 47907, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24482466" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Capitalism ; Family/*history ; Female ; *Fertility ; Humans ; Plague/*history ; Women/*history ; Work/*history
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 116
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-14
    Beschreibung: Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523269/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523269/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanpain, Cedric -- Fuchs, Elaine -- R01 AR031737/AR/NIAMS NIH HHS/ -- R01 AR050452/AR/NIAMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1242281. doi: 10.1126/science.1242281. Epub 2014 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire (IRIBHM), Universite Libre de Bruxelles, Brussels B-1070, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Universite Libre de Bruxelles (ULB), Brussels B-1070, Belgium. fuchslb@rockefeller.edu cedric.blanpain@ulb.ac.be. ; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. fuchslb@rockefeller.edu cedric.blanpain@ulb.ac.be.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926024" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinogenesis/pathology ; Cell Lineage ; Cell Tracking ; Epithelial Cells/cytology/pathology/*physiology ; Epithelium/physiology ; Humans ; *Regeneration ; Regenerative Medicine/trends ; Stem Cells/cytology/pathology/*physiology ; Wound Healing
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 117
    Publikationsdatum: 2014-03-01
    Beschreibung: One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L. We report 2.8 and 2.1 angstrom crystal structures of human RNase L in complexes with synthetic and natural ligands and a fragment of an RNA substrate. RNase L forms a crossed homodimer stabilized by ankyrin (ANK) and kinase homology (KH) domains, which positions two kinase extension nuclease (KEN) domains for asymmetric RNA recognition. One KEN protomer recognizes an identity nucleotide (U), whereas the other protomer cleaves RNA between nucleotides +1 and +2. The coordinated action of the ANK, KH, and KEN domains thereby provides regulated, sequence-specific cleavage of viral and host RNA targets by RNase L.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731867/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731867/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Han, Yuchen -- Donovan, Jesse -- Rath, Sneha -- Whitney, Gena -- Chitrakar, Alisha -- Korennykh, Alexei -- R01 GM110161/GM/NIGMS NIH HHS/ -- T32 GM007388/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1244-8. doi: 10.1126/science.1249845. Epub 2014 Feb 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Princeton University, 216 Schultz Laboratory, Princeton, NJ 08540, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24578532" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Crystallography, X-Ray ; Endoribonucleases/*chemistry/metabolism ; HeLa Cells ; Hepatitis B virus/genetics ; Humans ; Interferon Type I/pharmacology/*physiology ; Protein Multimerization ; Protein Structure, Tertiary ; *RNA Cleavage ; *RNA Stability ; RNA, Viral/chemistry
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 118
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):716-7. doi: 10.1126/science.343.6172.716.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531945" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Archaeology ; Emigrants and Immigrants/history ; Genome, Human/*genetics ; History, Ancient ; Humans ; Indians, North American/*genetics/history ; Infant ; Male ; Montana ; Sequence Analysis, DNA ; Skull
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 119
    Publikationsdatum: 2014-03-01
    Beschreibung: Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X syndrome, the most common genetic form of mental retardation, a CGG trinucleotide-repeat expansion adjacent to the fragile X mental retardation 1 (FMR1) gene promoter results in its epigenetic silencing. Here, we show that FMR1 silencing is mediated by the FMR1 mRNA. The FMR1 mRNA contains the transcribed CGG-repeat tract as part of the 5' untranslated region, which hybridizes to the complementary CGG-repeat portion of the FMR1 gene to form an RNA.DNA duplex. Disrupting the interaction of the mRNA with the CGG-repeat portion of the FMR1 gene prevents promoter silencing. Thus, our data link trinucleotide-repeat expansion to a form of RNA-directed gene silencing mediated by direct interactions of the trinucleotide-repeat RNA and DNA.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357282/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357282/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colak, Dilek -- Zaninovic, Nikica -- Cohen, Michael S -- Rosenwaks, Zev -- Yang, Wang-Yong -- Gerhardt, Jeannine -- Disney, Matthew D -- Jaffrey, Samie R -- R01 GM079235/GM/NIGMS NIH HHS/ -- R01 MH80420/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2014 Feb 28;343(6174):1002-5. doi: 10.1126/science.1245831.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24578575" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; DNA Methylation ; Embryonic Stem Cells/metabolism ; Fragile X Mental Retardation Protein/*genetics ; Fragile X Syndrome/*genetics ; *Gene Silencing ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neurons/metabolism ; Nuclear Proteins/genetics ; Promoter Regions, Genetic/genetics ; RNA, Messenger/*genetics ; RNA, Small Interfering/genetics ; Trinucleotide Repeats/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 120
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Susiarjo, Martha -- Bartolomei, Marisa S -- P30 ES013508/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):733-4. doi: 10.1126/science.1258654.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. bartolom@mail.med.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124413" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *DNA Methylation ; Female ; Fetal Nutrition Disorders/*metabolism ; Male ; Pregnancy ; *Prenatal Exposure Delayed Effects ; Spermatozoa/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 121
    Publikationsdatum: 2014-10-25
    Beschreibung: Study of human adaptation to extreme environments is important for understanding our cultural and genetic capacity for survival. The Pucuncho Basin in the southern Peruvian Andes contains the highest-altitude Pleistocene archaeological sites yet identified in the world, about 900 meters above confidently dated contemporary sites. The Pucuncho workshop site [4355 meters above sea level (masl)] includes two fishtail projectile points, which date to about 12.8 to 11.5 thousand years ago (ka). Cuncaicha rock shelter (4480 masl) has a robust, well-preserved, and well-dated occupation sequence spanning the past 12.4 thousand years (ky), with 21 dates older than 11.5 ka. Our results demonstrate that despite cold temperatures and low-oxygen conditions, hunter-gatherers colonized extreme high-altitude Andean environments in the Terminal Pleistocene, within about 2 ky of the initial entry of humans to South America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rademaker, Kurt -- Hodgins, Gregory -- Moore, Katherine -- Zarrillo, Sonia -- Miller, Christopher -- Bromley, Gordon R M -- Leach, Peter -- Reid, David A -- Alvarez, Willy Yepez -- Sandweiss, Daniel H -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):466-9. doi: 10.1126/science.1258260.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, South Stevens Hall, University of Maine, Orono, ME 04469-5773, USA. Department of Early Prehistory and Quaternary Ecology, Schloss Hohentubingen, Burgsteige 11, 72070 Tubingen, Germany. Climate Change Institute, Bryand Global Sciences Center, University of Maine, Orono, ME 04469, USA. kurt.rademaker@umit.maine.edu. ; Accelerator Mass Spectrometry Laboratory, Department of Physics and School of Anthropology, University of Arizona, Tucson, AZ 85721, USA. ; University of Pennsylvania Museum, 3260 South Street, Philadelphia, PA 19104, USA. ; Department of Anthropology and Archaeology, Earth Sciences Building, Room 806, 844 Campus Place Northwest, Calgary, British Columbia, Canada. ; Institute for Archaeological Sciences, University of Tubingen, Rumelinstrasse 23, 72070 Tubingen, Germany. Senckenberg Centre for Human Evolution and Paleoenvironment, University of Tubingen, Rumelinstrasse 23, 72070 Tubingen, Germany. ; Climate Change Institute, Bryand Global Sciences Center, University of Maine, Orono, ME 04469, USA. ; Department of Anthropology, 354 Mansfield Road, University of Connecticut, Storrs, CT 06269-1176, USA. ; Department of Anthropology, University of Illinois at Chicago, Behavioral Sciences Building, 1007 West Harrison Street, Chicago, IL 60607-7139, USA. ; Arequipa, Peru. ; Department of Anthropology, South Stevens Hall, University of Maine, Orono, ME 04469-5773, USA. Climate Change Institute, Bryand Global Sciences Center, University of Maine, Orono, ME 04469, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342802" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acclimatization ; *Altitude ; Archaeology ; Artifacts ; Humans ; Peru
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 122
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, Barry R -- Marcuse, Edgar -- Mnookin, Seth -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):339. doi: 10.1126/science.1254834.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Barry R. Bloom is a professor at the Harvard School of Public Health, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763557" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Disease Outbreaks/*prevention & control ; *Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Parents/*psychology ; *Research ; Research Design ; *Treatment Refusal/psychology ; United States ; *Vaccination/psychology/utilization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 123
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoback, Mary Lou -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):283. doi: 10.1126/science.1261788.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mary Lou Zoback is a consulting professor in the Department of Geophysics, Stanford University, Stanford, CA. marylouz@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324360" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): California ; Disasters/*history ; Earthquakes/*history/mortality ; Haiti ; History, 20th Century ; Humans ; Rescue Work
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 124
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabesandratana, Tania -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):586-7. doi: 10.1126/science.343.6171.586.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503823" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*ethics ; *Conflict of Interest ; Epidemiology/*ethics ; France ; Humans ; *Leadership ; Lung Neoplasms/chemically induced/*epidemiology ; Vehicle Emissions/*toxicity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 125
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-12
    Beschreibung: A vaccine against HIV-1 must prevent infection against genetically diverse virus strains. Two approaches are currently being pursued to elicit antibody-mediated protection: vaccines that induce potent and broadly reactive neutralizing antibodies (bnAbs) or vaccines that induce "conventional antibodies," which are less potent and broadly neutralizing in comparison. Although bnAbs may provide the greatest level of protection, their structural and genetic characteristics make their elicitation through vaccination a major challenge. In contrast, conventional HIV-1 antibodies have been induced by vaccination and correlated with reduced HIV-1 infection in a phase III vaccine trial. Here, I present evidence that both approaches should be pursued with equal vigor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481191/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481191/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zolla-Pazner, Susan -- P01 AI 100151/AI/NIAID NIH HHS/ -- P01 AI100151/AI/NIAID NIH HHS/ -- R01 HL059725/HL/NHLBI NIH HHS/ -- R01 HL59725/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):167-8. doi: 10.1126/science.1256526.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New York Veterans Affairs Harbor Healthcare System, New York, NY 10010, USA. New York University School of Medicine, New York, NY 10016, USA. zollas01@med.nyu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25013066" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/administration & dosage/*isolation & purification ; Antibodies, Neutralizing/*immunology ; Antibody Formation ; Clinical Trials, Phase III as Topic ; Drug Design ; Genetic Variation ; HIV Antibodies/*immunology ; HIV Infections/immunology/*prevention & control ; HIV-1/genetics/*immunology ; Humans ; Vaccination
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 126
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Morree, Antoine -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):279. doi: 10.1126/science.345.6194.279.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford School of Medicine, Stanford University Postdoctoral Association, Stanford, CA 94305, USA. demorree@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035483" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/physiology ; Dinosaurs ; Humans ; *Museums ; Science/*education ; Scyphozoa ; Spheniscidae ; Ursidae ; Wales
