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  • General Chemistry  (3,442)
  • Cell & Developmental Biology  (1,795)
  • Animals  (1,113)
  • Fisheries
  • ddc:553.21
  • 2020-2023  (41)
  • 1995-1999  (6,355)
  • 1985-1989
  • 1945-1949
  • 2021  (41)
  • 1996  (2,838)
  • 1995  (3,517)
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  • 1
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    Impressum – Inhalt – Vorworte – Totenseite (2021)
    Details
    Publication Date: 2022-03-16
    Description: Hier finden sie das Impressum, Inhaltsverszeichnis, Vorwort des Vorsitzenden, Vorwort der Schriftleitung, sowie die Totenseite (Georg Ramm) der TELMA, Band 51 (2021).
    Description: DFG, SUB Göttingen, DGMT
    Description: editorial
    Keywords: ddc:553.21
    Language: German
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  • 2
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    Effects of water management on peatland water table and peatland subsidence (2021)
    Details
    Publication Date: 2022-03-17
    Description: Drained peatlands are hotspots for carbon dioxide (CO2) and nitrous oxide (N2O) emissions. In Niedersachsen, 69 % of the peatland area is used for agriculture and is responsible for 11 % of the annual CO2 and N2O emissions. Raising peatland water tables to 0.30 m below surface could reduce emissions. In this study, three water regulation methods were tested to raise water table and to maintain grassland use on bog peatlands. In the first method, weirs were installed to block ditches and retain surface runoff within the blocking ditches. For the second method, ditch impoundment, additional water was pumped into the ditches creating constant ditch water levels. The third method, subsurface irrigation, further increased the water table within the grassland by allowing water to flow from the ditch into the bog area via subsurface pipes. Ditch impoundment and subsurface irrigation methods effectively raised the bog water tables. In the summer 2020, the mean water tables for ditch impoundment and subsurface irrigation reached 0.32 m and 0.23 m below surface, while the water table with blocking ditches was much lower with 0.61 m below surface. Overall, the subsurface irrigation method successfully raised the bog water tables and reduced subsidence. Negative aspects of this method are the costs for pipes and weirs, the reduced trafficability and the increased water demand.
    Description: Entwässerte Moore sind Hotspots für die Emission von Kohlendioxid (CO2) und Lachgas (N2O). In Niedersachsen werden 69 % der Moorflächen landwirtschaftlich genutzt und sind für 11 % der jährlichen CO2- und N2O-Emissionen verantwortlich. Eine Anhebung des Moorwasserstandes auf 0.30 m unter Geländeoberkante (GOK) könnte die Emissionen verringern. In dieser Studie wurden drei Methoden zur Wasserregulierung getestet, um Moorwasserstände anzuheben und die Grünlandnutzung in einem Hochmoor aufrechtzuerhalten. Für den Grabenanstau wurden Wehre installiert, um Gräben zu blockieren und den Oberflächenabfluss zurückzuhalten. Beim Grabeneinstau wird ein konstanter Wasserspiegel in den Gräben durch zugepumptes Wasser generiert. Bei der Unterflurbewässerung wird der Moorwasserstand weiter erhöht, in dem Wasser aus dem Graben über unterirdische Rohre in die Fläche geleitet wird. Mit dem Grabeneinstau und der Unterflurbewässerung konnten die Moorwasserstände erhöht werden. Im Sommer 2020 erreichten die mittleren Moorwasserstände beim Grabeneinstau und der Unterflurbewässerung 0.32 m und 0.23 m unter GOK, während der Moorwasserstand beim Grabenanstau mit 0.61 m unter GOK deutlich niedriger lag. Insgesamt konnten mit der Unterflurbewässerung Moorwasserstände erfolgreich angehoben und die Höhensackung der Mooroberfläche verringert werden. Negative Aspekte dieser Methode sind die Kosten für Rohre und Wehre sowie die Pumpe, die eingeschränkte Befahrbarkeit und ein erhöhter Wasserbedarf.
    Description: DFG, SUB Göttingen
    Description: research
    Keywords: ddc:553.21
    Language: English
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  • 3
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    80 Jahre Michael Succow – ein Leben für den Natur- und Moorschutz: Interview mit vier seiner Schülerinnen und Weggefährtinnen (2021)
    Details
    Publication Date: 2022-03-17
    Description: Laudatio anlässlich Michael Succows achtzigstem Lebensjahr.
    Description: DFG, SUB Göttingen, DGMT
    Description: editorial
    Keywords: ddc:553.21
    Language: German
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  • 4
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    Faktencheck – Was bedeutet die Vorgabe der Deutschen Moorschutzstrategie „Einsparung von Emissionen in Höhe von 5 Millionen t CO2 Äquivalenten pro Jahr aus Moorböden in Deutschland bis 2030“ in der praktischen Umsetzung? (2021)
    Details
    Publication Date: 2022-03-17
    Description: In Deutschland sind 92 % der Moore entwässert. Diese Flächen verursachen jedes Jahr etwa 53 Millionen Tonnen CO2-Äquivalente, was 6,7 % der gesamten Treibhausgasemissionen in Deutschland entspricht. Der überwiegende Teil (83 %) dieser Emissionen aus Moorböden resultiert aus landwirtschaftlichen Flächen. Ziel der 2021 veröffentlichten Nationalen Moorschutzstrategie ist es, die jährlichen Treibhausgasemissionen aus Moorböden bis 2030 um mindestens 5 Millionen Tonnen CO2-Äquivalente zu reduzieren. Um die Treibhausgas-Reduktionsziele zu erreichen, müssten in Deutschland, je nach Maßnahmen und Moortyp, rund 150.000 ha Moorflächen bis 2030 vernässt werden. Angesichts der langwierigen Prozesse der Projektentwicklung, der Genehmigungsverfahren und der technischen Umsetzung müsste aber umgehend und umfassend mit der Realisation begonnen werden. Dieses Ziel ist aufgrund der Freiwilligkeit der Maßnahmen derzeit nicht ansatzweise realistisch und erfordert massive, vor allem finanzielle Maßnahmen.
    Description: In Germany, 92 % of all peatlands are drained. These areas are responsible for approximately 53 million metric tons of CO2 equivalents each year, or 6.7 % of the total greenhouse gas emissions in Germany. The majority (83 %) of these emissions from peatlands result from agricultural used peatlands. The goal of the National Peatland Protection Strategy, published in 2021, is to reduce annual greenhouse gas emissions from peatland soils by at least 5 million metric tons of CO2 equivalents by 2030. To achieve the greenhouse gas reduction targets, around 150,000 hectares of peatland would need to be rewetted in Germany by 2030, depending on the rewetting technique and peatland type. However, in view of the long processes of project development, approval procedures and technical implementation, realization would have to begin immediately and comprehensively. Due to the voluntary nature of rewetting measures, this goal is not remotely realistic at present and requires massive measures, especially adequate funding.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21
    Language: German
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  • 5
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    Gültigkeit des Darcy-Gesetzes bei Kapillarhub in feinporigen Torfmatrices (2021)
    Details
    Publication Date: 2022-03-17
    Description: In engen Poren ist der Fallenergie der Kapillarhub entgegengesetzt, was im Fallgesetz und im darcy-/hagen-poiseuilleschen Strömungsgesetz berücksichtigt werden muss.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21
    Language: German
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  • 6
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    Sphagnumfarm Barver: Planung und Einrichtung einer Torfmooskultur auf Hochmoorgrünland – erste Erfahrungen (2021)
    Details
    Publication Date: 2022-03-17
    Description: Der Torfeinsatz in den Erden und Substraten des Gartenbaus ist mit CO2-Emissionen verbunden und eine Reduzierung durch den Ersatz mit nachwachsenden Rohstoffen daher spätestens seit der Klimaübereinkunft Paris 2015 eine gesellschaftliche Herausforderung. Torfmoose (Sphagnum spp.) stellen dabei einen der wenigen Ersatzstoffe dar, die die hohen qualitativen Anforderungen an Kultursubstrate erfüllen können. Mit der Einrichtung des Sphagnum farming Projektes „Barver“, Landkreis Diepholz, soll von 2018 bis 2021 die Torfmooskultivierung auf Hochmoorgrünland in der Praxis getestet werden. Voraussetzung zur Anlagenplanung war eine detaillierte Grundlagenerhebung des inhomogenen Torfkörpers, auf deren Basis der Oberbodenabtrag der Betriebsfläche (1 ha) und die Einrichtung des Bewässerungssystems erfolgte. Die Kulturfläche wurde abschließend manuell mit Torfmoosfragmenten von unterschiedlichen Spenderflächen beimpft. Für die erforderliche Polderbewässerung musste ein Kompromiss aus gering überstauten Schwarztorfflächen und flurnah bewässertem Weisstorfbereich akzeptiert werden. Schnell und flächig einsetzendes Wachstum der Torfmoosfragmente signalisiert, dass regionales Sphagnum farming auf degradiertem, drainierten Hochmoorgrünland bei funktionierender Wasserversorgung möglich ist. Die jetzt folgende Projektphase dient der Ermittlung der optimalen Bestandsentwicklung. Daneben sind technische und rahmenpolitische Fragen bis zu einer wirtschaftlich tragfähigen landwirtschaftlichen Torfmooskultivierung zu klären.
    Description: The use of peat in growing media for horticulture is associated with CO2 emissions and a reduction through replacement with renewable raw materials has therefore been a social challenge since Paris Agreement 2015 at the latest. Peat mosses are one of the few substitutes that can meet the high quality requirements for growing media. With the establishment of the Sphagnum farming project “Barver”, Diepholz district (Niedersachsen, Germany), peat moss cultivation on raised bog grassland is to be tested in practice from 2018 to 2021. A fundamental prerequisite of planning of the one hectare study site was an in-depth basic evaluation of its inhomogeneous peat body, being the base of site preparation and irrigation system. Finally, the study site was inoculated manually with fragmented peat mosses of different origins. The necessary watering of the polder had to be a trade-off between flood irrigation of a black peat area and subirrigation of the adjacent white peat zone. Rapidly and widespread growth of peat mosses indicate, that the regional cultivation of Sphagnum on degraded and drained bog grassland with a working irrigation system is feasible. The now starting phase is aiming on an optimal developed Sphagnum stock. Aside, there are technical challenges and administrative obstacles to be overcome before cultivation of peat mosses will give economically viable agricultural crops.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21
    Language: German
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  • 7
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    „Moor muss nass“ – die Botschaft des Hans Joosten (2021)
    Details
    Publication Date: 2022-03-17
    Description: Laudatio anlässlich der Verleihung des Deutschen Umweltpreises der Deutschen Bundesstiftung Umwelt (DBU) an Hans Joosten.
    Description: DFG, SUB Göttingen, DGMT
    Description: editorial
    Keywords: ddc:553.21
    Language: German
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  • 8
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    Zu Verbreitung und Standort von Scheuchzeria palustris L. (Blasenbinse) in Nordostdeutschland (2021)
    Details
    Publication Date: 2022-03-17
    Description: Die Untersuchungen zu Verbreitung und Standort der Blasenbinse (Scheuchzeria palustris) in Nordostdeutschland werden vorgestellt. In den Jahren 2000 bis 2005 sowie 2020 wurden 29 Moore (27 in Mecklenburg-Vorpommern, 2 in Brandenburg) mit nach 1950 gemeldeten Funden der Art untersucht. Einzugsgebiet, Moorfläche, Mooraufbau, hydrogenetischer Moortyp, Flora und Vegetation sowie Hydrologie der untersuchten Niedermoore werden präsentiert. Die Ursachen für den Rückgang der Vorkommen werden diskutiert. Die Untersuchungen haben ergeben, dass dem Wasserfaktor für die Erhaltung der Blasenbinsen-Vorkommen eine entscheidende Rolle zukommt. Wasserstandschwankungen müssen in Bezug zur Mooroberfläche mit 1 bis 2 dm sehr gering bleiben. Durch die Fähigkeit zur Oszillation der Mooroberfläche kann ein Überstau weitgehend vermieden werden. Voraussetzung hierfür ist ein mächtiger Moorkörper mit oberflächennah anstehenden wässrigen Torfmoos-Torfen.
