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  • 1
    Series available for loan
    Series available for loan
    Algues carbonifères et permiennes de l'Arctique canadien (1987)
    Ottawa : Geological Survey of Canada
    Associated volumes
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    Call number: SR 90.0007(342)
    In: Bulletin
    Type of Medium: Series available for loan
    Pages: 143 S. + 3 pl.
    ISBN: 0660920034
    Series Statement: Bulletin / Geological Survey of Canada 342
    Language: French
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 2
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    Nuclear homeostasis in the mammalian cell [Cell Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-05-06
    Description: How cells maintain nuclear shape and position against various intracellular and extracellular forces is not well understood, although defects in nuclear mechanical homeostasis are associated with a variety of human diseases. We estimated the force required to displace and deform the nucleus in adherent living cells with a technique to...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Biogenesis of the pore architecture of a voltage-gated potassium channel [Biophysics and Computational Biology] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-02-23
    Description: The pore domain of voltage-gated potassium (Kv) channels consists of transmembrane helices S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a tertiary reentrant structure between S5 and S6. Using biogenic intermediates, mass tagging (pegylation), and a molecular tape measure, we explored the possibility that the first stages of pore formation occur prior to oligomerization of the transmembrane core. Pegylation of introduced cysteines shows that the pore helix, but not the turret, forms a compact secondary structure in the terminal 20 Å of the ribosomal tunnel. We assessed the tertiary fold of the pore loop in monomeric constructs by determining the relative accessibilities of select cysteines using the kinetics of pegylation. Turret residues are accessible at the extracellular surface. In contrast, pore helix residues are less accessible. All-atom molecular dynamics simulations of a single Kv monomer in a solvated lipid membrane indicate that secondary and tertiary folds are stable over 650 ns. These results are consistent with acquisition of a tertiary reentrant pore architecture at the monomer stage of Kv biogenesis and begin to define a plausible sequence of folding events in the formation of Kv channels.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    The Rhizome of the Multidrug-Resistant Enterobacter aerogenes Genome Reveals How New "Killer Bugs" Are Created because of a Sympatric Lifestyle (2013)
    Oxford University Press
    Details
    Publication Date: 2013-01-19
    Description: Here, we sequenced the 5,419,609 bp circular genome of an Enterobacter aerogenes clinical isolate that killed a patient and was resistant to almost all current antibiotics (except gentamicin) commonly used to treat Enterobacterial infections, including colistin. Genomic and phylogenetic analyses explain the discrepancies of this bacterium and show that its core genome originates from another genus, Klebsiella. Atypical characteristics of this bacterium (i.e., motility, presence of ornithine decarboxylase, and lack of urease activity) are attributed to genomic mosaicism, by acquisition of additional genes, such as the complete 60,582 bp flagellar assembly operon acquired "en bloc" from the genus Serratia. The genealogic tree of the 162,202 bp multidrug-resistant conjugative plasmid shows that it is a chimera of transposons and integrative conjugative elements from various bacterial origins, resembling a rhizome. Moreover, we demonstrate biologically that a G53S mutation in the pmrA gene results in colistin resistance. E. aerogenes has a large RNA population comprising 8 rRNA operons and 87 cognate tRNAs that have the ability to translate transferred genes that use different codons, as exemplified by the significantly different codon usage between genes from the core genome and the "mobilome." On the basis of our findings, the evolution of this bacterium to become a "killer bug" with new genomic repertoires was from three criteria that are "opportunity, power, and usage" to indicate a sympatric lifestyle: "opportunity" to meet other bacteria and exchange foreign sequences since this bacteria was similar to sympatric bacteria; "power" to integrate these foreign sequences such as the acquisition of several mobile genetic elements (plasmids, integrative conjugative element, prophages, transposons, flagellar assembly system, etc.) found in his genome; and "usage" to have the ability to translate these sequences including those from rare codons to serve as a translator of foreign languages.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Lunar precursor effects in the solar wind and terrestrial magnetosphere (2012)
    Wiley
    Details
    Publication Date: 2012-05-02
