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  • Articles  (589)
  • Adult  (324)
  • Chemistry
  • American Association for the Advancement of Science (AAAS)  (577)
  • Tehran University, Kish International Campus  (12)
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  • Articles  (589)
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  • 1
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    Tehran University, Kish International Campus | Kish Island Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Picturesque dragonet ; Adult ; Fish ; Synchiropus picturatus
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 2
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Movement ; Doryrhamphus excisus abbreviatus ; Pipefish ; Fish ; Flag tail Pipefish ; Adult ; Doryrhamphus excisus abbreviatus
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 3
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Fish ; Adult ; Ptereleotris arabica ; Dartfish
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 4
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Iranian Waters ; report ; Tetrosomus gibbosus ; Boxfish ; Fish ; Coral reef ; T. gibbosus ; Adult ; Cowfish ; Humpback ; Turretfish ; Helmet cowfish ; Camel cowfish ; Thornbacked boxfish
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 5
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Ostracion cyanurus ; Boxfish ; Fish ; Adult ; Male ; Female ; Coral reef
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 6
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Chaetodon citrinellus ; Butterflyfish ; Fish ; Adult
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 7
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    Tehran University, Kish International Campus | Tehran, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Synchiropus splendidus ; Fish ; Adult ; Mandarin
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 8
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Blenniella periophthalmus ; Fish ; Adult ; Coral reef ; Blenny ; Male ; Female
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 9
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    Tehran University, Kish International Campus | Tehran, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Blenny ; Petroscirtes mitratus ; Fish ; Adult ; Coral reef
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 10
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    Tehran University, Kish International Campus | Tehran, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Cypraea Ientiginosa ; Gastropoda ; Adult ; Movement ; Life History
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 11
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Fish ; Adult ; Plectroglyphidodon lacrymatus
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 12
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    Tehran University, Kish International Campus | Kish Island, Iran
    Publication Date: 2021-05-19
    Description: Unpublished
    Keywords: Symbiosis ; Symbiosis between Ptereleotris arabica & Cryptocentrus lutheri & Alpheus djiboutensis ; Ptereleotris arabica ; Alpheus djiboutensis ; Cryptocentrus lutheri ; Fish ; Shrimp ; Bentic ; Adult
    Repository Name: AquaDocs
    Type: Images/Video , Non Refereed
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  • 13
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-07-08
    Description: Separation and purification are critical industrial processes for separating components of chemical mixtures, and these processes account for about half of industrial energy usage (1). Gas mixtures of compounds with very similar physical properties are particularly difficult to separate. On pages 137 and 141 of this issue, Cadiau et al. (2) and Cui et al. (3), respectively, show that microporous materials can be designed to have high adsorption capacity and selectivity for particular hydrocarbons, enabling energy-efficient separation. Author: Jerry Y. S. Lin
    Keywords: Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-05-27
    Description: Biomass-degrading microorganisms use lytic polysaccharide monooxygenase (LPMO) enzymes to help digest cellulose, chitin, and starch. By cleaving otherwise inaccessible crystalline cellulose chains, these enzymes provide access to hydrolytic enzymes. LPMOs are of interest to biotechnology because efficient depolymerization of cellulose is a major bottleneck for the production of biologically based chemicals and fuels. On page 1098 of this issue, Kracher et al. (1) compare LPMO-reducing substrates in fungi from different taxonomic groups and lifestyles, based on both biochemical and genomic evidence. The results provide insights into reductive activation of LPMO that are important for developing more efficient industrial enzymes for lignocellulose biorefineries. Author: Angel T. Martínez
    Keywords: Chemistry
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  • 15
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-25
    Description: Author: Marc S. Lavine
    Keywords: Chemistry
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-02-16
    Keywords: Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-02-16
    Description: The comment and response concerning the report of oxidation of methane to methanol by water (Reports, 5 May 2017, p. 523) do not fully capture the implications of thermodynamic limitations. A nonisothermal process in which each cycle requires a large temperature swing and permits only substoichiometric methane conversion surely could not be carried out on any practical scale.
    Keywords: Chemistry
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  • 18
    Publication Date: 2018-02-16
    Description: Labinger argues that stepwise reaction of methane with water to produce methanol and hydrogen will never be commercially feasible because of its substoichiometric basis with respect to the active site and the requirement of a large temperature swing. This comment is not touching any new ground, beyond describing the thermodynamic feasibility, thermal cycling, and the role of water as discussed previously. Most important, it does not have a solid numerical basis.
    Keywords: Chemistry
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  • 19
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-07-27
    Keywords: Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
    Publication Date: 2018-07-27
    Description: Vinyl carbocations have been the subject of extensive experimental and theoretical studies over the past five decades. Despite this long history in chemistry, the utility of vinyl cations in chemical synthesis has been limited, with most reactivity studies focusing on solvolysis reactions or intramolecular processes. Here we report synthetic and mechanistic studies of vinyl cations generated through silylium–weakly coordinating anion catalysis. We find that these reactive intermediates undergo mild intermolecular carbon-carbon bond–forming reactions, including carbon-hydrogen (C–H) insertion into unactivated sp 3 C–H bonds and reductive Friedel-Crafts reactions with arenes. Moreover, we conducted computational studies of these alkane C–H functionalization reactions and discovered that they proceed through nonclassical, ambimodal transition structures. This reaction manifold provides a framework for the catalytic functionalization of hydrocarbons using simple ketone derivatives.
    Keywords: Chemistry
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  • 21
    Publication Date: 2018-06-22
    Description: It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.
    Keywords: Chemistry
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  • 22
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-06-29
    Keywords: Chemistry
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  • 23
    Publication Date: 2018-12-14
    Description: Theory has established the importance of geometric phase (GP) effects in the adiabatic dynamics of molecular systems with a conical intersection connecting the ground- and excited-state potential energy surfaces, but direct observation of their manifestation in chemical reactions remains a major challenge. Here, we report a high-resolution crossed molecular beams study of the H + HD -〉 H 2 + D reaction at a collision energy slightly above the conical intersection. Velocity map ion imaging revealed fast angular oscillations in product quantum state–resolved differential cross sections in the forward scattering direction for H 2 products at specific rovibrational levels. The experimental results agree with adiabatic quantum dynamical calculations only when the GP effect is included.
    Keywords: Chemistry
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  • 24
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Keywords: Chemistry
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  • 25
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Keywords: Chemistry
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  • 26
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Description: The chemistry of the carbonyl group is essential to modern organic synthesis. The preparation of substituted, enantioenriched 1,3- or 1,5-dicarbonyls is well developed, as their disconnection naturally follows from the intrinsic polarity of the carbonyl group. By contrast, a general enantioselective access to quaternary stereocenters in acyclic 1,4-dicarbonyl systems remains an unresolved problem, despite the tremendous importance of 2,3-substituted 1,4-dicarbonyl motifs in natural products and drug scaffolds. Here we present a broad enantioselective and stereodivergent strategy to access acyclic, polysubstituted 1,4-dicarbonyls via acid-catalyzed [3,3]-sulfonium rearrangement starting from vinyl sulfoxides and ynamides. The stereochemistry at sulfur governs the absolute sense of chiral induction, whereas the double bond geometry dictates the relative configuration of the final products.
    Keywords: Chemistry
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  • 27
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Keywords: Chemistry
    Print ISSN: 0036-8075
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  • 28
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-17
    Description: With the recent soaring production of natural gas, the use of methane and other light hydrocarbon feedstocks as starting materials in synthetic transformations is becoming increasingly economically attractive, although it remains chemically challenging. We report the development of photocatalytic C–H amination, alkylation, and arylation of methane, ethane, and higher alkanes under visible light irradiation at ambient temperature. High catalytic efficiency (turnover numbers up to 2900 for methane and 9700 for ethane) and selectivity were achieved using abundant, inexpensive cerium salts as photocatalysts. Ligand-to-metal charge transfer excitation generated alkoxy radicals from simple alcohols that in turn acted as hydrogen atom transfer catalysts. The mixed-phase gas/liquid reaction was adapted to continuous flow, enabling the efficient use of gaseous feedstocks in scalable photocatalytic transformations.
    Keywords: Chemistry
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  • 29
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-24
    Keywords: Chemistry
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  • 30
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-24
    Keywords: Chemistry
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  • 31
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-31
    Keywords: Chemistry
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  • 32
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-31
    Description: Intrigued by the potential of nanoscale machines, scientists have long attempted to control molecular motion. We monitored the individual 0.7-nanometer steps of a single molecular hopper as it moved in an electric field along a track in a nanopore controlled by a chemical ratchet. The hopper demonstrated characteristics desired in a moving molecule: defined start and end points, processivity, no chemical fuel requirement, directional motion, and external control. The hopper was readily functionalized to carry cargos. For example, a DNA molecule could be ratcheted along the track in either direction, a prerequisite for nanopore sequencing.
    Keywords: Chemistry
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  • 33
    Publication Date: 2018-09-21
    Description: Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of phosphorus(III) [P(III)]–based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur incorporation. The power of this reagent system is demonstrated through the robust and stereocontrolled synthesis of various nucleotidic architectures, including ASOs and CDNs, via an efficient, inexpensive, and operationally simple protocol.
    Keywords: Chemistry
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  • 34
    Publication Date: 2018-09-21
    Description: Here we report an anomalous porous molecular crystal built of C–H···N-bonded double-layered roof-floor components and wall components of a segregatively interdigitated architecture. This complicated porous structure consists of only one type of fully aromatic multijoint molecule carrying three identical dipyridylphenyl wedges. Despite its high symmetry, this molecule accomplishes difficult tasks by using two of its three wedges for roof-floor formation and using its other wedge for wall formation. Although a C–H···N bond is extremely labile, the porous crystal maintains its porosity until thermal breakdown of the C–H···N bonds at 202°C occurs, affording a nonporous polymorph. Though this nonporous crystal survives even at 325°C, it can retrieve the parent porosity under acetonitrile vapor. These findings show how one can translate simplicity into ultrahigh complexity.