    Description: In this paper studies on the distribution and habitat of Scheuchzeria palustris in Northeastern Germany are presented. Twenty-nine fens (27 in Mecklenburg-Vorpommern, 2 in Brandenburg) were surveyed between 2000 and 2005 and additionally in 2020. The surveyed sites were all sites where this species had been observed since 1950. The catchment area, fen area, stratigraphy, hydrogenetic mire types, flora and vegetation as well as the hydrology for each site are shown. The reasons for the decline in populations are discussed. This study shows that hydrology plays a decisive role in maintaining Scheuchzeria palustris populations. The water level should be stable in relation to the peat surface with fluctuations no larger than 1 to 2 dm. Due to the shrinking and swelling capacity of peat, flooding can be largely avoided. The prerequisite for this is a thick peat body with Sphagnum peat at the surface.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21
    Language: German
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  • 9
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    Das Flächennaturdenkmal Rahmannsmoor bei Krakow am See (Mecklenburg-Vorpommern) – Genese und Insektenwelt (Lepidoptera, Ephemeroptera, Trichoptera) (2021)
    Details
    Publication Date: 2022-03-17
    Description: In den Jahren 2017 bis 2019 wurde das Flächennaturdenkmal „Rahmannsmoor“ in Krakow am See bezüglich der Lepidopteren, Ephemeropteren und Trichopteren untersucht. Parallel dazu sind moorstratigraphische Untersuchungen vorgenommen worden. Das in einer kuppigen Endmoränenlandschaft liegende Kesselmoor hat eine Moormächtigkeit von mehr als 5 Metern und ist über einem sandigen Untergrund aufgewachsen. Es befindet sich auf Grund einer längeren Trockenperiode in einer Phase der Stagnation, wobei mächtige, gering zersetzte Torfmoos-Torfe die Voraussetzungen für ein erneutes Moorwachstum geben. Vegetationskundlich wird das Rahmannsmoor von Torfmoosen, Wollgräsern, Moosbeeren und Rosmarinheiden geprägt. Es konnten 100 Taxa an Nachtfaltern, 13 Köcherfliegenarten und eine Eintagsfliegenart nachgewiesen werden. Tyrphobionte/-phile Faunenelemente sind bei den untersuchten Gruppen eher selten, wobei die „Restbiozönose“ noch zahlreiche eurytopere Arten der Moore beinhaltet. Das Moor soll entkusselt werden, um die baumfreien Flächen zu erweitern und die Verdunstung zu senken.
    Description: From 2017 to 2019, the natural monument “Rahmannsmoor” in Krakow am See was surveyed for lepidopterans, ephemeropterans and trichopterans. At the same time the stratigraphy was investigated. The kettle-hole mire, located in a dome-shaped end moraine landscape, is more than five meters deep and has a sandy subsoil. Peat growth is stagnated during dry years. Thick, slightly decomposed peat is a good prerequisite for renewed bog growth. In terms of vegetation, the Rahmannsmoor is characterised by Sphagnum mosses, cotton grasses, bog bilberry and rosemary heath. One hundred taxa of moths, 13 species of Trichoptera and one species of Ephemeroptera were recorded. Tyrphobiont and tyrphophilous faunal elements are rather rare in the studied groups, whereas the “residual biocoenosis” still contains numerous eurytope species of the mires. The shrubs will be removed from the peatland in order to enlarge the open areas and to reduce evaporation.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21
    Language: German
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  • 10
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    Hinweise auf Bücher zum Thema „Moor und Torf“ (2021)
    Details
    Publication Date: 2022-03-17
    Description: Axel Precker: MacFarlane, R. (2015): Karte der Wildnis. 303 S., 15 Abbildungen, Reihe Naturkunden No. 18, Hrsg. J. Schalansky, Verlag Matthes & Seitz, Berlin, ISBN 978-95757-101-4. Andreas Bauerochse: Oman, H. & Hofer, W. (Hrsg., 2021): Der Moor-Effekt – Gesund und schön mit der natürlichen Kraft des „schwarzen Goldes“ 120 S., zahlreiche Abb. Literaturverzeichnis; kartonierter Einband, Unteraichwald, Ampuls-Verlag. ISBN 978-3-9519818-2-6.
    Description: DFG, SUB Göttingen, DGMT
    Description: bibliography
    Keywords: ddc:553.21
    Language: German
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  • 11
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    Veröffentlichungen aus dem deutschen Sprachraum zum Thema „Moor und Torf“ aus den Jahren 2020 und 2021 mit Nachträgen für frühere Jahre (2021)
    Details
    Publication Date: 2022-03-17
    Description: DFG, SUB Göttingen, DGMT
    Description: bibliography
    Keywords: ddc:553.21
    Language: German
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  • 12
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    Wiederherstellung von Waldmooren im Fauna-Flora-Habitat-Gebiet „Moorwaldgebiet Großdittmannsdorf“ – eine Bilanzierung der forstlichen Lehrausbildung 2018 bis 2021 (2021)
    Details
    Publication Date: 2022-03-17
    Description: Die Lehrausbildung zum Forstwirt im Fachbereich „Naturschutz/Landschaftspflege“ war 2018 bis 2021 auf die Umsetzung der Moorrevitalisierung im Fauna-Flora-Habitat-Gebiet „Moorwaldgebiet Großdittmannsdorf“ gerichtet. Erreicht wurde eine lokale Verbesserung des Waldinnenklimas (Luftfeuchtigkeit, Kühlung), der Grundwasserneubildung und Stabilisierung des Bodenwasserhaushaltes mit vorteilhaften Wirkungen auf die biologische Vielfalt (Feuchtbiotope, Moorbiozönose).
    Description: From 2018 to 2021, the apprenticeship training for foresters in the field of “nature conservation/landscape management” was focused on the implementation of measures for peatland revitalisation in the Habitats Directive Site “Moorwaldgebiet Großdittmannsdorf ”. A local improvement of the internal forest climate (humidity, cooling), groundwater recharge and stabilisation of the soil water balance with beneficial effects on biodiversity (wetland biotopes, bog biocoenosis) was achieved.
    Description: DFG, SUB Göttingen, DGMT
    Description: report
    Keywords: ddc:553.21 ; ddc:333.72
    Language: German
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  • 13
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    Klimaschutz durch Moorbodenschutz in Bayern: Warum es mit der Moorrenaturierung nicht vorangeht und wie sich das ändern lässt (2021)
    Details
    Publication Date: 2022-03-17
    Description: Entlang der Donau zwischen Ulm und Ingolstadt liegen verschiedene Flusstal-Niedermoore, die sich während und nach der letzten Eiszeit entwickelt haben. Nahezu alle Moorböden sind in den vergangenen 200 Jahren entwässert und immer intensiver genutzt worden, weshalb fortwährend erhebliche Mengen an Klimagasen entweichen. Am Beispiel von acht Niedermoorrenaturierungen werden aus 30-jähriger Erfahrung die unterschiedlichen Hemmnisse und Lösungsansätze dargestellt. Daraus gewonnene Erkenntnisse könnten auch für andere Regionen nützlich sein. Es wird aufgezeigt, wie klimawirksamer Moorschutz rascher und effektiver gelingen kann, und welche Voraussetzungen dafür geschaffen werden müssen. Dass man beim Klimaschutz auch durch Moorbodenschutz schneller zu Ergebnissen kommen muss, zeigt die 26. Weltklimakonferenz 2021 (COP26) in Glasgow.
    Description: Along the Danube between Ulm and Ingolstadt, various river valley fens developed after the last ice age. Almost all peatlands have been drained over the past 200 years and intensively used resulting in significant greenhouse gase emissions. Due to the example of eight peatland restoration projects, obstacles and solutions are presented from over 30 years of experience that could be useful for other regions. Conclusions are drawn as to how peatlands can be protected more quickly and effectively to lower greenhouse gas emissions. Additionally, the conditions that need to be created for peatland protection are identified. The 26th United Nations Climate Change Conference (COP26) in Glasgow demonstrated the need to achieve quick results in climate protection through peatland protection to avoiding further global warming.
    Description: DFG, SUB Göttingen, DGMT
    Description: research
    Keywords: ddc:553.21 ; ddc:333.72
    Language: German
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  • 14
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    Equitable allocations in northern fisheries: bridging the divide for Labrador Inuit (2021)
    Frontiers Media
    Details
    Publication Date: 2022-10-26
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kourantidou, M., Hoagland, P., Dale, A., & Bailey, M. Equitable allocations in northern fisheries: bridging the divide for Labrador Inuit. Frontiers in Marine Science, 8, (2021): 590213, https://doi.org/10.3389/fmars.2021.590213.
    Description: Canada has undertaken commitments to recognize the rights of Indigenous Peoples in fisheries through policies and agreements, including Integrated Fishery Management Plans, the Reconciliation Strategy, and Land Claim Agreements (LCAs). In addition to recognizing rights, these commitments were intended to respect geographic adjacency principles, to enhance the economic viability of Indigenous communities, and to be reflective of community dependence on marine resources. We examined the determinants of quota allocations in commercial fisheries involving Nunatsiavut, Northern Labrador, the first self-governing region for the Inuit peoples in Canada. It has been argued that current fishery allocations for Nunatsiavut Inuit have not satisfied federal commitments to recognize Indigenous rights. Indicators that measure equity in commercial allocations for the turbot or Greenland halibut (Reinhardtius hippoglossoides) and northern shrimp (Pandalus borealis) fisheries were identified and assessed. In these two cases, historical allocations continue to predominate for allocations based upon equity or other social or economic considerations. We illustrate equity-enhancing changes in the quota distribution under scenarios of different levels of inequality aversion, and we make qualitative assessments of the effects of these allocations to Nunatsiavut for socioeconomic welfare. This approach could benefit fisheries governance in Northern Labrador, where federal commitments to equity objectives continue to be endorsed but have not yet been integrated fully into quota allocations.
    Description: This research was undertaken with funding from the Canada First Research Excellence Fund through the Ocean Frontier Institute (MK and MB) and the Johnson Endowment of the Woods Hole Oceanographic Institution’s (WHOI) Marine Policy Center (PH).
    Keywords: Fisheries ; Allocations ; Equity ; Indigenous rights ; Access
    Repository Name: Woods Hole Open Access Server
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  • 15
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    Experiments on the induced spawning and larval rearing of the milkfish, Chanos chanos (Forsskal) in 1979 (2021)
    In:  aqdchief@seafdec.org.ph | http://aquaticcommons.org/id/eprint/18569 | 2002 | 2015-11-15 16:06:30 | 18569 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Description: This paper summarizes the results of the experiments on the induced breeding and larval rearing of milkfish (Chanos chanos) during the 1979 season. Milkfish larvae could be reared successfully without the use of trochophore larvae of oysters as feed during the first few days. In order to induce the ovulation of wild adult milkfish a higher dose of human chorionic gonadotropin hormone is required.
    Keywords: Fisheries ; Chanos chanos ; ISEW ; Philippines ; marine environment ; Brood stocks ; Fish culture ; Fish larvae ; Food organisms ; Induced breeding ; Larval development ; Sex hormones
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
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  • 16
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    Knowing Asian aquaculture and fisheries. Part 1 (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20100 | 17342 | 2016-02-24 22:18:26 | 20100 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Description: An outline is given of aquaculture and fisheries in Asia, providing information of use to students whose work can influence laws, rules, policy and regulations on aquaculture and fisheries, with the view in mind to sustainable aquaculture. In this issue, the following countries are examined: China, Indonesia, and Bangladesh.
