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  • Articles  (101)
  • Time Factors  (99)
  • Physics
  • 2015-2019  (101)
  • 2015  (101)
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  • 2015-2019  (101)
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  • 1
    Publication Date: 2015-04-23
    Description: The current outbreak of Ebola virus in West Africa is unprecedented, causing more cases and fatalities than all previous outbreaks combined, and has yet to be controlled. Several post-exposure interventions have been employed under compassionate use to treat patients repatriated to Europe and the United States. However, the in vivo efficacy of these interventions against the new outbreak strain of Ebola virus is unknown. Here we show that lipid-nanoparticle-encapsulated short interfering RNAs (siRNAs) rapidly adapted to target the Makona outbreak strain of Ebola virus are able to protect 100% of rhesus monkeys against lethal challenge when treatment was initiated at 3 days after exposure while animals were viraemic and clinically ill. Although all infected animals showed evidence of advanced disease including abnormal haematology, blood chemistry and coagulopathy, siRNA-treated animals had milder clinical features and fully recovered, while the untreated control animals succumbed to the disease. These results represent the first, to our knowledge, successful demonstration of therapeutic anti-Ebola virus efficacy against the new outbreak strain in nonhuman primates and highlight the rapid development of lipid-nanoparticle-delivered siRNA as a countermeasure against this highly lethal human disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467030/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467030/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thi, Emily P -- Mire, Chad E -- Lee, Amy C H -- Geisbert, Joan B -- Zhou, Joy Z -- Agans, Krystle N -- Snead, Nicholas M -- Deer, Daniel J -- Barnard, Trisha R -- Fenton, Karla A -- MacLachlan, Ian -- Geisbert, Thomas W -- U19 AI109711/AI/NIAID NIH HHS/ -- U19AI109711/AI/NIAID NIH HHS/ -- England -- Nature. 2015 May 21;521(7552):362-5. doi: 10.1038/nature14442. Epub 2015 Apr 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tekmira Pharmaceuticals, Burnaby, British Columbia V5J 5J8, Canada. ; 1] Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas 77550, USA [2] Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25901685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Disease Models, Animal ; Ebolavirus/classification/*drug effects/*genetics ; Female ; Hemorrhagic Fever, Ebola/pathology/prevention & control/*therapy/*virology ; Humans ; Macaca mulatta/virology ; Male ; Nanoparticles/*administration & dosage ; RNA, Small Interfering/*administration & dosage/pharmacology/*therapeutic use ; Survival Analysis ; Time Factors ; Treatment Outcome ; Viral Load/drug effects
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2015-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geddes, Linda -- England -- Nature. 2015 Nov 5;527(7576):22-5. doi: 10.1038/527022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26536940" target="_blank"〉PubMed〈/a〉
    Keywords: Attention Deficit Disorder with ; Hyperactivity/diagnosis/physiopathology/psychology ; Autism Spectrum Disorder/diagnosis/physiopathology/psychology ; Brain/blood supply/*growth & development/*physiology ; *Child Development ; Child, Preschool ; Electroencephalography ; Electromyography ; Eye Movements/physiology ; Female ; Humans ; Infant ; Infant Behavior/*physiology/*psychology ; *Laboratories ; London ; Magnetic Resonance Imaging ; Male ; Mirror Neurons ; Neuroimaging ; Personality ; Spectroscopy, Near-Infrared ; Time Factors
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2015-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 May 28;521(7553):394. doi: 10.1038/521394a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26017406" target="_blank"〉PubMed〈/a〉
    Keywords: *Bibliometrics/history ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Research/*history ; Time Factors
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  • 4
    Publication Date: 2015-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Oliveira, Joao Ricardo Mendes -- England -- Nature. 2015 Oct 22;526(7574):506. doi: 10.1038/526506e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Federal University of Pernambuco, Recife, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26490608" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil ; Financing, Organized/*economics/*organization & administration ; Research Personnel/*economics ; Research Support as Topic/*economics/*organization & administration ; Time Factors
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  • 5
    Publication Date: 2015-05-29
    Description: Robots have transformed many industries, most notably manufacturing, and have the power to deliver tremendous benefits to society, such as in search and rescue, disaster response, health care and transportation. They are also invaluable tools for scientific exploration in environments inaccessible to humans, from distant planets to deep oceans. A major obstacle to their widespread adoption in more complex environments outside factories is their fragility. Whereas animals can quickly adapt to injuries, current robots cannot 'think outside the box' to find a compensatory behaviour when they are damaged: they are limited to their pre-specified self-sensing abilities, can diagnose only anticipated failure modes, and require a pre-programmed contingency plan for every type of potential damage, an impracticality for complex robots. A promising approach to reducing robot fragility involves having robots learn appropriate behaviours in response to damage, but current techniques are slow even with small, constrained search spaces. Here we introduce an intelligent trial-and-error algorithm that allows robots to adapt to damage in less than two minutes in large search spaces without requiring self-diagnosis or pre-specified contingency plans. Before the robot is deployed, it uses a novel technique to create a detailed map of the space of high-performing behaviours. This map represents the robot's prior knowledge about what behaviours it can perform and their value. When the robot is damaged, it uses this prior knowledge to guide a trial-and-error learning algorithm that conducts intelligent experiments to rapidly discover a behaviour that compensates for the damage. Experiments reveal successful adaptations for a legged robot injured in five different ways, including damaged, broken, and missing legs, and for a robotic arm with joints broken in 14 different ways. This new algorithm will enable more robust, effective, autonomous robots, and may shed light on the principles that animals use to adapt to injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cully, Antoine -- Clune, Jeff -- Tarapore, Danesh -- Mouret, Jean-Baptiste -- England -- Nature. 2015 May 28;521(7553):503-7. doi: 10.1038/nature14422.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Sorbonne Universites, Universite Pierre et Marie Curie (UPMC), Paris 06, UMR 7222, Institut des Systemes Intelligents et de Robotique (ISIR), F-75005, Paris, France [2] CNRS, UMR 7222, Institut des Systemes Intelligents et de Robotique (ISIR), F-75005, Paris, France. ; Department of Computer Science, University of Wyoming, Laramie, Wyoming 82071, USA. ; 1] Sorbonne Universites, Universite Pierre et Marie Curie (UPMC), Paris 06, UMR 7222, Institut des Systemes Intelligents et de Robotique (ISIR), F-75005, Paris, France [2] CNRS, UMR 7222, Institut des Systemes Intelligents et de Robotique (ISIR), F-75005, Paris, France [3] Inria, Team Larsen, Villers-les-Nancy, F-54600, France [4] CNRS, Loria, UMR 7503, Vandoeuvre-les-Nancy, F-54500, France [5] Universite de Lorraine, Loria, UMR 7503, Vandoeuvre-les-Nancy, F-54500, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26017452" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Algorithms ; Animals ; *Artificial Intelligence ; Behavior, Animal ; Biomimetics/*methods ; Dogs ; Extremities/*injuries/physiopathology ; Motor Skills ; Robotics/*instrumentation/*methods ; Time Factors
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  • 6
    Publication Date: 2015-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tollefson, Jeff -- England -- Nature. 2015 Sep 24;525(7570):434-5. doi: 10.1038/525434a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26399805" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/legislation & jurisprudence/*trends ; *Goals ; Humans ; *International Cooperation ; Poverty/legislation & jurisprudence/*prevention & control/trends ; Time Factors ; *United Nations/legislation & jurisprudence
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  • 7
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    Nature Publishing Group (NPG)
    Publication Date: 2015-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Dan -- England -- Nature. 2015 Mar 12;519(7542):148-50. doi: 10.1038/519148a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762265" target="_blank"〉PubMed〈/a〉
    Keywords: *Computer Simulation ; *Conflict (Psychology) ; Feedback ; Humans ; Mathematics ; *Models, Theoretical ; Negotiating/psychology ; Psychology, Social/*methods ; *Research ; Time Factors ; Violence/prevention & control ; *Warfare
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  • 8
    Publication Date: 2015-04-10
    Description: Continuing degradation of coral reef ecosystems has generated substantial interest in how management can support reef resilience. Fishing is the primary source of diminished reef function globally, leading to widespread calls for additional marine reserves to recover fish biomass and restore key ecosystem functions. Yet there are no established baselines for determining when these conservation objectives have been met or whether alternative management strategies provide similar ecosystem benefits. Here we establish empirical conservation benchmarks and fish biomass recovery timelines against which coral reefs can be assessed and managed by studying the recovery potential of more than 800 coral reefs along an exploitation gradient. We show that resident reef fish biomass in the absence of fishing (B0) averages approximately 1,000 kg ha(-1), and that the vast majority (83%) of fished reefs are missing more than half their expected biomass, with severe consequences for key ecosystem functions such as predation. Given protection from fishing, reef fish biomass has the potential to recover within 35 years on average and less than 60 years when heavily depleted. Notably, alternative fisheries restrictions are largely (64%) successful at maintaining biomass above 50% of B0, sustaining key functions such as herbivory. Our results demonstrate that crucial ecosystem functions can be maintained through a range of fisheries restrictions, allowing coral reef managers to develop recovery plans that meet conservation and livelihood objectives in areas where marine reserves are not socially or politically feasible solutions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacNeil, M Aaron -- Graham, Nicholas A J -- Cinner, Joshua E -- Wilson, Shaun K -- Williams, Ivor D -- Maina, Joseph -- Newman, Steven -- Friedlander, Alan M -- Jupiter, Stacy -- Polunin, Nicholas V C -- McClanahan, Tim R -- England -- Nature. 2015 Apr 16;520(7547):341-4. doi: 10.1038/nature14358. Epub 2015 Apr 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Australian Institute of Marine Science, PMB 3 Townsville MC, Townsville, Queensland 4810, Australia [2] Department of Mathematics and Statistics, Dalhousie University, Halifax, Nova Scotia B3H 3J5, Canada [3] Australian Research Council Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland 4811, Australia. ; Australian Research Council Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland 4811, Australia. ; 1] Department of Parks and Wildlife, Kensington, Perth, Western Australia 6151, Australia [2] Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia. ; Coral Reef Ecosystems Division, NOAA Pacific Islands Fisheries Science Center, Honolulu, Hawaii 96818, USA. ; 1] Australian Research Council Centre of Excellence for Environmental Decisions (CEED), University of Queensland, Brisbane, St Lucia, Queensland 4074, Australia [2] Wildlife Conservation Society, Marine Programs, Bronx, New York 10460, USA. ; School of Marine Science and Technology, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. ; 1] Fisheries Ecology Research Lab, Department of Biology, University of Hawaii, Honolulu, Hawaii 96822, USA [2] Pristine Seas-National Geographic, Washington DC 20036, USA. ; Wildlife Conservation Society, Marine Programs, Bronx, New York 10460, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25855298" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Biomass ; Conservation of Natural Resources/*methods/statistics & numerical data/*trends ; *Coral Reefs ; *Ecosystem ; Fisheries/*methods/standards/*statistics & numerical data ; Fishes/*physiology ; Herbivory ; Population Dynamics ; Predatory Behavior ; Time Factors
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  • 9
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    Nature Publishing Group (NPG)
    Publication Date: 2015-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, Zhaohui -- England -- Nature. 2015 Jan 8;517(7533):145. doi: 10.1038/517145c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ningbo University School of Medicine, Ningbo, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25567273" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/adverse effects/*prevention & control ; China ; Climate Change ; Congresses as Topic ; Humans ; Public Health ; Time Factors
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  • 10
    Publication Date: 2015-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Hong -- Thompson, Julian R -- Flower, Roger J -- England -- Nature. 2015 Sep 24;525(7570):455. doi: 10.1038/525455e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Oslo, Norway. ; University College London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26399818" target="_blank"〉PubMed〈/a〉
    Keywords: China ; Electric Power Supplies/utilization ; Rain ; *Seasons ; Snow ; *Snow Sports/economics ; Time Factors ; Water Supply/economics/*statistics & numerical data
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  • 11
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    Nature Publishing Group (NPG)
    Publication Date: 2015-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gould, Julie -- England -- Nature. 2015 Dec 3;528(7580):22-5. doi: 10.1038/528022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26632571" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/education/manpower ; Career Choice ; *Career Mobility ; Education, Graduate/methods/*statistics & numerical data/*trends ; Employment/*statistics & numerical data ; Engineering/education/manpower ; Research Personnel/*education/*statistics & numerical data ; Time Factors
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  • 12
    Publication Date: 2015-10-28
    Description: Growing evidence demonstrates that climatic conditions can have a profound impact on the functioning of modern human societies, but effects on economic activity appear inconsistent. Fundamental productive elements of modern economies, such as workers and crops, exhibit highly non-linear responses to local temperature even in wealthy countries. In contrast, aggregate macroeconomic productivity of entire wealthy countries is reported not to respond to temperature, while poor countries respond only linearly. Resolving this conflict between micro and macro observations is critical to understanding the role of wealth in coupled human-natural systems and to anticipating the global impact of climate change. Here we unify these seemingly contradictory results by accounting for non-linearity at the macro scale. We show that overall economic productivity is non-linear in temperature for all countries, with productivity peaking at an annual average temperature of 13 degrees C and declining strongly at higher temperatures. The relationship is globally generalizable, unchanged since 1960, and apparent for agricultural and non-agricultural activity in both rich and poor countries. These results provide the first evidence that economic activity in all regions is coupled to the global climate and establish a new empirical foundation for modelling economic loss in response to climate change, with important implications. If future adaptation mimics past adaptation, unmitigated warming is expected to reshape the global economy by reducing average global incomes roughly 23% by 2100 and widening global income inequality, relative to scenarios without climate change. In contrast to prior estimates, expected global losses are approximately linear in global mean temperature, with median losses many times larger than leading models indicate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burke, Marshall -- Hsiang, Solomon M -- Miguel, Edward -- England -- Nature. 2015 Nov 12;527(7577):235-9. doi: 10.1038/nature15725. Epub 2015 Oct 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth System Science, Stanford University, California 94305, USA. ; Center on Food Security and the Environment, Stanford University, California 94305, USA. ; Goldman School of Public Policy, University of California, Berkeley, California 94720, USA. ; National Bureau of Economic Research. ; Department of Economics, University of California, Berkeley, California, 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26503051" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/economics/statistics & numerical data ; *Climate ; Developed Countries/economics ; Developing Countries/economics ; Efficiency ; Global Warming/*economics ; Income/statistics & numerical data/trends ; *Internationality ; *Models, Economic ; *Nonlinear Dynamics ; *Temperature ; Time Factors
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  • 13
    Publication Date: 2015-04-02
    Description: The cave infills at Sterkfontein contain one of the richest assemblages of Australopithecus fossils in the world, including the nearly complete skeleton StW 573 ('Little Foot') in its lower section, as well as early stone tools in higher sections. However, the chronology of the site remains controversial owing to the complex history of cave infilling. Much of the existing chronology based on uranium-lead dating and palaeomagnetic stratigraphy has recently been called into question by the recognition that dated flowstones fill cavities formed within previously cemented breccias and therefore do not form a stratigraphic sequence. Earlier dating with cosmogenic nuclides suffered a high degree of uncertainty and has been questioned on grounds of sediment reworking. Here we use isochron burial dating with cosmogenic aluminium-26 and beryllium-10 to show that the breccia containing StW 573 did not undergo significant reworking, and that it was deposited 3.67 +/- 0.16 million years ago, far earlier than the 2.2 million year flowstones found within it. The skeleton is thus coeval with early Australopithecus afarensis in eastern Africa. We also date the earliest stone tools at Sterkfontein to 2.18 +/- 0.21 million years ago, placing them in the Oldowan at a time similar to that found elsewhere in South Africa at Swartkans and Wonderwerk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Granger, Darryl E -- Gibbon, Ryan J -- Kuman, Kathleen -- Clarke, Ronald J -- Bruxelles, Laurent -- Caffee, Marc W -- England -- Nature. 2015 Jun 4;522(7554):85-8. doi: 10.1038/nature14268. Epub 2015 Apr 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth, Atmospheric, and Planetary Sciences, Purdue University, West Lafayette, Indiana 47907, USA. ; Department of Anthropology, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, Canada. ; 1] Evolutionary Studies Institute, University of the Witwatersrand, WITS 2050, Johannesburg, South Africa [2] School of Geography, Archaeology and Environmental Studies, University of the Witwatersrand, WITS 2050, Johannesburg, South Africa. ; Evolutionary Studies Institute, University of the Witwatersrand, WITS 2050, Johannesburg, South Africa. ; 1] School of Geography, Archaeology and Environmental Studies, University of the Witwatersrand, WITS 2050, Johannesburg, South Africa [2] French National Institute for Preventive Archaeological Research (Inrap), 561 rue Etienne Lenoir, km delta, 30900 Nimes, France [3] University of Toulouse Jean Jaures, UMR 5608 du CNRS (TRACES), Maison de la Recherche, 5 Allees Antonio Matchado, F-31058 Toulouse, France. ; 1] Department of Earth, Atmospheric, and Planetary Sciences, Purdue University, West Lafayette, Indiana 47907, USA [2] Department of Physics and Astronomy, Purdue University, West Lafayette, Indiana 47907, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25830884" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Eastern ; Aluminum ; Animals ; Beryllium ; Burial ; *Fossils ; Geologic Sediments/analysis/chemistry ; *Hominidae/anatomy & histology/classification ; Paleontology/*methods ; Radioisotopes ; Radiometric Dating/*methods ; *Skeleton ; Skull/anatomy & histology ; South Africa ; Time Factors ; Tool Use Behavior
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  • 14
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    Nature Publishing Group (NPG)
    Publication Date: 2015-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2015 May 21;521(7552):269. doi: 10.1038/nature.2015.17560.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25993935" target="_blank"〉PubMed〈/a〉
    Keywords: Bangladesh ; Ethiopia ; Evaluation Studies as Topic ; Humans ; *International Cooperation ; Pilot Projects ; Poverty/*economics/*prevention & control/statistics & numerical data/trends ; Program Evaluation ; Random Allocation ; Time Factors
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  • 15
    Publication Date: 2015-01-30
    Description: Most present-generation climate models simulate an increase in global-mean surface temperature (GMST) since 1998, whereas observations suggest a warming hiatus. It is unclear to what extent this mismatch is caused by incorrect model forcing, by incorrect model response to forcing or by random factors. Here we analyse simulations and observations of GMST from 1900 to 2012, and show that the distribution of simulated 15-year trends shows no systematic bias against the observations. Using a multiple regression approach that is physically motivated by surface energy balance, we isolate the impact of radiative forcing, climate feedback and ocean heat uptake on GMST--with the regression residual interpreted as internal variability--and assess all possible 15- and 62-year trends. The differences between simulated and observed trends are dominated by random internal variability over the shorter timescale and by variations in the radiative forcings used to drive models over the longer timescale. For either trend length, spread in simulated climate feedback leaves no traceable imprint on GMST trends or, consequently, on the difference between simulations and observations. The claim that climate models systematically overestimate the response to radiative forcing from increasing greenhouse gas concentrations therefore seems to be unfounded.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marotzke, Jochem -- Forster, Piers M -- England -- Nature. 2015 Jan 29;517(7536):565-70. doi: 10.1038/nature14117.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Meteorology, Bundesstrasse 53, 20146 Hamburg, Germany. ; School of Earth and Environment, University of Leeds, Leeds LS2 9JT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25631444" target="_blank"〉PubMed〈/a〉
