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  • Animals  (27,852)
  • Theorie
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  • 1
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-04-08
    Description: Das Verhältnis von klassischen und modernen Theorien der Macht wird gemeinhin kontradiktorisch gedacht: entweder aus dem Glauben, beide Theorien würden sich systematisch ausschließen, oder basierend auf der Annahme, die modernen Machttheorien à la Michel Foucault hätten die klassischen à la Thomas Hobbes abgelöst. Das Phänomen der Macht aus einem wechselseitigen Verhältnis beider Ansätze zueinander zu begreifen, ist bisher ein Desiderat in der Forschung. Der Band wirft einen neuen Blick auf die Macht, indem er Beiträge zur Vermittlung beider Ansätze versammelt. Nicht nur wissenschaftliche, sondern auch künstlerische Beiträge machen das Phänomen aus einer ganzheitlicheren Perspektive heraus zugänglich.
    Keywords: Macht ; Herrschaft ; Theorie ; Performative Philosophie ; Performance ; Politik ; Politische Philosophie ; Politische Theorie ; Politische Soziologie ; Politikwissenschaft ; Philosophie ; Power ; Power Relations ; Theory ; Performative Philosophy ; Politics ; Political Philosophy ; Political Theory ; Political Sociology ; Political Science ; Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: German
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  • 2
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    Beltz Juventa | Beltz Juventa
    Publication Date: 2024-04-08
    Description: Transfer zwischen Wissenschaft und Praxis kommt in komplexen Gesellschaften, die sich zunehmend auf Wissen stützen, ein besonderer Stellenwert zu. Dies greift der Band auf, indem unterschiedliche Auseinandersetzungen versammelt werden, die sich Transfer spezifisch aus den Feldern von Pädagogik und Erziehungswissenschaft widmen. Sie geben Einblicke in theoretische, empirische und praktische Verhältnisbestimmungen zwischen Forschung, Theorie, Handeln und Praxis.
    Keywords: Erziehungswissenschaft ; Bildung ; Pädagogik ; Forschung ; Studium ; Theorie ; Handeln ; Transfer ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy
    Language: German
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  • 3
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    transcript Verlag
    Publication Date: 2024-04-06
    Description: Die deutschen Gewerkschaften sind massiv von den Auswirkungen der Digitalisierung der Arbeitswelt betroffen. Ihre Organisations- und Durchsetzungsfähigkeit wird ebenso strapaziert wie ihr Anspruch auf eine möglichst umfassende Repräsentation der lohnabhängig Beschäftigten und Arbeitenden. Vor diesem Hintergrund diskutieren die Beiträger*innen die theoretischen Möglichkeiten und praktischen Erfahrungen mit der Digitalisierung von Gegenmacht aus gewerkschaftlicher und sozialwissenschaftlicher Perspektive. Dazu gehören u.a. Formen des Arbeitskampfes im digitalen Sektor und neue, widerständige Praktiken im Internet oder in der digitalen Infrastruktur von Unternehmen und Konzernen.
    Keywords: Gewerkschaft ; Digitalisierung ; Macht ; Gegenmacht ; Demokratie ; Solidarität ; Politischer Konflikt ; Aktivismus ; Theorie ; Arbeitskampf ; Betriebsrat ; Internet ; Infrastruktur ; Unternehmen ; Konzern ; Plattformkapitalismus ; Digitalökonomie ; Arbeit ; Politik ; Zivilgesellschaft ; Policy ; Arbeits- und Industriesoziologie ; Arbeitsökonomie ; Politikwissenschaft ; Labour Union ; Digitalization ; Power ; Democracy ; Solidarity ; Activism ; Theory ; Labour Struggle ; Works Council ; Infrastructure ; Work ; Politics ; Civil Society ; Sociology of Work and Industry ; Labour Economics ; Political Science ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPW Political activism / Political engagement ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour
    Language: German
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  • 4
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-04-02
    Description: Geschichte als nicht-linearen Verlauf aufzufassen heißt, historische Zusammenhänge in all ihrer Komplexität auszudrücken. Dabei stoßen wir mit gedruckten Texten an Grenzen. Christian Wachter zeigt: Digitaler Hypertext hingegen erweist sich als konstruktive Erweiterung für die Erkenntnisvermittlung - non-linear gedachte Zusammenhänge werden mit einem non-linearen Medium explizit repräsentiert. Entgegen einem netzwerkartigen Schreiben drängen sich multilinear angelegte und visualisierte Erzählpfade auf, die den narrativen und argumentativen Aufbau der Wissensangebote abbilden. Sie vermitteln dadurch epistemisch Wesentliches.
    Keywords: Hypertext ; Historiografie ; Theorie ; Elektronisches Publizieren ; E-Publishing ; Digitale Geschichtswissenschaft ; Kulturgeschichte ; Sprache ; Wissenschaft ; Geschichtstheorie ; Digital Humanities ; Digitale Medien ; Geschichtswissenschaft ; Historiography ; Theory ; Electronic Publishing ; Digital Historiography ; Cultural History ; Language ; Science ; Theory of History ; Digital Media ; History ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general::GPS Research methods: general
    Language: German
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  • 5
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    Beltz Juventa | Beltz Juventa
    Publication Date: 2024-04-07
    Description: Es gibt eine Vielzahl an zu Klassikern geronnenen Beschreibungen der Pädagogik als paradox bzw. Paradoxien bearbeitend (z.B. Freiheit/Zwang). Im Sammelband wird in diesem bzw. dieses Verständnis analysiert, relativiert, justiert und erweitert. Dabei konzentrieren sich die Studien auf pädagogische Theorien, Semantiken, Interaktionen, Professionen und Organisationen. In diesen Kontexten wird den Fragen nachgegangen, inwiefern die Pädagogik in ihren Operationsweisen Paradoxien erzeugt, mitführt und bearbeitet und welche Effekte das zeitigt.
