ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • United States  (157)
  • *Ecosystem  (104)
  • Mutation  (71)
  • Crystallography, X-Ray  (46)
  • American Association for the Advancement of Science (AAAS)  (365)
  • American Association of Petroleum Geologists (AAPG)
  • Institute of Electrical and Electronics Engineers (IEEE)
  • Open Book Publishers
  • Springer
  • Sächsisches Landesamt für Umwelt, Landwirtschaft und Geologie
  • Wiley-Blackwell - SSH
  • 2010-2014  (365)
  • 2011  (365)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (365)
  • American Association of Petroleum Geologists (AAPG)
  • Institute of Electrical and Electronics Engineers (IEEE)
  • Open Book Publishers
  • Springer
  • +
Years
  • 2010-2014  (365)
Year
  • 1
    Publication Date: 2011-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1731. doi: 10.1126/science.330.6012.1731.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205643" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/*education ; *Biological Evolution ; Employment/*legislation & jurisprudence ; Kentucky ; *Religion and Science ; United States ; Universities/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muddiman, David C -- New York, N.Y. -- Science. 2011 Jan 14;331(6014):160. doi: 10.1126/science.1201766.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA. dcmuddim@ncsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233376" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry/*history ; History, 20th Century ; History, 21st Century ; Nobel Prize ; Spectrometry, Mass, Electrospray Ionization/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2011-07-19
    Description: Until recently, large apex consumers were ubiquitous across the globe and had been for millions of years. The loss of these animals may be humankind's most pervasive influence on nature. Although such losses are widely viewed as an ethical and aesthetic problem, recent research reveals extensive cascading effects of their disappearance in marine, terrestrial, and freshwater ecosystems worldwide. This empirical work supports long-standing theory about the role of top-down forcing in ecosystems but also highlights the unanticipated impacts of trophic cascades on processes as diverse as the dynamics of disease, wildfire, carbon sequestration, invasive species, and biogeochemical cycles. These findings emphasize the urgent need for interdisciplinary research to forecast the effects of trophic downgrading on process, function, and resilience in global ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Estes, James A -- Terborgh, John -- Brashares, Justin S -- Power, Mary E -- Berger, Joel -- Bond, William J -- Carpenter, Stephen R -- Essington, Timothy E -- Holt, Robert D -- Jackson, Jeremy B C -- Marquis, Robert J -- Oksanen, Lauri -- Oksanen, Tarja -- Paine, Robert T -- Pikitch, Ellen K -- Ripple, William J -- Sandin, Stuart A -- Scheffer, Marten -- Schoener, Thomas W -- Shurin, Jonathan B -- Sinclair, Anthony R E -- Soule, Michael E -- Virtanen, Risto -- Wardle, David A -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):301-6. doi: 10.1126/science.1205106.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95060, USA. jestes@ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764740" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Ecosystem ; *Extinction, Biological ; Feeding Behavior ; *Food Chain ; Humans ; Introduced Species ; Population Dynamics ; Predatory Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ebert, Dieter -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):539-40. doi: 10.1126/science.1202092.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universitat Basel, Zoological Institute, Vesalgasse 1, 4059 Basel, Switzerland. dieter.ebert@unibas.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292957" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; *Biological Evolution ; Daphnia/*genetics/physiology ; *Ecosystem ; *Environment ; Evolution, Molecular ; *Gene Duplication ; *Genome ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):514-7. doi: 10.1126/science.333.6042.514.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798909" target="_blank"〉PubMed〈/a〉
    Keywords: Afghan Campaign 2001- ; Art Therapy ; Brain/pathology ; Brain Injuries/*diagnosis/epidemiology/pathology/psychology/*therapy ; Comorbidity ; Humans ; Iraq War, 2003-2011 ; *Military Personnel ; Stress Disorders, Post-Traumatic/*diagnosis/epidemiology/psychology/*therapy ; United States ; United States Department of Defense ; User-Computer Interface ; Veterans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1210-1. doi: 10.1126/science.333.6047.1210.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885748" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/growth & development ; China ; *Ecosystem ; Eutrophication ; *Fresh Water/chemistry/microbiology ; *Harmful Algal Bloom ; Microcystis/*growth & development ; Potamogetonaceae/growth & development ; Water Pollutants, Chemical/*toxicity ; Water Pollution/economics/*prevention & control ; Water Supply
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2011-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1209. doi: 10.1126/science.333.6047.1209.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885747" target="_blank"〉PubMed〈/a〉
    Keywords: Actinobacteria/*isolation & purification ; *Archaea/isolation & purification/physiology ; Bacteroidetes/*isolation & purification ; China ; *Ecosystem ; Food Chain ; Hot Springs/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2011-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zarin, Debora -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):145. doi: 10.1126/science.333.6039.145.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21737714" target="_blank"〉PubMed〈/a〉
    Keywords: *Clinical Trials as Topic ; *Databases, Factual ; Internet ; National Library of Medicine (U.S.) ; *Registries ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):817. doi: 10.1126/science.333.6044.817.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21835994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China/epidemiology ; *Ecosystem ; *Energy-Generating Resources ; *Environment ; Humans ; *Rivers ; Schistosomiasis/epidemiology/transmission ; Snails ; Water Movements
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2011-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iacopino, Vincent -- Allen, Scott A -- Keller, Allen S -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):34-5. doi: 10.1126/science.1194437.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physicians for Human Rights, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212341" target="_blank"〉PubMed〈/a〉
    Keywords: Ethics, Medical ; *Ethics, Professional ; Ethics, Research ; Federal Government ; *Human Experimentation/ethics/legislation & jurisprudence ; Humans ; *Prisoners ; *Torture/ethics/legislation & jurisprudence/psychology ; United States ; United States Department of Defense
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 11
    Publication Date: 2011-11-15
    Description: With its high-energy phosphate bonds, adenosine triphosphate (ATP) is the main intracellular energy carrier. It also functions in most signaling pathways, as a phosphate donor or a precursor for cyclic adenosine monophosphate. We show here that inositol pyrophosphates participate in the control of intracellular ATP concentration. Yeasts devoid of inositol pyrophosphates have dysfunctional mitochondria but, paradoxically, contain four times as much ATP because of increased glycolysis. We demonstrate that inositol pyrophosphates control the activity of the major glycolytic transcription factor GCR1. Thus, inositol pyrophosphates regulate ATP concentration by altering the glycolytic/mitochondrial metabolic ratio. Metabolic reprogramming through inositol pyrophosphates is an evolutionary conserved mechanism that is also preserved in mammalian systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szijgyarto, Zsolt -- Garedew, Assegid -- Azevedo, Cristina -- Saiardi, Adolfo -- G1001704/Medical Research Council/United Kingdom -- MC_U122680443/Medical Research Council/United Kingdom -- PG/10/72/28449/British Heart Foundation/United Kingdom -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):802-5. doi: 10.1126/science.1211908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076377" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Adenosine Monophosphate/metabolism ; Adenosine Triphosphate/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; *Energy Metabolism ; Gene Expression Regulation, Fungal ; Glucose/metabolism ; Glycolysis/genetics ; Inositol Phosphates/*metabolism ; Mitochondria/metabolism ; Mutation ; NAD/metabolism ; Oxidation-Reduction ; Oxidative Phosphorylation ; Oxygen Consumption ; Phosphorylation ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/genetics/growth & development/*metabolism ; Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism ; Transcription Factors/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 12
    Publication Date: 2011-11-05
    Description: Climate change challenges organisms to adapt or move to track changes in environments in space and time. We used two measures of thermal shifts from analyses of global temperatures over the past 50 years to describe the pace of climate change that species should track: the velocity of climate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures. Both measures are higher in the ocean than on land at some latitudes, despite slower ocean warming. These indices give a complex mosaic of predicted range shifts and phenology changes that deviate from simple poleward migration and earlier springs or later falls. They also emphasize potential conservation concerns, because areas of high marine biodiversity often have greater velocities of climate change and seasonal shifts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burrows, Michael T -- Schoeman, David S -- Buckley, Lauren B -- Moore, Pippa -- Poloczanska, Elvira S -- Brander, Keith M -- Brown, Chris -- Bruno, John F -- Duarte, Carlos M -- Halpern, Benjamin S -- Holding, Johnna -- Kappel, Carrie V -- Kiessling, Wolfgang -- O'Connor, Mary I -- Pandolfi, John M -- Parmesan, Camille -- Schwing, Franklin B -- Sydeman, William J -- Richardson, Anthony J -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):652-5. doi: 10.1126/science.1210288.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Scottish Association for Marine Science, Scottish Marine Institute, Oban, Argyll, PA37 1QA, Scotland, UK. michael.burrows@sams.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053045" target="_blank"〉PubMed〈/a〉
    Keywords: Biodiversity ; *Climate Change ; *Ecosystem ; Oceans and Seas ; Seasons
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 13
    Publication Date: 2011-03-26
    Description: Pervasive transcription of eukaryotic genomes generates a plethora of noncoding RNAs. In fission yeast, the heterochromatin factor Clr4/Suv39 methyltransferase facilitates RNA interference (RNAi)-mediated processing of centromeric transcripts into small interfering RNAs (siRNAs). Clr4 also mediates degradation of antisense RNAs at euchromatic loci, but the underlying mechanism has remained elusive. We show that Clr4 and the RNAi effector RITS (RNA-induced transcriptional silencing) interact with Mlo3, a protein related to mRNA quality control and export factors. Loss of Clr4 impairs RITS interaction with Mlo3, which is required for centromeric siRNA production and antisense suppression. Mlo3 also interacts with the RNA surveillance factor TRAMP, which suppresses antisense RNAs targeted by Clr4 and RNAi. These findings link Clr4 to RNA quality control machinery and suggest a pathway for processing potentially deleterious RNAs through the coordinated actions of RNAi and other RNA processing activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Ke -- Fischer, Tamas -- Porter, Rebecca L -- Dhakshnamoorthy, Jothy -- Zofall, Martin -- Zhou, Ming -- Veenstra, Timothy -- Grewal, Shiv I S -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1624-7. doi: 10.1126/science.1198712.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry and Molecular Biology, National Cancer Institute/NIH, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436456" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle Proteins/genetics/*metabolism ; Centromere/metabolism ; Euchromatin/metabolism ; Histones/metabolism ; Methylation ; Methyltransferases/genetics/*metabolism ; Mutation ; *RNA Interference ; RNA Processing, Post-Transcriptional ; RNA, Antisense/*metabolism ; RNA, Fungal/*metabolism ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Schizosaccharomyces/*genetics/*metabolism ; Schizosaccharomyces pombe Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 14