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 127
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Govindan, Ramaswamy -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):169-70. doi: 10.1126/science.1259926.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. rgovinda@dom.wustl.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301605" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/*genetics ; Carcinoma, Non-Small-Cell Lung/*diagnosis/*genetics ; *Genetic Heterogeneity ; *Genomic Instability ; Humans ; Lung Neoplasms/*diagnosis/*genetics ; Neoplasm Recurrence, Local/*genetics
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  • 128
    Publikationsdatum: 2014-06-07
    Beschreibung: How sleep helps learning and memory remains unknown. We report in mouse motor cortex that sleep after motor learning promotes the formation of postsynaptic dendritic spines on a subset of branches of individual layer V pyramidal neurons. New spines are formed on different sets of dendritic branches in response to different learning tasks and are protected from being eliminated when multiple tasks are learned. Neurons activated during learning of a motor task are reactivated during subsequent non-rapid eye movement sleep, and disrupting this neuronal reactivation prevents branch-specific spine formation. These findings indicate that sleep has a key role in promoting learning-dependent synapse formation and maintenance on selected dendritic branches, which contribute to memory storage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447313/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447313/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Guang -- Lai, Cora Sau Wan -- Cichon, Joseph -- Ma, Lei -- Li, Wei -- Gan, Wen-Biao -- P01 NS074972/NS/NINDS NIH HHS/ -- R01 NS047325/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1173-8. doi: 10.1126/science.1249098.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA. ; Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. ; Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. ; Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. ; Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. gan@saturn.med.nyu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24904169" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dendritic Spines/*physiology ; Female ; Learning/*physiology ; Male ; Mice ; Mice, Mutant Strains ; Motor Cortex/*physiology ; Sleep, REM/*physiology
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  • 129
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):20-1. doi: 10.1126/science.343.6166.20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Husbandry/*history ; Animals ; *Archaeology ; Cattle ; Great Britain ; History, Ancient ; Humans ; Islands ; Sculpture/*history ; Swine
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 130
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Hong -- Thompson, Julian R -- Flower, Roger J -- New York, N.Y. -- Science. 2014 Nov 7;346(6210):710-1. doi: 10.1126/science.346.6210.710-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CEES, Department of Biosciences, University of Oslo, Blindern, 0316 Oslo, Norway. Wetland Research Unit/Environmental Change Research Centre, UCL Department of Geography, University College London, London, WC1E 6BT, UK. hongyanghy@gmail.com. ; Wetland Research Unit/Environmental Change Research Centre, UCL Department of Geography, University College London, London, WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25378613" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Disasters/*history ; Earthquakes/*history ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 131
    Publikationsdatum: 2014-10-18
    Beschreibung: Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In this work, we study the function of these late-forming cells and the myelin they produce. Learning a new motor skill (such as juggling) alters the structure of the brain's white matter, which contains many OLs, suggesting that late-born OLs might contribute to motor learning. Consistent with this idea, we show that production of newly formed OLs is briefly accelerated in mice that learn a new skill (running on a "complex wheel" with irregularly spaced rungs). By genetically manipulating the transcription factor myelin regulatory factor in OL precursors, we blocked production of new OLs during adulthood without affecting preexisting OLs or myelin. This prevented the mice from mastering the complex wheel. Thus, generation of new OLs and myelin is important for learning motor skills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKenzie, Ian A -- Ohayon, David -- Li, Huiliang -- de Faria, Joana Paes -- Emery, Ben -- Tohyama, Koujiro -- Richardson, William D -- 100269/Wellcome Trust/United Kingdom -- G0800575/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):318-22. doi: 10.1126/science.1254960.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK. ; Department of Anatomy and Neuroscience and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia. ; The Center for Electron Microscopy and Bio-Imaging Research, Iwate Medical University, 19-1 Uchimuru, Morioka, Iwate 020-8505, Japan. ; The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK. w.richardson@ucl.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324381" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*cytology/metabolism ; *Cell Proliferation ; Gene Deletion ; Humans ; *Learning ; Male ; Mental Recall ; Mice ; Mice, Transgenic ; Motor Skills/*physiology ; Myelin Sheath/genetics/*metabolism ; Oligodendroglia/cytology/metabolism/*physiology ; Synaptic Transmission ; Transcription Factors/genetics/metabolism
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  • 132
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):18-23. doi: 10.1126/science.343.6166.18.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385617" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/history ; Animals ; *Archaeology ; History, Ancient ; Humans ; Islands ; Scotland ; Sculpture/*history
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 133
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis S -- Wilder, Elizabeth L -- Zerhouni, Elias -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):274-6. doi: 10.1126/science.1255860. Epub 2014 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. francis.collins@nih.gov. ; National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035478" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; *Financial Management ; Humans ; National Institutes of Health (U.S.)/*economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 134
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spiegelhalter, D J -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):264-5. doi: 10.1126/science.1251122. Epub 2014 Jul 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, CB3 0WB, UK. david@statslab.cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035471" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Forecasting ; Humans ; *Knowledge Bases ; *Uncertainty
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 135
    Publikationsdatum: 2014-08-30
    Beschreibung: Cells use actomyosin contractility to move through three-dimensional (3D) extracellular matrices. Contractility affects the type of protrusions cells use to migrate in 3D, but the mechanisms are unclear. In this work, we found that contractility generated high-pressure lobopodial protrusions in human cells migrating in a 3D matrix. In these cells, the nucleus physically divided the cytoplasm into forward and rear compartments. Actomyosin contractility with the nucleoskeleton-intermediate filament linker protein nesprin-3 pulled the nucleus forward and pressurized the front of the cell. Reducing expression of nesprin-3 decreased and equalized the intracellular pressure. Thus, the nucleus can act as a piston that physically compartmentalizes the cytoplasm and increases the hydrostatic pressure between the nucleus and the leading edge of the cell to drive lamellipodia-independent 3D cell migration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petrie, Ryan J -- Koo, Hyun -- Yamada, Kenneth M -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1062-5. doi: 10.1126/science.1256965.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA. petrier@mail.nih.gov kyamada@mail.nih.gov. ; Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA. Center for Oral Biology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104-6030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170155" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actomyosin/physiology ; Cell Movement/*physiology ; Cell Nucleus/*physiology ; Cells, Cultured ; Cytoplasm/physiology ; Extracellular Matrix/*physiology/ultrastructure ; Fibroblasts/*physiology ; Humans ; Hydrostatic Pressure ; Microfilament Proteins ; Pseudopodia/*physiology ; Vimentin/metabolism
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    Standort Signatur Erwartet Verfügbarkeit
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  • 136
    Publikationsdatum: 2014-05-17
    Beschreibung: Environmental exposures affect gamete function and fertility, but the mechanisms are poorly understood. Here, we show that pheromones sensed by ciliated neurons in the Caenorhabditis elegans nose alter the lipid microenvironment within the oviduct, thereby affecting sperm motility. In favorable environments, pheromone-responsive sensory neurons secrete a transforming growth factor-beta ligand called DAF-7, which acts as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent prostaglandin synthesis in the ovary. Oocytes secrete F-class prostaglandins that guide sperm toward them. These prostaglandins are also synthesized in Cox knockout mice, raising the possibility that similar mechanisms exist in other animals. Our data indicate that environmental cues perceived by the female nervous system affect sperm function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094289/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094289/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKnight, Katherine -- Hoang, Hieu D -- Prasain, Jeevan K -- Brown, Naoko -- Vibbert, Jack -- Hollister, Kyle A -- Moore, Ray -- Ragains, Justin R -- Reese, Jeff -- Miller, Michael A -- GM085105/GM/NIGMS NIH HHS/ -- HL096967/HL/NHLBI NIH HHS/ -- HL109199/HL/NHLBI NIH HHS/ -- HL110950/HL/NHLBI NIH HHS/ -- HL114439/HL/NHLBI NIH HHS/ -- P30 AR050948/AR/NIAMS NIH HHS/ -- P30 DK079337/DK/NIDDK NIH HHS/ -- P40 OD010440/OD/NIH HHS/ -- R01 GM085105/GM/NIGMS NIH HHS/ -- R01 HL096967/HL/NHLBI NIH HHS/ -- R01 HL109199/HL/NHLBI NIH HHS/ -- S10 RR19261/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2014 May 16;344(6185):754-7. doi: 10.1126/science.1250598.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA. ; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. mamiller@uab.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833393" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Environmental Exposure ; Female ; *Fertilization ; Male ; Neurons, Afferent/*physiology ; Neurosecretory Systems/physiology ; Oocytes/metabolism/physiology ; Ovum/metabolism/physiology ; Perception ; Pheromones/*physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins/biosynthesis ; *Sperm Motility ; Spermatozoa/*physiology ; Transforming Growth Factor beta/genetics/*metabolism
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  • 137
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1076-9. doi: 10.1126/science.344.6188.1076.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24904136" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Employment ; Faculty/*statistics & numerical data ; Humans ; Mathematics/*education ; Minority Groups/*education ; *Racism ; Universities/*manpower
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 138
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swaminathan, M S -- New York, N.Y. -- Science. 2014 Aug 1;345(6196):491. doi: 10.1126/science.1258820.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉M. S. Swaminathan is the Founder Chairman of the M S Swaminathan Research Foundation, Chennai, India. swami@mssrf.res.in.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25082671" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/*trends ; Asia, Southeastern ; Crops, Agricultural ; Family ; Food Supply/*methods ; Humans ; *Hunger ; India ; United Nations
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 139
    Publikationsdatum: 2014-12-06
