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  • Articles  (70)
  • hypertension  (28)
  • Drosophila
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  • Springer  (70)
  • 2005-2009
  • 1980-1984  (70)
  • 1965-1969
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  • 1984  (70)
  • 1
    Electronic Resource
    Electronic Resource
    Adjacent chromosomal regions can evolve at very different rates: Evolution of theDrosophila 68C glue gene cluster (1984)
    Springer
    Journal of molecular evolution 20 (1984), S. 251-264 
    Details
    ISSN: 1432-1432
    Keywords: Drosophila ; Genome evolution ; 68C Glue gene cluster ; Drosophila melanogaster species subgroup
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The 68C puff is a highly transcribed region of theDrosophila melanogaster salivary gland polytene chromosomes. Three different classes of messenger RNA originate in a 5000-bp region in the puff; each class is translated to one of the salivary gland glue proteins sgs-3, sgs-7, or sgs-8. These messenger RNA classes are coordinately controlled, with each RNA appearing in the third larval instar and disappearing at the time of puparium formation. Their disappearance is initiated by the action of the steroid hormone ecdysterone. In the work reported here, we studied evolution of this hormone-regulated gene cluster in themelanogaster species subgroup ofDrosophila. Genome blot hybridization experiments showed that five other species of this subgroup have DNA sequences that hybridize toD. melanogaster 68C sequences, and that these sequences are divided into a highly conserved region, which does not contain the glue genes, and an extraordinarily diverged region, which does. Molecular cloning of this DNA fromD. simulans, D. erecta, D. yakuba, andD. teissieri confirmed the division of the region into a slowly and a rapidly evolving protion, and also showed that the rapidly evolving region of each species codes for third instar larval salivary gland RNAs homologous to theD. melanogaster glue mRNAs. The highly conserved region is at least 13,000 bp long, and is not known to code for any RNAs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02104731
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  • 2
    Electronic Resource
    Electronic Resource
    Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster (1984)
    Springer
    Development genes and evolution 193 (1984), S. 267-282 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Larval cuticle ; Pattern formation ; Embryonic lethal mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In a search for embryonic lethal mutants on the second chromosome ofDrosophila melanogaster, 5764 balanced lines isogenic for an ethyl methane sulfonate (EMS)-treatedcn bw sp chromosome were established. Of these lines, 4217 carried one or more newly induced lethal mutations corresponding to a total of 7600 lethal hits. Eggs were collected from lethal-bearing lines and unhatched embryos from the lines in which 25% or more of the embryos did not hatch (2843 lines) were dechorionated, fixed, cleared and scored under the compound microscope for abnormalities of the larval cuticle. A total of 272 mutants were isolated with phenotypes unequivocally distinguishable from wild-type embryos on the basis of the cuticular pattern. In complementation tests performed between mutants with similar phenotype, 48 loci were identified by more than one allele, the average being 5.4 alleles per locus. Complementation of all other mutants was shown by 13 mutants. Members of the complementation groups were mapped by recombination analysis. No clustering of loci with similar phenotypes was apparent. From the distribution of the allele frequencies and the rate of discovery of new loci, it was estimated that the 61 loci represent the majority of embryonic lethal loci on the second chromosome yielding phenotypes recognizable in the larval cuticle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848156
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  • 3
    Electronic Resource
    Electronic Resource
    Isolation and characterization of temperature-sensitivelethal (2) giant larva alleles (1984)
    Springer
    Development genes and evolution 193 (1984), S. 90-97 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Temperature-sensitive ; Neoplasms ; Differentiation ; Imaginal discs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary EMS induced temperature-sensitivelethal (2) giant larva, 1(2)gl, alleles were isolated by screening against a knownl(2)gl allele. Analysis of the lethal phase of thel(2)gl ts-deficiency heterozygotes demonstrated: (1) the majority of thel(2)gl tslarvae survive to late third instar, (2) at 29°C the majority of thel(2)gl tslarvae failed to pupate and only rarely did they differentiate adult cuticular structures, (3) at 15°C the majority of the larvae pupated and frequently differentiated adult cuticular structures. Examination of the imaginal discs ofl(2)gl tslarvae reared at 29°C revealed the presence of morphologically abnormal wing, haltere and leg imaginal discs. No morphologically abnormal discs were found in thel(2)gl tslarvae reared at 15°C. Studies on both the histology and the developmental capacity of the morphologically normal and abnormall(2)gl tsdiscs were performed. The morphologically normal discs are histologically normal and produce a full complement of adult cuticular structures. However, the morphologically abnormal discs contained both regions that maintained the normal monolayer epithelium and regions that had lost the normal tissue architecture. The implants obtained when the morphologically abnormal discs are injected into metamorphosing larvae contained only a limited number of the normal complement of adult structures and usually only structures found in the ventral wing hinge region were recovered. In addition, the “metamorphosed” morphologically abnormal discs contained undifferentiated tissue that gave rise to transplantable neoplasms when cultured in adults. The results of the studies on the pathology of thel(2)gl tslarvae are discussed with respect to the role of thel(2)gl tsfunction during normal development, the autonomy of the neoplastic development of thel(2)gl tstissues, and similarities between neoplastic development inDrosophila and mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848636
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  • 4
    Electronic Resource
    Electronic Resource
    Heterospecific combinations of germ cells and gonadal soma betweenDrosophila melanogaster, D. mauritiana andD. ananassae (1984)
    Springer
    Development genes and evolution 194 (1984), S. 99-106 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Pole cell transplantation ; Heterospecific combinations ; Gametogenesis ; Chorion morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We transplanted pole cells betweenDrosophila melanogaster, D. mauritiana andD. ananassae to investigate the ability of germ cells to develop in the gonad of a heterospecific host, and to study the interaction between somatic follicle cells and the cells of the germ line in producing the species-specific chorion. FemaleD. mauritiana germ cells in aD. melanogaster ovary produced functional eggs with normal development potential. The same is true for the reciprocal combination. FemaleD. ananassae pole cells in aD. melanogaster host only developed to a very early stage and degenerated afterwards. None of the interspecific combinations of male pole cells led to functional sperm. We could not determine at what stage the transplanted male pole cells were arrested. The cooperation of follicle cells and the oocyte-nurse cell complex in producing the chorion was studied using the germ-line-dependent mutationfs(1) K10 ofD. melanogaster, which causes fused respiratory appendages and an abnormal chorion morphology. Wild-type femaleD. mauritiana germ cells in a mutantfs(1) K10 D. melanogaster ovary led to the production of wild-type eggs withD. melanogaster-specific, short respiratory appendages. On the other hand,D. melanogaster fs(1) K10 germ cells in aD. mauritiana ovary induced the formation of eggs with mutant fused appendages which were, however, typicallyD. mauritiana in length. When.D. mauritiana pole cells developed in aD. melanogaster ovary, the chorion exhibited a new imprint pattern that differs from both species-specific patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848349
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  • 5
    Electronic Resource
    Electronic Resource
    Isolation and characterization of temperature-sensitivelethal(2)giant larva alleles (1984)
    Springer
    Development genes and evolution 193 (1984), S. 98-107 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Neoplasms ; Promotion ; Regeneration ; Temperature-sensitive ; Imaginal discs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In this paper we present an analysis of the behavior ofl(2)gl tsimaginal wing discs during culture in adult hosts. Thel(2)gl tslarvae reared at 29° C contain two types of wing discs, those that are morphologically normal and those that are abnormal. When discs of both types are cultured in adult hosts at 29° C, the restrictive temperature, they give rise to transplantable neoplastic tissue. However, when the 29° C reared discs are cultured at 15° C, the permissive temperature, the morphologically normal discs maintain their morphology, but the morphologically abnormal discs give rise to neoplasms. Thel(2)gl tslarvae reared at 15° C contain only morphologically normal discs. When these discs are cultured in adult hosts at 29° C they give rise to neoplasms, however if the discs are cultured at 15° C they maintain their normal morphology. These results demonstrate: (1) that all wing imaginal discs obtained from 29° C rearedl(2)gl tslarvae are competent to undergo neoplastic development, (2) the morphologically abnormal discs obtained from the 29° C rearedl(2)gl tslarvae are committed to neoplastic development, (3) the neoplastic development of the morphologically normal discs is temperature dependent, (4) once the neoplastic development of thel(2)gl tsdiscs has been initiated the process is not readily reversible. In addition, the ability ofl(2)gl tswing discs to perform epimorphic regulation was tested by amputating morphologically normal permissively rearedl(2)gl tswing discs and culturing both fragiments at the permissive temperature. Fragments of control wild-type discs maintained their morphology during culture at the permissive temperature. However, both fragments of txel(2)gl tsdiscs became neoplastic. This result is discussed with respect to a possible role for thel(2)gl +function in epimorphic regulation and with respect to the phenomena of tumor promotion in vertebrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848637
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  • 6
    Electronic Resource
    Electronic Resource
    Changes in the distribution of gap junctions inDrosophila melanogaster wing discs during the third larval and early pupal stages of development (1984)
    Springer
    Development genes and evolution 193 (1984), S. 187-196 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Gap junction ; Imaginal disc ; Pattern formation ; EM Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Developmental changes in the distribution of gap junctions in early, mid and late third larval stage wing discs and in pupariation+6 h and pupariation+24 h stage wing discs fromDrosophila melanogaster were analyzed by quantitative electron microscopy. Gap junctions occur in all 12 intradisc regions examined in each of the five developmental stages. Their distribution is non-random and changes during development which suggests that they are developmentally regulated. The gap junctions are not static structures, rather they grow and regress during development. The changes tend to be gradual ones without sudden increases or decreases. Gap junctions continuously form and grow in size throughout the third larval stage and during the first 6 h following pupariation. Their surface density, number, percent of the lateral plasma membrane area, and absolute area as well as the lateral plasma membrane surface density all increase during this time. Between pupariation+ 6 h and pupariation+24 h all but one of these parameters decrease indicative of gap junctional breakdown. Gap junctions are most numerous and change least during development in the apical cell regions where intercellular contacts are close and stable. They change most in the basal cell regions where intercellular contacts tend to be looser and change during development. The most dramatic change is in the absolute area which increases by a factor of 23 between the early third larval stage and pupariation+24 h. At pupariation the rate of gap junction growth undergoes a transient increase before the phase of disassembly begins. Developmental changes in gap junction surface density are closely coupled with changes in the lateral plasma membrane surface density which suggests that these may be coregulated. Evidence from mutants suggests that when the number and density of gap junctions fail to increase in proportion to lateral plasma membrane growth, wing disc development will be abnormal. Our results support the idea that some minimum gap junction density is required for normal development and that this must increase as development proceeds. The results are consistent with the notion that gap junctions are involved in pattern formation and growth control and are discussed with respect to the acquisition of competence for metamorphosis, disc growth, disc morphogenesis and changes in the hormonal environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01260338