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agre, Peter -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):416-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21284129" target="_blank"〉PubMed〈/a〉
    Keywords: Aquaporin 1/history ; Chemistry/history ; History, 20th Century ; History, 21st Century ; International Cooperation ; Nobel Prize ; *Science/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 15
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leshner, Alan I -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):738. doi: 10.1126/science.1215299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076346" target="_blank"〉PubMed〈/a〉
    Keywords: *Financing, Government ; *Policy ; *Research Support as Topic ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 16
    Publication Date: 2011-11-15
    Description: The most common catalyst in the Haber-Bosch process for the hydrogenation of dinitrogen (N(2)) to ammonia (NH(3)) is an iron surface promoted with potassium cations (K(+)), but soluble iron complexes have neither reduced the N-N bond of N(2) to nitride (N(3-)) nor produced large amounts of NH(3) from N(2). We report a molecular iron complex that reacts with N(2) and a potassium reductant to give a complex with two nitrides, which are bound to iron and potassium cations. The product has a Fe(3)N(2) core, implying that three iron atoms cooperate to break the N-N triple bond through a six-electron reduction. The nitride complex reacts with acid and with H(2) to give substantial yields of N(2)-derived ammonia. These reactions, although not yet catalytic, give structural and spectroscopic insight into N(2) cleavage and N-H bond-forming reactions of iron.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218428/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218428/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodriguez, Meghan M -- Bill, Eckhard -- Brennessel, William W -- Holland, Patrick L -- GM-065313/GM/NIGMS NIH HHS/ -- R01 GM065313/GM/NIGMS NIH HHS/ -- R01 GM065313-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):780-3. doi: 10.1126/science.1211906.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076372" target="_blank"〉PubMed〈/a〉
    Keywords: Acids/chemistry ; Ammonia/*chemistry ; Catalysis ; Crystallography, X-Ray ; Ferric Compounds/*chemistry ; Ferrous Compounds/*chemistry ; Graphite/chemistry ; Hydrogenation ; Molecular Structure ; Nitrogen/*chemistry ; Oxidation-Reduction ; Physicochemical Processes ; Potassium/chemistry ; Potassium Compounds/*chemistry ; Spectroscopy, Mossbauer
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 17
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):23-4. doi: 10.1126/science.333.6038.23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719652" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic ; *Health Promotion ; Humans ; Peer Group ; *Product Labeling ; Psychology, Social ; *Smoking/adverse effects/prevention & control/psychology ; *Smoking Cessation/psychology ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 18
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minke, Baruch -- Peters, Maximilian -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1272-3. doi: 10.1126/science.1203482.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Neurobiology, The Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University, Jerusalem, Israel. baruchm@ekmd.huji.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila Proteins/genetics/metabolism/*physiology ; Drosophila melanogaster/genetics/*physiology ; Larva/physiology ; Light ; Mutation ; Photoreceptor Cells, Invertebrate/physiology ; Rhodopsin/chemistry/genetics/*physiology ; TRPC Cation Channels/metabolism ; Temperature ; *Thermosensing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 19
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elsasser, Simon J -- Allis, C David -- Lewis, Peter W -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1145-6. doi: 10.1126/science.1203280.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21385704" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/*genetics/metabolism ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/genetics ; DNA Helicases/*genetics/metabolism ; *Epigenesis, Genetic ; *Genes, Tumor Suppressor ; Histones/metabolism ; Humans ; Mutation ; Neuroendocrine Tumors/*genetics/metabolism ; Nuclear Proteins/*genetics/metabolism ; Nucleosomes/metabolism ; Pancreatic Neoplasms/*genetics/metabolism ; Proto-Oncogene Proteins/*genetics/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 20
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charles, Dan -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):28-9. doi: 10.1126/science.333.6038.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719655" target="_blank"〉PubMed〈/a〉
    Keywords: *Research ; Salmonella/pathogenicity/physiology ; *Space Flight ; *Spacecraft ; United States ; *United States National Aeronautics and Space Administration ; Weightlessness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 21
    Publication Date: 2011-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):292. doi: 10.1126/science.332.6027.292.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms/*metabolism/*radiation effects ; *Ecosystem ; Food Chain ; Japan ; Pacific Ocean ; Phytoplankton/metabolism/radiation effects ; Radiation Dosage ; *Radioisotopes/pharmacokinetics/toxicity ; Seaweed/metabolism/radiation effects ; *Water Pollutants, Radioactive/pharmacokinetics/toxicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 22
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1252. doi: 10.1126/science.331.6022.1252.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393519" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Pollution/*adverse effects ; Follow-Up Studies ; *Health Status ; *Health Surveys ; Humans ; *Mental Health ; National Institute of Environmental Health Sciences (U.S.) ; Occupational Exposure/*adverse effects ; Petroleum/*toxicity ; Population Surveillance ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 23
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosbash, Michael -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):136. doi: 10.1126/science.1210374.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21737707" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics/organization & administration ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 24
    Publication Date: 2011-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1192-3. doi: 10.1126/science.334.6060.1192.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioterrorism ; Ferrets ; *Host Specificity ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza in Birds/virology ; Influenza, Human/epidemiology/mortality/transmission/*virology ; International Cooperation ; Netherlands ; Orthomyxoviridae Infections/epidemiology/transmission/veterinary/*virology ; *Pandemics ; Poultry ; Publishing ; Serial Passage ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 25
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hrabowski, Freeman A 3rd -- New York, N.Y. -- Science. 2011 Jan 14;331(6014):125. doi: 10.1126/science.1202388.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233350" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate ; Engineering/education/manpower ; Humans ; Mathematics/*education/manpower ; Mentors ; Minority Groups/*education ; Science/*education/manpower ; Social Support ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 26
    Publication Date: 2011-03-12
    Description: Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle elongation are linked. Here, we find that yeast cells could cope with a 45% increase in the length of their longest chromosome arm by increasing its condensation. The spindle midzone, aurora/Ipl1 activity, and Ser10 of histone H3 mediated this response. Thus, the anaphase spindle may function as a ruler to adapt the condensation of chromatids, promoting their segregation regardless of chromosome or spindle length.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neurohr, Gabriel -- Naegeli, Andreas -- Titos, Iris -- Theler, Dominik -- Greber, Basil -- Diez, Javier -- Gabaldon, Toni -- Mendoza, Manuel -- Barral, Yves -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):465-8. doi: 10.1126/science.1201578. Epub 2011 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Genomic Regulation (CRG), Barcelona, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393511" target="_blank"〉PubMed〈/a〉
    Keywords: Aldose-Ketose Isomerases/genetics ; *Anaphase ; Aurora Kinases ; Chromosome Segregation ; Chromosomes, Fungal/genetics/*physiology ; Histones/metabolism ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; Microtubule-Associated Proteins/genetics/metabolism ; Mutation ; Protein-Serine-Threonine Kinases/genetics/metabolism ; Saccharomyces cerevisiae/genetics/*physiology ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; Spindle Apparatus/*physiology/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 27
    Publication Date: 2011-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischer, Joern -- Batary, Peter -- Bawa, Kamaljit S -- Brussaard, Lijbert -- Chappell, M Jahi -- Clough, Yann -- Daily, Gretchen C -- Dorrough, Josh -- Hartel, Tibor -- Jackson, Louise E -- Klein, Alexandra M -- Kremen, Claire -- Kuemmerle, Tobias -- Lindenmayer, David B -- Mooney, Harold A -- Perfecto, Ivette -- Philpott, Stacy M -- Tscharntke, Teja -- Vandermeer, John -- Wanger, Thomas Cherico -- Von Wehrden, Henrik -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):593; author reply 594-5. doi: 10.1126/science.334.6056.593-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053026" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Animals ; *Biodiversity ; *Conservation of Natural Resources ; Crops, Agricultural/*growth & development ; *Ecosystem ; *Food
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 28
    Publication Date: 2011-08-13
    Description: Estimates suggest that only one-tenth of the true fungal diversity has been described. Among numerous fungal lineages known only from environmental DNA sequences, Soil Clone Group 1 is the most ubiquitous. These globally distributed fungi may dominate below-ground fungal communities, but their placement in the fungal tree of life has been uncertain. Here, we report cultures of this group and describe the class, Archaeorhizomycetes, phylogenetically placed within subphylum Taphrinomycotina in the Ascomycota. Archaeorhizomycetes comprises hundreds of cryptically reproducing filamentous species that do not form recognizable mycorrhizal structures and have saprotrophic potential, yet are omnipresent in roots and rhizosphere soil and show ecosystem and host root habitat specificity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosling, Anna -- Cox, Filipa -- Cruz-Martinez, Karelyn -- Ihrmark, Katarina -- Grelet, Gwen-Aelle -- Lindahl, Bjorn D -- Menkis, Audrius -- James, Timothy Y -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):876-9. doi: 10.1126/science.1206958.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Forest Mycology and Pathology, Uppsala BioCentre, SLU, Box 7026, 750 07 Uppsala, Sweden. anna.rosling@slu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836015" target="_blank"〉PubMed〈/a〉
    Keywords: *Ascomycota/classification/genetics/growth & development/isolation & purification ; Coniferophyta/microbiology ; *Ecosystem ; Genes, Fungal ; Genes, rRNA ; Meristem/*microbiology ; Molecular Sequence Data ; *Mycorrhizae/classification/genetics ; Phylogeny ; Rhizosphere ; *Soil Microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 29
    Publication Date: 2011-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, Brendan -- Naidoo, Robin -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):287; author reply 287-8. doi: 10.1126/science.333.6040.287-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764731" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*economics ; Animals ; *Chiroptera ; Crops, Agricultural/*economics ; *Ecosystem ; Pest Control, Biological/*economics ; Population Dynamics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 30
    Publication Date: 2011-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reganold, J P -- Jackson-Smith, D -- Batie, S S -- Harwood, R R -- Kornegay, J L -- Bucks, D -- Flora, C B -- Hanson, J C -- Jury, W A -- Meyer, D -- Schumacher, A Jr -- Sehmsdorf, H -- Shennan, C -- Thrupp, L A -- Willis, P -- New York, N.Y. -- Science. 2011 May 6;332(6030):670-1. doi: 10.1126/science.1202462.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Washington State University, Pullman, WA 99164, USA. reganold@wsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21551050" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture/economics/legislation & jurisprudence/methods ; Conservation of Natural Resources ; Environment ; Policy ; Politics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 31