    Keywords: Bias (Epidemiology) ; *Feedback ; Global Warming/history/*statistics & numerical data ; History, 20th Century ; History, 21st Century ; *Models, Theoretical ; Multivariate Analysis ; Regression Analysis ; Reproducibility of Results ; *Temperature ; Time Factors
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  • 16
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    Nature Publishing Group (NPG)
    Publication Date: 2015-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Jan 1;517(7532):5. doi: 10.1038/517005a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25557694" target="_blank"〉PubMed〈/a〉
    Keywords: Natural Science Disciplines ; *Policy Making ; Social Sciences/*trends ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 17
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    Nature Publishing Group (NPG)
    Publication Date: 2015-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knight, Rob -- England -- Nature. 2015 Feb 26;518(7540):S5. doi: 10.1038/518S5a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Diego.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25715279" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computer Simulation ; Crowdsourcing ; Disease Models, Animal ; Germ-Free Life ; Humans ; Kwashiorkor/etiology/genetics/microbiology/therapy ; Mice ; Microbiota/genetics/*physiology ; Obesity/etiology/*microbiology/*therapy ; Sequence Analysis, DNA ; Thinness/microbiology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 18
    Publication Date: 2015-01-21
    Description: Appropriate responses to an imminent threat brace us for adversities. The ability to sense and predict threatening or stressful events is essential for such adaptive behaviour. In the mammalian brain, one putative stress sensor is the paraventricular nucleus of the thalamus (PVT), an area that is readily activated by both physical and psychological stressors. However, the role of the PVT in the establishment of adaptive behavioural responses remains unclear. Here we show in mice that the PVT regulates fear processing in the lateral division of the central amygdala (CeL), a structure that orchestrates fear learning and expression. Selective inactivation of CeL-projecting PVT neurons prevented fear conditioning, an effect that can be accounted for by an impairment in fear-conditioning-induced synaptic potentiation onto somatostatin-expressing (SOM(+)) CeL neurons, which has previously been shown to store fear memory. Consistently, we found that PVT neurons preferentially innervate SOM(+) neurons in the CeL, and stimulation of PVT afferents facilitated SOM(+) neuron activity and promoted intra-CeL inhibition, two processes that are critical for fear learning and expression. Notably, PVT modulation of SOM(+) CeL neurons was mediated by activation of the brain-derived neurotrophic factor (BDNF) receptor tropomysin-related kinase B (TrkB). As a result, selective deletion of either Bdnf in the PVT or Trkb in SOM(+) CeL neurons impaired fear conditioning, while infusion of BDNF into the CeL enhanced fear learning and elicited unconditioned fear responses. Our results demonstrate that the PVT-CeL pathway constitutes a novel circuit essential for both the establishment of fear memory and the expression of fear responses, and uncover mechanisms linking stress detection in PVT with the emergence of adaptive behaviour.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376633/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376633/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Penzo, Mario A -- Robert, Vincent -- Tucciarone, Jason -- De Bundel, Dimitri -- Wang, Minghui -- Van Aelst, Linda -- Darvas, Martin -- Parada, Luis F -- Palmiter, Richard D -- He, Miao -- Huang, Z Josh -- Li, Bo -- R01 MH082808/MH/NIMH NIH HHS/ -- R01 MH094705/MH/NIMH NIH HHS/ -- R01 MH101214/MH/NIMH NIH HHS/ -- R01 NS082266/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Mar 26;519(7544):455-9. doi: 10.1038/nature13978. Epub 2015 Jan 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. ; 1] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA [2] Ecole Normale Superieure de Cachan, 94230 Cachan, France. ; 1] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA [2] Medical Scientist Training Program &Program in Neuroscience, Stony Brook University, Stony Brook, New York 11790, USA. ; CNRS, UMR-5203, INSERM U661, Institut de Genomique Fonctionnelle, 34090 Montpellier, France. ; Department of Pathology, University of Washington, Seattle, Washington 98104, USA. ; Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ; Howard Hughes Medical Institute; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. ; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25600269" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Central Amygdaloid Nucleus/cytology/*physiology ; Conditioning (Psychology)/physiology ; Fear/*physiology/psychology ; Female ; Male ; Memory/physiology ; Mice ; Neural Pathways/cytology/*physiology ; Neuronal Plasticity ; Neurons/metabolism ; Receptor, trkB/metabolism ; Somatostatin/metabolism ; Thalamus/cytology/*physiology ; Time Factors
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  • 19
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    Nature Publishing Group (NPG)
    Publication Date: 2015-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marris, Emma -- England -- Nature. 2015 Apr 23;520(7548):415. doi: 10.1038/nature.2015.17263.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25903602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deer/*physiology ; *Ecology/methods/trends ; Great Lakes Region ; *Islands ; Population Dynamics ; *Predatory Behavior ; Research/*trends ; Time Factors ; Wolves/*physiology
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  • 20
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    Nature Publishing Group (NPG)
    Publication Date: 2015-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhou, Yingying -- England -- Nature. 2015 Dec 17;528(7582):S170-3. doi: 10.1038/528S170a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26673023" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines ; Chemistry ; China ; Diffusion of Innovation ; Ecology ; Economic Recession ; Humans ; International Cooperation ; Nobel Prize ; Physics ; Research/economics/manpower/standards/*statistics & numerical data ; Research Personnel/education/standards/supply & distribution ; Time Factors
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  • 21
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    Nature Publishing Group (NPG)
    Publication Date: 2015-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dolgin, Elie -- England -- Nature. 2015 Mar 19;519(7543):276-8. doi: 10.1038/519276a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25788077" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Darkness ; Humans ; *Lighting ; Myopia/*epidemiology/*etiology/prevention & control ; *Sunlight ; Time Factors
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  • 22
    Publication Date: 2015-01-21
    Description: Fear memories allow animals to avoid danger, thereby increasing their chances of survival. Fear memories can be retrieved long after learning, but little is known about how retrieval circuits change with time. Here we show that the dorsal midline thalamus of rats is required for the retrieval of auditory conditioned fear at late (24 hours, 7 days, 28 days), but not early (0.5 hours, 6 hours) time points after learning. Consistent with this, the paraventricular nucleus of the thalamus (PVT), a subregion of the dorsal midline thalamus, showed increased c-Fos expression only at late time points, indicating that the PVT is gradually recruited for fear retrieval. Accordingly, the conditioned tone responses of PVT neurons increased with time after training. The prelimbic (PL) prefrontal cortex, which is necessary for fear retrieval, sends dense projections to the PVT. Retrieval at late time points activated PL neurons projecting to the PVT, and optogenetic silencing of these projections impaired retrieval at late, but not early, time points. In contrast, silencing of PL inputs to the basolateral amygdala impaired retrieval at early, but not late, time points, indicating a time-dependent shift in retrieval circuits. Retrieval at late time points also activated PVT neurons projecting to the central nucleus of the amygdala, and silencing these projections at late, but not early, time points induced a persistent attenuation of fear. Thus, the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term fear memories.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376623/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376623/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Do-Monte, Fabricio H -- Quinones-Laracuente, Kelvin -- Quirk, Gregory J -- G12 MD007600/MD/NIMHD NIH HHS/ -- K99 MH105549/MH/NIMH NIH HHS/ -- P50 MH086400/MH/NIMH NIH HHS/ -- P50-MH086400/MH/NIMH NIH HHS/ -- R01-MH058883/MH/NIMH NIH HHS/ -- R25 GM061838/GM/NIGMS NIH HHS/ -- R25-GM061838/GM/NIGMS NIH HHS/ -- R37 MH058883/MH/NIMH NIH HHS/ -- England -- Nature. 2015 Mar 26;519(7544):460-3. doi: 10.1038/nature14030. Epub 2015 Jan 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Psychiatry, University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico [2] Department of Anatomy &Neurobiology, University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25600268" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/physiology ; Animals ; Conditioning (Psychology)/physiology ; Fear/*physiology ; Male ; Memory/*physiology ; Neural Pathways/cytology/*physiology ; Neurons/physiology ; Optogenetics ; Prefrontal Cortex/cytology/physiology ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Sprague-Dawley ; Thalamus/cytology/physiology ; Time Factors
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  • 23
    Publication Date: 2015-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Victor, David G -- England -- Nature. 2015 Apr 2;520(7545):27-9. doi: 10.1038/520027a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory on International Law and Regulation, University of California, San Diego, USA. He is also chairman of the Global Agenda Council on Governance for Sustainability at the World Economic Forum.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25832390" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees/*organization & administration ; *Climate Change/statistics & numerical data ; Consensus ; Environmental Policy/legislation & jurisprudence/*trends ; *Policy Making ; Reproducibility of Results ; *Research Report ; Social Sciences/*trends ; Time Factors ; Uncertainty
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  • 24
    Publication Date: 2015-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Victor, David G -- Leape, James P -- England -- Nature. 2015 Nov 26;527(7579):439-41. doi: 10.1038/527439a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26607527" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil ; Carbon Dioxide/analysis/isolation & purification ; *Congresses as Topic ; Conservation of Natural Resources/economics/legislation & jurisprudence/trends ; Developing Countries/economics ; Diplomacy ; Environmental Policy/economics/legislation & jurisprudence/*trends ; Forestry/economics/legislation & jurisprudence/trends ; Global Warming/economics/legislation & jurisprudence/*prevention & control ; Goals ; International Cooperation/*legislation & jurisprudence ; Methane/analysis ; Negotiating ; Optimism ; Paris ; Temperature ; Time Factors ; United Nations/legislation & jurisprudence
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  • 25
    Publication Date: 2015-02-06
    Description: Theory and climate modelling suggest that the sensitivity of Earth's climate to changes in radiative forcing could depend on the background climate. However, palaeoclimate data have thus far been insufficient to provide a conclusive test of this prediction. Here we present atmospheric carbon dioxide (CO2) reconstructions based on multi-site boron-isotope records from the late Pliocene epoch (3.3 to 2.3 million years ago). We find that Earth's climate sensitivity to CO2-based radiative forcing (Earth system sensitivity) was half as strong during the warm Pliocene as during the cold late Pleistocene epoch (0.8 to 0.01 million years ago). We attribute this difference to the radiative impacts of continental ice-volume changes (the ice-albedo feedback) during the late Pleistocene, because equilibrium climate sensitivity is identical for the two intervals when we account for such impacts using sea-level reconstructions. We conclude that, on a global scale, no unexpected climate feedbacks operated during the warm Pliocene, and that predictions of equilibrium climate sensitivity (excluding long-term ice-albedo feedbacks) for our Pliocene-like future (with CO2 levels up to maximum Pliocene levels of 450 parts per million) are well described by the currently accepted range of an increase of 1.5 K to 4.5 K per doubling of CO2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez-Boti, M A -- Foster, G L -- Chalk, T B -- Rohling, E J -- Sexton, P F -- Lunt, D J -- Pancost, R D -- Badger, M P S -- Schmidt, D N -- England -- Nature. 2015 Feb 5;518(7537):49-54. doi: 10.1038/nature14145.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ocean and Earth Science, University of Southampton, National Oceanography Centre Southampton, Southampton, SO14 3ZH, UK. ; 1] Ocean and Earth Science, University of Southampton, National Oceanography Centre Southampton, Southampton, SO14 3ZH, UK [2] Research School of Earth Sciences, The Australian National University, Canberra, Australian Capital Territory 2601, Australia. ; Centre for Earth, Planetary, Space and Astronomical Research, The Open University, Milton Keynes, MK7 6AA, UK. ; 1] School of Geographical Sciences, University of Bristol, University Road, Bristol, BS8 1SS, UK [2] The Cabot Institute, University of Bristol, Bristol BS8 1UJ, UK. ; 1] The Cabot Institute, University of Bristol, Bristol BS8 1UJ, UK [2] Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK. ; 1] The Cabot Institute, University of Bristol, Bristol BS8 1UJ, UK [2] School of Earth Sciences, University of Bristol, Wills Memorial Building, Bristol, BS8 1RJ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25652996" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; Boron/analysis/chemistry ; Carbon Dioxide/*analysis ; *Climate ; *Feedback ; Foraminifera/metabolism ; Geologic Sediments/chemistry ; History, Ancient ; Hydrogen-Ion Concentration ; Ice Cover ; Oceans and Seas ; Oxygen Isotopes ; Temperature ; Time Factors
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  • 26
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    Nature Publishing Group (NPG)
    Publication Date: 2015-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perkel, Jeffrey M -- England -- Nature. 2015 Apr 2;520(7545):119-20. doi: 10.1038/520119a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25832406" target="_blank"〉PubMed〈/a〉
    Keywords: *Consumer Behavior ; *Internet/utilization ; Periodicals as Topic/economics/*standards ; Publishing/economics/*standards ; *Research Personnel/psychology ; Time Factors
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  • 27
    Publication Date: 2015-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zuidema, Pieter A -- Frank, David -- England -- Nature. 2015 Jul 30;523(7562):531. doi: 10.1038/523531c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wageningen University, the Netherlands. ; Swiss Federal Research Institute WSL, Birmensdorf, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26223617" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; Carbon Dioxide/metabolism ; Climate Change/*statistics & numerical data ; Forests ; Global Warming/prevention & control/statistics & numerical data ; Time Factors ; Trees/*growth & development/*physiology ; Tropical Climate
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  • 28
    Publication Date: 2015-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Callaway, Ewen -- England -- Nature. 2015 Apr 30;520(7549):598-9. doi: 10.1038/520598a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25925455" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics ; Altitude ; Altitude Sickness/genetics ; Caves ; DNA, Mitochondrial/analysis/genetics ; *Fossils ; Geography ; History, Ancient ; Human Migration/*history ; Humans ; *Phylogeny ; *Skeleton ; Skull/chemistry ; South America ; Time Factors ; Uncertainty
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  • 29
    Publication Date: 2015-03-04
    Description: Polyploidy is observed across the tree of life, yet its influence on evolution remains incompletely understood. Polyploidy, usually whole-genome duplication, is proposed to alter the rate of evolutionary adaptation. This could occur through complex effects on the frequency or fitness of beneficial mutations. For example, in diverse cell types and organisms, immediately after a whole-genome duplication, newly formed polyploids missegregate chromosomes and undergo genetic instability. The instability following whole-genome duplications is thought to provide adaptive mutations in microorganisms and can promote tumorigenesis in mammalian cells. Polyploidy may also affect adaptation independently of beneficial mutations through ploidy-specific changes in cell physiology. Here we perform in vitro evolution experiments to test directly whether polyploidy can accelerate evolutionary adaptation. Compared with haploids and diploids, tetraploids undergo significantly faster adaptation. Mathematical modelling suggests that rapid adaptation of tetraploids is driven by higher rates of beneficial mutations with stronger fitness effects, which is supported by whole-genome sequencing and phenotypic analyses of evolved clones. Chromosome aneuploidy, concerted chromosome loss, and point mutations all provide large fitness gains. We identify several mutations whose beneficial effects are manifest specifically in the tetraploid strains. Together, these results provide direct quantitative evidence that in some environments polyploidy can accelerate evolutionary adaptation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497379/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497379/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selmecki, Anna M -- Maruvka, Yosef E -- Richmond, Phillip A -- Guillet, Marie -- Shoresh, Noam -- Sorenson, Amber L -- De, Subhajyoti -- Kishony, Roy -- Michor, Franziska -- Dowell, Robin -- Pellman, David -- R01 GM081617/GM/NIGMS NIH HHS/ -- R37 GM061345/GM/NIGMS NIH HHS/ -- R37 GM61345/GM/NIGMS NIH HHS/ -- U54CA143798/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Mar 19;519(7543):349-52. doi: 10.1038/nature14187. Epub 2015 Mar 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA [2] Department of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02215, USA [3] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA. ; 1] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue Boston, Massachusetts 02215, USA [2] Department of Biostatistics, Harvard School of Public Health, 158 Longwood Avenue, Boston, Massachusetts 02215, USA. ; 1] BioFrontiers Institute, University of Colorado at Boulder, 3415 Colorado Avenue, Boulder, Colorado 80303, USA [2] Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, 347 UCB, Boulder, Colorado 80309, USA. ; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA. ; 1] Department of Medicine, University of Colorado School of Medicine, 13001 East 17th Place, Aurora, Colorado 80045, USA [2] Department of Biostatistics and Informatics, Colorado School of Public Health, 13001 East 17th Place, Aurora, Colorado 80045, USA [3] Molecular Oncology Program, University of Colorado Cancer Center, 13001 East 17th Place, Aurora, Colorado 80045, USA. ; 1] Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, Massachusetts 02115, USA [2] Department of Biology, Technion - Israel Institute of Technology, Haifa, 32000, Israel. ; 1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA [2] Department of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02215, USA [3] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA [4] Department of Pediatric Hematology/Oncology, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25731168" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/*genetics ; Aneuploidy ; *Biological Evolution ; Chromosomes, Fungal/genetics ; Clone Cells/cytology/metabolism ; Diploidy ; Genetic Fitness/genetics ; Haploidy ; Mutation Rate ; Point Mutation/genetics ; *Polyploidy ; Saccharomyces cerevisiae/cytology/*genetics/metabolism/*physiology ; Time Factors
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  • 30
    Publication Date: 2015-03-25
    Description: Adult stem cells occur in niches that balance self-renewal with lineage selection and progression during tissue homeostasis. Following injury, culture or transplantation, stem cells outside their niche often display fate flexibility. Here we show that super-enhancers underlie the identity, lineage commitment and plasticity of adult stem cells in vivo. Using hair follicle as a model, we map the global chromatin domains of hair follicle stem cells and their committed progenitors in their native microenvironments. We show that super-enhancers and their dense clusters ('epicentres') of transcription factor binding sites undergo remodelling upon lineage progression. New fate is acquired by decommissioning old and establishing new super-enhancers and/or epicentres, an auto-regulatory process that abates one master regulator subset while enhancing another. We further show that when outside their niche, either in vitro or in wound-repair, hair follicle stem cells dynamically remodel super-enhancers in response to changes in their microenvironment. Intriguingly, some key super-enhancers shift epicentres, enabling their genes to remain active and maintain a transitional state in an ever-changing transcriptional landscape. Finally, we identify SOX9 as a crucial chromatin rheostat of hair follicle stem cell super-enhancers, and provide functional evidence that super-enhancers are dynamic, dense transcription-factor-binding platforms which are acutely sensitive to pioneer master regulators whose levels define not only spatial and temporal features of lineage-status but also stemness, plasticity in transitional states and differentiation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482136/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482136/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adam, Rene C -- Yang, Hanseul -- Rockowitz, Shira -- Larsen, Samantha B -- Nikolova, Maria -- Oristian, Daniel S -- Polak, Lisa -- Kadaja, Meelis -- Asare, Amma -- Zheng, Deyou -- Fuchs, Elaine -- R01 AR031737/AR/NIAMS NIH HHS/ -- R01-AR31737/AR/NIAMS NIH HHS/ -- R21 MH099452/MH/NIMH NIH HHS/ -- R21MH099452/MH/NIMH NIH HHS/ -- T32 GM066699/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 May 21;521(7552):366-70. doi: 10.1038/nature14289. Epub 2015 Mar 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology &Development, The Rockefeller University, New York, New York 10065, USA. ; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA. ; 1] Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA [2] Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25799994" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Adult Stem Cells/*cytology/metabolism ; Animals ; Base Sequence ; Cell Differentiation/*genetics ; Cell Lineage/*genetics ; Chromatin/genetics/metabolism ; Enhancer Elements, Genetic/*genetics ; Female ; Hair Follicle/*cytology ; Mice ; Organ Specificity ; SOX9 Transcription Factor/*metabolism ; Stem Cell Niche ; Time Factors