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  • 7
    Electronic Resource
    Electronic Resource
    Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster (1984)
    Springer
    Development genes and evolution 193 (1984), S. 296-307 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Larval cuticle ; Pattern formation ; Embryonic lethal mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In order to identify X-chromosomal genes required inDrosophila for early patterning and morphogenesis, we examined embryos hemizygous for EMS-induced lethal mutations to determine which of those mutations cause gross morphological defects. Embryos from 2711 lethal lines, corresponding to 3255 lethal point mutations were studied. Only 21% caused death during embryogenesis and of these, only one-sixth, or 3% of the total lethals, were associated with defects visible in the final cuticle pattern. Of the 114 point mutants causing visible cuticle defects, 76 could be assigned to 14 complementation groups. An additional 25 mutations mapping to regions of the X-chromosome not covered by male fertile duplications were assigned to six complementation groups based on similarities of map position and phenotype. Thirteen mutations could not be assigned to complementation groups. All mutations allowed normal development through the cellular blastoderm stage, the first defects associated with the earliest acting loci being observed shortly after the onset of gastrulation. The phenotypes of the various loci range from alterations in segment pattern or early morphogenetic movements to defects in final pigmentation and denticle morphology. Cuticle preparations were also examined for 63 deletions spanning in total 74% of the X-chromosome, as well as for 8 deletions and point mutations derived in saturation mutagenesis screens of the fourth chromosome (Hochman 1976). With the exception of defects in head morphology and defects in cuticle differentiation, none of the hemizygous deletions showed phenotypes other than those predicted by point mutations known to lie in those regions. No deletion caused new or unknown alterations in gastrulation, segmentation or cuticle pattern.These results suggest that the number of genes required zygotically for normal embryonic patterning is small and that most, if not all such loci, are represented by point mutations in our collection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848158
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  • 8
    Electronic Resource
    Electronic Resource
    The role of the peripodial membrane of leg and wing imaginal discs ofDrosophila melanogaster during evagination and differentiation in vitro (1984)
    Springer
    Development genes and evolution 193 (1984), S. 180-186 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Imaginal disc ; Morphogenesis ; Tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The thin region of the peripodial membrane is confined to the area overlying the distal anlagen in thoracic discs. During the early stages of evagination the peripodial membrane is greatly stretched, but does not rupture. The appendage then evaginates through the stalk, probably by means of a contraction of the peripodial membrane. The cells of the peripodial membrane of leg and wing discs persist and differentiate sheets of trichomes characteristic of the ventral and lateral thorax. This is discussed in relation to imaginal disc fate maps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848893
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  • 9
    Electronic Resource
    Electronic Resource
    TheUbx syndrome ofDrosophila: the prothoracic transformation (ppx) is independent ofbx, bxd andpbx (1984)
    Springer
    Development genes and evolution 193 (1984), S. 263-265 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Biothorax complex ; Prothoracic transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary If, early in development, theUbx + gene is removed by mitotic recombination from cells of the meso-and metathoracic leg primordia, theseUbx − cells develop as in the posterior prothoracic leg. We show that this transformation, termedpostprothorax, is a discrete genetic function that is independent of other homeotic transformations such asbx, pbx orbxd, which also result from the inactivation of theUbx gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01260349
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  • 10
    Electronic Resource
    Electronic Resource
    Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster (1984)
    Springer
    Development genes and evolution 193 (1984), S. 283-295 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Larval cuticle ; Pattern formation ; Embryonic lethal mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The present report describes the recovery and genetic characterization of mutant alleles at zygotic loci on the third chromosome ofDrosophila melanogaster which alter the morphology of the larval cuticle. We derived 12600 single lines from ethyl methane sulfonate (EMS)-treatedst e orrucuca chromosomes and assayed them for embryonic lethal mutations by estimating hatch rates of egg collections. About 7100 of these lines yielded at least a quarter of unhatched eggs and were then scored for embryonic phenotypes. Through microscopic examination of unhatched eggs 1772 lines corresponding to 24% of all lethal hits were classified as embryonic lethal. In 198 lines (2.7% of all lethal hits), mutant embryos showed distinct abnormalities of the larval cuticle. These embryonic visible mutants define 45 loci by complementation analysis. For 32 loci, more than one mutant allele was recovered, with an average of 5.8 alleles per locus. Complementation of all other mutants was shown by 13 mutants. The genes were localized on the genetic map by recombination analysis, as well as cytologically by complementation analysis with deficiencies. They appear to be randomly distributed along the chromosome. Allele frequencies and comparisons with deficiency phenotypes indicate that the 45 loci represent most, if not all, zygotic loci on the third chromosome, where lack of function recognizably affects the morphology of the larval cuticle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848157
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  • 11
    Electronic Resource
    Electronic Resource
    Early neurogenesis in wild-typeDrosophila melanogaster (1984)
    Springer
    Development genes and evolution 193 (1984), S. 308-325 
    Details
    ISSN: 1432-041X
    Keywords: Neurogenesis ; Pattern of neuroblasts ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary This paper deals with morphological aspects of early neurogenesis inDrosophila, in particular with the segregation of neuroblasts from the neurogenic region of the ectoderm and the pattern formed by those wells within both the germ band and the procephalic lobe. The neurogenic ectoderm was found to contain neural precursors intermingled with epidermal precursors, extending from the midline up to the primordia of the tracheal tree along the germ band and laterodorsally in the procephalic lobe. Germ band neuroblasts segregate from the neurogenic ectoderm during a period of several hours according to characteristic spatial and temporal patterns. During the first half of the segregation process the pattern of germ band neuroblasts was found to be the same in different animals in both spatial arrangement and number of cells; this permitted the identification of individual neuroblasts from different embryos. Later in development several difficulties were encountered which precluded an exact description of the neuroblast pattern. The constitution of the neurogenic region is discussed in relation to the phenotype of mutants affecting neurogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848159
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  • 12
    Electronic Resource
    Electronic Resource
    The spatial arrangement of germ line cells in ovarian follicles of the mutantdicephalic inDrosophila melanogaster (1984)
    Springer
    Development genes and evolution 193 (1984), S. 388-393 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Oogenesis ; Ring canals ; Oocyte determination ; Polarity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The pattern of intercellular connections between germ line cells has been studied in follicles of the mutantdicephalic (dic), which possess nurse cell clusters at both poles. Staining of follicles with a fluorescent rhodamine conjugate of phalloidin reveals ring canals and cell membranes and thus allows us to reconstruct the spatial organization of the follicle. Each germ line cell can be identified by the pattern of cell-cell connections which reflect the mitotic history of individual cells in the 16-cell cluster. The results indicate that in both wild-type anddicephalic cystocyte clusters one of the two cells with four ring canals normally becomes the pro-oocyte. However, in some follicles (dicephalic and wild-type) oocytes were found with fewer or more than four ring canals. Indic follicles, one or several nurse cells may become disconnected from the other cells during oocyte growth at stage 9–10. Such disconnected cells cannot later on empty their cytoplasm into the oocyte. This, in turn, might be of consequence for the determination of axial polarity of the embryo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848229
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  • 13
    Electronic Resource
    Electronic Resource
    Cell interactions during the fusionin vitro ofDrosophila eye-antennal imaginal discs (1984)
    Springer
    Development genes and evolution 193 (1984), S. 406-413 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Imaginal disc ; Morphogenesis ; Tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The fusion of the eye-antennal discs during culturein vitro has been investigated, and the complex morphogenetic movements which occur during the formation of the head capsule of the insect are described. The initial contact between the eye anlagen is by means of cell processes spanning the gap between the two discs. Subsequently the two epithelia become firmly apposed, and then the integrity of the epithelium in the region of fusion breaks down, cells appearing to move to new positions in order to form an epithelium which unites the two discs. The epithelium eventually secretes a pattern of cuticular structures which is continuous between the derivatives of the two discs. Bristles on either side of the line of fusion are perfectly aligned, and structures such as the median ocellus, which are formed jointly by the cells of the two discs, differentiate normally. This is also found when left and right eye-antennal discs of different genotypes are placed side-by-side, indicating that processes of pattern regulation can occur in culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848232
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  • 14
    Electronic Resource
    Electronic Resource
    Relationship between the cardiovascular effects and steady-state kinetics of clonidine in hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 309-313 
    Details
    ISSN: 1432-1041
    Keywords: clonidine ; hypertension ; therapeutic window ; steady state concentration ; pharmacokinetics ; cardiovascular effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clonidine was given orally as monotherapy in increasing daily doses from 3.1 to 25.7 µg/kg to patients with essential hypertension (n=6). When a steady state concentration in plasma was reached at each dose level, the blood pressure (BP) and heart rate were measured during a dosage interval. Effect time — plasma concentration data were submitted to nonlinear regression analysis, which showed that the observed BP effects could be dissociated into depressor and pressor components. A window for the antihypertensive effect was established. At a plasma clonidine concentration of 0.65±0.07 ng/ml 50% of the maximal depressor effect was found, and it was only separated by a factor of 2 from the half maximal pure pressor concentration in plasma. No relationship between the change in heart rate and the plasma clonidine was observed. The findings strengthen the importance of close monitoring of clonidine therapy.