    Keywords: Erziehungswissenschaft ; Bildung ; Erziehung ; Geschichte ; Theorie ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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  • 6
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-04-11
    Description: Die Medienwissenschaft operiert häufig mit gleichermaßen überstrapazierten wie langlebigen Analogiekonstruktionen. Verführt durch das Kopplungspotenzial von Analogien verschenkt sie damit Teile ihres genuin theoretischen Potenzials und riskiert mitunter fatale Folgekosten. Melina Kirchartz nimmt die noch immer unterschätzte konstitutive Rolle von prominenten Analogien wie der zwischen Mensch und Maschine für die Genese von Theorien unter die Lupe. Der Blick auf die theoretische Struktur der Medienwissenschaft selbst fördert ein argumentationsstrategisches Phänomen zutage, das es in das Bewusstsein geisteswissenschaftlicher Diskurse zu rücken gilt.
    Keywords: Analogie ; Theorie ; Wissenschaft ; Medientheorie ; Mensch ; Maschine ; Technik ; Mechanik ; Kybernetik ; Extensionsthese ; Medien ; Medienphilosophie ; Technikphilosophie ; Wissenschaftsphilosophie ; Medienwissenschaft ; Analogy ; Theory ; Science ; Media Theory ; Human ; Machine ; Technology ; Cybernetics ; Media ; Media Philosophy ; Philosophy of Technology ; Philosophy of Science ; Media Studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy
    Language: German
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  • 7
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    Beltz Juventa | Beltz Juventa
    Publication Date: 2024-04-06
    Description: Der Band unternimmt vor dem Hintergrund von Diskussionen um globale und postkoloniale Anliegen den Versuch, das Verständnis von Bildung und Schule neu zu justieren. Dies geschieht einerseits durch grundlagentheoretische Orientierungen, andererseits mit Hilfe von interkulturell-vergleichenden Fragestellungen durch die Auseinandersetzung mit aktuellen Herausforderungen. Dabei werden auch Konstellationen in den USA und Kanada beleuchtet. Die Beiträge bieten so wichtige Impulse sowohl zur Schulpädagogik als auch zur Allgemeinen Pädagogik.
    Keywords: Erziehungswissenschaft ; Bildung ; Erziehung ; Globalisierung ; Theorie ; Interkulturalität ; thema EDItEUR::J Society and Social Sciences::JN Education::JNA Philosophy and theory of education
    Language: German
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  • 8
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-03-22
    Description: Der Band möchte der Debatte um feministische Theorie neue Impulse geben, vor allem in der Philosophie. »Geschlecht« wird hier zwar ähnlich wie in den Naturwissenschaften noch immer weitgehend ausgeschlossen oder marginalisiert. Stellt man diesen Begriff aber ins Zentrum des Denkens, kann er neue Perspektiven auf grundlegende philosophische Probleme öffnen: auf Vernunft, Macht, Handeln, Gerechtigkeit, Demokratie. Die Texte zur politischen Theorie, Ethik, Anthropologie und Metaphilosophie, die der Band vereint, wollen in diesem Sinne das kritische Potenzial der Gender Studies für die Philosophie nutzen.
    Keywords: Gender ; Philosophie ; Queer ; Theorie ; Feminismus ; Intersektionalität ; Politikwissenschaft ; Anthropologie ; Kritische Theorie ; Diskursanalyse ; Sexuelle Differenz ; Diversity ; Geschlechterforschung ; Geschlecht ; Gender Studies ; Kulturwissenschaft ; Philosophy ; Political Science ; Critical Theory ; Cultural Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::H Humanities::HP Philosophy
    Language: German
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  • 9
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    transcript Verlag
    Publication Date: 2024-04-08
    Description: Nicht erst seit dem Aufkommen des Begriffs der »Cancel Culture« scheint es, als könne man schlicht nicht mehr miteinander reden. Die unterschiedlichen Konzeptionen von Ziel und Methode, also von der Strategie gesellschaftlicher Auseinandersetzungen, variieren so stark, dass sie schlicht nicht mehr kommensurabel sind. Diese Situation lässt sich als das Resultat einer langen Geschichte strategischer Entwürfe und Gegenentwürfe begreifen. Christopher Jakob Rudoll gibt anhand der Beispiele von Marxismus, Katholizismus und Feminismus einen systematischen Überblick über Debattenkulturen in Theorie und Praxis seit den 1920er-Jahren - und hilft somit, die aktuelle Sprachlosigkeit besser zu verstehen.