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  • 31
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    Nature Publishing Group (NPG)
    Publication Date: 2015-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Callaway, Ewen -- England -- Nature. 2015 Mar 12;519(7542):139-40. doi: 10.1038/519139a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762261" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Child ; Congresses as Topic ; DNA/*genetics ; Fossils ; Genome/*genetics ; Humans ; Mutagenesis/*genetics ; *Mutation Rate ; Primates/genetics ; Time Factors ; *Uncertainty
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  • 32
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    Nature Publishing Group (NPG)
    Publication Date: 2015-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Callaway, Ewen -- England -- Nature. 2015 Jan 29;517(7536):541. doi: 10.1038/517541a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25631427" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breeding/history ; Europe ; *Fossils ; History, Ancient ; Humans ; Israel ; *Neanderthals/genetics ; Skull/anatomy & histology ; Time Factors
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  • 33
    Publication Date: 2015-03-13
    Description: Stochastic processes in cells are associated with fluctuations in mRNA, protein production and degradation, noisy partition of cellular components at division, and other cell processes. Variability within a clonal population of cells originates from such stochastic processes, which may be amplified or reduced by deterministic factors. Cell-to-cell variability, such as that seen in the heterogeneous response of bacteria to antibiotics, or of cancer cells to treatment, is understood as the inevitable consequence of stochasticity. Variability in cell-cycle duration was observed long ago; however, its sources are still unknown. A central question is whether the variance of the observed distribution originates from stochastic processes, or whether it arises mostly from a deterministic process that only appears to be random. A surprising feature of cell-cycle-duration inheritance is that it seems to be lost within one generation but to be still present in the next generation, generating poor correlation between mother and daughter cells but high correlation between cousin cells. This observation suggests the existence of underlying deterministic factors that determine the main part of cell-to-cell variability. We developed an experimental system that precisely measures the cell-cycle duration of thousands of mammalian cells along several generations and a mathematical framework that allows discrimination between stochastic and deterministic processes in lineages of cells. We show that the inter- and intra-generation correlations reveal complex inheritance of the cell-cycle duration. Finally, we build a deterministic nonlinear toy model for cell-cycle inheritance that reproduces the main features of our data. Our approach constitutes a general method to identify deterministic variability in lineages of cells or organisms, which may help to predict and, eventually, reduce cell-to-cell heterogeneity in various systems, such as cancer cells under treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sandler, Oded -- Mizrahi, Sivan Pearl -- Weiss, Noga -- Agam, Oded -- Simon, Itamar -- Balaban, Nathalie Q -- England -- Nature. 2015 Mar 26;519(7544):468-71. doi: 10.1038/nature14318. Epub 2015 Mar 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel. ; 1] Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel [2] Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel. ; Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762143" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/pharmacology ; Cell Cycle/drug effects/*genetics ; Cell Division/drug effects/genetics ; Cell Line ; *Cell Lineage ; Mammals ; Models, Biological ; Stochastic Processes ; Time Factors
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  • 34
    Publication Date: 2015-09-30
    Description: Earlier spring leaf unfolding is a frequently observed response of plants to climate warming. Many deciduous tree species require chilling for dormancy release, and warming-related reductions in chilling may counteract the advance of leaf unfolding in response to warming. Empirical evidence for this, however, is limited to saplings or twigs in climate-controlled chambers. Using long-term in situ observations of leaf unfolding for seven dominant European tree species at 1,245 sites, here we show that the apparent response of leaf unfolding to climate warming (ST, expressed in days advance of leaf unfolding per degrees C warming) has significantly decreased from 1980 to 2013 in all monitored tree species. Averaged across all species and sites, ST decreased by 40% from 4.0 +/- 1.8 days degrees C(-1) during 1980-1994 to 2.3 +/- 1.6 days degrees C(-1) during 1999-2013. The declining ST was also simulated by chilling-based phenology models, albeit with a weaker decline (24-30%) than observed in situ. The reduction in ST is likely to be partly attributable to reduced chilling. Nonetheless, other mechanisms may also have a role, such as 'photoperiod limitation' mechanisms that may become ultimately limiting when leaf unfolding dates occur too early in the season. Our results provide empirical evidence for a declining ST, but also suggest that the predicted strong winter warming in the future may further reduce ST and therefore result in a slowdown in the advance of tree spring phenology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fu, Yongshuo H -- Zhao, Hongfang -- Piao, Shilong -- Peaucelle, Marc -- Peng, Shushi -- Zhou, Guiyun -- Ciais, Philippe -- Huang, Mengtian -- Menzel, Annette -- Penuelas, Josep -- Song, Yang -- Vitasse, Yann -- Zeng, Zhenzhong -- Janssens, Ivan A -- England -- Nature. 2015 Oct 1;526(7571):104-7. doi: 10.1038/nature15402. Epub 2015 Sep 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sino-French Institute for Earth System Science, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. ; Centre of Excellence PLECO (Plant and Vegetation Ecology), Department of Biology, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. ; Key Laboratory of Alpine Ecology and Biodiversity, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China. ; Center for Excellence in Tibetan Earth Science, Chinese Academy of Sciences, Beijing 100085, China. ; Laboratoire des Sciences du Climat et de l'Environnement, CEA CNRS UVSQ, Gif-sur-Yvette 91190, France. ; School of Resources and Environment, University of Electronic Science and Technology of China, Chengdu 611731, China. ; Ecoclimatology, Technische Universitat Munchen, Freising 85354, Germany. ; Technische Universitat Munchen, Institute for Advanced Study, Lichtenbergstrasse 2a, 85748 Garching, Germany. ; CREAF, Cerdanyola del Valles, Barcelona 08193, Catalonia, Spain. ; CSIC, Global Ecology Unit CREAF-CSIC-UAB, Cerdanyola del Valles, Barcelona 08193, Catalonia, Spain. ; Department of Atmospheric Sciences, University of Illinois, Urbana, Illinois 61801, USA. ; University of Neuchatel, Institute of Geography, Neuchatel 2000, Switzerland. ; WSL Swiss Federal Institute for Forest, Snow and Landscape Research, Neuchatel 2000, Switzerland. ; WSL Institute for Snow and Avalanche Research SLF, Group Mountain Ecosystems, Davos 7260, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26416746" target="_blank"〉PubMed〈/a〉
    Keywords: Cold Temperature ; Europe ; *Global Warming ; Models, Biological ; Photoperiod ; Plant Leaves/*growth & development ; *Seasons ; Time Factors ; Trees/*growth & development
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  • 35
    Publication Date: 2015-06-23
    Description: The mammalian hippocampus is crucial for episodic memory formation and transiently retains information for about 3-4 weeks in adult mice and longer in humans. Although neuroscientists widely believe that neural synapses are elemental sites of information storage, there has been no direct evidence that hippocampal synapses persist for time intervals commensurate with the duration of hippocampal-dependent memory. Here we tested the prediction that the lifetimes of hippocampal synapses match the longevity of hippocampal memory. By using time-lapse two-photon microendoscopy in the CA1 hippocampal area of live mice, we monitored the turnover dynamics of the pyramidal neurons' basal dendritic spines, postsynaptic structures whose turnover dynamics are thought to reflect those of excitatory synaptic connections. Strikingly, CA1 spine turnover dynamics differed sharply from those seen previously in the neocortex. Mathematical modelling revealed that the data best matched kinetic models with a single population of spines with a mean lifetime of approximately 1-2 weeks. This implies approximately 100% turnover in approximately 2-3 times this interval, a near full erasure of the synaptic connectivity pattern. Although N-methyl-d-aspartate (NMDA) receptor blockade stabilizes spines in the neocortex, in CA1 it transiently increased the rate of spine loss and thus lowered spine density. These results reveal that adult neocortical and hippocampal pyramidal neurons have divergent patterns of spine regulation and quantitatively support the idea that the transience of hippocampal-dependent memory directly reflects the turnover dynamics of hippocampal synapses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648621/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648621/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attardo, Alessio -- Fitzgerald, James E -- Schnitzer, Mark J -- R21 AG038771/AG/NIA NIH HHS/ -- R21 MH092809/MH/NIMH NIH HHS/ -- England -- Nature. 2015 Jul 30;523(7562):592-6. doi: 10.1038/nature14467. Epub 2015 Jun 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] James H. Clark Center for Biomedical Engineering &Sciences, Stanford University, Stanford, California 94305, USA [2] Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA. ; James H. Clark Center for Biomedical Engineering &Sciences, Stanford University, Stanford, California 94305, USA. ; 1] James H. Clark Center for Biomedical Engineering &Sciences, Stanford University, Stanford, California 94305, USA [2] Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA [3] CNC Program, Stanford University, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26098371" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CA1 Region, Hippocampal/*cytology/*metabolism ; Dendritic Spines/*metabolism ; Endoscopy ; Kinetics ; Male ; Memory, Episodic ; Mice ; Neocortex/cytology/metabolism ; Neuronal Plasticity/*physiology ; Photons ; Pyramidal Cells/cytology/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism ; Time Factors
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  • 36
    Publication Date: 2015-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cesare, Chris -- England -- Nature. 2015 Jul 30;523(7562):513-4. doi: 10.1038/523513a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26223606" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence/trends ; National Institutes of Health (U.S.)/economics ; *Politics ; Science/*economics ; Time Factors ; United States ; United States Government Agencies/*economics ; United States National Aeronautics and Space Administration/economics
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  • 37
    Publication Date: 2015-06-19
    Description: Stress is considered a potent environmental risk factor for many behavioural abnormalities, including anxiety and mood disorders. Animal models can exhibit limited but quantifiable behavioural impairments resulting from chronic stress, including deficits in motivation, abnormal responses to behavioural challenges, and anhedonia. The hippocampus is thought to negatively regulate the stress response and to mediate various cognitive and mnemonic aspects of stress-induced impairments, although the neuronal underpinnings sufficient to support behavioural improvements are largely unknown. Here we acutely rescue stress-induced depression-related behaviours in mice by optogenetically reactivating dentate gyrus cells that were previously active during a positive experience. A brain-wide histological investigation, coupled with pharmacological and projection-specific optogenetic blockade experiments, identified glutamatergic activity in the hippocampus-amygdala-nucleus-accumbens pathway as a candidate circuit supporting the acute rescue. Finally, chronically reactivating hippocampal cells associated with a positive memory resulted in the rescue of stress-induced behavioural impairments and neurogenesis at time points beyond the light stimulation. Together, our data suggest that activating positive memories artificially is sufficient to suppress depression-like behaviours and point to dentate gyrus engram cells as potential therapeutic nodes for intervening with maladaptive behavioural states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramirez, Steve -- Liu, Xu -- MacDonald, Christopher J -- Moffa, Anthony -- Zhou, Joanne -- Redondo, Roger L -- Tonegawa, Susumu -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Jun 18;522(7556):335-9. doi: 10.1038/nature14514.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. ; 1] RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26085274" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/metabolism/physiology ; Animals ; Behavior, Animal ; Depression/*psychology/*therapy ; Female ; Hippocampus/cytology/physiology ; Male ; Memory/*physiology ; Mice ; Mice, Inbred C57BL ; Neural Pathways ; Nucleus Accumbens/cytology/metabolism/physiology ; Optogenetics ; Pleasure/*physiology ; Proto-Oncogene Proteins c-fos/metabolism ; Stress, Psychological/psychology ; Time Factors
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  • 38
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    Nature Publishing Group (NPG)
    Publication Date: 2015-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2015 May 28;521(7553):405-6. doi: 10.1038/521405a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26017422" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western/epidemiology ; Clinical Trials as Topic/*trends ; Disease Outbreaks/prevention & control ; Ebola Vaccines/*supply & distribution ; Hemorrhagic Fever, Ebola/epidemiology/*prevention & control/*therapy/virology ; Humans ; Time Factors ; World Health Organization/organization & administration
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  • 39
    Publication Date: 2015-03-31
    Description: The brain has an extraordinary capacity for memory storage, but how it stores new information without disrupting previously acquired memories remains unknown. Here we show that different motor learning tasks induce dendritic Ca(2+) spikes on different apical tuft branches of individual layer V pyramidal neurons in the mouse motor cortex. These task-related, branch-specific Ca(2+) spikes cause long-lasting potentiation of postsynaptic dendritic spines active at the time of spike generation. When somatostatin-expressing interneurons are inactivated, different motor tasks frequently induce Ca(2+) spikes on the same branches. On those branches, spines potentiated during one task are depotentiated when they are active seconds before Ca(2+) spikes induced by another task. Concomitantly, increased neuronal activity and performance improvement after learning one task are disrupted when another task is learned. These findings indicate that dendritic-branch-specific generation of Ca(2+) spikes is crucial for establishing long-lasting synaptic plasticity, thereby facilitating information storage associated with different learning experiences.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476301/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476301/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cichon, Joseph -- Gan, Wen-Biao -- P01 NS074972/NS/NINDS NIH HHS/ -- R01 NS047325/NS/NINDS NIH HHS/ -- England -- Nature. 2015 Apr 9;520(7546):180-5. doi: 10.1038/nature14251. Epub 2015 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25822789" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Calcium/*metabolism ; Calcium Signaling ; Dendrites/*metabolism ; Dendritic Spines/metabolism ; Female ; Interneurons/metabolism ; Long-Term Potentiation/physiology ; Male ; Memory/physiology ; Mice ; Motor Cortex/cytology/physiology ; *Neuronal Plasticity ; Psychomotor Performance/physiology ; Pyramidal Cells/metabolism ; Time Factors
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  • 40
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    Nature Publishing Group (NPG)
    Publication Date: 2015-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, Bryn -- England -- Nature. 2015 Apr 30;520(7549):711-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25932490" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Africa, Western/epidemiology ; Biotechnology ; Clinical Trials as Topic ; Drug Industry ; Ebola Vaccines/adverse effects/*supply & distribution ; Great Britain ; Health Education ; Hemorrhagic Fever, Ebola/epidemiology/prevention & control ; Humans ; Internationality ; *Public Health/education/manpower ; Risk Management ; Time Factors ; Trust ; World Health Organization
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  • 41
    Publication Date: 2015-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Richard G -- Lian, Olav B -- England -- Nature. 2015 Apr 23;520(7548):438-9. doi: 10.1038/520438a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Archaeological Science, School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Department of Geography and the Environment, University of the Fraser Valley, Abbotsford, British Columbia V2S 7M8, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25903619" target="_blank"〉PubMed〈/a〉
    Keywords: Aluminum Silicates/chemistry/radiation effects ; *Chronology as Topic ; *Electrons ; Extraterrestrial Environment/chemistry ; Geologic Sediments/*chemistry ; Lasers ; Mars ; Optics and Photonics/*methods ; Potassium Compounds/chemistry/radiation effects ; Quartz/chemistry/radiation effects ; Radiation, Ionizing ; Radiometric Dating ; *Sunlight ; Time Factors
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  • 42
    Publication Date: 2015-02-18
    Description: Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nitrogen. But these sources may have been small on the early Earth, severely limiting the size of the primordial biosphere. The evolution of the nitrogen-fixing enzyme nitrogenase, which reduces atmospheric N2 to organic NH4(+), thus represented a major breakthrough in the radiation of life, but its timing is uncertain. Here we present nitrogen isotope ratios with a mean of 0.0 +/- 1.2 per thousand from marine and fluvial sedimentary rocks of prehnite-pumpellyite to greenschist metamorphic grade between 3.2 and 2.75 billion years ago. These data cannot readily be explained by abiotic processes and therefore suggest biological nitrogen fixation, most probably using molybdenum-based nitrogenase as opposed to other variants that impart significant negative fractionations. Our data place a minimum age constraint of 3.2 billion years on the origin of biological nitrogen fixation and suggest that molybdenum was bioavailable in the mid-Archaean ocean long before the Great Oxidation Event.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stueken, Eva E -- Buick, Roger -- Guy, Bradley M -- Koehler, Matthew C -- England -- Nature. 2015 Apr 30;520(7549):666-9. doi: 10.1038/nature14180. Epub 2015 Feb 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth &Space Sciences and Astrobiology Program, University of Washington, Seattle, Washington 98195-1310, USA. ; Department of Geology, University of Johannesburg, Auckland Park 2006, South Africa.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25686600" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Evolution, Molecular ; Geologic Sediments/chemistry ; History, Ancient ; Molybdenum/*metabolism ; *Nitrogen Fixation ; Nitrogen Isotopes/*analysis ; Nitrogenase/*metabolism ; Oceans and Seas ; Oxidation-Reduction ; Time Factors
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  • 43
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    Nature Publishing Group (NPG)
    Publication Date: 2015-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- England -- Nature. 2015 Jan 8;517(7533):130-1. doi: 10.1038/517130a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25567262" target="_blank"〉PubMed〈/a〉
    Keywords: Antidepressive Agents/pharmacology ; Brain/drug effects ; Clinical Trials as Topic ; Depression/*drug therapy/psychology ; Glutamic Acid/metabolism ; Humans ; Ketamine/adverse effects/pharmacology/*therapeutic use ; Neuroimaging ; Off-Label Use ; Patents as Topic ; Suicide/prevention & control/psychology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 44
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    Nature Publishing Group (NPG)
    Publication Date: 2015-03-13
    Description: Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record against the formal requirements for the recognition of a new epoch. The evidence suggests that of the various proposed dates two do appear to conform to the criteria to mark the beginning of the Anthropocene: 1610 and 1964. The formal establishment of an Anthropocene Epoch would mark a fundamental change in the relationship between humans and the Earth system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, Simon L -- Maslin, Mark A -- England -- Nature. 2015 Mar 12;519(7542):171-80. doi: 10.1038/nature14258.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Geography, University College London, Gower Street, London, WC1E 6BT, UK [2] School of Geography, University of Leeds, Leeds, LS2 9JT, UK. ; Department of Geography, University College London, Gower Street, London, WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25762280" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/history ; Atmosphere/chemistry ; Carbon Dioxide/analysis ; *Chronology as Topic ; *Environment ; Geology/*methods ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Human Activities/*history ; Industry/history ; Population Dynamics ; Time Factors