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    URL: http://dx.doi.org/10.1007/BF00548760
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  • 15
    Electronic Resource
    Electronic Resource
    Effect of oxprenolol and metoprolol on serum lipid concentration (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 331-334 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; oxprenolol ; hypertension ; beta-blockers ; HDL-cholesterol ; intrinsic sympathomimetic activity ; cardioselectivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aim of the present study was to evaluate whether a reduction in HDL-cholesterol is peculiar to non cardioselective beta blockers or whether it is also produced by cardioselective beta1-blockers. 16 patients with primary arterial hypertension on a balanced isocaloric diet were given oxprenolol 120 to 240 mg/day or metoprolol 100 to 200 mg/day in a random cross-over study. No significant change was observed after either treatment in fasting blood glucose, serum total cholesterol and triglycerides. HDL-cholesterol concentration was significantly decreased on metoprolol, from 41 to 36 mg/dl (p〈0.05), while oxprenolol did not affect it at all. The difference might depend on intrinsic sympathomimetic activity which is possessed by oxprenolol and which metoprolol lacks.
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    URL: http://dx.doi.org/10.1007/BF00548763
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  • 16
    Electronic Resource
    Electronic Resource
    Pafenolol, a new β1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 549-553 
    Details
    ISSN: 1432-1041
    Keywords: pafenolol ; hypertension ; antihypertensive therapy ; beta1-blocking agent ; exercise tests ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Pafenolol, a new selective adrenergic beta1-blocking agent, has been tested for the first time in 6 hypertensive patients. After single oral doses of pafenolol 25 to 100 mg, there was a marked reduction in heart rate and systolic blood pressure during exercise tests. These effects were dose dependent. A significant positive correlation was found between the reduction in heart rate during exercise and the plasma level of pafenolol 5 hours after drug intake (correlation coefficient r=0.94). Side effects were mild and seemed to be dose dependent. It is concluded that this new beta1-blocking agent was effective in reducing blood pressure and was well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543483
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  • 17
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    Electronic Resource
    Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 687-693 
    Details
    ISSN: 1432-1041
    Keywords: etozolin ; ozolinone ; furosemide ; hypertension ; renin ; catecholamines ; chronic renal failure ; steady state kinetics ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect on urinary electrolyte excretion, renin release and plasma norepinephrine of single oral doses of 400 mg etozolin (E) and of 40 mg furosemide (F) were studied in hypertensive patients with normal (n=6) and impaired kidney function (n=6). E caused a marked saluresis up to 24 hours, showing its long duration of action. F, however, displayed a brief, brisk peak diuresis, followed by a rebound from the 4th to the 24th hours. The brisk peak diuresis induced by F was associated with pronounced release of renin, almost twice that induced by E. In chronic renal failure the renin release in relation to the magnitude of the diuresis was increased, i.e. the sensitivity of these patients to changes in water homeostasis was increased. E and F stimulated the sympathetic system to roughly the same extent. Patients with essential hypertension had higher plasma levels of norepinephrine than hypertensive patients with chronic renal failure. In addition, hypertensive patients with normal renal function (n=4) and varying degrees of renal impairment (n=11) were also given 400 mg daily for 2 weeks. Effects on blood pressure and electrolyte homeostasis were monitored, as well as the plasma kinetics of metabolite I, ozolinone. At the end of the 2 week treatment E had significantly lowered systolic (−12 mm Hg) and diastolic (−9 mm Hg) blood pressure, and had produced a significant loss of body weight, without altering plasma electrolytes or blood chemistry. There was no accumulation of the effective metabolite ozolinone under conditions of severe impairment of kidney function. It is concluded that E can effectively control high blood pressure in patients with normal and impaired kidney function. Its effective metabolite ozolinone did not accumulate in chronic renal failure.
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    URL: http://dx.doi.org/10.1007/BF00541926
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  • 18
    Electronic Resource
    Electronic Resource
    Once daily indapamide in the treatment of the elderly and young hypertensive (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 397-405 
    Details
    ISSN: 1432-1041
    Keywords: indapamide ; hypertension ; cardiovascular reflexes ; diuretic effect ; blood pressure variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine elderly and 11 young hypertensives underwent continuous ambulatory monitoring of blood pressure (BP), assessment of cardiovascular reflexes and M-mode echocardiography as hospital in-patients prior to treatment with once-daily indapamide (2.5 mg). They were followed as out-patients for 4 months during which time casual BP was measured at monthly intervals. The patients were then readmitted to hospital and studied using the same protocol under similar standardised conditions. The results showed that indapamide reduced casual and ambulatory BP in both young and elderly although the most marked effect was seen on systolic BP. Assessment of cardiovascular reflexes indicates that at least part of the hypotensive action of indapamide is due to a diuretic effect. Treatment with indapamide has comparable results on both young and elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00549585
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  • 19
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    Electronic Resource
    Long-term effects of captopril on renal function in hypertensive patients (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 315-323 
    Details
    ISSN: 1432-1041
    Keywords: captopril ; hypertension ; glomerular filtration ; para-aminohippuric acid ; renal function ; severe drug reaction ; nephrotic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of captopril up to 450 mg/day on blood pressure and renal function were investigated during sustained treatment of 10 patients whose severe hypertension had not responded to previous therapy. All the patients were kept on diuretics and most of them on β-blockers, too. A control determination of glomerular filtration rate (GFR) and para-aminohippuric acid clearance (CPAH) was performed during the prior treatment. The effect of the addition (or substitution) of captopril were assessed after an average of 25 days (short-term) and 26 weeks (long-term). Short-term treatment produced a 15.5% decrease in mean blood pressure and interindividually variable effects on renal function. On average GFR was somewhat lower and CPAH slightly higher than the control values (not significant). This pattern is quite similar to the effects of most other antihypertensive drugs. On long-term therapy GFR rose by a mean of 9% (NS) and CPAH by 17% (p〈0.02). However, in a patient who developed a captopril-induced nephrotic syndrome, GFR dropped to 56% and CPAH to 50% of the control values. In another patient a transient rise in serum creatinine accompanied a severe drug reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548761
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  • 20
    Electronic Resource
    Electronic Resource
    Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 13-17 
    Details
    ISSN: 1432-1041
    Keywords: beta-blocking drugs ; insulin sensitivity ; pancreatic beta-cell function ; hypertension ; propranolol ; atenolol ; insulin secretion ; plasma GIP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of two beta-blocking drugs on endogenous insulin secretion and insulin sensitivity were investigated in a double blind cross-over study in 13 hypertensive patients. The patients were randomly allocated to each of three 2-week treatment periods with propranolol 80 mg b.i.d., atenolol 50 mg b.i.d. and placebo b.i.d. Endogenous insulin secretion was assessed by measuring serum insulin and C-peptide before and 6 min after iv administration of glucagon; insulin sensitivity was determined by measuring insulin binding to erythrocytes, and as the glucose disappearance rate (KITT) after i.v. insulin. Fasting concentrations of serum free fatty acids (S-FFA) and plasma gastric inhibitory polypeptide (P-GIP) were also recorded during the three study periods. Both propranolol and atenolol reduced blood pressure, heart rate and S-FFA concentrations compared to placebo, and all patients showed measurable plasma concentrations of propranolol and atenolol. The results can be considered representative, therefore, of clinical beta-blockade. The two drugs did not significantly influence the fasting blood glucose level. There was an increase in fasting and glucagon-stimulated serum C-peptide concentration during propranolol therapy compared with placebo (p=0.037 and p=0.030, respectively), although this was not reflected by a significant change in serum insulin. Propranolol and atenolol did not significantly influence insulin binding to erythrocytes, but they clearly reduced the glucose disappearance rate KITT was compared to placebo (p=0.0036 and p=0.0003, respectively). The findings support the view that beta-blocking drugs can influence glucose metabolism by mechanisms other than inhibition of endogenous insulin secretion.