    Description: The two ARTEMIS probes observe significant precursor activity upstream from the Moon, when magnetically connected to the dayside lunar surface. The most common signature consists of high levels of whistler wave activity near half of the electron cyclotron frequency. This precursor activity extends to distances of many thousands of km, in both the solar wind and terrestrial magnetosphere. In the magnetosphere, electrons reflect from a combination of magnetic and electrostatic fields above the lunar surface, forming loss cone distributions. In the solar wind they generally form conics, as a result of reflection from an obstacle moving with respect to the plasma frame (just as at a shock). The anisotropy associated with these reflected electrons provides the free energy source for the whistlers, with cyclotron resonance conditions met between the reflected source population and Moonward-propagating waves. These waves can in turn affect incoming plasma, and we observe significant perpendicular electron heating and plasma density depletions in some cases. In the magnetosphere, we also observe broadband electrostatic modes driven by beams of secondary electrons and/or photoelectrons accelerated outward from the surface. We also occasionally see waves near the ion cyclotron frequency in the magnetosphere. These lower frequency waves, which may result from the presence of ions of lunar origin, modulate the whistlers described above, as well as the electrons. Taken together, our observations suggest that the presence of the Moon leads to the formation of an upstream region analogous in many ways to the terrestrial electron foreshock.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    A model of electromagnetic electron phase-space holes and its application (2011)
    Wiley
    Details
    Publication Date: 2011-11-16
    Description: Electron phase-space holes (EHs) are indicators of nonlinear activities in space plasmas. Most often they are observed as electrostatic signals, but recently Andersson et al. [2009] reported electromagnetic EHs observed by the THEMIS mission in the Earth's plasma sheet. As a follow-up to Andersson et al. [2009], this paper presents a model of electromagnetic EHs where the δE × B0 drift of electrons creates a net current. The model is examined with test-particle simulations and compared to the electromagnetic EHs reported by Andersson et al. [2009]. As an application of the model, we introduce a more accurate method than the simplified Lorentz transformation of Andersson et al. [2009] to derive EH velocity (vEH). The sizes and potentials of EHs are derived from vEH, so an accurate derivation of vEH is important in analyzing EHs. In general, our results are qualitatively consistent with those of Andersson et al. [2009] but generally with smaller velocities and sizes.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Lightning and plasma wave observations from the galileo flyby of venus (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-09-27
    Description: During the Galileo flyby of Venus the plasma wave instrument was used to search for impulsive radio signals from lightning and to investigate locally generated plasma waves. A total of nine events were detected in the frequency range from 100 kilohertz to 5.6 megahertz. Although the signals are weak, lightning is the only known source of these signals. Near the bow shock two types of locally generated plasma waves were observed, low-frequency electromagnetic waves from about 5 to 50 hertz and electron plasma oscillation at about 45 kilohertz. The plasma oscillations have considerable fine structure, possibly because of the formation of soliton-like wave packets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gurnett, D A -- Kurth, W S -- Roux, A -- Gendrin, R -- Kennel, C F -- Bolton, S J -- New York, N.Y. -- Science. 1991 Sep 27;253(5027):1522-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17784093" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    An observation linking the origin of plasmaspheric hiss to discrete chorus emissions (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-09
    Description: A long-standing problem in the field of space physics has been the origin of plasmaspheric hiss, a naturally occurring electromagnetic wave in the high-density plasmasphere (roughly within 20,000 kilometers of Earth) that is known to remove the high-energy Van Allen Belt electrons that pose a threat to satellites and astronauts. A recent theory tied the origin of plasmaspheric hiss to a seemingly different wave in the outer magnetosphere, but this theory was difficult to test because of a challenging set of observational requirements. Here we report on the experimental verification of the theory, made with a five-satellite NASA mission. This confirmation will allow modeling of plasmaspheric hiss and its effects on the high-energy radiation environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bortnik, J -- Li, W -- Thorne, R M -- Angelopoulos, V -- Cully, C -- Bonnell, J -- Le Contel, O -- Roux, A -- New York, N.Y. -- Science. 2009 May 8;324(5928):775-8. doi: 10.1126/science.1171273.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles, CA 90095, USA. jbortnik@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423824" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-06-28