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  • 45
    Publication Date: 2015-07-24
    Description: Sedimentary rocks deposited across the Proterozoic-Phanerozoic transition record extreme climate fluctuations, a potential rise in atmospheric oxygen or re-organization of the seafloor redox landscape, and the initial diversification of animals. It is widely assumed that the inferred redox change facilitated the observed trends in biodiversity. Establishing this palaeoenvironmental context, however, requires that changes in marine redox structure be tracked by means of geochemical proxies and translated into estimates of atmospheric oxygen. Iron-based proxies are among the most effective tools for tracking the redox chemistry of ancient oceans. These proxies are inherently local, but have global implications when analysed collectively and statistically. Here we analyse about 4,700 iron-speciation measurements from shales 2,300 to 360 million years old. Our statistical analyses suggest that subsurface water masses in mid-Proterozoic oceans were predominantly anoxic and ferruginous (depleted in dissolved oxygen and iron-bearing), but with a tendency towards euxinia (sulfide-bearing) that is not observed in the Neoproterozoic era. Analyses further indicate that early animals did not experience appreciable benthic sulfide stress. Finally, unlike proxies based on redox-sensitive trace-metal abundances, iron geochemical data do not show a statistically significant change in oxygen content through the Ediacaran and Cambrian periods, sharply constraining the magnitude of the end-Proterozoic oxygen increase. Indeed, this re-analysis of trace-metal data is consistent with oxygenation continuing well into the Palaeozoic era. Therefore, if changing redox conditions facilitated animal diversification, it did so through a limited rise in oxygen past critical functional and ecological thresholds, as is seen in modern oxygen minimum zone benthic animal communities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sperling, Erik A -- Wolock, Charles J -- Morgan, Alex S -- Gill, Benjamin C -- Kunzmann, Marcus -- Halverson, Galen P -- Macdonald, Francis A -- Knoll, Andrew H -- Johnston, David T -- England -- Nature. 2015 Jul 23;523(7561):451-4. doi: 10.1038/nature14589.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Earth and Planetary Sciences, Harvard University, Cambridge, Massachusetts 02138, USA [2] Integrative Oceanography Division, Scripps Institution of Oceanography, La Jolla, California 90089, USA. ; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. ; Department of Earth and Planetary Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. ; Department of Geosciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. ; Department of Earth and Planetary Sciences/GEOTOP, McGill University, Montreal, Quebec, H3A 0E8, Canada. ; 1] Department of Earth and Planetary Sciences, Harvard University, Cambridge, Massachusetts 02138, USA [2] Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26201598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere/chemistry ; Biodiversity ; Geologic Sediments/chemistry ; History, Ancient ; Iron/*analysis/*chemistry ; Oceans and Seas ; Oxidation-Reduction ; Oxygen/*analysis/*chemistry/metabolism ; Seawater/chemistry ; Sulfides/metabolism ; Time Factors
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  • 46
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    Nature Publishing Group (NPG)
    Publication Date: 2015-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Sep 24;525(7570):425. doi: 10.1038/525425a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26399790" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms/*drug effects ; California ; Cosmetics/*chemistry/poisoning ; Environmental Pollutants/chemistry/*poisoning ; Environmental Pollution/*legislation & jurisprudence/*prevention & control ; Food Contamination/analysis/prevention & control ; Humans ; *Microspheres ; Plastics/chemistry/*poisoning ; Public Health/legislation & jurisprudence ; Time Factors
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  • 47
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    Nature Publishing Group (NPG)
    Publication Date: 2015-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- England -- Nature. 2015 Dec 3;528(7580):19. doi: 10.1038/nature.2015.18870.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26632568" target="_blank"〉PubMed〈/a〉
    Keywords: Anxiety/physiopathology ; Biomarkers/blood/metabolism ; Brain/anatomy & histology/*metabolism/*physiopathology ; Case-Control Studies ; Depression/physiopathology ; Humans ; Ketamine/pharmacology/therapeutic use ; Risk Assessment ; Serotonin/analysis/metabolism ; *Suicide/prevention & control/psychology ; Time Factors
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  • 48
    Publication Date: 2015-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- Callaway, Ewen -- Castelvecchi, Davide -- Morello, Lauren -- Reardon, Sara -- Schiermeier, Quirin -- Witze, Alexandra -- England -- Nature. 2015 Dec 24;528(7583):448-51. doi: 10.1038/528448a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26701034" target="_blank"〉PubMed〈/a〉
    Keywords: CRISPR-Cas Systems/genetics ; Congresses as Topic ; Cryoelectron Microscopy ; Dengue Vaccines/supply & distribution ; Earthquakes/statistics & numerical data ; Ebola Vaccines/immunology ; Genetic Engineering/ethics/legislation & jurisprudence ; Global Warming/legislation & jurisprudence/prevention & control ; Humans ; Hydraulic Fracking/statistics & numerical data ; International Cooperation ; Malaria Vaccines/immunology ; Paris ; Physics ; Pluto ; Precision Medicine ; Reproducibility of Results ; Research/standards ; *Science ; Sexism/statistics & numerical data ; Space Flight
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  • 49
    Publication Date: 2015-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monastersky, Richard -- England -- Nature. 2015 Nov 5;527(7576):26-9. doi: 10.1038/527026a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26536941" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/history ; Archaeology ; Civilization/*history ; Climate ; Colorado ; Computer Simulation ; Droughts/history ; History, Medieval ; Human Migration/*history ; New Mexico ; Politics ; Time Factors ; Violence
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  • 50
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    Nature Publishing Group (NPG)
    Publication Date: 2015-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Aug 27;524(7566):387. doi: 10.1038/524387a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26310730" target="_blank"〉PubMed〈/a〉
    Keywords: Benzimidazoles/adverse effects/pharmacology ; Drug Approval/*legislation & jurisprudence ; Female ; Humans ; Lobbying ; Male ; Sex Factors ; Time Factors ; United States ; United States Food and Drug Administration/*ethics/*legislation & jurisprudence ; Women's Health
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  • 51
    Publication Date: 2015-03-04
    Description: The climatic impact of CO2 and other greenhouse gases is usually quantified in terms of radiative forcing, calculated as the difference between estimates of the Earth's radiation field from pre-industrial and present-day concentrations of these gases. Radiative transfer models calculate that the increase in CO2 since 1750 corresponds to a global annual-mean radiative forcing at the tropopause of 1.82 +/- 0.19 W m(-2) (ref. 2). However, despite widespread scientific discussion and modelling of the climate impacts of well-mixed greenhouse gases, there is little direct observational evidence of the radiative impact of increasing atmospheric CO2. Here we present observationally based evidence of clear-sky CO2 surface radiative forcing that is directly attributable to the increase, between 2000 and 2010, of 22 parts per million atmospheric CO2. The time series of this forcing at the two locations-the Southern Great Plains and the North Slope of Alaska-are derived from Atmospheric Emitted Radiance Interferometer spectra together with ancillary measurements and thoroughly corroborated radiative transfer calculations. The time series both show statistically significant trends of 0.2 W m(-2) per decade (with respective uncertainties of +/-0.06 W m(-2) per decade and +/-0.07 W m(-2) per decade) and have seasonal ranges of 0.1-0.2 W m(-2). This is approximately ten per cent of the trend in downwelling longwave radiation. These results confirm theoretical predictions of the atmospheric greenhouse effect due to anthropogenic emissions, and provide empirical evidence of how rising CO2 levels, mediated by temporal variations due to photosynthesis and respiration, are affecting the surface energy balance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, D R -- Collins, W D -- Gero, P J -- Torn, M S -- Mlawer, E J -- Shippert, T R -- England -- Nature. 2015 Mar 19;519(7543):339-43. doi: 10.1038/nature14240. Epub 2015 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lawrence Berkeley National Laboratory, Earth Sciences Division, 1 Cyclotron Road, MS 74R-316C, Berkeley, California 94720, USA. ; 1] Lawrence Berkeley National Laboratory, Earth Sciences Division, 1 Cyclotron Road, MS 74R-316C, Berkeley, California 94720, USA [2] University of California-Berkeley, Department of Earth and Planetary Science, 307 McCone Hall, MC 4767, Berkeley, California 94720, USA. ; University of Wisconsin-Madison, Space Science and Engineering Center, 1225 W. Dayton Street, Madison, Wisconsin 53706, USA. ; 1] Lawrence Berkeley National Laboratory, Earth Sciences Division, 1 Cyclotron Road, MS 74R-316C, Berkeley, California 94720, USA [2] University of California-Berkeley, Energy and Resources Group, Berkeley, 310 Barrows Hall, MC 3050, California 94720, USA. ; Atmospheric and Environmental Research, Inc., 131 Hartwell Avenue, Lexington, Massachusetts 02141, USA. ; Pacific Northwest National Laboratory, Fundamental and Computational Sciences, 902 Battelle Boulevard, Richland, Washington 99354, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25731165" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Atmosphere/chemistry ; *Carbon Dioxide/analysis ; Cell Respiration ; Greenhouse Effect/statistics & numerical data ; *Infrared Rays ; Models, Theoretical ; *Observation ; Photosynthesis ; Seasons ; Time Factors
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  • 52
    Publication Date: 2015-01-22
    Description: In a warming climate, surface meltwater production on large ice sheets is expected to increase. If this water is delivered to the ice sheet base it may have important consequences for ice dynamics. For example, basal water distributed in a diffuse network can decrease basal friction and accelerate ice flow, whereas channelized basal water can move quickly to the ice margin, where it can alter fjord circulation and submarine melt rates. Less certain is whether surface meltwater can be trapped and stored in subglacial lakes beneath large ice sheets. Here we show that a subglacial lake in Greenland drained quickly, as seen in the collapse of the ice surface, and then refilled from surface meltwater input. We use digital elevation models from stereo satellite imagery and airborne measurements to resolve elevation changes during the evolution of the surface and basal hydrologic systems at the Flade Isblink ice cap in northeast Greenland. During the autumn of 2011, a collapse basin about 70 metres deep and about 0.4 cubic kilometres in volume formed near the southern summit of the ice cap as a subglacial lake drained into a nearby fjord. Over the next two years, rapid uplift of the floor of the basin (which is approximately 8.4 square kilometres in area) occurred as surface meltwater flowed into crevasses around the basin margin and refilled the subglacial lake. Our observations show that surface meltwater can be trapped and stored at the bed of an ice sheet. Sensible and latent heat released by this trapped meltwater could soften nearby colder basal ice and alter downstream ice dynamics. Heat transport associated with meltwater trapped in subglacial lakes should be considered when predicting how ice sheet behaviour will change in a warming climate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willis, Michael J -- Herried, Bradley G -- Bevis, Michael G -- Bell, Robin E -- England -- Nature. 2015 Feb 12;518(7538):223-7. doi: 10.1038/nature14116. Epub 2015 Jan 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Earth and Atmospheric Sciences, Cornell University, Ithaca, New York 14853, USA [2] Department of Geological Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA. ; Polar Geospatial Center, University of Minnesota, Saint Paul, Minnesota 55108, USA. ; School of Earth Sciences, Ohio State University, Columbus, Ohio 43210, USA. ; Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25607355" target="_blank"〉PubMed〈/a〉
    Keywords: Altitude ; Freezing ; Global Warming ; Greenland ; Hydrology ; Ice Cover/*chemistry ; Lakes/*chemistry ; Models, Theoretical ; Rivers/chemistry ; Seasons ; Temperature ; Time Factors ; *Water Movements
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  • 53
    Publication Date: 2015-04-17
    Description: Abrupt climate change is a ubiquitous feature of the Late Pleistocene epoch. In particular, the sequence of Dansgaard-Oeschger events (repeated transitions between warm interstadial and cold stadial conditions), as recorded by ice cores in Greenland, are thought to be linked to changes in the mode of overturning circulation in the Atlantic Ocean. Moreover, the observed correspondence between North Atlantic cold events and increased iceberg calving and dispersal from ice sheets surrounding the North Atlantic has inspired many ocean and climate modelling studies that make use of freshwater forcing scenarios to simulate abrupt change across the North Atlantic region and beyond. On the other hand, previous studies identified an apparent lag between North Atlantic cooling events and the appearance of ice-rafted debris over the last glacial cycle, leading to the hypothesis that iceberg discharge may be a consequence of stadial conditions rather than the cause. Here we further establish this relationship and demonstrate a systematic delay between pronounced surface cooling and the arrival of ice-rafted debris at a site southwest of Iceland over the past four glacial cycles, implying that in general icebergs arrived too late to have triggered cooling. Instead we suggest that--on the basis of our comparisons of ice-rafted debris and polar planktonic foraminifera--abrupt transitions to stadial conditions should be considered as a nonlinear response to more gradual cooling across the North Atlantic. Although the freshwater derived from melting icebergs may provide a positive feedback for enhancing and or prolonging stadial conditions, it does not trigger northern stadial events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, Stephen -- Chen, James -- Gong, Xun -- Jonkers, Lukas -- Knorr, Gregor -- Thornalley, David -- England -- Nature. 2015 Apr 16;520(7547):333-6. doi: 10.1038/nature14330.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Earth and Ocean Sciences, Cardiff University, Cardiff CF10 3AT, UK. ; Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bussestrasse 24, D-27570 Bremerhaven, Germany. ; 1] Department of Geography, University College London, London WC1E 6BT, UK. [2] Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25877202" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Climate Change/*history ; *Cold Temperature ; Foraminifera/isolation & purification ; Greenland ; History, Ancient ; *Ice Cover ; Iceland ; Models, Theoretical ; Time Factors ; Water Movements
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  • 54
    Publication Date: 2015-03-06
    Description: In Drosophila, rapid temperature changes are detected at the periphery by dedicated receptors forming a simple sensory map for hot and cold in the brain. However, flies show a host of complex innate and learned responses to temperature, indicating that they are able to extract a range of information from this simple input. Here we define the anatomical and physiological repertoire for temperature representation in the Drosophila brain. First, we use a photolabelling strategy to trace the connections that relay peripheral thermosensory information to higher brain centres, and show that they largely converge onto three target regions: the mushroom body, the lateral horn (both of which are well known centres for sensory processing) and the posterior lateral protocerebrum, a region we now define as a major site of thermosensory representation. Next, using in vivo calcium imaging, we describe the thermosensory projection neurons selectively activated by hot or cold stimuli. Fast-adapting neurons display transient ON and OFF responses and track rapid temperature shifts remarkably well, while slow-adapting cell responses better reflect the magnitude of simple thermal changes. Unexpectedly, we also find a population of broadly tuned cells that respond to both heating and cooling, and show that they are required for normal behavioural avoidance of both hot and cold in a simple two-choice temperature preference assay. Taken together, our results uncover a coordinated ensemble of neural responses to temperature in the Drosophila brain, demonstrate that a broadly tuned thermal line contributes to rapid avoidance behaviour, and illustrate how stimulus quality, temporal structure, and intensity can be extracted from a simple glomerular map at a single synaptic station.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554763/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554763/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frank, Dominic D -- Jouandet, Genevieve C -- Kearney, Patrick J -- Macpherson, Lindsey J -- Gallio, Marco -- 1R01NS086859-01/NS/NINDS NIH HHS/ -- 2T32MH067564/MH/NIMH NIH HHS/ -- R01 NS076774/NS/NINDS NIH HHS/ -- R01 NS086859/NS/NINDS NIH HHS/ -- T32 MH067564/MH/NIMH NIH HHS/ -- England -- Nature. 2015 Mar 19;519(7543):358-61. doi: 10.1038/nature14284. Epub 2015 Mar 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Northwestern University, Evanston, Illinois 60208, USA. ; Departments of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25739506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/anatomy & histology/cytology/*physiology ; Brain Mapping ; Calcium/analysis/metabolism ; Drosophila melanogaster/cytology/*physiology ; Mushroom Bodies/innervation ; *Neural Pathways ; Neurons/metabolism ; Synapses/metabolism ; *Temperature ; Thermoreceptors/metabolism ; Thermosensing/*physiology ; Time Factors
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  • 55
    Publication Date: 2015-03-04
    Description: Evolution of large asexual cell populations underlies approximately 30% of deaths worldwide, including those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying these evolutionary processes remain poorly understood because they involve many competing beneficial lineages, most of which never rise above extremely low frequencies in the population. To observe these normally hidden evolutionary dynamics, we constructed a sequencing-based ultra high-resolution lineage tracking system in Saccharomyces cerevisiae that allowed us to monitor the relative frequencies of approximately 500,000 lineages simultaneously. In contrast to some expectations, we found that the spectrum of fitness effects of beneficial mutations is neither exponential nor monotonic. Early adaptation is a predictable consequence of this spectrum and is strikingly reproducible, but the initial small-effect mutations are soon outcompeted by rarer large-effect mutations that result in variability between replicates. These results suggest that early evolutionary dynamics may be deterministic for a period of time before stochastic effects become important.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426284/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426284/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, Sasha F -- Blundell, Jamie R -- Venkataram, Sandeep -- Petrov, Dmitri A -- Fisher, Daniel S -- Sherlock, Gavin -- 5-T32-HG-44-17/HG/NHGRI NIH HHS/ -- R01 HG003328/HG/NHGRI NIH HHS/ -- R25 GM067110/GM/NIGMS NIH HHS/ -- T32 HG000044/HG/NHGRI NIH HHS/ -- England -- Nature. 2015 Mar 12;519(7542):181-6. doi: 10.1038/nature14279. Epub 2015 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Genetics, Stanford University, Stanford, California 94305-5120, USA [2] Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794-5252, USA [3] Department of Biochemistry and Cellular Biology, Stony Brook University, Stony Brook, New York 11794-5215, USA. ; 1] Department of Applied Physics, Stanford University, Stanford, California 94305, USA [2] Department of Biology, Stanford University, Stanford, California 94305, USA. ; Department of Biology, Stanford University, Stanford, California 94305, USA. ; Department of Genetics, Stanford University, Stanford, California 94305-5120, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25731169" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Lineage/genetics ; Cell Tracking/*methods ; DNA Barcoding, Taxonomic/methods ; *Evolution, Molecular ; Genetic Fitness/genetics ; Mutagenesis/genetics ; Mutation Rate ; Saccharomyces cerevisiae/*cytology/genetics ; Time Factors
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  • 56
    Publication Date: 2015-09-01
    Description: Dopamine neurons are thought to facilitate learning by comparing actual and expected reward. Despite two decades of investigation, little is known about how this comparison is made. To determine how dopamine neurons calculate prediction error, we combined optogenetic manipulations with extracellular recordings in the ventral tegmental area while mice engaged in classical conditioning. Here we demonstrate, by manipulating the temporal expectation of reward, that dopamine neurons perform subtraction, a computation that is ideal for reinforcement learning but rarely observed in the brain. Furthermore, selectively exciting and inhibiting neighbouring GABA (gamma-aminobutyric acid) neurons in the ventral tegmental area reveals that these neurons are a source of subtraction: they inhibit dopamine neurons when reward is expected, causally contributing to prediction-error calculations. Finally, bilaterally stimulating ventral tegmental area GABA neurons dramatically reduces anticipatory licking to conditioned odours, consistent with an important role for these neurons in reinforcement learning. Together, our results uncover the arithmetic and local circuitry underlying dopamine prediction errors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567485/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567485/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eshel, Neir -- Bukwich, Michael -- Rao, Vinod -- Hemmelder, Vivian -- Tian, Ju -- Uchida, Naoshige -- F30 MH100729/MH/NIMH NIH HHS/ -- F30MH100729/MH/NIMH NIH HHS/ -- R01 MH095953/MH/NIMH NIH HHS/ -- R01 MH101207/MH/NIMH NIH HHS/ -- R01MH095953/MH/NIMH NIH HHS/ -- R01MH101207/MH/NIMH NIH HHS/ -- T32 GM007753/GM/NIGMS NIH HHS/ -- T32GM007753/GM/NIGMS NIH HHS/ -- England -- Nature. 2015 Sep 10;525(7568):243-6. doi: 10.1038/nature14855. Epub 2015 Aug 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26322583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning, Classical ; Dopamine/*metabolism ; Dopaminergic Neurons/*metabolism ; GABAergic Neurons/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; *Models, Neurological ; Neural Pathways/*physiology ; Odors/analysis ; Optogenetics ; Reinforcement (Psychology) ; Reward ; Time Factors ; Ventral Tegmental Area/*cytology/*physiology ; gamma-Aminobutyric Acid/metabolism