    Keywords: Kultur ; Auseinandersetzung ; Gesellschaft ; Theorie ; Debatte ; Marxismus ; Feminismus ; Katholizismus ; Sprache ; Kulturgeschichte ; Sozialphilosophie ; Kulturtheorie ; Kulturphilosophie ; Sprachphilosophie ; Philosophie ; Culture ; Society ; Theory ; Debate ; Marxism ; Feminism ; Catholicism ; Language ; Cultural History ; Social Philosophy ; Cultural Theory ; Philosophy of Culture ; Philosophy of Language ; Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: German
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  • 10
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    transcript Verlag | transcript Verlag
    Publication Date: 2023-11-17
    Description: In der Wissenschaft sind Erkenntnisziele, aber auch ein spezieller Weltaufschluss angelegt. Diesen zu vermitteln, ist Aufgabe der Wissenschaftsdidaktik. Was aber bedeutet es, Wissenschaft institutionell zu einem Gegenstand des Lehrens und Lernens zu machen? Die Beitragenden des Bandes liefern disziplinenübergreifende Antworten auf diese Frage und beleuchten Wissenschaftsdidaktik aus empirischer, theoretischer, konzeptioneller sowie praktisch-reflexiver Perspektive. Hochschullehrende sowie praktisch und forschend tätige Personen finden hier Zugang zur Wissenschaftsdidaktik und ihren innovativen Erkenntnispotentialen.
    Keywords: Hochschulbildung ; Wissenschaftsdidaktik ; Fachdidaktik ; Experiment ; Hermeneutik ; Methodologie ; Bildung ; Wissenschaft ; Universität ; Forschung ; Theorie ; Empirie ; Reflexion ; Praxis ; Bildungsforschung ; Bildungssoziologie ; Wissenschaftssoziologie ; Pädagogik ; University Education ; Science Didactics ; Subject Didactics ; Hermeneutics ; Methodology ; Education ; Science ; University ; Research ; Theory ; Empirical Research ; Practice ; Educational Research ; Sociology of Education ; Sociology of Science ; Pedagogy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMN Universities ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: German
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  • 11
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    Springer Nature | Springer Fachmedien Wiesbaden
    Publication Date: 2023-11-16
    Description: Das vorliegende Open-Access-Buch leistet einen zusammenhängenden theoretischen, methodischen und empirischen Beitrag zum Verständnis von Informationsverarbeitung in Gruppen. Menschen nutzen und verarbeiten Medieninhalte häufig gemeinsam. Trotzdem gibt es erst wenig und vornehmlich auf die Individualebene fokussierte Forschung zu kollektiver Medienrezeption bzw. kollektiver Informationsverarbeitung im Allgemeinen. Als theoretischer Beitrag wird das Model of Collective Information Processing (MCIP) entwickelt. Es verknüpft Erkenntnisse zu Gruppenprozessen mit Erkenntnissen zu individueller Informationsverarbeitung und unterscheidet zwischen verschiedenen kollektiven Verarbeitungsmodi. Anschließend wird als methodischer Beitrag ein standardisiertes Befragungsinstrument ausgearbeitet, das von Kleingruppen beantwortet werden kann. Dieses wird im Rahmen eines Mixed-Methods-Designs mithilfe qualitativer Beobachtungen und Gruppendiskussionen getestet, validiert und weiterentwickelt. Als zentraler empirischer Beitrag wird schließlich eine Onlinebefragung von n = 182 natürlichen Kleingruppen zu den Einflussfaktoren, Eigenschaften und Auswirkungen kollektiver Medienrezeption durchgeführt. Damit versucht die vorliegende Arbeit nicht nur unmittelbar Wissen über Informationsverarbeitung in Gruppen zu generieren, sondern auch mittelbar zu mehr Gruppenforschung zu inspirieren und motivieren.
    Keywords: Soziale Identität ; Theorie ; Kleingruppen ; Gruppen ; kollektive Informationsverarbeitung ; Interpersonale Kommunikation ; Medienwirkungen ; Gruppenbefragung ; Methode ; Anschlusskommunikation ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies
    Language: German
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  • 12
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    University of Calgary Press
    Publication Date: 2022-07-19
    Description: How have our interactions with animals shaped Calgary? What can we do to ensure that humans and animals in the city continue to co-exist, and even flourish together? This wide-ranging book explores the ways that animals inhabit our city, our lives and our imaginations. Essays from animal historians, wildlife specialists, artists and writers address key issues such as human-wildlife interactions, livestock in the city, and animal performers at the Calgary Stampede. Contributions from some of Calgary's iconic arts institutions, including One Yellow Rabbit Performance Theatre, Decidedly Jazz Danceworks, and the Glenbow Museum, demonstrate how animals continue to be a source of inspiration and exploration for fashion, art, dance, and theatre. The full-colour volume is beautifully illustrated throughout with archival images, wildlife photography, documentary and production stills, and original artwork. Calgary: City of Animals is published in co-operation with the Calgary Institute for the Humanities.
    Keywords: Nature ; Animals ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFZ Animals & society
    Language: English
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  • 13
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    transcript Verlag | transcript Verlag
    Publication Date: 2022-09-06
    Description: In den jüngeren Historisierungen der sogenannten »Theorie« der Kultur- und Literaturwissenschaft sind zwei Einordnungen dominant: Kritiker*innen haben das vermeintlich postmoderne Denken für ein ominöses »postfaktisches Zeitalter« verantwortlich gemacht, der Postmoderne eher verbundene Forscher*innen haben es in Form der Generationengeschichte thematisiert. Beiden Herangehensweisen gemeinsam ist das Moment des Rückblicks und der Verabschiedung. Die Beiträger*innen des Bandes nehmen diese jüngeren Bezugnahmen auf den Begriff der Postmoderne kritisch in den Blick und eruieren neben den Historisierungstendenzen auch neue Ansatzmöglichkeiten theoretischer Paradigmen in den Geistes- und Kulturwissenschaften.
