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  • 1
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Integrated manufacturing systems 13 (2002), S. 190-200 
    ISSN: 0957-6061
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Economics
    Notes: Since its inception, cost accounting has provided data to managers for the development of internal organizational performance measures. In the mid 1980s, Dr Eli Goldratt introduced a new management philosophy called the theory of constraints (TOC). This philosophy contained a new set of performance measures which linked together the strategic objectives and operational capabilities of the organization. This linkage allows for the maximization of profits. Since its introduction, there has been a growing amount of evidence documenting TOC's ability to more tightly link local decisions to organizational performance than those of traditional cost accounting. This research used a simple Gedunken experiment to evaluate the difference between strategy driven product-mix decisions based on TOC accounting and traditional cost accounting. In all cases, the constraint-based approach to costing outperformed the traditional approach based on cost accounting.
    Type of Medium: Electronic Resource
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  • 2
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    In:  J. Geophys. Res., Luxembourg, Am. Soc. Mech. Eng., vol. 89, no. 6, pp. 4344-4358, pp. L12311, (ISBN 0-471-26610-8)
    Publication Date: 1984
    Keywords: Geol. aspects ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Tectonics ; petrology ; JGR
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  • 3
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    In:  Geology, Luxembourg, Conseil de l'Europe, vol. 32, no. 9, pp. 813-816, pp. L09602, (ISSN: 1340-4202)
    Publication Date: 2004
    Keywords: Fluids ; Earthquake ; Aftershocks ; Physical properties of rocks ; Fracture
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  • 4
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    In:  J. Geophys. Res., Roma, Acad. Roy. des Sciences, vol. 100, no. 4, pp. 12841-12860, pp. B04102, (ISBN: 0-12-018847-3)
    Publication Date: 1995
    Keywords: Fluids ; Fracture ; JGR
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  • 5
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    In:  J. Geophys. Res., Leyden, Noordhoff International Publishing, vol. 106, no. B2, pp. 2235-2244, pp. B04306, (ISSN: 1340-4202)
    Publication Date: 2001
    Keywords: Hypocentral depth ; Seismology ; Strength ; Mohr ; Stress ; Stress drop ; 7209 ; Seismology ; Earthquake ; dynamics ; and ; mechanics ; 8010 ; Structural ; geology ; 8165 ; Fractures ; and ; faults ; 8045 ; Role ; of ; fluids ; 8164 ; Tectonophysics ; Stresses-crust ; and ; lithosphere ; JGR
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  • 6
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    In:  Earth planet. Sci. Lett., London, AGU, vol. 206, no. 1-2, pp. 161-172, pp. B02408, (ISSN: 1340-4202)
    Publication Date: 2003
    Keywords: Strength ; Fault zone ; Physical properties of rocks ; Fluids ; Stress ; Laboratory measurements ; EPSL
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  • 7
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    In:  J. Geophys. Res., London, AGU, vol. 111, no. B9, pp. 161-172, pp. B09202, (ISSN: 1340-4202)
    Publication Date: 2006
    Keywords: Rock mechanics ; Laboratory measurements ; Strength ; Fluids ; Friction ; pressure ; temperature ; activation ; energy ; JGR ; Physical properties of rocks ; Fracture ; faulting ; strength ; recovery ; cohesion ; 8163 ; Tectonophysics: ; Rheology ; and ; friction ; of ; fault ; zones ; (8034) ; 8010 ; Structural ; Geology: ; Fractures ; and ; faults ; 8045 ; Role ; of ; fluids ; 5199 ; Physical ; Properties ; of ; Rocks: ; General ; or ; miscellaneous ; 7230 ; Seismology: ; Seismicity ; and ; tectonics ; (1207, ; 1217, ; 1240, ; 1242)
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  • 8
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    In:  Journal of Structural Geology, Tokyo, Dt. Geophys. Ges., vol. 20, no. 12, pp. 1625-1640, pp. L06615, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Fault zone ; Stress ; Mining geophysics ; Fluids ; permeability ; Structural geology ; JSG
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  • 9
    Publication Date: 2015-11-20
    Description: Sexually selected traits are often driven to costly extremes by persistent directional selection. Energy acquisition and allocation can therefore influence variation in traits subject to both precopulatory and postcopulatory sexual selection, though the later have received much less attention. We tested the condition dependence of sperm morphology, sperm count, and fertilization success in a promiscuous lizard ( Anolis sagrei ) by 1) collecting sperm samples from wild males that varied naturally in body condition, 2) experimentally altering the body condition of captive males through dietary restriction, and 3) analyzing genetic paternity data from competitive mating trials between captive males that differed in body condition. In both wild and captive males, the length of the sperm midpiece decreased with body condition. Experimental food restriction decreased sperm production, decreased length of the sperm head, increased length of the sperm midpiece, and increased variance in sperm morphology within individuals. When restricted to a single copulation, males on high-intake diets exhibited a slight but nonsignificant fertilization advantage. Reanalysis of a previous experiment in which high- and low-condition males were sequentially allowed to copulate ad libitum for 1 week revealed a significant fertilization bias in favor of high-condition males. When controlling for mean treatment effects on the proportion of offspring sired and on sperm phenotypes, multiple regression revealed negative correlations between fertilization success and sperm head length, midpiece length, and sperm count. Collectively, our results suggest that condition-dependent fertilization success in A. sagrei may be partially mediated by underlying condition dependence of sperm morphology and sperm count.
    Print ISSN: 1045-2249
    Electronic ISSN: 1465-7279
    Topics: Biology
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  • 10
    Publication Date: 2016-02-02
    Description: Motivation: Phosphoproteomics measurements are widely applied in cellular biology to detect changes in signalling dynamics. However, due to the inherent complexity of phosphorylation patterns and the lack of knowledge on how phosphorylations are related to functions, it is often not possible to directly deduce protein activities from those measurements. Here, we present a heuristic machine learning algorithm that infers the activities of kinases from Phosphoproteomics data using kinase–target information from the PhosphoSitePlus database. By comparing the estimated kinase activity profiles to the measured phosphosite profiles, it is furthermore possible to derive the kinases that are most likely to phosphorylate the respective phosphosite. Results: We apply our approach to published datasets of the human cell cycle generated from HeLaS3 cells, and insulin signalling dynamics in mouse hepatocytes. In the first case, we estimate the activities of 118 at six cell cycle stages and derive 94 new kinase–phosphosite links that can be validated through either database or motif information. In the second case, the activities of 143 kinases at eight time points are estimated and 49 new kinase–target links are derived. Availability and implementation: The algorithm is implemented in Matlab and be downloaded from github. It makes use of the Optimization and Statistics toolboxes. https://github.com/marcel-mischnik/IKAP.git . Contact: marcel.mischnik@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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