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  • 57
    Publication Date: 2015-11-27
    Description: Non-invasive imaging deep into organs at microscopic scales remains an open quest in biomedical imaging. Although optical microscopy is still limited to surface imaging owing to optical wave diffusion and fast decorrelation in tissue, revolutionary approaches such as fluorescence photo-activated localization microscopy led to a striking increase in resolution by more than an order of magnitude in the last decade. In contrast with optics, ultrasonic waves propagate deep into organs without losing their coherence and are much less affected by in vivo decorrelation processes. However, their resolution is impeded by the fundamental limits of diffraction, which impose a long-standing trade-off between resolution and penetration. This limits clinical and preclinical ultrasound imaging to a sub-millimetre scale. Here we demonstrate in vivo that ultrasound imaging at ultrafast frame rates (more than 500 frames per second) provides an analogue to optical localization microscopy by capturing the transient signal decorrelation of contrast agents--inert gas microbubbles. Ultrafast ultrasound localization microscopy allowed both non-invasive sub-wavelength structural imaging and haemodynamic quantification of rodent cerebral microvessels (less than ten micrometres in diameter) more than ten millimetres below the tissue surface, leading to transcranial whole-brain imaging within short acquisition times (tens of seconds). After intravenous injection, single echoes from individual microbubbles were detected through ultrafast imaging. Their localization, not limited by diffraction, was accumulated over 75,000 images, yielding 1,000,000 events per coronal plane and statistically independent pixels of ten micrometres in size. Precise temporal tracking of microbubble positions allowed us to extract accurately in-plane velocities of the blood flow with a large dynamic range (from one millimetre per second to several centimetres per second). These results pave the way for deep non-invasive microscopy in animals and humans using ultrasound. We anticipate that ultrafast ultrasound localization microscopy may become an invaluable tool for the fundamental understanding and diagnostics of various disease processes that modify the microvascular blood flow, such as cancer, stroke and arteriosclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Errico, Claudia -- Pierre, Juliette -- Pezet, Sophie -- Desailly, Yann -- Lenkei, Zsolt -- Couture, Olivier -- Tanter, Mickael -- England -- Nature. 2015 Nov 26;527(7579):499-502. doi: 10.1038/nature16066.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM, Institut Langevin, 1 rue Jussieu, 75005 Paris, France. ; Institut Langevin, ESPCI-ParisTech, PSL Research University, 1 rue Jussieu, 75005 Paris, France. ; CNRS UMR 7587, 1 rue Jussieu, 75005 Paris, France. ; CNRS, UMR 8249, 10 rue Vauquelin, 75005 Paris, France. ; Brain Plasticity Unit, ESPCI-ParisTech, PSL Research University, 10 rue Vauquelin, 75005 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26607546" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply/cytology ; Contrast Media ; Male ; Microbubbles ; Microscopy/*methods ; *Microvessels ; Molecular Imaging/*methods ; Optics and Photonics ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Ultrasonics/*methods
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  • 58
    Publication Date: 2015-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michel-Kerjan, Erwann -- England -- Nature. 2015 Jan 22;517(7535):413. doi: 10.1038/517413a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25612017" target="_blank"〉PubMed〈/a〉
    Keywords: Decision Making ; Disaster Planning/*methods ; International Cooperation ; Leadership ; Paris ; Research Report ; Risk Assessment/methods ; Risk Management/*methods ; Terrorism/prevention & control ; Time Factors ; Uncertainty
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  • 59
    Publication Date: 2015-02-13
    Description: Grid cells are neurons with periodic spatial receptive fields (grids) that tile two-dimensional space in a hexagonal pattern. To provide useful information about location, grids must be stably anchored to an external reference frame. The mechanisms underlying this anchoring process have remained elusive. Here we show in differently sized familiar square enclosures that the axes of the grids are offset from the walls by an angle that minimizes symmetry with the borders of the environment. This rotational offset is invariably accompanied by an elliptic distortion of the grid pattern. Reversing the ellipticity analytically by a shearing transformation removes the angular offset. This, together with the near-absence of rotation in novel environments, suggests that the rotation emerges through non-coaxial strain as a function of experience. The systematic relationship between rotation and distortion of the grid pattern points to shear forces arising from anchoring to specific geometric reference points as key elements of the mechanism for alignment of grid patterns to the external world.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stensola, Tor -- Stensola, Hanne -- Moser, May-Britt -- Moser, Edvard I -- England -- Nature. 2015 Feb 12;518(7538):207-12. doi: 10.1038/nature14151.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7491 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25673414" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Entorhinal Cortex/*cytology/physiology ; *Environment ; Male ; Models, Neurological ; Neurons/cytology/*physiology ; Orientation/*physiology ; Pattern Recognition, Visual/*physiology ; Rats ; Rats, Long-Evans ; Rotation ; Space Perception/*physiology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 60
    Publication Date: 2015-08-27
    Description: Most cancers in humans are large, measuring centimetres in diameter, and composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is that virtually every neoplastic cell within a large tumour often contains the same core set of genetic alterations, with heterogeneity confined to mutations that emerge late during tumour growth. How such alterations expand within the spatially constrained three-dimensional architecture of a tumour, and come to dominate a large, pre-existing lesion, has been unclear. Here we describe a model for tumour evolution that shows how short-range dispersal and cell turnover can account for rapid cell mixing inside the tumour. We show that even a small selective advantage of a single cell within a large tumour allows the descendants of that cell to replace the precursor mass in a clinically relevant time frame. We also demonstrate that the same mechanisms can be responsible for the rapid onset of resistance to chemotherapy. Our model not only provides insights into spatial and temporal aspects of tumour growth, but also suggests that targeting short-range cellular migratory activity could have marked effects on tumour growth rates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waclaw, Bartlomiej -- Bozic, Ivana -- Pittman, Meredith E -- Hruban, Ralph H -- Vogelstein, Bert -- Nowak, Martin A -- CA43460/CA/NCI NIH HHS/ -- CA62924/CA/NCI NIH HHS/ -- England -- Nature. 2015 Sep 10;525(7568):261-4. doi: 10.1038/nature14971. Epub 2015 Aug 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Physics and Astronomy, University of Edinburgh, JCMB, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK. ; Program for Evolutionary Dynamics, Harvard University, One Brattle Square, Cambridge, Massachusetts 02138, USA. ; Department of Mathematics, Harvard University, One Oxford Street, Cambridge, Massachusetts 02138, USA. ; The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, 401 North Broadway, Weinberg 2242, Baltimore, Maryland 21231, USA. ; Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, Maryland 21287, USA. ; Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26308893" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; *Cell Movement ; Drug Resistance, Neoplasm/genetics ; Evolution, Molecular ; Genetic Variation/*genetics ; Humans ; *Models, Biological ; Mutation/genetics ; Neoplasms/*genetics/metabolism/*pathology ; *Selection, Genetic ; Time Factors
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  • 61
    Publication Date: 2015-08-08
    Description: The source of new hepatocytes in the uninjured liver has remained an open question. By lineage tracing using the Wnt-responsive gene Axin2 in mice, we identify a population of proliferating and self-renewing cells adjacent to the central vein in the liver lobule. These pericentral cells express the early liver progenitor marker Tbx3, are diploid, and thereby differ from mature hepatocytes, which are mostly polyploid. The descendants of pericentral cells differentiate into Tbx3-negative, polyploid hepatocytes, and can replace all hepatocytes along the liver lobule during homeostatic renewal. Adjacent central vein endothelial cells provide Wnt signals that maintain the pericentral cells, thereby constituting the niche. Thus, we identify a cell population in the liver that subserves homeostatic hepatocyte renewal, characterize its anatomical niche, and identify molecular signals that regulate its activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589224/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589224/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Bruce -- Zhao, Ludan -- Fish, Matt -- Logan, Catriona Y -- Nusse, Roel -- F32DK091005/DK/NIDDK NIH HHS/ -- K08 DK101603/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Aug 13;524(7564):180-5. doi: 10.1038/nature14863. Epub 2015 Aug 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA [2] Department of Medicine and Liver Center, University of California San Francisco, San Francisco, California 94143, USA. ; Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26245375" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axin Protein/*metabolism ; Biomarkers/metabolism ; Cell Lineage ; Cell Proliferation ; Clone Cells/cytology/metabolism ; *Diploidy ; Endothelial Cells/metabolism ; Female ; Hepatocytes/*cytology/*metabolism ; *Homeostasis ; Liver/blood supply/*cytology ; Male ; Mice ; Polyploidy ; Regeneration ; Staining and Labeling ; Stem Cell Niche/physiology ; Stem Cells/cytology/metabolism ; T-Box Domain Proteins/deficiency/metabolism ; Time Factors ; Veins/cytology/metabolism ; Wnt Signaling Pathway
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  • 62
    Publication Date: 2015-05-02
    Description: When Staphylococcus aureus undergoes cytokinesis, it builds a septum, generating two hemispherical daughters whose cell walls are only connected via a narrow peripheral ring. We found that resolution of this ring occurred within milliseconds ("popping"), without detectable changes in cell volume. The likelihood of popping depended on cell-wall stress, and the separating cells split open asymmetrically, leaving the daughters connected by a hinge. An elastostatic model of the wall indicated high circumferential stress in the peripheral ring before popping. Last, we observed small perforations in the peripheral ring that are likely initial points of mechanical failure. Thus, the ultrafast daughter cell separation in S. aureus appears to be driven by accumulation of stress in the peripheral ring and exhibits hallmarks of mechanical crack propagation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhou, Xiaoxue -- Halladin, David K -- Rojas, Enrique R -- Koslover, Elena F -- Lee, Timothy K -- Huang, Kerwyn Casey -- Theriot, Julie A -- 1S10OD01227601/OD/NIH HHS/ -- DP2OD006466/OD/NIH HHS/ -- P50-GM107615/GM/NIGMS NIH HHS/ -- R01 AI036929/AI/NIAID NIH HHS/ -- R01-AI36929/AI/NIAID NIH HHS/ -- R37 AI036929/AI/NIAID NIH HHS/ -- T32 GM007276/GM/NIGMS NIH HHS/ -- T32-GM007276/GM/NIGMS NIH HHS/ -- U54-GM072970/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 May 1;348(6234):574-8. doi: 10.1126/science.aaa1511.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Stanford University, Stanford, CA 94305, USA. Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA 94305, USA. ; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. ; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. ; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA 94305, USA. ; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. ; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. ; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. theriot@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25931560" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/physiology/ultrastructure ; *Cytokinesis ; Microscopy, Electron, Scanning ; Microscopy, Video ; Staphylococcus aureus/cytology/*physiology/ultrastructure ; Stress, Mechanical ; Time Factors
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  • 63
    Publication Date: 2015-05-09
    Description: Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive interannual fluctuations in nonmeasles deaths. This is consistent with recent experimental work that attributes the immunosuppressive effects of measles to depletion of B and T lymphocytes. Our data provide an explanation for the long-term benefits of measles vaccination in preventing all-cause infectious disease. By preventing measles-associated immune memory loss, vaccination protects polymicrobial herd immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mina, Michael J -- Metcalf, C Jessica E -- de Swart, Rik L -- Osterhaus, A D M E -- Grenfell, Bryan T -- T32 GM008169/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 May 8;348(6235):694-9. doi: 10.1126/science.aaa3662. Epub 2015 May 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. Medical Scientist Training Program, School of Medicine, Emory University, Atlanta, GA, USA. michael.j.mina@gmail.com. ; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. Fogarty International Center, National Institutes of Health, Bethesda, MD, USA. ; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25954009" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/immunology ; Child ; *Child Mortality ; Child, Preschool ; England/epidemiology ; Female ; Humans ; Immunologic Memory ; *Immunomodulation ; Incidence ; Lymphocyte Depletion ; Male ; Measles/*epidemiology/*immunology/prevention & control ; Measles Vaccine/administration & dosage/*immunology ; Opportunistic Infections/immunology/*mortality/*prevention & control ; T-Lymphocytes/immunology ; Time Factors ; United States/epidemiology ; Vaccination ; Wales/epidemiology
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  • 64
    Publication Date: 2015-11-28
    Description: Protein domains can fold into stable tertiary structures while they are synthesized on the ribosome. We used a high-performance, reconstituted in vitro translation system to investigate the folding of a small five-helix protein domain-the N-terminal domain of Escherichia coli N5-glutamine methyltransferase HemK-in real time. Our observations show that cotranslational folding of the protein, which folds autonomously and rapidly in solution, proceeds through a compact, non-native conformation that forms within the peptide tunnel of the ribosome. The compact state rearranges into a native-like structure immediately after the full domain sequence has emerged from the ribosome. Both folding transitions are rate-limited by translation, allowing for quasi-equilibrium sampling of the conformational space restricted by the ribosome. Cotranslational folding may be typical of small, intrinsically rapidly folding protein domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holtkamp, Wolf -- Kokic, Goran -- Jager, Marcus -- Mittelstaet, Joerg -- Komar, Anton A -- Rodnina, Marina V -- New York, N.Y. -- Science. 2015 Nov 27;350(6264):1104-7. doi: 10.1126/science.aad0344.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany. ; Center for Gene Regulation in Health and Disease and Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA. ; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany. rodnina@mpibpc.mpg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26612953" target="_blank"〉PubMed〈/a〉
    Keywords: Escherichia coli Proteins/biosynthesis/chemistry ; Fluorescence Resonance Energy Transfer/*methods ; Peptides/chemistry ; *Protein Biosynthesis ; *Protein Folding ; Protein Methyltransferases/biosynthesis/chemistry ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteolysis ; Ribosomes/chemistry/*metabolism ; Time Factors
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2015-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jeremiah Y -- New York, N.Y. -- Science. 2015 Oct 2;350(6256):47. doi: 10.1126/science.aad3003.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jeremiah.cohen@jhmi.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26430113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Dopamine/*metabolism ; Dopaminergic Neurons/*metabolism ; Electric Stimulation ; Humans ; Mice ; Neurophysiology/trends ; *Reward ; Serotonin/*metabolism ; Signal Transduction ; Time Factors ; Ventral Tegmental Area/*cytology
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  • 66
    Publication Date: 2015-04-11
    Description: Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668944/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668944/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xue, Yali -- Prado-Martinez, Javier -- Sudmant, Peter H -- Narasimhan, Vagheesh -- Ayub, Qasim -- Szpak, Michal -- Frandsen, Peter -- Chen, Yuan -- Yngvadottir, Bryndis -- Cooper, David N -- de Manuel, Marc -- Hernandez-Rodriguez, Jessica -- Lobon, Irene -- Siegismund, Hans R -- Pagani, Luca -- Quail, Michael A -- Hvilsom, Christina -- Mudakikwa, Antoine -- Eichler, Evan E -- Cranfield, Michael R -- Marques-Bonet, Tomas -- Tyler-Smith, Chris -- Scally, Aylwyn -- 098051/Wellcome Trust/United Kingdom -- 099769/Z/12/Z/Wellcome Trust/United Kingdom -- 260372/European Research Council/International -- HG002385/HG/NHGRI NIH HHS/ -- R01 HG002385/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Apr 10;348(6231):242-5. doi: 10.1126/science.aaa3952. Epub 2015 Apr 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. ; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigacion Biomedica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain. ; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK. ; Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark. ; Institute of Medical Genetics, Cardiff University, Cardiff CF14 4XN, UK. ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Department of Biological, Geological and Environmental Sciences, University of Bologna, 40134 Bologna, Italy. ; Research and Conservation, Copenhagen Zoo, DK-2000 Frederiksberg, Denmark. ; Rwanda Development Board, KG 9 Avenue, Kigali, Rwanda. ; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Howard Hughes Medical Institute, Seattle, WA 91895, USA. ; Gorilla Doctors, Karen C. Drayer Wildlife Health Center, University of California, Davis, CA 95616, USA. ; Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigacion Biomedica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain. Centro Nacional de Analisis Genomico (Parc Cientific de Barcelona), Baldiri Reixac 4, 08028 Barcelona, Spain. ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. cts@sanger.ac.uk aos21@cam.ac.uk. ; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. cts@sanger.ac.uk aos21@cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25859046" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Biological Evolution ; DNA Copy Number Variations ; Democratic Republic of the Congo ; Endangered Species ; Female ; *Genetic Variation ; *Genome ; Gorilla gorilla/classification/*genetics/physiology ; Homozygote ; *Inbreeding ; Linkage Disequilibrium ; Male ; Mutation ; Population Dynamics ; Rwanda ; Selection, Genetic ; Sequence Analysis, DNA ; Species Specificity ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 67
    Publication Date: 2015-01-30
    Description: Estimating and accounting for twentieth-century global mean sea level (GMSL) rise is critical to characterizing current and future human-induced sea-level change. Several previous analyses of tide gauge records--employing different methods to accommodate the spatial sparsity and temporal incompleteness of the data and to constrain the geometry of long-term sea-level change--have concluded that GMSL rose over the twentieth century at a mean rate of 1.6 to 1.9 millimetres per year. Efforts to account for this rate by summing estimates of individual contributions from glacier and ice-sheet mass loss, ocean thermal expansion, and changes in land water storage fall significantly short in the period before 1990. The failure to close the budget of GMSL during this period has led to suggestions that several contributions may have been systematically underestimated. However, the extent to which the limitations of tide gauge analyses have affected estimates of the GMSL rate of change is unclear. Here we revisit estimates of twentieth-century GMSL rise using probabilistic techniques and find a rate of GMSL rise from 1901 to 1990 of 1.2 +/- 0.2 millimetres per year (90% confidence interval). Based on individual contributions tabulated in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, this estimate closes the twentieth-century sea-level budget. Our analysis, which combines tide gauge records with physics-based and model-derived geometries of the various contributing signals, also indicates that GMSL rose at a rate of 3.0 +/- 0.7 millimetres per year between 1993 and 2010, consistent with prior estimates from tide gauge records.The increase in rate relative to the 1901-90 trend is accordingly larger than previously thought; this revision may affect some projections of future sea-level rise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hay, Carling C -- Morrow, Eric -- Kopp, Robert E -- Mitrovica, Jerry X -- England -- Nature. 2015 Jan 22;517(7535):481-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25629092" target="_blank"〉PubMed〈/a〉
    Keywords: Bias (Epidemiology) ; Climate Change/statistics & numerical data ; History, 20th Century ; History, 21st Century ; Human Activities ; Oceans and Seas ; Probability ; Seawater/*analysis ; Tidal Waves ; Time Factors ; Uncertainty
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    Electronic ISSN: 1476-4687
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  • 68
    facet.materialart.