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    URL: http://dx.doi.org/10.1007/BF00546701
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  • 21
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    Should the acetylator phenotype be determined when prescribing hydralazine for hypertension? (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 39-42 
    Details
    ISSN: 1432-1041
    Keywords: acetylator phenotype ; hydralazine response ; hypertension ; blood pressure control ; lupus syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and β-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p〈0.01). Despite higher doses of hydralazine the blood pressure was controlled in only 27% of rapid acetylators compared to 65% of slow acetylators (p〈0.02). The relation of acetylator phenotype to blood pressure response was statistically independent of initial blood pressure, age, sex, body weight and serum creatinine (p〈0.005). Current recommendations on hydralazine dosage are unsatisfactory for the 40% of hypertensive patients who are rapid acetylators. We suggest measurement of the acetylator phenotype in patients who respond incompletely to 200 mg hydralazine daily. About 70% of these patients will be rapid acetylators in whom the dose of hydralazine can be increased safely.
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    URL: http://dx.doi.org/10.1007/BF00546706
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  • 22
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    Electronic Resource
    Comparison of methods to detect side-effect on clinical application of chloranolol, a beta-adrenergic receptor inhibitor (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 555-562 
    Details
    ISSN: 1432-1041
    Keywords: Tobanum® ; beta-blocker ; chloranolol ; hypertension ; angina pectoris ; arrhythmia ; detection methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The incidence of side-effects on administration of chloranolol (Tobanum®), a beta-adrenergic receptor blocking drug, to 2066 patients with hypertension, angina pectoris or arrhythmias was measured by three different methods. In 600 patients in an efficacy trial (Group 1) both spontaneously reported complaints and objective signs were tabulated. A side effect — directed method, utilising a questionnaire containing a list of possible side-effects was also used, with the questionnaire being completed by the physician. 35 questions referred to anticipated and other side-effects. The trial was performed in two groups: in 537 patients a placebo was also given (Group 2), and in another set of 929 patients (Group 3) the questionnaire inquiry was performed uncontrolled, without placebo. All three groups were comparable in their distribution of sexes, ages and diagnoses, the mean daily dose of chloranolol its use alone or in combination, and in a similar duration of treatment. 55% of all patients received chloranolol therapy for a period of more than 3 months. The ratio of in- and outpatients was 1:5. The side-effect incidence was independent of the age and sex of the patients and of the dose of chloranolol. The incidence was also unaffected whether chloranolol was used alone or in combination. The number of side-effects differed markedly between the three groups, their ratio was 1:10:24 in Groups 1, 2 and 3. Two-thirds of the side-effects subsided spontaneously within 1 month of their onset. The duration of the side-effects varied according to their character: cardiorespiratory side-effects were of the shortest duration and those affecting the central nervous system were the most enduring. The appreciable differences in incidence could be attributed to the methods of collection of the data. It has been stated that placebo controlled trials using a detailed questionnaire are the most suitable for estimating the incidence of side-effects; recording side-effects spontaneously reported by patients are insufficiently sensitive, and uncontrolled trials using a questionnaire have been shown to be too sensitive. The revealed incidence of side effects leading to interruption of treatment is less affected by the method chosen. In 100 patients (4.8%) therapy had to be suspended because of the side-effects of chloranolol (Group 1: 1%, Group 2: 6.20%, Group 3: 6.6%). Comparison of the incidence of cessation of therapy due to side-effects did not show an appreciable difference between the various beta-adrenergic receptor blocking agents, including chloranolol.
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    Propranolol vs metoprolol vs labetalol: A comparative study in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 1-6 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; beta-blockers ; propranolol ; metoprolol ; labetalol ; exercise ; heart rate ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind, within patient investigation of twenty-four patients (nineteen males and five females) with a mean age of 46.3 years (SD 10.9 years) with mild to moderate essential hypertension a comparison between equipotent beta-blocking doses of propranolol, metoprolol and labetalol was carried out. Blood pressure and pulse rate were measured in lying, sitting and standing positions and before, during and after isometric and dynamic exercise. Peak expiratory flow was recorded before and during dynamic exercise. All the active treatments were better than placebo in reducing blood pressure and heart rate. Comparing the effects of treatment, labetalol lowered sitting diastolic pressure significantly more than propranolol and standing diastolic pressure than both propranolol and metoprolol. Metoprolol and propranolol were more effective in reducing heart rate. Propranolol significantly reduced peak flow rate compared to labetalol. During the exercise, both isometric and dynamic, the heart rate and the blood pressure, both systolic and diastolic, of the treated patients were lower than those on placebo. There was little difference between the drugs in the influence on blood pressure, but metoprolol and propranolol were significantly more effective than labetalol in lowering the heart rate.
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    URL: http://dx.doi.org/10.1007/BF00546699
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  • 24
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    Reduced peripheral vascular symptoms in elderly patients treated with α-methyldopa — A comparison with propranolol (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 325-329 
    Details
    ISSN: 1432-1041
    Keywords: alpha-methyldopa ; propranolol ; hypertension ; side effects ; blood pressure control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A multicentre study of 6–10 weeks duration was performed in 60 ambulant hypertensive patients aged over 60 years to compare the efficacy of methyldopa and propranolol with particular reference to the occurrence of cold extremities and sleep disturbances. Blood pressure was effectively controlled by both drugs being reduced from a mean of 180/108 mmHg to 161/93 with methyldopa and 180/108 to 162/94 with propranolol. More patients treated with methyldopa (74%) achieved the target diastolic blood pressure of 95 mmHg or below compared with those treated with propranolol (58%). Side effects were more frequent in the propranolol group necessitating the withdrawal of four patients from the study. Only one patient on methyldopa was withdrawn. The incidence of cold extremities was significantly greater with propranolol. The occurrence of sleep disturbances was similar in both groups. In this group of elderly patients methyldopa was better tolerated than propranolol.
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    URL: http://dx.doi.org/10.1007/BF00548762
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  • 25
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    Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 543-547 
    Details
    ISSN: 1432-1041
    Keywords: indapamide ; hypertension ; glomerular filtration ; arginine vasopressin ; free water clearance ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Renal plasma flow (RPF), glomerular filtration rate (GFR), arginine vasopressin in plasma (AVP), free water clearance ( $${\text{C}}_{{\text{H}}_{\text{2}} {\text{O}}}$$ ) and blood pressure (BP) were determined in 11 patients with essential hypertension at the end of 3 consecutive periods of observation each of 6 of weeks duration; indapamide 2.5 mg daily was given in period 2 and placebo in periods 1 and 3. RPF and GFR were reduced by 9% and BP by 9%/14% supine and 14%/12% standing during indapamide treatment. Changes in renal haemodynamics were not correlated with those in BP. AVP was not significantly altered by indapamide and was not correlated with BP. Indapamide reduced $${\text{C}}_{{\text{H}}_{\text{2}} {\text{O}}}$$ possibly due to the reduction in GFR. It is concluded that indapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions.
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  • 26
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    Is the feeling of cold extremities experienced by hypertensive patients due to their disease or their treatment? (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 47-49 
    Details
    ISSN: 1432-1041
    Keywords: beta-blockers ; hypertension ; ISA ; CS ; cold extremities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Patients with essential hypertension were interviewed prior to entering therapeutic studies in general practice. Patients' age, sex and details of antihypertensive therapy (if any) were noted, as were their spontaneously reported symptoms. Complaints of cold extremities were highest in those taking a beta-blocker (4.1%). Those untreated or taking other therapies complained less often. Those patients taking a beta-blocker with ISA complained less often (3.1%) of cold extremities than those taking a beta-blocker without ISA (5.2%).
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    URL: http://dx.doi.org/10.1007/BF00553153
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    Long acting nifedipine in the treatment of severe hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 13-17 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; hypertension ; blood pressure decrease ; drug combination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.
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    URL: http://dx.doi.org/10.1007/BF02395199
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  • 28
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    Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 23-27 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; alpha2-adrenoceptors ; blood pressure ; clonidine ; guanfacine ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time courses of the changes in plasma growth hormone and noradrenaline concentrations in response to 15 min infusions of clonidine 0.2 mgs and guanfacine 2 mgs, were studied in six normal volunteers, in a double-blind, randomised, crossover study. Plasma noradrenaline fell within 15 min of the commencement of drug administration, by 36±14% after clonidine (p〈0.05) and by 32±11% (p〈0.05) after guanfacine. Plasma growth hormone was not significantly elevated until the 30th minute to 12.0±4.7 lU/ml (p〈0.05) after clonidine and 14.7±11.5 lU/ml (p〈0.05) after guanfacine, having been undetectable prior to both drugs. The reduction in plasma noradrenaline by these α2-adrenergic agonists, prior to activation of central adrenoceptors as detected by changes in plasma growth hormone, is evidence for a peripheral component in their sympatholytic effect.