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1549. doi: 10.1126/science.331.6024.1549.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436440" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Breast Neoplasms/diagnosis/prevention & control/therapy ; Canada ; *Delivery of Health Care ; Developing Countries ; Female ; *Health Knowledge, Attitudes, Practice ; Health Services Accessibility ; History, 20th Century ; History, 21st Century ; Humans ; Mexico ; *Neoplasms/diagnosis/therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 32
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huff, James -- New York, N.Y. -- Science. 2011 May 20;332(6032):916-7. doi: 10.1126/science.332.6032.916-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596974" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogenicity Tests ; *Carcinogens/classification/toxicity ; Environmental Exposure ; Humans ; Neoplasms/*prevention & control ; Occupational Exposure ; Primary Prevention ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 33
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, Christopher -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):936. doi: 10.1126/science.333.6045.936-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852471" target="_blank"〉PubMed〈/a〉
    Keywords: Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; *Introduced Species
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 34
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2011 Mar 25;331(6024):1540-4. doi: 10.1126/science.331.6024.1540-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436435" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/history/therapeutic use ; Biomedical Research/*history ; History, 20th Century ; History, 21st Century ; Humans ; National Cancer Institute (U.S.)/*history/legislation & jurisprudence ; Neoplasms/epidemiology/*history/therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 35
    Publication Date: 2011-04-30
    Description: Catastrophic ecological regime shifts may be announced in advance by statistical early warning signals such as slowing return rates from perturbation and rising variance. The theoretical background for these indicators is rich, but real-world tests are rare, especially for whole ecosystems. We tested the hypothesis that these statistics would be early warning signals for an experimentally induced regime shift in an aquatic food web. We gradually added top predators to a lake over 3 years to destabilize its food web. An adjacent lake was monitored simultaneously as a reference ecosystem. Warning signals of a regime shift were evident in the manipulated lake during reorganization of the food web more than a year before the food web transition was complete, corroborating theory for leading indicators of ecological regime shifts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carpenter, S R -- Cole, J J -- Pace, M L -- Batt, R -- Brock, W A -- Cline, T -- Coloso, J -- Hodgson, J R -- Kitchell, J F -- Seekell, D A -- Smith, L -- Weidel, B -- New York, N.Y. -- Science. 2011 May 27;332(6033):1079-82. doi: 10.1126/science.1203672. Epub 2011 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Limnology, University of Wisconsin, Madison, WI 53706, USA. srcarpen@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527677" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bass ; Biomass ; Chlorophyll/analysis ; *Ecosystem ; *Fishes ; *Food Chain ; *Fresh Water/chemistry ; Models, Biological ; Nonlinear Dynamics ; *Phytoplankton ; Population Dynamics ; *Zooplankton
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 36
    Publication Date: 2011-05-14
    Description: We describe a general computational method for designing proteins that bind a surface patch of interest on a target macromolecule. Favorable interactions between disembodied amino acid residues and the target surface are identified and used to anchor de novo designed interfaces. The method was used to design proteins that bind a conserved surface patch on the stem of the influenza hemagglutinin (HA) from the 1918 H1N1 pandemic virus. After affinity maturation, two of the designed proteins, HB36 and HB80, bind H1 and H5 HAs with low nanomolar affinity. Further, HB80 inhibits the HA fusogenic conformational changes induced at low pH. The crystal structure of HB36 in complex with 1918/H1 HA revealed that the actual binding interface is nearly identical to that in the computational design model. Such designed binding proteins may be useful for both diagnostics and therapeutics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164876/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164876/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleishman, Sarel J -- Whitehead, Timothy A -- Ekiert, Damian C -- Dreyfus, Cyrille -- Corn, Jacob E -- Strauch, Eva-Maria -- Wilson, Ian A -- Baker, David -- AI057141/AI/NIAID NIH HHS/ -- AI058113/AI/NIAID NIH HHS/ -- GM080209/GM/NIGMS NIH HHS/ -- P01 AI058113/AI/NIAID NIH HHS/ -- P01 AI058113-07/AI/NIAID NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 May 13;332(6031):816-21. doi: 10.1126/science.1202617.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566186" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Sequence ; Binding Sites ; Computational Biology ; *Computer Simulation ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; *Models, Molecular ; Molecular Sequence Data ; Mutation ; Peptide Library ; Protein Binding ; Protein Conformation ; *Protein Engineering ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Proteins/*chemistry/genetics/*metabolism ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 37
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nichols, Rodney W -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1381. doi: 10.1126/science.333.6048.1381-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903795" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; *International Cooperation ; United States ; *United States Agency for International Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 38
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, Sean B -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1100-1. doi: 10.1126/science.1211025.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin-Madison, 201 Bock Laboratories, Madison, WI 53706, USA. sbcarrol@facstaff.wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868661" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Animals ; *Biological Evolution ; Butterflies/anatomy & histology/*genetics ; *Genes, Insect ; Genetic Variation ; Mutation ; Phenotype ; Pigmentation/*genetics ; Regulatory Sequences, Nucleic Acid ; Selection, Genetic ; Wings, Animal/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 39
    Publication Date: 2011-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hulme, Mike -- Mahony, Martin -- Beck, Silke -- Gorg, Christoph -- Hansjurgens, Bernd -- Hauck, Jennifer -- Nesshover, Carsten -- Paulsch, Axel -- Vandewalle, Marie -- Wittmer, Heidi -- Boschen, Stefan -- Bridgewater, Peter -- Diaw, Mariteuw Chimere -- Fabre, Pierre -- Figueroa, Aurelia -- Heong, Kong Luen -- Korn, Horst -- Leemans, Rik -- Lovbrand, Eva -- Hamid, Mohd Norowi -- Monfreda, Chad -- Pielke, Roger Jr -- Settele, Josef -- Winter, Marten -- Vadrot, Alice B M -- van den Hove, Sybille -- van der Sluijs, Jeroen P -- New York, N.Y. -- Science. 2011 Aug 5;333(6043):697-8. doi: 10.1126/science.333.6043.697.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817033" target="_blank"〉PubMed〈/a〉
    Keywords: *Biodiversity ; *Ecosystem ; *Policy ; Policy Making
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 40
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-19
    Description: Dyneins are microtubule-based motor proteins that power ciliary beating, transport intracellular cargos, and help to construct the mitotic spindle. Evolved from ring-shaped hexameric AAA-family adenosine triphosphatases (ATPases), dynein's large size and complexity have posed challenges for understanding its structure and mechanism. Here, we present a 6 angstrom crystal structure of a functional dimer of two ~300-kilodalton motor domains of yeast cytoplasmic dynein. The structure reveals an unusual asymmetric arrangement of ATPase domains in the ring-shaped motor domain, the manner in which the mechanical element interacts with the ATPase ring, and an unexpected interaction between two coiled coils that create a base for the microtubule binding domain. The arrangement of these elements provides clues as to how adenosine triphosphate-driven conformational changes might be transmitted across the motor domain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169322/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169322/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, Andrew P -- Cho, Carol -- Jin, Lan -- Vale, Ronald D -- MC_UP_A025_1011/Medical Research Council/United Kingdom -- R01 GM097312/GM/NIGMS NIH HHS/ -- R01 GM097312-01/GM/NIGMS NIH HHS/ -- R01 GM097312-02/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1159-65. doi: 10.1126/science.1202393. Epub 2011 Feb 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California-San Francisco, 600 16th Street, San Francisco, CA 94158, USA. cartera@mrc-lmb.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330489" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Cytoplasmic Dyneins/*chemistry/*metabolism ; Methionine/chemistry ; Microtubules/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Folding ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry ; Saccharomyces cerevisiae Proteins/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 41
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flueck, Werner T -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1092-3. doi: 10.1126/science.333.6046.1092-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868651" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; Entropy ; *Food Chain ; Photosynthesis ; Predatory Behavior ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 42
    Publication Date: 2011-03-10
    Description: Light-responsive neural activity in central brain neurons is generally conveyed through opsin-based signaling from external photoreceptors. Large lateral ventral arousal neurons (lLNvs) in Drosophila melanogaster increase action potential firing within seconds in response to light in the absence of all opsin-based photoreceptors. Light-evoked changes in membrane resting potential occur in about 100 milliseconds. The light response is selective for blue wavelengths corresponding to the spectral sensitivity of CRYPTOCHROME (CRY). cry-null lines are light-unresponsive, but restored CRY expression in the lLNv rescues responsiveness. Furthermore, expression of CRY in neurons that are normally unresponsive to light confers responsiveness. The CRY-mediated light response requires a flavin redox-based mechanism and depends on potassium channel conductance, but is independent of the classical circadian CRY-TIMELESS interaction.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418525/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418525/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fogle, Keri J -- Parson, Kelly G -- Dahm, Nicole A -- Holmes, Todd C -- NS046750/NS/NINDS NIH HHS/ -- R01 GM102965/GM/NIGMS NIH HHS/ -- R01 NS046750/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 18;331(6023):1409-13. doi: 10.1126/science.1199702. Epub 2011 Mar 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, University of California-Irvine, Irvine, CA 92697, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21385718" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Circadian Clocks ; Circadian Rhythm ; Compound Eye, Arthropod/physiology ; Cryptochromes/genetics/*metabolism ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/genetics/*physiology ; Eye Proteins/genetics/*metabolism ; Flavins/metabolism ; Genes, Insect ; *Light ; Mutation ; Neurons/physiology ; Oxidation-Reduction ; Patch-Clamp Techniques ; Photoreceptor Cells, Invertebrate/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 43