    Keywords: Literatur ; Kultur ; Theorie ; Philosophie ; Medien ; Postmoderne ; Historisierung ; Kulturgeschichte ; Wissenschaft ; Kulturtheorie ; Poststrukturalismus ; Kulturwissenschaft ; Literature ; Culture ; Theory ; Philosophy ; Media ; Postmodernism ; Historization ; Cultural History ; Science ; Cultural Theory ; Post-structuralism ; Cultural Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; bic Book Industry Communication::H Humanities::HB History::HBT History: specific events & topics::HBTB Social & cultural history
    Language: German
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  • 14
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    University of Calgary Press
    Publication Date: 2022-07-19
    Description: Animal Metropolis brings a Canadian perspective to the growing field of animal history, ranging across species and cities, from the beavers who engineered Stanley Park to the carthorses who shaped the city of Montreal. Some essays consider animals as spectacle: orca captivity in Vancouver, polar bear tourism in Churchill, Manitoba, fish on display in the Dominion Fisheries Museum, and the racialized memory of Jumbo the elephant in St. Thomas, Ontario. Others examine the bodily intimacies of shared urban spaces: the regulation of rabid dogs in Banff, the maternal politics of pure milk in Hamilton and the circulation of tetanus bacilli from horse to human in Toronto. Another considers the marginalization of women in Canada’s animal welfare movement. The authors collectively push forward from a historiography that features nonhuman animals as objects within human-centered inquiries to a historiography that considers the eclectic contacts, exchanges, and cohabitation of human and nonhuman animals. With contributions by: Kristoffer Archibald, Jason Colby, George Colpitts, Joanna Dean, Carla Hustak, Darcy Ingram, Sean Kheraj, William Knight, Sherry Olson, Rachel Poliquin, and Christabelle Sethna
    Keywords: Animals ; Anthropology ; Environmental Science ; History ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::H Humanities::HB History ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFZ Animals & society
    Language: English
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  • 15
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-23
    Description: Can society mitigate hermeneutical injustice towards persons with learning disabilities? How do European theatres meet this challenge? How can artists with learning disabilities «have a voice»? The present volume searches for answers to these questions in theoretical approaches and in interviews with stage directors.
    Keywords: beeinträchtigte ; Cultural Studies ; Disabilities ; Disability Studies ; europäischen ; European ; GemeinsamTogether ; Hartwig ; Hermeneutics ; Inclusive Theatres ; Kognitiv ; Learning ; Menschen ; Mitarbeit ; Pereyra ; Practice ; PraxisPeople ; Soledad ; Susanne ; Theatern ; Theatre Studies ; Theatres ; Theorie ; Theory ; thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: English , German
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  • 16
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    KIT Scientific Publishing
    Publication Date: 2024-04-05
    Description: „Denkräume“ und „Denkbewegungen“ sind Metaphernfelder, die häufig in wissenschaftlichen Diskussionen und in der Theoriebildung Verwendung finden, wenn beispielsweise von der nötigen „Verortung“ der Gedanken, oder auch von der Konstruktion von „Theoriegebäuden“ gesprochen wird. Die vorliegende Arbeit beschäftigt sich mit der Verwendung solcher Metaphern und der zugrunde liegenden Annahme, dass die „Bauweisen“ von Theorie und Wissen zunehmend ins Bewusstsein der Philosophen rücken. Ziel dieser Arbeit ist es, jenseits klassischer Raumtheorie diesen Bereich der sprachlichen Verfasstheit wissenschaftlicher Texte und der damit verknüpften Sprach- und Bildlogik zu untersuchen, um einen bislang wenig beobachteten Bereich der metatheoretischen Selbstbeobachtung und Selbstbeschreibung der Philosophie sichtbar zu machen und interdiskursive Zusammenhänge und Traditionslinien aufzuzeigen.
    Keywords: Raum ; Bewegung ; Denken ; Theorie ; Metapher ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: German
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  • 17
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    Berghahn Books | Berghahn Books
    Publication Date: 2023-02-02
    Description: Employing methodological perspectives from the fields of political geography, environmental studies, anthropology, and their cognate disciplines, this volume explores alternative logics of sentient landscapes as racist, xenophobic, and right-wing. While the field of sentient landscapes has gained critical attention, the literature rarely seems to question the intentionality of sentient landscapes, which are often romanticized as pure, good, and just, and perceived as protectors of those who are powerless, indigenous, and colonized. The book takes a new stance on sentient landscapes with the intention of dispelling the denial of “coevalness” represented by their scholarly romanticization.