    Keywords: Chemistry
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  • 35
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-09-28
    Keywords: Chemistry
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  • 36
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-09-28
    Keywords: Chemistry
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  • 37
    Publication Date: 2018-09-28
    Description: Some of the simplest and most powerful carbon-carbon bond forming strategies take advantage of readily accessible ubiquitous motifs: carbonyls and olefins. Here we report a fundamentally distinct mode of reactivity between carbonyls and olefins that differs from established acid-catalyzed carbonyl-ene, Prins, and carbonyl-olefin metathesis reaction paths. A range of epsilon, zeta-unsaturated ketones undergo Brønsted acid–catalyzed intramolecular cyclization to provide tetrahydrofluorene products via the formation of two new carbon-carbon bonds. Theoretical calculations and accompanying mechanistic studies suggest that this carbocyclization reaction proceeds through the intermediacy of a transient oxetane formed by oxygen atom transfer. The complex polycyclic frameworks in this product class appear as common substructures in organic materials, bioactive natural products, and recently developed pharmaceuticals.
    Keywords: Chemistry
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  • 38
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-09-28
    Description: Alkene aminoarylation with a single, bifunctional reagent is a concise synthetic strategy. We report a catalytic protocol for the addition of arylsulfonylacetamides across electron-rich alkenes with complete anti-Markovnikov regioselectivity and excellent diastereoselectivity to provide 2,2-diarylethylamines. In this process, single-electron alkene oxidation enables carbon-nitrogen bond formation to provide a key benzylic radical poised for a Smiles-Truce 1,5-aryl shift. This reaction is redox-neutral, exhibits broad functional group compatibility, and occurs at room temperature with loss of sulfur dioxide. As this process is driven by visible light, uses readily available starting materials, and demonstrates convergent synthesis, it is well suited for use in a variety of synthetic endeavors.
    Keywords: Chemistry
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  • 39
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-10-05
    Keywords: Chemistry
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  • 40
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-10-05
    Keywords: Chemistry
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  • 41
    Publication Date: 2018-10-05
    Description: Photocatalysis based on optically active, "plasmonic" metal nanoparticles has emerged as a promising approach to facilitate light-driven chemical conversions under far milder conditions than thermal catalysis. However, an understanding of the relation between thermal and electronic excitations has been lacking. We report the substantial light-induced reduction of the thermal activation barrier for ammonia decomposition on a plasmonic photocatalyst. We introduce the concept of a light-dependent activation barrier to account for the effect of light illumination on electronic and thermal excitations in a single unified picture. This framework provides insight into the specific role of hot carriers in plasmon-mediated photochemistry, which is critically important for designing energy-efficient plasmonic photocatalysts.
    Keywords: Chemistry
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  • 42
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-10-12
    Keywords: Chemistry
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  • 43
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-10-12
    Keywords: Chemistry
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  • 44
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-10-12
    Description: Single-electron reduction of a carbonyl to a ketyl enables access to a polarity-reversed platform of reactivity for this cornerstone functional group. However, the synthetic utility of the ketyl radical is hindered by the strong reductants necessary for its generation, which also limit its reactivity to net reductive mechanisms. We report a strategy for net redox-neutral generation and reaction of ketyl radicals. The in situ conversion of aldehydes to α-acetoxy iodides lowers their reduction potential by more than 1 volt, allowing for milder access to the corresponding ketyl radicals and an oxidative termination event. Upon subjecting these iodides to a dimanganese decacarbonyl precatalyst and visible light irradiation, an atom transfer radical addition (ATRA) mechanism affords a broad scope of vinyl iodide products with high Z -selectivity.
    Keywords: Chemistry
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  • 45
    Publication Date: 2018-10-12
    Description: Reactions that form a product with the same reactive functionality as that of one of the starting compounds frequently end in oligomerization. As a salient example, selective aldol coupling of the smallest, though arguably most useful, enolizable aldehyde, acetaldehyde, with just one partner substrate has proven to be extremely challenging. Here, we report a highly enantioselective Mukaiyama aldol reaction with the simple triethylsilyl (TES) and tert -butyldimethylsilyl (TBS) enolates of acetaldehyde and various aliphatic and aromatic acceptor aldehydes. The reaction is catalyzed by recently developed, strongly acidic imidodiphosphorimidates (IDPi), which, like enzymes, display a confined active site but, like small-molecule catalysts, have a broad substrate scope. The process is scalable, fast, efficient (0.5 to 1.5 mole % catalyst loading), and greatly simplifies access to highly valuable silylated acetaldehyde aldols.
    Keywords: Chemistry
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  • 46
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-12-21
    Keywords: Chemistry
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    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
    Publication Date: 2018-12-21
    Description: Single-molecule magnets (SMMs) containing only one metal center may represent the lower size limit for molecule-based magnetic information storage materials. Their current drawback is that all SMMs require liquid-helium cooling to show magnetic memory effects. We now report a chemical strategy to access the dysprosium metallocene cation [(Cp i Pr5 )Dy(Cp*)] + (Cp i Pr5 , penta-iso-propylcyclopentadienyl; Cp *, pentamethylcyclopentadienyl), which displays magnetic hysteresis above liquid-nitrogen temperatures. An effective energy barrier to reversal of the magnetization of U eff = 1541 wave number is also measured. The magnetic blocking temperature of T B = 80 kelvin for this cation overcomes an essential barrier toward the development of nanomagnet devices that function at practical temperatures.
    Keywords: Chemistry
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):374-5. doi: 10.1126/science.329.5990.374. Epub 2010 Jul 19.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20643914" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/administration & dosage/*analogs & derivatives/therapeutic use ; Adolescent ; Adult ; Anti-HIV Agents/*administration & dosage/therapeutic use ; Anti-Infective Agents, Local/*administration & dosage/therapeutic use ; Female ; HIV Infections/*prevention & control/*transmission ; *HIV-1/drug effects ; Humans ; Medication Adherence ; Organophosphonates/*administration & dosage/*therapeutic use ; Randomized Controlled Trials as Topic ; South Africa ; Tenofovir ; Vaginal Creams, Foams, and Jellies/administration & dosage/therapeutic use ; Young Adult
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marder, Jenny -- New York, N.Y. -- Science. 2010 Jun 18;328(5985):1474-5. doi: 10.1126/science.328.5985.1474.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20558684" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Alcohol Oxidoreductases/genetics/metabolism ; Antineoplastic Agents/*adverse effects/metabolism ; Child ; Genetic Predisposition to Disease ; Humans ; Neoplasms/*drug therapy/*radiotherapy ; Neoplasms, Second Primary/etiology ; Radiation Injuries/*etiology ; Radiotherapy/adverse effects ; Survivors ; Time Factors ; Young Adult
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2010-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregg, Christopher -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):770-1. doi: 10.1126/science.1199054.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. cgregg@MCB.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051625" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Awards and Prizes ; *Fathers ; *Gene Expression ; Gene Expression Profiling ; *Genomic Imprinting ; Humans ; Interleukin-18 ; Mice ; Mice, Inbred C57BL ; *Mothers ; Polymorphism, Single Nucleotide ; Prefrontal Cortex/embryology/growth & development/*metabolism ; Preoptic Area/embryology/growth & development/*metabolism ; Sex Characteristics
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  • 51
    Publication Date: 2010-09-11
    Description: Group functional connectivity magnetic resonance imaging (fcMRI) studies have documented reliable changes in human functional brain maturity over development. Here we show that support vector machine-based multivariate pattern analysis extracts sufficient information from fcMRI data to make accurate predictions about individuals' brain maturity across development. The use of only 5 minutes of resting-state fcMRI data from 238 scans of typically developing volunteers (ages 7 to 30 years) allowed prediction of individual brain maturity as a functional connectivity maturation index. The resultant functional maturation curve accounted for 55% of the sample variance and followed a nonlinear asymptotic growth curve shape. The greatest relative contribution to predicting individual brain maturity was made by the weakening of short-range functional connections between the adult brain's major functional networks.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135376/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135376/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dosenbach, Nico U F -- Nardos, Binyam -- Cohen, Alexander L -- Fair, Damien A -- Power, Jonathan D -- Church, Jessica A -- Nelson, Steven M -- Wig, Gagan S -- Vogel, Alecia C -- Lessov-Schlaggar, Christina N -- Barnes, Kelly Anne -- Dubis, Joseph W -- Feczko, Eric -- Coalson, Rebecca S -- Pruett, John R Jr -- Barch, Deanna M -- Petersen, Steven E -- Schlaggar, Bradley L -- DA027046/DA/NIDA NIH HHS/ -- EY16336/EY/NEI NIH HHS/ -- HD057076/HD/NICHD NIH HHS/ -- MH62130/MH/NIMH NIH HHS/ -- NS00169011/NS/NINDS NIH HHS/ -- NS053425/NS/NINDS NIH HHS/ -- NS32979/NS/NINDS NIH HHS/ -- NS41255/NS/NINDS NIH HHS/ -- NS46424/NS/NINDS NIH HHS/ -- NS51281/NS/NINDS NIH HHS/ -- NS55582/NS/NINDS NIH HHS/ -- R01 HD057076/HD/NICHD NIH HHS/ -- R01 HD057076-04/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 10;329(5997):1358-61. doi: 10.1126/science.1194144.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. ndosenbach@wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829489" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aging ; Algorithms ; Artificial Intelligence ; Brain/*growth & development/*physiology ; Brain Mapping ; Cerebellum/growth & development/physiology ; Child ; Female ; Frontal Lobe/growth & development/physiology ; Humans ; *Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Neural Pathways ; Occipital Lobe/growth & development/physiology ; Young Adult