    Publication Date: 2011-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jepson, Paul -- Jennings, Steve -- Jones, Kate E -- Hodgetts, Timothy -- New York, N.Y. -- Science. 2011 Dec 9;334(6061):1351-2. doi: 10.1126/science.1213189.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Geography and the Environment, University of Oxford, Oxford, OX1 3QY, UK. paul.jepson@ouce.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22158806" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/*economics ; *Ecosystem ; *Environment ; International Cooperation ; Motion Pictures as Topic/*economics ; Organizations, Nonprofit ; Policy ; Television/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 44
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caruthers, Marvin -- Wells, Robert -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1511. doi: 10.1126/science.1217138.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. marvin.caruthers@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22174242" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/*history ; Chemistry/*history ; History, 20th Century ; History, 21st Century ; Nobel Prize ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 45
    Publication Date: 2011-09-03
    Description: In our view, synthetic biology is an extension of the continuum of genetic science that has been used safely for more than 40 years by the biotechnology industry in the development of commercial products. Examples of synthetic biology use by biotechnology companies illustrate the potential to substantially reduce research and development time and to increase speed to market. Improvements in the speed and cost of DNA synthesis are enabling scientists to design modified bacterial chromosomes that can be used in the production of renewable chemicals, biofuels, bioproducts, renewable specialty chemicals, pharmaceutical intermediates, fine chemicals, food ingredients, and health care products. Regulatory options should support innovation and commercial development of new products while protecting the public from potential harms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, Brent -- Singh, Rina -- Winters, Paul -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1254-6. doi: 10.1126/science.1211066.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biotechnology Industry Organization (BIO), Washington, DC 20024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885775" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; *Biotechnology/ethics/legislation & jurisprudence/methods/standards ; Diffusion of Innovation ; Genetic Engineering ; *Government Regulation ; Guidelines as Topic ; Public Policy ; *Synthetic Biology/ethics/legislation & jurisprudence/methods/standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 46
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lieberman Aiden, Erez -- 1DP2OD008540-01/OD/NIH HHS/ -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1222-3. doi: 10.1126/science.1216288.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard Society of Fellows, Harvard University, Cambridge, MA 02138, USA. erez@erez.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144611" target="_blank"〉PubMed〈/a〉
    Keywords: Awards and Prizes ; Cell Nucleus/*ultrastructure ; Chromatin/*chemistry ; *Chromosome Mapping ; Chromosomes, Human/chemistry/ultrastructure ; DNA/*chemistry ; *Genetic Loci ; *Genome, Human ; History, 21st Century ; Humans ; Nucleic Acid Conformation ; Protein Folding ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 47
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1369. doi: 10.1126/science.333.6048.1369.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903787" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds ; Disease Outbreaks/statistics & numerical data/veterinary ; Humans ; *Influenza A Virus, H5N1 Subtype/genetics/immunology ; Influenza Vaccines ; Influenza in Birds/*epidemiology/prevention & control/virology ; Influenza, Human/*epidemiology ; Mutation ; Poultry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 48
    Publication Date: 2011-08-27
    Description: Zhao and Running (Reports, 20 August 2010, p. 940) reported a reduction in global terrestrial net primary production (NPP) from 2000 through 2009. We argue that the small trends, regional patterns, and interannual variations that they describe are artifacts of their NPP model. Satellite observations of vegetation activity show no statistically significant changes in more than 85% of the vegetated lands south of 70 degrees N during the same 2000 to 2009 period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samanta, Arindam -- Costa, Marcos H -- Nunes, Edson L -- Vieira, Simone A -- Xu, Liang -- Myneni, Ranga B -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1093; author reply 1093. doi: 10.1126/science.1199048.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography and Environment, Boston University, Boston, MA 02215, USA. arindam.sam@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868655" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Biomass ; *Carbon Cycle ; Carbon Dioxide ; *Droughts ; *Ecosystem ; Photosynthesis ; Plants/*metabolism ; South America
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 49
    Publication Date: 2011-06-28
    Description: Centrosomes organize the bipolar mitotic spindle, and centrosomal defects cause chromosome instability. Protein phosphorylation modulates centrosome function, and we provide a comprehensive map of phosphorylation on intact yeast centrosomes (18 proteins). Mass spectrometry was used to identify 297 phosphorylation sites on centrosomes from different cell cycle stages. We observed different modes of phosphoregulation via specific protein kinases, phosphorylation site clustering, and conserved phosphorylated residues. Mutating all eight cyclin-dependent kinase (Cdk)-directed sites within the core component, Spc42, resulted in lethality and reduced centrosomal assembly. Alternatively, mutation of one conserved Cdk site within gamma-tubulin (Tub4-S360D) caused mitotic delay and aberrant anaphase spindle elongation. Our work establishes the extent and complexity of this prominent posttranslational modification in centrosome biology and provides specific examples of phosphorylation control in centrosome function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825980/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825980/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keck, Jamie M -- Jones, Michele H -- Wong, Catherine C L -- Binkley, Jonathan -- Chen, Daici -- Jaspersen, Sue L -- Holinger, Eric P -- Xu, Tao -- Niepel, Mario -- Rout, Michael P -- Vogel, Jackie -- Sidow, Arend -- Yates, John R 3rd -- Winey, Mark -- F32 GM086038/GM/NIGMS NIH HHS/ -- GM51312/GM/NIGMS NIH HHS/ -- MOP-64404/Canadian Institutes of Health Research/Canada -- P41 RR011823/RR/NCRR NIH HHS/ -- R01 GM051312/GM/NIGMS NIH HHS/ -- R01 GM051312-16/GM/NIGMS NIH HHS/ -- R01 GM051312-16S1/GM/NIGMS NIH HHS/ -- R01 GM062427/GM/NIGMS NIH HHS/ -- R01 HG003039/HG/NHGRI NIH HHS/ -- T32 GM008759/GM/NIGMS NIH HHS/ -- U54 RR022220/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1557-61. doi: 10.1126/science.1205193.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700874" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; CDC2 Protein Kinase/metabolism ; *Cell Cycle ; Centrosome/*metabolism/ultrastructure ; Cytoskeletal Proteins/genetics/metabolism ; Fungal Proteins/chemistry/metabolism ; Fungi/metabolism ; G1 Phase ; Mitosis ; Mutation ; Phosphoproteins/genetics/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Proteome/*metabolism ; Saccharomyces cerevisiae/cytology/genetics/growth & development/*metabolism ; Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism ; Spindle Apparatus/metabolism/ultrastructure ; Tubulin/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 50
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- Enserink, Martin -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1694-701. doi: 10.1126/science.333.6050.1694.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940874" target="_blank"〉PubMed〈/a〉
    Keywords: Blood/virology ; DNA Contamination ; Endoribonucleases/genetics/metabolism ; Fatigue Syndrome, Chronic/*virology ; Humans ; Male ; Mutation ; Prostatic Neoplasms/virology ; Publishing ; Retroviridae Infections/*virology ; Xenotropic murine leukemia virus-related virus/classification/*isolation & ; purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 51
    Publication Date: 2011-09-24
    Description: The positioning of nucleosomes within the coding regions of eukaryotic genes is aligned with respect to transcriptional start sites. This organization is likely to influence many genetic processes, requiring access to the underlying DNA. Here, we show that the combined action of Isw1 and Chd1 nucleosome-spacing enzymes is required to maintain this organization. In the absence of these enzymes, regular positioning of the majority of nucleosomes is lost. Exceptions include the region upstream of the promoter, the +1 nucleosome, and a subset of locations distributed throughout coding regions where other factors are likely to be involved. These observations indicate that adenosine triphosphate-dependent remodeling enzymes are responsible for directing the positioning of the majority of nucleosomes within the Saccharomyces cerevisiae genome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428865/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428865/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gkikopoulos, Triantaffyllos -- Schofield, Pieta -- Singh, Vijender -- Pinskaya, Marina -- Mellor, Jane -- Smolle, Michaela -- Workman, Jerry L -- Barton, Geoffrey J -- Owen-Hughes, Tom -- 064414/Wellcome Trust/United Kingdom -- 095062/Wellcome Trust/United Kingdom -- G0900740/Medical Research Council/United Kingdom -- R01 GM047867/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1758-60. doi: 10.1126/science.1206097.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940898" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/genetics/*metabolism ; Adenosine Triphosphate/metabolism ; Chromatin Assembly and Disassembly ; DNA, Fungal/genetics ; DNA-Binding Proteins/genetics/*metabolism ; Gene Expression Regulation, Fungal ; Genes, Fungal ; *Genome, Fungal ; Mutation ; Nucleosomes/*genetics/physiology/ultrastructure ; Saccharomyces cerevisiae/*genetics/physiology ; Saccharomyces cerevisiae Proteins/genetics/*metabolism ; Transcription Initiation Site
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 52
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pala, Christopher -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):303. doi: 10.1126/science.334.6054.303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021832" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomass ; *Ecosystem ; *Fisheries ; *Fishes ; *Fresh Water ; Kazakhstan ; Oceans and Seas ; Salinity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 53
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Joel E -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1472. doi: 10.1126/science.1217478.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22174216" target="_blank"〉PubMed〈/a〉
    Keywords: Communication ; *Disaster Planning ; *Earthquakes ; Italy ; *Public Policy ; *Science/education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 54
    Publication Date: 2011-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly, R P -- Foley, M M -- Fisher, W S -- Feely, R A -- Halpern, B S -- Waldbusser, G G -- Caldwell, M R -- New York, N.Y. -- Science. 2011 May 27;332(6033):1036-7. doi: 10.1126/science.1203815.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Ocean Solutions, Stanford University, Stanford, CA 94305, USA. rpk@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617060" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/*legislation & jurisprudence ; Ecosystem ; Hydrogen-Ion Concentration ; Oceans and Seas ; Seawater/*chemistry ; United States ; Water Pollution/legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 55
    Publication Date: 2011-07-23
