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  • Humans  (1.108)
  • United States  (303)
  • Models, Molecular  (108)
  • American Association for the Advancement of Science (AAAS)  (1.344)
  • Institute of Physics
  • 1995-1999  (1.344)
  • 1996  (679)
  • 1995  (665)
Sammlung
Schlagwörter
Verlag/Herausgeber
  • American Association for the Advancement of Science (AAAS)  (1.344)
  • Institute of Physics
  • Springer  (4)
Erscheinungszeitraum
  • 1995-1999  (1.344)
Jahr
  • 101
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    Arguing over why Johnny can't read (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):1896-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701312" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Child ; Chromosomes, Human, Pair 6 ; Dyslexia/diagnosis/epidemiology/*etiology ; Female ; Humans ; Learning Disorders/diagnosis/epidemiology/*etiology ; Magnetic Resonance Imaging ; Male ; National Institutes of Health (U.S.) ; Thalamus/*pathology/physiopathology/*radionuclide imaging ; Tomography, Emission-Computed ; United States/epidemiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 102
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    Sterkfontein member 2 foot bones of the oldest South African hominid (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-28
    Beschreibung: Four articulating hominid foot bones have been recovered from Sterkfontein Member 2, near Johannesburg, South Africa. They have human features in the hindfoot and strikingly apelike traits in the forefoot. While the foot is manifestly adapted for bipedalism, its most remarkable characteristic is that the great toe (hallux) is appreciably medially diverged (varus) and strongly mobile, as in apes. Possibly as old as 3.5 million years, the foot provides the first evidence that bipedal hominids were in southern Africa more than 3.0 million years ago. The bones probably belonged to an early member of Australopithecus africanus or another early hominid species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clarke, R J -- Tobias, P V -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):521-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Human Biology, University of the Witwatersrand Medical School, Johannesburg, South Africa.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624772" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Evolution ; Foot/*anatomy & histology ; *Fossils ; Hallux/anatomy & histology ; History, Ancient ; Hominidae/*anatomy & histology/physiology ; Humans ; *Locomotion ; Metatarsal Bones/anatomy & histology ; South Africa ; Talus/anatomy & histology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 103
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    "The Duesberg phenomenon": Duesberg and other voices (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cline, F A Jr -- New York, N.Y. -- Science. 1995 Jan 20;267(5196):314-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824921" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/drug therapy/*virology ; HIV/pathogenicity ; Homosexuality, Male ; Humans ; Male ; Research ; Zidovudine/*therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 104
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    AIDS-associated Kaposi's sarcoma. "Duesberg phenomenon' (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ascher, M S -- Sheppard, H W -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7726989" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/chemically induced/*etiology ; Humans ; Male ; Street Drugs/*adverse effects ; Zidovudine/adverse effects/therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 105
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    Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: RNA encoding the B subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of ionotropic glutamate receptor (GluR-B) undergoes a posttranscriptional modification in which a genomically encoded adenosine is represented as a guanosine in the GluR-B complementary DNA. In vitro editing of GluR-B RNA transcripts with HeLa cell nuclear extracts was found to result from an activity that converts adenosine to inosine in regions of double-stranded RNA by enzymatic base modification. This activity is consistent with that of a double-stranded RNA-specific adenosine deaminase previously described in Xenopus oocytes and widely distributed in mammalian tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rueter, S M -- Burns, C M -- Coode, S A -- Mookherjee, P -- Emeson, R B -- ES00267/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1491-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine/*metabolism ; Animals ; Base Sequence ; Cell Line ; Codon ; Exons ; HeLa Cells ; Humans ; Inosine/*metabolism ; Inosine Monophosphate/metabolism ; Mice ; Molecular Sequence Data ; *RNA Editing ; RNA Precursors/metabolism ; RNA, Double-Stranded/metabolism ; Rats ; Receptors, AMPA/*genetics ; Repetitive Sequences, Nucleic Acid ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 106
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    Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-27
    Beschreibung: TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). The TAFs in TFIID are essential for activator-dependent transcription. The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described. TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain. The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110. Thus, this human TFIID TAF may be a co-activator that mediates a response to multiple activators through a distinct mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiang, C M -- Roeder, R G -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):531-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824954" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenovirus E1A Proteins/metabolism ; Amino Acid Sequence ; Base Sequence ; Cloning, Molecular ; DNA-Binding Proteins/metabolism ; Erythroid-Specific DNA-Binding Factors ; Gene Products, tat/metabolism ; HeLa Cells ; Humans ; Molecular Sequence Data ; Sp1 Transcription Factor/chemistry/metabolism ; *TATA-Binding Protein Associated Factors ; TATA-Box Binding Protein ; Trans-Activators/chemistry/genetics/*metabolism ; Transcription Factor TFIID ; Transcription Factors/*chemistry/*metabolism ; Upstream Stimulatory Factors ; YY1 Transcription Factor
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 107
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    Play ball! (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chodosh, L A -- Lifson, L E -- Tabin, C -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1682-3; author reply 1683-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792585" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Baseball ; Humans ; *Motion Perception ; *Psychomotor Performance ; *Space Perception
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 108
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    Crystal structure of lac repressor core tetramer and its implications for DNA looping (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: The crystal structure of the tryptic core fragment of the lac repressor of Escherichia coli (LacR) complexed with the inducer isopropyl-beta-D-thiogalactoside was determined at 2.6 A resolution. The quaternary structure consists of two dyad-symmetric dimers that are nearly parallel to each other. This structure places all four DNA binding domains of intact LacR on the same side of the tetramer, and results in a deep, V-shaped cleft between the two dimers. Each monomer contributes a carboxyl-terminal helix to an antiparallel four-helix bundle that functions as a tetramerization domain. Some of the side chains whose mutation reduce DNA binding form clusters on a surface near the amino terminus. Placing the structure of the DNA binding domain complexed with operator previously determined by nuclear magnetic resonance onto this surface results in two operators being adjacent and nearly parallel to each other. Structural considerations suggest that the two dimers of LacR may flexibly alter their relative orientation in order to bind to the known varied spacings between two operators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman, A M -- Fischmann, T O -- Steitz, T A -- GM22778/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1721-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792597" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Crystallography, X-Ray ; DNA, Bacterial/*chemistry/metabolism ; Isopropyl Thiogalactoside/metabolism ; Models, Molecular ; *Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Repressor Proteins/*chemistry/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 109
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    Scientists attacked for 'patenting' Pacific tribe (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1112.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502030" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cell Line ; *Ethnic Groups/genetics ; Genes ; *Genetic Diseases, Inborn ; *Genetic Research ; *Human T-lymphotropic virus 1 ; Humans ; Information Dissemination ; Internationality ; Papua New Guinea ; *Patents as Topic ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 110
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    Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-02-24
    Beschreibung: The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive human malignant glioma M059J cell line was found to be defective in DNA double-strand break repair, but fails to express the p350 subunit of DNA-PK. These results suggest that DNA-PK kinase activity is involved in DNA double-strand break repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lees-Miller, S P -- Godbout, R -- Chan, D W -- Weinfeld, M -- Day, R S 3rd -- Barron, G M -- Allalunis-Turner, J -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1183-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Science, University of Calgary, Alberta, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7855602" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; *Antigens, Nuclear ; CHO Cells ; Cell Line, Transformed ; Cricetinae ; DNA/metabolism ; *DNA Helicases ; *DNA Repair ; DNA-Activated Protein Kinase ; DNA-Binding Proteins/analysis ; Gamma Rays ; Humans ; Molecular Sequence Data ; Nuclear Proteins/analysis ; Protein-Serine-Threonine Kinases/*metabolism ; *Radiation Tolerance ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 111
