Publication Date:
2011-11-15
Description:
With its high-energy phosphate bonds, adenosine triphosphate (ATP) is the main intracellular energy carrier. It also functions in most signaling pathways, as a phosphate donor or a precursor for cyclic adenosine monophosphate. We show here that inositol pyrophosphates participate in the control of intracellular ATP concentration. Yeasts devoid of inositol pyrophosphates have dysfunctional mitochondria but, paradoxically, contain four times as much ATP because of increased glycolysis. We demonstrate that inositol pyrophosphates control the activity of the major glycolytic transcription factor GCR1. Thus, inositol pyrophosphates regulate ATP concentration by altering the glycolytic/mitochondrial metabolic ratio. Metabolic reprogramming through inositol pyrophosphates is an evolutionary conserved mechanism that is also preserved in mammalian systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szijgyarto, Zsolt -- Garedew, Assegid -- Azevedo, Cristina -- Saiardi, Adolfo -- G1001704/Medical Research Council/United Kingdom -- MC_U122680443/Medical Research Council/United Kingdom -- PG/10/72/28449/British Heart Foundation/United Kingdom -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):802-5. doi: 10.1126/science.1211908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076377" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Diphosphate/metabolism
;
Adenosine Monophosphate/metabolism
;
Adenosine Triphosphate/*metabolism
;
DNA-Binding Proteins/chemistry/genetics/*metabolism
;
*Energy Metabolism
;
Gene Expression Regulation, Fungal
;
Glucose/metabolism
;
Glycolysis/genetics
;
Inositol Phosphates/*metabolism
;
Mitochondria/metabolism
;
Mutation
;
NAD/metabolism
;
Oxidation-Reduction
;
Oxidative Phosphorylation
;
Oxygen Consumption
;
Phosphorylation
;
Recombinant Fusion Proteins/metabolism
;
Saccharomyces cerevisiae/genetics/growth & development/*metabolism
;
Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism
;
Transcription Factors/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