    Beschreibung: Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280847/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280847/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sreeramkumar, Vinatha -- Adrover, Jose M -- Ballesteros, Ivan -- Cuartero, Maria Isabel -- Rossaint, Jan -- Bilbao, Izaskun -- Nacher, Maria -- Pitaval, Christophe -- Radovanovic, Irena -- Fukui, Yoshinori -- McEver, Rodger P -- Filippi, Marie-Dominique -- Lizasoain, Ignacio -- Ruiz-Cabello, Jesus -- Zarbock, Alexander -- Moro, Maria A -- Hidalgo, Andres -- HL03463/HL/NHLBI NIH HHS/ -- HL085607/HL/NHLBI NIH HHS/ -- HL090676/HL/NHLBI NIH HHS/ -- P01 HL085607/HL/NHLBI NIH HHS/ -- R01 HL034363/HL/NHLBI NIH HHS/ -- R01 HL090676/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1234-8. doi: 10.1126/science.1256478. Epub 2014 Dec 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. ; Unidad de Investigacion Neurovascular, Department of Pharmacology, Faculty of Medicine, Universidad Complutense and Instituto de Investigacion Hospital 12 de Octubre (i+12), Madrid, Spain. ; Department of Anesthesiology and Critical Care Medicine, University of Munster and Max Planck Institute Munster, Munster, Germany. ; Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Ciber de Enfermedades Respiratorias (CIBERES), Madrid, Spain. ; Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Faculty of Science, Medicine and Health, University of Wollongong, New South Wales, Australia. ; Division of Immunogenetics, Department of Immunobiology and Neuroscience, Kyushu University, Japan. ; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. ; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ; Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany. ahidalgo@cnic.es.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477463" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood Circulation ; Blood Platelets/*immunology ; Cell Movement ; Cell Polarity ; Endothelium, Vascular/immunology ; Inflammation/blood/*immunology ; Male ; Membrane Glycoproteins ; Mice ; Mice, Inbred C57BL ; Neutrophils/*immunology ; *Platelet Activation ; Signal Transduction ; Thrombosis/*immunology ; Venules/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 140
    Publikationsdatum: 2014-10-25
    Beschreibung: During cell entry, capsids of incoming influenza A viruses (IAVs) must be uncoated before viral ribonucleoproteins (vRNPs) can enter the nucleus for replication. After hemagglutinin-mediated membrane fusion in late endocytic vacuoles, the vRNPs and the matrix proteins dissociate from each other and disperse within the cytosol. Here, we found that for capsid disassembly, IAV takes advantage of the host cell's aggresome formation and disassembly machinery. The capsids mimicked misfolded protein aggregates by carrying unanchored ubiquitin chains that activated a histone deacetylase 6 (HDAC6)-dependent pathway. The ubiquitin-binding domain was essential for recruitment of HDAC6 to viral fusion sites and for efficient uncoating and infection. That other components of the aggresome processing machinery, including dynein, dynactin, and myosin II, were also required suggested that physical forces generated by microtubule- and actin-associated motors are essential for IAV entry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Banerjee, Indranil -- Miyake, Yasuyuki -- Nobs, Samuel Philip -- Schneider, Christoph -- Horvath, Peter -- Kopf, Manfred -- Matthias, Patrick -- Helenius, Ari -- Yamauchi, Yohei -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):473-7. doi: 10.1126/science.1257037.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biochemistry, Eidgenossische Technische Hochschule (ETH) Zurich, Switzerland. ; Epigenetics, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. ; Institute of Molecular Health Sciences, ETH Zurich, Switzerland. ; Synthetic and Systems Biology Unit, Biological Research Center, Szeged, Hungary. ; Epigenetics, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Faculty of Sciences, University of Basel, Basel, Switzerland. ; Institute of Biochemistry, Eidgenossische Technische Hochschule (ETH) Zurich, Switzerland. ari.helenius@bc.biol.ethz.ch yohei.yamauchi@bc.biol.ethz.ch.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342804" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Capsid/*metabolism ; Cell Line, Tumor ; Cell Nucleus/virology ; Dyneins/metabolism ; Gene Knockout Techniques ; Histone Deacetylases/genetics/*physiology ; Host-Pathogen Interactions ; Humans ; Influenza A virus/*physiology ; Influenza, Human/genetics/metabolism/*virology ; Membrane Fusion/genetics/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubule-Associated Proteins/metabolism ; Microtubules/metabolism ; Myosin Type II/metabolism ; Protein Binding ; Protein Folding ; Protein Structure, Tertiary ; RNA Interference ; Ribonucleoproteins/metabolism ; Ubiquitin/chemistry/metabolism ; *Virus Internalization ; Virus Replication
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  • 141
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):722, 724. doi: 10.1126/science.345.6198.722.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124407" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Afghan Campaign 2001- ; Afghanistan/epidemiology ; Bombs ; Humans ; Mortality ; *Warfare ; Wounds and Injuries/*epidemiology
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  • 142
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):151-2. doi: 10.1126/science.346.6206.151.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301596" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Clinical Trials, Phase I as Topic ; Ebola Vaccines/administration & dosage ; Hemorrhagic Fever, Ebola/*epidemiology/*prevention & control ; Humans ; Models, Statistical ; Probability ; Risk ; United States/epidemiology ; World Health Organization
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  • 143
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajsbaum, Ricardo -- Garcia-Sastre, Adolfo -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):427-8. doi: 10.1126/science.1261509.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA. adolfo.garcia-sastre@mssm.edu rirajsba@utmb.edu. ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. adolfo.garcia-sastre@mssm.edu rirajsba@utmb.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342790" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Capsid/*metabolism ; Histone Deacetylases/*physiology ; Humans ; Influenza A virus/*physiology ; Influenza, Human/*virology ; *Virus Internalization
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  • 144
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 23;344(6186):836-7. doi: 10.1126/science.344.6186.836.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855257" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Policy Making ; Social Mobility/*statistics & numerical data/*trends ; Taxes ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 145
    Publikationsdatum: 2014-08-30
    Beschreibung: Ecological set-asides are a promising strategy for conserving biodiversity in human-modified landscapes; however, landowner participation is often precluded by financial constraints. We assessed the ecological benefits and economic costs of paying landowners to set aside private land for restoration. Benefits were calculated from data on nearly 25,000 captures of Brazilian Atlantic Forest vertebrates, and economic costs were estimated for several restoration scenarios and values of payment for ecosystem services. We show that an annual investment equivalent to 6.5% of what Brazil spends on agricultural subsidies would revert species composition and ecological functions across farmlands to levels found inside protected areas, thereby benefiting local people. Hence, efforts to secure the future of this and other biodiversity hotspots may be cost-effective.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Banks-Leite, Cristina -- Pardini, Renata -- Tambosi, Leandro R -- Pearse, William D -- Bueno, Adriana A -- Bruscagin, Roberta T -- Condez, Thais H -- Dixo, Marianna -- Igari, Alexandre T -- Martensen, Alexandre C -- Metzger, Jean Paul -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1041-5. doi: 10.1126/science.1255768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Grand Challenges in the Ecosystem and Environment, Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK. Departamento de Ecologia, Instituto de Biociencias, Universidade de Sao Paulo, 05508-090 Sao Paulo SP, Brazil. c.banks@imperial.ac.uk. ; Departamento de Zoologia, Instituto de Biociencias, Universidade de Sao Paulo, 05508-090 Sao Paulo SP, Brazil. ; Departamento de Ecologia, Instituto de Biociencias, Universidade de Sao Paulo, 05508-090 Sao Paulo SP, Brazil. ; Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN 55108, USA. ; Fundacao Florestal, Rua do Horto 931, 02377-000 Sao Paulo SP, Brazil. ; Departamento de Zoologia, Instituto de Biociencias, Universidade Estadual Paulista, 13506-900 Rio Claro SP, Brazil. ; Curso de Gestao Ambiental, Escola de Artes, Ciencias e Humanidades, Universidade de Sao Paulo, 03828-000 Sao Paulo SP, Brazil. ; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/*economics ; Animals ; *Biodiversity ; Brazil ; Conservation of Natural Resources/*economics ; Cost-Benefit Analysis ; Humans ; Ownership/economics ; Phylogeny ; *Trees ; Vertebrates/*classification
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  • 146
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-12-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1155. doi: 10.1126/science.aaa3796.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt Editor-in-Chief Science Journals.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477433" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Age Factors ; *Bibliometrics ; Humans ; *Personality Assessment ; Research/*economics ; Research Personnel/*trends
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  • 147
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1270-1. doi: 10.1126/science.345.6202.1270.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214608" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anopheles gambiae ; Budgets/trends ; Communicable Diseases, Emerging/economics/*prevention & control ; Disease Eradication/*economics ; Humans ; Insecticide-Treated Bednets/standards/statistics & numerical ; data/trends/utilization ; Malaria/economics/*epidemiology/*prevention & control ; Risk ; Zambia/epidemiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 148
    Publikationsdatum: 2014-05-24
    Beschreibung: Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1 resulted in a profound parasite replication defect. Vaccination of mice with recombinant Plasmodium berghei PbSEA-1 significantly reduced parasitemia and delayed mortality after lethal challenge with the Plasmodium berghei strain ANKA. Tanzanian children with antibodies to recombinant PfSEA-1A (rPfSEA-1A) did not experience severe malaria, and Kenyan adolescents and adults with antibodies to rPfSEA-1A had significantly lower parasite densities than individuals without these antibodies. By blocking schizont egress, PfSEA-1 may synergize with other vaccines targeting hepatocyte and RBC invasion.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raj, Dipak K -- Nixon, Christian P -- Nixon, Christina E -- Dvorin, Jeffrey D -- DiPetrillo, Christen G -- Pond-Tor, Sunthorn -- Wu, Hai-Wei -- Jolly, Grant -- Pischel, Lauren -- Lu, Ailin -- Michelow, Ian C -- Cheng, Ling -- Conteh, Solomon -- McDonald, Emily A -- Absalon, Sabrina -- Holte, Sarah E -- Friedman, Jennifer F -- Fried, Michal -- Duffy, Patrick E -- Kurtis, Jonathan D -- 1K08AI100997-01A1/AI/NIAID NIH HHS/ -- DP2 AI112219/AI/NIAID NIH HHS/ -- DP2-AI112219/AI/NIAID NIH HHS/ -- K08 AI100997/AI/NIAID NIH HHS/ -- P20GM103421/GM/NIGMS NIH HHS/ -- P30 AI042853/AI/NIAID NIH HHS/ -- P30AI042853/AI/NIAID NIH HHS/ -- R01 AI102907/AI/NIAID NIH HHS/ -- R01-AI076353/AI/NIAID NIH HHS/ -- R01-AI102907/AI/NIAID NIH HHS/ -- R01-AI52059/AI/NIAID NIH HHS/ -- T32-DA013911/DA/NIDA NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):871-7. doi: 10.1126/science.1254417.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pediatrics, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. ; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA. ; Fred Hutchinson Cancer Research Center Program in Biostatistics and Biomathematics, Department of Biostatistics and Global Health, University of Washington, Seattle, WA 98109, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. jonathan_kurtis@brown.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855263" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Animals ; Antibodies, Protozoan/blood/*immunology ; Antigens, Protozoan/*immunology ; Child ; Erythrocytes/*parasitology ; Hepatocytes/immunology/parasitology ; Humans ; Immunoglobulin G/blood/immunology ; Kenya ; Malaria/prevention & control ; Malaria Vaccines/*immunology ; Malaria, Falciparum/*prevention & control ; Mice ; Plasmodium berghei/immunology ; Plasmodium falciparum/*growth & development/immunology ; Protozoan Proteins/*immunology ; Recombinant Proteins/immunology ; Schizonts/*growth & development ; Young Adult
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  • 149
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szyszka, Paul -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1454. doi: 10.1126/science.1255748.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Konstanz, 78457 Konstanz, Germany. paul.szyszka@uni-konstanz.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970067" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Datura/*physiology ; Flowers/*physiology ; Male ; Manduca/*physiology ; Neurons/*physiology ; *Odors ; Olfactory Receptor Neurons/*physiology
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  • 150
    Publikationsdatum: 2014-08-30