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    Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation. Oligomerization appears to be essential for the tumor suppressing activity of p53 because oligomerization-deficient p53 mutants cannot suppress the growth of carcinoma cell lines. The crystal structure of the tetramerization domain of p53 (residues 325 to 356) was determined at 1.7 angstrom resolution and refined to a crystallographic R factor of 19.2 percent. The monomer, which consists of a beta strand and an alpha helix, associates with a second monomer across an antiparallel beta sheet and an antiparallel helix-helix interface to form a dimer. Two of these dimers associate across a second and distinct parallel helix-helix interface to form the tetramer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, P D -- Gorina, S -- Pavletich, N P -- CA08748-29/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1498-502.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878469" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Computer Graphics ; Crystallography, X-Ray ; DNA/metabolism ; Hydrogen Bonding ; Macromolecular Substances ; Models, Molecular ; *Protein Conformation ; Protein Structure, Secondary ; Tumor Suppressor Protein p53/*chemistry/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 112
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    "Fat hormone" poses hefty problem for journal embargo (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Aug 4;269(5224):627.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624787" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Drug Industry/*economics ; Humans ; Leptin ; Mice ; Obesity/*drug therapy ; *Periodicals as Topic ; Proteins/*pharmacology ; *Publishing ; Weight Loss/drug effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 113
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    Alzheimer tangles and abnormal phosphorylation (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingram, V M -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):1889-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7741944" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Alzheimer Disease/*metabolism ; Humans ; Neurofibrillary Tangles/*metabolism ; Phosphorylation ; Protein Kinases/metabolism ; tau Proteins/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 114
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    Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-17
    Beschreibung: A member of the inwardly rectifying potassium channel family was cloned here. The channel, called BIR (Kir6.2), was expressed in large amounts in rat pancreatic islets and glucose-responsive insulin-secreting cell lines. Coexpression with the sulfonylurea receptor SUR reconstituted an inwardly rectifying potassium conductance of 76 picosiemens that was sensitive to adenosine triphosphate (ATP) (IKATP) and was inhibited by sulfonylureas and activated by diazoxide. The data indicate that these pancreatic beta cell potassium channels are a complex composed of at least two subunits--BIR, a member of the inward rectifier potassium channel family, and SUR, a member of the ATP-binding cassette superfamily. Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Inagaki, N -- Gonoi, T -- Clement, J P 4th -- Namba, N -- Inazawa, J -- Gonzalez, G -- Aguilar-Bryan, L -- Seino, S -- Bryan, J -- DK44311/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1166-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Medicine, Chiba University School of Medicine, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502040" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *ATP-Binding Cassette Transporters ; Adenosine Triphosphate/pharmacology ; Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Cloning, Molecular ; Cricetinae ; Diazoxide/pharmacology ; Humans ; Islets of Langerhans/metabolism ; KATP Channels ; Mice ; Molecular Sequence Data ; Potassium/*metabolism ; Potassium Channels/*chemistry/genetics/*metabolism ; *Potassium Channels, Inwardly Rectifying ; Rats ; Receptors, Drug/*chemistry/metabolism ; Rubidium/metabolism ; Sulfonylurea Compounds/pharmacology ; Sulfonylurea Receptors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 115
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    Malathion and alternatives (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chrisman, M -- Kurtz, P -- Dewell, R V -- New York, N.Y. -- Science. 1995 Aug 18;269(5226):907-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638607" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; California ; Humans ; *Insecticides ; Malathion/*adverse effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 116
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    Interhelical angles in the solution structure of the oligomerization domain of p53: correction (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clore, G M -- Omichinski, J G -- Sakaguchi, K -- Zambrano, N -- Sakamoto, H -- Appella, E -- Gronenborn, A M -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1515-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878474" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Crystallography, X-Ray ; Macromolecular Substances ; Magnetic Resonance Spectroscopy ; Models, Molecular ; *Protein Conformation ; Protein Structure, Secondary ; Tumor Suppressor Protein p53/*chemistry
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    "The Duesberg phenomenon": what does it mean? (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews, C -- New York, N.Y. -- Science. 1995 Jan 13;267(5195):157.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809613" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*etiology ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 118
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    Common mechanisms of visual imagery and perception (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: Detection of a visual target can be facilitated by flanking visual masks. A similar enhancement in detection thresholds was obtained when observers imagined the previously perceived masks. Imagery-induced facilitation was detected for as long as 5 minutes after observation of the masks by the targeted eye. These results indicated the existence of a low-level (monocular) memory that stores the sensory trace for several minutes and enables reactivation of early representations by higher processes. This memory, with its iconic nature, may subserve the interface between mental images and percepts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishai, A -- Sagi, D -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1772-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792605" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Eidetic Imagery/*physiology ; Humans ; Memory/*physiology ; Perceptual Masking ; Visual Cortex/physiology ; *Visual Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 119
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    Floyd Bloom: the next editor-in-chief of Science (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lerner, R A -- Guillemin, R -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1441-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878461" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administrative Personnel ; History, 20th Century ; Neuropharmacology/history ; *Periodicals as Topic/history ; *Science/history ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 120
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    A morbillivirus that caused fatal disease in horses and humans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-07
    Beschreibung: A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, K -- Selleck, P -- Hooper, P -- Hyatt, A -- Gould, A -- Gleeson, L -- Westbury, H -- Hiley, L -- Selvey, L -- Rodwell, B -- New York, N.Y. -- Science. 1995 Apr 7;268(5207):94-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701348" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Amino Acid Sequence ; Animals ; Base Sequence ; Cercopithecus aethiops ; Disease Outbreaks/*veterinary ; Female ; Horse Diseases/epidemiology/mortality/*virology ; Horses ; Humans ; Kidney/virology ; Lung/virology ; Male ; Middle Aged ; Molecular Sequence Data ; Morbillivirus/genetics/*isolation & purification ; Morbillivirus Infections/epidemiology/mortality/*veterinary/*virology ; Pregnancy ; Queensland/epidemiology ; Respiratory Tract Infections/veterinary/virology ; Spleen/virology ; Vero Cells ; Virus Cultivation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 121
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    Dana-Farber death sends a warning to research hospitals (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):295-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618095" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Academies and Institutes/standards ; Boston ; Breast Neoplasms/drug therapy ; Cancer Care Facilities/*standards ; Clinical Protocols/*standards ; Clinical Trials as Topic/standards ; Cyclophosphamide/adverse effects ; Drug Overdose ; Fatal Outcome ; Female ; Humans ; *Medication Errors ; Medication Systems, Hospital/*standards
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 122
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    Cell movement tale told by bacterial tail protein (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):30-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/*metabolism ; Animals ; Bacterial Proteins ; Bacterial Vaccines/immunology ; Cell Movement/*physiology ; DNA-Binding Proteins/*genetics/physiology ; Escherichia coli/genetics/physiology ; Genes, Bacterial ; Humans ; Macaca mulatta ; Mutation ; Shigella flexneri/genetics/immunology/*physiology ; Transcription Factors/*genetics/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 123
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    AIDS research. New drug shows promise in monkeys (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1121-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502035" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenine/*analogs & derivatives/pharmacology/therapeutic use ; Animals ; Antiviral Agents/pharmacology/*therapeutic use ; HIV/drug effects ; HIV Infections/drug therapy/*prevention & control/transmission ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Macaca fascicularis ; *Organophosphonates ; Organophosphorus Compounds/pharmacology/*therapeutic use ; Reverse Transcriptase Inhibitors/pharmacology/*therapeutic use ; Simian Acquired Immunodeficiency Syndrome/drug therapy/*prevention & control ; Simian Immunodeficiency Virus/drug effects ; Tenofovir
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 124