    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2015-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landskron, Kai -- England -- Nature. 2015 Jun 11;522(7555):247.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26065303" target="_blank"〉PubMed〈/a〉
    Keywords: Crowdsourcing/*economics/*methods ; Financing, Organized/economics ; Laboratories/*economics/manpower ; Nanotechnology/economics ; Research/*economics ; Research Personnel/*economics ; Research Support as Topic/economics/*methods ; Time Factors ; United States
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  • 69
    Publication Date: 2015-09-01
    Description: In all domains of life, DNA synthesis occurs bidirectionally from replication origins. Despite variable rates of replication fork progression, fork convergence often occurs at specific sites. Escherichia coli sets a 'replication fork trap' that allows the first arriving fork to enter but not to leave the terminus region. The trap is set by oppositely oriented Tus-bound Ter sites that block forks on approach from only one direction. However, the efficiency of fork blockage by Tus-Ter does not exceed 50% in vivo despite its apparent ability to almost permanently arrest replication forks in vitro. Here we use data from single-molecule DNA replication assays and structural studies to show that both polarity and fork-arrest efficiency are determined by a competition between rates of Tus displacement and rearrangement of Tus-Ter interactions that leads to blockage of slower moving replisomes by two distinct mechanisms. To our knowledge this is the first example where intrinsic differences in rates of individual replisomes have different biological outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elshenawy, Mohamed M -- Jergic, Slobodan -- Xu, Zhi-Qiang -- Sobhy, Mohamed A -- Takahashi, Masateru -- Oakley, Aaron J -- Dixon, Nicholas E -- Hamdan, Samir M -- England -- Nature. 2015 Sep 17;525(7569):394-8. doi: 10.1038/nature14866. Epub 2015 Aug 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia. ; Centre for Medical &Molecular Bioscience, Illawarra Health &Medical Research Institute and University of Wollongong, New South Wales 2522, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26322585" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding, Competitive ; Chromosomes, Bacterial/genetics/metabolism ; Crystallography, X-Ray ; *DNA Replication ; DNA-Directed DNA Polymerase/chemistry/*metabolism ; Escherichia coli/*genetics/metabolism ; Escherichia coli Proteins/chemistry/*metabolism ; Kinetics ; Models, Biological ; Models, Molecular ; Movement ; Multienzyme Complexes/chemistry/*metabolism ; Protein Conformation ; Regulatory Sequences, Nucleic Acid/*genetics ; Surface Plasmon Resonance ; Time Factors
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  • 70
    Publication Date: 2015-08-13
    Description: Tropical mountains are hot spots of biodiversity and endemism, but the evolutionary origins of their unique biotas are poorly understood. In varying degrees, local and regional extinction, long-distance colonization, and local recruitment may all contribute to the exceptional character of these communities. Also, it is debated whether mountain endemics mostly originate from local lowland taxa, or from lineages that reach the mountain by long-range dispersal from cool localities elsewhere. Here we investigate the evolutionary routes to endemism by sampling an entire tropical mountain biota on the 4,095-metre-high Mount Kinabalu in Sabah, East Malaysia. We discover that most of its unique biodiversity is younger than the mountain itself (6 million years), and comprises a mix of immigrant pre-adapted lineages and descendants from local lowland ancestors, although substantial shifts from lower to higher vegetation zones in this latter group were rare. These insights could improve forecasts of the likelihood of extinction and 'evolutionary rescue' in montane biodiversity hot spots under climate change scenarios.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merckx, Vincent S F T -- Hendriks, Kasper P -- Beentjes, Kevin K -- Mennes, Constantijn B -- Becking, Leontine E -- Peijnenburg, Katja T C A -- Afendy, Aqilah -- Arumugam, Nivaarani -- de Boer, Hugo -- Biun, Alim -- Buang, Matsain M -- Chen, Ping-Ping -- Chung, Arthur Y C -- Dow, Rory -- Feijen, Frida A A -- Feijen, Hans -- Feijen-van Soest, Cobi -- Geml, Jozsef -- Geurts, Rene -- Gravendeel, Barbara -- Hovenkamp, Peter -- Imbun, Paul -- Ipor, Isa -- Janssens, Steven B -- Jocque, Merlijn -- Kappes, Heike -- Khoo, Eyen -- Koomen, Peter -- Lens, Frederic -- Majapun, Richard J -- Morgado, Luis N -- Neupane, Suman -- Nieser, Nico -- Pereira, Joan T -- Rahman, Homathevi -- Sabran, Suzana -- Sawang, Anati -- Schwallier, Rachel M -- Shim, Phyau-Soon -- Smit, Harry -- Sol, Nicolien -- Spait, Maipul -- Stech, Michael -- Stokvis, Frank -- Sugau, John B -- Suleiman, Monica -- Sumail, Sukaibin -- Thomas, Daniel C -- van Tol, Jan -- Tuh, Fred Y Y -- Yahya, Bakhtiar E -- Nais, Jamili -- Repin, Rimi -- Lakim, Maklarin -- Schilthuizen, Menno -- England -- Nature. 2015 Aug 20;524(7565):347-50. doi: 10.1038/nature14949. Epub 2015 Aug 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands. ; Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands. ; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborg 7, 9747 AG Groningen, The Netherlands. ; Wageningen University &Research centre, Marine Animal Ecology Group, PO Box 338, 6700 AH Wageningen, The Netherlands. ; Department of Environmental Science, Policy, &Management, University of California Berkeley, 130 Mulford Hall #3114, Berkeley, California 94720, USA. ; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands. ; Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia. ; Faculty of Earth Science, Universiti Malaysia Kelantan, Jeli Campus, Locked bag No.100, 17600 Jeli, Kelantan Darul Naim, Malaysia. ; Department of Organismal Biology, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden. ; Natural History Museum, University of Oslo, P.O. Box 1172 Blindern, NO-0318 Oslo, Norway. ; Sabah Parks, Lot 45 &46, Level 1-5, Blok H, KK Times Square, 88806 Kota Kinabalu, Sabah, Malaysia. ; Forest Research Centre, Sabah Forestry Department, P.O. Box 1407, 90175 Sandakan, Sabah, Malaysia. ; Wageningen University, Department of Plant Sciences, Laboratory of Molecular Biology, 6700AP Wageningen, The Netherlands. ; University of Applied Sciences Leiden, Zernikedreef 11, 2333 CK Leiden, The Netherlands. ; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia. ; Botanic Garden Meise, Nieuwelaan 38, 1860 Meise, Belgium. ; Royal Belgian Institute of Natural Sciences, Aquatic and Terrestrial Ecology, Vautierstraat 29, 1000 Brussels, Belgium. ; Rutgers, The State University of New Jersey, Department of Biological Sciences, 195 University Avenue, Boyden Hall, Newark, New Jersey 07102, USA. ; Zoological Institute, University of Cologne, Zulpicher Strasse 47b, D-50674 Cologne, Germany. ; Natuurmuseum Fryslan, Schoenmakersperk 2, 8911 EM Leeuwarden, The Netherlands. ; EEB Department, University of Connecticut, 75 N. Eagleville Road, Storrs, Connecticut 06269-3043, USA. ; School of Biological Sciences, University of Hong Kong, Pok Fu Lam Road, Hong Kong, China. ; Singapore Botanic Gardens, 1 Cluny Road, 259569 Singapore, Republic of Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26266979" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; Animal Migration ; Animals ; *Biota ; Climate Change ; DNA Barcoding, Taxonomic ; Extinction, Biological ; Introduced Species/*statistics & numerical data ; Malaysia ; Molecular Sequence Data ; *Phylogeny ; *Phylogeography ; Plants/classification/genetics ; Time Factors ; *Tropical Climate
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  • 71
    Publication Date: 2015-12-23
    Description: The global occurrence in water resources of organic micropollutants, such as pesticides and pharmaceuticals, has raised concerns about potential negative effects on aquatic ecosystems and human health. Activated carbons are the most widespread adsorbent materials used to remove organic pollutants from water but they have several deficiencies, including slow pollutant uptake (of the order of hours) and poor removal of many relatively hydrophilic micropollutants. Furthermore, regenerating spent activated carbon is energy intensive (requiring heating to 500-900 degrees Celsius) and does not fully restore performance. Insoluble polymers of beta-cyclodextrin, an inexpensive, sustainably produced macrocycle of glucose, are likewise of interest for removing micropollutants from water by means of adsorption. beta-cyclodextrin is known to encapsulate pollutants to form well-defined host-guest complexes, but until now cross-linked beta-cyclodextrin polymers have had low surface areas and poor removal performance compared to conventional activated carbons. Here we crosslink beta-cyclodextrin with rigid aromatic groups, providing a high-surface-area, mesoporous polymer of beta-cyclodextrin. It rapidly sequesters a variety of organic micropollutants with adsorption rate constants 15 to 200 times greater than those of activated carbons and non-porous beta-cyclodextrin adsorbent materials. In addition, the polymer can be regenerated several times using a mild washing procedure with no loss in performance. Finally, the polymer outperformed a leading activated carbon for the rapid removal of a complex mixture of organic micropollutants at environmentally relevant concentrations. These findings demonstrate the promise of porous cyclodextrin-based polymers for rapid, flow-through water treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alsbaiee, Alaaeddin -- Smith, Brian J -- Xiao, Leilei -- Ling, Yuhan -- Helbling, Damian E -- Dichtel, William R -- England -- Nature. 2016 Jan 14;529(7585):190-4. doi: 10.1038/nature16185. Epub 2015 Dec 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, New York 14853, USA. ; School of Civil and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26689365" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; Benzhydryl Compounds/chemistry/isolation & purification ; Cellulose/chemical synthesis/*chemistry ; Charcoal/chemistry ; Cyclodextrins/chemical synthesis/*chemistry ; Phenols/chemistry/isolation & purification ; Porosity ; Recycling/economics/methods ; Temperature ; Time Factors ; Waste Disposal, Fluid/economics/methods ; Water/*chemistry ; Water Pollutants, Chemical/chemistry/*isolation & purification ; Water Purification/economics/*methods
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 72
    facet.materialart.
    Unknown
    Nature Publishing Group (NPG)
    Publication Date: 2015-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Mar 26;519(7544):S75. doi: 10.1038/519S75a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25806700" target="_blank"〉PubMed〈/a〉
    Keywords: *Bibliometrics ; *Databases, Factual ; Efficiency ; Internationality ; *Periodicals as Topic/standards/statistics & numerical data ; Publishing/*statistics & numerical data ; Research/standards/*statistics & numerical data ; Research Personnel/standards/*statistics & numerical data ; Time Factors
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  • 73
    Publication Date: 2015-04-02
    Description: In the context of most induced pluripotent stem (iPS) cell reprogramming methods, heterogeneous populations of non-productive and staggered productive intermediates arise at different reprogramming time points. Despite recent reports claiming substantially increased reprogramming efficiencies using genetically modified donor cells, prospectively isolating distinct reprogramming intermediates remains an important goal to decipher reprogramming mechanisms. Previous attempts to identify surface markers of intermediate cell populations were based on the assumption that, during reprogramming, cells progressively lose donor cell identity and gradually acquire iPS cell properties. Here we report that iPS cell and epithelial markers, such as SSEA1 and EpCAM, respectively, are not predictive of reprogramming during early phases. Instead, in a systematic functional surface marker screen, we find that early reprogramming-prone cells express a unique set of surface markers, including CD73, CD49d and CD200, that are absent in both fibroblasts and iPS cells. Single-cell mass cytometry and prospective isolation show that these distinct intermediates are transient and bridge the gap between donor cell silencing and pluripotency marker acquisition during the early, presumably stochastic, reprogramming phase. Expression profiling reveals early upregulation of the transcriptional regulators Nr0b1 and Etv5 in this reprogramming state, preceding activation of key pluripotency regulators such as Rex1 (also known as Zfp42), Dppa2, Nanog and Sox2. Both factors are required for the generation of the early intermediate state and fully reprogrammed iPS cells, and thus represent some of the earliest known regulators of iPS cell induction. Our study deconvolutes the first steps in a hierarchical series of events that lead to pluripotency acquisition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441548/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441548/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lujan, Ernesto -- Zunder, Eli R -- Ng, Yi Han -- Goronzy, Isabel N -- Nolan, Garry P -- Wernig, Marius -- F32 GM093508-01/GM/NIGMS NIH HHS/ -- RC4 NS073015/NS/NINDS NIH HHS/ -- England -- Nature. 2015 May 21;521(7552):352-6. doi: 10.1038/nature14274. Epub 2015 Apr 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA [2] Department of Genetics, Stanford University, Stanford, California 94305, USA [3] Department of Pathology, Stanford University, Stanford, California 94305, USA. ; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA. ; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA [2] Department of Pathology, Stanford University, Stanford, California 94305, USA [3] Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA. ; 1] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA [2] Department of Pathology, Stanford University, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25830878" target="_blank"〉PubMed〈/a〉
    Keywords: 5'-Nucleotidase/metabolism ; Animals ; Antigens, CD/metabolism ; Antigens, CD15/metabolism ; Antigens, Neoplasm/metabolism ; Biomarkers/analysis/metabolism ; Cell Adhesion Molecules/metabolism ; *Cell Separation ; Cellular Reprogramming/*physiology ; DAX-1 Orphan Nuclear Receptor/metabolism ; DNA-Binding Proteins/metabolism ; Epithelial Cells/metabolism ; Fibroblasts/cytology/metabolism ; *Flow Cytometry ; Gene Expression Profiling ; Homeodomain Proteins/metabolism ; Induced Pluripotent Stem Cells/*cytology/*metabolism ; Integrin alpha4/metabolism ; Mice ; Nuclear Proteins/metabolism ; SOXB1 Transcription Factors/metabolism ; Time Factors ; Transcription Factors/analysis/*metabolism
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  • 74
    Publication Date: 2015-12-04
    Description: Tuberculosis is a major source of global mortality caused by infection, partly because of a tremendous ongoing burden of undiagnosed disease. Improved diagnostic technology may play an increasingly crucial part in global efforts to end tuberculosis, but the ability of diagnostic tests to curb tuberculosis transmission is dependent on multiple factors, including the time taken by a patient to seek health care, the patient's symptoms, and the patterns of transmission before diagnosis. Novel diagnostic assays for tuberculosis have conventionally been evaluated on the basis of characteristics such as sensitivity and specificity, using assumptions that probably overestimate the impact of diagnostic tests on transmission. We argue for a shift in focus to the evaluation of such tests' incremental value, defining outcomes that reflect each test's purpose (for example, transmissions averted) and comparing systems with the test against those without, in terms of those outcomes. Incremental value can also be measured in units of outcome per incremental unit of resource (for example, money or human capacity). Using a novel, simplified model of tuberculosis transmission that addresses some of the limitations of earlier tuberculosis diagnostic models, we demonstrate that the incremental value of any novel test depends not just on its accuracy, but also on elements such as patient behaviour, tuberculosis natural history and health systems. By integrating these factors into a single unified framework, we advance an approach to the evaluation of new diagnostic tests for tuberculosis that considers the incremental value at the population level and demonstrates how additional data could inform more-effective implementation of tuberculosis diagnostic tests under various conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arinaminpathy, Nimalan -- Dowdy, David -- England -- Nature. 2015 Dec 3;528(7580):S60-7. doi: 10.1038/nature16045.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK. ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26633767" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; *Diagnostic Tests, Routine/economics/standards ; Health Resources/economics ; Humans ; Sensitivity and Specificity ; Time Factors ; Tuberculosis/*diagnosis/*prevention & control/transmission
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  • 75
    Publication Date: 2015-12-18
    Description: Understanding how ecological communities are organized and how they change through time is critical to predicting the effects of climate change. Recent work documenting the co-occurrence structure of modern communities found that most significant species pairs co-occur less frequently than would be expected by chance. However, little is known about how co-occurrence structure changes through time. Here we evaluate changes in plant and animal community organization over geological time by quantifying the co-occurrence structure of 359,896 unique taxon pairs in 80 assemblages spanning the past 300 million years. Co-occurrences of most taxon pairs were statistically random, but a significant fraction were spatially aggregated or segregated. Aggregated pairs dominated from the Carboniferous period (307 million years ago) to the early Holocene epoch (11,700 years before present), when there was a pronounced shift to more segregated pairs, a trend that continues in modern assemblages. The shift began during the Holocene and coincided with increasing human population size and the spread of agriculture in North America. Before the shift, an average of 64% of significant pairs were aggregated; after the shift, the average dropped to 37%. The organization of modern and late Holocene plant and animal assemblages differs fundamentally from that of assemblages over the past 300 million years that predate the large-scale impacts of humans. Our results suggest that the rules governing the assembly of communities have recently been changed by human activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyons, S Kathleen -- Amatangelo, Kathryn L -- Behrensmeyer, Anna K -- Bercovici, Antoine -- Blois, Jessica L -- Davis, Matt -- DiMichele, William A -- Du, Andrew -- Eronen, Jussi T -- Faith, J Tyler -- Graves, Gary R -- Jud, Nathan -- Labandeira, Conrad -- Looy, Cindy V -- McGill, Brian -- Miller, Joshua H -- Patterson, David -- Pineda-Munoz, Silvia -- Potts, Richard -- Riddle, Brett -- Terry, Rebecca -- Toth, Aniko -- Ulrich, Werner -- Villasenor, Amelia -- Wing, Scott -- Anderson, Heidi -- Anderson, John -- Waller, Donald -- Gotelli, Nicholas J -- England -- Nature. 2016 Jan 7;529(7584):80-3. doi: 10.1038/nature16447. Epub 2015 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Paleobiology, National Museum of Natural History, Smithsonian Institution, Washington DC 20013, USA. ; Department of Environmental Science and Biology, The College at Brockport - SUNY, Brockport, New York 14420, USA. ; School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, California 95343, USA. ; Department of Geology and Geophysics, Yale University, New Haven, Connecticut 06520, USA. ; Hominid Paleobiology Doctoral Program, Center for the Advanced Study of Hominid Paleobiology, Department of Anthropology, George Washington University, Washington DC 20052, USA. ; Department of Geosciences and Geography, University of Helsinki, PO Box 64, 00014 University of Helsinki, Finland. ; School of Social Science, The University of Queensland, Brisbane, Queensland 4072, Australia. ; Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington DC 20013, USA. ; Center for Macroecology, Evolution and Climate, University of Copenhagen, Copenhagen 2100, Denmark. ; Biological Sciences Graduate Program, University of Maryland, College Park, Maryland 20742, USA. ; Florida Museum of Natural History, University of Florida, Gainsville, Florida 32611, USA. ; Department of Entomology, University of Maryland College Park, College Park, Maryland 20742, USA. ; Key Lab of Insect Evolution and Environmental Changes, Capital Normal University, Beijing 100048, China. ; Department of Integrative Biology and Museum of Paleontology, University of California Berkeley, Berkeley, California 94720, USA. ; School Biology and Ecology &Sustainability Solutions Initiative, University of Maine, Orono, Maine 04469, USA. ; Department of Geology, University of Cincinnati, Cincinnati, Ohio 45221, USA. ; Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2109, Australia. ; Department of Anthropology, Human Origins Program, National Museum of Natural History, Smithsonian Institution, Washington DC 20013, USA. ; School of Life Sciences, University of Nevada-Las Vegas, Las Vegas, Nevada 89154, USA. ; Department of Integrative Biology, Oregon State University, Corvallis, Oregon 97331, USA. ; Chair of Ecology and Biogeography, Nicolaus Copernicus University, Lwowska 1, 87-100 Torun, Poland. ; Evolutionary Studies Institute, University of the Witwatersrand, Jorissen Street, Braamfontein, Johannesburg 2001, South Africa. ; Department of Botany, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. ; Department of Biology, University of Vermont, Burlington, Vermont 05405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26675730" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Animals ; *Ecosystem ; History, Ancient ; Human Activities/*history ; Humans ; North America ; *Plant Physiological Phenomena ; Population Dynamics ; Time Factors
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  • 76
    Publication Date: 2015-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yozwiak, Nathan L -- Schaffner, Stephen F -- Sabeti, Pardis C -- England -- Nature. 2015 Feb 26;518(7540):477-9. doi: 10.1038/518477a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute and Harvard University in Cambridge, Massachusetts, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25719649" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information/ethics ; Biomedical Research/ethics/*organization & administration ; *Cooperative Behavior ; Coronavirus Infections/epidemiology/virology ; Databases, Nucleic Acid ; *Disease Outbreaks/prevention & control/statistics & numerical data ; Ebolavirus/genetics ; Genomics/methods/organization & administration ; Guidelines as Topic ; Guinea/epidemiology ; *Hemorrhagic Fever, Ebola/diagnosis/epidemiology/therapy/virology ; Humans ; Influenza, Human/epidemiology/virology ; *Information Dissemination/ethics/methods ; International Cooperation ; Internet ; Publishing ; Research Personnel/organization & administration ; Sierra Leone/epidemiology ; Time Factors ; Virology/organization & administration
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  • 77
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    Nature Publishing Group (NPG)
    Publication Date: 2015-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2015 Mar 26;519(7544):S64-5. doi: 10.1038/519S64a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25806697" target="_blank"〉PubMed〈/a〉
    Keywords: Australia ; Biological Science Disciplines ; Biomedical Research ; Cooperative Behavior ; Humans ; Physics ; Politics ; Publishing/statistics & numerical data ; Renewable Energy ; Research/*economics/organization & administration/*statistics & numerical data
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  • 78
    Publication Date: 2015-12-04
