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  • 1
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    EWS regulates mitochondria homeostasis [Cell Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-05-13
    Description: EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations. Physiologically, EWS has diverse and essential roles in various organ development and cellular processes. In this study, we uncovered a new role of EWS in mitochondrial homeostasis and energy...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉The instructive capabilities of extracellular matrix–inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment. We previously demonstrated that nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffolds efficiently induced osteoprogenitor differentiation and bone healing. In this work, we combined adenovirus-mediated delivery of osteoprotegerin (AdOPG), an endogenous anti-osteoclastogenic decoy receptor, in primary human mesenchymal stem cells (hMSCs) with MC-GAG to understand the role of osteoclast inactivation in augmentation of bone regeneration. Simultaneous differentiation of osteoprogenitors on MC-GAG and osteoclast progenitors resulted in bidirectional positive regulation. AdOPG expression did not affect osteogenic differentiation alone. In the presence of both cell types, AdOPG-transduced hMSCs on MC-GAG diminished osteoclast-mediated resorption in direct contact; however, osteoclast-mediated augmentation of osteogenic differentiation was unaffected. Thus, the combination of OPG with MC-GAG may represent a method for uncoupling osteogenic and osteoclastogenic differentiation to augment bone regeneration.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Taste-independent detection of the caloric content of sugar in Drosophila [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-07-13
    Description: Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of food deprivation and metabolic needs in the selection of appropriate food is poorly understood. Here, we show that the fruit fly, Drosophila melanogaster, selects calorie-rich foods following prolonged food deprivation in the absence of taste-receptor signaling. Flies mutant for the sugar receptors Gr5a and Gr64a cannot detect the taste of sugar, but still consumed sugar over plain agar after 15 h of starvation. Similarly, pox-neuro mutants that are insensitive to the taste of sugar preferentially consumed sugar over plain agar upon starvation. Moreover, when given a choice between metabolizable sugar (sucrose or d-glucose) and nonmetabolizable (zero-calorie) sugar (sucralose or l-glucose), starved Gr5a; Gr64a double mutants preferred metabolizable sugars. These findings suggest the existence of a taste-independent metabolic sensor that functions in food selection. The preference for calorie-rich food correlates with a decrease in the two main hemolymph sugars, trehalose and glucose, and in glycogen stores, indicating that this sensor is triggered when the internal energy sources are depleted. Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-23
    Description: The current outbreak of Ebola virus in West Africa is unprecedented, causing more cases and fatalities than all previous outbreaks combined, and has yet to be controlled. Several post-exposure interventions have been employed under compassionate use to treat patients repatriated to Europe and the United States. However, the in vivo efficacy of these interventions against the new outbreak strain of Ebola virus is unknown. Here we show that lipid-nanoparticle-encapsulated short interfering RNAs (siRNAs) rapidly adapted to target the Makona outbreak strain of Ebola virus are able to protect 100% of rhesus monkeys against lethal challenge when treatment was initiated at 3 days after exposure while animals were viraemic and clinically ill. Although all infected animals showed evidence of advanced disease including abnormal haematology, blood chemistry and coagulopathy, siRNA-treated animals had milder clinical features and fully recovered, while the untreated control animals succumbed to the disease. These results represent the first, to our knowledge, successful demonstration of therapeutic anti-Ebola virus efficacy against the new outbreak strain in nonhuman primates and highlight the rapid development of lipid-nanoparticle-delivered siRNA as a countermeasure against this highly lethal human disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467030/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467030/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thi, Emily P -- Mire, Chad E -- Lee, Amy C H -- Geisbert, Joan B -- Zhou, Joy Z -- Agans, Krystle N -- Snead, Nicholas M -- Deer, Daniel J -- Barnard, Trisha R -- Fenton, Karla A -- MacLachlan, Ian -- Geisbert, Thomas W -- U19 AI109711/AI/NIAID NIH HHS/ -- U19AI109711/AI/NIAID NIH HHS/ -- England -- Nature. 2015 May 21;521(7552):362-5. doi: 10.1038/nature14442. Epub 2015 Apr 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tekmira Pharmaceuticals, Burnaby, British Columbia V5J 5J8, Canada. ; 1] Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas 77550, USA [2] Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77550, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25901685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Disease Models, Animal ; Ebolavirus/classification/*drug effects/*genetics ; Female ; Hemorrhagic Fever, Ebola/pathology/prevention & control/*therapy/*virology ; Humans ; Macaca mulatta/virology ; Male ; Nanoparticles/*administration & dosage ; RNA, Small Interfering/*administration & dosage/pharmacology/*therapeutic use ; Survival Analysis ; Time Factors ; Treatment Outcome ; Viral Load/drug effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    The distribution of dark and luminous matter in the unique galaxy cluster merger Abell 2146 (2016)
