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  • 1
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    Bisphosphonates inhibit human EGFRs [Medical Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-17
    Description: Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells. Using connectivity mapping, we identified human epidermal growth...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Geosciences, Vol. 9, Pages 358: Superposed Sedimentary and Tectonic Block-In-Matrix Fabrics in a Subducted Serpentinite Mélange (High-Pressure Zermatt Saas Ophiolite, Western Alps) (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: The primary stratigraphic fabric of a chaotic rock unit in the Zermatt Saas ophiolite of the Western Alps was reworked by a polyphase Alpine tectonic deformation. Multiscalar structural criteria demonstrate that this unit was deformed by two ductile subduction-related phases followed by brittle-ductile then brittle deformation. Deformation partitioning operated at various scales, leaving relatively unstrained rock domains preserving internal texture, organization, and composition. During subduction, ductile deformation involved stretching, boudinage, and simultaneous folding of the primary stratigraphic succession. This deformation is particularly well-documented in alternating layers showing contrasting deformation style, such as carbonate-rich rocks and turbiditic serpentinite metasandstones. During collision and exhumation, deformation enhanced the boudinaged horizons and blocks, giving rise to spherical to lozenge-shaped blocks embedded in a carbonate-rich matrix. Structural criteria allow the recognition of two main domains within the chaotic rock unit, one attributable to original broken formations reflecting turbiditic sedimentation, the other ascribable to an original sedimentary mélange. The envisaged geodynamic setting for the formation of the protoliths is the Jurassic Ligurian-Piedmont ocean basin floored by mostly serpentinized peridotites, intensely tectonized by extensional faults that triggered mass transport processes and turbiditic sedimentation.
    Electronic ISSN: 2076-3263
    Topics: Geosciences
    Published by MDPI
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  • 3
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    QED radiative corrections to low-energy Møller and Bhabha scattering (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-08-11
    Description: Author(s): Charles S. Epstein and Richard G. Milner We present a treatment of the next-to-leading-order radiative corrections to unpolarized Møller and Bhabha scattering without resorting to ultrarelativistic approximations. We extend existing soft-photon radiative corrections with new hard-photon bremsstrahlung calculations so that the effect of pho… [Phys. Rev. D 94, 033004] Published Wed Aug 10, 2016
    Keywords: Electroweak Interactions
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-11
    Description: The majority (〉99%) of microorganisms from the environment resist cultivation in the laboratory. Ribosomal RNA analysis suggests that uncultivated organisms are found in nearly every prokaryotic group, and several divisions have no known cultivable representatives. We designed a diffusion chamber that allowed the growth of previously uncultivated microorganisms in a simulated natural environment. Colonies of representative marine organisms were isolated in pure culture. These isolates did not grow on artificial media alone but formed colonies in the presence of other microorganisms. This observation may help explain the nature of microbial uncultivability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaeberlein, T -- Lewis, K -- Epstein, S S -- New York, N.Y. -- Science. 2002 May 10;296(5570):1127-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004133" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/classification/cytology/*growth & development/*isolation & purification ; *Bacteriological Techniques ; Colony Count, Microbial ; Culture Media ; DNA, Bacterial/analysis/genetics ; DNA, Ribosomal/analysis/genetics ; Diffusion Chambers, Culture ; Geologic Sediments/*microbiology ; Molecular Sequence Data ; RNA, Ribosomal, 16S/genetics ; *Seawater ; Silicon Dioxide
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Microbial awakenings (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, Slava S -- England -- Nature. 2009 Feb 26;457(7233):1083. doi: 10.1038/4571083a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA. s.epstein@neu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19242455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial/physiology ; *Microbial Viability/drug effects ; *Microbiology ; *Models, Biological ; Stochastic Processes ; Tuberculosis/microbiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Protection of C. elegans from anoxia by HYL-2 ceramide synthase (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of C. elegans to anoxia. C. elegans has two ceramide synthases, hyl-1 and hyl-2, that participate in ceramide biogenesis and affect its ability to survive anoxic conditions. In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. These data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Menuz, Vincent -- Howell, Kate S -- Gentina, Sebastien -- Epstein, Sharon -- Riezman, Isabelle -- Fornallaz-Mulhauser, Monique -- Hengartner, Michael O -- Gomez, Marie -- Riezman, Howard -- Martinou, Jean-Claude -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):381-4. doi: 10.1126/science.1168532.