    Keywords: Aquaculture ; Fisheries ; Fishery management ; Aquaculture development ; Aquaculture regulations ; Marine aquaculture ; Freshwater aquaculture ; Fishery industry ; Asia ; Bangladesh ; China
    Repository Name: AquaDocs
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    Format: application/pdf
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  • 17
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    Knowing Asian aquaculture and fisheries. Part 4 (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20067 | 2002 | 2016-03-04 15:16:24 | 20067 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Vietnam ; Sri Lanka ; Sri Lanka ; Vietnam ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture techniques ; Brackishwater aquaculture ; Feed ; Fish culture ; Fish diseases ; Fisheries ; Fishery data ; Food organisms ; Freshwater aquaculture ; Marine aquaculture ; Marine fisheries ; Mollusc culture ; Pond culture ; Seaweed culture ; Shrimp culture
    Repository Name: AquaDocs
    Type: article
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    Format: pp.9-10, 27
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  • 18
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    Knowing Asian aquaculture and fisheries (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20055 | 2002 | 2016-03-03 11:33:32 | 20055 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Asia ; Cambodia ; India ; Asia ; Cambodia ; India ; Myanmar ; Myanmar ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture development ; Aquaculture economics ; Aquaculture techniques ; Brackishwater aquaculture ; Catching methods ; Culture effects ; Environmental impact ; Fish culture ; Fisheries ; Fishery development ; Fishery resources ; Fishery statistics ; Freshwater aquaculture ; Marine aquaculture ; Shrimp culture ; Sustainability ; Trade
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: pp.9-10, 29
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  • 19
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    Regional survey of heavy metals in fish and fish products: Indonesia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26291 | 23782 | 2019-04-08 09:42:05 | 26291 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Pollution ; Indonesia ; Heavy metals ; Chemical pollution ; Pollution monitoring
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 10-19
    Format: 10
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  • 20
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    Regional survey of heavy metals in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26293 | 23782 | 2019-03-22 03:49:21 | 26293 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Heavy metals ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 38-46
    Format: 9
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  • 21
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    Round scad exploration by purse seine in the South China Sea, Area III: Western Philippines (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26259 | 2002 | 2019-03-01 05:56:06 | 26259 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: Round scad exploration by purse seine in the waters of western Philippines was conducted from April 22 to May 7, 1998 for a period of five (5) fishing days with a total catch of 7.3 tons and an average of 1.5 tons per setting. Dominant species caught were Decapterus spp. having 70.09% of the total catch, followed by Selar spp. at 12.66% and Rastrelliger spp. 10.70%. Among the Decapterus spp. caught, D. macrosoma attained the highest total catch composition by species having 68.81% followed by D. kurroides and D.russelli with 0.31% and 1.14% respectively. The round scad fishery stock was composed mainly of juvenile fish (less than 13 cm) and Age group II (13 cm to 14 cm). Few large round scad at Age group IV and V (20 cm to 28 cm) stayed at the fishery. Other fishes caught were: Auxis rochei (0.85%), A. thazard (0.12%), Caranx spp. (0.45%), Emmilichthys nitidus (0.58%), Euthynnus affinis (0.42%), Leiognathus ruconius (0.58%), Loligo sp. (0.31%), Megalaspis cordyla (0.09%), Rastrelliger spp. (10.70%), Sardinella longiceps (0.03%), Scomberoides lysan (0.24%), Selar spp. (12.66%), Sphyraena spp. (0.90%), Thunnus albacares (0.96%) and others (1.02%). Tuna and tuna like fishes such as yellowfin tuna, eastern little tuna, bullet tuna, frigate tuna and oceanic squid are distributed in the upper latitudes of the survey area. On the other hand, round scads, big-eyed scads and Indian mackerels are dominantly present in the lower latitudes of the survey area.
    Keywords: Fisheries ; Exploratory fishing ; Purse seining ; Age composition ; Catch composition ; Fishery surveys ; Carangid fisheries ; South China Sea ; Philippines ; Rastrelliger ; Decapterus
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 49-64
    Format: 16
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  • 22
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    Fisheries in Brunei Darussalam (2021)
    Training Department, Southeast Asian Fisheries Development Center | Samut Prakarn, Thailand
    In:  http://aquaticcommons.org/id/eprint/26215 | 17342 | 2019-02-08 06:25:54 | 26215 | Southeast Asian Fisheries Development Center, Training Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in this paper is the status of the fishery industry in Brunei Darussalam. Specifically, it discussed the following topics: fishery management strategies, zonation scheme, licencing, the use of poisons and explosives, the minimum cod-end mesh size for trawlers, closed areas, enhancement of fishing grounds, and the enforcement activities.
    Keywords: Fisheries ; Fishery resources ; Fishery management ; Fisheries ; Ecological zonation ; Licensing ; Fish poisoning ; Catching methods ; Illegal fishing ; Explosive fishing ; Fishing gear ; Season regulations ; Fishing grounds
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 34-40
    Format: 7
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  • 23
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    Regional survey of heavy metals in fish and fish products: Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26295 | 23782 | 2019-03-22 08:39:12 | 26295 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Thailand ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 53-58
    Format: 6
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  • 24
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    Regional survey of heavy metals in fish and fish products: Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26292 | 23782 | 2019-03-22 03:43:09 | 26292 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Malaysia ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 20-37
    Format: 18
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  • 25
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    Tuna resource exploration with longline in the South China Sea, Area III: Western Philippines (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26258 | 2002 | 2019-03-01 06:00:19 | 26258 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: An exploratory tuna longline fishing survey was conducted using the research and training vessels of the Southeast Asian Fisheries Development Center, the 1,178 GT MV SEAFDEC and the Bureau of Fisheries and Aquatic Resources, the 165 GT MV MAYA-MAYA in the South China Sea Waters, West of the Philippines from April to May, 1998. A total of 3,796 hooks was set in sixteen (16) fishing stations. There were no tuna caught during the entire survey but only minor and irrelevant species like the Pacific lancetfish, sharks and an opah species, Lampris guttatus. The important fishing and oceanographic factors during the survey and other research results on longline are described and analyzed. Additional longline studies within and near the Philippines territorial waters are also presented to substantiate the research results of the joint SEAFDEC/BFAR resource exploratory.
    Keywords: Fisheries ; Exploratory fishing ; Catch composition ; Fishery surveys ; Longlining ; Tuna fisheries ; South China Sea ; Philippines
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 39-48
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  • 26
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    Regional survey of pesticide residues in fish and fish products: Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26299 | 23782 | 2019-03-27 06:00:01 | 26299 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Malaysia ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Biochemical analysis ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 71-74
    Format: 4
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  • 27
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    Regional survey of pesticide residues in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26300 | 23782 | 2019-03-27 05:58:36 | 26300 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Aquaculture ; Chemistry ; Fisheries ; Myanmar ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 75-83
    Format: 9
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  • 28
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    Regional survey of histamine in fish and fish products: Indonesia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26307 | 23782 | 2019-03-27 03:35:56 | 26307 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Indonesia ; Histamines ; Biological sampling ; Fish ; Fishery products ; Quality control
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 116-123
    Format: 8
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  • 29
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    Regional survey of pesticide residues in fish and fish products: Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26303 | 23782 | 2019-03-27 05:51:15 | 26303 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Thailand ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Dried products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 100-105
    Format: 6
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  • 30
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    Regional survey of histamine in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26309 | 23782 | 2019-03-27 03:49:31 | 26309 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Histamines ; Biological sampling ; Biochemical analysis ; Fish ; Fishery products
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 129-133
    Format: 5
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  • 31
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    Determination of chemical properties of meat: Determination of K value (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26826 | 23782 | 2019-11-21 00:56:12 | 26826 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the determination of K value which is an index to measure the enzymatic freshness of fish and squid. Specifically, reagents, apparatus and the analytical procedures needed and the calculations are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-6.1-B-6.7
    Format: 7
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  • 32
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    Determination of chemical properties of meat: Freshness testing paper (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26825 | 23782 | 2019-11-21 00:52:35 | 26825 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in measuring K value in fish meat by means of the freshness testing paper technique.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-7.1-B-7.2
    Format: 2
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  • 33
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    Determination of physical properties of meat: Measurement of pH (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26802 | 23782 | 2019-11-12 05:28:20 | 26802 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the measurement of pH in the fresh fish meat. Specifically, the procedures in sampling and sample preparation, apparatus and reagents required, and the analytical procedures are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Microbiological analysis ; Fishery products ; Processed fishery products ; Fish inspection ; Fishery industry ; Food additives ; Food technology ; Standards ; Specifications ; pH
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: A-3.1-A-3.2
    Format: 2
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  • 34
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    Analysis of additives: Determination of starch (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26842 | 23782 | 2019-11-15 07:54:48 | 26842 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Starch is commonly used in the production of fish jelly products as an extender and as binding agent. The paper provides the methodology in the determination of starch in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the starch in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Starch ; Additives ; Food additives
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: D-4.1-D-4.4
    Format: 4
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  • 35
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    Red tides and paralytic shellfish poisoning in the Philippines (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26881 | 23782 | 2019-11-05 02:46:02 | 26881 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Monitoring and investigative work undertaken in the Philippines regarding dinoflagellate blooms are described. Chronological observations of the occurrence of red tides, aerial surveys, spatial distribution of the dinoflagellate and the physical environment are discussed. Fishing and the examination of gut content of fish and mussels and bioassay tests are detailed. Incidents of paralytic shellfish poisoning in the Philippines are considered briefly.
    Keywords: Fisheries ; Health ; Environmental monitoring ; Red tides ; Public health ; Medicine ; Dangerous organisms ; Philippines
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 52-79
    Format: 28
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  • 36
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    Red tide and paralytic shellfish poisoning phenomena in Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26885 | 23782 | 2019-11-05 02:23:34 | 26885 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: A report is made of the first incidence occurring of paralytic shellfish poisoning in Thailand in May 1983, following an extensive bloom of Trichodesmium erythraeum. Investigations undertaken regarding the source of the toxicity are outlined.
    Keywords: Fisheries ; Health ; Biological poisons ; Public health ; Red tides ; Shellfish ; Dangerous organisms ; Thailand
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 90-91
    Format: 2
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  • 37
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    Red tide and paralytic shellfish poisoning in Sabah, Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26879 | 23782 | 2019-11-05 02:54:38 | 26879 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: A brief account is given of recent cases of paralytic shellfish poisoning in Sabah, Malaysia, and toxicological studies undertaken. Hydrography surveys, underwater observations after the occurrence of the red tides and plankton studies and monitoring of red tides are discussed.
    Keywords: Fisheries ; Health ; Shellfish ; Toxicity tests ; Red tides ; Public health ; Dangerous organisms ; Malaysia
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 35-42
    Format: 8
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  • 38
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    Microbiological procedure: Vibrio cholera (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26852 | 23782 | 2019-11-15 07:36:44 | 26852 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Cholera is an acute specific infection caused by the organism, Vibrio cholera. Diagnosis may be confirmed by the presence of large numbers of the comma-shaped bacilli on direct microscopic examination of a fecal or vomitus smear, and by the isolation of the organism on culture. Fish and shellfish have been identified as vehicles of cholera. Large numbers of V. cholera must usually be ingested to cause cholera. Thus problems often occur when poor handling and inadequate refrigeration have allowed the organism to multiply. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio cholerae
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: E-7.1-E-7.5
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  • 39
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    Fisheries statistics in Brunei Darussalam (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26890 | 23782 | 2019-11-14 01:01:29 | 26890 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: Fishery statistics in Brunei Darussalam have been collected by the Department of Fisheries since the 1940s. In the early 1980s, a number of statistics were collected, such as catch and effort data of artisanal fishermen, aquaculture statistics, processing statistics as well as data from major wet markets focusing on the amount, prices of marketed fish either from the local fishermen or imported. In 1984, the collection of statistics on commercial fishing was started. The statistics have been used in the formulation of fishery management and development policies as well as for sectoral development. Following a brief account of the responsibility and statistic collections of the Department of Fisheries, an examination is made of employment in the fishery sector, fisheries production, fish marketed and the GDP for the fishery industry. Fisheries in Brunei Darussalam is a very healthy industry, where production is well below the maximum allowable harvestable limit of 20,000 tons at 30%. The Department is embarking to increase production from the capture fishery to reduce the country's dependence on imported fish; the same applies for aquaculture, in order to complement production from the capture fisheries. The processing sector is also increasing in importance, especially with the increase in the number of capture fishery licenses, and the demand for quality and value-added products.