    Beschreibung: The New World Arctic, the last region of the Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding of its genetic history is lacking. We present genome-wide sequence data from ancient and present-day humans from Greenland, Arctic Canada, Alaska, Aleutian Islands, and Siberia. We show that Paleo-Eskimos (~3000 BCE to 1300 CE) represent a migration pulse into the Americas independent of both Native American and Inuit expansions. Furthermore, the genetic continuity characterizing the Paleo-Eskimo period was interrupted by the arrival of a new population, representing the ancestors of present-day Inuit, with evidence of past gene flow between these lineages. Despite periodic abandonment of major Arctic regions, a single Paleo-Eskimo metapopulation likely survived in near-isolation for more than 4000 years, only to vanish around 700 years ago.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raghavan, Maanasa -- DeGiorgio, Michael -- Albrechtsen, Anders -- Moltke, Ida -- Skoglund, Pontus -- Korneliussen, Thorfinn S -- Gronnow, Bjarne -- Appelt, Martin -- Gullov, Hans Christian -- Friesen, T Max -- Fitzhugh, William -- Malmstrom, Helena -- Rasmussen, Simon -- Olsen, Jesper -- Melchior, Linea -- Fuller, Benjamin T -- Fahrni, Simon M -- Stafford, Thomas Jr -- Grimes, Vaughan -- Renouf, M A Priscilla -- Cybulski, Jerome -- Lynnerup, Niels -- Lahr, Marta Mirazon -- Britton, Kate -- Knecht, Rick -- Arneborg, Jette -- Metspalu, Mait -- Cornejo, Omar E -- Malaspinas, Anna-Sapfo -- Wang, Yong -- Rasmussen, Morten -- Raghavan, Vibha -- Hansen, Thomas V O -- Khusnutdinova, Elza -- Pierre, Tracey -- Dneprovsky, Kirill -- Andreasen, Claus -- Lange, Hans -- Hayes, M Geoffrey -- Coltrain, Joan -- Spitsyn, Victor A -- Gotherstrom, Anders -- Orlando, Ludovic -- Kivisild, Toomas -- Villems, Richard -- Crawford, Michael H -- Nielsen, Finn C -- Dissing, Jorgen -- Heinemeier, Jan -- Meldgaard, Morten -- Bustamante, Carlos -- O'Rourke, Dennis H -- Jakobsson, Mattias -- Gilbert, M Thomas P -- Nielsen, Rasmus -- Willerslev, Eske -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1255832. doi: 10.1126/science.1255832.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen, Denmark. ; Department of Biology, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA 16802, USA. ; Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen, Denmark. ; Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen, Denmark. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. ; Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. ; Arctic Centre at the Ethnographic Collections (SILA), National Museum of Denmark, Frederiksholms Kanal 12, 1220 Copenhagen, Denmark. ; Department of Anthropology, University of Toronto, Toronto, Ontario M5S 2S2, Canada. ; Arctic Studies Center, Post Office Box 37012, Department of Anthropology, MRC 112, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013-7012, USA. ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen, Denmark. Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden. ; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800 Kongens Lyngby, Denmark. ; AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, Denmark. ; Anthropological Laboratory, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V's Vej 11, 2100 Copenhagen, Denmark. ; Department of Earth System Science, University of California, Irvine, CA 92697, USA. ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen, Denmark. AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, Denmark. ; Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada. Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. ; Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada. ; Canadian Museum of History, 100 Rue Laurier, Gatineau, Quebec K1A 0M8, Canada. Department of Anthropology, University of Western Ontario, 1151 Richmond Street North, London N6A 5C2, Canada. ; Leverhulme Centre for Human Evolutionary Studies, Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UK. ; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. Department of Archaeology, University of Aberdeen, St. Mary's Building, Elphinstone Road, Aberdeen AB24 3UF, Scotland, UK. ; Department of Archaeology, University of Aberdeen, St. Mary's Building, Elphinstone Road, Aberdeen AB24 3UF, Scotland, UK. ; National Museum of Denmark, Frederiksholms kanal 12, 1220 Copenhagen, Denmark. School of Geosciences, University of Edinburgh, Edinburgh EH8 9XP, UK. ; Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia. Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia. ; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA. School of Biological Sciences, Washington State University, Post Office Box 644236, Pullman, WA 99164, USA. ; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA. Ancestry.com DNA LLC, San Francisco, CA 94107, USA. ; Informatics and Bio-computing, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, M5G 0A3, Canada. ; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. ; Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Bashkortostan 450074, Russia. ; State Museum for Oriental Art, 12a, Nikitsky Boulevard, Moscow 119019, Russia. ; Greenland National Museum and Archives, Post Office Box 145, 3900 Nuuk, Greenland. ; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Department of Anthropology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208, USA. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. ; Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA. ; Research Centre for Medical Genetics of Russian Academy of Medical Sciences, 1 Moskvorechie, Moscow 115478, Russia. ; Department of Archaeology and Classical Studies, Stockholm University, Stockholm, Sweden. ; Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia. Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UK. ; Laboratory of Biological Anthropology, University of Kansas, Lawrence, KS 66045, USA. ; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA. ; Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden. ; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA. ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 1350 Copenhagen, Denmark. ewillerslev@snm.ku.dk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170159" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alaska/ethnology ; Arctic Regions/ethnology ; Base Sequence ; Bone and Bones ; Canada/ethnology ; DNA, Mitochondrial/genetics ; Genome, Human/*genetics ; Greenland/ethnology ; Hair ; History, Ancient ; *Human Migration ; Humans ; Inuits/ethnology/*genetics/history ; Molecular Sequence Data ; Siberia/ethnology ; Survivors/history ; Tooth
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  • 151
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deaton, Angus -- R24 HD047879/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):783. doi: 10.1126/science.1255661.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Angus Deaton is the Dwight D. Eisenhower Professor of Economics and International Affairs at Princeton University, Princeton, NJ. deaton@princeton.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855227" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Economic Development ; Humans ; Income/*statistics & numerical data/*trends
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 152
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1265. doi: 10.1126/science.345.6202.1265.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214605" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa/epidemiology ; Global Health ; Humans ; Meningitis, Meningococcal/epidemiology/*prevention & control ; Meningococcal Vaccines/*administration & dosage ; World Health Organization
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  • 153
    Publikationsdatum: 2014-10-18
    Beschreibung: Nitrogen (N) is a critical nutrient for plants but is often distributed unevenly in the soil. Plants therefore have evolved a systemic mechanism by which N starvation on one side of the root system leads to a compensatory and increased nitrate uptake on the other side. Here, we study the molecular systems that support perception of N and the long-distance signaling needed to alter root development. Rootlets starved of N secrete small peptides that are translocated to the shoot and received by two leucine-rich repeat receptor kinases (LRR-RKs). Arabidopsis plants deficient in this pathway show growth retardation accompanied with N-deficiency symptoms. Thus, signaling from the root to the shoot helps the plant adapt to fluctuations in local N availability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tabata, Ryo -- Sumida, Kumiko -- Yoshii, Tomoaki -- Ohyama, Kentaro -- Shinohara, Hidefumi -- Matsubayashi, Yoshikatsu -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):343-6. doi: 10.1126/science.1257800.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan. ; Department of Applied Molecular Biosciences, Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. ; Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan. matsu@bio.nagoya-u.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324386" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Arabidopsis/genetics/*growth & development/metabolism ; Arabidopsis Proteins/genetics/*metabolism ; Molecular Sequence Data ; Nitrogen/*metabolism ; Peptides/*metabolism ; Plant Roots/genetics/*growth & development/metabolism ; Plant Shoots/genetics/*growth & development/metabolism ; Receptors, Peptide/genetics/*metabolism ; Signal Transduction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 154
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Vrieze, Jop -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):241-3. doi: 10.1126/science.343.6168.241.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436401" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anthropology ; Diabetes Mellitus, Type 1/immunology/microbiology ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Germ-Free Life ; Health ; Humans ; *Life Style ; Male ; Meat/microbiology ; *Microbiota ; Tanzania
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 155
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-26
    Beschreibung: Proteins that cap the ends of the actin filament are essential regulators of cytoskeleton dynamics. Whereas several proteins cap the rapidly growing barbed end, tropomodulin (Tmod) is the only protein known to cap the slowly growing pointed end. The lack of structural information severely limits our understanding of Tmod's capping mechanism. We describe crystal structures of actin complexes with the unstructured amino-terminal and the leucine-rich repeat carboxy-terminal domains of Tmod. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. We found that Tmod achieves high-affinity binding through several discrete low-affinity interactions, which suggests a mechanism for controlled subunit exchange at the pointed end.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367809/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367809/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rao, Jampani Nageswara -- Madasu, Yadaiah -- Dominguez, Roberto -- GM-0080/GM/NIGMS NIH HHS/ -- R01 GM073791/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 25;345(6195):463-7. doi: 10.1126/science.1256159.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. droberto@mail.med.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25061212" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actin Cytoskeleton/*chemistry ; Actins/*chemistry ; Amino Acid Sequence ; Animals ; Crystallography, X-Ray ; Humans ; Molecular Sequence Data ; Mutation ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rabbits ; Tropomodulin/*chemistry/genetics
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  • 156
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2014 May 23;344(6186):788-9. doi: 10.1126/science.344.6186.788.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855232" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Peer Review, Research/*ethics/*standards ; Psychology, Social/*ethics ; Reproducibility of Results ; *Scientific Misconduct
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 157
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rash, Brian G -- Rakic, Pasko -- DA023999/DA/NIDA NIH HHS/ -- NS014841/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):744-5. doi: 10.1126/science.1250246.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale University, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531964" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Alternative Splicing ; Animals ; Body Patterning/*genetics ; Cerebral Cortex/*embryology ; Humans ; Neural Stem Cells/*physiology ; Receptors, G-Protein-Coupled/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 158
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2014 Feb 28;343(6174):958. doi: 10.1126/science.343.6174.958.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24578557" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aggression ; *Community-Based Participatory Research ; Data Collection/*methods ; Humans ; *Social Behavior ; Social Media/*utilization ; Ukraine ; User-Computer Interface
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 159