    Description: Many physiological responses in present-day coral reefs to climate change are interpreted as consistent with the imminent disappearance of modern reefs globally because of annual mass bleaching events, carbonate dissolution, and insufficient time for substantial evolutionary responses. Emerging evidence for variability in the coral calcification response to acidification, geographical variation in bleaching susceptibility and recovery, responses to past climate change, and potential rates of adaptation to rapid warming supports an alternative scenario in which reef degradation occurs with greater temporal and spatial heterogeneity than current projections suggest. Reducing uncertainty in projecting coral reef futures requires improved understanding of past responses to rapid climate change; physiological responses to interacting factors, such as temperature, acidification, and nutrients; and the costs and constraints imposed by acclimation and adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pandolfi, John M -- Connolly, Sean R -- Marshall, Dustin J -- Cohen, Anne L -- New York, N.Y. -- Science. 2011 Jul 22;333(6041):418-22. doi: 10.1126/science.1204794.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Research Council (ARC) Centre of Excellence for Coral Reef Studies, St. Lucia, Queensland 4072, Australia. j.pandolfi@uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21778392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa/physiology ; Biodiversity ; Biological Evolution ; Calcification, Physiologic ; Carbon Dioxide/analysis ; Conservation of Natural Resources ; *Ecosystem ; Forecasting ; *Global Warming ; Hydrogen-Ion Concentration ; Oceans and Seas ; Seawater/*chemistry ; Symbiosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 56
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Godfray, H Charles J -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1231-2. doi: 10.1126/science.1211815.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology and Oxford Martin School Institute of Biodiversity, University of Oxford, Oxford OX1 3PS, UK. charles.godfray@zoo.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885765" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Animals ; *Biodiversity ; Birds ; *Conservation of Natural Resources ; Crops, Agricultural/*growth & development ; *Ecosystem ; *Food ; Ghana ; India ; Population Density ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 57
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Godley, Lucy A -- Mondragon, Alfonso -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1017-8. doi: 10.1126/science.1202090.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. lgodley@medicine.bsd.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350155" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalytic Domain ; Crystallography, X-Ray ; Cysteine/chemistry ; DNA/*chemistry/metabolism ; DNA (Cytosine-5-)-Methyltransferase/*chemistry/*metabolism ; *DNA Methylation ; Dinucleoside Phosphates/chemistry/metabolism ; Humans ; Mice ; Models, Molecular ; Protein Structure, Tertiary ; Substrate Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 58
    Publication Date: 2011-07-30
    Description: The initiation of transcription by RNA polymerase II is a multistage process. X-ray crystal structures of transcription complexes containing short RNAs reveal three structural states: one with 2- and 3-nucleotide RNAs, in which only the 3'-end of the RNA is detectable; a second state with 4- and 5-nucleotide RNAs, with an RNA-DNA hybrid in a grossly distorted conformation; and a third state with RNAs of 6 nucleotides and longer, essentially the same as a stable elongating complex. The transition from the first to the second state correlates with a markedly reduced frequency of abortive initiation. The transition from the second to the third state correlates with partial "bubble collapse" and promoter escape. Polymerase structure is permissive for abortive initiation, thereby setting a lower limit on polymerase-promoter complex lifetime and allowing the dissociation of nonspecific complexes. Abortive initiation may be viewed as promoter proofreading, and the structural transitions as checkpoints for promoter control.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179255/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179255/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Xin -- Bushnell, David A -- Silva, Daniel-Adriano -- Huang, Xuhui -- Kornberg, Roger D -- AI21144/AI/NIAID NIH HHS/ -- GM049985/GM/NIGMS NIH HHS/ -- R01 AI021144/AI/NIAID NIH HHS/ -- R01 AI021144-27/AI/NIAID NIH HHS/ -- R01 GM036659/GM/NIGMS NIH HHS/ -- R01 GM049985/GM/NIGMS NIH HHS/ -- R01 GM049985-19/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):633-7. doi: 10.1126/science.1206629.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798951" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallization ; Crystallography, X-Ray ; Models, Molecular ; Molecular Dynamics Simulation ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry/metabolism ; Oligoribonucleotides/chemistry/metabolism ; *Promoter Regions, Genetic ; Protein Conformation ; Protein Structure, Tertiary ; RNA Polymerase II/*chemistry/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/*chemistry/metabolism ; Templates, Genetic ; Transcription Factor TFIIB/chemistry/metabolism ; Transcription Initiation Site ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 59
    Publication Date: 2011-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barcellos-Hoff, Mary Helen -- Brenner, David J -- Brooks, Antone L -- Formenti, Silvia -- Hlatky, Lyn -- Locke, Paul A -- Shore, Roy -- Tenforde, Thomas -- Travis, Elizabeth L -- Williams, Jacqueline -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):305-6. doi: 10.1126/science.332.6027.305-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493843" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Budgets ; Humans ; *Radiation Dosage ; *Radiation Effects ; United States ; United States Government Agencies/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 60
    Publication Date: 2011-02-12
    Description: Memory B cells formed in response to microbial antigens provide immunity to later infections; however, the inability to detect rare endogenous antigen-specific cells limits current understanding of this process. Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM. The more numerous IgM(+) cells were longer lived than the swIg(+) cells. However, swIg(+) memory cells dominated the secondary response because of the capacity to become activated in the presence of neutralizing serum immunoglobulin. Thus, we propose that memory relies on swIg(+) cells until they disappear and serum immunoglobulin falls to a low level, in which case memory resides with durable IgM(+) reserves.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993090/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993090/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pape, Kathryn A -- Taylor, Justin J -- Maul, Robert W -- Gearhart, Patricia J -- Jenkins, Marc K -- F32 AI091033/AI/NIAID NIH HHS/ -- R01 AI036914/AI/NIAID NIH HHS/ -- R01 AI039614/AI/NIAID NIH HHS/ -- R37 AI027998/AI/NIAID NIH HHS/ -- T32 CA009138/CA/NCI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1203-7. doi: 10.1126/science.1201730. Epub 2011 Feb 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310965" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/immunology ; Antigens, CD38/analysis ; B-Lymphocyte Subsets/*immunology ; Cell Survival ; Female ; Germinal Center/cytology/immunology ; Immunization ; *Immunoglobulin Class Switching ; Immunoglobulin M/genetics/*immunology ; *Immunologic Memory ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Phycocyanin/immunology ; Phycoerythrin/immunology ; Spleen/cytology/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 61
    Publication Date: 2011-04-02
    Description: Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPsigma). Here we report that RPTPsigma acts bimodally in sensory neuron extension, mediating CSPG inhibition and HSPG growth promotion. Crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities. Heparan sulfate and analogs induced RPTPsigma ectodomain oligomerization in solution, which was inhibited by chondroitin sulfate. RPTPsigma and HSPGs colocalize in puncta on sensory neurons in culture, whereas CSPGs occupy the extracellular matrix. These results lead to a model where proteoglycans can exert opposing effects on neuronal extension by competing to control the oligomerization of a common receptor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154093/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154093/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coles, Charlotte H -- Shen, Yingjie -- Tenney, Alan P -- Siebold, Christian -- Sutton, Geoffrey C -- Lu, Weixian -- Gallagher, John T -- Jones, E Yvonne -- Flanagan, John G -- Aricescu, A Radu -- 090532/Wellcome Trust/United Kingdom -- 10976/Cancer Research UK/United Kingdom -- EY11559/EY/NEI NIH HHS/ -- G0700232/Medical Research Council/United Kingdom -- G0900084/Medical Research Council/United Kingdom -- HD29417/HD/NICHD NIH HHS/ -- R01 EY011559/EY/NEI NIH HHS/ -- R01 EY011559-19/EY/NEI NIH HHS/ -- R37 HD029417/HD/NICHD NIH HHS/ -- R37 HD029417-20/HD/NICHD NIH HHS/ -- Cancer Research UK/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):484-8. doi: 10.1126/science.1200840. Epub 2011 Mar 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21454754" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Axons/*physiology ; Binding Sites ; Cell Membrane/metabolism ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/chemistry/*metabolism ; Chondroitin Sulfates/chemistry/metabolism ; Crystallography, X-Ray ; Extracellular Matrix ; Ganglia, Spinal ; Glypicans/metabolism ; Growth Cones/metabolism ; Heparan Sulfate Proteoglycans/chemistry/*metabolism ; Heparitin Sulfate/analogs & derivatives/chemistry/metabolism ; Humans ; Mice ; Models, Biological ; Models, Molecular ; Molecular Sequence Data ; Neurites/physiology ; Neurocan/metabolism ; Protein Conformation ; Protein Multimerization ; Protein Structure, Tertiary ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/*chemistry/*metabolism ; Sensory Receptor Cells/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 62
    Publication Date: 2011-02-05
    Description: Reductions in bird numbers could hamper ecosystem services such as pollination, but experimental proof is lacking. We show that functional extinction of bird pollinators has reduced pollination, seed production, and plant density in the shrub Rhabdothamnus solandri (Gesneriaceae) on the North Island ("mainland") of New Zealand but not on three nearby island bird sanctuaries where birds remain abundant. Pollen limitation of fruit set is strong [pollen limitation index (PLI) = 0.69] and significant on the mainland but small (PLI = 0.15) and nonsignificant on islands. Seed production per flower on the mainland is reduced 84%. Mainland sites have similar adult densities, but 55% fewer juvenile plants per adult, than island sites. Seed addition experiments near adult R. solandri plants on the mainland found strong seed limitation 5 years after sowing for R. solandri but not for two other co-occurring woody species. This demonstrates a terrestrial trophic cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Sandra H -- Kelly, Dave -- Ladley, Jenny J -- Molloy, Sue -- Terry, Jon -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1068-71. doi: 10.1126/science.1199092. Epub 2011 Feb 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292938" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/growth & development/*physiology ; Animals ; *Ecosystem ; Extinction, Biological ; Flowers ; Fruit/growth & development ; New Zealand ; *Passeriformes ; *Pollination ; Population Dynamics ; Seed Dispersal ; Seeds ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 63
    Publication Date: 2011-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Adrian -- Kaiser, Jocelyn -- Malakoff, David -- New York, N.Y. -- Science. 2011 Dec 23;334(6063):1613. doi: 10.1126/science.334.6063.1613.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22194535" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; United States ; United States Government Agencies/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 64
    Publication Date: 2011-08-13
    Description: When not transporting cargo, kinesin-1 is autoinhibited by binding of a tail region to the motor domains, but the mechanism of inhibition is unclear. We report the crystal structure of a motor domain dimer in complex with its tail domain at 2.2 angstroms and compare it with a structure of the motor domain alone at 2.7 angstroms. These structures indicate that neither an induced conformational change nor steric blocking is the cause of inhibition. Instead, the tail cross-links the motor domains at a second position, in addition to the coiled coil. This "double lockdown," by cross-linking at two positions, prevents the movement of the motor domains that is needed to undock the neck linker and release adenosine diphosphate. This autoinhibition mechanism could extend to some other kinesins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339660/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339660/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaan, Hung Yi Kristal -- Hackney, David D -- Kozielski, Frank -- NS058848/NS/NINDS NIH HHS/ -- R01 NS058848/NS/NINDS NIH HHS/ -- R01 NS058848-01A2/NS/NINDS NIH HHS/ -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):883-5. doi: 10.1126/science.1204824.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836017" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Amino Acid Sequence ; Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; Drosophila Proteins/*antagonists & inhibitors/*chemistry/metabolism ; Hydrogen Bonding ; Kinesin/*antagonists & inhibitors/*chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Conformation ; Protein Multimerization ; Protein Structure, Tertiary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 65