    Keywords: Fisheries ; Marine fisheries ; Fishery statistics ; Aquaculture development ; Aquaculture statistics ; Fish catch statistics ; Marine aquaculture ; Freshwater aquaculture ; Fishery development ; Marine ; Brackish ; Freshwater
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 6-14
    Format: 9
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  • 40
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    Analysis of additives: Determination of salt (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26843 | 23782 | 2019-11-15 07:52:55 | 26843 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Sodium chloride is an important additive for the production of fish jelly products. It extracts the salt soluble protein to give the gel strength of the final product. The paper provides the methodology in the determination of the amount of sodium chloride in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the salt in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Additives ; Food additives ; Salts ; Sodium chloride
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: D-5.1-D-5.2
    Format: 2
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  • 41
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    Microbiological procedure: Vibrio parahaemolyticus (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26851 | 23782 | 2019-11-14 01:29:31 | 26851 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Food poisoning due to Vibrio parahaemolyticus is a food-borne infection resulting from the ingestion of a large number of this organism (about 106-109 viable cells). The major symptoms are diarrhea and abdominal pain with headache, fever, and vomiting also occurring. The organisms are excreted during the acute stage of the illness after which they decrease rapidly. The differentiation of V. parahaemolyticus from other pathogenic species of Vibrio is based mainly on salt tolerance, Voges-Proskauer reaction, fermentation of sucrose, and growth at 43°C. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio parahaemolyticus ; Vibrio cholerae
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: E-8.1-E-8.6
    Format: 6
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  • 42
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    IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-02
    Description: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR). Treatment of cultured murine adipocytes with TNF-alpha was shown to induce serine phosphorylation of insulin receptor substrate 1 (IRS-1) and convert IRS-1 into an inhibitor of the IR tyrosine kinase activity in vitro. Myeloid 32D cells, which lack endogenous IRS-1, were resistant to TNF-alpha-mediated inhibition of IR signaling, whereas transfected 32D cells that express IRS-1 were very sensitive to this effect of TNF-alpha. An inhibitory form of IRS-1 was observed in muscle and fat tissues from obese rats. These results indicate that TNF-alpha induces insulin resistance through an unexpected action of IRS-1 to attenuate insulin receptor signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotamisligil, G S -- Peraldi, P -- Budavari, A -- Ellis, R -- White, M F -- Spiegelman, B M -- DK 42539/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):665-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571133" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/*metabolism ; Adipose Tissue/metabolism ; Animals ; Cells, Cultured ; Insulin/pharmacology ; Insulin Receptor Substrate Proteins ; Insulin Resistance/*physiology ; Male ; Mice ; Muscle, Skeletal/metabolism ; Obesity/*metabolism ; Phosphoproteins/metabolism/*physiology ; Phosphorylation ; Rats ; Rats, Zucker ; Receptor, Insulin/*antagonists & inhibitors/metabolism ; Serine/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/*pharmacology
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  • 43
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    CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-29
    Description: A 13.1-kilodalton protein, cysteine-rich neurotrophic factor (CRNF), was purified from the mollusk Lymnaea stagnalis by use of a binding assay on the p75 neurotrophin receptor. CRNF bound to p75 with nanomolar affinity but was not similar in sequence to neurotrophins or any other known gene product. CRNF messenger RNA expression was highest in adult foot subepithelial cells; in the central nervous system, expression was regulated by lesion. The factor evoked neurite outgrowth and modulated calcium currents in pedal motor neurons. Thus, CRNF may be involved in target-derived trophic support for motor neurons and could represent the prototype of another family of p75 ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fainzilber, M -- Smit, A B -- Syed, N I -- Wildering, W C -- Hermann -- van der Schors, R C -- Jimenez, C -- Li, K W -- van Minnen, J -- Bulloch, A G -- Ibanez, C F -- Geraerts, W P -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1540-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Berzelius Laboratories Building, Doktorsringen 12A, S-17177 Stockholm, Sweden. michael@cajal.mbb.ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8929417" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding, Competitive ; Calcium/metabolism ; Hemolymph/chemistry ; Humans ; Lymnaea/*chemistry ; Molecular Sequence Data ; Motor Neurons/ultrastructure ; Nerve Growth Factors/chemistry/genetics/isolation & ; purification/metabolism/*physiology ; Neurites/physiology ; RNA, Messenger/genetics/metabolism ; Receptor, Nerve Growth Factor ; Receptors, Nerve Growth Factor/*metabolism ; Recombinant Proteins/chemistry/isolation & purification/metabolism ; Tumor Cells, Cultured
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    Just how old is that DNA, anyway? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1996 May 10;272(5263):810.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629007" target="_blank"〉PubMed〈/a〉
    Keywords: *Amber/chemistry ; Amino Acids/*chemistry ; Animals ; DNA/*analysis/chemistry ; *Fossils ; History, Ancient ; *Paleontology ; Stereoisomerism
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  • 45
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    Estimating the age of the common ancestor of men from the ZFY intron (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fu, Y X -- Li, W H -- New York, N.Y. -- Science. 1996 May 31;272(5266):1356-7; author reply 1361-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bayes Theorem ; Biological Evolution ; Confidence Intervals ; DNA-Binding Proteins/*genetics ; *Genetics, Population ; Hominidae/*genetics ; Humans ; Introns/*genetics ; Kruppel-Like Transcription Factors ; Male ; Mutation ; Population Density ; Probability ; Time Factors ; Transcription Factors/*genetics ; Y Chromosome/*genetics
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  • 46
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    Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-09-27
    Description: The nuclear pore complex (NPC) is essential for the transit of molecules between the cytoplasm and nucleoplasm of a cell and until recently was thought to allow intermediate-sized molecules (relative molecular mass of approximately 10,000) to diffuse freely across the nuclear envelope. However, the depletion of calcium from the nuclear envelope of Xenopus laevis oocytes was shown to regulate the passage of intermediate-sized molecules. Two distinct conformational states of the NPC were observed by field emission scanning electron microscopy and atomic force microscopy. A central plug occluded the NPC channel after nuclear calcium stores had been depleted and free diffusion of intermediate-sized molecules had been blocked. Thus, the NPC conformation appears to gate molecular movement across the nuclear envelope.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perez-Terzic, C -- Pyle, J -- Jaconi, M -- Stehno-Bittel, L -- Clapham, D E -- New York, N.Y. -- Science. 1996 Sep 27;273(5283):1875-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Mayo Foundation, Rochester, MN 55905, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8791595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*metabolism ; Cell Nucleus/*metabolism ; Chelating Agents/pharmacology ; Diffusion ; Egtazic Acid/analogs & derivatives/pharmacology ; Female ; Inositol 1,4,5-Trisphosphate/pharmacology ; Microscopy, Atomic Force ; Microscopy, Electron ; Nuclear Envelope/metabolism/*ultrastructure ; Oocytes ; Xenopus laevis
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  • 47
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    The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-07-19
    Description: Signaling molecules are essential for vertebrate embryonic development. Here, two Xenopus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were identified and the protein product of lFng further characterized. The messenger RNA of lFng is supplied as a maternal message. Its product is a precursor protein consisting of pre-, pro-, and mature regions. The mature lunatic Fringe protein is secreted extracellularly, and it induced mesodermal tissue formation in animal cap assays. These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the Fringe proteins are a family of vertebrate signaling molecules.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080353/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080353/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, J Y -- Wen, L -- Zhang, W J -- Rao, Y -- R01 CA114197/CA/NCI NIH HHS/ -- R01 CA114197-01A2/CA/NCI NIH HHS/ -- R01 EY014576/EY/NEI NIH HHS/ -- R01 EY014576-03/EY/NEI NIH HHS/ -- R01 GM070967/GM/NIGMS NIH HHS/ -- R01 GM070967-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jul 19;273(5273):355-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662522" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Blastocyst/metabolism ; Cell Line ; Culture Media, Conditioned ; Culture Techniques ; Drosophila Proteins ; Embryo, Nonmammalian/metabolism ; Embryonic Development ; *Embryonic Induction ; *Glycosyltransferases ; Mesoderm/*metabolism ; Molecular Sequence Data ; *N-Acetylglucosaminyltransferases ; Polymerase Chain Reaction ; Protein Processing, Post-Translational ; Proteins/chemistry/genetics/*physiology/secretion ; RNA, Messenger/genetics/metabolism ; *Signal Transduction ; Xenopus/*embryology/genetics ; *Xenopus Proteins
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  • 48
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    Toxicology of a PFPE surfactant (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnston, K P -- Randolph, T -- Bright, F -- Howdle, S -- New York, N.Y. -- Science. 1996 Jun 21;272(5269):1726.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight/drug effects ; Ethers/*toxicity ; Fluorocarbons/*toxicity ; Liver/*drug effects ; Organ Size/drug effects ; Rats ; Surface-Active Agents/*toxicity
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  • 49
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    Visualization of gene expression in living adult Drosophila (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-10-11
    Description: To identify genes involved in the patterning of adult structures, Gal4-UAS (upstream activating site) technology was used to visualize patterns of gene expression directly in living flies. A large number of Gal4 insertion lines were generated and their expression patterns were studied. In addition to identifying several characterized developmental genes, the approach revealed previously unsuspected genetic subdivisions of the thorax, which may control the disposition of pattern elements. The boundary between two of these domains coincides with localized expression of the signaling molecule wingless.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Calleja, M -- Moreno, E -- Pelaz, S -- Morata, G -- RG-372/94/RG/CSR NIH HHS/ -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):252-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centro de Biologia Molecular, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain. gmorata@mvax.cbm.uam.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA-Binding Proteins ; Drosophila/*genetics/growth & development ; *Drosophila Proteins ; Fungal Proteins/genetics ; *Gene Expression Regulation, Developmental ; Gene Transfer Techniques ; Genes ; Genes, Developmental ; *Genes, Insect ; Proto-Oncogene Proteins/genetics ; *Saccharomyces cerevisiae Proteins ; Thorax/growth & development ; Transcription Factors/genetics ; Wnt1 Protein
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  • 50
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    Disputed results now just a footnote (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-07-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):174-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8668989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Anti-Idiotypic/*immunology ; Hybridomas ; Immune System/*immunology ; Immunoglobulin Idiotypes/biosynthesis/*immunology ; Mice ; Mice, Transgenic
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  • 51
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    Abnormal centrosome amplification in the absence of p53 (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-03-22
    Description: The centrosome plays a vital role in mitotic fidelity, ensuring establishment of bipolar spindles and balanced chromosome segregation. Centrosome duplication occurs only once during the cell cycle and is therefore highly regulated. Here, it is shown that in mouse embryonic fibroblasts (MEFs) lacking the p53 tumor suppressor protein, multiple copies of functionally competent centrosomes are generated during a single cell cycle. In contrast, MEFs prepared from normal mice or mice deficient in the retinoblastoma tumor suppressor gene product do not display these abnormalities. The abnormally amplified centrosomes profoundly affect mitotic fidelity, resulting in unequal segregation of chromosomes. These observations implicate p53 in the regulation of centrosome duplication and suggest one possible mechanism by which the loss of p53 may cause genetic instability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fukasawa, K -- Choi, T -- Kuriyama, R -- Rulong, S -- Vande Woude, G F -- New York, N.Y. -- Science. 1996 Mar 22;271(5256):1744-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596939" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Cells, Cultured ; Centrosome/*metabolism ; Culture Media ; Fibroblasts ; Genes, Retinoblastoma ; Genes, p53 ; *Interphase ; Mice ; *Mitosis ; Spindle Apparatus/metabolism/ultrastructure ; Tumor Suppressor Protein p53/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 52
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    Role of lipid polymorphism in pulmonary surfactant (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-07-19