    Keywords: Social Science ; Sociology ; Rural ; Nature ; Animals ; Social Science ; Anthropology ; Cultural & Social ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSF Rural communities ; bic Book Industry Communication::W Lifestyle, sport & leisure::WN Natural history::WNC Wildlife: general interest ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography
    Language: English
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  • 18
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-30
    Description: Auf den Märkten für medizinische Leistungen und in der Beziehung zwischen Arzt und Patient existieren Informationsasymmetrien in einer Vielzahl, wie sie in kaum einem anderen Bereich einer Ökonomie anzutreffen sind. In der Arbeit wird die beidseitige Informationsasymmetrie zwischen Arzt und Patient untersucht. Zum einen geschieht dies hinsichtlich des Einflusses von Änderungen der Vertragsparameter auf die medizinische Leistung und das Verhalten des Patienten. Zum anderen betrifft dies die Wahl der Versicherungs- und Vergütungsparameter. Ergänzend wird die Arzt-Patient-Beziehung mittels einer empirischen Analyse untersucht. In deren Mittelpunkt stehen die Determinanten der Gesundheitszufriedenheit des Patienten und dabei insbesondere die Inanspruchnahme medizinischer Leistungen.
    Keywords: Agent ; Anwendung ; Arzt ; Beziehung ; Empirie ; Gesundheitsnachfrage ; Kundenbetreuung ; Patient ; Patient ; Principal ; Schneider ; Theorie ; Verhältnis ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCK Behavioural economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVJ Health economics ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPR Medical insurance ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBS Medical sociology
    Language: German
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  • 19
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-24
    Description: In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.
    Keywords: Küppers ; Literatur ; Literaturkritik ; Literaturwissenschaft ; Russland ; Slavische Sprachwissenschaft ; Theorie ; Typischen ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: German
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  • 20
    Publication Date: 2024-04-05
    Description: ""Denkräume"" und ""Denkbewegungen"" sind Metaphernfelder, die häufig in wissenschaftlichen Diskussionen und in der Theoriebildung Verwendung finden, wenn beispielsweise von der nötigen ""Verortung"" der Gedanken, oder auch von der Konstruktion von ""Theoriegebäuden"" gesprochen wird.Ziel dieser Arbeit ist es, jenseits klassischer Raumtheorie diesen Bereich der sprachlichen Verfasstheit wissenschaftlicher Texte und der damit verknüpften Sprach- und Bildlogik zu untersuchen.
    Keywords: B1-5802 ; Raum ; Theorie ; Metapher ; Bewegung ; Denken ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: German
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  • 21
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-03-28
    Description: Wie werden Natur und Tiere durch die Multispezies-Ethnographie inklusiv in Forschungsprojekte integriert? Katharina Ameli fokussiert die inter- und multidisziplinäre Zusammenarbeit. Aus einer Untersuchung der Schnittstellen zwischen gesellschafts- und naturwissenschaftlich orientierten Fachdisziplinen ergibt sich eine komplexe Betrachtung von Natur, Mensch und Tier. Die Einblicke in Interdependenzen unterschiedlicher Fachdisziplinen verdeutlichen den Bedarf an einer Multispezies-Ethnographie zur Analyse von MenschenTiereNaturenKulturen.
    Keywords: Natur ; Mensch ; Tiere ; Naturverständnis ; Interdisziplinarität ; Qualitative Forschung ; Kultur ; Ethnographie ; Umwelt ; Tier ; Human-animal Studies ; Umweltsoziologie ; Kulturanthropologie ; Kultursoziologie ; Kulturwissenschaft ; Nature ; Human ; Animals ; Understanding of Nature ; Interdisciplinarity ; Qualitative Research ; Culture ; Ethnography ; Environment ; Animal ; Environmental Sociology ; Cultural Anthropology ; Sociology of Culture ; Cultural Studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFU Animals and society ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNT Social impact of environmental issues ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: German
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  • 22
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: In der Auseinandersetzung um die Freisetzung und Kompensation von Arbeitskräften im Zuge des technischen Fortschritts wird seit den Schriften von David Ricardo und Adam Smith auf die Diffusion von Innovationen hingewiesen. Sie wird jedoch selten explizit in den Disput um technologische Arbeitslosigkeit einbezogen. Die systematische Berücksichtigung der Diffusion gehört daher zu den vernachlässigten Aspekten der Analyse technologischer Arbeitslosigkeit. Demgegenüber existiert seit den 50er Jahren des letzten Jahrhunderts eine Diffusionstheorie, die sich mit den Determinanten der Ausbreitung von Innovationen beschäftigt. Der Autor setzt sich kritisch mit der Verbindung der makroökonomischen Debatte um die Beschäftigungswirkungen und der mikroökonomischen Analyse der Ausbreitung des technischen Fortschritts auseinander. Ziel der Arbeit ist es, zu einer Mikrofundierung der makroökonomischen Kompensations- und Freisetzungsdebatte beizutragen.
    Keywords: Arbeitslosigkeit ; Arbeitslosigkeit ; Beitrag ; Beschäftigung ; Beschäftigung ; Beschäftigungswirkung ; Diffusion ; Diffusion ; Diffusion (Wirtschaft) ; Erklärung ; Freisetzung ; Holwegler ; Innovation ; Innovation ; Kompensation ; ökonomische ; Strukturelle Arbeitslosigkeit ; Technischer Fortschritt ; Technologiediffusion ; technologischer ; Theorie ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCF Labour economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCG Economic growth ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCS Economic systems & structures
    Language: German
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  • 23
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    transcript Verlag
    Publication Date: 2024-03-23
    Description: Der US-amerikanische Architekturdiskurs der 1990er Jahre ist entscheidend von den Theorien Gilles Deleuzes geprägt. Die Aneignung seiner philosophischen Konzepte und jener, die er gemeinsam mit Félix Guattari entwickelt hat, findet vor allem innerhalb des architekturtheoretischen Netzwerks der »Anyone Corporation« statt: In ihren Diskursen wimmelt es von glatten Räumen, organlosen Körpern, Rhizomen, Falten, abstrakten Maschinen und Diagrammen. Frederike Lausch zeigt auf, wie sich die »Anyone Corporation« durch die Bezugnahme auf Deleuze als intellektuelle Elite der Architekturdisziplin inszeniert und wie im Zuge der Entpolitisierung seiner Theorien die »Post-Criticality«-Bewegungen entstehen.