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    URL: http://dx.doi.org/10.1007/BF02395201
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  • 29
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    Electronic Resource
    Crossover comparison of moxonidine and clonidine in mild to moderate hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 147-152 
    Details
    ISSN: 1432-1041
    Keywords: moxonidine ; clonidine ; hypertension ; double-blind crossover ; side-effects ; withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive effect of moxonidine·HCl·H2O (MOX) was compared with that of clonidine·HCl (CLON) in a randomized double-blind crossover study in 20 hypertensive outpatients (BP range 154–178/96–108 mmHg). After 2 weeks without antihypertensive medication, either MOX 0.2 mg daily or CLON 0.2 mg daily was given and the dose was titrated until the diastolic blood pressure fell below 90 mmHg. The first treatment period was continued for 2 weeks and, after crossover without a wash-out period, it was followed by the second treatment for a further 2 weeks. Within the first 4 days of administration 0.2–0.4 mg of either agent caused a significant decrease in BP (p〈0.001) from a mean of 166/100 mmHg to 149/86 mmHg after CLON (approx. −10/−14%), and 163/99 mmHg to 146/84 mmHg after MOX (approx. −10/−15%). No significant difference in the fall in BP or pulse rate was detected between the two drugs. In the mean daily dose of 0.3 mg both drugs showed the same antihypertensive activity, but on CLON a higher incidence of side effects (p=0.003) was noted, and after discontinuation of therapy a more rapid rise in BP (systolic BP p〈0.01, diastolic BP p〈0.02) was found. 17 patients on CLON complained of side effects, especially tiredness and dry mouth, whilst only 6 patients on MOX were affected (p=0.003).
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    URL: http://dx.doi.org/10.1007/BF00544037
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  • 30
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    Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 393-396 
    Details
    ISSN: 1432-1041
    Keywords: guanfacine ; hydrallazine ; hypertension ; sympathetic nervous activity ; plasma renin activity ; cardiac and systemic haemodynamics ; blood pressure ; limb blood flow ; limb vascular resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of guanfacine and hydrallazine on cardiovascular haemodynamics and on sympathetic nervous activity has been studied in 16 patients with essential hypertension. Two groups of patients were investigated: in Group A guanfacine brought the blood pressure back to normal (diastolic blood pressure ⩽90 mmHg), and in Group B diastolic blood pressure was 〉 90 mmHg and required the addition of hydrallazine. Guanfacine significantly decreased heart rate, plasma renin activity and urinary excretion of noradrenaline, without altering cardiac contractility. In Group B, guanfacine 2 to 6 mg/day produced a significant decrease in blood pressure from 178.7/112.4 to 164.4/102.9 mmHg and in heart rate from 77.1 to 62.7 beats/min after 4 weeks of treatment. Guanfacine did not significantly alter preejection period, cardiac output or total peripheral resistance. Hydrallazine 50 to 300 mg/day caused a further reduction in blood pressure from 164.4/102.9 to 150.7/90.2 mmHg and an increase in heart rate from 62.7 to 72.1 beats/min. Limb blood flow was increased from 4.55 to 5.93 ml/100 g/min and limb vascular resistance was decreased from 39.55 to 23.6 mmHg 100 g·min/ml. Hydrallazine also caused a slight increase in plasma renin activity and urinary excretion of noradrenaline. It is concluded that guanfacine is a useful agent to block a hydrallazine-induced increase in sympathetic nervous activity.
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    URL: http://dx.doi.org/10.1007/BF00549584
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  • 31
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    Piretanide, a potassium stable diuretic, in the treatment of essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 407-414 
    Details
    ISSN: 1432-1041
    Keywords: piretanide ; hypertension ; triamterene ; double blind comparison ; potassium ; magnesium ; side-effects ; serum electrolytes ; serum parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomized, double blind, parallel group study in out patients with mild to moderate essential hypertension the effects of piretanide on serum electrolytes and on blood pressure were compared with those of triamterene alone and the combination piretanide + triamterene. 136 patients entered the study; 18 patients did not fulfill the inclusion criteria (RRdiast was below 95 mmHg or above 120 mmHg) at the end of the placebo period, 6 dropped out due to side effects, and 1 due to lack of efficacy. Data from 1 patient were not evaluated because the patient did not come regularly for checkups. The results for 110 patients were analyzed. Piretanide 6 mg b.d. and piretanide 6 mg + triamterene 50 mg b.d. produced a significant reduction both in supine and erect blood pressure, which was evident at 2 weeks and which increased over the ensuing 12 week trial period. A mean maximal fall of 16.5% was noted in the piretanide group and 15% in the piretanide + triamterene group. Triamterene alone (50 mg b.d.) also reduced diastolic and systolic blood pressures but the reduction was significantly less (diastolic blood pressure) than in both the piretanide groups, and it showed a more rapid return to pretreatment level during a placebo washout phase at the end of the study. A reduction in standing diastolic blood pressure below 95 mmHg was attained in 84% of patients in the piretanide group, 82% in the piretanide + triamterene group and in only 58% of the triamterene group. There were no significant changes within groups nor differences between the three groups in serum potassium or magnesium. 7 patients were withdrawn from the study because of side-effects due to too marked a clinical action (polyuria, orthostatic disorders and hypotension), one from the piretanide group, and the others in the piretanide + triamterene group. One patient in the triamterene group left the study prematurely due to the lack of effect.
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    Double-blind comparison of once-daily bopindolol, pindolol and atenolol in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 529-534 
    Details
    ISSN: 1432-1041
    Keywords: beta-adrenoceptor blocking agents ; hypertension ; adverse reactions ; atenolol ; bopindolol ; pindolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy of once-daily bopindolol, a nonselectiveβ-adrenoceptor blocking agent with partial agonist activity, and of pindolol and atenolol in the treatment of essential hypertension has been compared. 369 patients were investigated in a double-blind parallel-group study. The treatment period was 10 weeks. Blood pressure normalisation (diastolic BP equal to or less than 90 mmHg) was to be achieved by a stepwise increase in the dose of the test drugs, and, if required, by addition of a diuretic. Normalisation of blood pressure was achieved in 71 to 76% of the subjects, with no significant differences between bopindolol, pindolol, and atenolol. Special attention was given to evaluation of side effects by using two methods for registration of all adverse events during the study. A low incidence of drug-induced side effects was observed, with no significant difference between bopindolol, pindolol, and atenolol. There was no evidence of unsuspected adverse reactions due to bopindolol.
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  • 33
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    Comparison of hydrochlorothiazide and atenolol as initial treatment in uncomplicated hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 157-162 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; hydrochlorothiazide ; atenolol ; side effects ; therapeutic efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary After screening a local population in the northern part of The Netherlands for hypertension, 119 patients with a diastolic pressure (DP) between 95 and 120 mmHg were randomised and treated either with 50 mg hydrochlorothiazide (n=59) or 100 mg atenolol (n=60). After 1 month of treatment 6 patients in the hydrochlorothiazide group and 24 patients in the atenolol group had reached a DP⩽90 mmHg (p〈0.001). 43 of the 50 non-responders to hydrochlorothiazide were switched to atenolol and 30 of the 35 non-responders to atenolol were changed to hydrochlorothiazide. One month after the switch 19 patients in the atenolol group and 2 patients in the hydrochlorothiazide group had reached a DP⩽90 mmHg (p〈0.001). After 6 months of treatment 32 of the 43 atenolol responders and 7 of the 8 hydrochlorothiazide responders were still receiving the same medication, as their DP was still⩽90 mmHg. Non-responders to either medication were given the combination (n=46). 21 patients now became normotensive as did a further 10 after increasing the dose of atenolol to 200 mg. Thus, in all 70 patients had a blood pressure ⩽90 mmHg after treatment for 4 months. Both drugs induced a significant reduction in the total of number of complaints after 1 month of treatment. They did not differ from each other. The reduction was seen both in responders and non-responders and persisted during treatment for 6 months. It is concluded that in terms of short-term efficacy the cardioselective, hydrophilic beta adrenoceptor-blocking drug atenolol is preferable to hydrochlorothiazide in the treatment of uncomplicated hypertension.
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    URL: http://dx.doi.org/10.1007/BF00630280
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    Pharmacokinetics and hypotensive effect in healthy volunteers of pinacidil, a new potent vasodilator (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 603-608 
    Details
    ISSN: 1432-1041
    Keywords: pinacidil ; hypertension ; pinacidil pyridine-N-oxide ; urinary excretion ; protein binding ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Preliminary investigation in 3 healthy volunteers suggested that intravenous pinacidil in a dose of 0.2 mg/kg had a potent but well-tolerated hypotensive action in the supine position. Facial flushing, uncomfortable chest sensation and distressing postural hypotension occurred at serum concentrations above 300 ng/ml. Pinacidil, 0.2 mg/kg, was given intravenously over 4 min to 15 healthy volunteers in the supine position. Maximum fall in mean arterial pressure (MAP) was 15.7±6.0 mmHg. Maximum rise in heart rate was 23.8±6.6 beats/min. Pinacidil serum distribution half-life ( $${\text{T}}_{{\raise0.7ex\hbox{${\text{1}}$} \!\mathord{\left/ {\vphantom {{\text{1}} {{\text{2}}\alpha }}}\right.\kern-\nulldelimiterspace}\!\lower0.7ex\hbox{${{\text{2}}\alpha }$}}}$$ ) was 13.4±8.5 min and elimination half-life ( $${\text{T}}_{{\raise0.7ex\hbox{${\text{1}}$} \!\mathord{\left/ {\vphantom {{\text{1}} {{\text{2}}\beta }}}\right.\kern-\nulldelimiterspace}\!\lower0.7ex\hbox{${{\text{2}}\beta }$}}}$$ ) was 2.13±0.49 h. The apparent volume of distribution (Vdβ) was 90.3±13.21 and total body clearance was 31.1±9.61/h. Pinacidil was approximately 40% bound to plasma protein over the concentration range 40–400 ng/ml. Urinary excretion of unchanged pinacidil accounted for 5.7 ± 1.3% of the administered dose over 24 hours and urinary excretion of the major metabolite, pinacidil pyridine-N-oxide, was 31.6±9.2% of the administered dose. It was concluded that intravenous pinacidil is a potent vasodilator hypotensive compound, with a duration of action between 1.5 and 2 h.