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    Use of placebo controls in clinical trials disputed (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):25-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809605" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Codes of Ethics ; *Control Groups ; Controlled Clinical Trials as Topic/*methods ; Ethical Review ; *Ethicists ; Ethics Committees, Research ; *Ethics, Medical ; Federal Government ; Government Regulation ; Humans ; Informed Consent ; *Placebos ; Research Subjects ; Risk Assessment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 125
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    Activation of dual T cell signaling pathways by the chemokine RANTES (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-22
    Beschreibung: The chemokine RANTES induced biphasic mobilization of Ca2+ in T cells. The initial peak, a transient increase in cytosolic Ca2+ mediated by a heterotrimeric guanine nucleotide-binding protein (G protein)--coupled pathway, was associated predominantly with chemotaxis. The second peak, Ca2+ release and sustained influx dependent on protein tyrosine kinases, was associated with a spectrum of cellular responses--Ca2+ channel opening, interleukin-2 receptor expression, cytokine release, and T cell proliferation--characteristic of T cell receptor activation. Other chemokines did not produce these responses. Thus, in addition to inducing chemotaxis, RANTES can act as an antigen-independent activator of T cells in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacon, K B -- Premack, B A -- Gardner, P -- Schall, T J -- GM07065/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1727-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569902" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, CD3/immunology ; Benzoquinones ; Calcium/*metabolism ; Calcium Channels/metabolism ; Chemokine CCL5/*pharmacology ; Chemotaxis, Leukocyte ; Clone Cells ; Cytokines/metabolism ; GTP-Binding Proteins/metabolism ; Humans ; Lactams, Macrocyclic ; Lymphocyte Activation ; Patch-Clamp Techniques ; Phytohemagglutinins/pharmacology ; Protein-Tyrosine Kinases/metabolism ; Quinones/pharmacology ; Receptors, Cytokine/metabolism ; Receptors, Interleukin-2/metabolism ; Rifabutin/analogs & derivatives ; *Signal Transduction ; T-Lymphocytes/immunology/metabolism/*physiology ; Virulence Factors, Bordetella/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 126
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    Thailand weighs AIDS vaccine tests (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):904-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481784" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *AIDS Vaccines/immunology ; Acquired Immunodeficiency Syndrome/*prevention & control ; Animals ; *Clinical Trials as Topic/economics ; Cohort Studies ; Costs and Cost Analysis ; Female ; HIV/classification ; HIV Antibodies/biosynthesis ; *HIV Envelope Protein gp120/immunology ; HIV Infections/*prevention & control ; Humans ; International Cooperation ; Male ; Pan troglodytes ; Patient Selection ; Thailand ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 127
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    AIDS-associated Kaposi's sarcoma (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, J L -- Hanson, D L -- Chu, S Y -- Ward, J W -- Jaffe, H W -- New York, N.Y. -- Science. 1995 Feb 24;267(5201):1078-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7855583" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS-Related Opportunistic Infections/drug therapy/virology ; Acquired Immunodeficiency Syndrome/*complications/drug therapy ; Acyclovir/therapeutic use ; Female ; Foscarnet/*therapeutic use ; Ganciclovir/therapeutic use ; Herpesviridae Infections/drug therapy/virology ; Humans ; Male ; Retrospective Studies ; Risk Factors ; Sarcoma, Kaposi/*complications/drug therapy/virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 128
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    Protein proves to be a key link in innate immunity (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, C -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):301-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618098" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carrier Proteins/chemistry/genetics/*immunology ; Child ; Cloning, Molecular ; Complement Activation/*immunology ; Disease Susceptibility ; Humans ; *Immunity, Innate ; Immunologic Deficiency Syndromes/*etiology ; Mannose-Binding Lectins ; Mutation ; Phagocytosis/*immunology ; Protein Conformation ; Protein Structure, Secondary
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 129
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    Differences in HIV strains may underlie disease patterns (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Oct 6;270(5233):30-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Developed Countries ; Developing Countries ; Female ; HIV Infections/epidemiology/transmission/*virology ; HIV-1/classification/growth & development/*pathogenicity ; Humans ; Langerhans Cells/*virology ; Male ; Thailand/epidemiology ; Vagina/virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 130
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    Researchers air alternative views on how HIV kills cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1044-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*immunology/therapy/virology ; Apoptosis ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/*immunology/virology ; CD8-Positive T-Lymphocytes/immunology ; HIV/*pathogenicity ; Humans ; Lymphocyte Count
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 131
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    Chiba's heavy-ion accelerator battles cancer and critics (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-05-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, D -- New York, N.Y. -- Science. 1995 May 12;268(5212):797-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754363" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Clinical Trials as Topic ; Humans ; Japan ; Neoplasms/*radiotherapy ; Radiotherapy, High-Energy/economics ; Research Support as Topic ; *Synchrotrons/economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 132
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    From genome to proteome: looking at a cell's proteins (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahn, P -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):369-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569989" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacterial Proteins/analysis/chemistry/genetics ; Computer Communication Networks ; Databases, Factual ; *Electrophoresis, Gel, Two-Dimensional ; Escherichia coli/chemistry/genetics ; Fungal Proteins/analysis/chemistry/genetics ; Genes, Fungal ; Humans ; Mass Spectrometry/*methods ; Proteins/*analysis/chemistry/genetics ; Saccharomyces cerevisiae/chemistry/genetics ; Software
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 133
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    Share and share alike isn't always the rule in science (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1715-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792594" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Specimen Banks ; *Crystallography, X-Ray ; Databases, Factual ; *Ethics, Professional ; Interprofessional Relations ; Mice ; *Mice, Knockout ; National Institutes of Health (U.S.) ; Publishing ; Research/*standards ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 134
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    Ethics panel coming together (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1995 Sep 29;269(5232):1807.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644753" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Advisory Committees ; *Bioethical Issues ; *Bioethics ; Federal Government ; Genetics ; Government ; Human Experimentation ; *Public Policy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 135
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    Potential animal model for AIDS (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1995 Sep 29;269(5232):1819, 1821.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569914" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acquired Immunodeficiency Syndrome/virology ; Animals ; *Disease Models, Animal ; HIV Reverse Transcriptase ; HIV-1/enzymology/*genetics ; Humans ; RNA-Directed DNA Polymerase/genetics ; Simian Immunodeficiency Virus/enzymology/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 136
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    Sunlight and melanoma: an answer from MTS1 (p16) (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maestro, R -- Boiocchi, M -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):15-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809600" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carrier Proteins/*genetics ; Cyclin-Dependent Kinase Inhibitor p16 ; *Genes, Tumor Suppressor ; Humans ; Melanoma/*etiology/genetics ; Mutation ; Neoplasms, Radiation-Induced/*genetics ; Protein Kinase Inhibitors ; Ultraviolet Rays/*adverse effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 137
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    New foot steps into walking debate (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oliwenstein, L -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):476-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624770" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Foot/*anatomy & histology ; *Fossils ; Hallux/anatomy & histology ; History, Ancient ; Hominidae/*anatomy & histology/physiology ; Humans ; *Locomotion ; South Africa
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 138
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    A new face for the glutamate receptor (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1995 Jan 13;267(5195):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7809622" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Membrane/*chemistry ; Cloning, Molecular ; Glycosylation ; Models, Molecular ; Phosphorylation ; Receptors, Glutamate/*chemistry/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 139
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    Risk assessment of low-level exposures (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-02-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, J D -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):604-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7839132" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; *Leukemia, Radiation-Induced/mortality ; *Neoplasms, Radiation-Induced/mortality ; Radiation Dosage ; Risk Assessment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 140