    Description: Ebola emerged in West Africa around December 2013 and swept through Guinea, Sierra Leone and Liberia, giving rise to 27,748 confirmed, probable and suspected cases reported by 29 July 2015. Case diagnoses during the epidemic have relied on polymerase chain reaction-based tests. Owing to limited laboratory capacity and local transport infrastructure, the delays from sample collection to test results being available have often been 2 days or more. Point-of-care rapid diagnostic tests offer the potential to substantially reduce these delays. We review Ebola rapid diagnostic tests approved by the World Health Organization and those currently in development. Such rapid diagnostic tests could allow early triaging of patients, thereby reducing the potential for nosocomial transmission. In addition, despite the lower test accuracy, rapid diagnostic test-based diagnosis may be beneficial in some contexts because of the reduced time spent by uninfected individuals in health-care settings where they may be at increased risk of infection; this also frees up hospital beds. We use mathematical modelling to explore the potential benefits of diagnostic testing strategies involving rapid diagnostic tests alone and in combination with polymerase chain reaction testing. Our analysis indicates that the use of rapid diagnostic tests with sensitivity and specificity comparable with those currently under development always enhances control, whether evaluated at a health-care-unit or population level. If such tests had been available throughout the recent epidemic, we estimate, for Sierra Leone, that their use in combination with confirmatory polymerase chain-reaction testing might have reduced the scale of the epidemic by over a third.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nouvellet, Pierre -- Garske, Tini -- Mills, Harriet L -- Nedjati-Gilani, Gemma -- Hinsley, Wes -- Blake, Isobel M -- Van Kerkhove, Maria D -- Cori, Anne -- Dorigatti, Ilaria -- Jombart, Thibaut -- Riley, Steven -- Fraser, Christophe -- Donnelly, Christl A -- Ferguson, Neil M -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2015 Dec 3;528(7580):S109-16. doi: 10.1038/nature16041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK. ; Center for Global Health, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26633764" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western/epidemiology ; *Diagnostic Tests, Routine ; *Hemorrhagic Fever, Ebola/diagnosis/epidemiology/prevention & ; control/transmission ; Humans ; Time Factors ; Triage
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  • 79
    Publication Date: 2015-10-16
    Description: Studies of individual living cells have revealed that many transcription factors activate in dynamic, and often stochastic, pulses within the same cell. However, it has remained unclear whether cells might exploit the dynamic interaction of these pulses to control gene expression. Here, using quantitative single-cell time-lapse imaging of Saccharomyces cerevisiae, we show that the pulsatile transcription factors Msn2 and Mig1 combinatorially regulate their target genes through modulation of their relative pulse timing. The activator Msn2 and repressor Mig1 showed pulsed activation in either a temporally overlapping or non-overlapping manner during their transient response to different inputs, with only the non-overlapping dynamics efficiently activating target gene expression. Similarly, under constant environmental conditions, where Msn2 and Mig1 exhibit sporadic pulsing, glucose concentration modulated the temporal overlap between pulses of the two factors. Together, these results reveal a time-based mode of combinatorial gene regulation. Regulation through relative signal timing is common in engineering and neurobiology, and these results suggest that it could also function broadly within the signalling and regulatory systems of the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Yihan -- Sohn, Chang Ho -- Dalal, Chiraj K -- Cai, Long -- Elowitz, Michael B -- R01 GM079771/GM/NIGMS NIH HHS/ -- R01 GM079771B/GM/NIGMS NIH HHS/ -- R01 GM086793/GM/NIGMS NIH HHS/ -- R01 GM086793A/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Nov 5;527(7576):54-8. doi: 10.1038/nature15710. Epub 2015 Oct 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA. ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA. ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26466562" target="_blank"〉PubMed〈/a〉
    Keywords: DNA-Binding Proteins/metabolism ; *Gene Expression Regulation, Fungal ; Glucose/deficiency/metabolism ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Single-Cell Analysis ; Time Factors ; Time-Lapse Imaging ; Transcription Factors/metabolism
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  • 80
    Publication Date: 2015-11-13
    Description: Contraction of both skeletal muscle and the heart is thought to be controlled by a calcium-dependent structural change in the actin-containing thin filaments, which permits the binding of myosin motors from the neighbouring thick filaments to drive filament sliding. Here we show by synchrotron small-angle X-ray diffraction of frog (Rana temporaria) single skeletal muscle cells that, although the well-known thin-filament mechanism is sufficient for regulation of muscle shortening against low load, force generation against high load requires a second permissive step linked to a change in the structure of the thick filament. The resting (switched 'OFF') structure of the thick filament is characterized by helical tracks of myosin motors on the filament surface and a short backbone periodicity. This OFF structure is almost completely preserved during low-load shortening, which is driven by a small fraction of constitutively active (switched 'ON') myosin motors outside thick-filament control. At higher load, these motors generate sufficient thick-filament stress to trigger the transition to its long-periodicity ON structure, unlocking the major population of motors required for high-load contraction. This concept of the thick filament as a regulatory mechanosensor provides a novel explanation for the dynamic and energetic properties of skeletal muscle. A similar mechanism probably operates in the heart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linari, Marco -- Brunello, Elisabetta -- Reconditi, Massimo -- Fusi, Luca -- Caremani, Marco -- Narayanan, Theyencheri -- Piazzesi, Gabriella -- Lombardi, Vincenzo -- Irving, Malcolm -- England -- Nature. 2015 Dec 10;528(7581):276-9. doi: 10.1038/nature15727. Epub 2015 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Physiology, Department of Biology, Universita di Firenze, Sesto Fiorentino, 50019 Florence, Italy. ; Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, UdR Firenze, Sesto Fiorentino, 50019 Florence, Italy. ; Randall Division and BHF Centre for Research Excellence, King's College London, London SE1 1UL, UK. ; European Synchrotron Radiation Facility, BP220, F-38043 Grenoble, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26560032" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Male ; Mechanotransduction, Cellular/*physiology ; Muscle, Skeletal/*metabolism ; Myosins/*metabolism ; Rana temporaria ; Synchrotrons ; Time Factors ; X-Ray Diffraction
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  • 81
    Publication Date: 2015-05-29
    Description: Reinforcement learning is a branch of machine learning concerned with using experience gained through interacting with the world and evaluative feedback to improve a system's ability to make behavioural decisions. It has been called the artificial intelligence problem in a microcosm because learning algorithms must act autonomously to perform well and achieve their goals. Partly driven by the increasing availability of rich data, recent years have seen exciting advances in the theory and practice of reinforcement learning, including developments in fundamental technical areas such as generalization, planning, exploration and empirical methodology, leading to increasing applicability to real-life problems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Littman, Michael L -- England -- Nature. 2015 May 28;521(7553):445-51. doi: 10.1038/nature14540.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science, Brown University, Providence, Rhode Island 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26017443" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; *Artificial Intelligence ; Empirical Research ; *Feedback ; Markov Chains ; Monte Carlo Method ; Reward ; Time Factors
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  • 82
    Publication Date: 2015-01-07
    Description: Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ling, Losee L -- Schneider, Tanja -- Peoples, Aaron J -- Spoering, Amy L -- Engels, Ina -- Conlon, Brian P -- Mueller, Anna -- Schaberle, Till F -- Hughes, Dallas E -- Epstein, Slava -- Jones, Michael -- Lazarides, Linos -- Steadman, Victoria A -- Cohen, Douglas R -- Felix, Cintia R -- Fetterman, K Ashley -- Millett, William P -- Nitti, Anthony G -- Zullo, Ashley M -- Chen, Chao -- Lewis, Kim -- AI085612/AI/NIAID NIH HHS/ -- T-RO1AI085585/AI/NIAID NIH HHS/ -- England -- Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA. ; 1] Institute of Medical Microbiology, Immunology and Parasitology-Pharmaceutical Microbiology Section, University of Bonn, Bonn 53115, Germany [2] German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 53115 Bonn, Germany. ; Antimicrobial Discovery Center, Northeastern University, Department of Biology, Boston, Massachusetts 02115, USA. ; 1] German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, 53115 Bonn, Germany [2] Institute for Pharmaceutical Biology, University of Bonn, Bonn 53115, Germany. ; Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA. ; Selcia, Ongar, Essex CM5 0GS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25561178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/biosynthesis/chemistry/isolation & ; purification/*pharmacology ; Betaproteobacteria/chemistry/genetics ; Biological Products/chemistry/isolation & purification/pharmacology ; Cell Wall/chemistry/drug effects/metabolism ; Depsipeptides/biosynthesis/chemistry/isolation & purification/*pharmacology ; Disease Models, Animal ; *Drug Resistance, Microbial/genetics ; Female ; Mice ; Microbial Sensitivity Tests ; Microbial Viability/*drug effects ; Molecular Sequence Data ; Multigene Family/genetics ; Mycobacterium tuberculosis/cytology/*drug effects/genetics ; Peptidoglycan/biosynthesis ; Staphylococcal Infections/drug therapy/microbiology ; Staphylococcus aureus/chemistry/cytology/*drug effects/genetics ; Teichoic Acids/biosynthesis ; Time Factors
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  • 83
    Publication Date: 2015-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, Mark A -- England -- Nature. 2015 Apr 16;520(7547):290-1. doi: 10.1038/520290a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Precision Medicine at Weill Cornell Medical College and NewYork-Presbyterian Hospital in New York City, New York, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25877189" target="_blank"〉PubMed〈/a〉
    Keywords: Databases, Factual ; Electronic Health Records/*utilization ; Female ; Genetics, Medical/methods/trends ; Genome, Human/genetics ; Genomics/trends ; Humans ; Information Dissemination/*methods ; Molecular Targeted Therapy/trends/*utilization ; Neoplasms/*drug therapy/*genetics ; Pharmacogenetics/trends ; Precision Medicine/trends/*utilization ; Quinolines/adverse effects/therapeutic use ; Time Factors
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  • 84
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    Nature Publishing Group (NPG)
    Publication Date: 2015-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xiangmei, Chen -- Xuan, Zeng -- Li, Piao -- England -- Nature. 2015 Apr 30;520(7549):S26-7. doi: 10.1038/520S26a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25924196" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Child ; Child Rearing ; China ; Female ; Humans ; Male ; Parental Leave ; Pregnancy ; Research Personnel/education/psychology/*statistics & numerical data ; Sex Factors ; Sexism/psychology/*trends ; Time Factors
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  • 85
    Publication Date: 2015-09-25
    Description: Observations of cometary nuclei have revealed a very limited amount of surface water ice, which is insufficient to explain the observed water outgassing. This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volatiles) were only partially correlated with the exposed ice regions. The observations of 67P/Churyumov-Gerasimenko have revealed that activity has a diurnal variation in intensity arising from changing insolation conditions. It was previously concluded that water vapour was generated in ice-rich subsurface layers with a transport mechanism linked to solar illumination, but that has not hitherto been observed. Periodic condensations of water vapour very close to, or on, the surface were suggested to explain short-lived outbursts seen near sunrise on comet 9P/Tempel 1. Here we report observations of water ice on the surface of comet 67P/Churyumov-Gerasimenko, appearing and disappearing in a cyclic pattern that follows local illumination conditions, providing a source of localized activity. This water cycle appears to be an important process in the evolution of the comet, leading to cyclical modification of the relative abundance of water ice on its surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Sanctis, M C -- Capaccioni, F -- Ciarniello, M -- Filacchione, G -- Formisano, M -- Mottola, S -- Raponi, A -- Tosi, F -- Bockelee-Morvan, D -- Erard, S -- Leyrat, C -- Schmitt, B -- Ammannito, E -- Arnold, G -- Barucci, M A -- Combi, M -- Capria, M T -- Cerroni, P -- Ip, W-H -- Kuehrt, E -- McCord, T B -- Palomba, E -- Beck, P -- Quirico, E -- VIRTIS Team -- England -- Nature. 2015 Sep 24;525(7570):500-3. doi: 10.1038/nature14869.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto di Astrofisica e Planetologia Spaziali - INAF, via del fosso del cavaliere 100, 00133 Rome, Italy. ; Institute for Planetary Research, DLR, Rutherfordstrasse 2, 12489 Berlin, Germany. ; LESIA-Observatoire de Paris, CNRS, Universite Pierre et Marie Curie, Universite Paris Diderot, 5 place Jules Janssen, 92195 Meudon, France. ; Universite Grenoble Alpes - CNRS Institut de Planetologie et Astrophysique de Grenoble, Batiment D de Physique, BP 53, 38041 Grenoble Cedex 9, France. ; University of California, Los Angeles, California 90095, USA. ; Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, 2455 Hayward Street, Ann Arbor, Michigan 48109, USA. ; National Central University, No. 300, Jhongda Road, Jhongli District, Taoyuan City, 32001 Taipei, Taiwan. ; Bear Fight Institute, 22 Fiddler's Road, Box 667, Winthrop, Washington 98862, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26399830" target="_blank"〉PubMed〈/a〉
    Keywords: Extraterrestrial Environment/*chemistry ; Ice/*analysis ; *Meteoroids ; Temperature ; Time Factors ; Volatilization
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  • 86
    Publication Date: 2015-02-06
    Description: The platyrrhine primates, or New World monkeys, are immigrant mammals whose fossil record comes from Tertiary and Quaternary sediments of South America and the Caribbean Greater Antilles. The time and place of platyrrhine origins are some of the most controversial issues in primate palaeontology, although an African Palaeogene ancestry has been presumed by most primatologists. Until now, the oldest fossil records of New World monkeys have come from Salla, Bolivia, and date to approximately 26 million years ago, or the Late Oligocene epoch. Here we report the discovery of new primates from the ?Late Eocene epoch of Amazonian Peru, which extends the fossil record of primates in South America back approximately 10 million years. The new specimens are important for understanding the origin and early evolution of modern platyrrhine primates because they bear little resemblance to any extinct or living South American primate, but they do bear striking resemblances to Eocene African anthropoids, and our phylogenetic analysis suggests a relationship with African taxa. The discovery of these new primates brings the first appearance datum of caviomorph rodents and primates in South America back into close correspondence, but raises new questions about the timing and means of arrival of these two mammalian groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bond, Mariano -- Tejedor, Marcelo F -- Campbell, Kenneth E Jr -- Chornogubsky, Laura -- Novo, Nelson -- Goin, Francisco -- England -- Nature. 2015 Apr 23;520(7548):538-41. doi: 10.1038/nature14120. Epub 2015 Feb 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Division Paleontologia Vertebrados, Museo de Ciencias Naturales de La Plata, B1900FWA La Plata, Argentina. ; 1] CONICET, Centro Nacional Patagonico, Boulevard Almirante Brown 2915, 9120 Puerto Madryn, Chubut, Argentina [2] Facultad de Ciencias Naturales, Sede Trelew, Universidad Nacional de la Patagonia 'San Juan Bosco', 9100 Trelew, Chubut, Argentina. ; Vertebrate Zoology, Natural History Museum of Los Angeles County, Los Angeles, California 90007, USA. ; 1] CONICET, Seccion Paleontologia de Vertebrados, Museo Argentino de Ciencias Naturales 'Bernardino Rivadavia', Avenida Angel Gallardo 470, C1405DJR Buenos Aires, Argentina [2] Universidad Nacional de Lujan, Departamento de Ciencias Basicas. Ruta Nacional 5 and Avenida Constitucion, 6700 Lujan, Buenos Aires Province, Argentina. ; CONICET, Centro Nacional Patagonico, Boulevard Almirante Brown 2915, 9120 Puerto Madryn, Chubut, Argentina.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25652825" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/ethnology ; Animal Migration ; Animals ; *Fossils ; Microscopy, Electron, Scanning ; *Phylogeny ; Platyrrhini/anatomy & histology/*classification ; South America ; Time Factors
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  • 87
    Publication Date: 2015-07-15
    Description: Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. Here we resolve these inconsistencies and show that large eruptions in the tropics and high latitudes were primary drivers of interannual-to-decadal temperature variability in the Northern Hemisphere during the past 2,500 years. Our results are based on new records of atmospheric aerosol loading developed from high-resolution, multi-parameter measurements from an array of Greenland and Antarctic ice cores as well as distinctive age markers to constrain chronologies. Overall, cooling was proportional to the magnitude of volcanic forcing and persisted for up to ten years after some of the largest eruptive episodes. Our revised timescale more firmly implicates volcanic eruptions as catalysts in the major sixth-century pandemics, famines, and socioeconomic disruptions in Eurasia and Mesoamerica while allowing multi-millennium quantification of climate response to volcanic forcing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sigl, M -- Winstrup, M -- McConnell, J R -- Welten, K C -- Plunkett, G -- Ludlow, F -- Buntgen, U -- Caffee, M -- Chellman, N -- Dahl-Jensen, D -- Fischer, H -- Kipfstuhl, S -- Kostick, C -- Maselli, O J -- Mekhaldi, F -- Mulvaney, R -- Muscheler, R -- Pasteris, D R -- Pilcher, J R -- Salzer, M -- Schupbach, S -- Steffensen, J P -- Vinther, B M -- Woodruff, T E -- England -- Nature. 2015 Jul 30;523(7562):543-9. doi: 10.1038/nature14565. Epub 2015 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Desert Research Institute, Nevada System of Higher Education, Reno, Nevada 89512, USA. ; Department of Earth and Space Sciences, University of Washington, Seattle, Washington 98195, USA. ; Space Sciences Laboratory, University of California, Berkeley, California 94720, USA. ; School of Geography, Archaeology and Palaeoecology, Queen's University Belfast, Belfast BT7 1NN, UK. ; Yale Climate and Energy Institute, and Department of History, Yale University, New Haven, Connecticut 06511, USA. ; 1] Swiss Federal Research Institute WSL, 8903 Birmensdorf, Switzerland [2] Oeschger Centre for Climate Change Research, University of Bern, 3012 Bern, Switzerland [3] Global Change Research Centre AS CR, 60300 Brno, Czech Republic. ; 1] Department of Physics, Purdue University, West Lafayette, Indiana 47907, USA [2] Department of Earth, Atmospheric, and Planetary Sciences, Purdue University, West Lafayette, Indiana 47907, USA. ; Centre for Ice and Climate, Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark. ; 1] Oeschger Centre for Climate Change Research, University of Bern, 3012 Bern, Switzerland [2] Climate and Environmental Physics, University of Bern, 3012 Bern, Switzerland. ; Alfred-Wegener-Institut Helmholtz-Zentrum fur Polar- und Meeresforschung, 27570 Bremerhaven, Germany. ; Department of History, The University of Nottingham, Nottingham NG7 2RD, UK. ; Department of Geology, Quaternary Sciences, Lund University, 22362 Lund, Sweden. ; British Antarctic Survey, Natural Environment Research Council, Cambridge CB3 0ET, UK. ; The Laboratory of Tree-Ring Research, University of Arizona, Tucson, Arizona 85721, USA. ; Department of Physics, Purdue University, West Lafayette, Indiana 47907, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26153860" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/analysis ; Americas ; Antarctic Regions ; Atmosphere/chemistry ; Beryllium ; Carbon Radioisotopes ; *Climate ; Disasters/history ; Europe ; Greenland ; History, Ancient ; History, Medieval ; Ice/analysis ; Radioisotopes ; Radiometric Dating ; Seasons ; Sulfur ; *Temperature ; Time Factors ; Trees/anatomy & histology/growth & development ; Tropical Climate ; Volcanic Eruptions/*history
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  • 88
    Publication Date: 2015-05-23
    Description: Human evolutionary scholars have long supposed that the earliest stone tools were made by the genus Homo and that this technological development was directly linked to climate change and the spread of savannah grasslands. New fieldwork in West Turkana, Kenya, has identified evidence of much earlier hominin technological behaviour. We report the discovery of Lomekwi 3, a 3.3-million-year-old archaeological site where in situ stone artefacts occur in spatiotemporal association with Pliocene hominin fossils in a wooded palaeoenvironment. The Lomekwi 3 knappers, with a developing understanding of stone's fracture properties, combined core reduction with battering activities. Given the implications of the Lomekwi 3 assemblage for models aiming to converge environmental change, hominin evolution and technological origins, we propose for it the name 'Lomekwian', which predates the Oldowan by 700,000 years and marks a new beginning to the known archaeological record.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harmand, Sonia -- Lewis, Jason E -- Feibel, Craig S -- Lepre, Christopher J -- Prat, Sandrine -- Lenoble, Arnaud -- Boes, Xavier -- Quinn, Rhonda L -- Brenet, Michel -- Arroyo, Adrian -- Taylor, Nicholas -- Clement, Sophie -- Daver, Guillaume -- Brugal, Jean-Philip -- Leakey, Louise -- Mortlock, Richard A -- Wright, James D -- Lokorodi, Sammy -- Kirwa, Christopher -- Kent, Dennis V -- Roche, Helene -- England -- Nature. 2015 May 21;521(7552):310-5. doi: 10.1038/nature14464.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA [2] CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France [3] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA [2] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [3] Department of Anthropology and Center for Human Evolutionary Studies, Rutgers University, New Brunswick, New Jersey 08901, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Anthropology and Center for Human Evolutionary Studies, Rutgers University, New Brunswick, New Jersey 08901, USA [3] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [3] Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] CNRS, UPR 2147, Dynamique de l'Evolution Humaine, 44 rue de l'Amiral Mouchez, 75014 Paris, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] CNRS, UMR 5199 PACEA, Universite de Bordeaux, 33615 Pessac, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [3] Department of Sociology, Anthropology and Social Work, Seton Hall University, South Orange, New Jersey 07079, USA. ; 1] CNRS, UMR 5199 PACEA, Universite de Bordeaux, 33615 Pessac, France [2] Inrap, Centre Mixte de Recherche Archeologique, Domaine de Campagne, 24620 Campagne, France. ; CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France. ; 1] CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France [2] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Inrap, 34-36 avenue Paul-Vaillant Couturier, 93120 La Courneuve, France. ; IPHEP, Institut de Paleoprimatologie, Paleontologie Humaine: Evolution et Paleoenvironnements, CNRS, UMR 7262, Universite de Poitiers, Bat. B35 - TSA 51106, 6 rue Michel Brunet, 86073 Poitiers Cedex 9, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Aix-Marseille Universite, CNRS, MCC, UMR 7269, LAMPEA, 13094 Aix-en-Provence Cedex 2, France. ; Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA. ; Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA. ; West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] National Museums of Kenya, Department of Earth Sciences, Archaeology Section, P.O. Box 40658-00100 Ngara Rd, Nairobi, Kenya. ; 1] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [2] Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25993961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeology ; Biological Evolution ; Environment ; Fossils ; History, Ancient ; *Hominidae ; Kenya ; Paleontology ; Technology/history ; Time Factors ; *Tool Use Behavior