    Description: The development of artificial surfactants for the treatment of respiratory distress syndrome (RDS) requires lipid systems that can spread rapidly from solution to the air-water interface. Because hydration-repulsion forces stabilize liposomal bilayers and oppose spreading, liposome systems that undergo geometric rearrangement from the bilayer (lamellar) phase to the hexagonal II (HII) phase could hasten lipid transfer to the air-water interface through unstable transition intermediates. A liposome system containing dipalmitoylphosphatidylcholine was designed; the system is stable at 23 degrees C but undergoes transformation to the HII phase as the temperature increases to 37 degrees C. The spreading of lipid from this system to the air-water interface was rapid at 37 degrees C but slow at 23 degrees C. When tested in vivo in a neonatal rabbit model, such systems elicited an onset of action equal to that of native human surfactant. These findings suggest that lipid polymorphic phase behavior may have a crucial role in the effective functioning of pulmonary surfactant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perkins, W R -- Dause, R B -- Parente, R A -- Minchey, S R -- Neuman, K C -- Gruner, S M -- Taraschi, T F -- Janoff, A S -- New York, N.Y. -- Science. 1996 Jul 19;273(5273):330-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Liposome Company, Inc., 1 Research Way, Princeton, NJ 08540, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662513" target="_blank"〉PubMed〈/a〉
    Keywords: 1,2-Dipalmitoylphosphatidylcholine/*chemistry/pharmacology ; Animals ; Animals, Newborn ; Chemistry, Physical ; Cholesterol/*chemistry/pharmacology ; Lipid Bilayers ; Liposomes/*chemistry/pharmacology ; Lung Compliance/*drug effects ; Magnetic Resonance Spectroscopy ; Phosphatidylethanolamines/*chemistry/pharmacology ; Physicochemical Phenomena ; Pulmonary Surfactants/*chemistry/pharmacology ; Rabbits ; Surface Properties ; Surface Tension ; Temperature ; X-Ray Diffraction
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  • 53
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    Hippocampal cell death (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cahill, L -- Haigler, H J -- New York, N.Y. -- Science. 1996 May 31;272(5266):1251.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650532" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*pharmacology ; *Aging ; Animals ; Cell Death ; Enkephalin, Methionine/*pharmacology ; Hippocampus/*cytology ; Humans ; Memory ; Pyramidal Cells/cytology/*drug effects/physiology ; Rats
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  • 54
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    RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-11-22
    Description: The RAC guanine nucleotide binding proteins regulate multiple biological activities, including actin polymerization, activation of the Jun kinase (JNK) cascade, and cell proliferation. RAC effector loop mutants were identified that separate the ability of RAC to interact with different downstream effectors. One mutant of activated human RAC protein, RACV12H40 (with valine and histidine substituted at position 12 and 40, respectively), was defective in binding to PAK3, a Ste20-related p21-activated kinase (PAK), but bound to POR1, a RAC-binding protein. This mutant failed to stimulate PAK and JNK activity but still induced membrane ruffling and mediated transformation. A second mutant, RACV12L37 (with leucine substituted at position 37), which bound PAK but not POR1, induced JNK activation but was defective in inducing membrane ruffling and transformation. These results indicate that the effects of RAC on the JNK cascade and on actin polymerization and cell proliferation are mediated by distinct effector pathways that diverge at the level of RAC itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joneson, T -- McDonough, M -- Bar-Sagi, D -- Van Aelst, L -- CA55360/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1374-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, NY 11794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910277" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Actins/*metabolism ; *Adaptor Proteins, Signal Transducing ; Animals ; COS Cells ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Carrier Proteins/metabolism ; *Cell Division ; Cell Line ; Cell Line, Transformed ; Cell Membrane/ultrastructure ; Enzyme Activation ; GTP-Binding Proteins/genetics/metabolism/*physiology ; Humans ; JNK Mitogen-Activated Protein Kinases ; Mice ; *Mitogen-Activated Protein Kinases ; Mutagenesis ; Protein-Serine-Threonine Kinases/metabolism ; Rats ; Transfection ; p21-Activated Kinases ; rac GTP-Binding Proteins
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  • 55
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    Categorical perception of sound frequency by crickets (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-09-13
    Description: Partitioning continuously varying stimuli into categories is a fundamental problem of perception. One solution to this problem, categorical perception, is known primarily from human speech, but also occurs in other modalities and in some mammals and birds. Categorical perception was tested in crickets by using two paradigms of human psychophysics, labeling and habituation-dishabituation. The results show that crickets divide sound frequency categorically between attractive (〈16 kilohertz) and repulsive (〉16 kilohertz) sounds. There is sharp discrimination between these categories but no discrimination between different frequencies of ultrasound. This demonstration of categorical perception in an invertebrate suggests that categorical perception may be a basic and widespread feature of sensory systems, from humans to invertebrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyttenbach, R A -- May, M L -- Hoy, R R -- K05-MH1148/MH/NIMH NIH HHS/ -- R01-CD00103/CD/ODCDC CDC HHS/ -- T32-MN15793/MN/OMHHE CDC HHS/ -- etc. -- New York, N.Y. -- Science. 1996 Sep 13;273(5281):1542-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853-2702, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Auditory Perception ; Gryllidae/*physiology ; *Pitch Discrimination
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 56
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    U1-mediated exon definition interactions between AT-AC and GT-AG introns (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-08
    Description: A minor class of metazoan introns has well-conserved splice sites with 5'-AU-AC-3' boundaries, compared to the 5'-GU-AG-3' boundaries and degenerate splice sites of conventional introns. Splicing of the AT-AC intron 2 of a sodium channel (SCN4A) precursor messenger RNA in vitro did not require inhibition of conventional splicing and required adenosine triphosphate, magnesium, and U12 small nuclear RNA (snRNA). When exon 3 was followed by the 5' splice site from the downstream conventional intron, splicing of intron 2 was greatly stimulated. This effect was U1 snRNA-dependent, unlike the basal AT-AC splicing reaction. Therefore, U1-mediated exon definition interactions can coordinate the activities of major and minor spliceosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, Q -- Krainer, A R -- GM42699/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):1005-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724-2208, USA. krainer@cshl.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8875927" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Animals ; *Exons ; HeLa Cells ; Humans ; *Introns ; Magnesium/pharmacology ; *RNA Splicing ; RNA, Small Nuclear/*metabolism ; Ribonucleoprotein, U1 Small Nuclear/metabolism ; Ribonucleoproteins, Small Nuclear/metabolism ; Sodium Channels/*genetics ; Spliceosomes/genetics
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    Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-06-07
    Description: The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome. Ectopically expressed mouse Twist (Mtwist) was shown to inhibit myogenesis by blocking DNA binding by MyoD, by titrating E proteins, and by inhibiting trans-activation by MEF2. For inhibition of MEF2, Mtwist required heterodimerization with E proteins and an intact basic domain and carboxyl-terminus. Thus, Mtwist inhibits both families of myogenic regulators and may regulate myotome formation temporally or spatially.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spicer, D B -- Rhee, J -- Cheung, W L -- Lassar, A B -- 5-F32-AR08214-02/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1476-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633239" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basic Helix-Loop-Helix Transcription Factors ; Cell Differentiation ; Cell Line ; Creatine Kinase/genetics ; DNA/metabolism ; DNA-Binding Proteins/*antagonists & inhibitors/chemistry/genetics/metabolism ; Drosophila ; Drosophila Proteins ; Helix-Loop-Helix Motifs/*physiology ; Inhibitor of Differentiation Protein 1 ; MEF2 Transcription Factors ; Mice ; Muscle, Skeletal/*cytology/metabolism ; MyoD Protein/metabolism/physiology ; Myogenic Regulatory Factors ; Nuclear Proteins/chemistry/metabolism/*physiology ; *Repressor Proteins ; TCF Transcription Factors ; Transcription Factor 7-Like 1 Protein ; Transcription Factors/*antagonists & ; inhibitors/chemistry/genetics/metabolism/physiology ; Transcriptional Activation ; Transfection ; Twist Transcription Factor
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    Identification of BIME as a subunit of the anaphase-promoting complex (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-15
    Description: The initiation of anaphase and exit from mitosis require the activation of a proteolytic system that ubiquitinates and degrades cyclin B. The regulated component of this system is a large ubiquitin ligase complex, termed the anaphase-promoting complex (APC) or cyclosome. Purified Xenopus laevis APC was found to be composed of eight major subunits, at least four of which became phosphorylated in mitosis. In addition to CDC27, CDC16, and CDC23, APC contained a homolog of Aspergillus nidulans BIME, a protein essential for anaphase. Because mutation of bimE can bypass the interphase arrest induced by either nimA mutation or unreplicated DNA, it appears that ubiquitination catalyzed by APC may also negatively regulate entry into mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, J M -- King, R W -- Hoog, C -- Kirschner, M W -- New York, N.Y. -- Science. 1996 Nov 15;274(5290):1199-201.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8895470" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *Anaphase ; Animals ; Aspergillus/chemistry/cytology/metabolism ; Cell Cycle Proteins/*chemistry/metabolism ; Cyclins/metabolism ; Electrophoresis, Polyacrylamide Gel ; Fungal Proteins/analysis/*chemistry/genetics/metabolism ; Ligases/*chemistry/metabolism ; *Mitosis ; Molecular Sequence Data ; Mutation ; Ovum ; Phosphorylation ; Ubiquitin-Protein Ligases ; Xenopus laevis
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    Appetite-suppressing effects of urocortin, a CRF-related neuropeptide (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-09-13
    Description: The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympathetic activity, decreases in parasympathetic outflow, and decreases in appetitive behavior. Urocortin, a neuropeptide related to CRF, binds with high affinity to the CRF2 receptor, is more potent than CRF in suppressing appetite, but is less potent than CRF in producing anxiety-like effects and activation. Doses as low as 10 nanograms injected intracerebroventricularly were effective in decreasing food intake in food-deprived and free-feeding rats. These results suggest that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spina, M -- Merlo-Pich, E -- Chan, R K -- Basso, A M -- Rivier, J -- Vale, W -- Koob, G F -- 1 F05 TW05262/TW/FIC NIH HHS/ -- DK 26741/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 Sep 13;273(5281):1561-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuropharmacology, Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Appetite Depressants/administration & dosage/metabolism/*pharmacology ; Behavior, Animal/drug effects ; Blood Pressure/drug effects ; Carrier Proteins/metabolism ; Corticotropin-Releasing Hormone/administration & dosage/metabolism/*pharmacology ; Dose-Response Relationship, Drug ; Eating/drug effects ; Fasting ; Injections, Intraventricular ; Motor Activity/drug effects ; Rats ; Rats, Wistar ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Urocortins ; Urotensins/pharmacology
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    Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-02-09
    Description: The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. In quiescent fibroblasts, ectopic expression of activated H-RAS (H-RASV12, where V12 indicates valine-12) induces membrane ruffling, mitogen-activated protein (MAP) kinase activation, and stimulation of DNA synthesis. A mutant of activated H-RAS, H-RASV12C40 (where C40 indicates cysteine-40), was identified that was defective for MAP kinase activation and stimulation of DNA synthesis, but retained the ability to induce membrane ruffling. Another mutant of activated H-RAS, H-RASV12S35 (where S35 indicates serine-35), which activates MAP kinase, was defective for stimulation of membrane ruffling and induction of DNA synthesis. Expression of both mutants resulted in a stimulation of DNA synthesis that was comparable to that induced by H-RASV12. These results indicate that membrane ruffling and activation of MAP kinase represent distinct RAS effector pathways and that input from both pathways is required for the mitogenic activity of RAS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joneson, T -- White, M A -- Wigler, M H -- Bar-Sagi, D -- CA 55360/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 9;271(5250):810-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8628998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Division ; Cell Line ; Cell Membrane/*ultrastructure ; DNA/biosynthesis ; Enzyme Activation ; GTP-Binding Proteins/genetics/metabolism ; Microinjections ; Mutation ; Plasmids ; Protein-Serine-Threonine Kinases/*metabolism ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-raf ; Rats ; Signal Transduction ; rac GTP-Binding Proteins ; ras Proteins/genetics/*metabolism
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    An enhanced immune response in mice lacking the transcription factor NFAT1 (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-05-10