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    Functions of the proteasome: the lysis at the end of the tunnel (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, A L -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):522-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725095" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Archaeal Proteins ; Binding Sites ; Crystallography, X-Ray ; Cysteine Endopeptidases/chemistry/*metabolism ; Endopeptidases/chemistry/*metabolism ; Humans ; Hydrolysis ; Multienzyme Complexes/chemistry/*metabolism ; Proteasome Endopeptidase Complex ; Proteins/*metabolism ; Thermoplasma/enzymology ; Ubiquitins/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 141
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    Zinc and Alzheimer's disease (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maggio, J E -- Esler, W P -- Stimson, E R -- Jennings, J M -- Ghilardi, J R -- Mantyh, P W -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1920-1; author reply 1921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604269" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Humans ; Protein Binding ; Rats ; Solubility ; Zinc/*metabolism/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 142
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    Neurobiology. Brain center linked to perfect pitch (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-02-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowak, R -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):616.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7839136" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; *Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Male ; *Music ; *Pitch Discrimination ; Temporal Lobe/*anatomy & histology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 143
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    NAS management of RERF (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seligman, P J -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1749-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7741918" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Foundations/*organization & administration ; Government Agencies ; International Cooperation ; Japan ; National Academy of Sciences (U.S.) ; *Radiation Injuries ; United States ; Universities
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 144
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    Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-25
    Beschreibung: The high resolution three-dimensional x-ray structure of the metal sites of bovine heart cytochrome c oxidase is reported. Cytochrome c oxidase is the largest membrane protein yet crystallized and analyzed at atomic resolution. Electron density distribution of the oxidized bovine cytochrome c oxidase at 2.8 A resolution indicates a dinuclear copper center with an unexpected structure similar to a [2Fe-2S]-type iron-sulfur center. Previously predicted zinc and magnesium sites have been located, the former bound by a nuclear encoded subunit on the matrix side of the membrane, and the latter situated between heme a3 and CuA, at the interface of subunits I and II. The O2 binding site contains heme a3 iron and copper atoms (CuB) with an interatomic distance of 4.5 A; there is no detectable bridging ligand between iron and copper atoms in spite of a strong antiferromagnetic coupling between them. A hydrogen bond is present between a hydroxyl group of the hydroxyfarnesylethyl side chain of heme a3 and an OH of a tyrosine. The tyrosine phenol plane is immediately adjacent and perpendicular to an imidazole group bonded to CuB, suggesting a possible role in intramolecular electron transfer or conformational control, the latter of which could induce the redox-coupled proton pumping. A phenyl group located halfway between a pyrrole plane of the heme a3 and an imidazole plane liganded to the other heme (heme a) could also influence electron transfer or conformational control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsukihara, T -- Aoyama, H -- Yamashita, E -- Tomizaki, T -- Yamaguchi, H -- Shinzawa-Itoh, K -- Nakashima, R -- Yaono, R -- Yoshikawa, S -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1069-74.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Protein Research, Osaka University, Suita, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652554" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding Sites ; Cattle ; Copper/*analysis ; Crystallization ; Crystallography, X-Ray ; Electron Transport ; Electron Transport Complex IV/*chemistry/metabolism ; Fourier Analysis ; Heme/*analogs & derivatives/analysis ; Hydrogen Bonding ; Magnesium/*analysis ; Mitochondria, Heart/enzymology ; Models, Molecular ; Oxidation-Reduction ; Oxygen/metabolism ; Protein Conformation ; Protein Structure, Secondary ; Proton Pumps ; Zinc/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 145
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    New compounds make light of pests (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-05-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1995 May 12;268(5212):806.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754366" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Drosophila ; *Eosine I Bluish/toxicity ; Fluorescein ; *Fluoresceins/toxicity ; Humans ; *Insecticides/toxicity ; *Light ; Malathion/toxicity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 146
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    An active National Institute of Mental Health (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Varmus, H -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1681.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792582" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): National Institute of Mental Health (U.S.)/economics/*organization & ; administration ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 147
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    Asian hominids grow older (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, E -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1116-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502031" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Animals ; China ; Electron Spin Resonance Spectroscopy ; *Fossils ; History, Ancient ; *Hominidae/anatomy & histology ; Humans ; Magnetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 148
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    Serial analysis of gene expression (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-20
    Beschreibung: The characteristics of an organism are determined by the genes expressed within it. A method was developed, called serial analysis of gene expression (SAGE), that allows the quantitative and simultaneous analysis of a large number of transcripts. To demonstrate this strategy, short diagnostic sequence tags were isolated from pancreas, concatenated, and cloned. Manual sequencing of 1000 tags revealed a gene expression pattern characteristic of pancreatic function. New pancreatic transcripts corresponding to novel tags were identified. SAGE should provide a broadly applicable means for the quantitative cataloging and comparison of expressed genes in a variety of normal, developmental, and disease states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Velculescu, V E -- Zhang, L -- Vogelstein, B -- Kinzler, K W -- CA35494/CA/NCI NIH HHS/ -- CA57345/CA/NCI NIH HHS/ -- GM07309/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):484-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7570003" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Complementary/genetics ; *Gene Expression ; Gene Library ; *Genetic Techniques ; Humans ; Molecular Sequence Data ; Pancreas/*enzymology ; Polymerase Chain Reaction ; RNA, Messenger/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 149
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    Crystal structure of the mammalian Grb2 adaptor (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-14
    Beschreibung: The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2 and SH3 domains bring the two adjacent faces of the SH3 domains in van der Waals contact but leave room for the binding of proline-rich peptides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maignan, S -- Guilloteau, J P -- Fromage, N -- Arnoux, B -- Becquart, J -- Ducruix, A -- New York, N.Y. -- Science. 1995 Apr 14;268(5208):291-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Biologie Structurale, Unite Mixte de Recherche CNRS-Universite de Paris-Sud, Gif sur Yvette, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716522" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Binding Sites ; Computer Graphics ; Crystallization ; Crystallography, X-Ray ; GRB2 Adaptor Protein ; Hydrogen Bonding ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Structure, Secondary ; Proteins/*chemistry/metabolism ; *Receptor, Epidermal Growth Factor/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 150
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    Varmus puts his stamp on NIH (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481813" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administrative Personnel ; Budgets ; History, 20th Century ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 151
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    Tamoxifen's trials and tribulations (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):910.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481787" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anticarcinogenic Agents/adverse effects/*therapeutic use ; Breast Neoplasms/*prevention & control ; *Carcinogens ; *Clinical Trials as Topic ; Endometrial Neoplasms/chemically induced ; Female ; Heart Diseases/prevention & control ; Humans ; Osteoporosis/prevention & control ; Patient Selection ; Tamoxifen/*adverse effects/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 152
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    Architectures of class-defining and specific domains of glutamyl-tRNA synthetase (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-31