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  • 52
    Publication Date: 2010-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Martin D -- Asche, Frank -- Guttormsen, Atle G -- Wiener, Jonathan B -- New York, N.Y. -- Science. 2010 Nov 19;330(6007):1052-3. doi: 10.1126/science.1197769.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nicholas School of the Environment, Duke University, Durham, NC 27708, USA. marsmith@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097923" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; *Animals, Genetically Modified ; Animals, Wild ; Dietary Proteins ; Environment ; Fisheries/economics ; *Food, Genetically Modified/economics ; Humans ; Legislation, Food ; Marketing ; Perciformes/genetics ; Public Health ; *Risk Assessment/methods/standards ; Salmo salar/*genetics ; Salmon/genetics ; United States ; United States Food and Drug Administration
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  • 53
    Publication Date: 2010-07-21
    Description: The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the prevention of HIV acquisition in women. A double-blind, randomized controlled trial was conducted comparing tenofovir gel (n = 445 women) with placebo gel (n = 444 women) in sexually active, HIV-uninfected 18- to 40-year-old women in urban and rural KwaZulu-Natal, South Africa. HIV serostatus, safety, sexual behavior, and gel and condom use were assessed at monthly follow-up visits for 30 months. HIV incidence in the tenofovir gel arm was 5.6 per 100 women-years (person time of study observation) (38 out of 680.6 women-years) compared with 9.1 per 100 women-years (60 out of 660.7 women-years) in the placebo gel arm (incidence rate ratio = 0.61; P = 0.017). In high adherers (gel adherence 〉 80%), HIV incidence was 54% lower (P = 0.025) in the tenofovir gel arm. In intermediate adherers (gel adherence 50 to 80%) and low adherers (gel adherence 〈 50%), the HIV incidence reduction was 38 and 28%, respectively. Tenofovir gel reduced HIV acquisition by an estimated 39% overall, and by 54% in women with high gel adherence. No increase in the overall adverse event rates was observed. There were no changes in viral load and no tenofovir resistance in HIV seroconverters. Tenofovir gel could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001187/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001187/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdool Karim, Quarraisha -- Abdool Karim, Salim S -- Frohlich, Janet A -- Grobler, Anneke C -- Baxter, Cheryl -- Mansoor, Leila E -- Kharsany, Ayesha B M -- Sibeko, Sengeziwe -- Mlisana, Koleka P -- Omar, Zaheen -- Gengiah, Tanuja N -- Maarschalk, Silvia -- Arulappan, Natasha -- Mlotshwa, Mukelisiwe -- Morris, Lynn -- Taylor, Douglas -- CAPRISA 004 Trial Group -- AI51794/AI/NIAID NIH HHS/ -- D43 TW000231/TW/FIC NIH HHS/ -- D43 TW000231-17/TW/FIC NIH HHS/ -- D43TW00231/TW/FIC NIH HHS/ -- U01 AI068619/AI/NIAID NIH HHS/ -- U01AI068633/AI/NIAID NIH HHS/ -- U01AI46749/AI/NIAID NIH HHS/ -- U19 AI051794/AI/NIAID NIH HHS/ -- U19 AI051794-05/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 3;329(5996):1168-74. doi: 10.1126/science.1193748. Epub 2010 Jul 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban 4013, South Africa. caprisa@ukzn.ac.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20643915" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/administration & dosage/adverse effects/*analogs & ; derivatives/therapeutic use ; Administration, Intravaginal ; Adolescent ; Adult ; Anti-HIV Agents/*administration & dosage/adverse effects/therapeutic use ; Anti-Infective Agents, Local/administration & dosage/adverse effects/therapeutic ; use ; Double-Blind Method ; Drug Resistance, Viral ; Female ; HIV Infections/epidemiology/*prevention & control ; HIV-1/*drug effects/physiology ; Humans ; Incidence ; Organophosphonates/*administration & dosage/adverse effects/therapeutic use ; Patient Compliance ; Pregnancy ; Pregnancy Outcome ; Rural Population/statistics & numerical data ; Sexual Behavior ; South Africa/epidemiology ; Tenofovir ; Urban Population/statistics & numerical data ; Vaginal Creams, Foams, and Jellies ; Viral Load ; Young Adult
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  • 54
    Publication Date: 2010-07-31
    Description: Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving. Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161413/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161413/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buckholtz, Joshua W -- Treadway, Michael T -- Cowan, Ronald L -- Woodward, Neil D -- Li, Rui -- Ansari, M Sib -- Baldwin, Ronald M -- Schwartzman, Ashley N -- Shelby, Evan S -- Smith, Clarence E -- Kessler, Robert M -- Zald, David H -- R01 DA019670/DA/NIDA NIH HHS/ -- R01 DA019670-04/DA/NIDA NIH HHS/ -- R01DA019670-04/DA/NIDA NIH HHS/ -- T32 MH018921/MH/NIMH NIH HHS/ -- T32 MH018921-22/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2010 Jul 30;329(5991):532. doi: 10.1126/science.1185778.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA. joshua.buckholtz@vanderbilt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20671181" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Amphetamine-Related Disorders/etiology/metabolism ; Autoreceptors/metabolism ; Benzamides/metabolism ; Corpus Striatum/*metabolism ; Dextroamphetamine/*administration & dosage ; Dopamine/*metabolism ; Female ; Humans ; Impulsive Behavior/*metabolism ; Ligands ; Male ; Positron-Emission Tomography ; Pyrrolidines/metabolism ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/*metabolism ; Signal Transduction ; Substantia Nigra/metabolism ; Tegmentum Mesencephali/*metabolism ; Ventral Tegmental Area/metabolism ; Young Adult
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  • 55
    Publication Date: 2010-04-17
    Description: The anterior prefrontal cortex (APC) confers on humans the ability to simultaneously pursue several goals. How does the brain's motivational system, including the medial frontal cortex (MFC), drive the pursuit of concurrent goals? Using brain imaging, we observed that the left and right MFC, which jointly drive single-task performance according to expected rewards, divide under dual-task conditions: While the left MFC encodes the rewards driving one task, the right MFC concurrently encodes those driving the other task. The same dichotomy was observed in the lateral frontal cortex, whereas the APC combined the rewards driving both tasks. The two frontal lobes thus divide for representing simultaneously two concurrent goals coordinated by the APC. The human frontal function seems limited to driving the pursuit of two concurrent goals simultaneously.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charron, Sylvain -- Koechlin, Etienne -- New York, N.Y. -- Science. 2010 Apr 16;328(5976):360-3. doi: 10.1126/science.1183614.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut National de la Sante et de la Recherche Medicale, Paris F-75654 Cedex 13, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20395509" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Cues ; Female ; Frontal Lobe/*physiology ; *Goals ; Humans ; Magnetic Resonance Imaging ; Male ; Prefrontal Cortex/*physiology ; Psychomotor Performance ; *Reward ; Task Performance and Analysis ; Ventral Tegmental Area/physiology ; Young Adult
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  • 56
    Publication Date: 2010-08-28
    Description: In everyday life, many people believe that two heads are better than one. Our ability to solve problems together appears to be fundamental to the current dominance and future survival of the human species. But are two heads really better than one? We addressed this question in the context of a collective low-level perceptual decision-making task. For two observers of nearly equal visual sensitivity, two heads were definitely better than one, provided they were given the opportunity to communicate freely, even in the absence of any feedback about decision outcomes. But for observers with very different visual sensitivities, two heads were actually worse than the better one. These seemingly discrepant patterns of group behavior can be explained by a model in which two heads are Bayes optimal under the assumption that individuals accurately communicate their level of confidence on every trial.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371582/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371582/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bahrami, Bahador -- Olsen, Karsten -- Latham, Peter E -- Roepstorff, Andreas -- Rees, Geraint -- Frith, Chris D -- 082334/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1081-5. doi: 10.1126/science.1185718.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University College London Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK. bbahrami@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798320" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Bayes Theorem ; *Communication ; *Cooperative Behavior ; *Decision Making ; Feedback, Psychological ; *Group Processes ; Humans ; Male ; Models, Psychological ; Probability ; Psychometrics ; Uncertainty ; *Visual Perception
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  • 57
    Publication Date: 2010-12-15
    Description: The consumption of a food typically leads to a decrease in its subsequent intake through habituation--a decrease in one's responsiveness to the food and motivation to obtain it. We demonstrated that habituation to a food item can occur even when its consumption is merely imagined. Five experiments showed that people who repeatedly imagined eating a food (such as cheese) many times subsequently consumed less of the imagined food than did people who repeatedly imagined eating that food fewer times, imagined eating a different food (such as candy), or did not imagine eating a food. They did so because they desired to eat it less, not because they considered it less palatable. These results suggest that mental representation alone can engender habituation to a stimulus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morewedge, Carey K -- Huh, Young Eun -- Vosgerau, Joachim -- New York, N.Y. -- Science. 2010 Dec 10;330(6010):1530-3. doi: 10.1126/science.1195701.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Social and Decision Sciences, Porter Hall 208, Carnegie Mellon University, Pittsburgh, PA, USA. morewedge@cmu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21148388" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analysis of Variance ; Appetite ; Candy ; Cheese ; *Eating ; *Feeding Behavior ; Female ; Food Preferences ; *Habituation, Psychophysiologic ; Humans ; *Imagination ; Male ; Motivation ; Reinforcement (Psychology) ; Young Adult
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  • 58
    Publication Date: 2011-07-02