    Description: Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1 -/- mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1 -/- mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xanthoudakis, S -- Viola, J P -- Shaw, K T -- Luo, C -- Wallace, J D -- Bozza, P T -- Luk, D C -- Curran, T -- Rao, A -- CA42471/CA/NCI NIH HHS/ -- GM46227/GM/NIGMS NIH HHS/ -- P30 CA21765/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 May 10;272(5263):892-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurogenetics Program, Department of CNS Research, Hoffmann-LaRoche, Nutley, NJ 07110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629027" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/immunology ; Cell Line ; Cytokines/biosynthesis ; DNA-Binding Proteins/genetics/*physiology ; Eosinophils/immunology ; Gene Targeting ; Hypersensitivity/*immunology ; *Immunity ; Immunoglobulin E/biosynthesis ; Immunologic Memory ; Leishmania major/immunology ; *Lymphocyte Activation ; Mice ; Molecular Sequence Data ; NFATC Transcription Factors ; *Nuclear Proteins ; Ovalbumin/immunology ; T-Lymphocytes/immunology ; Transcription Factors/genetics/*physiology
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    Programmed cell death (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fulton, A B -- New York, N.Y. -- Science. 1996 Oct 4;274(5284):20-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8848715" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; *Biological Evolution ; *Chlorophyta ; *Plants
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    Antigen presentation and T cell development in H2-M-deficient mice (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-03-01
    Description: HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the thymus. Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fung-Leung, W P -- Surh, C D -- Liljedahl, M -- Pang, J -- Leturcq, D -- Peterson, P A -- Webb, S R -- Karlsson, L -- New York, N.Y. -- Science. 1996 Mar 1;271(5253):1278-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉R. W. Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638109" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigen Presentation ; Antigen-Presenting Cells/*immunology ; Antigens, Differentiation, B-Lymphocyte/immunology/metabolism ; Base Sequence ; CD4-Positive T-Lymphocytes/*immunology ; Cells, Cultured ; Gene Targeting ; Histocompatibility Antigens Class II/genetics/*immunology/metabolism ; Isoantigens/immunology ; Lymphocyte Activation ; Mice ; Molecular Sequence Data ; Mutation
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    Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-16
    Description: A signaling pathway has been elucidated whereby growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription. Growth factor-stimulated CREB phosphorylation at serine-133 is mediated by the RAS-mitogen-activated protein kinase (MAPK) pathway. MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xing, J -- Ginty, D D -- Greenberg, M E -- CA43855/CA/NCI NIH HHS/ -- NS34814-01/NS/NINDS NIH HHS/ -- P30-HD18655/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 16;273(5277):959-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688081" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Line ; Cell Nucleus/metabolism ; Cyclic AMP Response Element-Binding Protein/*metabolism ; Epidermal Growth Factor/pharmacology ; *Gene Expression Regulation ; Growth Substances/*pharmacology ; Humans ; Molecular Sequence Data ; Nerve Growth Factors/pharmacology ; PC12 Cells ; Phosphorylation ; Protein-Serine-Threonine Kinases/*metabolism ; Rats ; Ribosomal Protein S6 Kinases ; *Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured ; ras Proteins/metabolism
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    Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-08-09
    Description: STAT proteins (signal transducers and activators of transcription) activate distinct target genes despite having similar DNA binding preferences. The transcriptional specificity of STAT proteins was investigated on natural STAT binding sites near the interferon-gamma gene. These sites are arranged in multiple copies and required cooperative interactions for STAT binding. The conserved amino-terminal domain of STAT proteins was required for cooperative DNA binding, although this domain was not essential for dimerization or binding to a single site. Cooperative binding interactions enabled the STAT proteins to recognize variations of the consensus site. These sites can be specific for the different STAT proteins and may function to direct selective transcriptional activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, X -- Sun, Y L -- Hoey, T -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):794-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670419" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites ; Cell Line ; DNA/*metabolism ; DNA-Binding Proteins/chemistry/immunology/*metabolism ; Interferon-gamma/genetics ; Introns ; Molecular Sequence Data ; Mutation ; Oligodeoxyribonucleotides/metabolism ; Promoter Regions, Genetic ; STAT1 Transcription Factor ; STAT4 Transcription Factor ; Sequence Deletion ; Signal Transduction ; Trans-Activators/chemistry/immunology/*metabolism ; *Transcriptional Activation
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    IRAK: a kinase associated with the interleukin-1 receptor (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-02-23
    Description: The pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation of the transcription regulator nuclear factor kappa B (NF-kappa B). A protein kinase designated IRAK (IL-1 receptor-associated kinase) was purified, and its complementary DNA was molecularly cloned. When human embryonic kidney cells (cell line 293) over-expressing IL-1RI or HeLa cells were exposed to IL-1, IRAK rapidly associated with the IL-1RI complex and was phosphorylated. The primary amino acid sequence of IRAK shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-kappa B homolog in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cao, Z -- Henzel, W J -- Gao, X -- New York, N.Y. -- Science. 1996 Feb 23;271(5252):1128-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Department, Tularik, Incorporated, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599092" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Cloning, Molecular ; DNA, Complementary/genetics ; Drosophila ; *Drosophila Proteins ; HeLa Cells ; Humans ; Interleukin-1/*metabolism/pharmacology ; Interleukin-1 Receptor-Associated Kinases ; Molecular Sequence Data ; Phosphorylation ; Protein Kinases/chemistry/genetics/isolation & purification/*metabolism ; Protein-Serine-Threonine Kinases/chemistry ; Receptors, Interleukin-1/*metabolism ; Transfection
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    Resistance to Leishmania major induced by tolerance to a single antigen (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-10-18
    Description: In mice, susceptibility to Leishmania major is associated with the early expansion of T helper 2 cells (TH2) cells, but nothing is known of the specificity of these cells. A previously identified antigen, Leishmania homolog of receptors for activated C kinase (LACK), was found to be the focus of this initial response. Mice made tolerant to LACK by the transgenic expression of the antigen in the thymus exhibited both a diminished TH2 response and a healing phenotype. Thus, T cells that are activated early and are reactive to a single antigen play a pivotal role in directing the immune response to the entire parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Julia, V -- Rassoulzadegan, M -- Glaichenhaus, N -- New York, N.Y. -- Science. 1996 Oct 18;274(5286):421-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8832890" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/*immunology ; Crosses, Genetic ; Female ; Immune Tolerance ; Immunity, Innate ; Immunization ; Interleukin-4/secretion ; Interleukin-5/secretion ; Leishmania major/*immunology ; Leishmaniasis, Cutaneous/*immunology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Molecular Sequence Data ; Phenotype ; Protozoan Proteins/*immunology ; Th1 Cells/immunology ; Th2 Cells/*immunology
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    Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-20
    Description: Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfeifer, A -- Aszodi, A -- Seidler, U -- Ruth, P -- Hofmann, F -- Fassler, R -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2082-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut f-ur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, D-80802 M-unchen, Germany. pfeifer@ipt.med.tu-muenchen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953039" target="_blank"〉PubMed〈/a〉
    Keywords: 8-Bromo Cyclic Adenosine Monophosphate/pharmacology ; Animals ; Bacterial Toxins/toxicity ; Body Water/secretion ; *Bone Development ; Crosses, Genetic ; Cyclic GMP/analogs & derivatives/metabolism/pharmacology ; Cyclic GMP-Dependent Protein Kinases/deficiency/genetics/*metabolism ; Diarrhea/physiopathology ; Dwarfism/*enzymology/genetics/pathology ; Enterotoxins/toxicity ; Escherichia coli Proteins ; Female ; Gene Deletion ; Growth Plate/enzymology/pathology ; Intestinal Mucosa/*secretion ; Male ; Mice ; Mice, Inbred C57BL ; Osteogenesis ; Signal Transduction
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    G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: Missense mutations in the 695-amino acid form of the amyloid precursor protein (APP695) cosegregate with disease phenotype in families with dominantly inherited Alzheimer's disease. These mutations convert valine at position 642 to isoleucine, phenylalanine, or glycine. Expression of these mutant proteins, but not of normal APP695, was shown to induce nucleosomal DNA fragmentation in neuronal cells. Induction of DNA fragmentation required the cytoplasmic domain of the mutants and appeared to be mediated by heterotrimeric guanosine triphosphate-binding proteins (G proteins).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamatsuji, T -- Matsui, T -- Okamoto, T -- Komatsuzaki, K -- Takeda, S -- Fukumoto, H -- Iwatsubo, T -- Suzuki, N -- Asami-Odaka, A -- Ireland, S -- Kinane, T B -- Giambarella, U -- Nishimoto, I -- New York, N.Y. -- Science. 1996 May 31;272(5266):1349-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650548" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/chemistry/genetics/*physiology ; Animals ; Apoptosis ; Base Sequence ; Culture Media, Conditioned ; DNA/*metabolism ; GTP-Binding Proteins/*physiology ; Humans ; Hybrid Cells ; Mice ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; Neurons/cytology/*metabolism ; Nucleosomes/*metabolism ; Peptide Fragments/metabolism ; Rats ; Transfection
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-30
    Description: In the mitochondria of trypanosomatid protozoa the precursors of messenger RNAs (pre-mRNAs) have their coding information remodeled by the site-specific insertion and deletion of uridylate (U) residues. Small trans-acting guide RNAs (gRNAs) supply the genetic information for this RNA editing. An in vitro system was developed to study the mechanism of U insertion into pre-mRNA. U-insertion editing occurs through a series of enzymatic steps that begin with gRNA-directed pre-mRNA cleavage. Inserted U's are derived from free uridine triphosphate and are added to the 3' terminus of a 5' pre-mRNA cleavage product. gRNA specifies edited RNA sequence at the subsequent ligation step by base pairing-mediated juxtaposition of the 3' cleavage product and the processed 5' cleavage product. gRNA/pre-mRNA chimeras, purported intermediates, seem to be abortive end products of the same reaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kable, M L -- Seiwert, S D -- Heidmann, S -- Stuart, K -- GM08347/GM/NIGMS NIH HHS/ -- GM42188/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1189-95.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Seattle Biomedical Research Institute, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703045" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Crithidia fasciculata/genetics/metabolism ; Mitochondria/genetics/metabolism ; Models, Genetic ; Molecular Sequence Data ; RNA/metabolism ; *RNA Editing ; RNA Precursors/*metabolism ; RNA, Guide/*metabolism ; RNA, Messenger/*metabolism ; RNA, Protozoan/metabolism ; Trypanosoma brucei brucei/genetics/metabolism ; Trypanosomatina/*genetics/metabolism ; Uridine Monophosphate/*metabolism ; Uridine Triphosphate/metabolism
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    Hippocampal neurodegeneration in aging (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, M -- Landfield, P W -- McEwen, B -- Meaney, M J -- Rapp, P R -- Sapolsky, R -- West, M J -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):484-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927995" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cell Count ; Hippocampus/*cytology ; Humans ; *Nerve Degeneration ; Neurons/*cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-21
    Description: ZPR1 is a zinc finger protein that binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Deletion analysis demonstrated that this binding interaction is mediated by the zinc fingers of ZPR1 and subdomains X and XI of the EGFR tyrosine kinase. Treatment of mammalian cells with EGF caused decreased binding of ZPR1 to the EGFR and the accumulation of ZPR1 in the nucleus. The effect of EGF to regulate ZPR1 binding is dependent on tyrosine phosphorylation of the EGFR. ZPR1 therefore represents a prototype for a class of molecule that binds to the EGFR and is released from the receptor after activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galcheva-Gargova, Z -- Konstantinov, K N -- Wu, I H -- Klier, F G -- Barrett, T -- Davis, R J -- R01-CA58396/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Jun 21;272(5269):1797-802.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650580" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Carrier Proteins/chemistry/*metabolism/secretion ; Cell Line ; Cell Nucleus/metabolism ; Cloning, Molecular ; Cytoplasm/metabolism ; Epidermal Growth Factor/pharmacology ; Humans ; Immunoblotting ; Male ; Mice ; Molecular Sequence Data ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein Structure, Secondary ; RNA, Messenger/genetics/metabolism ; Receptor, Epidermal Growth Factor/chemistry/*metabolism ; Testis/metabolism ; Type C Phospholipases/metabolism ; Vanadates/pharmacology ; *Zinc Fingers ; src Homology Domains
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  • 73
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    Corticofugal modulation of time-domain processing of biosonar information in bats (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-23
