Publication Date:
1991-12-13
Description:
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Bruggen, P -- Traversari, C -- Chomez, P -- Lurquin, C -- De Plaen, E -- Van den Eynde, B -- Knuth, A -- Boon, T -- New York, N.Y. -- Science. 1991 Dec 13;254(5038):1643-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research, Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1840703" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, Neoplasm/*genetics
;
Base Sequence
;
Blotting, Northern
;
Cloning, Molecular
;
DNA/genetics
;
Gene Expression
;
Genes, Neoplasm
;
Humans
;
Melanoma/*immunology
;
Melanoma-Specific Antigens
;
Molecular Sequence Data
;
*Neoplasm Proteins
;
Polymerase Chain Reaction
;
RNA, Messenger/genetics
;
RNA, Neoplasm/genetics
;
T-Lymphocytes, Cytotoxic/*immunology
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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