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    Pharmacokinetics of endralazine (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 661-661 
    Details
    ISSN: 1432-1041
    Keywords: endralazine ; hypertension ; elimination half-liefe ; compartment model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
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    URL: http://dx.doi.org/10.1007/BF00543509
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    Long acting nifedipine in the treatment of severe hypertension (1984)
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    European journal of clinical pharmacology 27 (1984), S. 13-17 
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    ISSN: 1432-1041
    Keywords: nifedipine ; hypertension ; blood pressure decrease ; drug combination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.
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    Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 23-27 
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    ISSN: 1432-1041
    Keywords: hypertension ; alpha2-adrenoceptors ; blood pressure ; clonidine ; guanfacine ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time courses of the changes in plasma growth hormone and noradrenaline concentrations in response to 15 min infusions of clonidine 0.2 mgs and guanfacine 2 mgs, were studied in six normal volunteers, in a double-blind, randomised, crossover study. Plasma noradrenaline fell within 15 min of the commencement of drug administration, by 36±14% after clonidine (p〈0.05) and by 32±11% (p〈0.05) after guanfacine. Plasma growth hormone was not significantly elevated until the 30th minute to 12.0±4.7 lU/ml (p〈0.05) after clonidine and 14.7±11.5 lU/ml (p〈0.05) after guanfacine, having been undetectable prior to both drugs. The reduction in plasma noradrenaline by these α2-adrenergic agonists, prior to activation of central adrenoceptors as detected by changes in plasma growth hormone, is evidence for a peripheral component in their sympatholytic effect.
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    Is the feeling of cold extremities experienced by hypertensive patients due to their disease or their treatment? (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 47-49 
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    ISSN: 1432-1041
    Keywords: beta-blockers ; hypertension ; ISA ; CS ; cold extremities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Patients with essential hypertension were interviewed prior to entering therapeutic studies in general practice. Patients’ age, sex and details of antihypertensive therapy (if any) were noted, as were their spontaneously reported symptoms. Complaints of cold extremities were highest in those taking a beta-blocker (4.1%). Those untreated or taking other therapies complained less often. Those patients taking a beta-blocker with ISA complained less often (3.1%) of cold extremities than those taking a beta-blocker without ISA (5.2%).
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    Pinacidil, a new vasodilator, in the treatment of patients with moderate to severe hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 287-289 
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    ISSN: 1432-1041
    Keywords: pinacidil ; hypertension ; vasodilator ; patients ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A new vasodilator drug, pinacidil, N″-cyano-N-4-pyridyl-N′-1, 2,2-trimethylpropylguanidine, was studied in an open trial in 15 patients with moderate to severe hypertension. Four patients received pinacidil monotherapy, and in 11 patients it was used with a diuretic or a beta-blocker. In all but one patient normotension was achieved with a mean daily pinacidil dose of 46.7 mg b.i.d. (range 20–100 mg). Side effects were few and were action-related. There was no evidence of early toxicity. Pinacidil is a promising new antihypertensive vasodilator, which deserves further clinical evaluation.
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    Variation in the biochemical properties of the Drosophila alcohol dehydrogenase allozymes (1984)
    Springer
    Biochemical genetics 22 (1984), S. 153-168 
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    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase ; Drosophila ; activity ratio ; specific activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Thirteen Drosophila Adh variants have been characterized with respect to gene expression, substrate preference, thermostability, and specific activity. The results suggest that the variants may be grouped into two biochemical classes, typified by the properties of the two most common enzyme forms, ADH-F and ADH-S. Membership of these classes cannot be predicted from electrophoretic mobility, nor is any simple classification possible with regard to the characteristics of level of gene expression (in terms of ADH activity or ADH protein) or thermostability of the gene product.
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    Acetaldehyde utilization and toxicity in Drosophila adults lacking alcohol dehydrogenase or aldehyde oxidase (1984)
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    Biochemical genetics 22 (1984), S. 1015-1029 
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    ISSN: 1573-4927
    Keywords: acetaldehyde ; alcohol dehydrogenase ; aldehyde oxidase ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Metabolic utilization and toxicity of acetaldehyde were studied in flies lacking alcohol dehydrogenase (ADH), aldehyde oxidase (AO), or both functions. Prior to the experiments, mutant alleles Adh n4 and mal were transferred to the same genetic background by 10 successive backcrosses. By comparison with wild-type flies, various deleterious, pleiotropic effects could be attributed to the mal allele but not to Adh n4 . Of the four genotypes studied (mal, Adh n4 , mal Adh n4 , and wild), all were able to use acetaldehyde as a resource in a similar way. In spite of its high toxicity, acetaldehyde appeared a better resource than ethanol. Flies treated with intermediate acetaldehyde concentrations (around 0.5%) exhibited a very high interindividual heterogeneity which could reflect a physiological adaptation occurring as a consequence of the aldehyde treatment. Toxicity tests showed that ADH-negative flies were more sensitive to acetaldehyde than wild type, but this is most likely explained by the transformation of the aldehyde into alcohol. Our results show that the aldehyde metabolizing enzyme (AME) system in Drosophila is neither ADH nor AO. The existence of an aldehyde dehydrogenase is plausible.
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  • 42
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    Correlated response to phototactic selection (1984)
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    Behavior genetics 14 (1984), S. 279-293 
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    ISSN: 1573-3297
    Keywords: phototaxis ; Drosophila ; correlated response ; selection ; sepia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Artificial selection for positive and negative phototaxis was conducted in populations ofDrosophila melanogaster that were polymorphic at thesepia locus. Photoselection response was accompanied by a correlated response in the frequency of thesepia allele. Changes insepia frequency were shown to be significantly different from those predicted by several neutral models. Implications of this correlated response are briefly discussed in terms of the neurogenetic basis of phototaxis.
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    A note on barometric pressure and behavior inDrosophila pseudoobscura (1984)
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    Behavior genetics 14 (1984), S. 315-317 
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    ISSN: 1573-3297
    Keywords: Drosophila ; mating and barometric pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract During a study ofDrosophila mating behavior we observed unexpected changes in performance under ostensibly identical experimental conditions. We related the behavior during the 17 days of the experiment to changes in ambient humidity and barometric pressure. Humidity had no significant effect, but reduced barometric pressure was found to be associated with reduced mating activity (R 2=0.29,P〈0.025), accounting for close to 30% of the variation in total number of matings.
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    Genetic elements of courtship inDrosophila: Mosaics and learning mutants (1984)
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    Behavior genetics 14 (1984), S. 383-410 
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    ISSN: 1573-3297
    Keywords: Drosophila ; courtship ; learning ; circadian
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
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    URL: http://dx.doi.org/10.1007/BF01065442
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    Genetic analysis of sex appeal inDrosophila (1984)
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    Behavior genetics 14 (1984), S. 411-440 
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    ISSN: 1573-3297
    Keywords: Drosophila ; courtship ; pheromones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
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    URL: http://dx.doi.org/10.1007/BF01065443
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    Drosophila Learning: Behavior and biochemistry (1984)
    Springer
    Behavior genetics 14 (1984), S. 527-557 
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    ISSN: 1573-3297
    Keywords: Drosophila ; learning ; classical conditioning mutants ; cAMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
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    URL: http://dx.doi.org/10.1007/BF01065446
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    A few chemical words exchanged byDrosophila during courtship and mating (1984)
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    Behavior genetics 14 (1984), S. 441-478 
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    ISSN: 1573-3297
    Keywords: Drosophila ; courtship ; pheromones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Summary Experimental evidence and speculation relative to chemical messages exchanged byDrosophila during courtship and mating are reviewed. Only the speciesD. melanogaster andD. simulans are considered in detail. Emphasis is put on female aphrodisiacs, as they clearly participate in sex and species recognition. All the aphrodisiac molecules described are unsaturated long-chain hydrocarbons, and position 7 for a double bond seems important in both species. InD. melanogaster, only females are able to make 7,11-dienes, compounds which stimulate males of this species to court. InD. simulans, 7-tricosene plays a similar role but is produced by both sexes as well as maleD. melanogaster. In both species, polymorphism is shown for these molecules. Their biosynthesis is also considered and both preliminary biochemical and genetic data are introduced. Male-specific compounds which regulate male and female behaviors are also reviewed. For example,cis-vaccenyl acetate inhibits male courtship; one or two peptides control the female's receptivity and egg laying. Such compounds are transferred from males to females together with sperm.