    Description: Human memory is strikingly susceptible to social influences, yet we know little about the underlying mechanisms. We examined how socially induced memory errors are generated in the brain by studying the memory of individuals exposed to recollections of others. Participants exhibited a strong tendency to conform to erroneous recollections of the group, producing both long-lasting and temporary errors, even when their initial memory was strong and accurate. Functional brain imaging revealed that social influence modified the neuronal representation of memory. Specifically, a particular brain signature of enhanced amygdala activity and enhanced amygdala-hippocampus connectivity predicted long-lasting but not temporary memory alterations. Our findings reveal how social manipulation can alter memory and extend the known functions of the amygdala to encompass socially mediated memory distortions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edelson, Micah -- Sharot, Tali -- Dolan, Raymond J -- Dudai, Yadin -- 078865/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):108-11. doi: 10.1126/science.1203557.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Israel. micah.edelson@weizmann.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719681" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/*physiology ; Brain Mapping ; Female ; *Group Processes ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; *Mental Recall ; Social Behavior ; *Social Conformity
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  • 59
    Publication Date: 2011-03-12
    Description: The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFalpha-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited selective TNFR binding. PGRN and Atsttrin prevented inflammation in multiple arthritis mouse models and inhibited TNFalpha-activated intracellular signaling. Collectively, these findings demonstrate that PGRN is a ligand of TNFR, an antagonist of TNFalpha signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice. They also suggest new potential therapeutic interventions for various TNFalpha-mediated pathologies and conditions, including rheumatoid arthritis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Wei -- Lu, Yi -- Tian, Qing-Yun -- Zhang, Yan -- Guo, Feng-Jin -- Liu, Guang-Yi -- Syed, Nabeel Muzaffar -- Lai, Yongjie -- Lin, Edward Alan -- Kong, Li -- Su, Jeffrey -- Yin, Fangfang -- Ding, Ai-Hao -- Zanin-Zhorov, Alexandra -- Dustin, Michael L -- Tao, Jian -- Craft, Joseph -- Yin, Zhinan -- Feng, Jian Q -- Abramson, Steven B -- Yu, Xiu-Ping -- Liu, Chuan-ju -- AI43542/AI/NIAID NIH HHS/ -- AR040072/AR/NIAMS NIH HHS/ -- AR050620/AR/NIAMS NIH HHS/ -- AR053210/AR/NIAMS NIH HHS/ -- GM061710/GM/NIGMS NIH HHS/ -- R01 AI030165/AI/NIAID NIH HHS/ -- R01 AI030165-20/AI/NIAID NIH HHS/ -- R01 GM061710/GM/NIGMS NIH HHS/ -- R01 GM061710-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393509" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism/pharmacology/therapeutic use ; Arthritis, Experimental/*drug therapy/*immunology/pathology/physiopathology ; Cartilage, Articular/metabolism/pathology ; Female ; Humans ; Intercellular Signaling Peptides and ; Proteins/chemistry/genetics/*metabolism/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Protein Interaction Domains and Motifs ; Receptors, Tumor Necrosis Factor, Type I/genetics/*metabolism ; Receptors, Tumor Necrosis Factor, Type II/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism/pharmacology/therapeutic use ; Recombinant Proteins/therapeutic use ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology/physiology ; Tumor Necrosis Factor-alpha/*metabolism ; Young Adult
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  • 60
    Publication Date: 2011-05-21
    Description: The transmission of information from DNA to RNA is a critical process. We compared RNA sequences from human B cells of 27 individuals to the corresponding DNA sequences from the same individuals and uncovered more than 10,000 exonic sites where the RNA sequences do not match that of the DNA. All 12 possible categories of discordances were observed. These differences were nonrandom as many sites were found in multiple individuals and in different cell types, including primary skin cells and brain tissues. Using mass spectrometry, we detected peptides that are translated from the discordant RNA sequences and thus do not correspond exactly to the DNA sequences. These widespread RNA-DNA differences in the human transcriptome provide a yet unexplored aspect of genome variation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204392/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204392/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Mingyao -- Wang, Isabel X -- Li, Yun -- Bruzel, Alan -- Richards, Allison L -- Toung, Jonathan M -- Cheung, Vivian G -- R01 HG005854/HG/NHGRI NIH HHS/ -- R01 HG005854-01/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):53-8. doi: 10.1126/science.1207018. Epub 2011 May 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596952" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Amino Acid Sequence ; B-Lymphocytes ; Base Sequence ; Cell Line ; Cerebral Cortex/cytology ; DNA/chemistry/*genetics ; Exons ; Expressed Sequence Tags ; Fibroblasts ; Gene Expression Profiling ; *Genetic Variation ; *Genome, Human ; Genotype ; Humans ; Mass Spectrometry ; Middle Aged ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Protein Biosynthesis ; Proteins/chemistry ; Proteome/chemistry ; RNA, Messenger/chemistry/*genetics ; Sequence Analysis, DNA ; Sequence Analysis, RNA ; Skin/cytology ; Untranslated Regions
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  • 61
    Publication Date: 2011-05-28
    Description: With data from 33 nations, we illustrate the differences between cultures that are tight (have many strong norms and a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of deviant behavior). Tightness-looseness is part of a complex, loosely integrated multilevel system that comprises distal ecological and historical threats (e.g., high population density, resource scarcity, a history of territorial conflict, and disease and environmental threats), broad versus narrow socialization in societal institutions (e.g., autocracy, media regulations), the strength of everyday recurring situations, and micro-level psychological affordances (e.g., prevention self-guides, high regulatory strength, need for structure). This research advances knowledge that can foster cross-cultural understanding in a world of increasing global interdependence and has implications for modeling cultural change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelfand, Michele J -- Raver, Jana L -- Nishii, Lisa -- Leslie, Lisa M -- Lun, Janetta -- Lim, Beng Chong -- Duan, Lili -- Almaliach, Assaf -- Ang, Soon -- Arnadottir, Jakobina -- Aycan, Zeynep -- Boehnke, Klaus -- Boski, Pawel -- Cabecinhas, Rosa -- Chan, Darius -- Chhokar, Jagdeep -- D'Amato, Alessia -- Ferrer, Montse -- Fischlmayr, Iris C -- Fischer, Ronald -- Fulop, Marta -- Georgas, James -- Kashima, Emiko S -- Kashima, Yoshishima -- Kim, Kibum -- Lempereur, Alain -- Marquez, Patricia -- Othman, Rozhan -- Overlaet, Bert -- Panagiotopoulou, Penny -- Peltzer, Karl -- Perez-Florizno, Lorena R -- Ponomarenko, Larisa -- Realo, Anu -- Schei, Vidar -- Schmitt, Manfred -- Smith, Peter B -- Soomro, Nazar -- Szabo, Erna -- Taveesin, Nalinee -- Toyama, Midori -- Van de Vliert, Evert -- Vohra, Naharika -- Ward, Colleen -- Yamaguchi, Susumu -- New York, N.Y. -- Science. 2011 May 27;332(6033):1100-4. doi: 10.1126/science.1197754.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Maryland, College Park, MD 20742, USA. mgelfand@psyc.umd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617077" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Behavior ; *Cross-Cultural Comparison ; *Cultural Characteristics ; Female ; Government ; Humans ; Male ; Permissiveness ; Political Systems ; Population Density ; *Social Behavior ; *Social Conformity ; Social Control, Formal ; *Social Values ; Young Adult
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  • 62
    Publication Date: 2011-01-08
    Description: Emotional tearing is a poorly understood behavior that is considered uniquely human. In mice, tears serve as a chemosignal. We therefore hypothesized that human tears may similarly serve a chemosignaling function. We found that merely sniffing negative-emotion-related odorless tears obtained from women donors induced reductions in sexual appeal attributed by men to pictures of women's faces. Moreover, after sniffing such tears, men experienced reduced self-rated sexual arousal, reduced physiological measures of arousal, and reduced levels of testosterone. Finally, functional magnetic resonance imaging revealed that sniffing women's tears selectively reduced activity in brain substrates of sexual arousal in men.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelstein, Shani -- Yeshurun, Yaara -- Rozenkrantz, Liron -- Shushan, Sagit -- Frumin, Idan -- Roth, Yehudah -- Sobel, Noam -- New York, N.Y. -- Science. 2011 Jan 14;331(6014):226-30. doi: 10.1126/science.1198331. Epub 2011 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212322" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affect ; *Arousal ; Brain/*physiology ; Double-Blind Method ; *Emotions ; Face ; Female ; Humans ; Hypothalamus/physiology ; Magnetic Resonance Imaging ; Male ; Odors ; Pheromones, Human/*analysis ; Saliva/chemistry ; Sex Characteristics ; *Sexual Behavior ; Smell ; Tears/*chemistry ; Temporal Lobe/physiology ; Testosterone/*analysis ; Young Adult
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schenkman, Lauren -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1002-4. doi: 10.1126/science.331.6020.1002.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350139" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Government Regulation ; Humans ; Neoplasms, Radiation-Induced/epidemiology/*etiology/mortality ; Practice Guidelines as Topic ; *Radiation Dosage ; Risk Factors ; Tomography Scanners, X-Ray Computed/*standards ; Tomography, X-Ray Computed/*adverse effects/standards ; United States ; United States Food and Drug Administration
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  • 64
    Publication Date: 2011-08-06
    Description: Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backman, Lars -- Nyberg, Lars -- Soveri, Anna -- Johansson, Jarkko -- Andersson, Micael -- Dahlin, Erika -- Neely, Anna S -- Virta, Jere -- Laine, Matti -- Rinne, Juha O -- New York, N.Y. -- Science. 2011 Aug 5;333(6043):718. doi: 10.1126/science.1204978.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aging Research Center, Karolinska Institute, 171 77 Stockholm, Sweden. lars.backman.1@ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817043" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Corpus Striatum/*metabolism/radionuclide imaging ; Dopamine/*metabolism ; Humans ; *Learning ; Male ; *Memory, Short-Term ; Positron-Emission Tomography ; Raclopride/metabolism ; Receptors, Dopamine D2/*metabolism ; Young Adult
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  • 65
    Publication Date: 2010-12-18
