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  • 1
    Monograph available for loan
    Monograph available for loan
    Boston [u.a.] : Unwin Hyman
    Call number: M 555
    Type of Medium: Monograph available for loan
    Pages: XIV, 146 S. : Ill., graph. Darst.
    ISBN: 0045220267
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Publication Date: 2012-08-01
    Description: The Okanagan Valley shear zone delineates the SW margin of the Shuswap metamorphic complex, the largest core complex within the North American Cordillera. The Okanagan Valley shear zone is a major Eocene extensional fault zone that facilitated exhumation of the southern Shuswap metamorphic complex during the orogenic collapse of the SE Canadian Cordillera when convergence at the western margin of North America switched from transpression to transtension. This study documents the petrology, structure, and age of the Okanagan gneiss, the main lithology within the footwall of the Okanagan Valley shear zone, and constrains its history from protolith to exhumed shear zone.The Okanagan gneiss is an ~1.5-km-thick, west-dipping panel composed of intercalated orthogneiss and paragneiss in which intense ductile deformation of the Okanagan Valley shear zone is recorded. New U-Pb zircon ages from the gneiss and crosscutting intrusions constrain the development of the Okanagan gneiss to the Eocene, contemporaneous with widespread extension, intense deformation, high-grade metamorphism, and anatexis in the southern Canadian Cordillera. Thermobarometric data from the paragneiss domain indicate Eocene exhumation from between 17 and 23 km depth, which implies 64–89 km of WNW-directed horizontal extension based on an original shear zone angle of ~15°. Neither the Okanagan gneiss nor its protolith represents exhumed Proterozoic North American cratonic basement as previously postulated. New U-Pb data demonstrate that the protolith for the gneiss is Phanerozoic, consisting of Mesozoic intrusions emplaced within a late Paleozoic–Mesozoic layered sequence of sedimentary rocks.
    Print ISSN: 1941-8264
    Electronic ISSN: 1947-4253
    Topics: Geosciences
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  • 3
    Publication Date: 2014-12-17
    Description: Time contained within coal seams is most commonly estimated using a volumetric approach that fails to take into account processes of carbon accumulation and loss during peat formation and coalification. A more appropriate approach for estimating the time contained within a coal seam is to use Holocene long-term carbon accumulation rates, accounting for carbon loss during coalification. Using this approach the thickness of coal corresponding to 10 kyr of carbon accumulation is calculated for coals of all ranks and latitudinal settings. To test the validity of this approach, latitudinal patterns of Holocene dust deposition are used in conjunction with estimated rates of carbon accumulation to calculate the concentration of titanium in coal. The result is a statistically significant correlation that is optimized when latitudinal variation in carbon accumulation rate is considered. Overall, the use of carbon produces far greater accountability of time within coal-bearing stratigraphic sequences and is not influenced by the presence of hiatal surfaces within the coal. Estimated coal seam duration increases considerably, often removing the need to infer substantial intra-seam hiatuses. On the basis of the results, a re-evaluation of coal and coal-bearing stratigraphic sequences is recommended.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 4
    Publication Date: 2014-04-18
    Description: Rare copy number variants (CNVs) disrupting ASTN2 or both ASTN2 and TRIM32 have been reported at 9q33.1 by genome-wide studies in a few individuals with neurodevelopmental disorders (NDDs). The vertebrate-specific astrotactins, ASTN2 and its paralog ASTN1 , have key roles in glial-guided neuronal migration during brain development. To determine the prevalence of astrotactin mutations and delineate their associated phenotypic spectrum, we screened ASTN2/TRIM32 and ASTN1 (1q25.2) for exonic CNVs in clinical microarray data from 89 985 individuals across 10 sites, including 64 114 NDD subjects. In this clinical dataset, we identified 46 deletions and 12 duplications affecting ASTN2 . Deletions of ASTN1 were much rarer. Deletions near the 3' terminus of ASTN2 , which would disrupt all transcript isoforms (a subset of these deletions also included TRIM32 ), were significantly enriched in the NDD subjects ( P = 0.002) compared with 44 085 population-based controls. Frequent phenotypes observed in individuals with