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    A reexamination of the negative assortative mating phenomenon and its underlying mechanism inDrosophila melanogaster (1984)
    Springer
    Behavior genetics 14 (1984), S. 45-61 
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    ISSN: 1573-3297
    Keywords: assortative mating ; polymorphism ; partner selection ; pheromone ; behavior ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Averhoff and Richardson [(1974)Behav. Genet. 4:207–225] reported a trend toward negative assortative mating inDrosophila melanogaster during the course of inbreeding. These authors proposed that the underlying mechanism was based on pheromone polymorphism and male selection. Mass mating experiments were carried out to verify their hypothesis, detailed behavior observations were made to identify the underlying mechanism, and sex pheromone composition and variation were examined by using gas chromatography-mass spectrometry analysis. The results showed that negative assortative mating is not a general phenomenon. Although male pheromones are probably polymorphic, female pheromones are not. We found no evidence for male selection as predicted by Averhoff and Richardson. It is argued that the most parsimonious mechanism underlying negative assortative mating is similar to one proposed by Bryant [(1979)Behav. Genet. 9:249–256], which was based on interstrain differences in female reluctancy and male vigor.
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    The analysis of mating behavior data (1984)
    Springer
    Behavior genetics 14 (1984), S. 153-156 
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    ISSN: 1573-3297
    Keywords: mating behavior ; statistical analysis ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Quite different sets of data are shown to generate identical output ratios so that analyses of mating behavior data based on the use of input and output ratios may obscure significant aspects of the mating behavior.
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    Learning in three species of diptera: The blow flyPhormia regina, the fruit flyDrosophila melanogaster, and the house flyMusca domestica (1984)
    Springer
    Behavior genetics 14 (1984), S. 479-526 
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    ISSN: 1573-3297
    Keywords: Drosophila ; learning ; conditioning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
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    URL: http://dx.doi.org/10.1007/BF01065445
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    Chromosome variation in wheat plants regenerated from cultured immature embryos (1984)
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    Theoretical and applied genetics 67 (1984), S. 249-255 
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    ISSN: 1432-2242
    Keywords: Wheat ; Plant regeneration ; Chromosome variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A cytological study has been made of plants regenerated from cultured immature embryos of four wheat cultivars (Triticum aestivum, 2n = 6x = 42). In total, 29% of the 192 plants examined were aneuploid with a range in chromosome numbers of 38–45. Evidence of chromosome structural changes was also found. This variation occurred in regenerants of all four cultivars, but there were large differences in the proportions of aneuploids arising from individual cultures which meant that no significant differences could be demonstrated between cultivars. Chromosome abnormalities were present in plants regenerated both from embryogenic cultures and from cultures in which the origin of shoots could not be distinctly defined.
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    Wheat microspore embryogenesis during in vitro anther culture (1984)
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    Theoretical and applied genetics 67 (1984), S. 439-442 
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    ISSN: 1432-2242
    Keywords: Wheat ; Multicellular pollen grains ; Embryos ; Cytology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cytological analysis of microspore embryogenesis during in vitro culture reveals a high mortality in the first week and a latency phase of about one week before the first embryogénic mitosis. Genotypic differences observed during our wheat anther culture do not seem to originate at the induction level but are linked to the different abortion rates.
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    The regeneration of plants from frozen pollen embryos and zygotic embryos of wheat and rice (1984)
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    Theoretical and applied genetics 67 (1984), S. 525-528 
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    ISSN: 1432-2242
    Keywords: Cryopreservation ; Embryo culture ; Haploids ; Wheat ; Rice ; Germplasm bank
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Anther culture derived pollen embryos and immature zygotic embryos of wheat and rice, frozen in liquid nitrogen in the presence of dimethyl sulfoxide, sucrose and glycerol, have been revived. The retrieved cultures proliferated and/or regenerated shoots and plantlets. The prospects of the cryopreservation of embryos for the conservation and multiplication of germplasm and the possibility of the establishment of ‘Germplasm Banks’ are discussed.
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    The genetic control of grain esterases in hexaploid wheat (1984)
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    Theoretical and applied genetics 68 (1984), S. 219-226 
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    ISSN: 1432-2242
    Keywords: Hexaploid genotypes ; Allelic variation ; Esterase ; Isozymes ; Isoelectric focusing ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Analysis of grain esterase isozymes in Chinese Spring aneuploid genotypes by IEF confirmed that genes on the long arms of chromosomes 3A, 3B and 3D (Est-5) control the production of 19 isozymes. Allelic variants have been found for the isozyme pattern controlled by each chromosome. Segregational data involving null alleles and complex phenotypic differences indicate that the wheat grain esterases are encoded by three compound and probably homoeoallelic loci, each capable of producing at least six different isozymes. In a sample of 138 hexaploid genotypes, seven alleles were distinguished.
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    A computer-assisted examination of the storage protein genetic variation in 841 accessions of Triticum dicoccoides (1984)
    Springer
    Theoretical and applied genetics 69 (1984), S. 79-86 
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    ISSN: 1432-2242
    Keywords: Electrophoresis ; Endosperm ; Proteins ; Emmer ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Triticum turgidum L. var. dicoccoides (wild emmer) is an important genetic resource for increasing the protein content of common wheat (Triticum aestivum L.). Many studies have shown that the presence or absence of bands in sodium dodecyl sulfate polyacrylamide (SDS-PAGE) electrophoregrams of wheat storage proteins to be of a purely genetic character. A total protein extraction and SDS-PAGE technique was used to estimate the storage protein genetic variability among 841 accessions of wild emmer collected from various ecological regions in the Middle East. In addition, a computer data bank was developed, recording the onedimension electrophoregram bands for each accession by molecular weight (MW) and relative Coomassie Blue staining intensity as determined from densitometer scans. Analyses of this information are being used to identify specific accessions for further study by two dimension electrofocusing-electrophoresis and breeding and genetic analyses. The computer-assisted analyses indicated that the greatest genetic variability occurs for proteins in the high MW region (above 70,000 MW) followed by those in the medium range (70,000 to 33,300 MW). Comparatively little variability was revealed for protein subunits of below 33,300 MW.
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    Chromosomal assignment of genes controlling salt-soluble proteins (albumins and globulins) in wheat and related species (1984)
    Springer
    Theoretical and applied genetics 69 (1984), S. 167-172 
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    ISSN: 1432-2242
    Keywords: Chromosomal location ; Genetic control ; Salt soluble proteins ; Wheat ; Barley ; Rye
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Salt-soluble proteins from the endosperms of wheat, barley, and rye have been separated by nonequilibrium electrofocusing x electrophoresis. Genes encoding 14 of the 25 components observed in wheat have been unambiguously assigned to 10 different chromosomes (1B, 3B, 3D, 4A, 4D, 5B, 6B, 6D, 7B, 7D) by analysis of the compensated nulli-tetrasomic series. Five more wheat proteins seem to be controlled by group 2 chromosomes. Analysis of wheat-barley and wheat-rye addition lines has led to the location of genes for 6 out of 20 barley proteins in 4 different chromosomes (1H, 3H, 4H, 6H; 1H is homoeologous to group 7 chromosomes of wheat) and of genes for 5 out of 20 rye proteins in two different chromosomes (2R, 4R). The relationship between the proteins reported here and previously characterized ones is discussed.
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    Evidence for maternal effect in the inheritance of grain protein in crosses between cultivated and wild tetraploid wheats (1984)
    Springer
    Theoretical and applied genetics 67 (1984), S. 521-524 
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    ISSN: 1432-2242
    Keywords: Wheat ; Triticum ; Grain protein ; Grain weight ; Maternal effect ; Cytoplasmic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Reciprocal crosses were made between cultivated wheat (Triticum turgidum var. ‘durum’) and a high-protein line of wild tetraploid wheat (T. turgidum var. ‘dicoccoides’). F1 grains (on maternal spikes) were very similar to the selfed grains on the maternal parent in protein percentage, weight and protein content. These traits were also analyzed in F3 grains developed on F2 spikes of segregating populations derived from reciprocal crosses between the same cultivated parent and another high-protein line of var. ‘dicoccoides’. No significant differences in the mean values of these traits were found between the reciprocal crosses, indicating no cytoplasmic effect. It has been concluded that these grain characteristics are largely determined by the maternal plant.
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    Heritability of grain yield, plant height and test weight of a population of winter wheat adapted to Southwestern Ontario (1984)
    Springer
    Theoretical and applied genetics 68 (1984), S. 21-23 
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    ISSN: 1432-2242
    Keywords: Wheat ; Heritability ; Yield ; Height
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Grain yield, plant height and test weight were studied in a population of winter wheat (Triticum aestivum L.). The population consisted of F2 bulk populations of 42 crosses among 11 genotypes adapted to S. W. Ontario. Heritabilities were: 0.30±0.32 for yield, 0.77±0.15 for height and 0.98±0.08 for test weight. Predicted genetic gain with 10% selection intensity was 0.15 t/ha for yield, 10.1 cm for height and 3.00 kg/hl for test weight. The low heritability for yield indicates that effective selection would require pedigree information and progeny tests, while the high heritabilities for height and test weight indicate that selection for these traits using single plots would be appropriate.
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    Changes in β-adrenoreceptor density in intact lymphocytes of hypertensive subjects (1984)
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    Bulletin of experimental biology and medicine 98 (1984), S. 1633-1635 
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    ISSN: 1573-8221
    Keywords: hypertension ; β-adrenoreceptors ; lymphocytes ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    URL: http://dx.doi.org/10.1007/BF00802937
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    A comparison of a tissue solubilization method with a combustion method for liquid scintillation counting of14C-labelled soil (1984)
    Springer
    Plant and soil 77 (1984), S. 381-385 
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    ISSN: 1573-5036
    Keywords: 14C-labelled plant material ; 14C-labelled soil ; Root exudation ; Sample oxidizer ; Scintillation counting ; Sutton series soil ; Tissue solubilization ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A comparison between a tissue solubilization method and a sample oxidizer technique to measure14C in plant and soil material is described. The solubilization method although not quantitative gives good recoveries and reproducible values of14C-content with soil samples not exceeding 10 mg and should be of value for estimating the14C-content of soils in laboratories without a sample oxidizer.