    Description: Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all known protein-coding genes and microRNA genes using Sanger sequencing in a set of 22 MBs. We found that, on average, each tumor had 11 gene alterations, fewer by a factor of 5 to 10 than in the adult solid tumors that have been sequenced to date. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone-lysine N-methyltransferase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110744/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110744/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parsons, D Williams -- Li, Meng -- Zhang, Xiaosong -- Jones, Sian -- Leary, Rebecca J -- Lin, Jimmy Cheng-Ho -- Boca, Simina M -- Carter, Hannah -- Samayoa, Josue -- Bettegowda, Chetan -- Gallia, Gary L -- Jallo, George I -- Binder, Zev A -- Nikolsky, Yuri -- Hartigan, James -- Smith, Doug R -- Gerhard, Daniela S -- Fults, Daniel W -- VandenBerg, Scott -- Berger, Mitchel S -- Marie, Suely Kazue Nagahashi -- Shinjo, Sueli Mieko Oba -- Clara, Carlos -- Phillips, Peter C -- Minturn, Jane E -- Biegel, Jaclyn A -- Judkins, Alexander R -- Resnick, Adam C -- Storm, Phillip B -- Curran, Tom -- He, Yiping -- Rasheed, B Ahmed -- Friedman, Henry S -- Keir, Stephen T -- McLendon, Roger -- Northcott, Paul A -- Taylor, Michael D -- Burger, Peter C -- Riggins, Gregory J -- Karchin, Rachel -- Parmigiani, Giovanni -- Bigner, Darell D -- Yan, Hai -- Papadopoulos, Nick -- Vogelstein, Bert -- Kinzler, Kenneth W -- Velculescu, Victor E -- CA057345/CA/NCI NIH HHS/ -- CA096832/CA/NCI NIH HHS/ -- CA118822/CA/NCI NIH HHS/ -- CA121113/CA/NCI NIH HHS/ -- CA135877/CA/NCI NIH HHS/ -- GM074906-01A1/GM/NIGMS NIH HHS/ -- HHSN261200800001E/PHS HHS/ -- P01 CA096832/CA/NCI NIH HHS/ -- P01 CA096832-03/CA/NCI NIH HHS/ -- R01 CA108622/CA/NCI NIH HHS/ -- R01 CA121113/CA/NCI NIH HHS/ -- R01 CA121113-05/CA/NCI NIH HHS/ -- R37 CA057345/CA/NCI NIH HHS/ -- R37 CA057345-20/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):435-9. doi: 10.1126/science.1198056. Epub 2010 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21163964" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cerebellar Neoplasms/*genetics/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics/metabolism ; *Genes, Neoplasm ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/metabolism ; Methylation ; MicroRNAs/genetics ; *Mutation ; Neoplasm Proteins/genetics/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osotimehin, Babatunde -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):499. doi: 10.1126/science.1210732.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798898" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Contraception ; *Developing Countries ; Family Planning Services ; Female ; Humans ; Population Control ; *Population Growth ; Reproductive Medicine ; *Women's Health ; *Women's Rights
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  • 67
    Publication Date: 2011-11-15
    Description: Although recent psychophysical studies indicate that visual awareness and top-down attention are two distinct processes, it is not clear how they are neurally dissociated in the visual system. Using a two-by-two factorial functional magnetic resonance imaging design with binocular suppression, we found that the visibility or invisibility of a visual target led to only nonsignificant blood oxygenation level-dependent (BOLD) effects in the human primary visual cortex (V1). Directing attention toward and away from the target had much larger and robust effects across all study participants. The difference in the lower-level limit of BOLD activation between attention and awareness illustrates dissociated neural correlates of the two processes. Our results agree with previously reported V1 BOLD effects on attention, while they invite a reconsideration of the functional role of V1 in visual awareness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watanabe, Masataka -- Cheng, Kang -- Murayama, Yusuke -- Ueno, Kenichi -- Asamizuya, Takeshi -- Tanaka, Keiji -- Logothetis, Nikos -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):829-31. doi: 10.1126/science.1203161.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Engineering, University of Tokyo, Tokyo, Japan. watanabe@tuebingen.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076381" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Attention ; *Awareness ; Brain Mapping ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Oxygen/blood ; Photic Stimulation ; Vision, Ocular ; Visual Cortex/*physiology ; Visual Perception/*physiology ; Young Adult
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1513. doi: 10.1126/science.331.6024.1513.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436418" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Bacteriophages/classification/isolation & purification/physiology ; Child ; Child, Preschool ; Diet ; Fever/virology ; Humans ; *Metagenome ; Virus Physiological Phenomena ; *Viruses/classification/isolation & purification
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  • 69
    Publication Date: 2011-12-14
    Description: It is controversial whether the adult primate early visual cortex is sufficiently plastic to cause visual perceptual learning (VPL). The controversy occurs partially because most VPL studies have examined correlations between behavioral and neural activity changes rather than cause-and-effect relationships. With an online-feedback method that uses decoded functional magnetic resonance imaging (fMRI) signals, we induced activity patterns only in early visual cortex corresponding to an orientation without stimulus presentation or participants' awareness of what was to be learned. The induced activation caused VPL specific to the orientation. These results suggest that early visual areas are so plastic that mere inductions of activity patterns are sufficient to cause VPL. This technique can induce plasticity in a highly selective manner, potentially leading to powerful training and rehabilitative protocols.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297423/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297423/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shibata, Kazuhisa -- Watanabe, Takeo -- Sasaki, Yuka -- Kawato, Mitsuo -- R01 AG031941/AG/NIA NIH HHS/ -- R01 AG031941-04/AG/NIA NIH HHS/ -- R01 EY015980/EY/NEI NIH HHS/ -- R01 EY015980-04A2/EY/NEI NIH HHS/ -- R01 EY015980-05/EY/NEI NIH HHS/ -- R01 EY015980-06/EY/NEI NIH HHS/ -- R01 EY015980-07/EY/NEI NIH HHS/ -- R01 EY015980-08/EY/NEI NIH HHS/ -- R01 MH091801/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2011 Dec 9;334(6061):1413-5. doi: 10.1126/science.1212003.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Advanced Telecommunications Research Institute International Computational Neuroscience Laboratories, Keihanna Science City, Kyoto 619-0288, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22158821" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analysis of Variance ; Brain Mapping ; Female ; Humans ; *Learning ; Magnetic Resonance Imaging ; Male ; Neurofeedback ; *Neuronal Plasticity ; Size Perception ; Visual Cortex/*physiology ; *Visual Perception ; Young Adult
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  • 70
    Publication Date: 2011-07-30
    Description: The ability to recognize people by their voice is an important social behavior. Individuals differ in how they pronounce words, and listeners may take advantage of language-specific knowledge of speech phonology to facilitate recognizing voices. Impaired phonological processing is characteristic of dyslexia and thought to be a basis for difficulty in learning to read. We tested voice-recognition abilities of dyslexic and control listeners for voices speaking listeners' native language or an unfamiliar language. Individuals with dyslexia exhibited impaired voice-recognition abilities compared with controls only for voices speaking their native language. These results demonstrate the importance of linguistic representations for voice recognition. Humans appear to identify voices by making comparisons between talkers' pronunciations of words and listeners' stored abstract representations of the sounds in those words.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242590/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242590/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perrachione, Tyler K -- Del Tufo, Stephanie N -- Gabrieli, John D E -- UL1 RR025758/RR/NCRR NIH HHS/ -- UL1RR025758/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):595. doi: 10.1126/science.1207327.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. tkp@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798942" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Dyslexia/*physiopathology ; Female ; Humans ; *Language ; Male ; *Pattern Recognition, Physiological ; *Phonetics ; Speech Perception ; *Voice ; Young Adult
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1488-90. doi: 10.1126/science.334.6062.1488.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22174226" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; BCG Vaccine ; Child ; *Clinical Trials as Topic/economics ; Humans ; *Tuberculosis Vaccines/administration & dosage/economics ; Tuberculosis, Pulmonary/economics/*prevention & control
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  • 72
    Publication Date: 2011-04-09
    Description: Being the victim of discrimination can have serious negative health- and quality-of-life-related consequences. Yet, could being discriminated against depend on such seemingly trivial matters as garbage on the streets? In this study, we show, in two field experiments, that disordered contexts (such as litter or a broken-up sidewalk and an abandoned bicycle) indeed promote stereotyping and discrimination in real-world situations and, in three lab experiments, that it is a heightened need for structure that mediates these effects (number of subjects: between 40 and 70 per experiment). These findings considerably advance our knowledge of the impact of the physical environment on stereotyping and discrimination and have clear policy implications: Diagnose environmental disorder early and intervene immediately.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stapel, Diederik A -- Lindenberg, Siegwart -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):251-3. doi: 10.1126/science.1201068.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tilburg Institute for Behavioral Economics Research, Tilburg University, Post Office Box 90153, 5000 LE Tilburg, Netherlands. d.a.stapel@uvt.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474762" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Psychological ; Adult ; *Environment ; Female ; Humans ; Male ; *Prejudice ; *Stereotyping ; Surveys and Questionnaires ; Young Adult
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2011 Jun 10;332(6035):1249-50. doi: 10.1126/science.332.6035.1249.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21659576" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; DNA, Bacterial ; Disease Outbreaks ; Enterohemorrhagic Escherichia coli/*genetics ; Escherichia coli Infections/epidemiology/*microbiology ; Female ; Gastrointestinal Hemorrhage/microbiology ; *Genome, Bacterial ; Germany/epidemiology ; Hemolytic-Uremic Syndrome/microbiology ; Humans ; Male ; Sequence Analysis, DNA ; Shiga Toxins/genetics
    Print ISSN: 0036-8075
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  • 74
    Publication Date: 2011-06-02
