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  • 1
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    Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-03-16
    Description: Major epidemic outbreaks of viral hepatitis in underdeveloped countries result from a type of non-A, non-B hepatitis distinct from the parenterally transmitted form. The viral agent responsible for this form of epidemic, or enterically transmitted non-A, non-B hepatitis (ET-NANBH), has been serially transmitted in cynomolgus macaques (cynos) and has resulted in typical elevation in liver enzymes and the detection of characteristic virus-like particles (VLPs) in both feces and bile. Infectious bile was used for the construction of recombinant complementary DNA libraries. One clone, ET1.1, was exogenous to uninfected human and cyno genomic liver DNA, as well as to genomic DNA from infected cyno liver. ET1.1 did however, hybridize to an approximately 7.6-kilobase RNA species present only in infected cyno liver. The translated nucleic acid sequence of a portion of ET1.1 had a consensus amino acid motif consistent with an RNA-directed RNA polymerase; this enzyme is present in all positive strand RNA viruses. Furthermore, ET1.1 specifically identified similar sequences in complementary DNA prepared from infected human fecal samples collected from five geographically distinct ET-NANBH outbreaks. Therefore, ET1.1 represents a portion of the genome of the principal viral agent, to be named hepatitis E virus, which is responsible for epidemic outbreaks of ET-NANBH.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reyes, G R -- Purdy, M A -- Kim, J P -- Luk, K C -- Young, L M -- Fry, K E -- Bradley, D W -- New York, N.Y. -- Science. 1990 Mar 16;247(4948):1335-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Virology Department, Genelabs Incorporated, Redwood City, CA 94063.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2107574" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; DNA/genetics ; Hepatitis E/*microbiology ; Hepatitis Viruses/*genetics ; Hepatitis, Viral, Human/*microbiology ; Humans ; Macaca fascicularis ; Molecular Sequence Data ; Polymerase Chain Reaction ; RNA Viruses/genetics ; RNA, Viral/genetics ; Restriction Mapping
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-02
    Description: Members of the gammaretroviruses--such as murine leukemia viruses (MLVs), most notably XMRV [xenotropic murine leukemia virus (X-MLV)-related virus--have been reported to be present in the blood of patients with chronic fatigue syndrome (CFS). We evaluated blood samples from 61 patients with CFS from a single clinical practice, 43 of whom had previously been identified as XMRV-positive. Our analysis included polymerase chain reaction and reverse transcription polymerase chain reaction procedures for detection of viral nucleic acids and assays for detection of infectious virus and virus-specific antibodies. We found no evidence of XMRV or other MLVs in these blood samples. In addition, we found that these gammaretroviruses were strongly (X-MLV) or partially (XMRV) susceptible to inactivation by sera from CFS patients and healthy controls, which suggested that establishment of a successful MLV infection in humans would be unlikely. Consistent with previous reports, we detected MLV sequences in commercial laboratory reagents. Our results indicate that previous evidence linking XMRV and MLVs to CFS is likely attributable to laboratory contamination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knox, Konstance -- Carrigan, Donald -- Simmons, Graham -- Teque, Fernando -- Zhou, Yanchen -- Hackett, John Jr -- Qiu, Xiaoxing -- Luk, Ka-Cheung -- Schochetman, Gerald -- Knox, Allyn -- Kogelnik, Andreas M -- Levy, Jay A -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):94-7. doi: 10.1126/science.1204963. Epub 2011 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wisconsin Viral Research Group, Milwaukee, WI 53226, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21628393" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Base Sequence ; Blood/*virology ; Child ; Child, Preschool ; Complement System Proteins/immunology ; DNA Contamination ; DNA, Viral/blood ; Drug Contamination ; Fatigue Syndrome, Chronic/blood/immunology/*virology ; Female ; Humans ; Indicators and Reagents ; Leukemia Virus, Murine/genetics/isolation & purification ; Leukocytes, Mononuclear/*virology ; Male ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Retroviridae Infections/diagnosis/*virology ; Xenotropic murine leukemia virus-related virus/genetics/immunology/*isolation & ; purification ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-03-19
    Description: Quantitative competitive polymerase chain reaction (QC-PCR) methods were used to quantify virion-associated human immunodeficiency virus type-1 (HIV-1) RNA in plasma from 66 patients with Centers for Disease Control stage I to IVC1 infection. HIV-1 RNA, ranging from 100 to nearly 22,000,000 copies per milliliter of plasma (corresponding to 50 to 11,000,000 virions per milliliter), was readily quantified in all subjects, was significantly associated with disease stage and CD4+ T cell counts, and decreased by as much as 235-fold with resolution of primary infection or institution of antiretroviral therapy. Plasma virus levels determined by QC-PCR correlated with, but exceeded by an average of 60,000-fold, virus titers measured by endpoint dilution culture. Quantitation of HIV-1 in plasma by QC-PCR may be useful in assessing the efficacy of antiretroviral agents, especially in early stage disease when conventional viral markers are often negative.