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):475. doi: 10.1126/science.343.6170.475.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24482458" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemistry ; Biomedical Research/*methods ; *Crowdsourcing ; Humans ; Laboratories ; Nucleic Acid Conformation ; Online Systems ; RNA/biosynthesis/*chemistry ; Remote Sensing Technology/*methods ; *Video Games
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 160
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1108. doi: 10.1126/science.345.6201.1108.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190771" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa, Western/epidemiology ; *Ebolavirus ; Epidemics ; Hemorrhagic Fever, Ebola/*epidemiology/*prevention & control ; Humans ; Models, Biological
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  • 161
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1262-3. doi: 10.1126/science.345.6202.1262.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Child, Preschool ; Diarrhea/*prevention & control ; *Hand Disinfection ; Humans ; Hygiene ; Peru/epidemiology ; Pneumonia/*prevention & control ; Public Health ; *Soaps
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 162
    Publikationsdatum: 2014-05-09
    Beschreibung: Cross-cultural psychologists have mostly contrasted East Asia with the West. However, this study shows that there are major psychological differences within China. We propose that a history of farming rice makes cultures more interdependent, whereas farming wheat makes cultures more independent, and these agricultural legacies continue to affect people in the modern world. We tested 1162 Han Chinese participants in six sites and found that rice-growing southern China is more interdependent and holistic-thinking than the wheat-growing north. To control for confounds like climate, we tested people from neighboring counties along the rice-wheat border and found differences that were just as large. We also find that modernization and pathogen prevalence theories do not fit the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talhelm, T -- Zhang, X -- Oishi, S -- Shimin, C -- Duan, D -- Lan, X -- Kitayama, S -- New York, N.Y. -- Science. 2014 May 9;344(6184):603-8. doi: 10.1126/science.1246850.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24812395" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Agriculture ; Asian Continental Ancestry Group/*psychology ; China ; Female ; Humans ; *Individuation ; Male ; *Oryza ; *Triticum
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  • 163
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: This Review presents basic facts regarding the long-run evolution of income and wealth inequality in Europe and the United States. Income and wealth inequality was very high a century ago, particularly in Europe, but dropped dramatically in the first half of the 20th century. Income inequality has surged back in the United States since the 1970s so that the United States is much more unequal than Europe today. We discuss possible interpretations and lessons for the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piketty, Thomas -- Saez, Emmanuel -- New York, N.Y. -- Science. 2014 May 23;344(6186):838-43. doi: 10.1126/science.1251936.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, Paris School of Economics, Paris, France. thomas.piketty@psemail.eu. ; Department of Economics, University of California at Berkeley, Berkeley, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855258" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Economic Development ; Europe ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Income/history/*statistics & numerical data/*trends ; Socioeconomic Factors/history ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 164
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Jul 4;345(6192):22-3. doi: 10.1126/science.345.6192.22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24994631" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Brain/drug effects/metabolism ; Clinical Trials, Phase II as Topic ; Humans ; N-Methyl-3,4-methylenedioxyamphetamine/*therapeutic use ; Receptors, Adrenergic/metabolism ; Receptors, Dopamine/metabolism ; Stress Disorders, Post-Traumatic/*drug therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 165
    Publikationsdatum: 2014-09-06
    Beschreibung: Pathogens traverse multiple barriers during infection, including cell membranes. We found that during this transition, pathogens carried covalently attached complement C3 into the cell, triggering immediate signaling and effector responses. Sensing of C3 in the cytosol activated mitochondrial antiviral signaling (MAVS)-dependent signaling cascades and induced proinflammatory cytokine secretion. C3 also flagged viruses for rapid proteasomal degradation, preventing their replication. This system could detect both viral and bacterial pathogens but was antagonized by enteroviruses, such as rhinovirus and poliovirus, which cleave C3 using their 3C protease. The antiviral rupintrivir inhibited 3C protease and prevented C3 cleavage, rendering enteroviruses susceptible to intracellular complement sensing. Thus, complement C3 allows cells to detect and disable pathogens that have invaded the cytosol.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172439/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172439/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tam, Jerry C H -- Bidgood, Susanna R -- McEwan, William A -- James, Leo C -- 281627/European Research Council/International -- MC_U105181010/Medical Research Council/United Kingdom -- U105181010/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1256070. doi: 10.1126/science.1256070. Epub 2014 Sep 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. ; Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. lcj@mrc-lmb.cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190799" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviridae/*immunology ; Adenovirus Infections, Human/*immunology ; Animals ; Antibodies, Viral/immunology ; Complement C3/*immunology ; Cytokines/biosynthesis/genetics ; Dogs ; HEK293 Cells ; Host-Pathogen Interactions/*immunology ; Humans ; *Immunity, Innate ; Interferon Regulatory Factors/metabolism ; NF-kappa B/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ribonucleoproteins/genetics/metabolism ; Signal Transduction ; Transcription Factor AP-1/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 166
    Publikationsdatum: 2014-06-28
    Beschreibung: Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events. We found that knockdown of nucleoside diphosphate kinases (NDPKs) NM23-H1/H2, which produce GTP through adenosine triphosphate (ATP)-driven conversion of guanosine diphosphate (GDP), inhibited dynamin-mediated endocytosis. NM23-H1/H2 localized at clathrin-coated pits and interacted with the proline-rich domain of dynamin. In vitro, NM23-H1/H2 were recruited to dynamin-induced tubules, stimulated GTP-loading on dynamin, and triggered fission in the presence of ATP and GDP. NM23-H4, a mitochondria-specific NDPK, colocalized with mitochondrial dynamin-like OPA1 involved in mitochondria inner membrane fusion and increased GTP-loading on OPA1. Like OPA1 loss of function, silencing of NM23-H4 but not NM23-H1/H2 resulted in mitochondrial fragmentation, reflecting fusion defects. Thus, NDPKs interact with and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficiency.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601533/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601533/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boissan, Mathieu -- Montagnac, Guillaume -- Shen, Qinfang -- Griparic, Lorena -- Guitton, Jerome -- Romao, Maryse -- Sauvonnet, Nathalie -- Lagache, Thibault -- Lascu, Ioan -- Raposo, Graca -- Desbourdes, Celine -- Schlattner, Uwe -- Lacombe, Marie-Lise -- Polo, Simona -- van der Bliek, Alexander M -- Roux, Aurelien -- Chavrier, Philippe -- 311536/European Research Council/International -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1510-5. doi: 10.1126/science.1253768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. Universite Pierre et Marie Curie, University Paris 06, Paris, France. Saint-Antoine Research Center, INSERM UMR-S 938, Paris, France. mathieu.boissan@inserm.fr philippe.chavrier@curie.fr. ; Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. ; Department of Biological Chemistry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA. ; Hospices Civils de Lyon, Pierre Benite, France. Universite de Lyon, Lyon, France. ; Institut Curie, Research Center, Paris, France. Structure and Membrane Compartments, CNRS UMR 144, Paris, France. ; Institut Pasteur, Unite de Biologie des Interactions Cellulaires, Paris, France. ; Quantitative Image Analysis Unit, Institut Pasteur, Paris, France. ; Institut de Biochimie et Genetique Cellulaires-CNRS, Universite Bordeaux 2, Bordeaux, France. ; Universite Grenoble Alpes, Laboratory of Fundamental and Applied Bioenergetics, Grenoble, France. Inserm, U1055, Grenoble, France. ; Universite Pierre et Marie Curie, University Paris 06, Paris, France. Saint-Antoine Research Center, INSERM UMR-S 938, Paris, France. ; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. Dipartimento di Scienze della Salute, Universita' degli Studi di Milano, Milan, Italy. ; Biochemistry Department, University of Geneva, & Swiss National Center for Competence in Research Program Chemical Biology, Geneva, Switzerland. ; Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. mathieu.boissan@inserm.fr philippe.chavrier@curie.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970086" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Animals ; Cell Line ; Cell Membrane/*metabolism ; Coated Pits, Cell-Membrane/metabolism ; Dynamins/*metabolism ; Endocytosis ; GTP Phosphohydrolases/metabolism ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/*metabolism ; Humans ; Intracellular Membranes/metabolism ; Membrane Fusion ; Mitochondria/metabolism ; NM23 Nucleoside Diphosphate Kinases/genetics/*metabolism ; Nucleoside Diphosphate Kinase D/metabolism
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  • 167
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):596-8. doi: 10.1126/science.343.6171.596.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503830" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics/*trends ; Clinical Trials as Topic/economics/trends ; Financing, Organized ; Humans ; *National Institutes of Health (U.S.) ; *Peer Review, Research ; Publications/*statistics & numerical data ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 168
    Publikationsdatum: 2014-02-01
    Beschreibung: Genetic errors in meiosis can lead to birth defects and spontaneous abortions. Checkpoint mechanisms of hitherto unknown nature eliminate oocytes with unrepaired DNA damage, causing recombination-defective mutant mice to be sterile. Here, we report that checkpoint kinase 2 (Chk2 or Chek2), is essential for culling mouse oocytes bearing unrepaired meiotic or induced DNA double-strand breaks (DSBs). Female infertility caused by a meiotic recombination mutation or irradiation was reversed by mutation of Chk2. Both meiotically programmed and induced DSBs trigger CHK2-dependent activation of TRP53 (p53) and TRP63 (p63), effecting oocyte elimination. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DSB damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048839/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048839/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bolcun-Filas, Ewelina -- Rinaldi, Vera D -- White, Michelle E -- Schimenti, John C -- GM45415/GM/NIGMS NIH HHS/ -- R01 GM045415/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):533-6. doi: 10.1126/science.1247671.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24482479" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphatases/genetics/metabolism ; Animals ; Cell Cycle Proteins/genetics/metabolism ; Checkpoint Kinase 2/genetics/*physiology ; *DNA Breaks, Double-Stranded ; Female ; HeLa Cells ; Humans ; Infertility, Female/*genetics/pathology ; Meiosis/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Oocytes/*metabolism/pathology ; Phosphoproteins/*metabolism ; Trans-Activators/*metabolism ; Tumor Suppressor Protein p53/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 169
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanes, Jonathan M -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):309. doi: 10.1126/science.346.6207.309.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography, University of Wisconsin, Milwaukee, Milwaukee, WI 53211, USA. dschinn@thegef.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Air Conditioning ; *Conservation of Natural Resources ; *Gross Domestic Product ; Humans ; *Public Opinion ; *Religion ; *Religion and Science
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 170
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 May 2;344(6183):457-8. doi: 10.1126/science.344.6183.457.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24786052" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Camels/virology ; Communicable Diseases, Emerging/*epidemiology/*transmission/virology ; Coronavirus/genetics/*isolation & purification ; *Disease Outbreaks ; Food Contamination ; Genome, Viral ; Humans ; Meat/virology ; Milk/virology ; Mutation ; Risk Assessment ; Saudi Arabia/epidemiology ; Severe Acute Respiratory Syndrome/*epidemiology/*transmission/virology ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 171