    Description: The Jamaican mustached bat has delay-tuned neurons in the inferior colliculus, medial geniculate body, and auditory cortex. The responses of these neurons to an echo are facilitated by a biosonar pulse emitted by the bat when the echo returns with a particular delay from a target located at a particular distance. Electrical stimulation of cortical delay-tuned neurons increases the delay-tuned responses of collicular neurons tuned to the same echo delay as the cortical neurons and decreases those of collicular neurons tuned to different echo delays. Cortical neurons improve information processing in the inferior colliculus by way of the corticocollicular projection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, J -- Suga, N -- DC 00175/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 23;273(5278):1100-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Washington University, One Brookings Drive, St. Louis, MO 63130, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688095" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Animals ; Auditory Cortex/*physiology ; Chiroptera/*physiology ; *Echolocation ; Electric Stimulation ; Evoked Potentials, Auditory ; Inferior Colliculi/*physiology ; Neurons/physiology
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    A docking receptor for HDL cholesterol esters (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinberg, D -- New York, N.Y. -- Science. 1996 Jan 26;271(5248):460-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California at San Diego, La Jolla 92093-0613, USA. dsteinberg@UCSD.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8560256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD36/genetics/*metabolism ; Biological Transport ; *Carrier Proteins ; Cholesterol/metabolism ; Cholesterol Esters/*metabolism ; Gene Targeting ; Lipoproteins, HDL/genetics/*metabolism ; Liver/metabolism ; *Membrane Proteins ; Mice ; *RNA-Binding Proteins ; *Receptors, Immunologic ; Receptors, Lipoprotein/*metabolism ; Receptors, Scavenger ; Scavenger Receptors, Class B
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    German genome program. The right mix of form and function (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahn, P -- New York, N.Y. -- Science. 1996 Aug 2;273(5275):570-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8701304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Genome ; Germany ; *Human Genome Project/economics/organization & administration ; Humans ; Research Support as Topic ; *Sequence Analysis, DNA/economics
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    The elements of immunity (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, R B -- Miller, L J -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600524" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Immunity ; Infection/immunology ; Lymphocytes/immunology
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  • 77
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    Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-05
    Description: Cystic fibrosis (CF) patients are hypersusceptible to chronic Pseudomonas aeruginosa lung infections. Cultured human airway epithelial cells expressing the delta F508 allele of the cystic fibrosis transmembrane conductance regulator (CFTR) were defective in uptake of P. aeruginosa compared with cells expressing the wild-type allele. Pseudomonas aeruginosa lipopolysaccharide (LPS)-core oligosaccharide was identified as the bacterial ligand for epithelial cell ingestion; exogenous oligosaccharide inhibited bacterial ingestion in a neonatal mouse model, resulting in increased amounts of bacteria in the lungs. CFTR may contribute to a host-defense mechanism that is important for clearance of P. aeruginosa from the respiratory tract.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677515/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677515/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pier, G B -- Grout, M -- Zaidi, T S -- Olsen, J C -- Johnson, L G -- Yankaskas, J R -- Goldberg, J B -- AI22806/AI/NIAID NIH HHS/ -- AI35674/AI/NIAID NIH HHS/ -- HL42384/HL/NHLBI NIH HHS/ -- R01 HL058398/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1996 Jan 5;271(5245):64-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115-5899, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cell Line, Transformed ; Cystic Fibrosis/*complications/genetics/microbiology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics/*physiology ; Disease Susceptibility ; Epithelium/microbiology ; Humans ; Lipopolysaccharides/pharmacology ; Lung/microbiology ; Mice ; Mice, Inbred BALB C ; Pseudomonas Infections/*etiology/microbiology ; Pseudomonas aeruginosa/*physiology ; Respiratory System/*microbiology ; Respiratory Tract Infections/*etiology/microbiology
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    Myc and Max homologs in Drosophila (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-11-29
    Description: The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallant, P -- Shiio, Y -- Cheng, P F -- Parkhurst, S M -- Eisenman, R N -- R01CA47138/CA/NCI NIH HHS/ -- R01GM47852/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1523-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle WA 98104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8929412" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Basic-Leucine Zipper Transcription Factors ; Cloning, Molecular ; DNA Transposable Elements ; DNA, Complementary ; DNA-Binding Proteins/chemistry/genetics/metabolism ; Dimerization ; *Drosophila Proteins ; Drosophila melanogaster/chemistry/*genetics/growth & development/metabolism ; Female ; Gene Expression Regulation, Developmental ; Genes, Insect ; Genes, myc ; *Helix-Loop-Helix Motifs ; Humans ; Molecular Sequence Data ; Oligonucleotide Probes/metabolism ; Ovary/metabolism ; Proto-Oncogene Proteins c-myc/chemistry/genetics/metabolism ; RNA, Messenger/genetics/metabolism ; Transcription Factors/chemistry/genetics/*metabolism ; Transcription, Genetic
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    Arousal: revisiting the reticular activating system (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steriade, M -- New York, N.Y. -- Science. 1996 Apr 12;272(5259):225-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Neurophysiologie, Department de Physiologie, Universite Laval, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8602506" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Arousal/*physiology ; Cerebral Cortex/physiology ; Electroencephalography ; Humans ; Neural Pathways ; Neuronal Plasticity ; Reticular Formation/*physiology ; Sleep/physiology ; Thalamic Nuclei/physiology
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    CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-09-27
    Description: The role of CD40 ligand (CD40L) in the primary activation of T cells is not clear. The cellular and humoral immune responses to adenoviral vectors in a murine model of liver-directed gene transfer were studied to define the mechanisms responsible for CD40L-dependent T cell priming. CD40L-deficient mice did not develop effective cytotoxic T cells to transduced hepatocytes, and T cell-dependent B cell responses were absent. Full reconstitution of cellular and humoral immunity was achieved in CD40L-deficient mice by administration of an activating antibody to CD40 that increased expression of B7.2 on spleen cells. Wild-type mice could be made nonresponsive to vector by administration of antibodies to B7. Thus, CD40L-dependent activation of T cells occurs through signaling of CD40 in the antigen-presenting cell to enhance requisite costimulatory pathways that include B7.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Y -- Wilson, J M -- New York, N.Y. -- Science. 1996 Sep 27;273(5283):1862-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8791591" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae/genetics ; Animals ; Antigen-Presenting Cells/immunology ; Antigens, CD/*metabolism ; Antigens, CD28/*metabolism ; Antigens, CD86 ; CD4-Positive T-Lymphocytes/immunology ; CD40 Ligand ; Female ; Gene Transfer Techniques ; Genetic Vectors ; Liver/immunology/metabolism ; *Lymphocyte Activation ; Membrane Glycoproteins/*metabolism ; Mice ; Mice, Inbred C57BL ; *Signal Transduction ; T-Lymphocytes/*immunology ; T-Lymphocytes, Cytotoxic/immunology ; Transgenes
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    Evaluating electrostatic contributions to binding with the use of protein charge ladders (1996)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1996-04-26
    Description: Electrostatic interactions between charges on ligands and charges on proteins that are remote from the binding interface can influence the free energy of binding (delta Gb). The binding affinities between charged ligands and the members of a charge ladder of bovine carbonic anhydrase (CAII) constructed by random acetylation of the amino groups on its surface were measured by affinity capillary electrophoresis (ACE). The values of delta Gb derived from this analysis correlated approximately linearly with the charge. Opposite charges on the ligand and the members of the charge ladder of CAII were stabilizing; like charges were destabilizing. The combination of ACE and protein charge ladders provides a tool for quantitatively examining the contributions of electrostatics to free energies of molecular recognition in biology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gao, J -- Mammen, M -- Whitesides, G M -- GM51559/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 26;272(5261):535-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614800" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Binding Sites ; Carbonic Anhydrases/*chemistry/*metabolism ; Cattle ; Electrochemistry ; Electrophoresis, Capillary ; Ligands ; Models, Chemical ; Molecular Weight ; Protein Conformation ; Sulfonamides/metabolism ; Thermodynamics
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    Spread of synaptic depression mediated by presynaptic cytoplasmic signaling (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-17
    Description: Postsynaptic activity may modulate presynaptic functions by transsynaptic retrograde signals. At developing neuromuscular synapses in Xenopus nerve-muscle cultures, a brief increase in the cytosolic calcium ion (Ca2+) concentration in postsynaptic myocytes induced persistent depression of presynaptic transmitter secretion. This depression spread to distant synapses formed by the same neuron. Clearance of extracellular fluid did not prevent the spread of depression, and depression could not be induced by increasing the Ca2+ concentration in a nearby myocyte not in contact with the presynaptic neuron. Thus, the spread of depression is mediated by signaling in the presynaptic cytoplasm, rather than by a retrograde factor in the extracellular space.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cash, S -- Zucker, R S -- Poo, M M -- NS15114/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 May 17;272(5264):998-1001.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638143" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*metabolism ; Cells, Cultured ; Chelating Agents ; Cytoplasm/*metabolism ; Egtazic Acid/analogs & derivatives ; Evoked Potentials ; Muscles/cytology/innervation/physiology ; Neurites/physiology ; Neuromuscular Junction/metabolism/*physiology ; Photolysis ; Presynaptic Terminals/physiology ; *Signal Transduction ; Synapses/*physiology ; *Synaptic Transmission ; Ultraviolet Rays ; Xenopus
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Scientists angle for answers (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1996 Dec 13;274(5294):1837-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8984641" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/chemically induced/*veterinary ; Estradiol/analysis/toxicity ; Estrogens/*analysis/toxicity ; Estrone/analysis/toxicity ; Ethinyl Estradiol/analysis ; Female ; Fish Diseases/*chemically induced ; Gonadal Steroid Hormones/analysis ; Humans ; Male ; Sewage/*chemistry ; Vitellogenins/biosynthesis ; Water Pollutants, Chemical/*toxicity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    Probing primate morality (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Feb 16;271(5251):904.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8584925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Humans ; Macaca/*psychology ; *Morals ; Pan troglodytes/*psychology
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  • 85
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    The effect of social experience on serotonergic modulation of the escape circuit of crayfish (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-19
    Description: The neuromodulator serotonin has widespread effects in the nervous systems of many animals, often influencing aggression and dominance status. In crayfish, the effect of serotonin on the neural circuit for tailflip escape behavior was found to depend on the animal's social experience. Serotonin reversibly enhanced the response to sensory stimuli of the lateral giant (LG) tailflip command neuron in socially dominant crayfish, reversibly inhibited it in subordinate animals, and persistently enhanced it in socially isolated crayfish. Serotonin receptor agonists had opposing effects: A vertebrate serotonin type 1 receptor agonist inhibited the LG neurons in dominant and subordinate crayfish and had no effect in isolates, whereas a vertebrate serotonin type 2 receptor agonist enhanced the LG neurons' responses in all three types of crayfish. The LG neurons appear to have at least two populations of serotonin receptors that differ in efficacy in dominant, subordinate, and socially isolate crayfish.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yeh, S R -- Fricke, R A -- Edwards, D H -- R01 NS26457/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):366-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Georgia State University, Atlanta, GA 30302-4010, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553075" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astacoidea/*physiology ; Neurons/*physiology ; Receptors, Serotonin/*physiology ; Serotonin/pharmacology/*physiology ; Serotonin Receptor Agonists/pharmacology ; *Social Dominance ; *Social Isolation ; Synaptic Transmission/drug effects
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  • 86
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    Short-term plasticity of a thalamocortical pathway dynamically modulated by behavioral state (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-12