    Description: Members of the gammaretroviruses--such as murine leukemia viruses (MLVs), most notably XMRV [xenotropic murine leukemia virus (X-MLV)-related virus--have been reported to be present in the blood of patients with chronic fatigue syndrome (CFS). We evaluated blood samples from 61 patients with CFS from a single clinical practice, 43 of whom had previously been identified as XMRV-positive. Our analysis included polymerase chain reaction and reverse transcription polymerase chain reaction procedures for detection of viral nucleic acids and assays for detection of infectious virus and virus-specific antibodies. We found no evidence of XMRV or other MLVs in these blood samples. In addition, we found that these gammaretroviruses were strongly (X-MLV) or partially (XMRV) susceptible to inactivation by sera from CFS patients and healthy controls, which suggested that establishment of a successful MLV infection in humans would be unlikely. Consistent with previous reports, we detected MLV sequences in commercial laboratory reagents. Our results indicate that previous evidence linking XMRV and MLVs to CFS is likely attributable to laboratory contamination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knox, Konstance -- Carrigan, Donald -- Simmons, Graham -- Teque, Fernando -- Zhou, Yanchen -- Hackett, John Jr -- Qiu, Xiaoxing -- Luk, Ka-Cheung -- Schochetman, Gerald -- Knox, Allyn -- Kogelnik, Andreas M -- Levy, Jay A -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):94-7. doi: 10.1126/science.1204963. Epub 2011 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wisconsin Viral Research Group, Milwaukee, WI 53226, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21628393" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Base Sequence ; Blood/*virology ; Child ; Child, Preschool ; Complement System Proteins/immunology ; DNA Contamination ; DNA, Viral/blood ; Drug Contamination ; Fatigue Syndrome, Chronic/blood/immunology/*virology ; Female ; Humans ; Indicators and Reagents ; Leukemia Virus, Murine/genetics/isolation & purification ; Leukocytes, Mononuclear/*virology ; Male ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Retroviridae Infections/diagnosis/*virology ; Xenotropic murine leukemia virus-related virus/genetics/immunology/*isolation & ; purification ; Young Adult
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bodereau, Pilar Nores -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):157. doi: 10.1126/science.1212526.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998353" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Air Pollution, Indoor/*prevention & control ; Child, Preschool ; Cooking/*instrumentation ; *Developing Countries ; Female ; *Health Status ; Humans ; Malnutrition/epidemiology/prevention & control ; Organizations ; Peru ; Poverty ; Respiratory Tract Diseases/epidemiology/etiology/*prevention & control ; Smoke/*adverse effects ; United Nations
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):790-2. doi: 10.1126/science.337.6096.790.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22903991" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age of Onset ; Alzheimer Disease/diagnosis/*genetics/*prevention & control ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Apolipoprotein E4/genetics ; Child ; *Clinical Trials as Topic ; DNA Mutational Analysis ; Female ; *Genetic Predisposition to Disease ; Heterozygote Detection ; Humans ; Information Services ; Male ; Pedigree ; Primary Prevention/*methods ; Risk
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2012 May 18;336(6083):790-1. doi: 10.1126/science.336.6083.790.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22605724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Axons/pathology ; Blast Injuries/metabolism/*pathology ; Brain/*pathology ; Brain Chemistry ; Brain Injury, Chronic/metabolism/*pathology ; Humans ; Male ; Mice ; Middle Aged ; *Military Personnel ; *Veterans ; Young Adult ; tau Proteins/analysis
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2012 May 11;336(6082):659. doi: 10.1126/science.336.6082.659.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582235" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Humans ; *Laboratory Infection/epidemiology/microbiology ; Male ; *Meningitis, Meningococcal/epidemiology/microbiology ; *Neisseria meningitidis, Serogroup B/isolation & purification ; San Francisco ; United States/epidemiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2012 Nov 23;338(6110):1026-7. doi: 10.1126/science.338.6110.1026.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23180842" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Female ; Humans ; Mental Disorders/epidemiology ; Middle Aged ; Republic of Korea/epidemiology ; Sex Factors ; Suicide/*statistics & numerical data/*trends ; Young Adult
    Print ISSN: 0036-8075
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  • 80
    Publication Date: 2012-09-29
    Description: In 1990, shotguns and M-16s were adopted into Enga warfare, setting off some 15 years of devastation as youths (~17 to 28) took charge of interclan warfare. In response, people called on elder leaders to adapt customary institutions to restore peace; subsequently, war deaths and the frequency of war declined radically. Data from precolonial warfare, 501 recent wars, and 129 customary court sessions allow us to consider (i) the principles and values behind customary institutions for peace, (ii) their effectiveness, (iii) how they interact with and compare to state institutions of today, and (iv) how such institutions might have shaped our human behavioral repertoire to make life in state societies possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiessner, Polly -- Pupu, Nitze -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1651-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA. wiessner@soft-link.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019648" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Behavior ; Firearms/*statistics & numerical data ; Humans ; Mortality/*trends ; Papua New Guinea ; *Violence ; *Warfare ; Young Adult
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  • 81
    Publication Date: 2012-03-03
    Description: Over 90 capsular serotypes of Streptococcus pneumoniae, a common nasopharyngeal colonizer and major cause of pneumonia, bacteremia, and meningitis, are known. It is unclear why some serotypes can persist at all: They are more easily cleared from carriage and compete poorly in vivo. Serotype-specific immune responses, which could promote diversity in principle, are weak enough to allow repeated colonizations by the same type. We show that weak serotype-specific immunity and an acquired response not specific to the capsule can together reproduce observed diversity. Serotype-specific immunity stabilizes competition, and acquired immunity to noncapsular antigens reduces fitness differences. Our model can be used to explain the effects of pneumococcal vaccination and indicates general factors that regulate the diversity of pathogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341938/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341938/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cobey, Sarah -- Lipsitch, Marc -- 1F32GM097997/GM/NIGMS NIH HHS/ -- 5R01AI048935/AI/NIAID NIH HHS/ -- F32 GM097997/GM/NIGMS NIH HHS/ -- U54 GM088558/GM/NIGMS NIH HHS/ -- U54 GM088558-02/GM/NIGMS NIH HHS/ -- U54GM088558/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1376-80. doi: 10.1126/science.1215947. Epub 2012 Mar 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. scobey@hsph.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383809" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptive Immunity ; Adult ; Antigenic Variation ; Antigens, Bacterial/*immunology ; Bacterial Capsules/immunology ; Carrier State/immunology/*microbiology ; Child ; Child, Preschool ; Computer Simulation ; Humans ; Immunity, Innate ; Infant ; Models, Biological ; Nasopharynx/*microbiology ; Pneumococcal Infections/immunology/*microbiology ; Pneumococcal Vaccines/immunology ; Serotyping ; Streptococcus pneumoniae/classification/*immunology/*physiology ; Time Factors
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-04-28
    Description: Scientific interest in the cognitive underpinnings of religious belief has grown in recent years. However, to date, little experimental research has focused on the cognitive processes that may promote religious disbelief. The present studies apply a dual-process model of cognitive processing to this problem, testing the hypothesis that analytic processing promotes religious disbelief. Individual differences in the tendency to analytically override initially flawed intuitions in reasoning were associated with increased religious disbelief. Four additional experiments provided evidence of causation, as subtle manipulations known to trigger analytic processing also encouraged religious disbelief. Combined, these studies indicate that analytic processing is one factor (presumably among several) that promotes religious disbelief. Although these findings do not speak directly to conversations about the inherent rationality, value, or truth of religious beliefs, they illuminate one cognitive factor that may influence such discussions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gervais, Will M -- Norenzayan, Ara -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):493-6. doi: 10.1126/science.1215647.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of British Columbia, Vancouver, BC, Canada. will@psych.ubc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539725" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cognition ; Female ; Humans ; Intuition ; Male ; *Mental Processes ; *Religion ; *Thinking ; Young Adult
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  • 83
    Publication Date: 2012-10-16
    Description: Every day people make new choices between alternatives that they have never directly experienced. Yet, such decisions are often made rapidly and confidently. Here, we show that the hippocampus, traditionally known for its role in building long-term declarative memories, enables the spread of value across memories, thereby guiding decisions between new choice options. Using functional brain imaging in humans, we discovered that giving people monetary rewards led to activation of a preestablished network of memories, spreading the positive value of reward to nonrewarded items stored in memory. Later, people were biased to choose these nonrewarded items. This decision bias was predicted by activity in the hippocampus, reactivation of associated memories, and connectivity between memory and reward regions in the brain. These findings explain how choices among new alternatives emerge automatically from the associative mechanisms by which the brain builds memories. Further, our findings demonstrate a previously unknown role for the hippocampus in value-based decisions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimmer, G Elliott -- Shohamy, Daphna -- R03-DA026957/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):270-3. doi: 10.1126/science.1223252.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Columbia University, New York, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066083" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Association ; Decision Making/*physiology ; Female ; Hippocampus/*physiology ; Humans ; Memory/*physiology ; Neuroimaging ; *Reward ; Social Values ; Young Adult
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  • 84
    Publication Date: 2013-01-12