    Oxford University Press
    Details
    Publication Date: 2016-04-23
    Description: Abell 2146 ( z  = 0.232) consists of two galaxy clusters undergoing a major merger. The system was discovered in previous work, where two large shock fronts were detected using the Chandra X-ray Observatory , consistent with a merger close to the plane of the sky, caught soon after first core passage. A weak gravitational lensing analysis of the total gravitating mass in the system, using the distorted shapes of distant galaxies seen with Advanced Camera for Surveys - Wide Field Channel on Hubble Space Telescope , is presented. The highest peak in the reconstruction of the projected mass is centred on the brightest cluster galaxy (BCG) in Abell 2146-A. The mass associated with Abell 2146-B is more extended. Bootstrapped noise mass reconstructions show the mass peak in Abell 2146-A to be consistently centred on the BCG. Previous work showed that BCG-A appears to lag behind an X-ray cool core; although the peak of the mass reconstruction is centred on the BCG, it is also consistent with the X-ray peak given the resolution of the weak lensing mass map. The best-fitting mass model with two components centred on the BCGs yields M 200 = 1.1 $^{+0.3}_{-0.4}$ x 10 15 and 3 $^{+1}_{-2}$ x 10 14  M for Abell 2146-A and Abell 2146-B, respectively, assuming a mass concentration parameter of c = 3.5 for each cluster. From the weak lensing analysis, Abell 2146-A is the primary halo component, and the origin of the apparent discrepancy with the X-ray analysis where Abell 2146-B is the primary halo is being assessed using simulations of the merger.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    MST1 mediates SOD1(G93A)-induced neurotoxicity [Neuroscience] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-07-17
    Description: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Dominant mutations in the gene for superoxide dismutase 1 (SOD1) give rise to familial ALS by an unknown mechanism. Here we show that genetic deficiency of mammalian sterile 20-like kinase 1 (MST1) delays disease onset...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Engineering large Stark shifts for control of individual clock state qubits (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-10-11
    Description: Author(s): A. C. Lee, J. Smith, P. Richerme, B. Neyenhuis, P. W. Hess, J. Zhang, and C. Monroe In quantum information science, the external control of qubits must be balanced with the extreme isolation of the qubits from the environment. Atomic qubit systems typically mitigate this balance through the use of gated laser fields that can create superpositions and entanglement between qubits. He… [Phys. Rev. A 94, 042308] Published Fri Oct 07, 2016
    Keywords: Quantum information
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of different molecular forms of alkaline phosphatase in the hepatopancreas from the shrimp Penaeus monodon (Crustacea: Decapoda)
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 99 (1991), S. 845-850 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(91)90152-4
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  • 9
    Electronic Resource
    Electronic Resource
    INTERPRETATION OF VLF-EM IN-PHASE DATA USING CURRENT DENSITY PSEUDOSECTIONS (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 39 (1991), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The interpretation of VLF-EM surveys in terms of buried conductors can be assisted by the application of a linear filter to the observed in-phase component of the vertical magnetic field. One such scheme is examined critically by using the calculated response from a variety of synthetic models to compute theoretical current density pseudosections.The results confirm that this filter technique provides a useful complementary tool for studying the third (i.e. depth) dimension. For single, steeply dipping plates (〉 45°) diagnostic information may be derived concerning the depth, size, lateral location, and direction of dip, since the current density maxima seems always to occur within the conductor or at least within one data interval.However, there are some limitations which do not appear to be widely recognized. For single plates the angle of dip cannot be resolved by the current density transformation. Pattern distortions can occur where targets are in close proximity, where the cross-sectional form of the conductor is complex or where the dip is shallow (〈 45°). In these latter cases the current density maxima may not occur within the conductive structure and therefore cannot be used to infer depth of burial and/or conductor shape with the same degree of confidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1991.tb00328.x
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  • 10
    Electronic Resource
    Electronic Resource
    Paired electro-oxidation Part II: Production of anthraquinone in an undivided cell (1993)
    Springer
    Journal of applied electrochemistry 23 (1993), S. 1259-1262 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Oxidation of anthracene to anthraquinone by the anodically generated oxidant V5+ and both V5+ and · OH free radicals generated cathodically was carried out simultaneously in an undivided cell. Both the yield and selectivity of anthraquinone by paired electro-oxidation are higher than that by anodic oxidation only. The maximum total current efficiency for anthraquinone production in the paired electro-oxidation was 151%. A process for anthraquinone production using an undivided cell electrolyser is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234809
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