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    The behaviour of roots encountering cracks in soil (1984)
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    Plant and soil 77 (1984), S. 141-149 
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    ISSN: 1573-5036
    Keywords: Cracks ; Crack width ; Lateral roots ; Pea ; Penetration ; Penetrometer ; Rape ; Remoulded soil ; Roots ; Safflower ; Seminal axes ; Soil strength ; Undisturbed soil ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Experimental methods are described for observing the behaviour of roots encountering cracks in soil. The proportions of roots which enter a second soil block after crossing a crack of known width were measured. Soil strength was measured with a penetrometer. Results are presented for the proportions of seminal roots of wheat and primary lateral roots of pea which enter moulded soil of various strengths after crossing cracks. Results are also presented for the proportions of seminal roots of pea, rape and safflower which enter undisturbed soil after crossing cracks. It was found that, in all cases, the proportion of roots penetrating the second soil block decreased with increasing crack width and increasing soil strength. Also, a smaller proportion of thinner roots penetrated the second soil block than thicker roots under similar conditions. Root diameter in the cracks was influenced by both crack width and soil strength, and an empirical equation is presented to describe this effect.
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    Studies on potassium release in an inceptisol soil (Holambi Series) at the minimum level of exchangeable potassium (1984)
    Springer
    Plant and soil 79 (1984), S. 3-10 
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    ISSN: 1573-5036
    Keywords: Ammonium acetate extractable potassium ; Inceptisol soil ; Minimum level ; Non-exchangeable potassium ; Pearl millet ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Ammonium acetate extractable potassium in the soil reached a minimum value of 6.8 mg K/100g soil after 14 crops of wheat and pearl millet in the field without applying any potassium fertilizer. At this level of ammonium acetate extractable K both wheat and pearl millet utilized about, 90 per cent of the total K from non-exchangeable sources. Wheat and pearl millet were grown in this soil in the greenhouse at different levels of K. At K0 level wheat utilized 86 per cent of the total K uptake from the non-exchangeable source and pearl millet, 95 per cent. At K1 level, wheat utilized only 19 per cent but at higher levels of K, there was build up in the K status of soils. In the case of pearl millet at K1, K2 and K3 levels 59, 13 and 22 per cent of total uptake were contributed by non-exchangeable forms. The total K uptake by pearl millet was more than double that by wheat. Plant analysis showed that 83 per cent of the total K in wheat was contained in the shoot portion and the rest in the roots. The corresponding figures for pearl millet were 94 and 6 per cent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182139
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    Evaluation of acid permanganate extraction as an index of soil nitrogen availability (1984)
    Springer
    Plant and soil 79 (1984), S. 249-254 
    Details
    ISSN: 1573-5036
    Keywords: Acid KMnO4 extraction ; Chemical index ; Incubation ; Mineralizable N ; Mineral N ; N uptake ; Soil ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A chemical measure of soil nitrogen (N) availability has been evaluated. The method involved the estimation of initial mineral N, plus mineralizable N released with 0.05N KMnO4 in 1NH2SO4. The results obtained correlated highly significantly with the N uptake by wheat plants (r=0.72,P〈0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182347
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    Microbial populations in trifluralin-treated soil (1984)
    Springer
    Plant and soil 76 (1984), S. 379-387 
    Details
    ISSN: 1573-5036
    Keywords: Actinomycetes ; Bacteria ; Chernozemic soil ; Fungi ; Rhizosphere ; Trifluralin herbicide ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary This study examined the effects of trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine), a soil incorporated herbicide, on soil microflora both in the general soil environment and in the rhizosphere of trifluralin damaged wheat roots. Two Dark Brown Chernozemic soils were treated with various trifluralin rates in the growth chamber and wheat [Triticum aestivum L. ‘Neepawa’] was seeded. Trifluralin generally had no effect on fungi, bacteria, or actinomycete populations in either the general soil or in the rhizosphere. CO2 evolution was unchanged when trifluralin was added to the soil. In wheat plots, at two field locations, there were no significant effects of trifluralin (1.0 kg ha−1) on soil fungi, bacteria, actinomycete, denitrifying bacteria, and nitrifying Nitrobacter propulations. A pure culture study with 42 soil microorganisms showed that many isolates were inhibited at 400 to 100,000 μg g−1 but not at concentrations 〈16 μg g−1. Similar data were obtained from tests on four different soils. These studies indicate that trifluralin is unlikely to cause changes in the numbers of soil microorganisms when used at recommended levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02205595
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    Ecology of the mycophagous nematodeAphelenchus avenae in wheat-field and pine-forest soils (1984)
    Springer
    Plant and soil 78 (1984), S. 417-428 
    Details
    ISSN: 1573-5036
    Keywords: Aphelenchoides spp ; Aphelenchus avenae ; Pinus radiata ; Soil fungi ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The soils of a wheat-field and pine-forest had different mycofloras and supported different populations ofAphelenchus avenae, a mycophagous nematode. The abundance ofA. avenae was correlated with the composition of the mycoflora in these soils; the greater abundance ofA. avenae in wheat-field soil being associated with a more diverse mycoflora.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02450375
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  • 66
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    The behaviour of roots encountering cracks in soil (1984)
    Springer
    Plant and soil 79 (1984), S. 11-28 
    Details
    ISSN: 1573-5036
    Keywords: Beta distribution ; Buckling ; Cracks ; Crack width ; Lateral roots ; Pea ; Penetration ; Penetrometer ; Rape ; Remoulded soil ; Roots ; Safflower ; Seminal axes ; Soil strength ; Undisturbed soil ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary It is shown that probabilities of root penetration across cracks in soil can be calculated effectively using a mathematical model involving root stress and soil distributions and penetrometer/root stress ratios. Penetration criteria are developed, and it is found that the effective penetrometer/root stress ratios take values of about 4 for crack widths smaller than about 2 mm and about 8 for wider cracks. Root swelling does not appear to contribute significantly to the probability of root penetration through any effect on root buckling stress. Suggestions are made for further work on the effects of soil structure and strength on root behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182140
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    Potassium fertilization in relation to plant water potential of wheat (1984)
    Springer
    Nutrient cycling in agroecosystems 5 (1984), S. 285-288 
    Details
    ISSN: 1573-0867
    Keywords: Wheat ; potassium chloride ; irrigation ; plant water potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract ‘The water potential of wheat plants increased during the mid-day noon, probably as an adaptation; the rise was greater with less frequent irrigation and was increased by KCl application.’
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01051627
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    Growth of wheat and subterranean clover on soil artificially compacted at various depths (1984)
    Springer
    Plant and soil 80 (1984), S. 135-138 
    Details
    ISSN: 1573-5036
    Keywords: Hardpans ; Root growth ; Soil compaction ; Subterranean clover ; Wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Wheat crops with stunted chlorotic patches are widespread in northern Victoria, Australia, and are often associated with dense, compacted layers of soil. Poor growth of subterranean clover, with symptoms of cupped and reddened leaflets, is also a problem in these cropping regions during the pasture phase of the rotation. Artificially compacted soils were created to test the hypothesis that these symptoms of poor growth were caused by soil compaction. Soil compacted from 0–20 cm with a bulk density similar to that measured in problem fields reproduced these symptoms in wheat and subterranean clover. Surface compaction alone also reproduced the symptoms in clover.
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    URL: http://dx.doi.org/10.1007/BF02232947
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    Yield response of a common spring wheat cultivar to inoculation withAzospirillum brasilense at various levels of nitrogen fertilization (1984)
    Springer
    Plant and soil 80 (1984), S. 255-259 
    Details
    ISSN: 1573-5036
    Keywords: Azospirillum brasilense ; Wheat ; Triticum aestivum ; N-fertilizer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The yield response of a common spring wheat cultivar,Triticum aestivum, to inoculation withAzospirillum brasilense was studied at four levels of N fertilization. Plant yield increased due to the inoculation treatment only at medium and high levels of N fertilization, with a maximum yield increase of about 8.0 per cent at the highest level (approximately 1.0 g of pure N per plant). Yield increase was mostly due to an increase in the number of grains per spike, and at the highest level of fertilization, also due to a higher number of spikes per plant. At all N levels, the inoculation caused an increase of 0.5–1.4 per cent in the number of fertile spikelets per main spike. Grain protein percentage was unaffected by the inoculation, though significantly increase due to the fertilization treatments. The occurrence of maximum yield response at the highest N level, the response by early-determined yield components, i.e. spikelet number, and the unaffected grain protein content are in accord with the suggestion that the contribution ofAzospirillum brasilense to wheat yield is not through N2-fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02161181
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    Changes in morphometric parameters of the cerebral microcirculation in experimental hypertension (1984)
    Springer
    Bulletin of experimental biology and medicine 98 (1984), S. 1283-1285 
    Details
    ISSN: 1573-8221
    Keywords: cerebral microcirculation ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804324
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