    Beschreibung: The crystal structure of a class I aminoacyl-transfer RNA synthetase, glutamyl-tRNA synthetase (GluRS) from Thermus thermophilus, was solved and refined at 2.5 A resolution. The amino-terminal half of GluRS shows a geometrical similarity with that of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) of the same subclass in class I, comprising the class I-specific Rossmann fold domain and the intervening subclass-specific alpha/beta domain. These domains were found to have two GluRS-specific, secondary-structure insertions, which then participated in the specific recognition of the D and acceptor stems of tRNA(Glu) as indicated by mutagenesis analyses based on the docking properties of GluRS and tRNA. In striking contrast to the beta-barrel structure of the GlnRS carboxyl-terminal half, the GluRS carboxyl-terminal half displayed an all-alpha-helix architecture, an alpha-helix cage, and mutagenesis analyses indicated that it had a role in the anticodon recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nureki, O -- Vassylyev, D G -- Katayanagi, K -- Shimizu, T -- Sekine, S -- Kigawa, T -- Miyazawa, T -- Yokoyama, S -- Morikawa, K -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):1958-65.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biophysics and Biochemistry, School of Science, University of Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701318" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Amino Acyl-tRNA Synthetases/chemistry ; Anticodon ; Biological Evolution ; Computer Graphics ; Crystallography, X-Ray ; Escherichia coli/enzymology ; Glutamate-tRNA Ligase/*chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA, Transfer, Glu/chemistry/metabolism ; Sequence Alignment ; Thermus thermophilus/*enzymology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 153
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    NIH funding. The price of compromise (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Sep 22;269(5231):1662.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569886" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome ; *Budgets ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 154
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    Transcriptional activation by tetracyclines in mammalian cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: A transcriptional transactivator was developed that fuses the VP16 activation domain with a mutant Tet repressor from Escherichia coli. This transactivator requires certain tetracycline (Tc) derivatives for specific DNA binding. Thus, addition of doxycycline to HeLa cells that constitutively synthesized the transactivator and that contained an appropriate, stably integrated reporter unit rapidly induced gene expression more than a thousandfold. The specificity of the Tet repressor-operator-effector interaction and the pharmacological characteristics of Tc's make this regulatory system well suited for the control of gene activities in vivo, such as in transgenic animals and possibly in gene therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gossen, M -- Freundlieb, S -- Bender, G -- Muller, G -- Hillen, W -- Bujard, H -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1766-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie der Universitat Heidelberg, (ZMDH), Im Neuenheimer Feld 282, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Doxycycline/*pharmacology ; Genes, Reporter ; HeLa Cells ; Humans ; Molecular Sequence Data ; Operator Regions, Genetic ; Recombinant Fusion Proteins/genetics ; Repressor Proteins/chemistry/*genetics ; Simplexvirus ; Trans-Activators/*genetics ; Transcriptional Activation/*drug effects ; Transfection ; Viral Proteins/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 155
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    Coactivator and promoter-selective properties of RNA polymerase I TAFs (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-12-01
    Beschreibung: Human ribosomal RNA synthesis by RNA polymerase I requires the activator UBF and the promoter selectivity factor SL1, which consists of the TATA binding protein (TBP) and three associated subunits, TAFI110, TAFI63, and TAFI48. Here it is shown that both TAFI110 and TAFI63 contact the promoter, whereas TAFI48 serves as a target for interaction with UBF and is required to form a transcriptionally active SL1 complex responsive to UBF in vitro. TAFI48 also alters the ability of TBP to interact with TATA box elements, and the resulting complex fails to support transcription by RNA polymerase II. Thus, TAFI48 may function both as a target to mediate UBF activation and as a class-specific promoter selectivity factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckmann, H -- Chen, J L -- O'Brien, T -- Tjian, R -- New York, N.Y. -- Science. 1995 Dec 1;270(5241):1506-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720-3204, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7491500" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): DNA-Binding Proteins/*metabolism ; HeLa Cells ; Humans ; *Pol1 Transcription Initiation Complex Proteins ; *Promoter Regions, Genetic ; RNA Polymerase I/*metabolism ; RNA Polymerase II/metabolism ; RNA, Ribosomal/biosynthesis/genetics ; Recombinant Proteins/metabolism ; TATA Box ; *TATA-Binding Protein Associated Factors ; TATA-Box Binding Protein ; *Transcription Factor TFIID ; Transcription Factors/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 156
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    CD1: presenting unusual antigens to unusual T lymphocytes (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bendelac, A -- New York, N.Y. -- Science. 1995 Jul 14;269(5221):185-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Princeton University, NJ 08544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7542402" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigen Presentation/*immunology ; Antigens, Bacterial/immunology ; Antigens, CD/genetics/*immunology ; Antigens, CD1 ; Biological Evolution ; Humans ; Immunophenotyping ; Lipids/*immunology ; Mice ; Peptides/*immunology ; T-Lymphocytes/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 157
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    Klausner follows own advice at NCI (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Aug 18;269(5226):912-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638609" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome ; Administrative Personnel ; History, 20th Century ; Humans ; National Institutes of Health (U.S.)/*organization & administration ; Neoplasms ; Research ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 158
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    NIH escapes the ax--for now (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618092" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Politics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 159
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    R&D budget takes shape in Congress, piece by piece. NIH: the view from the Senate (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):471.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Politics ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 160
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    Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-05-12
    Beschreibung: The borders of human visual areas V1, V2, VP, V3, and V4 were precisely and noninvasively determined. Functional magnetic resonance images were recorded during phase-encoded retinal stimulation. This volume data set was then sampled with a cortical surface reconstruction, making it possible to calculate the local visual field sign (mirror image versus non-mirror image representation). This method automatically and objectively outlines area borders because adjacent areas often have the opposite field sign. Cortical magnification factor curves for striate and extrastriate cortical areas were determined, which showed that human visual areas have a greater emphasis on the center-of-gaze than their counterparts in monkeys. Retinotopically organized visual areas in humans extend anteriorly to overlap several areas previously shown to be activated by written words.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sereno, M I -- Dale, A M -- Reppas, J B -- Kwong, K K -- Belliveau, J W -- Brady, T J -- Rosen, B R -- Tootell, R B -- EY07980/EY/NEI NIH HHS/ -- MH47035/MH/NIMH NIH HHS/ -- NICHD22614/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1995 May 12;268(5212):889-93.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Diego, La Jolla 92093-0515, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754376" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain Mapping/*methods ; Haplorhini ; Humans ; Magnetic Resonance Imaging/*methods ; Vision, Ocular ; Visual Cortex/anatomy & histology/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 161
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    Scientists named in PCR suit (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1273-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761847" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *DNA-Directed DNA Polymerase ; *Patents as Topic ; *Polymerase Chain Reaction ; Taq Polymerase ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 162
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    Women in clinical trials: an FDA perspective (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherman, L A -- Temple, R -- Merkatz, R B -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):793-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Drug Evaluation and Research, FDA, Rockville, MD 20857, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638593" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging ; *Clinical Trials as Topic ; Drug Approval ; Federal Government ; Female ; *Guidelines as Topic ; Humans ; Male ; Paternalism ; *Patient Selection ; Pregnant Women ; Research Design ; *Research Subjects ; Sex Characteristics ; United States ; *United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 163
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    Senate restores NIH funding cut (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1271-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761845" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 164
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    Functional isolation and characterization of human hematopoietic stem cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-06