    Keywords: Architektur ; Philosophie ; 1990er Jahre ; USA ; Post-Criticality ; Gilles Deleuze ; Félix Guattari ; Raum ; Körper ; Rhizom ; Theorie ; Kultur ; Kulturphilosophie ; Poststrukturalismus ; Architecture ; Philosophy ; 1990s ; Space ; Body ; Theory ; Culture ; Philosophy of Culture ; Post-structuralism ; thema EDItEUR::A The Arts::AM Architecture ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: German
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  • 24
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    University Press of Colorado | University Press of Colorado
    Publication Date: 2024-04-02
    Description: Animals and Inequality in the Ancient World explores the current trends in the social archaeology of human-animal relationships, focusing on the ways in which animals are used to structure, create, support, and even deconstruct social inequalities. The authors provide a global range of case studies from both New and Old World archaeology—royal Aztec dog burial, the monumental horse tombs of Central Asia, and the ceremonial macaw cages of ancient Mexico among them. They explore the complex relationships between people and animals in social, economic, political, and ritual contexts, incorporating animal remains from archaeological sites with artifacts, texts, and iconography to develop their interpretations. Animals and Inequality in the Ancient World presents new data and interpretations that reveal the role of animals, their products, and their symbolism in structuring social inequalities in the ancient world. The volume will be of interest to archaeologists, especially zooarchaeologists, and classical scholars of pre-modern civilizations and societies.  Contributors: Alejandra Aguirre Molina, Benjamin S. Arbuckle, Levent Atici, Douglas V. Campana, Roderick Campbell, Ximena Chá­vez Balderas, Pam J. Crabtree, Susan D. deFrance, Kitty F. Emery, Abigail Holeman, H. Edwin Jackson, Leonardo López Lujá­n, Michael MacKinnon, Arkadiusz Marciniak, Sue Ann McCarty, Neil L. Norman, Gilberto Perez, Bernardo Rodriguez, William A. Saturno, Ashley E. Sharpe, Nawa Sugiyama, Charlotte K. Sunseri, Naomi Sykes, Fabiola Torres, Raul Valadez, Norma Valentin Maldonado, Adam S. Watson, Joshua Wright, Belem Zuniga-Arelleno
    Keywords: History ; Ancient ; Social Science ; Archaeology ; Nature ; Animals ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WN Nature and the natural world: general interest::WNC Wildlife: general interest
    Language: English
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  • 25
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-24
    Description: Die vorliegende Arbeit will untersuchen, ob es im Wortvorratssystem der russischen Sprache lexikalische Einheiten gibt, die mit Hilfe von Nullsuffixen gebildet wurden. Diese nullsuffigierten lexikalischen Einheiten sollen in ihrer Gesamtheit beschrieben werden.
    Keywords: Affixode ; Lexikalisierung ; Menge ; Neutralisation ; Nullsuffigierung ; Nullsuffix ; Russische ; Russischen ; synkretistische Endung ; Theorie ; Transposition ; Verbeeck ; Wortbildung ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 26
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: Der dynamischen Analyse der längerfristigen Wirkungen expansiver Fiskalpolitik ist ein nachfrageorientiertes Modell mit staatlicher Budgetbeschränkung (Blinder-Solow-Modell) zugrundegelegt. Es wird gezeigt, dass ein längerfristiges Gleichgewicht mit ausgeglichenem öffentlichen Budget bei reiner Kredit-(Bond-)Finanzierung öffentlicher Defizite nicht bzw. nur unter unrealistischen Annahmen erreicht wird. Werden in der Finanzierungsphase Massnahmen zur Konsolidierung des öffentlichen Haushalts durchgeführt, wirken - je nach Finanzierungsart - ursprünglich expansiv angelegte fiskalpolitische Massnahmen längerfristig möglicherweise sogar kontraktiv.
    Keywords: «expansiver» ; Analyse ; ausgewählter ; Bartsch ; Berücksichtigung ; besonderer ; Budgetbeschränkung ; Defizitfinanzierung ; dynamische ; Eine ; Fiskalpolitik ; längerfristigen ; Möglichkeiten ; öffentlichen ; staatlichen ; Theorie ; unter ; Wirkungen ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy
    Language: German
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  • 27
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-29
    Description: Die Vertreter eines konstitutionellen Steuerreformansatzes lehnen die Reformempfehlungen der Theorie der optimalen Besteuerung (OT) mit dem Hinweis auf die mangelhafte Berücksichtigung politisch-ökonomischer Zusammenhänge ab. Sie befürchten, dass die Effizienzregeln der OT in der Hand eines Steuerstaates zur perfekten Ausbeutung der Steuerzahler missbraucht werden könnten. Vor dem Hintergrund konzeptioneller Defizite der modernen, normativen Steuertheorie werden jene Faktoren untersucht, die bei der Durchsetzung rationaler Steuerreformen von ausschlaggebender Bedeutung sind. Die positive Analyse des demokratischen Steuerreformprozesses belegt, dass eine effiziente und gerechte Besteuerung der Zensiten nur durch eine Steuerverfassung gewährleistet werden kann. Der Autor entwickelt u.a. eine Verfassungsregel, die eine norminkonsistente Vergabe von Steuerprivilegien verhindern soll.