    Publication Date: 2011-06-28
    Description: Carbon-fluorine bonds are the strongest known single bonds to carbon and as a consequence can prove very hard to cleave. Alhough vinyl and aryl C-F bonds can undergo oxidative addition to transition metal complexes, this reaction has appeared inoperable with aliphatic substrates. We report the addition of C(sp(3))-F bonds (including alkyl-F) to an iridium center via the initial, reversible cleavage of a C-H bond. These results suggest a distinct strategy for the development of catalysts and promoters to make and break C-F bonds, which are of strong interest in the context of both pharmaceutical and environmental chemistry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi, Jongwook -- Wang, David Y -- Kundu, Sabuj -- Choliy, Yuriy -- Emge, Thomas J -- Krogh-Jespersen, Karsten -- Goldman, Alan S -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1545-8. doi: 10.1126/science.1200514.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, New Brunswick, NJ 08903, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700870" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon/*chemistry ; Coordination Complexes/chemistry ; Crystallization ; Crystallography, X-Ray ; Fluorides/chemistry ; Fluorine/*chemistry ; Hydrocarbons, Fluorinated/chemistry ; Hydrogen/*chemistry ; Iridium/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Oxidation-Reduction ; Physicochemical Processes ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 66
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lombardi, Joan -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):957-8. doi: 10.1126/science.333.6045.957.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852485" target="_blank"〉PubMed〈/a〉
    Keywords: Child Care/standards ; Child, Preschool ; *Early Intervention (Education)/standards ; *Education ; Faculty/standards ; Humans ; Politics ; Program Evaluation ; Research ; United States ; United States Dept. of Health and Human Services/*organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 67
    Publication Date: 2011-10-15
    Description: The mitochondrial genome is believed to be maternally inherited in many eukaryotes. Sperm-derived paternal mitochondria enter the oocyte cytoplasm upon fertilization and then normally disappear during early embryogenesis. However, the mechanism responsible for this clearance has been unknown. Here, we show that autophagy, which delivers cytosolic components to lysosomes for degradation, is required for the elimination of paternal mitochondria in Caenorhabditis elegans. Immediately after fertilization, sperm-derived components trigger the localized induction of autophagy around sperm mitochondria. Autophagosomes engulf paternal mitochondria, resulting in their lysosomal degradation during early embryogenesis. In autophagy-defective zygotes, paternal mitochondria and their genome remain even in the first larval stage. Thus, fertilization-triggered autophagy is required for selective degradation of paternal mitochondria and thereby maternal inheritance of mitochondrial DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sato, Miyuki -- Sato, Ken -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1141-4. doi: 10.1126/science.1210333. Epub 2011 Oct 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998252" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autophagy ; Caenorhabditis elegans/*embryology/genetics/physiology ; Caenorhabditis elegans Proteins/genetics/metabolism ; DNA, Helminth/analysis/genetics ; DNA, Mitochondrial/analysis/genetics ; Embryo, Nonmammalian/*physiology ; Embryonic Development ; *Fertilization ; Genome, Mitochondrial ; Hermaphroditic Organisms ; Lysosomes/metabolism ; Male ; Mitochondria/genetics/*metabolism ; Mutation ; Oocytes/physiology ; Phagosomes/*physiology ; Recombinant Fusion Proteins/metabolism ; Spermatozoa/ultrastructure ; Ubiquitination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 68
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Funder, John W -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):685-6. doi: 10.1126/science.1202887.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Prince Henry's Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia. john.funder@princehenrys.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310991" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Neoplasms/*genetics/physiopathology ; Adrenal Glands/pathology ; Adrenocortical Adenoma/*genetics/physiopathology ; Aldosterone/*metabolism ; Animals ; Disease Models, Animal ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/*genetics/metabolism ; Humans ; Hyperaldosteronism/*genetics/physiopathology ; Hyperplasia ; Hypertension/physiopathology ; Male ; Mice ; Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 69
    Publication Date: 2011-11-19
    Description: Gene silencing is essential for regulating cell fate in eukaryotes. Altered chromatin architectures contribute to maintaining the silenced state in a variety of species. The silent information regulator (Sir) proteins regulate mating type in Saccharomyces cerevisiae. One of these proteins, Sir3, interacts directly with the nucleosome to help generate silenced domains. We determined the crystal structure of a complex of the yeast Sir3 BAH (bromo-associated homology) domain and the nucleosome core particle at 3.0 angstrom resolution. We see multiple molecular interactions between the protein surfaces of the nucleosome and the BAH domain that explain numerous genetic mutations. These interactions are accompanied by structural rearrangements in both the nucleosome and the BAH domain. The structure explains how covalent modifications on H4K16 and H3K79 regulate formation of a silencing complex that contains the nucleosome as a central component.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098850/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098850/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armache, Karim-Jean -- Garlick, Joseph D -- Canzio, Daniele -- Narlikar, Geeta J -- Kingston, Robert E -- GM043901/GM/NIGMS NIH HHS/ -- P41 RR012408/RR/NCRR NIH HHS/ -- R01 GM043901/GM/NIGMS NIH HHS/ -- R37 GM048405/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Nov 18;334(6058):977-82. doi: 10.1126/science.1210915.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22096199" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; *Gene Silencing ; Histones/*chemistry/metabolism ; Hydrogen Bonding ; Methylation ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis ; Mutant Proteins/chemistry/metabolism ; Nucleosomes/*chemistry/metabolism/ultrastructure ; Physicochemical Processes ; Protein Folding ; *Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Structure, Tertiary ; Saccharomyces cerevisiae/chemistry/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/chemistry/metabolism ; Silent Information Regulator Proteins, Saccharomyces ; cerevisiae/*chemistry/genetics/metabolism ; Static Electricity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 70
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):753-4. doi: 10.1126/science.334.6057.753.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076357" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Budgets ; *Financing, Government ; National Institutes of Health (U.S.)/*economics/organization & administration ; Research Personnel/supply & distribution ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 71
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):299. doi: 10.1126/science.334.6054.299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021828" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Drug Discovery ; *Drug Evaluation, Preclinical ; High-Throughput Screening Assays ; *National Institutes of Health (U.S.)/economics/organization & administration ; *Small Molecule Libraries ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 72
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cintas, Pedro -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):673. doi: 10.1126/science.331.6018.673-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310983" target="_blank"〉PubMed〈/a〉
    Keywords: Education/*standards ; Educational Measurement ; European Union ; Humans ; Learning ; Mathematics/*education ; Science/*education ; Spain ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 73
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gade, Alexandra M -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):673. doi: 10.1126/science.331.6018.673-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310984" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Financing, Government ; *Research Support as Topic ; United States ; United States Government Agencies/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 74
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1214-5. doi: 10.1126/science.333.6047.1214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885751" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare/*prevention & control ; Bioterrorism/*prevention & control ; Containment of Biohazards/economics ; National Institute of Allergy and Infectious Diseases (U.S.) ; *Security Measures/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 75
    Publication Date: 2011-02-26
    Description: Despite being implicated as important intermediates, iron(V) compounds have proven very challenging to isolate and characterize. Here, we report the preparation of the iron(V) nitrido complex, [PhB((t)BuIm)(3)Fe(V) identical withN]BAr(F24) (PhB((t)BuIm)(3)(-) = phenyltris(3-tert-butylimidazol-2-ylidene)borato, BAr(F24) = B(3,5-(CF(3))(2)C(6)H(3))(4)(-)), by one electron oxidation of the iron(IV) nitrido precursor. Single-crystal x-ray diffraction of the iron(V) complex reveals a four-coordinate metal ion with a terminal nitrido ligand. Mossbauer and electron paramagnetic resonance spectroscopic characterization, supported by electronic structure calculations, provide evidence for a d(3) iron(V) metal center in a low spin (S = 1/2) electron configuration. Low-temperature reaction of the iron(V) nitrido complex with water under reducing conditions leads to high yields of ammonia with concomitant formation of an iron(II) species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scepaniak, Jeremiah J -- Vogel, Carola S -- Khusniyarov, Marat M -- Heinemann, Frank W -- Meyer, Karsten -- Smith, Jeremy M -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1049-52. doi: 10.1126/science.1198315.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, MSC 3C, New Mexico State University, Las Cruces, NM 88003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350172" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallization ; Crystallography, X-Ray ; Electron Spin Resonance Spectroscopy ; Ferric Compounds/chemical synthesis/*chemistry ; Iron/*chemistry ; Ligands ; Molecular Structure ; Nitrogen/chemistry ; Oxidation-Reduction ; Physicochemical Processes ; Spectroscopy, Mossbauer
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 76
    Publication Date: 2011-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1211. doi: 10.1126/science.333.6047.1211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885749" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/therapeutic use ; *Ethics, Research ; Guatemala ; History, 20th Century ; Humans ; *Informed Consent ; Military Personnel ; Nontherapeutic Human Experimentation/ethics/*history ; Penicillins/therapeutic use ; Sexually Transmitted Diseases/*history/prevention & control ; United States ; United States Public Health Service/history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 77
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):925-6. doi: 10.1126/science.333.6045.925.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852462" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans ; *African Continental Ancestry Group ; Biomedical Research/*economics ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; *Peer Review, Research ; Prejudice ; *Research Personnel/economics/education ; Research Support as Topic/*statistics & numerical data ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 78
    Publication Date: 2011-10-01