    Description: We document that China's One-Child Policy (OCP), one of the most radical approaches to limiting population growth, has produced significantly less trusting, less trustworthy, more risk-averse, less competitive, more pessimistic, and less conscientious individuals. Our data were collected from economics experiments conducted with 421 individuals born just before and just after the OCP's introduction in 1979. Surveys to elicit personality traits were also used. We used the exogenous imposition of the OCP to identify the causal impact of being an only child, net of family background effects. The OCP thus has significant ramifications for Chinese society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, L -- Erkal, N -- Gangadharan, L -- Meng, X -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):953-7. doi: 10.1126/science.1230221. Epub 2013 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Econometrics, Monash University, Clayton, Victoria 3800, Australia. lisa.cameron@monash.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23306438" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Altruism ; Anxiety Disorders ; *Attitude ; *Behavior ; China ; Competitive Behavior ; Family ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; Male ; Only Child/*psychology ; *Personality ; Risk-Taking ; Trust ; Urban Population
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-04-12
    Description: Behavioral economic studies involving limited numbers of choices have provided key insights into neural decision-making mechanisms. By contrast, animals' foraging choices arise in the context of sequences of encounters with prey or food. On each encounter, the animal chooses whether to engage or, if the environment is sufficiently rich, to search elsewhere. The cost of foraging is also critical. We demonstrate that humans can alternate between two modes of choice, comparative decision-making and foraging, depending on distinct neural mechanisms in ventromedial prefrontal cortex (vmPFC) and anterior cingulate cortex (ACC) using distinct reference frames; in ACC, choice variables are represented in invariant reference to foraging or searching for alternatives. Whereas vmPFC encodes values of specific well-defined options, ACC encodes the average value of the foraging environment and cost of foraging.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440844/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440844/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolling, Nils -- Behrens, Timothy E J -- Mars, Rogier B -- Rushworth, Matthew F S -- 088312/Wellcome Trust/United Kingdom -- 089280/Wellcome Trust/United Kingdom -- G0600994/Medical Research Council/United Kingdom -- G0600994(79113)/Medical Research Council/United Kingdom -- G0700399/Medical Research Council/United Kingdom -- G0802146/Medical Research Council/United Kingdom -- G0802146(89549)/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Apr 6;336(6077):95-8. doi: 10.1126/science.1216930.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK. nils.kolling@psy.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22491854" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Choice Behavior ; *Decision Making ; Female ; Gyrus Cinguli/*physiology ; Humans ; Logistic Models ; Male ; Prefrontal Cortex/*physiology ; Reward ; Young Adult
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  • 86
    Publication Date: 2013-07-06
    Description: DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lister, Ryan -- Mukamel, Eran A -- Nery, Joseph R -- Urich, Mark -- Puddifoot, Clare A -- Johnson, Nicholas D -- Lucero, Jacinta -- Huang, Yun -- Dwork, Andrew J -- Schultz, Matthew D -- Yu, Miao -- Tonti-Filippini, Julian -- Heyn, Holger -- Hu, Shijun -- Wu, Joseph C -- Rao, Anjana -- Esteller, Manel -- He, Chuan -- Haghighi, Fatemeh G -- Sejnowski, Terrence J -- Behrens, M Margarita -- Ecker, Joseph R -- AI44432/AI/NIAID NIH HHS/ -- CA151535/CA/NCI NIH HHS/ -- HD065812/HD/NICHD NIH HHS/ -- HG006827/HG/NHGRI NIH HHS/ -- K99NS080911/NS/NINDS NIH HHS/ -- MH094670/MH/NIMH NIH HHS/ -- R01 AI044432/AI/NIAID NIH HHS/ -- R01 CA151535/CA/NCI NIH HHS/ -- R01 HD065812/HD/NICHD NIH HHS/ -- R01 HG006827/HG/NHGRI NIH HHS/ -- R01 MH094670/MH/NIMH NIH HHS/ -- R01 MH094774/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ryan.lister@uwa.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828890" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/metabolism ; Adult ; Animals ; Base Sequence ; Conserved Sequence ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; *Epigenesis, Genetic ; Epigenomics ; Frontal Lobe/*growth & development ; *Gene Expression Regulation, Developmental ; Genome-Wide Association Study ; Humans ; Longevity ; Mice ; Mice, Inbred C57BL ; X Chromosome Inactivation/genetics
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  • 87
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foster, Valerie -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1060-1. doi: 10.1126/science.1230005.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Sciences Division, Pasadena City College, 1570 East Colorado Boulevard, Pasadena, CA 91106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288326" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Courtship/*psychology ; Female ; Humans ; Male ; Marriage/*psychology ; Personality ; Problem-Based Learning/*methods ; Selection, Genetic ; Voice Quality ; Young Adult
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  • 88
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-08-31
    Description: The poor often behave in less capable ways, which can further perpetuate poverty. We hypothesize that poverty directly impedes cognitive function and present two studies that test this hypothesis. First, we experimentally induced thoughts about finances and found that this reduces cognitive performance among poor but not in well-off participants. Second, we examined the cognitive function of farmers over the planting cycle. We found that the same farmer shows diminished cognitive performance before harvest, when poor, as compared with after harvest, when rich. This cannot be explained by differences in time available, nutrition, or work effort. Nor can it be explained with stress: Although farmers do show more stress before harvest, that does not account for diminished cognitive performance. Instead, it appears that poverty itself reduces cognitive capacity. We suggest that this is because poverty-related concerns consume mental resources, leaving less for other tasks. These data provide a previously unexamined perspective and help explain a spectrum of behaviors among the poor. We discuss some implications for poverty policy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, Anandi -- Mullainathan, Sendhil -- Shafir, Eldar -- Zhao, Jiaying -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):976-80. doi: 10.1126/science.1238041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, University of Warwick, Coventry, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990553" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Agriculture ; *Cognition ; Female ; Financial Management ; Humans ; Male ; Poverty/*psychology ; Public Policy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, Lizzie -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):788. doi: 10.1126/science.342.6160.788.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24233700" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alleles ; Diabetes Mellitus/epidemiology/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation ; Genome, Human/*genetics ; Humans ; Male ; Mexico/epidemiology ; Pedigree ; Population/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
    Publication Date: 2013-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- Beachy, Roger -- Baulcombe, David -- Blobel, Gunter -- Datta, Swapan -- Fedoroff, Nina -- Kennedy, Donald -- Khush, Gurdev S -- Peacock, Jim -- Rees, Martin -- Sharp, Phillip -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1320. doi: 10.1126/science.1245017.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052276" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Carotenoids/chemistry/genetics/metabolism ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; *Oryza ; Philippines ; *Plants, Genetically Modified ; Seeds/chemistry/genetics ; Violence/*prevention & control ; Vitamin A/metabolism ; Vitamin A Deficiency/*prevention & control
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
    Publication Date: 2013-08-10
    Description: Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 x 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seder, Robert A -- Chang, Lee-Jah -- Enama, Mary E -- Zephir, Kathryn L -- Sarwar, Uzma N -- Gordon, Ingelise J -- Holman, LaSonji A -- James, Eric R -- Billingsley, Peter F -- Gunasekera, Anusha -- Richman, Adam -- Chakravarty, Sumana -- Manoj, Anita -- Velmurugan, Soundarapandian -- Li, MingLin -- Ruben, Adam J -- Li, Tao -- Eappen, Abraham G -- Stafford, Richard E -- Plummer, Sarah H -- Hendel, Cynthia S -- Novik, Laura -- Costner, Pamela J M -- Mendoza, Floreliz H -- Saunders, Jamie G -- Nason, Martha C -- Richardson, Jason H -- Murphy, Jittawadee -- Davidson, Silas A -- Richie, Thomas L -- Sedegah, Martha -- Sutamihardja, Awalludin -- Fahle, Gary A -- Lyke, Kirsten E -- Laurens, Matthew B -- Roederer, Mario -- Tewari, Kavita -- Epstein, Judith E -- Sim, B Kim Lee -- Ledgerwood, Julie E -- Graham, Barney S -- Hoffman, Stephen L -- VRC 312 Study Team -- 3R44AI055229-06S1/AI/NIAID NIH HHS/ -- 4R44AI055229-08/AI/NIAID NIH HHS/ -- 5R44AI058499-05/AI/NIAID NIH HHS/ -- N01-AI-40096/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929949" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/*administration & dosage/adverse effects/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Mice ; Plasmodium falciparum/*immunology ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects/methods
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  • 92
    Publication Date: 2013-05-21
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Amy L -- Joffe, Steven -- Koenig, Barbara A -- Biesecker, Barbara B -- McCullough, Laurence B -- Blumenthal-Barby, Jennifer S -- Caulfield, Timothy -- Terry, Sharon F -- Green, Robert C -- CA154517/CA/NCI NIH HHS/ -- HG003178/HG/NHGRI NIH HHS/ -- HG005092/HG/NHGRI NIH HHS/ -- HG006485/HG/NHGRI NIH HHS/ -- HG006492/HG/NHGRI NIH HHS/ -- HG006500/HG/NHGRI NIH HHS/ -- HG006612-02/HG/NHGRI NIH HHS/ -- HG006615/HG/NHGRI NIH HHS/ -- HG02213/HG/NHGRI NIH HHS/ -- P20 HG007243/HG/NHGRI NIH HHS/ -- R01 CA154517/CA/NCI NIH HHS/ -- R01 HG002213/HG/NHGRI NIH HHS/ -- R01 HG003178/HG/NHGRI NIH HHS/ -- R01 HG005092/HG/NHGRI NIH HHS/ -- R01-CA154517/CA/NCI NIH HHS/ -- U01 HG006485/HG/NHGRI NIH HHS/ -- U01 HG006492/HG/NHGRI NIH HHS/ -- U01 HG006500/HG/NHGRI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 May 31;340(6136):1047-8. doi: 10.1126/science.1240156. Epub 2013 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23686340" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Disease/*genetics ; *Genetic Predisposition to Disease ; Genetic Testing/ethics/standards ; Genome-Wide Association Study/ethics/standards ; Genomics/*ethics/*standards ; Humans ; *Incidental Findings ; Laboratories/ethics/standards/statistics & numerical data ; Mutation/ethics ; Neoplasms/genetics ; *Practice Guidelines as Topic ; Sequence Analysis, DNA/ethics
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  • 93
    Publication Date: 2013-04-06