    Keywords: Demokratie ; Mann ; Politik ; Steuerreform ; Theorie ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNC Company, commercial and competition law: general::LNCB Commercial law
    Language: German
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  • 28
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-29
    Description: Die ökonomische Föderalismustheorie auf der Basis der Arbeiten von Musgrave und Oates ordnet Verteilungskompetenzen grundsätzlich der Zentralebene zu. Unter Berufung auf diese Arbeiten wird auch die Ausweitung der Verteilungskompetenzen der EG gefordert. An diesen traditionellen Föderalismusmodellen wird in der vorliegenden Arbeit Kritik geübt und folgend ein wohlfahrtstheoretisches Modell entwickelt, in dem jede Ebene Verteilungskompetenzen in bezug auf die direkt untergeordneten Wirtschaftseinheiten besitzt. Mit Blick auf die konkreten Fragen der Verteilungspolitik in der EG läßt sich daraus der Schluß ziehen, daß die EG nur interregional verteilungspolitisch tätig werden sollte; interpersonelle Verteilungspolitik fiele dementsprechend ausschließlich in die Kompetenz der Mitgliedstaaten.
    Keywords: aufgrund ; Eine ; einer ; Europäischen ; Föderalismus ; Fortentwicklung ; Gemeinschaft ; Kompetenzen ; Malchow ; ökonomischen ; Theorie ; Untersuchung ; VERTEILUNGSPOLIT ; verteilungspolitischer ; Zuordnung ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCB Macroeconomics::KCBM Monetary economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy
    Language: German
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  • 29
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: This book develops a new theoretical approach to the explanation of systemic financial crises in industrial and emerging market countries. In contrast to standard models, the present 〈I〉cyclical〈/I〉 approach is consistent with the following three stylized facts. Firstly, systemic financial crises are a recurrent phenomenon generally accompanied by excessive boom-bust cycles. Secondly, the frequency of financial crisis cycles is very irregular. Thirdly, most financial crisis cycles are initiated by positive shocks to profit expectations which induce an unsustainable build-up of financial fragility driven by 〈I〉irrational exuberance〈/I〉. The present approach is based on a sophisticated balancesheet structure with many assets, as well as on an expectation formation scheme which combines the rational expectations hypothesis with Keynes’ 〈I〉Beauty Contest Theory〈/I〉.
    Keywords: Approach ; Beauty Contest Theory ; Crises ; Cyclical ; Explaining ; Financial ; Financial Crises ; Financial Stability ; Long-Run Rationality ; Radke ; Theorie ; Währungskrise ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCB Macroeconomics::KCBM Monetary economics
    Language: English
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  • 30
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: Der demografische Wandel diente in der ersten Dekade des 21. Jahrhunderts als Hauptgrund für die in Deutschland erfolgten Reformen im Bereich der Sozialversicherung, besonders der Alterssicherung. Die damit verbundenen institutionellen Veränderungen werden in einem Überblick über die Genese und die aktuelle Organisation der deutschen Alterssicherung umfassend und zugleich kompakt dargestellt. Anschließend geht es um die Frage, ob die erfolgten Reformen dem aktuellen Stand der Forschung gerecht werden. Dabei wird besonders auf die Rolle von Unsicherheit eingegangen, die in früheren Modellen nicht und damit im Prozess der politischen Beratung kaum berücksichtigt wurde. Schließlich bietet die Arbeit mit einer umfassenden empirischen Bestandsaufnahme erstmals einen Überblick zum Altersvorsorgestatus im Drei-Schichten-Modell. Dieser wurde mit einem innovativen Ansatz der Datenkombination ermittelt.
    Keywords: Alterssicherung ; Aspekte ; Berücksichtigung ; Bestandsaufnahme ; Deutschland ; Drei ; Drei-Säulen-Modell der Alterssicherung ; Eine ; Empirie ; Finanzierungsverfahren ; Kapitaldeckung ; Modells ; regionaler ; Schichten ; Schoder ; Theorie ; Umlageverfahren ; unter ; Versorgungswegen ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCR Welfare economics
    Language: German
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  • 31
    Publication Date: 2024-04-05
    Description: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
    Keywords: RC321-571 ; Q1-390 ; South America ; Multicenter research ; Neurodegenerative Diseases ; Neurosciences ; Public Health ; Animals ; Clinical Protocols ; Research ; Human Experimentation ; Dementia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 32
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: Das in der Wirtschaftspraxis zunehmend beobachtbare Phänomen der Koopetition, welches die Kooperation zwischen zueinander zugleich im Wettbewerb stehender Unternehmen beschreibt, ist aus wissenschaftlicher Perspektive empirisch und theoretisch unzureichend erfasst. Diese Arbeit untersucht daher das strategische Management dieser auf den ersten Blick paradox erscheinenden Interorganisationsbeziehungen am fokalen Beispiel eines Unternehmens der zivilen Flugzeugtriebwerksindustrie, welches im Zuge der kollektiven Erstellung komplexer Produkte (CoPS) durch tiefgreifende Kooperationspartnerschaften eng mit seinen Konkurrenten verbunden ist. Im Mittelpunkt der Analyse steht zum einen die Frage nach den spezifischen Gründen für das Auftreten und Eingehen von Koopetitionsbeziehungen, zum anderen die konkrete Ausgestaltung strategischen Handelns unter koopetitiven Verhältnissen und die Bewältigung des wettbewerblich-kooperativen Spannungsfelds durch die involvierten Unternehmen.