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tarpley, Raymond J -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):136-7. doi: 10.1126/science.343.6167.136-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408416" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anti-Bacterial Agents/*adverse effects ; Antibiotic Prophylaxis/*adverse effects/*veterinary ; *Drug Resistance, Bacterial ; *Guidelines as Topic ; Humans ; *Legislation, Veterinary
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 172
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2014 Jul 4;345(6192):18-23. doi: 10.1126/science.345.6192.18.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24994630" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Affect/drug effects ; Clinical Trials, Phase III as Topic ; Hallucinogens/history/*therapeutic use ; History, 20th Century ; Humans ; Lysergic Acid Diethylamide/administration & dosage/history ; Psilocybine/history/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 173
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rau, Greg H -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):739. doi: 10.1126/science.345.6198.739-c. Epub 2014 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Marine Sciences, University of California, Santa Cruz, CA 95064, USA. ghrau@sbcglobal.net.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124418" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Administrative Personnel ; *Climate Change ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 174
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-12
    Beschreibung: Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4(+) T cells and perhaps other long-lived cellular reservoirs. In this Review, we discuss the role of the immune system in the establishment and maintenance of the latent HIV-1 reservoir. A detailed understanding of how the host immune system shapes the size and distribution of the viral reservoir should lead to the development of a new generation of immune-based therapeutics, which may eventually contribute to a curative intervention.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096716/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096716/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barouch, Dan H -- Deeks, Steven G -- AI078526/AI/NIAID NIH HHS/ -- AI084794/AI/NIAID NIH HHS/ -- AI095985/AI/NIAID NIH HHS/ -- AI096040/AI/NIAID NIH HHS/ -- AI096109/AI/NIAID NIH HHS/ -- AI100663/AI/NIAID NIH HHS/ -- OD011170/OD/NIH HHS/ -- R01 AI084794/AI/NIAID NIH HHS/ -- R01 OD011170/OD/NIH HHS/ -- U19 AI078526/AI/NIAID NIH HHS/ -- U19 AI095985/AI/NIAID NIH HHS/ -- U19 AI096040/AI/NIAID NIH HHS/ -- U19 AI096109/AI/NIAID NIH HHS/ -- UM1 AI100663/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):169-74. doi: 10.1126/science.1255512.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. ; University of California, San Francisco, San Francisco, CA 94110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25013067" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/*immunology/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; CD4-Positive T-Lymphocytes/immunology/virology ; HIV Infections/drug therapy/*immunology/prevention & control ; HIV-1/drug effects/*physiology ; Humans ; Immune System/*virology ; Immunization ; Immunologic Factors/therapeutic use ; *Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 175
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):739. doi: 10.1126/science.345.6198.739-b. Epub 2014 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Editor-in-Chief.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124417" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; *HIV Infections ; Humans ; Male ; *Periodicals as Topic ; *Sex Workers ; *Transgender Persons
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 176
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084783/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084783/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stewart, A Keith -- R01 CA183968/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):256-7. doi: 10.1126/science.1249543.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436409" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antineoplastic Agents/*pharmacology ; Humans ; Ikaros Transcription Factor/*metabolism ; Multiple Myeloma/*metabolism ; Peptide Hydrolases/*metabolism ; Teratogens/*pharmacology ; Thalidomide/*analogs & derivatives/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 177
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-29
    Beschreibung: The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q21. Knowing that such a gene existed and approximately where it lay triggered efforts by public and private groups to clone and sequence it. The press baptized the competition "the race" and reported on it in detail for the next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect on "the race" and its consequences for breast cancer prevention and treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, Mary-Claire -- R01 CA157744/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1462-5. doi: 10.1126/science.1251900.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675952" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): BRCA1 Protein/*genetics/history ; Breast Neoplasms/*genetics/history ; Chromosome Mapping ; Chromosomes, Human, Pair 17/*genetics ; Cloning, Molecular ; Female ; Genetic Linkage ; History, 20th Century ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 178
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-12-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bar-Peled, Liron -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1191-2. doi: 10.1126/science.aaa1808.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Scripps Research Institute, La Jolla, CA 92122, USA. lironbp@scripps.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477447" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acids/*metabolism ; Animals ; *Body Size ; *Cell Enlargement ; *Cell Proliferation ; GTP-Binding Protein Regulators/*metabolism ; Lysosomes/*metabolism ; Monomeric GTP-Binding Proteins/*metabolism ; Multiprotein Complexes/metabolism ; Protein Transport ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 179
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉You, Jia -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1440-1. doi: 10.1126/science.345.6203.1440.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237081" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Communication ; Female ; Humans ; Male ; Research Personnel/*classification/*psychology ; *Science ; Sex Factors ; *Social Media
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 180
    Publikationsdatum: 2014-08-12
    Beschreibung: Phospholipids (PLs) with polyunsaturated acyl chains are extremely abundant in a few specialized cellular organelles such as synaptic vesicles and photoreceptor discs, but their effect on membrane properties is poorly understood. Here, we found that polyunsaturated PLs increased the ability of dynamin and endophilin to deform and vesiculate synthetic membranes. When cells incorporated polyunsaturated fatty acids into PLs, the plasma membrane became more amenable to deformation by a pulling force and the rate of endocytosis was accelerated, in particular, under conditions in which cholesterol was limiting. Molecular dynamics simulations and biochemical measurements indicated that polyunsaturated PLs adapted their conformation to membrane curvature. Thus, by reducing the energetic cost of membrane bending and fission, polyunsaturated PLs may help to support rapid endocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinot, Mathieu -- Vanni, Stefano -- Pagnotta, Sophie -- Lacas-Gervais, Sandra -- Payet, Laurie-Anne -- Ferreira, Thierry -- Gautier, Romain -- Goud, Bruno -- Antonny, Bruno -- Barelli, Helene -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):693-7. doi: 10.1126/science.1255288.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Pharmacologie Moleculaire et Cellulaire, Universite Nice Sophia Antipolis and CNRS, 06560 Valbonne, France. Unite Mixte de Recherche 144, Institut Curie and CNRS, F-75248 Paris, France. ; Institut de Pharmacologie Moleculaire et Cellulaire, Universite Nice Sophia Antipolis and CNRS, 06560 Valbonne, France. ; Centre Commun de Microscopie Appliquee, Universite Nice Sophia Antipolis, Parc Valrose, 06000 Nice, France. ; Signalisation et Transports Ioniques Membranaires, Universite de Poitiers and CNRS, Poitiers, France. ; Unite Mixte de Recherche 144, Institut Curie and CNRS, F-75248 Paris, France. ; Institut de Pharmacologie Moleculaire et Cellulaire, Universite Nice Sophia Antipolis and CNRS, 06560 Valbonne, France. antonny@ipmc.cnrs.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104391" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptor Proteins, Signal Transducing/chemistry/metabolism ; Animals ; Cell Line, Tumor ; Cell Membrane/chemistry/*physiology ; Dynamins/chemistry/metabolism ; *Endocytosis ; Fatty Acids, Unsaturated/chemistry/*physiology ; Humans ; Membranes, Artificial ; Mice ; Molecular Dynamics Simulation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 181
    Publikationsdatum: 2014-05-24
    Beschreibung: Cushing's syndrome is caused by excess cortisol production from the adrenocortical gland. In corticotropin-independent Cushing's syndrome, the excess cortisol production is primarily attributed to an adrenocortical adenoma, in which the underlying molecular pathogenesis has been poorly understood. We report a hotspot mutation (L206R) in PRKACA, which encodes the catalytic subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), in more than 50% of cases with adrenocortical adenomas associated with corticotropin-independent Cushing's syndrome. The L206R PRKACA mutant abolished its binding to the regulatory subunit of PKA (PRKAR1A) that inhibits catalytic activity of PRKACA, leading to constitutive, cAMP-independent PKA activation. These results highlight the major role of cAMP-independent activation of cAMP/PKA signaling by somatic mutations in corticotropin-independent Cushing's syndrome, providing insights into the diagnosis and therapeutics of this syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sato, Yusuke -- Maekawa, Shigekatsu -- Ishii, Ryohei -- Sanada, Masashi -- Morikawa, Teppei -- Shiraishi, Yuichi -- Yoshida, Kenichi -- Nagata, Yasunobu -- Sato-Otsubo, Aiko -- Yoshizato, Tetsuichi -- Suzuki, Hiromichi -- Shiozawa, Yusuke -- Kataoka, Keisuke -- Kon, Ayana -- Aoki, Kosuke -- Chiba, Kenichi -- Tanaka, Hiroko -- Kume, Haruki -- Miyano, Satoru -- Fukayama, Masashi -- Nureki, Osamu -- Homma, Yukio -- Ogawa, Seishi -- New York, N.Y. -- Science. 2014 May 23;344(6186):917-20. doi: 10.1126/science.1252328.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan. ; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sogawa-tky@umin.ac.jp homma-uro@umin.ac.jp. ; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. sogawa-tky@umin.ac.jp homma-uro@umin.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855271" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Cortex Neoplasms/*genetics ; Adrenocortical Adenoma/*genetics ; Adrenocorticotropic Hormone/metabolism ; Animals ; Catalytic Domain/genetics ; Cushing Syndrome/*genetics/metabolism ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*genetics/metabolism ; DNA Mutational Analysis ; GTP-Binding Protein alpha Subunits/genetics ; HEK293 Cells ; Humans ; Mice ; Mutation ; NIH 3T3 Cells ; PC12 Cells ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 182
    Publikationsdatum: 2014-10-04
    Beschreibung: The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. Monitoring the effects of small-molecule ligands on the profiles delineated more than 50 targets for the kinase inhibitor staurosporine. We identified the heme biosynthesis enzyme ferrochelatase as a target of kinase inhibitors and suggest that its inhibition causes the phototoxicity observed with vemurafenib and alectinib. Thermal shifts were also observed for downstream effectors of drug treatment. In live cells, dasatinib induced shifts in BCR-ABL pathway proteins, including CRK/CRKL. Thermal proteome profiling provides an unbiased measure of drug-target engagement and facilitates identification of markers for drug efficacy and toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savitski, Mikhail M -- Reinhard, Friedrich B M -- Franken, Holger -- Werner, Thilo -- Savitski, Maria Falth -- Eberhard, Dirk -- Martinez Molina, Daniel -- Jafari, Rozbeh -- Dovega, Rebecca Bakszt -- Klaeger, Susan -- Kuster, Bernhard -- Nordlund, Par -- Bantscheff, Marcus -- Drewes, Gerard -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany. mikhail.m.savitski@gsk.com marcus.x.bantscheff@gsk.com gerard.c.drewes@gsk.com. ; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany. ; Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. ; Department of Proteomics and Bioanalytics, Technische Universitat Munchen, Emil Erlenmeyer Forum 5, Freising, Germany. German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany. ; Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Centre for Biomedical Structural Biology, Nanyang Technological University, Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25278616" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphatases/metabolism ; Antineoplastic Agents/*pharmacology ; Hot Temperature ; Humans ; K562 Cells ; Ligands ; Protein Binding ; Protein Denaturation ; Protein Stability ; Proteome/*drug effects ; Proteomics/*methods