    Description: Lymphocytes egress from lymphoid organs in response to sphingosine-1-phosphate (S1P); minutes later they migrate from blood into tissue against the S1P gradient. The mechanisms facilitating cell movement against the gradient have not been defined. Here, we show that heterotrimeric guanine nucleotide-binding protein-coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on blood-exposed lymphocytes. T and B cell movement from blood into lymph nodes is reduced in the absence of GRK2 but is restored in S1P-deficient mice. In the spleen, B cell movement between the blood-rich marginal zone and follicles is disrupted by GRK2 deficiency and by mutation of an S1PR1 desensitization motif. Moreover, delivery of systemic antigen into follicles is impaired. Thus, GRK2-dependent S1PR1 desensitization allows lymphocytes to escape circulatory fluids and migrate into lymphoid tissues.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267326/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267326/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnon, Tal I -- Xu, Ying -- Lo, Charles -- Pham, Trung -- An, Jinping -- Coughlin, Shaun -- Dorn, Gerald W -- Cyster, Jason G -- AI74847/AI/NIAID NIH HHS/ -- R01 AI074847/AI/NIAID NIH HHS/ -- R01 AI074847-05/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Sep 30;333(6051):1898-903. doi: 10.1126/science.1208248.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21960637" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Complex/immunology ; B-Lymphocytes/immunology/*physiology ; Blood ; Cell Movement ; Chemokines/physiology ; Chemotaxis, Leukocyte ; Down-Regulation ; G-Protein-Coupled Receptor Kinase 2/*metabolism ; Ligands ; Lymph Nodes/cytology ; Lysophospholipids/metabolism ; Mice ; Mice, Inbred C57BL ; Mutation ; Receptors, Lysosphingolipid/genetics/*metabolism ; Signal Transduction ; Sphingosine/analogs & derivatives/metabolism ; Spleen/cytology/immunology ; T-Lymphocytes/immunology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 79
    Publication Date: 2011-06-04
    Description: Rod-shaped bacteria elongate by the action of cell wall synthesis complexes linked to underlying dynamic MreB filaments. To understand how the movements of these filaments relate to cell wall synthesis, we characterized the dynamics of MreB and the cell wall elongation machinery using high-precision particle tracking in Bacillus subtilis. We found that MreB and the elongation machinery moved circumferentially around the cell, perpendicular to its length, with nearby synthesis complexes and MreB filaments moving independently in both directions. Inhibition of cell wall synthesis by various methods blocked the movement of MreB. Thus, bacteria elongate by the uncoordinated, circumferential movements of synthetic complexes that insert radial hoops of new peptidoglycan during their transit, possibly driving the motion of the underlying MreB filaments.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235694/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235694/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garner, Ethan C -- Bernard, Remi -- Wang, Wenqin -- Zhuang, Xiaowei -- Rudner, David Z -- Mitchison, Tim -- R01 GM039565/GM/NIGMS NIH HHS/ -- R01 GM039565-24/GM/NIGMS NIH HHS/ -- R01 GM073831/GM/NIGMS NIH HHS/ -- R01 GM096450/GM/NIGMS NIH HHS/ -- R01-GM073831/GM/NIGMS NIH HHS/ -- R01-GM096450/GM/NIGMS NIH HHS/ -- R01-GM39565/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):222-5. doi: 10.1126/science.1203285. Epub 2011 Jun 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. ethan.garner@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21636745" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/pharmacology ; Bacillus subtilis/drug effects/*growth & development/*metabolism/ultrastructure ; Bacterial Proteins/chemistry/genetics/*metabolism ; Cell Wall/*metabolism ; Models, Biological ; Morphogenesis ; Motion ; Mutation ; Peptidoglycan/chemistry/*metabolism ; Polymerization ; Recombinant Fusion Proteins/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 80
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Aug 5;333(6043):683. doi: 10.1126/science.333.6043.683.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817023" target="_blank"〉PubMed〈/a〉
    Keywords: *Embryonic Stem Cells ; Humans ; Jurisprudence ; National Institutes of Health (U.S.)/*legislation & jurisprudence ; Stem Cell Research/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 81
    Publication Date: 2011-04-16
    Description: The formate transporter FocA was described to switch its mode of operation from a passive export channel at high external pH to a secondary active formate/H(+) importer at low pH. The crystal structure of Salmonella typhimurium FocA at pH 4.0 shows that this switch involves a major rearrangement of the amino termini of individual protomers in the pentameric channel. The amino-terminal helices open or block transport in a concerted, cooperative action that indicates how FocA is gated in a pH-dependent way. Electrophysiological studies show that the protein acts as a specific formate channel at pH 7.0 and that it closes upon a shift of pH to 5.1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Wei -- Du, Juan -- Wacker, Tobias -- Gerbig-Smentek, Elke -- Andrade, Susana L A -- Einsle, Oliver -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):352-4. doi: 10.1126/science.1199098.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lehrstuhl fur Biochemie, Institut fur organische Chemie und Biochemie, Albert-Ludwigs-Universitat Freiburg, Albertstrasse 21, 79104 Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493860" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/*chemistry/isolation & purification/*metabolism ; Crystallization ; Crystallography, X-Ray ; Formates/*metabolism ; Hydrogen-Ion Concentration ; *Ion Channel Gating ; Ion Channels/*chemistry/isolation & purification/*metabolism ; Ion Transport ; Models, Molecular ; Protein Conformation ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Subunits/chemistry/metabolism ; Salmonella typhimurium/*chemistry/metabolism ; Static Electricity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 82
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arthur, Ronan -- Diamond, Jared -- New York, N.Y. -- Science. 2011 Nov 18;334(6058):911-2. doi: 10.1126/science.1213787.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geography Department, University of California, Los Angeles, CA 90095-1524, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22096177" target="_blank"〉PubMed〈/a〉
    Keywords: *Culture ; Geography ; Humans ; *Indians, North American ; Language ; *Population Growth ; Southwestern United States ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 83
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Asai, David J -- New York, N.Y. -- Science. 2011 May 20;332(6032):895. doi: 10.1126/science.1207680.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596961" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Program Evaluation ; Science/*education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 84
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1492. doi: 10.1126/science.332.6037.1492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700846" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Databases, Factual ; Drug Industry ; *Drug Repositioning ; *National Institutes of Health (U.S.)/organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 85
    Publication Date: 2011-07-19
    Description: Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly neutralizing HIV antibodies that occur naturally have been characterized. To determine whether these antibodies are part of a larger group of related molecules, we cloned 576 new HIV antibodies from four unrelated individuals. All four individuals produced expanded clones of potent broadly neutralizing CD4-binding-site antibodies that mimic binding to CD4. Despite extensive hypermutation, the new antibodies shared a consensus sequence of 68 immunoglobulin H (IgH) chain amino acids and arise independently from two related IgH genes. Comparison of the crystal structure of one of the antibodies to the broadly neutralizing antibody VRC01 revealed conservation of the contacts to the HIV spike.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351836/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351836/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheid, Johannes F -- Mouquet, Hugo -- Ueberheide, Beatrix -- Diskin, Ron -- Klein, Florian -- Oliveira, Thiago Y K -- Pietzsch, John -- Fenyo, David -- Abadir, Alexander -- Velinzon, Klara -- Hurley, Arlene -- Myung, Sunnie -- Boulad, Farid -- Poignard, Pascal -- Burton, Dennis R -- Pereyra, Florencia -- Ho, David D -- Walker, Bruce D -- Seaman, Michael S -- Bjorkman, Pamela J -- Chait, Brian T -- Nussenzweig, Michel C -- P01 AI081677/AI/NIAID NIH HHS/ -- P30 AI060354/AI/NIAID NIH HHS/ -- R01 AI033292/AI/NIAID NIH HHS/ -- RR00862/RR/NCRR NIH HHS/ -- RR022220/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Sep 16;333(6049):1633-7. doi: 10.1126/science.1207227. Epub 2011 Jul 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764753" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies, Neutralizing/*chemistry/*immunology/metabolism ; Antibody Affinity ; Antibody Specificity ; Antigens, CD4/immunology/*metabolism ; Binding Sites ; Binding Sites, Antibody ; Cloning, Molecular ; Consensus Sequence ; Crystallography, X-Ray ; Genes, Immunoglobulin Heavy Chain ; HIV Antibodies/*chemistry/*immunology/metabolism ; HIV Envelope Protein gp120/chemistry/*immunology/metabolism ; HIV Infections/immunology ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Light Chains/chemistry ; Molecular Mimicry ; Molecular Sequence Data ; Mutation ; Protein Conformation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 86
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-04-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schellekens, Huub -- Moors, Ellen -- Leufkens, H G -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):174-5. doi: 10.1126/science.332.6026.174.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474737" target="_blank"〉PubMed〈/a〉
    Keywords: *Diffusion of Innovation ; *Drug Discovery ; *Drug and Narcotic Control ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 87
    Publication Date: 2011-02-26
    Description: The fire ant Solenopsis invicta is a significant pest that was inadvertently introduced into the southern United States almost a century ago and more recently into California and other regions of the world. An assessment of genetic variation at a diverse set of molecular markers in 2144 fire ant colonies from 75 geographic sites worldwide revealed that at least nine separate introductions of S. invicta have occurred into newly invaded areas and that the main southern U.S. population is probably the source of all but one of these introductions. The sole exception involves a putative serial invasion from the southern United States to California to Taiwan. These results illustrate in stark fashion a severe negative consequence of an increasingly massive and interconnected global trade and travel system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ascunce, Marina S -- Yang, Chin-Cheng -- Oakey, Jane -- Calcaterra, Luis -- Wu, Wen-Jer -- Shih, Cheng-Jen -- Goudet, Jerome -- Ross, Kenneth G -- Shoemaker, DeWayne -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1066-8. doi: 10.1126/science.1198734.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉USDA-ARS Center for Medical, Agricultural, and Veterinary Entomology, 1600/1700 Southwest 23rd Drive, Gainesville, FL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ants/genetics ; Asia ; Australia ; Bayes Theorem ; Commerce ; Computer Simulation ; DNA, Mitochondrial/genetics ; Female ; Genes, Insect ; Genetic Variation ; Genotype ; Haplotypes ; *Introduced Species ; Male ; Microsatellite Repeats ; Molecular Sequence Data ; Population Dynamics ; Sequence Analysis, DNA ; South America ; Travel ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 88
    Publication Date: 2011-02-19