    Description: Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events. We found that knockdown of nucleoside diphosphate kinases (NDPKs) NM23-H1/H2, which produce GTP through adenosine triphosphate (ATP)-driven conversion of guanosine diphosphate (GDP), inhibited dynamin-mediated endocytosis. NM23-H1/H2 localized at clathrin-coated pits and interacted with the proline-rich domain of dynamin. In vitro, NM23-H1/H2 were recruited to dynamin-induced tubules, stimulated GTP-loading on dynamin, and triggered fission in the presence of ATP and GDP. NM23-H4, a mitochondria-specific NDPK, colocalized with mitochondrial dynamin-like OPA1 involved in mitochondria inner membrane fusion and increased GTP-loading on OPA1. Like OPA1 loss of function, silencing of NM23-H4 but not NM23-H1/H2 resulted in mitochondrial fragmentation, reflecting fusion defects. Thus, NDPKs interact with and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficiency.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601533/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601533/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boissan, Mathieu -- Montagnac, Guillaume -- Shen, Qinfang -- Griparic, Lorena -- Guitton, Jerome -- Romao, Maryse -- Sauvonnet, Nathalie -- Lagache, Thibault -- Lascu, Ioan -- Raposo, Graca -- Desbourdes, Celine -- Schlattner, Uwe -- Lacombe, Marie-Lise -- Polo, Simona -- van der Bliek, Alexander M -- Roux, Aurelien -- Chavrier, Philippe -- 311536/European Research Council/International -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1510-5. doi: 10.1126/science.1253768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. Universite Pierre et Marie Curie, University Paris 06, Paris, France. Saint-Antoine Research Center, INSERM UMR-S 938, Paris, France. mathieu.boissan@inserm.fr philippe.chavrier@curie.fr. ; Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. ; Department of Biological Chemistry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA. ; Hospices Civils de Lyon, Pierre Benite, France. Universite de Lyon, Lyon, France. ; Institut Curie, Research Center, Paris, France. Structure and Membrane Compartments, CNRS UMR 144, Paris, France. ; Institut Pasteur, Unite de Biologie des Interactions Cellulaires, Paris, France. ; Quantitative Image Analysis Unit, Institut Pasteur, Paris, France. ; Institut de Biochimie et Genetique Cellulaires-CNRS, Universite Bordeaux 2, Bordeaux, France. ; Universite Grenoble Alpes, Laboratory of Fundamental and Applied Bioenergetics, Grenoble, France. Inserm, U1055, Grenoble, France. ; Universite Pierre et Marie Curie, University Paris 06, Paris, France. Saint-Antoine Research Center, INSERM UMR-S 938, Paris, France. ; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. Dipartimento di Scienze della Salute, Universita' degli Studi di Milano, Milan, Italy. ; Biochemistry Department, University of Geneva, & Swiss National Center for Competence in Research Program Chemical Biology, Geneva, Switzerland. ; Institut Curie, Research Center, Paris, France. Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France. mathieu.boissan@inserm.fr philippe.chavrier@curie.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970086" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Cell Line ; Cell Membrane/*metabolism ; Coated Pits, Cell-Membrane/metabolism ; Dynamins/*metabolism ; Endocytosis ; GTP Phosphohydrolases/metabolism ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/*metabolism ; Humans ; Intracellular Membranes/metabolism ; Membrane Fusion ; Mitochondria/metabolism ; NM23 Nucleoside Diphosphate Kinases/genetics/*metabolism ; Nucleoside Diphosphate Kinase D/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Radio and plasma wave observations at Saturn from Cassini's approach and first orbit (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-18
    Description: We report data from the Cassini radio and plasma wave instrument during the approach and first orbit at Saturn. During the approach, radio emissions from Saturn showed that the radio rotation period is now 10 hours 45 minutes 45 +/- 36 seconds, about 6 minutes longer than measured by Voyager in 1980 to 1981. In addition, many intense impulsive radio signals were detected from Saturn lightning during the approach and first orbit. Some of these have been linked to storm systems observed by the Cassini imaging instrument. Within the magnetosphere, whistler-mode auroral hiss emissions were observed near the rings, suggesting that a strong electrodynamic interaction is occurring in or near the rings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gurnett, D A -- Kurth, W S -- Hospodarsky, G B -- Persoon, A M -- Averkamp, T F -- Cecconi, B -- Lecacheux, A -- Zarka, P -- Canu, P -- Cornilleau-Wehrlin, N -- Galopeau, P -- Roux, A -- Harvey, C -- Louarn, P -- Bostrom, R -- Gustafsson, G -- Wahlund, J-E -- Desch, M D -- Farrell, W M -- Kaiser, M L -- Goetz, K -- Kellogg, P J -- Fischer, G -- Ladreiter, H-P -- Rucker, H -- Alleyne, H -- Pedersen, A -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1255-9. Epub 2004 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52242, USA. donald-gurnett@uiowa.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604362" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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