    Beschreibung: Hematopoietic cells differentiate in steps marked by the acquisition or loss of specific phenotypic characteristics. Human bone marrow cells that were responsive to the early-acting cytokines Kit ligand and interleukin-3 were forced to a metabolic death. The subfraction remaining represented 1 in 10(5) bone marrow mononuclear cells, were determined to be quiescent by cell cycle analysis, and had a stem cell immunophenotype. The cells were highly enriched for long-term culture-initiating cells, were capable of secondary colony formation, and produced both myeloid and lymphoid progeny. Thus, this technically simple strategy led to the efficient purification of cells with characteristics of hematopoietic stem cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berardi, A C -- Wang, A -- Levine, J D -- Lopez, P -- Scadden, D T -- R01-HL44851/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):104-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology/Oncology, Deaconess Hospital, Harvard Medical School, Boston, MA 02215.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7528940" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, CD/analysis ; Antigens, CD34 ; Base Sequence ; Cell Differentiation ; Cell Division ; Cell Separation/*methods ; Cells, Cultured ; Colony-Forming Units Assay ; DNA, Complementary/genetics ; Flow Cytometry ; Fluorouracil/pharmacology ; Hematopoietic Cell Growth Factors/pharmacology ; Hematopoietic Stem Cells/*cytology/drug effects ; Humans ; Immunophenotyping ; Interleukin-3/pharmacology ; Molecular Sequence Data ; Proto-Oncogene Proteins/analysis ; Proto-Oncogene Proteins c-kit ; Receptor Protein-Tyrosine Kinases/analysis ; Receptors, Colony-Stimulating Factor/analysis ; Stem Cell Factor
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 165
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    Human genome project. Emphasis turns from mapping to large-scale sequencing (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1270-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761844" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Chromosome Mapping/economics ; Financing, Government ; *Genome, Human ; Government Agencies/economics ; *Human Genome Project/economics ; Humans ; National Institutes of Health (U.S.)/economics ; Research Support as Topic ; *Sequence Analysis, DNA/economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 166
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    Functional brain imaging studies of cortical mechanisms for memory (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-03
    Beschreibung: Recent functional brain imaging studies in humans indicate that learning and memory involve many of the same regions of the cortex that process sensory information and control motor output. The forms of perceptual and motor learning that can occur without conscious recollection are mediated in part by contractions and expansions of representations in the sensory and motor cortex. The same regions are also engaged during the conscious storage and retrieval of facts and events, but these types of memory also bring into play structures involved in the active maintenance of memories "on line" and in the establishment of associative links between the information stored in different sensory areas. Although the picture of memory that is emerging from functional imaging studies is consistent with current physiological accounts, there are puzzles and surprises that will be solved only through a combination of human and animal studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ungerleider, L G -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):769-75.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Psychology and Psychopathology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481764" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain Mapping ; Cerebral Cortex/anatomy & histology/*physiology/radiography ; Haplorhini ; Humans ; Learning ; Magnetic Resonance Imaging ; Memory/*physiology ; Motor Cortex/physiology ; Motor Skills ; Parietal Lobe/physiology ; Prefrontal Cortex/anatomy & histology/*physiology/radionuclide imaging ; Psychomotor Performance ; Temporal Lobe/physiology ; Tomography, Emission-Computed ; Visual Cortex/anatomy & histology/*physiology/radionuclide imaging ; Visual Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 167
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    Researchers find molecules that muzzle killer cells (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):367-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716537" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antigens, Ly ; Histocompatibility Antigens Class I/metabolism ; Humans ; Killer Cells, Natural/*immunology ; Lectins, C-Type ; Membrane Glycoproteins/metabolism ; Mice ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Immunologic/*metabolism ; Receptors, NK Cell Lectin-Like ; T-Lymphocytes, Cytotoxic/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 168
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    AIDS research policy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cox, S -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1406.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878452" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acquired Immunodeficiency Syndrome ; Humans ; *Research
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 169
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    Women's health research blossoms (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, C -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):766-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biomedical Research ; Clinical Trials as Topic ; Cultural Characteristics ; Developing Countries ; Female ; Humans ; *Internationality ; Male ; Maternal Health Services ; *Patient Selection ; Poverty ; *Research ; Research Design ; *Research Subjects ; Resource Allocation ; Sex Characteristics ; *Women's Health
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 170
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    Designer tissues take hold (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1995 Oct 13;270(5234):230-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569968" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; *Artificial Organs ; *Biocompatible Materials ; *Biomedical Engineering ; Cartilage, Articular/cytology/transplantation ; Cell Transplantation ; Culture Techniques ; Endothelium, Vascular/cytology ; Humans ; Liver/cytology ; Molecular Sequence Data ; Neurons/cytology ; *Organoids ; Skin, Artificial ; Tissue Transplantation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 171
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    Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-20
    Beschreibung: Adenosine deaminase (ADA) deficiency results in severe combined immunodeficiency, the first genetic disorder treated by gene therapy. Two different retroviral vectors were used to transfer ex vivo the human ADA minigene into bone marrow cells and peripheral blood lymphocytes from two patients undergoing exogenous enzyme replacement therapy. After 2 years of treatment, long-term survival of T and B lymphocytes, marrow cells, and granulocytes expressing the transferred ADA gene was demonstrated and resulted in normalization of the immune repertoire and restoration of cellular and humoral immunity. After discontinuation of treatment, T lymphocytes, derived from transduced peripheral blood lymphocytes, were progressively replaced by marrow-derived T cells in both patients. These results indicate successful gene transfer into long-lasting progenitor cells, producing a functional multilineage progeny.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bordignon, C -- Notarangelo, L D -- Nobili, N -- Ferrari, G -- Casorati, G -- Panina, P -- Mazzolari, E -- Maggioni, D -- Rossi, C -- Servida, P -- Ugazio, A G -- Mavilio, F -- B.36/Telethon/Italy -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):470-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Telethon Gene Therapy Program for Genetic Diseases, DIBIT, Istituto Scientifico H. S. Raffaele, Milan, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7570000" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Deaminase/administration & ; dosage/blood/*deficiency/*genetics/therapeutic use ; Antibody Formation ; Base Sequence ; Bone Marrow Cells ; Cells, Cultured ; Child, Preschool ; *Gene Transfer Techniques ; *Genetic Therapy ; Genetic Vectors ; Hematopoietic Stem Cell Transplantation ; *Hematopoietic Stem Cells/enzymology ; Humans ; Immunity, Cellular ; Lymphocyte Transfusion ; *Lymphocytes/enzymology/immunology ; Molecular Sequence Data ; Severe Combined Immunodeficiency/enzymology/genetics/immunology/*therapy ; T-Lymphocytes/enzymology/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 172
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    Russian chaos breeds diphtheria outbreak (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maurice, J -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7878458" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Child ; Communicable Disease Control ; Diphtheria/*epidemiology/immunology/prevention & control ; Diphtheria Toxoid ; *Disease Outbreaks/prevention & control ; Humans ; Immunization Programs ; Russia/epidemiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 173
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    A new guide to the human genome (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-12-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1995 Dec 22;270(5244):1919-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8533080" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Computer Communication Networks ; Genetic Markers ; *Genome, Human ; *Human Genome Project ; Humans ; Polymerase Chain Reaction ; *Sequence Analysis, DNA ; *Sequence Tagged Sites
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 174
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    Weight-reducing effects of the plasma protein encoded by the obese gene (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-28
    Beschreibung: The gene product of the ob locus is important in the regulation of body weight. The ob product was shown to be present as a 16-kilodalton protein in mouse and human plasma but was undetectable in plasma from C57BL/6J ob/ob mice. Plasma levels of this protein were increased in diabetic (db) mice, a mutant thought to be resistant to the effects of ob. Daily intraperitoneal injections of either mouse or human recombinant OB protein reduced the body weight of ob/ob mice by 30 percent after 2 weeks of treatment with no apparent toxicity but had no effect on db/db mice. The protein reduced food intake and increased energy expenditure in ob/ob mice. Injections of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halaas, J L -- Gajiwala, K S -- Maffei, M -- Cohen, S L -- Chait, B T -- Rabinowitz, D -- Lallone, R L -- Burley, S K -- Friedman, J M -- DK41096/DK/NIDDK NIH HHS/ -- RR00862/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):543-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624777" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipose Tissue/drug effects ; Animals ; Blood Glucose/analysis ; Body Composition/drug effects ; Diabetes Mellitus/blood/physiopathology ; Eating/drug effects ; Energy Metabolism/drug effects ; Female ; Humans ; Leptin ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/blood/genetics/*physiopathology ; Proteins/analysis/genetics/*pharmacology/physiology ; Recombinant Proteins/administration & dosage/pharmacology ; Weight Loss/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 175