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  • 89
    Publication Date: 2015-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tollefson, Jeff -- Weiss, Kenneth R -- England -- Nature. 2015 Dec 17;528(7582):315-6. doi: 10.1038/528315a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26672532" target="_blank"〉PubMed〈/a〉
    Keywords: Congresses as Topic ; Developing Countries/economics ; Disasters/prevention & control ; Global Warming/*legislation & jurisprudence/*prevention & control ; Goals ; Government Regulation ; Greenhouse Effect/legislation & jurisprudence/prevention & control ; International Cooperation/*legislation & jurisprudence ; Negotiating ; Paris ; Renewable Energy ; Research Report ; Temperature ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 90
    Publication Date: 2015-06-23
    Description: Neanderthals are thought to have disappeared in Europe approximately 39,000-41,000 years ago but they have contributed 1-3% of the DNA of present-day people in Eurasia. Here we analyse DNA from a 37,000-42,000-year-old modern human from Pestera cu Oase, Romania. Although the specimen contains small amounts of human DNA, we use an enrichment strategy to isolate sites that are informative about its relationship to Neanderthals and present-day humans. We find that on the order of 6-9% of the genome of the Oase individual is derived from Neanderthals, more than any other modern human sequenced to date. Three chromosomal segments of Neanderthal ancestry are over 50 centimorgans in size, indicating that this individual had a Neanderthal ancestor as recently as four to six generations back. However, the Oase individual does not share more alleles with later Europeans than with East Asians, suggesting that the Oase population did not contribute substantially to later humans in Europe.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537386/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537386/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fu, Qiaomei -- Hajdinjak, Mateja -- Moldovan, Oana Teodora -- Constantin, Silviu -- Mallick, Swapan -- Skoglund, Pontus -- Patterson, Nick -- Rohland, Nadin -- Lazaridis, Iosif -- Nickel, Birgit -- Viola, Bence -- Prufer, Kay -- Meyer, Matthias -- Kelso, Janet -- Reich, David -- Paabo, Svante -- GM100233/GM/NIGMS NIH HHS/ -- R01 GM100233/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2015 Aug 13;524(7564):216-9. doi: 10.1038/nature14558. Epub 2015 Jun 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, IVPP, CAS, Beijing 100044, China [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany. ; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany. ; Emil Racovita" Institute of Speleology, Cluj Branch, 400006 Cluj, Romania. ; Emil Racovita" Institute of Speleology, Department of Geospeleology and Paleontology, 010986 Bucharest 12, Romania. ; 1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [3] Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany. ; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA. ; 1] Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany [2] Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany [3] Department of Anthropology, University of Toronto, Toronto, Ontario, M5S 2S2, Canada. ; 1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26098372" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Far East ; *Fossils ; Genome, Human/genetics ; Humans ; Hybridization, Genetic/*genetics ; Indians, North American/genetics ; Male ; Neanderthals/*genetics ; *Phylogeny ; Romania ; Sequence Analysis, DNA ; Time Factors
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  • 91
    Publication Date: 2015-03-06
    Description: Over 20% of Earth's terrestrial surface is underlain by permafrost with vast stores of carbon that, once thawed, may represent the largest future transfer of carbon from the biosphere to the atmosphere. This process is largely dependent on microbial responses, but we know little about microbial activity in intact, let alone in thawing, permafrost. Molecular approaches have recently revealed the identities and functional gene composition of microorganisms in some permafrost soils and a rapid shift in functional gene composition during short-term thaw experiments. However, the fate of permafrost carbon depends on climatic, hydrological and microbial responses to thaw at decadal scales. Here we use the combination of several molecular 'omics' approaches to determine the phylogenetic composition of the microbial communities, including several draft genomes of novel species, their functional potential and activity in soils representing different states of thaw: intact permafrost, seasonally thawed active layer and thermokarst bog. The multi-omics strategy reveals a good correlation of process rates to omics data for dominant processes, such as methanogenesis in the bog, as well as novel survival strategies for potentially active microbes in permafrost.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hultman, Jenni -- Waldrop, Mark P -- Mackelprang, Rachel -- David, Maude M -- McFarland, Jack -- Blazewicz, Steven J -- Harden, Jennifer -- Turetsky, Merritt R -- McGuire, A David -- Shah, Manesh B -- VerBerkmoes, Nathan C -- Lee, Lang Ho -- Mavrommatis, Kostas -- Jansson, Janet K -- England -- Nature. 2015 May 14;521(7551):208-12. doi: 10.1038/nature14238. Epub 2015 Mar 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Earth Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California, 94720, USA. ; US Geological Survey, 345 Middlefield Road, Menlo Park, California 94025, USA. ; 1] Biology Department, 18111 Nordhoff Street, California State University Northridge, Northridge, California 91330, USA [2] US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California 94598, USA. ; Department of Integrative Biology, 50 Stone Road East, University of Guelph, Guelph, Ontario N1G 2W1, Canada. ; US Geological Survey, Alaska Cooperative Fish and Wildlife Research Unit, 211A Irving I Building, University of Alaska Fairbanks, Fairbanks, Alaska 99775, USA. ; Chemical Sciences Division, One Bethel Valley Road, Building 1059, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6420, USA. ; Graduate School of Genome Science and Technology, University of Tennessee and Oak Ridge National Laboratory, 2510 River Drive, Knoxville, Tennessee 37996, USA. ; US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California 94598, USA. ; 1] Earth Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California, 94720, USA [2] US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, California 94598, USA [3] Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, Berkeley, California 94720, USA [4] Center for Permafrost Research (CENPERM), Department of Biology, Universitetsparken 15, University of Copenhagen, Copenhagen, DK-2100 Copenhagen, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25739499" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Atmosphere/chemistry ; Carbon Cycle ; Climate ; Denitrification ; Freezing ; Genome, Bacterial/*genetics ; Iron/metabolism ; Metagenome/*genetics ; Methane/metabolism ; Microbiota/genetics/*physiology ; Nitrates/metabolism ; Nitrogen/metabolism ; Oxidation-Reduction ; Permafrost/*microbiology ; Phylogeny ; Seasons ; *Soil Microbiology ; Sulfur/metabolism ; Time Factors ; *Wetlands
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  • 92
    Publication Date: 2015-06-05
    Description: During bacterial growth, a cell approximately doubles in size before division, after which it splits into two daughter cells. This process is subjected to the inherent perturbations of cellular noise and thus requires regulation for cell-size homeostasis. The mechanisms underlying the control and dynamics of cell size remain poorly understood owing to the difficulty in sizing individual bacteria over long periods of time in a high-throughput manner. Here we measure and analyse long-term, single-cell growth and division across different Escherichia coli strains and growth conditions. We show that a subset of cells in a population exhibit transient oscillations in cell size with periods that stretch across several (more than ten) generations. Our analysis reveals that a simple law governing cell-size control-a noisy linear map-explains the origins of these cell-size oscillations across all strains. This noisy linear map implements a negative feedback on cell-size control: a cell with a larger initial size tends to divide earlier, whereas one with a smaller initial size tends to divide later. Combining simulations of cell growth and division with experimental data, we demonstrate that this noisy linear map generates transient oscillations, not just in cell size, but also in constitutive gene expression. Our work provides new insights into the dynamics of bacterial cell-size regulation with implications for the physiological processes involved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanouchi, Yu -- Pai, Anand -- Park, Heungwon -- Huang, Shuqiang -- Stamatov, Rumen -- Buchler, Nicolas E -- You, Lingchong -- DP2 OD008654/OD/NIH HHS/ -- DP2 OD008654-01/OD/NIH HHS/ -- R01GM098642/GM/NIGMS NIH HHS/ -- R01GM110494/GM/NIGMS NIH HHS/ -- England -- Nature. 2015 Jul 16;523(7560):357-60. doi: 10.1038/nature14562. Epub 2015 Jun 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. ; 1] Department of Physics, Duke University, Durham, North Carolina 27708, USA [2] Department of Biology, Duke University, Durham, North Carolina 27708, USA. ; Computational Biology and Bioinformatics, Duke University, Durham, North Carolina 27708, USA. ; 1] Department of Physics, Duke University, Durham, North Carolina 27708, USA [2] Department of Biology, Duke University, Durham, North Carolina 27708, USA [3] Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA. ; 1] Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA [2] Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26040722" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Division/genetics ; Cell Size ; Computer Simulation ; Escherichia coli/classification/*cytology/*genetics/growth & development ; *Feedback, Physiological ; *Gene Expression Regulation, Bacterial ; Homeostasis/genetics ; Models, Biological ; Single-Cell Analysis ; Time Factors
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  • 93
    Publication Date: 2015-12-04
    Description: Most human breast cancers have diversified genomically and biologically by the time they become clinically evident. Early events involved in their genesis and the cellular context in which these events occur have thus been difficult to characterize. Here we present the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice. DNA barcoding of the initial cells revealed a dramatic change in the numbers and sizes of clones generated from them within 2 weeks, and the first appearance of many 'new' clones in tumours passaged into secondary recipients. Both primary and secondary tumours were phenotypically heterogeneous and primary tumours were categorized transcriptionally as 'normal-like'. This system challenges previous concepts that carcinogenesis in normal human epithelia is necessarily a slow process requiring the acquisition of multiple driver mutations. It also presents the first description of initial events that accompany the genesis and evolution of malignant human mammary cell populations, thereby contributing new understanding of the rapidity with which heterogeneity in their properties can develop.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nguyen, Long V -- Pellacani, Davide -- Lefort, Sylvain -- Kannan, Nagarajan -- Osako, Tomo -- Makarem, Maisam -- Cox, Claire L -- Kennedy, William -- Beer, Philip -- Carles, Annaick -- Moksa, Michelle -- Bilenky, Misha -- Balani, Sneha -- Babovic, Sonja -- Sun, Ivan -- Rosin, Miriam -- Aparicio, Samuel -- Hirst, Martin -- Eaves, Connie J -- Canadian Institutes of Health Research/Canada -- England -- Nature. 2015 Dec 10;528(7581):267-71. doi: 10.1038/nature15742. Epub 2015 Dec 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Terry Fox Laboratory, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. ; Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 2B5, Canada. ; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada. ; Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. ; Centre for High-Throughput Biology, Department of Microbiology &Immunology, University of British Columbia, 2125 East Mall, Vancouver, British Columbia V6T 1Z4, Canada. ; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. ; Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada. ; Cancer Control Unit, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26633636" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/genetics/*physiopathology ; Carcinoma, Ductal, Breast/genetics/*physiopathology ; Cell Lineage/genetics ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA Barcoding, Taxonomic ; Female ; Gene Expression Profiling ; Heterografts ; Humans ; Lentivirus/genetics ; Mammary Glands, Human/cytology/*physiopathology ; Mice ; Mice, Inbred Strains ; Mice, SCID ; Proto-Oncogene Proteins/genetics ; Time Factors ; Transduction, Genetic ; ras Proteins/genetics
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  • 94
    Publication Date: 2015-08-20
    Description: Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ku, Chuan -- Nelson-Sathi, Shijulal -- Roettger, Mayo -- Sousa, Filipa L -- Lockhart, Peter J -- Bryant, David -- Hazkani-Covo, Einat -- McInerney, James O -- Landan, Giddy -- Martin, William F -- England -- Nature. 2015 Aug 27;524(7566):427-32. doi: 10.1038/nature14963. Epub 2015 Aug 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Evolution, Heinrich-Heine University, 40225 Dusseldorf, Germany. ; Institute of Fundamental Sciences, Massey University, Palmerston North 4474, New Zealand. ; Department of Mathematics and Statistics, University of Otago, Dunedin 9054, New Zealand. ; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana 43107, Israel. ; Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland. ; Michael Smith Building, The University of Manchester, Oxford Rd, Manchester M13 9PL, UK. ; Genomic Microbiology Group, Institute of Microbiology, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany. ; Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26287458" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/genetics ; Bacteria/genetics ; Cluster Analysis ; Eukaryota/classification/*genetics ; Eukaryotic Cells/metabolism ; *Evolution, Molecular ; Gene Transfer, Horizontal/genetics ; Genome/genetics ; Mitochondria/genetics ; *Models, Genetic ; Organelles/*genetics ; Phylogeny ; Plastids/genetics ; Prokaryotic Cells/metabolism ; Proteome/genetics ; Symbiosis/*genetics ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 95
    Publication Date: 2015-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iovanna, Juan -- England -- Nature. 2015 Feb 5;518(7537):35. doi: 10.1038/518035b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM UMR1068, CNRS UMR7258, Aix-Marseille University and Institute Paoli-Calmettes, Marseille, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25652985" target="_blank"〉PubMed〈/a〉
    Keywords: Contract Services/economics/*legislation & jurisprudence ; Contracts/legislation & jurisprudence ; Employment/economics/*legislation & jurisprudence ; France ; Laboratories/*manpower ; Laboratory Personnel/*economics ; Research Personnel/*economics ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 96
    Publication Date: 2015-07-16
    Description: Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of approximately 50-80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kropff, Emilio -- Carmichael, James E -- Moser, May-Britt -- Moser, Edvard I -- England -- Nature. 2015 Jul 23;523(7561):419-24. doi: 10.1038/nature14622. Epub 2015 Jul 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7491 Trondheim, Norway [2] Leloir Institute, IIBBA - CONICET, Buenos Aires, C1405BWE, Argentina. ; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7491 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26176924" target="_blank"〉PubMed〈/a〉
    Keywords: Acceleration ; Action Potentials/physiology ; Animals ; Entorhinal Cortex/*cytology/*physiology ; Environment ; Male ; Models, Neurological ; Neurons/*physiology ; Rats ; Rats, Long-Evans ; Running/*physiology/*psychology ; Time Factors
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  • 97
    Publication Date: 2015-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartgerink, Chris H J -- England -- Nature. 2015 Jun 25;522(7557):419. doi: 10.1038/522419d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tilburg University, the Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26108842" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Language ; *Research Report ; Scientific Misconduct/*legislation & jurisprudence ; Sweden ; Time Factors ; *Translations
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  • 98
    Publication Date: 2015-01-09
    Description: Policy makers have generally agreed that the average global temperature rise caused by greenhouse gas emissions should not exceed 2 degrees C above the average global temperature of pre-industrial times. It has been estimated that to have at least a 50 per cent chance of keeping warming below 2 degrees C throughout the twenty-first century, the cumulative carbon emissions between 2011 and 2050 need to be limited to around 1,100 gigatonnes of carbon dioxide (Gt CO2). However, the greenhouse gas emissions contained in present estimates of global fossil fuel reserves are around three times higher than this, and so the unabated use of all current fossil fuel reserves is incompatible with a warming limit of 2 degrees C. Here we use a single integrated assessment model that contains estimates of the quantities, locations and nature of the world's oil, gas and coal reserves and resources, and which is shown to be consistent with a wide variety of modelling approaches with different assumptions, to explore the implications of this emissions limit for fossil fuel production in different regions. Our results suggest that, globally, a third of oil reserves, half of gas reserves and over 80 per cent of current coal reserves should remain unused from 2010 to 2050 in order to meet the target of 2 degrees C. We show that development of resources in the Arctic and any increase in unconventional oil production are incommensurate with efforts to limit average global warming to 2 degrees C. Our results show that policy makers' instincts to exploit rapidly and completely their territorial fossil fuels are, in aggregate, inconsistent with their commitments to this temperature limit. Implementation of this policy commitment would also render unnecessary continued substantial expenditure on fossil fuel exploration, because any new discoveries could not lead to increased aggregate production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGlade, Christophe -- Ekins, Paul -- England -- Nature. 2015 Jan 8;517(7533):187-90. doi: 10.1038/nature14016.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University College London (UCL), Institute for Sustainable Resources, Central House, 14 Upper Woburn Place, London WC1H 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25567285" target="_blank"〉PubMed〈/a〉
    Keywords: Arctic Regions ; Atmosphere/chemistry ; Carbon Dioxide/analysis ; Coal/economics/supply & distribution/utilization ; Databases, Factual ; Fossil Fuels/economics/*supply & distribution/*utilization ; *Geography ; Global Warming/*prevention & control/*statistics & numerical data ; Greenhouse Effect/prevention & control/statistics & numerical data ; Models, Theoretical ; Oil and Gas Fields ; Time Factors
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  • 99
    Publication Date: 2015-01-22
    Description: Neurobiological models of long-term memory propose a mechanism by which initially weak memories are strengthened through subsequent activation that engages common neural pathways minutes to hours later. This synaptic tag-and-capture model has been hypothesized to explain how inconsequential information is selectively consolidated following salient experiences. Behavioural evidence for tag-and-capture is provided by rodent studies in which weak early memories are strengthened by future behavioural training. Whether a process of behavioural tagging occurs in humans to transform weak episodic memories into stable long-term memories is unknown. Here we show, in humans, that information is selectively consolidated if conceptually related information, putatively represented in a common neural substrate, is made salient through an emotional learning experience. Memory for neutral objects was selectively enhanced if other objects from the same category were paired with shock. Retroactive enhancements as a result of emotional learning were observed following a period of consolidation, but were not observed in an immediate memory test or for items strongly encoded before fear conditioning. These findings provide new evidence for a generalized retroactive memory enhancement, whereby inconsequential information can be retroactively credited as relevant, and therefore selectively remembered, if conceptually related information acquires salience in the future.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432479/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432479/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunsmoor, Joseph E -- Murty, Vishnu P -- Davachi, Lila -- Phelps, Elizabeth A -- F31 DA036361/DA/NIDA NIH HHS/ -- R01 MH047692/MH/NIMH NIH HHS/ -- R01 MH074692/MH/NIMH NIH HHS/ -- R01 MH097085/MH/NIMH NIH HHS/ -- T32 MH019524/MH/NIMH NIH HHS/ -- England -- Nature. 2015 Apr 16;520(7547):345-8. doi: 10.1038/nature14106. Epub 2015 Jan 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology and Center for Neural Sciences, New York University, New York, New York 10003, USA. ; 1] Department of Psychology and Center for Neural Sciences, New York University, New York, New York 10003, USA [2] Nathan Kline Institute, Orangeburg, New York 10962, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25607357" target="_blank"〉PubMed〈/a〉
    Keywords: Conditioning, Classical/physiology ; Emotions/*physiology ; Fear/physiology/psychology ; Female ; Humans ; Male ; Memory, Episodic ; Memory, Long-Term/*physiology ; Memory, Short-Term/*physiology ; Mental Recall/physiology ; Models, Neurological ; Neural Pathways ; Photic Stimulation ; Recognition (Psychology)/physiology ; Time Factors ; Young Adult
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  • 100
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    Nature Publishing Group (NPG)
    Publication Date: 2015-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Powell, Kendall -- England -- Nature. 2015 Apr 9;520(7546):144-7. doi: 10.1038/520144a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25855437" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Career Mobility ; Education, Graduate/*statistics & numerical data/*trends ; Employment/*statistics & numerical data ; Laboratories/manpower/organization & administration ; Research Personnel/economics/*education/*statistics & numerical data ; Salaries and Fringe Benefits/economics/statistics & numerical data ; Time Factors
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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