    Description: The neocortex receives information about the environment and the rest of the brain through pathways from the thalamus. These pathways have frequency-dependent properties that can strongly influence their effect on the neocortex. In 1943 Morison and Dempsey described "augmenting responses," a form of short-term plasticity in some thalamocortical pathways that is triggered by 8- to 15-hertz activation. Results from anesthetized rats showed that the augmenting response is initiated by pyramidal cells in layer V. The augmenting response was also observed in awake, unrestrained animals and was found to be dynamically modulated by their behavioral state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Castro-Alamancos, M A -- Connors, B W -- MH19118/MH/NIMH NIH HHS/ -- NS25983/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 12;272(5259):274-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8602513" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*physiology ; Electric Stimulation ; Motor Cortex/physiology ; Neural Pathways ; *Neuronal Plasticity ; Pyramidal Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Synapses/physiology ; Thalamic Nuclei/*physiology
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    Panel finds EMFs pose no threat (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):910.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966567" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Child ; Environmental Exposure/*adverse effects ; Europe ; *Health Status ; Humans ; Leukemia, Radiation-Induced/*etiology ; Meta-Analysis as Topic ; *Radiation ; Risk Factors ; United States
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  • 88
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    The cerebellum: a neuronal learning machine? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-24
    Description: Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibulo-ocular reflex suggests that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a special role in learning the timing of movement; and (iii) the cerebellar cortex guides learning in the deep nuclei, which may allow learning to be transferred from the cortex to the deep nuclei. Because many of the similarities in the data from the two systems typify general features of cerebellar organization, the cerebellar mechanisms of learning in these two systems may represent principles that apply to many motor systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raymond, J L -- Lisberger, S G -- Mauk, M D -- EY03878/EY/NEI NIH HHS/ -- EY10198/EY/NEI NIH HHS/ -- MH46904/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1996 May 24;272(5265):1126-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of California, San Francisco, 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blinking/physiology ; Cerebellar Cortex/anatomy & histology/physiology ; Cerebellar Nuclei/anatomy & histology/physiology ; Cerebellum/anatomy & histology/*physiology ; Conditioning, Classical/physiology ; Eye Movements/physiology ; Eyelids/physiology ; Humans ; Learning/*physiology ; Neural Pathways ; Neuronal Plasticity ; Psychomotor Performance ; Reflex, Vestibulo-Ocular/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-26
    Description: Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of tyrosine kinase receptors, but all three bind with similar affinities to the neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain. In the absence of TrkA, NGF binding to p75NGR activated the transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells. This activation was not observed in Schwann cells isolated from mice that lacked p75NTR. The effect was selective for NGF; NF-kappa B was not activated by BDNF or NT-3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, B D -- Kaltschmidt, C -- Kaltschmidt, B -- Offenhauser, N -- Bohm-Matthaei, R -- Baeuerle, P A -- Barde, Y A -- New York, N.Y. -- Science. 1996 Apr 26;272(5261):542-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiochemistry, Max-Planck Institute for Psychiatry, Martinsried, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Brain-Derived Neurotrophic Factor ; Cell Nucleus/metabolism ; Cells, Cultured ; DNA/metabolism ; L Cells (Cell Line) ; Mice ; Molecular Sequence Data ; NF-kappa B/*metabolism ; Nerve Growth Factors/*metabolism/pharmacology ; Nerve Tissue Proteins/metabolism/pharmacology ; Neurotrophin 3 ; Proto-Oncogene Proteins/metabolism ; Rats ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, Nerve Growth Factor ; Receptor, trkA ; Receptors, Nerve Growth Factor/*metabolism ; Schwann Cells/*metabolism ; Signal Transduction/*physiology
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  • 90
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    Crystal structure of a group I ribozyme domain: principles of RNA packing (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-09-20
    Description: Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-step transesterification reaction. The catalytic core of these ribozymes is formed by two structural domains. The 2.8-angstrom crystal structure of one of these, the P4-P6 domain of the Tetrahymena thermophila intron, is described. In the 160-nucleotide domain, a sharp bend allows stacked helices of the conserved core to pack alongside helices of an adjacent region. Two specific long-range interactions clamp the two halves of the domain together: a two-Mg2+-coordinated adenosine-rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal loop. Metal- and ribose-mediated backbone contacts further stabilize the close side-by-side helical packing. The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cate, J H -- Gooding, A R -- Podell, E -- Zhou, K -- Golden, B L -- Kundrot, C E -- Cech, T R -- Doudna, J A -- 5T32GM08283-07/GM/NIGMS NIH HHS/ -- GM22778-21/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Sep 20;273(5282):1678-85.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. doudna@csb.yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8781224" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/chemistry ; Animals ; Base Composition ; Base Sequence ; Binding Sites ; Catalysis ; Crystallography, X-Ray ; Hydrogen Bonding ; *Introns ; Magnesium/chemistry ; Models, Molecular ; Molecular Sequence Data ; *Nucleic Acid Conformation ; Phosphates/chemistry ; Phylogeny ; RNA Splicing ; RNA, Catalytic/*chemistry/metabolism ; RNA, Protozoan/*chemistry/metabolism ; Ribose/chemistry ; Tetrahymena thermophila/genetics
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  • 91
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    Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-10
    Description: Cells deprived of serum mitogens will either undergo immediate cell cycle arrest or complete mitosis and arrest in the next cell cycle. The transition from mitogen dependence to mitogen independence occurs in the mid-to late G1 phase of the cell cycle and is called the restriction point. Murine Balb/c-3T3 fibroblasts deprived of serum mitogens accumulated the cyclin-dependent kinase (CDK) inhibitor p27Kip1. This was correlated with inactivation of essential G1 cyclin-CDK complexes and with cell cycle arrest in G1. The ability of specific mitogens to allow transit through the restriction point paralleled their ability to down-regulate p27, and antisense inhibition of p27 expression prevented cell cycle arrest in response to mitogen depletion. Therefore, p27 is an essential component of the pathway that connects mitogenic signals to the cell cycle at the restriction point.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coats, S -- Flanagan, W M -- Nourse, J -- Roberts, J M -- New York, N.Y. -- Science. 1996 May 10;272(5263):877-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629023" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Amino Acid Sequence ; Animals ; Base Sequence ; *Cell Cycle Proteins ; Culture Media ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinases/*antagonists & inhibitors/metabolism ; Cyclins/metabolism ; Down-Regulation ; Enzyme Inhibitors/*metabolism ; Epidermal Growth Factor/pharmacology ; *G1 Phase ; Gene Expression/drug effects ; Insulin-Like Growth Factor I/pharmacology ; Mice ; Microtubule-Associated Proteins/biosynthesis/genetics/*metabolism ; Mitogens/pharmacology ; Molecular Sequence Data ; Oligonucleotides, Antisense/pharmacology ; Platelet-Derived Growth Factor/pharmacology ; Proto-Oncogene Proteins c-sis ; *Tumor Suppressor Proteins
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    Panel backs animal testing alternatives (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1996 Jan 12;271(5246):135.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644785" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; *Animal Testing Alternatives ; *Animal Welfare ; Animals ; *Federal Government ; *Government ; Peer Review ; *Public Policy ; Reference Standards ; United States
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  • 93
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    Control of C. elegans larval development by neuronal expression of a TGF-beta homolog (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-22
    Description: The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ren, P -- Lim, C S -- Johnsen, R -- Albert, P S -- Pilgrim, D -- Riddle, D L -- HD11239/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1389-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA. riddle@biosci.mbp.missouri.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910282" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics/*growth & development/metabolism ; *Caenorhabditis elegans Proteins ; Genes, Helminth ; Genes, Reporter ; Green Fluorescent Proteins ; Helminth Proteins/chemistry/genetics/*physiology ; Humans ; Larva/growth & development/metabolism ; Ligands ; Luminescent Proteins/genetics ; Molecular Sequence Data ; Mutation ; Neurons, Afferent/*metabolism ; Phenotype ; Pheromones/pharmacology ; Temperature ; Transforming Growth Factor beta/chemistry/genetics/*physiology ; Transgenes
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    Loco cow logo (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zu Rhein, G M -- New York, N.Y. -- Science. 1996 Jun 14;272(5268):1573.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658126" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*pathology ; Cattle ; Encephalopathy, Bovine Spongiform/*pathology ; *Medical Illustration
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  • 95
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    Complexities in the treatment of autoimmune disease (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McFarland, H F -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2037-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroimmunology Branch, National Institutes of Health, Bethesda, MD 20892, USA. henrymcf@helix.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8984662" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/immunology ; Autoimmune Diseases/immunology/*therapy ; CD8-Positive T-Lymphocytes/*immunology ; Callithrix ; Cytokines/*immunology ; Diabetes Mellitus, Type 1/immunology/therapy ; Encephalomyelitis, Autoimmune, Experimental/immunology/therapy ; Humans ; Immune Tolerance ; Immunotherapy/*adverse effects ; Mice ; Myelin Proteins ; Myelin-Associated Glycoprotein/immunology ; Myelin-Oligodendrocyte Glycoprotein ; Ovalbumin/immunology ; Th1 Cells/*immunology ; Th2 Cells/*immunology
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    SIV data raise concern on oral-sex risk (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1421-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Transmission, Infectious ; Female ; HIV Infections/*transmission/virology ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Macaca mulatta ; Mouth/*virology ; Risk Factors ; *Sexual Behavior ; Sexual Behavior, Animal ; Simian Acquired Immunodeficiency Syndrome/*transmission/virology ; Tongue/virology
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  • 97
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    Amino acid racemization and the preservation of ancient DNA (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-10
    Description: The extent of racemization of aspartic acid, alanine, and leucine provides criteria for assessing whether ancient tissue samples contain endogenous DNA. In samples in which the D/L ratio of aspartic acid exceeds 0.08, ancient DNA sequences could not be retrieved. Paleontological finds from which DNA sequences purportedly millions of years old have been reported show extensive racemization, and the amino acids present are mainly contaminates. An exception is the amino acids in some insects preserved in amber.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poinar, H N -- Hoss, M -- Bada, J L -- Paabo, S -- New York, N.Y. -- Science. 1996 May 10;272(5263):864-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Munich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629020" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine/chemistry ; *Amber/chemistry ; Amino Acids/*chemistry ; Animals ; Aspartic Acid/chemistry ; DNA/*analysis/chemistry ; *Fossils ; History, Ancient ; Humans ; Leucine/chemistry ; *Paleontology ; Stereoisomerism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    New mammal data challenge evolutionary pulse theory (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 1996 Jul 26;273(5274):431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8677437" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; *Antelopes ; *Biological Evolution ; *Climate ; Fossils ; *Hominidae ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 99
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    IVF project stirs debate over how to preserve pandas (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meiyue, Z -- New York, N.Y. -- Science. 1996 Jun 14;272(5268):1580-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658127" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild ; Animals, Zoo ; Breeding ; China ; Conservation of Natural Resources ; Female ; Fertilization in Vitro/*veterinary ; Pregnancy ; *Ursidae
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Structural evidence for functional domains in the rat hippocampus (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-07
    Description: The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Risold, P Y -- Swanson, L W -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1484-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles 90089-2520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Behavior, Animal ; *Brain Mapping ; Enkephalins/analysis ; Glutamate Decarboxylase/analysis ; Hippocampus/*anatomy & histology/*physiology ; Hypothalamus/anatomy & histology/physiology ; In Situ Hybridization ; Memory/physiology ; Neural Pathways ; Neuropeptides/analysis ; Pyramidal Cells/cytology/physiology ; Rats ; Septal Nuclei/*anatomy & histology/*physiology ; Somatostatin/analysis ; gamma-Aminobutyric Acid/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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