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    KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2 (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-05-12
    Beschreibung: A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, J T -- Lamb, P W -- Rinker-Schaeffer, C W -- Vukanovic, J -- Ichikawa, T -- Isaacs, J T -- Barrett, J C -- CA 58236/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 May 12;268(5212):884-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754374" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antigens, CD/chemistry/*genetics/physiology ; Antigens, CD82 ; Base Sequence ; Biological Evolution ; *Chromosomes, Human, Pair 11 ; Gene Expression ; *Genes, Tumor Suppressor ; Humans ; Male ; Membrane Glycoproteins/chemistry/*genetics/physiology ; Mice ; Mice, SCID ; Molecular Sequence Data ; Neoplasm Metastasis/*genetics ; Prostatic Neoplasms/*genetics/pathology ; *Proto-Oncogene Proteins ; Rats ; Transfection ; Tumor Cells, Cultured
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 176
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    How the glucocorticoids suppress immunity (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1995 Oct 13;270(5234):232-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569969" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Nucleus/metabolism ; DNA/metabolism ; DNA-Binding Proteins/biosynthesis/genetics/*metabolism ; Dexamethasone/pharmacology ; Glucocorticoids/*pharmacology ; Humans ; *I-kappa B Proteins ; *Immunosuppression ; Immunosuppressive Agents/*pharmacology ; NF-kappa B/*antagonists & inhibitors/metabolism ; Receptors, Glucocorticoid/metabolism ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 177
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCutchen, C W -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1032-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652542" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Authorship ; *Plagiarism ; United States ; *United States Office of Research Integrity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 178
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    Plio-Pleistocene African climate (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-06
    Beschreibung: Marine records of African climate variability document a shift toward more arid conditions after 2.8 million years ago (Ma), evidently resulting from remote forcing by cold North Atlantic sea-surface temperatures associated with the onset of Northern Hemisphere glacial cycles. African climate before 2.8 Ma was regulated by low-latitude insolation forcing of monsoonal climate due to Earth orbital precession. Major steps in the evolution of African hominids and other vertebrates are coincident with shifts to more arid, open conditions near 2.8 Ma, 1.7 Ma, and 1.0 Ma, suggesting that some Pliocene (Plio)-Pleistocene speciation events may have been climatically mediated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉deMenocal, P B -- New York, N.Y. -- Science. 1995 Oct 6;270(5233):53-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lamont-Doherty Earth Observatory, Palisades, NY 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569951" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Animals ; *Biological Evolution ; *Climate ; *Fossils ; *Geologic Sediments ; *Hominidae ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 179
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    Identification of a graft versus host disease-associated human minor histocompatibility antigen (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-09
    Beschreibung: Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉den Haan, J M -- Sherman, N E -- Blokland, E -- Huczko, E -- Koning, F -- Drijfhout, J W -- Skipper, J -- Shabanowitz, J -- Hunt, D F -- Engelhard, V H -- AI20963/AI/NIAID NIH HHS/ -- AI33993/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 9;268(5216):1476-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunohaematology, University Hospital, Leiden, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7539551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Bone Marrow Transplantation ; Epitopes ; Female ; Graft vs Host Disease/*immunology ; HLA-A2 Antigen/immunology ; Humans ; Mass Spectrometry ; Minor Histocompatibility Antigens/chemistry/*immunology ; Molecular Sequence Data ; Neoplasm Proteins/chemistry/*immunology ; Oligopeptides/chemistry/immunology ; T-Lymphocytes, Cytotoxic/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 180
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    Oncogenes and cancer (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duesberg, P H -- New York, N.Y. -- Science. 1995 Mar 10;267(5203):1407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7794335" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3T3 Cells ; Animals ; Cell Transformation, Neoplastic/*genetics ; *Genes, ras ; Humans ; Mice ; Neoplasms/*genetics ; *Oncogenes ; Point Mutation ; Promoter Regions, Genetic ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 181
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    Finis to MicroGeneSys saga? (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1995 Jan 20;267(5196):335.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824931" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines ; *Acquired Immunodeficiency Syndrome ; Financing, Government ; Government Agencies ; Humans ; Peer Review, Research ; Recombinant Proteins ; *Research Support as Topic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 182
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    Helping neurons find their way (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-05-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1995 May 19;268(5213):971-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754391" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/*physiology ; Chemotactic Factors/*physiology ; Glycoproteins/physiology ; Humans ; Nerve Growth Factors/*physiology ; Semaphorin-3A ; Tumor Suppressor Proteins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 183
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    Patterns of human growth (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heinrichs, C -- Munson, P J -- Counts, D R -- Cutler, G B Jr -- Baron, J -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):442-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716552" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Height ; Body Weight ; Cephalometry ; Female ; *Growth ; Humans ; Infant ; Kinetics ; Male ; Regression Analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 184
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    A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-01
    Beschreibung: A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human melanoma. The mutated CDK4 allele was present in autologous cultured melanoma cells and metastasis tissue, but not in the patient's lymphocytes. The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide recognized by CTLs and prevented binding of the CDK4 inhibitor p16INK4a, but not of p21 or of p27KIP1. The same mutation was found in one additional melanoma among 28 melanomas analyzed. These results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfel, T -- Hauer, M -- Schneider, J -- Serrano, M -- Wolfel, C -- Klehmann-Hieb, E -- De Plaen, E -- Hankeln, T -- Meyer zum Buschenfelde, K H -- Beach, D -- New York, N.Y. -- Science. 1995 Sep 1;269(5228):1281-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universitat, Mainz, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652577" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Carrier Proteins/metabolism/*pharmacology ; *Cell Cycle Proteins ; Cell Line ; Cloning, Molecular ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p16 ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p27 ; *Cyclin-Dependent Kinases ; Cyclins/metabolism/pharmacology ; HLA-A2 Antigen/immunology ; Humans ; Melanoma/enzymology/*immunology ; Microtubule-Associated Proteins/metabolism/pharmacology ; Molecular Sequence Data ; Point Mutation ; Polymerase Chain Reaction ; Protein-Serine-Threonine Kinases/antagonists & ; inhibitors/genetics/*immunology/metabolism ; *Proto-Oncogene Proteins ; T-Lymphocytes, Cytotoxic/*immunology ; Transfection ; Tumor Cells, Cultured ; *Tumor Suppressor Proteins
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 185
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    Inactivation of the mouse Huntington's disease gene homolog Hdh (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-21
    Beschreibung: Huntington's disease (HD) is a dominant neurodegenerative disorder caused by expansion of a CAG repeat in the gene encoding huntingtin, a protein of unknown function. To distinguish between "loss of function" and "gain of function" models of HD, the murine HD homolog Hdh was inactivated by gene targeting. Mice heterozygous for Hdh inactivation were phenotypically normal, whereas homozygosity resulted in embryonic death. Homozygotes displayed abnormal gastrulation at embryonic day 7.5 and were resorbing by day 8.5. Thus, huntingtin is critical early in embryonic development, before the emergence of the nervous system. That Hdh inactivation does not mimic adult HD neuropathology suggests that the human disease involves a gain of function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duyao, M P -- Auerbach, A B -- Ryan, A -- Persichetti, F -- Barnes, G T -- McNeil, S M -- Ge, P -- Vonsattel, J P -- Gusella, J F -- Joyner, A L -- NS16367/NS/NINDS NIH HHS/ -- NS32765/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):407-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618107" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Line ; Ectoderm/cytology ; Embryonic and Fetal Development ; Female ; Gene Targeting ; Genotype ; Heterozygote ; Homozygote ; Humans ; Huntington Disease/*genetics ; Male ; Mesoderm/cytology ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Nerve Tissue Proteins/*genetics/physiology ; Nuclear Proteins/*genetics/physiology ; Phenotype ; Stem Cells/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 186
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    The T cell receptor begins to reveal its many facets (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):459-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824945" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens/immunology ; Autoimmune Diseases/immunology ; Graft Rejection ; Humans ; Ligands ; Lymphocyte Activation ; Membrane Proteins/metabolism ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, T-Cell/chemistry/*immunology/metabolism ; Signal Transduction ; T-Lymphocytes/*immunology ; ZAP-70 Protein-Tyrosine Kinase