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  • 183
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-29
    Beschreibung: Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies, most notably tumors of the breast and ovaries. The proteins encoded by these genes have been implicated in a plethora of biochemical interactions and biological functions, confounding attempts to coherently explain how their inactivation promotes carcinogenesis. Here, I argue that tumor suppression by BRCA1 and BRCA2 originates from their fundamental role in controlling the assembly and activity of macromolecular complexes that monitor chromosome duplication, maintenance, and segregation across the cell cycle. A tumor-suppressive role for the BRCA proteins as "chromosome custodians" helps to explain the clinical features of cancer susceptibility after their inactivation, provides foundations for the rational therapy of BRCA-deficient cancers, and offers general insights into the mechanisms opposing early steps in human carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venkitaraman, Ashok R -- G1001521/Medical Research Council/United Kingdom -- G1001522/Medical Research Council/United Kingdom -- MC_U105359877/Medical Research Council/United Kingdom -- MC_UU_12022/1/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1470-5. doi: 10.1126/science.1252230.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675954" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): BRCA1 Protein/genetics/*physiology ; BRCA2 Protein/genetics/*physiology ; Breast Neoplasms/*genetics/pathology ; Carcinogenesis/genetics ; Chromosomal Instability ; Chromosome Aberrations ; Female ; Genes, Tumor Suppressor/*physiology ; Germ-Line Mutation ; Humans ; Models, Genetic ; Organ Specificity/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 184
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-22
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581426/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581426/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lieberman, Paul M -- 096496/Wellcome Trust/United Kingdom -- R01 DE017336/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1323-5. doi: 10.1126/science.1252786.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104-4265, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653027" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Burkitt Lymphoma/virology ; Carcinogenesis ; Epstein-Barr Virus Infections/epidemiology/prevention & control/therapy/*virology ; Genome, Viral ; Herpesvirus 4, Human/genetics/immunology/pathogenicity/*physiology ; Herpesvirus Vaccines/immunology/therapeutic use ; Humans ; Neoplasms/*virology ; Virus Latency
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 185
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: Parental care, including feeding and protection of young, is essential for the survival as well as mental and physical well-being of the offspring. A large variety of parental behaviors has been described across species and sexes, raising fascinating questions about how animals identify the young and how brain circuits drive and modulate parental displays in males and females. Recent studies have begun to uncover a striking antagonistic interplay between brain systems underlying parental care and infant-directed aggression in both males and females, as well as a large range of intrinsic and environmentally driven neural modulation and plasticity. Improved understanding of the neural control of parental interactions in animals should provide novel insights into the complex issue of human parental care in both health and disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230532/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230532/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dulac, Catherine -- O'Connell, Lauren A -- Wu, Zheng -- R01 DC009019/DC/NIDCD NIH HHS/ -- R01 DC013087/DC/NIDCD NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):765-70. doi: 10.1126/science.1253291. Epub 2014 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. dulac@fas.harvard.edu. ; FAS Center for System Biology, Harvard University, Cambridge, MA 02138, USA. ; Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124430" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aggression ; Animals ; Biological Evolution ; Brain/*physiology ; Cues ; Female ; Humans ; Male ; Maternal Behavior/*physiology ; Models, Neurological ; Neural Pathways/physiology ; Neurons/physiology ; *Parenting ; Paternal Behavior/*physiology ; Sensation/*physiology
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  • 186
    Publikationsdatum: 2014-05-03
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360903/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360903/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Humphrey, Jay D -- Milewicz, Dianna M -- Tellides, George -- Schwartz, Martin A -- P01 HL110869/HL/NHLBI NIH HHS/ -- R01 HL109942/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2014 May 2;344(6183):477-9. doi: 10.1126/science.1253026.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, Yale University, New Haven, CT, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24786066" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Aged, 80 and over ; Aorta, Abdominal/*physiopathology/*ultrastructure ; Aortic Aneurysm, Abdominal/*physiopathology ; Blood Pressure ; Extracellular Matrix/*ultrastructure ; Humans ; *Mechanotransduction, Cellular
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 187
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nilsen, Timothy W -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1207-8. doi: 10.1126/science.1249340.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626918" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine/*metabolism ; Animals ; Cell Nucleus/enzymology ; Cytoplasm/enzymology ; Dioxygenases/genetics/metabolism ; Gene Knockdown Techniques ; Humans ; Membrane Proteins/genetics/metabolism ; Methylation ; Methyltransferases/genetics/metabolism ; Mice ; Proteins/genetics/metabolism ; *RNA Stability ; RNA, Messenger/*metabolism ; RNA-Binding Proteins/genetics/metabolism ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 188
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-02
    Beschreibung: Human cognitive aging differs between and is malleable within individuals. In the absence of a strong genetic program, it is open to a host of hazards, such as vascular conditions, metabolic syndrome, and chronic stress, but also open to protective and enhancing factors, such as experience-dependent cognitive plasticity. Longitudinal studies suggest that leading an intellectually challenging, physically active, and socially engaged life may mitigate losses and consolidate gains. Interventions help to identify contexts and mechanisms of successful cognitive aging and give science and society a hint about what would be possible if conditions were different.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lindenberger, Ulman -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):572-8. doi: 10.1126/science.1254403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany. Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359964" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Age Factors ; Aging/*physiology ; Animals ; Behavior ; Brain/*growth & development/ultrastructure ; Cognition/*physiology ; Humans ; Neuronal Plasticity/*physiology
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  • 189
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-31
    Beschreibung: Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1 to 3% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering more than 15 gigabases of introgressed sequence that spans ~20% of the Neandertal genome (false discovery rate = 5%). Analyses of surviving archaic lineages suggest that there were fitness costs to hybridization, admixture occurred both before and after divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes. Our results provide a new avenue for paleogenomics studies, allowing substantial amounts of population-level DNA sequence information to be obtained from extinct groups, even in the absence of fossilized remains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vernot, Benjamin -- Akey, Joshua M -- New York, N.Y. -- Science. 2014 Feb 28;343(6174):1017-21. doi: 10.1126/science.1245938. Epub 2014 Jan 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24476670" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Genetic Variation ; *Genome, Human ; Humans ; Hybridization, Genetic ; Indians, North American/genetics ; Neanderthals/*genetics ; Sequence Analysis, DNA
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  • 190
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Traystman, Richard J -- Herson, Paco S -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):369-70. doi: 10.1126/science.343.6169.369.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Pharmacology, Anesthesiology, Emergency Medicine, and Neurology, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458624" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Experimentation/*standards/*statistics & numerical data ; Animals ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 191
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, Virginia -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1334-7. doi: 10.1126/science.344.6190.1334.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948718" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chiroptera/*physiology ; Female ; Humans ; Male ; Sexual Behavior, Animal/*physiology ; Speech/physiology/radiation effects ; *Vocalization, Animal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 192
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-08
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366878/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366878/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, Christopher M -- Pfeiffer, Julie K -- R01 AI074668/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Nov 7;346(6210):700-1. doi: 10.1126/science.aaa0607. Epub 2014 Nov 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. julie.pfeiffer@utsouthwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25378607" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; B-Lymphocytes/*virology ; Caliciviridae Infections/*immunology ; Enterobacteriaceae/*physiology ; Gastroenteritis/*immunology ; Humans ; Intestines/*microbiology ; Norovirus/*physiology ; *Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 193
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nisbet, Euan G -- Dlugokencky, Edward J -- Bousquet, Philippe -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):493-5. doi: 10.1126/science.1247828.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, Royal Holloway, University of London, Egham TW20 0EX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24482471" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air ; Atmosphere/*chemistry ; *Climate Change ; Coal ; Geography ; Greenhouse Effect/prevention & control ; Humans ; Industry ; Methane/*analysis ; Seasons ; Wetlands
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 194
    Publikationsdatum: 2014-08-30
    Beschreibung: Histone H3 lysine(27)-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental perturbations. Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect variegation in various Drosophila tissues. The histone H3K9 demethylase KDM3B/JHDM2 associates with H3K9M-containing nucleosomes, and its misregulation in Drosophila results in changes of H3K9 methylation levels and heterochromatic silencing defects. We have established histone lysine-to-methionine mutants as robust in vivo tools for inhibiting methylation pathways that also function as biochemical reagents for capturing site-specific histone-modifying enzymes, thus providing molecular insight into chromatin signaling pathways.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508193/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508193/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herz, Hans-Martin -- Morgan, Marc -- Gao, Xin -- Jackson, Jessica -- Rickels, Ryan -- Swanson, Selene K -- Florens, Laurence -- Washburn, Michael P -- Eissenberg, Joel C -- Shilatifard, Ali -- CA R01CA089455/CA/NCI NIH HHS/ -- R01 CA089455/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1065-70. doi: 10.1126/science.1255104.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. ; Saint Louis University School of Medicine, Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis, MO, USA. ; Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. ; Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. ash@northwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Substitution ; Animals ; Chromatin/*metabolism ; Disease Models, Animal ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Gene Silencing ; Glioma/genetics/metabolism ; Heterochromatin/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histones/*genetics/metabolism ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Lysine/*genetics ; Methionine/*genetics ; Methylation ; Mutation ; Signal Transduction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 195