    Description: Visual imagery during sleep has long been a topic of persistent speculation, but its private nature has hampered objective analysis. Here we present a neural decoding approach in which machine-learning models predict the contents of visual imagery during the sleep-onset period, given measured brain activity, by discovering links between human functional magnetic resonance imaging patterns and verbal reports with the assistance of lexical and image databases. Decoding models trained on stimulus-induced brain activity in visual cortical areas showed accurate classification, detection, and identification of contents. Our findings demonstrate that specific visual experience during sleep is represented by brain activity patterns shared by stimulus perception, providing a means to uncover subjective contents of dreaming using objective neural measurement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horikawa, T -- Tamaki, M -- Miyawaki, Y -- Kamitani, Y -- New York, N.Y. -- Science. 2013 May 3;340(6132):639-42. doi: 10.1126/science.1234330. Epub 2013 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ATR Computational Neuroscience Laboratories, Kyoto 619-0288, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23558170" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Artificial Intelligence ; Brain/*physiology ; Brain Mapping ; Databases, Factual ; Dreams/*physiology ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Male ; Photic Stimulation ; Sleep/*physiology ; Sleep Stages ; *Support Vector Machine ; Visual Cortex/*physiology ; Visual Perception ; Wakefulness
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  • 94
    Publication Date: 2013-05-25
    Description: The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure. Here, we report that sulfamethoxazole and other sulfa drugs interfere with tetrahydrobiopterin biosynthesis through inhibition of sepiapterin reductase. Crystal structures of sepiapterin reductase with bound sulfa drugs reveal how structurally diverse sulfa drugs achieve specific inhibition of the enzyme. The effect of sulfa drugs on tetrahydrobiopterin-dependent neurotransmitter biosynthesis in cell-based assays provides a rationale for some of their central nervous system-related side effects, particularly in high-dose sulfamethoxazole therapy of Pneumocystis pneumonia. Our findings reveal an unexpected aspect of the pharmacology of sulfa drugs and might translate into their improved medical use.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haruki, Hirohito -- Pedersen, Miriam Gronlund -- Gorska, Katarzyna Irena -- Pojer, Florence -- Johnsson, Kai -- New York, N.Y. -- Science. 2013 May 24;340(6135):987-91. doi: 10.1126/science.1232972.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉EPFL, Institute of Chemical Sciences and Engineering, Institute of Bioengineering, National Centre of Competence in Research in Chemical Biology, 1015 Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704574" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Hydroxytryptophan/biosynthesis ; Adult ; Alcohol Oxidoreductases/*antagonists & inhibitors/*chemistry ; Anti-Infective Agents/adverse effects/*pharmacology/therapeutic use ; Biopterin/*analogs & derivatives/biosynthesis ; Cell Line ; Central Nervous System/drug effects ; Crystallography, X-Ray ; Fibroblasts/drug effects/metabolism ; Humans ; Levodopa/biosynthesis ; NADP/chemistry ; Nausea/chemically induced ; Pneumonia, Pneumocystis/drug therapy ; Protein Conformation ; Structure-Activity Relationship ; Sulfamethoxazole/adverse effects/*pharmacology/therapeutic use ; Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology/therapeutic use ; Vomiting/chemically induced
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  • 95
    Publication Date: 2013-02-23
    Description: The landmark HIV Prevention Trials Network (HPTN) 052 trial in HIV-discordant couples demonstrated unequivocally that treatment with antiretroviral therapy (ART) substantially lowers the probability of HIV transmission to the HIV-uninfected partner. However, it has been vigorously debated whether substantial population-level reductions in the rate of new HIV infections could be achieved in "real-world" sub-Saharan African settings where stable, cohabiting couples are often not the norm and where considerable operational challenges exist to the successful and sustainable delivery of treatment and care to large numbers of patients. We used data from one of Africa's largest population-based prospective cohort studies (in rural KwaZulu-Natal, South Africa) to follow up a total of 16,667 individuals who were HIV-uninfected at baseline, observing individual HIV seroconversions over the period 2004 to 2011. Holding other key HIV risk factors constant, individual HIV acquisition risk declined significantly with increasing ART coverage in the surrounding local community. For example, an HIV-uninfected individual living in a community with high ART coverage (30 to 40% of all HIV-infected individuals on ART) was 38% less likely to acquire HIV than someone living in a community where ART coverage was low (〈10% of all HIV-infected individuals on ART).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255272/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255272/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanser, Frank -- Barnighausen, Till -- Grapsa, Erofili -- Zaidi, Jaffer -- Newell, Marie-Louise -- 082384/Z/07/Z/Wellcome Trust/United Kingdom -- 097410/Wellcome Trust/United Kingdom -- 1R01-HD058482-01/HD/NICHD NIH HHS/ -- R01 HD058482/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):966-71. doi: 10.1126/science.1228160.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Africa Centre for Health and Population Studies, University of KwaZulu-Natal, South Africa. tanserf@africacentre.ac.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430656" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Anti-HIV Agents/*therapeutic use ; *Antiretroviral Therapy, Highly Active ; Delivery of Health Care ; Female ; HIV Infections/*drug therapy/epidemiology/*prevention & control/transmission ; HIV Seropositivity ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; *Rural Health ; South Africa/epidemiology ; Young Adult
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  • 96
    Publication Date: 2013-02-23
    Description: The scale-up of antiretroviral therapy (ART) is expected to raise adult life expectancy in populations with high HIV prevalence. Using data from a population cohort of over 101,000 individuals in rural KwaZulu-Natal, South Africa, we measured changes in adult life expectancy for 2000-2011. In 2003, the year before ART became available in the public-sector health system, adult life expectancy was 49.2 years; by 2011, adult life expectancy had increased to 60.5 years--an 11.3-year gain. Based on standard monetary valuation of life, the survival benefits of ART far outweigh the costs of providing treatment in this community. These gains in adult life expectancy signify the social value of ART and have implications for the investment decisions of individuals, governments, and donors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860268/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860268/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bor, Jacob -- Herbst, Abraham J -- Newell, Marie-Louise -- Barnighausen, Till -- 097410/Wellcome Trust/United Kingdom -- 1R01MH083539-01/MH/NIMH NIH HHS/ -- R01 HD058482-01/HD/NICHD NIH HHS/ -- R01 MH083539/MH/NIMH NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):961-5. doi: 10.1126/science.1230413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Post Office Box 198, Mtubatuba, KwaZulu-Natal 3935, South Africa. jbor@hsph.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430655" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anti-HIV Agents/economics/*therapeutic use ; *Antiretroviral Therapy, Highly Active/economics ; Cohort Studies ; Cost-Benefit Analysis ; Delivery of Health Care ; Female ; HIV Infections/*drug therapy/*mortality ; Humans ; Kaplan-Meier Estimate ; *Life Expectancy/trends ; Male ; Middle Aged ; *Mortality ; Prevalence ; Public Sector ; *Rural Health ; South Africa/epidemiology ; Value of Life ; Young Adult
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  • 97
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-01-05
    Description: We measured the personalities, values, and preferences of more than 19,000 people who ranged in age from 18 to 68 and asked them to report how much they had changed in the past decade and/or to predict how much they would change in the next decade. Young people, middle-aged people, and older people all believed they had changed a lot in the past but would change relatively little in the future. People, it seems, regard the present as a watershed moment at which they have finally become the person they will be for the rest of their lives. This "end of history illusion" had practical consequences, leading people to overpay for future opportunities to indulge their current preferences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quoidbach, Jordi -- Gilbert, Daniel T -- Wilson, Timothy D -- P01 AG020166/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 4;339(6115):96-8. doi: 10.1126/science.1229294.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Fund for Scientific Research, Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23288539" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Female ; *Forecasting ; History ; Humans ; *Illusions ; Male ; Middle Aged ; Personality ; Self Report ; *Time Perception ; Young Adult
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  • 98
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):131. doi: 10.1126/science.339.6116.131.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307715" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; China ; Family Characteristics ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; *Interpersonal Relations ; Male ; Only Child/*psychology ; *Personality ; *Social Behavior ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 May 23;344(6186):793-7. doi: 10.1126/science.344.6186.793.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855236" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antipsychotic Agents/therapeutic use ; *Bioethical Issues ; Conflict of Interest/*economics ; Dibenzothiazepines/therapeutic use ; Drug Industry/economics/ethics ; Ethicists/*psychology ; *Ethics, Medical ; Humans ; Male ; Minnesota ; Quetiapine Fumarate ; Randomized Controlled Trials as Topic/*ethics ; Schizophrenia/drug therapy ; Suicide/*ethics ; Truth Disclosure/*ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2014-07-06
    Description: In 11 studies, we found that participants typically did not enjoy spending 6 to 15 minutes in a room by themselves with nothing to do but think, that they enjoyed doing mundane external activities much more, and that many preferred to administer electric shocks to themselves instead of being left alone with their thoughts. Most people seem to prefer to be doing something rather than nothing, even if that something is negative.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330241/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330241/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Timothy D -- Reinhard, David A -- Westgate, Erin C -- Gilbert, Daniel T -- Ellerbeck, Nicole -- Hahn, Cheryl -- Brown, Casey L -- Shaked, Adi -- T32 MH020006/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 4;345(6192):75-7. doi: 10.1126/science.1250830.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Virginia, Charlottesville, VA, USA. tdw@virginia.edu. ; Department of Psychology, University of Virginia, Charlottesville, VA, USA. ; Department of Psychology, Harvard University, Cambridge, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24994650" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Attention ; Electroshock/psychology ; Humans ; Loneliness/*psychology ; Middle Aged ; *Pleasure ; *Thinking ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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