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 187
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    Women's Health Research (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1995 Aug 11;269(5225):765-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7638585" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; Humans ; Research ; *Women's Health
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 188
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    Navigating the folding routes (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolynes, P G -- Onuchic, J N -- Thirumalai, D -- New York, N.Y. -- Science. 1995 Mar 17;267(5204):1619-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Chemical Sciences, University of Illinois, Urbana 61801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7886447" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Computer Simulation ; Models, Chemical ; Models, Molecular ; Protein Conformation ; *Protein Folding ; Protein Structure, Secondary ; Temperature ; Thermodynamics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 189
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    Depicting epidemiology (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-12-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, A H -- New York, N.Y. -- Science. 1995 Dec 15;270(5243):1743-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8525357" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Epidemiology ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 190
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    Detecting Alzheimer's disease (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- Kumar, S R -- Thach, A B -- Kiat-Winarko, T -- Frambach, D A -- New York, N.Y. -- Science. 1995 Mar 17;267(5204):1577; author reply 1580-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7741897" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Alzheimer Disease/*diagnosis ; Female ; Humans ; Male ; Pupil/*drug effects ; *Tropicamide
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 191
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    "The Duesberg phenomenon": Duesberg and other voices (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plotkin, S A -- New York, N.Y. -- Science. 1995 Jan 20;267(5196):315-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7880305" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*virology ; Animals ; HIV Infections/congenital ; Haplorhini ; Humans ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 192
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    The Devi case and more (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-08-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devi, S J -- New York, N.Y. -- Science. 1995 Aug 25;269(5227):1030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7652537" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Authorship ; Cryptococcus neoformans/immunology ; Fungal Vaccines ; National Institutes of Health (U.S.) ; *Publishing ; United States ; United States Office of Research Integrity ; Vaccines, Conjugate
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 193
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    Permeation selectivity by competition in a delayed rectifier potassium channel (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-21
    Beschreibung: Permeation selectivity was studied in two human potassium channels, Kv2.1 and Kv1.5, expressed in a mouse cell line. With normal concentrations of potassium and sodium, both channels were highly selective for potassium. On removal of potassium, Kv2.1 displayed a large sodium conductance that was inhibited by low concentrations of potassium. The channel showed a competition mechanism of selectivity similar to that of calcium channels. In contrast, Kv1.5 displayed a negligible sodium conductance on removal of potassium. The observation that structurally similar potassium channels show different abilities to conduct sodium provides a basis for understanding the structural determinants of potassium channel selectivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korn, S J -- Ikeda, S R -- New York, N.Y. -- Science. 1995 Jul 21;269(5222):410-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618108" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding, Competitive ; Delayed Rectifier Potassium Channels ; Humans ; L Cells (Cell Line) ; Membrane Potentials ; Mice ; Potassium/*metabolism ; Potassium Channels/*metabolism ; *Potassium Channels, Voltage-Gated ; Shab Potassium Channels ; Sodium/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 194
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    Attenuated retrovirus vaccines and AIDS (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, P A -- New York, N.Y. -- Science. 1995 Nov 17;270(5239):1219-20; author reply 1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *AIDS Vaccines ; Animals ; Animals, Newborn ; Female ; HIV Infections/*prevention & control/transmission ; Humans ; Macaca mulatta ; Male ; Simian Immunodeficiency Virus/pathogenicity ; Vaccination ; Vaccines, Attenuated
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 195
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    Thumbs, tools, and early humans (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamrick, M W -- Inouye, S E -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):586-7; author reply 589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725112" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Biomechanical Phenomena ; Fossils ; Gorilla gorilla/*anatomy & histology ; History, Ancient ; Hominidae/*anatomy & histology ; Humans ; Motor Skills ; Pan troglodytes/anatomy & histology ; Thumb/*anatomy & histology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 196
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    Dioxins in Vietnam (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westing, A H -- Pfeiffer, E W -- New York, N.Y. -- Science. 1995 Oct 13;270(5234):217.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569959" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Environmental Pollution ; *Hazardous Substances ; *Tetrachlorodibenzodioxin ; United States ; Vietnam
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 197
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    Play ball! (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-06-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, H N -- New York, N.Y. -- Science. 1995 Jun 23;268(5218):1681; author reply 1683-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7792583" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Baseball ; Humans ; *Motion Perception ; *Psychomotor Performance ; *Space Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 198
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    The centromere: hub of chromosomal activities (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-12-08
    Beschreibung: Centromeres are the structures that direct eukaryotic chromosome segregation in mitosis and meiosis. There are two major classes of centromeres. Point centromeres, found in the budding yeasts, are compact loci whose constituent proteins are now beginning to yield to biochemical analysis. Regional centromeres, best described in the fission yeast Schizosaccharomyces pombe, encompass many kilobases of DNA and are packaged into heterochromatin. Their associated proteins are as yet poorly understood. In addition to providing the site for microtubule attachment, centromeres also have an important role in checkpoint regulation during mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pluta, A F -- Mackay, A M -- Ainsztein, A M -- Goldberg, I G -- Earnshaw, W C -- GM35212/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Dec 8;270(5242):1591-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology and Anatomy, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7502067" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anaphase ; Animals ; Centromere/chemistry/*physiology ; Chromosomes/*physiology ; DNA/metabolism ; Heterochromatin/chemistry/physiology ; Humans ; Interphase ; Kinetochores/chemistry/physiology ; Microtubules/metabolism ; *Mitosis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 199
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    Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-10
    Beschreibung: Polychlorinated biphenyls (PCBs) typify a class of stable aromatic pollutants that are targeted by bioremediation strategies. In the aerobic degradation of biphenyl by bacteria, the key step of ring cleavage is catalyzed by an Fe(II)-dependent extradiol dioxygenase. The crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase from a PCB-degrading strain of Pseudomonas cepacia has been determined at 1.9 angstrom resolution. The monomer comprises amino- and carboxyl-terminal domains. Structural homology between and within the domains reveals evolutionary relationships within the extradiol dioxygenase family. The iron atom has five ligands in square pyramidal geometry: one glutamate and two histidine side chains, and two water molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Han, S -- Eltis, L D -- Timmis, K N -- Muchmore, S W -- Bolin, J T -- GM 52831/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):976-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481800" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Binding Sites ; Biodegradation, Environmental ; Crystallography, X-Ray ; *Dioxygenases ; Evolution, Molecular ; Ferrous Compounds/chemistry/metabolism ; Hydrogen Bonding ; Ligands ; Models, Molecular ; Molecular Sequence Data ; Oxygen/chemistry/metabolism ; Oxygenases/*chemistry/metabolism ; Polychlorinated Biphenyls/metabolism ; *Protein Conformation ; Protein Structure, Secondary ; Pseudomonas/*enzymology ; Sequence Alignment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 200
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    Science in the stationary phase (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-09-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kornberg, A -- New York, N.Y. -- Science. 1995 Sep 29;269(5232):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569906" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Financing, Government ; National Institutes of Health (U.S.) ; *Research ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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