Summary
This paper deals with morphological aspects of early neurogenesis inDrosophila, in particular with the segregation of neuroblasts from the neurogenic region of the ectoderm and the pattern formed by those wells within both the germ band and the procephalic lobe. The neurogenic ectoderm was found to contain neural precursors intermingled with epidermal precursors, extending from the midline up to the primordia of the tracheal tree along the germ band and laterodorsally in the procephalic lobe. Germ band neuroblasts segregate from the neurogenic ectoderm during a period of several hours according to characteristic spatial and temporal patterns. During the first half of the segregation process the pattern of germ band neuroblasts was found to be the same in different animals in both spatial arrangement and number of cells; this permitted the identification of individual neuroblasts from different embryos. Later in development several difficulties were encountered which precluded an exact description of the neuroblast pattern. The constitution of the neurogenic region is discussed in relation to the phenotype of mutants affecting neurogenesis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anderson DT (1972) The development of holometabolous insects. In: Counce SJ, Waddington CH (eds) Developmental Systems: Insect, vol 1. Academic Press, New York, pp 165–241
Bate CM (1976) Embryogenesis of an insect nervous system. I. A map of the thoracic and abdominal neuroblasts inLocusta migratoria. J Embr Exp Morphol 35:107–123
Bate M (1982) Development of the neuroepithelium. Neurosc Res Prog Bull 20 [no 6]:803–806
Bauer V (1904) Zur inneren Metamorphose des Zentralnervensystems der Insekten. Zool Jhb Anat Ontog Tiere 20:123–150
Campos-Ortega JA (1982) Development of the nervous system In: Ransom R (ed) Handbook of Drosophila development. Elsevier, Amsterdam, New York, Oxford, pp 153–181
Campos-Ortega JA (1983) Topological specificity of phenotype expression of neurogenic mutations inDrosophila. Wilhelm Roux's Arch 192:317–326
Campos-Ortega JA, Lehmann R, Jimenez F, Dietrich U (1983) A genetic analysis of early neurogenesis inDrosophila. In Sharma SC (ed) Organizing principles of neural development. Plenum Press, New York [in press]
Haget A (1977) L'embryologie des Insectes. In: Grasse P-P (ed) Traite de zoologie, vol VIII Fs. V-B Masson, Paris, pp 1–387
Jimenez F, Campos-Ortega JA (1982) Maternal effects of zygotic mutations affecting early neurogenesis inDrosophila. Wilhelm Roux's Arch 191:191–201
Lehmann R, Jimenez F, Dietrich U, Campos-Ortega JA (1983) On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster. Wilhelm Roux's Arch 192:62–74
Lohs-Schardin M, Cremer CH, Nüsslein-Volhard Chr (1979) A fate map for the larval epidermis ofDrosophila melanogaster: Localized defects following irradiation of the blastoderm with an ultraviolet laser microbeam. Dev Biol 73:239–255
Malzacher P (1968) Die Embryogenese des Gehirns paurometaboler Insekten. Untersuchungen anCarausius morosus undPeriplaneta americana. Z Morphol Ökol Tiere 62:103–161
Nordlander RH, Edwards JS (1969) Postembryonic brain development in the monarch butterfly,Danaus plexippus plexippus, L. I. Cellular events during brain morphogenesis. Wilhelm Roux's Arch 162:197–217
Poulson DF (1937) Chromosomal deficiencies and the embryonic development ofDrosophila melanogaster. Proc Natl Acad Sci 23:133–137
Poulson DF (1950) Histogenesis, organogenesis and differentiation in the embryo ofDrosophila melanogaster Meigen. In: Demerec M (ed) Biology of Drosophila. Wiley, New York, pp 168–274
Sander K (1956) The early embryology ofPyrilla perpusilla Walker (Homoptera), including some observations on the later development. Aligarh Musl Univ Publ 4:1–61
Sonnenblick BP (1950) The early embryology ofDrosophila melanogaster. In: Demerec M (ed) Biology of Drosophila, Wiley, New York, pp 62–167
Turner FR, Mahowald AP (1977) Scanning electron microscopy ofDrosophila melanogaster embryogenesis. II. Gastrulation and segmentation. Dev Biol 57:403–416
Turner FR, Mahowald AP (1979) Scanning electron microscopy ofDrosophila melanogaster embryogenesis. III. Formation of the head and caudal segments. Dev Biol 68:96–109
Underwood EM, Turner FR, Mahowald AP (1980) Analysis of cell movements and fate mapping during early embryogenesis inDrosophila melanogaster. Dev Biol 74:286–301
Wheeler WM (1891) Neuroblasts in the arthropod's embryo. J Morphol 4:337–343
Wright TRF (1970) The genetics of embryogenesis inDrosophila. Adv Genetics 15:262–395
Zalokar M, Erk I (1976) Division and migration of nuclei during early embryogenesis ofDrosophila melanogaster. J Micr Biol Cell 25:97–106
Zalokar M, Erk I (1976) Phase-partition fixation and staining ofDrosophila eggs. Stain Technol 52:89–95
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hartenstein, V., Campos-Ortega, J.A. Early neurogenesis in wild-typeDrosophila melanogaster . Wilhelm Roux' Archiv 193, 308–325 (1984). https://doi.org/10.1007/BF00848159
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00848159