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372430" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Caenorhabditis elegans/cytology/genetics/*physiology ; Caenorhabditis elegans Proteins/*genetics/*metabolism ; *Cell Hypoxia ; Ceramides/biosynthesis/*physiology ; Gene Deletion ; Genes, Helminth ; Mutation ; Oxidoreductases/*genetics/*metabolism ; Oxygen/*physiology ; Receptor, Insulin/genetics/metabolism ; Saccharomyces cerevisiae/genetics/growth & development/physiology ; Sphingomyelins/biosynthesis/physiology ; Substrate Specificity ; Transformation, Genetic ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Water on Mars: Clues from Deuterium/Hydrogen and Water Contents of Hydrous Phases in SNC Meteorites (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-01
    Description: Ion microprobe studies of hydrous amphibole, biotite, and apatite in shergottite-nakhlite-chassignite (SNC) meteorites, probable igneous rocks from Mars, indicate high deuterium/hydrogen (D/H) ratios relative to terrestrial values. The amphiboles contain roughly one-tentn as much water as expected, suggesting that SNC magmas were less hydrous than previously proposed. The high but variable D/H values of these minerals are best explained by postcrystallization D enrichment of initially D-poor phases by martian crustal fluids with near atmospheric D/H (about five times the terrestrial value). These igneous phases do not directly reflect the D/H ratios of martian "magmatic" water but provide evidence for a D-enriched martian crustal water reservoir.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, L L -- Hutcheon, I D -- Epstein, S -- Stolper, E M -- New York, N.Y. -- Science. 1994 Jul 1;265(5168):86-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17774694" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Climatic implications of an 8000-year hydrogen isotope time series from bristlecone pine trees (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-08-19
    Description: Tree rings from three dendrochronologically dated bristlecone pines were analyzed for stable hydrogen isotopic composition. These trees give a continuous time series from 8000 years ago to the present that indicates the presence of a postglacial climate optimum 6800 years ago and a continuous cooling since then. The qualitative agreement between this record and records from other sources, such as ice cores, pollen, and treeline fluctuations, indicates that these climate changes were global. This record can serve as a reference for other climate indicators throughout the past 8000 years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, X -- Epstein, S -- New York, N.Y. -- Science. 1994 Aug 19;265(5175):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17832901" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Comment on "Computational improvements reveal great bacterial diversity and high metal toxicity in soil" (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-08-19
    Description: Gans et al. (Reports, 26 August 2005, p. 1387) provided an estimate of soil bacterial species richness two orders of magnitude greater than previously reported values. Using a re-derived mathematical model, we reanalyzed the data and found that the statistical error exceeds the estimate by a factor of 26. We also note two potential sources of error in the experimental data collection and measurement procedures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunge, John -- Epstein, Slava S -- Peterson, Daniel G -- New York, N.Y. -- Science. 2006 Aug 18;313(5789):918; author reply 918.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Statistical Science, Cornell University, Ithaca, NY 14853, USA. jab18@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16917045" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/genetics/*growth & development ; *Biodiversity ; DNA, Bacterial/*analysis ; Kinetics ; Mathematics ; Metals, Heavy/analysis/*toxicity ; Models, Biological ; Nucleic Acid Renaturation ; *Soil Microbiology ; Soil Pollutants/analysis/*toxicity ; Statistics as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Carbon isotopic evidence for different feeding patterns in two hyrax species occupying the same habitat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: The carbon-13/carbon-12 ratios of the carbonate and collagen fractions of bone of the sympatric hyrax species Procavia johnstoni and Heterohyrax brucei indicate that the former obtains most of its diet by grazing while the latter is primarily a browser. The carbon-13/carbon-12 ratios of these fractions in fossil bone will record information about diet if they have not been altered during diagenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deniro, M J -- Epstein, S -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):906-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17729570" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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