    Description: Cotranslational targeting of membrane and secretory proteins is mediated by the universally conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates the guanine triphosphate (GTP)-dependent delivery of translating ribosomes bearing signal sequences to translocons on the target membrane. Here, we present the crystal structure of the SRP:SR complex at 3.9 angstrom resolution and biochemical data revealing that the activated SRP:SR guanine triphosphatase (GTPase) complex binds the distal end of the SRP hairpin RNA where GTP hydrolysis is stimulated. Combined with previous findings, these results suggest that the SRP:SR GTPase complex initially assembles at the tetraloop end of the SRP RNA and then relocalizes to the opposite end of the RNA. This rearrangement provides a mechanism for coupling GTP hydrolysis to the handover of cargo to the translocon.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758919/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758919/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ataide, Sandro F -- Schmitz, Nikolaus -- Shen, Kuang -- Ke, Ailong -- Shan, Shu-ou -- Doudna, Jennifer A -- Ban, Nenad -- GM078024/GM/NIGMS NIH HHS/ -- R01 GM078024/GM/NIGMS NIH HHS/ -- R01 GM086766/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):881-6. doi: 10.1126/science.1196473.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology and Biophysics, Eidgenossische Technische Hochschule Zurich (ETH Zurich), Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330537" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/*chemistry/metabolism ; Base Sequence ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Enzyme Activation ; Escherichia coli/chemistry/metabolism ; Escherichia coli Proteins/*chemistry/metabolism ; GTP Phosphohydrolases/chemistry/metabolism ; Guanosine Triphosphate/analogs & derivatives/chemistry/metabolism ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Biological ; Models, Molecular ; Nucleic Acid Conformation ; Protein Conformation ; Protein Multimerization ; Protein Structure, Tertiary ; Protein Transport ; RNA, Bacterial/*chemistry/metabolism ; Receptors, Cytoplasmic and Nuclear/*chemistry/metabolism ; Ribosomal Proteins/chemistry/metabolism ; Ribosomes/metabolism ; Signal Recognition Particle/*chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 89
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 May 6;332(6030):651. doi: 10.1126/science.332.6030.651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21551039" target="_blank"〉PubMed〈/a〉
    Keywords: Embryo Research/economics/*legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government/legislation & jurisprudence ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.)/economics/*legislation & jurisprudence ; Research Support as Topic/legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 90
    Publication Date: 2011-09-24
    Description: Savannas worldwide are vital for both socioeconomic and biodiversity values. In these ecosystems, management decisions are based on the perception that wildlife and livestock compete for food, yet there are virtually no experimental data to support this assumption. We examined the effects of wild African ungulates on cattle performance, food intake, and diet quality. Wild ungulates depressed cattle food intake and performance during the dry season (competition) but enhanced cattle diet quality and performance during the wet season (facilitation). These results extend our understanding of the context-dependent-competition-facilitation balance, in general, and are critical for better understanding and managing wildlife-livestock coexistence in human-occupied savanna landscapes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Odadi, Wilfred O -- Karachi, Moses K -- Abdulrazak, Shaukat A -- Young, Truman P -- New York, N.Y. -- Science. 2011 Sep 23;333(6050):1753-5. doi: 10.1126/science.1208468.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mpala Research Centre, Post Office Box 555, Nanyuki 10400, Kenya. woodadi@yahoo.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940896" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Wild/anatomy & histology/physiology ; Biodiversity ; Body Size ; Body Weight ; *Cattle/anatomy & histology/physiology ; Diet ; *Ecosystem ; Elephants/anatomy & histology/physiology ; Equidae/physiology ; *Feeding Behavior ; Food Chain ; Kenya ; Poaceae ; Ruminants/anatomy & histology/physiology ; Seasons
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 91
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):523. doi: 10.1126/science.332.6029.523.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527686" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/economics/*supply & distribution ; Clinical Trials as Topic ; *Drug Industry/economics/legislation & jurisprudence ; Drugs, Generic/economics/*supply & distribution ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 92
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atchley, William R -- New York, N.Y. -- Science. 2011 May 13;332(6031):804. doi: 10.1126/science.1207426.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA. bill@atchleylab.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566183" target="_blank"〉PubMed〈/a〉
    Keywords: *Evolution, Molecular ; History, 20th Century ; History, 21st Century ; Periodicals as Topic/history ; Societies, Scientific/history/organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 93
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schenkman, Lauren -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1002-4. doi: 10.1126/science.331.6020.1002.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350139" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Government Regulation ; Humans ; Neoplasms, Radiation-Induced/epidemiology/*etiology/mortality ; Practice Guidelines as Topic ; *Radiation Dosage ; Risk Factors ; Tomography Scanners, X-Ray Computed/*standards ; Tomography, X-Ray Computed/*adverse effects/standards ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 94
    Publication Date: 2011-01-29
    Description: Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the amino-terminal domain of SAS-6 from zebrafish, and we show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are probably essential to the structural organization of cartwheel centers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Breugel, Mark -- Hirono, Masafumi -- Andreeva, Antonina -- Yanagisawa, Haru-aki -- Yamaguchi, Shoko -- Nakazawa, Yuki -- Morgner, Nina -- Petrovich, Miriana -- Ebong, Ima-Obong -- Robinson, Carol V -- Johnson, Christopher M -- Veprintsev, Dmitry -- Zuber, Benoit -- MC_U105184294/Medical Research Council/United Kingdom -- MC_U105192716/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1196-9. doi: 10.1126/science.1199325. Epub 2011 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council-Laboratory of Molecular Biology (MRC-LMB), Hills Road, Cambridge, UK. vanbreug@mrc-lmb.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273447" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Animals ; Cell Cycle Proteins/chemistry/metabolism ; Cell Line, Tumor ; Centrioles/*chemistry/metabolism/ultrastructure ; Centrosome/metabolism ; Chlamydomonas reinhardtii/chemistry/metabolism ; Chromosomal Proteins, Non-Histone/*chemistry/metabolism ; Crystallography, X-Ray ; Flagella/metabolism/ultrastructure ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Mutant Proteins/chemistry ; Point Mutation ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry/metabolism ; Zebrafish ; Zebrafish Proteins/*chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 95
    Publication Date: 2011-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):389. doi: 10.1126/science.331.6016.389.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273461" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Antiviral Agents/pharmacology ; *Biological Specimen Banks ; *Biomedical Research ; Humans ; Russia ; *Smallpox/diagnosis/drug therapy/prevention & control ; Smallpox Vaccine ; United States ; *Variola virus/drug effects/genetics ; *World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 96
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohlemuller, Ralf -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):613-4. doi: 10.1126/science.1214215.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological and Biomedical Sciences, and Institute of Hazard, Risk and Resilience (IHRR), Durham University, Durham, DH1 3LE, UK. ralf.ohlemuller@durham.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053039" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Climate Change ; *Ecosystem
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 97
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Charles -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):812-3. doi: 10.1126/science.333.6044.812.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21835992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; *Ecosystem ; *Environment ; *Ice Cover ; Oceans and Seas ; *Petroleum ; United States ; Water Movements
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 98
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Jan 28;331(6016):386. doi: 10.1126/science.331.6016.386.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273458" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/economics/legislation & ; jurisprudence/*organization & administration ; Policy ; Translational Medical Research/economics/*organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 99
    Publication Date: 2011-04-30
    Description: The interaction of complement receptor 2 (CR2)--which is present on B cells and follicular dendritic cells--with its antigen-bound ligand C3d results in an enhanced antibody response, thus providing an important link between the innate and adaptive immune systems. Although a cocrystal structure of a complex between C3d and the ligand-binding domains of CR2 has been published, several aspects of this structure, including the position in C3d of the binding interface, remained controversial because of disagreement with biochemical data. We now report a cocrystal structure of a CR2(SCR1-2):C3d complex at 3.2 angstrom resolution in which the interaction interfaces differ markedly from the previously published structure and are consistent with the biochemical data. It is likely that, in the previous structure, the interaction was influenced by the presence of zinc acetate additive in the crystallization buffer, leading to a nonphysiological complex. Detailed knowledge of the binding interface now at hand gives the potential to exploit the interaction in vaccine design or in therapeutics directed against autoreactive B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Elsen, Jean M H -- Isenman, David E -- New York, N.Y. -- Science. 2011 Apr 29;332(6029):608-11. doi: 10.1126/science.1201954.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. bssjmhve@bath.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21527715" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Complement C3d/*chemistry/metabolism ; Crystallization ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Ligands ; Models, Molecular ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Receptors, Complement 3d/*chemistry/genetics/metabolism ; Zinc Acetate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 100
    Publication Date: 2011-01-08
    Description: NifEN plays an essential role in the biosynthesis of the nitrogenase iron-molybdenum (FeMo) cofactor (M cluster). It is an alpha(2)beta(2) tetramer that is homologous to the catalytic molybdenum-iron (MoFe) protein (NifDK) component of nitrogenase. NifEN serves as a scaffold for the conversion of an iron-only precursor to a matured form of the M cluster before delivering the latter to its target location within NifDK. Here, we present the structure of the precursor-bound NifEN of Azotobacter vinelandii at 2.6 angstrom resolution. From a structural comparison of NifEN with des-M-cluster NifDK and holo NifDK, we propose similar pathways of cluster insertion for the homologous NifEN and NifDK proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138709/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138709/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jens T -- Hu, Yilin -- Wiig, Jared A -- Rees, Douglas C -- Ribbe, Markus W -- GM-45162/GM/NIGMS NIH HHS/ -- GM-67626/GM/NIGMS NIH HHS/ -- R01 GM067626/GM/NIGMS NIH HHS/ -- R01 GM067626-09/GM/NIGMS NIH HHS/ -- R37 GM045162/GM/NIGMS NIH HHS/ -- R37 GM045162-22/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):91-4. doi: 10.1126/science.1196954.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Chemistry and Chemical Engineering, California Institute of Technology, Mail Code 114-96, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212358" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Azotobacter vinelandii/*chemistry/enzymology ; Bacterial Proteins/*chemistry/metabolism ; Crystallography, X-Ray ; Models, Molecular ; Molecular Sequence Data ; Molybdoferredoxin/*chemistry/metabolism ; Nitrogenase/*chemistry/metabolism ; Protein Multimerization ; Protein Precursors/chemistry/metabolism ; Protein Structure, Quaternary ; Protein Structure, Tertiary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...