    Publikationsdatum: 2014-08-30
    Beschreibung: The bacteria that colonize humans and our built environments have the potential to influence our health. Microbial communities associated with seven families and their homes over 6 weeks were assessed, including three families that moved their home. Microbial communities differed substantially among homes, and the home microbiome was largely sourced from humans. The microbiota in each home were identifiable by family. Network analysis identified humans as the primary bacterial vector, and a Bayesian method significantly matched individuals to their dwellings. Draft genomes of potential human pathogens observed on a kitchen counter could be matched to the hands of occupants. After a house move, the microbial community in the new house rapidly converged on the microbial community of the occupants' former house, suggesting rapid colonization by the family's microbiota.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337996/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337996/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lax, Simon -- Smith, Daniel P -- Hampton-Marcell, Jarrad -- Owens, Sarah M -- Handley, Kim M -- Scott, Nicole M -- Gibbons, Sean M -- Larsen, Peter -- Shogan, Benjamin D -- Weiss, Sophie -- Metcalf, Jessica L -- Ursell, Luke K -- Vazquez-Baeza, Yoshiki -- Van Treuren, Will -- Hasan, Nur A -- Gibson, Molly K -- Colwell, Rita -- Dantas, Gautam -- Knight, Rob -- Gilbert, Jack A -- DP2 DK098089/DK/NIDDK NIH HHS/ -- DP2-DK-098089/DK/NIDDK NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- R01 HG004872/HG/NHGRI NIH HHS/ -- T32 GM008759/GM/NIGMS NIH HHS/ -- U01 HG004866/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1048-52. doi: 10.1126/science.1254529.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. ; Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. ; Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Computation Institute, University of Chicago, Chicago, IL 60637, USA. ; Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA. ; Department of Bioscience, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA. ; Department of Surgery, University of Chicago Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA. ; Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO 80304, USA. ; Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. ; Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA. ; Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA. Department of Computer Science, University of Colorado at Boulder, Boulder, CO 80304, USA. ; CosmosID, 387 Technology Drive, Suite 3119, College Park, MD 20742, USA. Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland College Park, College Park, MD 20742, USA. ; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. ; Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA. Howard Hughes Medical Institute, Boulder, CO 80309, USA. ; Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA. gilbertjack@anl.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170151" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria/*classification/genetics/pathogenicity ; Beds/microbiology ; *Family ; Floors and Floorcoverings ; Foot/microbiology ; Hand/microbiology ; *Host-Pathogen Interactions ; *Household Articles ; Humans ; Metagenome ; Microbiota/genetics/*physiology ; Nose/microbiology ; Pets/microbiology ; Surface Properties
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 196
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DuRant, Hassan -- You, Jia -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):190-1. doi: 10.1126/science.346.6206.190.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Rescue Work ; Robotics/*instrumentation/*trends ; Work/*trends
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 197
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-16
    Beschreibung: Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191866/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191866/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romero, Roberto -- Dey, Sudhansu K -- Fisher, Susan J -- DA06668/DA/NIDA NIH HHS/ -- HD068524/HD/NICHD NIH HHS/ -- P50 HD055764/HD/NICHD NIH HHS/ -- R01 HD068524/HD/NICHD NIH HHS/ -- R37 HD076253/HD/NICHD NIH HHS/ -- U54 HD055764/HD/NICHD NIH HHS/ -- ZIA HD002400-23/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):760-5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, Wayne State University/the Detroit Medical Center, Detroit, MI, USA. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. romeror@mail.nih.gov. ; Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ; Department of Obstetrics, Gynecology and Reproductive Sciences, Department of Anatomy, and Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124429" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Decidua/physiopathology ; Female ; Fetus/immunology ; Humans ; Immune Tolerance ; Infection/complications/physiopathology ; Inflammation/complications/physiopathology ; Obstetric Labor, Premature/*etiology/physiopathology/*prevention & control ; Placenta/immunology ; Pregnancy ; Syndrome ; Vascular Diseases/complications/physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 198
    Publikationsdatum: 2014-08-02
    Beschreibung: Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences are occasionally mobilized by the L1 machinery, a process called 3' transduction. Because 3' transductions are potentially mutagenic, we explored the extent to which they occur somatically during tumorigenesis. Studying cancer genomes from 244 patients, we found that tumors from 53% of the patients had somatic retrotranspositions, of which 24% were 3' transductions. Fingerprinting of donor L1s revealed that a handful of source L1 elements in a tumor can spawn from tens to hundreds of 3' transductions, which can themselves seed further retrotranspositions. The activity of individual L1 elements fluctuated during tumor evolution and correlated with L1 promoter hypomethylation. The 3' transductions disseminated genes, exons, and regulatory elements to new locations, most often to heterochromatic regions of the genome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tubio, Jose M C -- Li, Yilong -- Ju, Young Seok -- Martincorena, Inigo -- Cooke, Susanna L -- Tojo, Marta -- Gundem, Gunes -- Pipinikas, Christodoulos P -- Zamora, Jorge -- Raine, Keiran -- Menzies, Andrew -- Roman-Garcia, Pablo -- Fullam, Anthony -- Gerstung, Moritz -- Shlien, Adam -- Tarpey, Patrick S -- Papaemmanuil, Elli -- Knappskog, Stian -- Van Loo, Peter -- Ramakrishna, Manasa -- Davies, Helen R -- Marshall, John -- Wedge, David C -- Teague, Jon W -- Butler, Adam P -- Nik-Zainal, Serena -- Alexandrov, Ludmil -- Behjati, Sam -- Yates, Lucy R -- Bolli, Niccolo -- Mudie, Laura -- Hardy, Claire -- Martin, Sancha -- McLaren, Stuart -- O'Meara, Sarah -- Anderson, Elizabeth -- Maddison, Mark -- Gamble, Stephen -- ICGC Breast Cancer Group -- ICGC Bone Cancer Group -- ICGC Prostate Cancer Group -- Foster, Christopher -- Warren, Anne Y -- Whitaker, Hayley -- Brewer, Daniel -- Eeles, Rosalind -- Cooper, Colin -- Neal, David -- Lynch, Andy G -- Visakorpi, Tapio -- Isaacs, William B -- van't Veer, Laura -- Caldas, Carlos -- Desmedt, Christine -- Sotiriou, Christos -- Aparicio, Sam -- Foekens, John A -- Eyfjord, Jorunn Erla -- Lakhani, Sunil R -- Thomas, Gilles -- Myklebost, Ola -- Span, Paul N -- Borresen-Dale, Anne-Lise -- Richardson, Andrea L -- Van de Vijver, Marc -- Vincent-Salomon, Anne -- Van den Eynden, Gert G -- Flanagan, Adrienne M -- Futreal, P Andrew -- Janes, Sam M -- Bova, G Steven -- Stratton, Michael R -- McDermott, Ultan -- Campbell, Peter J -- 088340/Wellcome Trust/United Kingdom -- 091730/Wellcome Trust/United Kingdom -- 14835/Cancer Research UK/United Kingdom -- C5047/A14835/Cancer Research UK/United Kingdom -- G0900871/Medical Research Council/United Kingdom -- P30 CA006973/CA/NCI NIH HHS/ -- WT100183MA/Wellcome Trust/United Kingdom -- Department of Health/United Kingdom -- New York, N.Y. -- Science. 2014 Aug 1;345(6196):1251343. doi: 10.1126/science.1251343.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. ; Department of Physiology, School of Medicine-Center for Resesarch in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Spain. ; Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Department of Clinical Science, University of Bergen, Bergen, Norway. Department of Oncology, Haukeland University Hospital, Bergen, Norway. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Human Genome Laboratory, Department of Human Genetics, VIB and KU Leuven, Leuven, Belgium. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Department of Haematology, University of Cambridge, Cambridge, UK. ; University of Liverpool and HCA Pathology Laboratories, London, UK. ; Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. ; Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK. ; Institute of Cancer Research, Sutton, London, UK. University of East Anglia, Norwich, UK. ; Institute of Cancer Research, Sutton, London, UK. ; Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland. ; Johns Hopkins University, Baltimore, MD, USA. ; Netherlands Cancer Institute, Amsterdam, Netherlands. ; Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium. ; British Columbia Cancer Agency, Vancouver, Canada. ; Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. ; Cancer Research Laboratory, University of Iceland, Reykjavik, Iceland. ; School of Medicine, University of Queensland, Brisbane, Australia. Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia. UQ Centre for Clinical Research, University of Queensland, Brisbane, Australia. ; Universite Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon, France. ; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. ; Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. ; Dana-Farber Cancer Institute, Boston, MA, USA. ; Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. ; Institut Bergonie, 229 cours de l'Argone, 33076 Bordeaux, France. Institut Curie, Department of Tumor Biology, 26 rue d'Ulm, 75248 Paris cedex 05, France. ; Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp, Belgium. ; Royal National Orthopaedic Hospital, Middlesex, UK. UCL Cancer Institute, University College London, London, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. MD Anderson Cancer Center, Houston, TX, USA. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK. Department of Haematology, University of Cambridge, Cambridge, UK. pc8@sanger.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25082706" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carcinogenesis/genetics ; Chromatin/chemistry ; *DNA Transposable Elements ; Exons ; Genome, Human ; Humans ; *Long Interspersed Nucleotide Elements ; Mutagenesis, Insertional ; Neoplasms/*genetics ; *Transduction, Genetic ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 199
    Publikationsdatum: 2014-11-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Francis S -- Heimer, Hakon -- Giedd, Jay N -- Lein, Edward S -- Sestan, Nenad -- Weinberger, Daniel R -- Casey, B J -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):547-9. doi: 10.1126/science.1260497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. ; Schizophrenia Research Forum, Brain and Behavior Research Foundation, Providence, RI 02906, USA. Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ; Division of Child and Adolescent Psychiatry, University of California, San Diego, CA 92123, USA. ; Allen Institute for Brain Science, Seattle, WA 98103, USA. ; Department of Neurobiology and Psychiatry, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. ; Lieber Institute for Brain Development, Baltimore, MD 21205, USA. Department of Psychiatry, Neurology, Neuroscience, and the Institute of Genomic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 20215, USA. ; Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. bjc2002@med.cornell.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359951" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; *Adolescent Behavior ; *Adolescent Development ; Age of Onset ; Brain/*growth & development/physiology ; *Early Medical Intervention ; Humans ; Mental Disorders/diagnosis/epidemiology/*prevention & control ; *Mental Health ; National Institutes of Health (U.S.)/economics ; Neuroimaging ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 200
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buckley, Ralf -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):358. doi: 10.1126/science.344.6182.358-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environment, Griffith University, Gold Coast, QLD 4222, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763570" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Endangered Species ; *Extinction, Biological ; *Lemur ; Male
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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