such deletions include autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), speech delay, anxiety and obsessive compulsive disorder (OCD). The 3'-terminal ASTN2 deletions were significantly enriched compared with controls in males with NDDs, but not in females. Upon quantifying ASTN2 human brain RNA, we observed shorter isoforms expressed from an alternative transcription start site of recent evolutionary origin near the 3' end. Spatiotemporal expression profiling in the human brain revealed consistently high ASTN1 expression while ASTN2 expression peaked in the early embryonic neocortex and postnatal cerebellar cortex. Our findings shed new light on the role of the astrotactins in psychopathology and their interplay in human neurodevelopment.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2011-07-23
    Description: Many physiological responses in present-day coral reefs to climate change are interpreted as consistent with the imminent disappearance of modern reefs globally because of annual mass bleaching events, carbonate dissolution, and insufficient time for substantial evolutionary responses. Emerging evidence for variability in the coral calcification response to acidification, geographical variation in bleaching susceptibility and recovery, responses to past climate change, and potential rates of adaptation to rapid warming supports an alternative scenario in which reef degradation occurs with greater temporal and spatial heterogeneity than current projections suggest. Reducing uncertainty in projecting coral reef futures requires improved understanding of past responses to rapid climate change; physiological responses to interacting factors, such as temperature, acidification, and nutrients; and the costs and constraints imposed by acclimation and adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pandolfi, John M -- Connolly, Sean R -- Marshall, Dustin J -- Cohen, Anne L -- New York, N.Y. -- Science. 2011 Jul 22;333(6041):418-22. doi: 10.1126/science.1204794.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Research Council (ARC) Centre of Excellence for Coral Reef Studies, St. Lucia, Queensland 4072, Australia. j.pandolfi@uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21778392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa/physiology ; Biodiversity ; Biological Evolution ; Calcification, Physiologic ; Carbon Dioxide/analysis ; Conservation of Natural Resources ; *Ecosystem ; Forecasting ; *Global Warming ; Hydrogen-Ion Concentration ; Oceans and Seas ; Seawater/*chemistry ; Symbiosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2015-08-01
    Description: An HIV-1 DNA prime vaccine, with a recombinant adenovirus type 5 (rAd5) boost, failed to protect from HIV-1 acquisition. We studied the nature of the vaccine-induced antibody (Ab) response to HIV-1 envelope (Env). HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41. Vaccine-induced gp41-reactive monoclonal antibodies were non-neutralizing and frequently polyreactive with host and environmental antigens, including intestinal microbiota (IM). Next-generation sequencing of an immunoglobulin heavy chain variable region repertoire before vaccination revealed an Env-IM cross-reactive Ab that was clonally related to a subsequent vaccine-induced gp41-reactive Ab. Thus, HIV-1 Env DNA-rAd5 vaccine induced a dominant IM-polyreactive, non-neutralizing gp41-reactive Ab repertoire response that was associated with no vaccine efficacy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562404/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562404/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, Wilton B -- Liao, Hua-Xin -- Moody, M Anthony -- Kepler, Thomas B -- Alam, S Munir -- Gao, Feng -- Wiehe, Kevin -- Trama, Ashley M -- Jones, Kathryn -- Zhang, Ruijun -- Song, Hongshuo -- Marshall, Dawn J -- Whitesides, John F -- Sawatzki, Kaitlin -- Hua, Axin -- Liu, Pinghuang -- Tay, Matthew Z -- Seaton, Kelly E -- Shen, Xiaoying -- Foulger, Andrew -- Lloyd, Krissey E -- Parks, Robert -- Pollara, Justin -- Ferrari, Guido -- Yu, Jae-Sung -- Vandergrift, Nathan -- Montefiori, David C -- Sobieszczyk, Magdalena E -- Hammer, Scott -- Karuna, Shelly -- Gilbert, Peter -- Grove, Doug -- Grunenberg, Nicole -- McElrath, M Juliana -- Mascola, John R -- Koup, Richard A -- Corey, Lawrence -- Nabel, Gary J -- Morgan, Cecilia -- Churchyard, Gavin -- Maenza, Janine -- Keefer, Michael -- Graham, Barney S -- Baden, Lindsey R -- Tomaras, Georgia D -- Haynes, Barton F -- P30 AI064518/AI/NIAID NIH HHS/ -- P30-AI-64518/AI/NIAID NIH HHS/ -- U01 AI069412/AI/NIAID NIH HHS/ -- UM1 AI068614/AI/NIAID NIH HHS/ -- UM1 AI068618/AI/NIAID NIH HHS/ -- UM1 AI068635/AI/NIAID NIH HHS/ -- UM1 AI069412/AI/NIAID NIH HHS/ -- UM1 AI069470/AI/NIAID NIH HHS/ -- UM1 AI069481/AI/NIAID NIH HHS/ -- UM1 AI069511/AI/NIAID NIH HHS/ -- UM1 AI100645/AI/NIAID NIH HHS/ -- UM1AI068618/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2015 Aug 14;349(6249):aab1253. doi: 10.1126/science.aab1253. Epub 2015 Jul 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA. barton.haynes@duke.edu wilton.williams@duke.edu. ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA. ; Department of Microbiology, Boston University School of Medicine, Boston, MA, USA. ; Department of Medicine, Columbia University Medical Center, New York, NY, USA. ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ; The Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ; The Aurum Institute, Johannesburg, South Africa. ; University of Rochester School of Medicine, Rochester, NY, USA. ; Brigham and Women's Hospital, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26229114" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; Adenoviridae ; Antibodies, Monoclonal/genetics/immunology ; Antibody Formation ; Cross Reactions ; HIV Antibodies/genetics/*immunology ; HIV Envelope Protein gp120/immunology ; HIV Envelope Protein gp41/genetics/*immunology ; HIV-1/*immunology ; Humans ; Immunity ; Immunoglobulin Heavy Chains/genetics/immunology ; Immunoglobulin Variable Region/genetics/immunology ; Immunologic Memory ; Intestines/microbiology ; Microbiota/*immunology ; Vaccines, DNA/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 9 (1966), S. 513-516 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 1359-1359 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In electron probe microanalysis the characteristic lines are separated by Bragg reflexion in a crystal spectrometer and elements above magnesium in the periodic table can usually be identified. The use of electrons to excite the specimen has certain other advantages. The incident electrons can be ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2056
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sixty species of Acari are recorded from the sub-Antarctic Marion and Prince Edward Islands (the Prince Edward archipelago). Twenty of the 45 species collected on recent expeditions are new and currently undescribed. Other new taxa include a family of Mesostigmata, four new genera, and the first sub-Antarctic records of Cillibidae (Mesostigmata) and Eryngiopus (Prostigmata). Fifteen of the 31 species previously reported from the islands are confirmed, although eight of the previous accounts remain doubtful. The fauna, which shows a distinction between the shoreline and terrestrial components, comprises endemic, South Indian Ocean Province and sub-Antarctic mite species.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Polar biology 16 (1996), S. 287-292 
    ISSN: 1432-2056
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Water availability, in addition to cold, is important in limiting biotic distribution in the Antarctic regions. In general, inland continental Antarctic habitats are dry, relative to maritime and sub-Antarctic habitats. This investigation compares the water relations of an endemic continental Antarctic oribatid mite, Maudheimia petronia Wallwork, and two sub-Antarctic oribatid mites, Halozetes fulvus Engelbrecht and Podacarus auberti Grandjean. M. petronia showed enhanced survival of dehydrating conditions, which may be attributable to both its greater resistance to and tolerance of water loss. The estimated lethal exposure times (LT50) for M. petronia, P. auberti and H. fulvus held at 15°C and 0–5% RH were 250, 135 and 51 h, respectively. M. petronia lost water significantly more slowly than the sub-Antarctic mites (P〈0.05), which did not differ in their rates of water loss (P〉0.05). The mean losses of initial body water content after 45 h were 18.9, 27.3 and 29.3% for M. petronia, P. auberti and H. fulvus, respectively, and lethal water losses causing 50% of the sample to die were 65, 52, and 28%, respectively. These data suggest physiological adaptation by M. petronia for existence in periodically dry “chalikosystem” habitats at Antarctic nunataks. Comparisons of tolerance of submersion in freshwater showed P. auberti to be superior to M. petronia; the LT50 values for submersion were 〉146 h and 32 h, respectively. Tolerance of submersion by P. auberti may be important for its existence in wet sub-Antarctic habitats. Conversely, the poor tolerance shown by M. petronia suggests that this mite has not been associated with moist environments.
    Type of Medium: Electronic Resource
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