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piatak, M Jr -- Saag, M S -- Yang, L C -- Clark, S J -- Kappes, J C -- Luk, K C -- Hahn, B H -- Shaw, G M -- Lifson, J D -- AI25922/AI/NIAID NIH HHS/ -- AI27290/AI/NIAID NIH HHS/ -- AI32775/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Mar 19;259(5102):1749-54.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of HIV and Exploratory Research, Genelabs Technologies Inc., Redwood City, CA 94063.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8096089" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/blood/drug therapy/*microbiology ; CD4-Positive T-Lymphocytes/pathology ; HIV-1/genetics/*isolation & purification/physiology ; Humans ; Leukocyte Count ; *Polymerase Chain Reaction ; RNA, Viral/*blood ; Ultracentrifugation ; Virus Replication ; Zidovudine/therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Unknown
    Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: Parkinson's disease is characterized by abundant alpha-synuclein (alpha-Syn) neuronal inclusions, known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine neurons. However, a cause-and-effect relationship between Lewy inclusion formation and neurodegeneration remains unclear. Here, we found that in wild-type nontransgenic mice, a single intrastriatal inoculation of synthetic alpha-Syn fibrils led to the cell-to-cell transmission of pathologic alpha-Syn and Parkinson's-like Lewy pathology in anatomically interconnected regions. Lewy pathology accumulation resulted in progressive loss of dopamine neurons in the substantia nigra pars compacta, but not in the adjacent ventral tegmental area, and was accompanied by reduced dopamine levels culminating in motor deficits. This recapitulation of a neurodegenerative cascade thus establishes a mechanistic link between transmission of pathologic alpha-Syn and the cardinal features of Parkinson's disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552321/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552321/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luk, Kelvin C -- Kehm, Victoria -- Carroll, Jenna -- Zhang, Bin -- O'Brien, Patrick -- Trojanowski, John Q -- Lee, Virginia M-Y -- NS053488/NS/NINDS NIH HHS/ -- P50 NS053488/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):949-53. doi: 10.1126/science.1227157.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4283, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Corpus Striatum/drug effects/*metabolism/pathology ; Dopamine ; Dopaminergic Neurons/drug effects/metabolism/pathology ; Injections ; Lewy Bodies/drug effects/*metabolism/pathology ; Mice ; Parkinsonian Disorders/*metabolism/pathology ; Protein Folding ; Protein Transport ; Recombinant Proteins/administration & dosage/chemistry/metabolism ; Substantia Nigra/drug effects/metabolism/pathology ; alpha-Synuclein/administration & dosage/chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Electronic Resource
    Electronic Resource
    The separation of phage promoter from bacterial lac promoter for β-galactosidase expression in transducing phage λplac5
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 89 (1979), S. 64-70 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(79)90943-4
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  • 6
    Electronic Resource
    Electronic Resource
    (2,3)-(α-methylenepenams: Synthesis and in vitro activity
    Amsterdam : Elsevier
    Bioorganic and Medicinal Chemistry 1 (1993), S. 173-182 
    Details
    ISSN: 0968-0896
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0968-0896(00)82118-5
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  • 7
    Electronic Resource
    Electronic Resource
    2-acetamido-2-deoxy-3,6:4,5-di-O-isopropylidene-d-glucose diethyl dithio-acetal and its single-crystal X-ray analysis.
    Amsterdam : Elsevier
    Carbohydrate Research 152 (1986), S. 274-278 
    Details
    ISSN: 0008-6215
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)90307-0
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  • 8
    Electronic Resource
    Electronic Resource
    A cluster of leftward rho-dependent t'"J terminators in the J gene of coliphage lambda
    Amsterdam : Elsevier
    Gene 21 (1983), S. 175-191 
    Details
    ISSN: 0378-1119
    Keywords: Molecular cloning ; N-antitermination ; S1 mapping ; galactokinase ; in vitro transcription
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(83)90001-X
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  • 9
    Electronic Resource
    Electronic Resource
    Characterization of the cloned terminators t"R"1, t"L"3 and t"I and the nut R antitermination site of coliphage lambda
    Amsterdam : Elsevier
    Gene 20 (1982), S. 127-134 
    Details
    ISSN: 0378-1119
    Keywords: N-unresponsive Tn10 termination ; Recombinant DNA ; gal operon ; galactokinase assay ; rho factor ; stimulatory effect of gene N product
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(82)90030-0
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  • 10
    Electronic Resource
    Electronic Resource
    Cloning and characterization of the termination site t"I for the gene int transcript in phage lambda
    Amsterdam : Elsevier
    Gene 17 (1982), S. 259-262 
    Details
    ISSN: 0378-1119
    Keywords: Molecular cloning ; galactokinase ; in vitro transcription ; recombinant DNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(82)90141-X
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