    Keywords: begründete ; Eine ; empirisch ; Flugzeugtriebwerke ; globale Interorganisationsnetzwerke ; Grounded Theory ; Herzog ; industriellen ; Kontext ; Koopetition ; Luftfahrt ; Luftfahrtindustrie ; Management ; Strategisches ; Theorie ; zivilen ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJU Organizational theory & behaviour
    Language: German
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  • 33
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-13
    Description: Obwohl die intermediären Finanzgewalten (Parafisci) seit den zwanziger Jahren an Bedeutung gewonnen haben, finden sie bislang wenig Berücksichtigung in der finanzwissenschaftlichen Literatur. Auf diese Lücke zielt das vorliegende Buch. Mit einem integrierten Ansatz, der die Ergebnisse einer dogmenhistorischen Betrachtungsweise der Staatstätigkeit aufgreift und ökonomische, gesellschaftliche und staatspolitische Kriterien miteinander verknüpft, werden die Parafisci sowohl gegenüber dem Staat als auch gegenüber den Privaten «zumindest qualitativ» abgegrenzt. Am Beispiel der Kirchen in der Bundesrepublik Deutschland wird ausführlich gezeigt, wie die theoretisch erarbeiteten Kriterien anzuwenden sind. Diese Ausführungen beinhalten eine konsequente, bislang nirgends dargestellte Diskussion des gesamten Tätigkeitsbereichs der Kirchen aus ökonomischem Blickwinkel.
    Keywords: Ansatz ; Finanzgewalten ; intermediären ; Kirchen ; ökonomischer ; Parafisci ; Saile ; Theorie ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCX Christian institutions & organizations ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LND Constitutional & administrative law::LNDA Citizenship & nationality law
    Language: German
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  • 34
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    transcript Verlag | transcript Verlag
    Publication Date: 2022-05-12
    Description: Wie lassen sich Subjektivierungsprozesse von »Migrationsanderen« rekonstruktiv erschließen und mit Begriffen der Butler'schen Subjekttheorie fassen? Am Beispiel biographischer Erzählungen vermittelt Nadine Rose Einsichten in Subjektbildungsprozesse von männlichen Jugendlichen aus Einwandererfamilien. Dabei werden implizite und explizite Anrufungen als »Andere« nicht nur als individuelle Herausforderungen gezeigt, sondern auch als Bildungsherausforderung für die Mehrheitsgesellschaft markiert. Die migrationspädagogische und bildungstheoretische Perspektive der Studie bietet dabei Einblicke in schulische und alltägliche Praxen der resignifizierenden Positionierung und Differenzierung.
    Keywords: Bildung ; Migration ; Biographie ; Empirie ; Theorie ; Subjektivierung ; Diskriminierung ; Anrufung ; Identifizierung ; Resignifizierung ; Judith Butler ; Soziale Ungleichheit ; Sozialpädagogik ; Bildungssoziologie ; Pädagogik ; Education ; Social Inequality ; Social Pedagogy ; Sociology of Education ; Pedagogy ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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  • 35
    Publication Date: 2024-03-24
    Description: The intention of the author was (...) to prove that the terminativity / aterminativity - as a "covert" category - is the semantic basis and generator of the Russian verbal aspect, thus de facto controlling the whole mechanism of the Russian aspect system - education , Meaning and use of the aspect. In order to largely objectify the profound semantic analysis required for this, we have decomposed the most general semantic properties of the verbs and the aspectual context into differential semantic features and arranged them in algorithmic form. Thus, we were able to follow the interaction of the general meanings of the aspect with the T / AT through the linguistic subsystems of aspect formation and the special aspect meanings. This algorithmic analysis as the main method of our investigation has u.E. In a convincing way many previously contentious questions have been solved, and common views have been confirmed or refuted.
    Description: Das Anliegen des Autors war es (...), den Nachweis zu erbringen, daß die Terminativität / Aterminativität - als "verdeckte" Kategorie - semantische Basis und Generator des russischen Verbalaspekts ist, also de facto den gesamten Mechanismus des russischen Aspektsystems steuert - Bildung, Bedeutung und Gebrauch des Aspekts. Um die dazu notwendige tiefgehende semantische Analyse weitgehend zu objektivieren, haben wir die allgemeinsten semantischen Eigenschäften der Verben und des aspektualen Kontextes in differentielle semantische Merkmale zerlegt und in algorithmischer Form angeordnet. Damit konnten wir das Zusammenwirken der Allgemeinbedeutungen des Aspekts mit der T/AT durch die sprachlichen Subsysteme der Aspektbildung und der speziellen Aspektbedeutungen verfolgen. Diese algorithmische Analyse als Hauptmethode unserer Untersuchung hat u.E. in überzeugender Weise viele bisher strittige Fragen einer Lösung zugeführt, gängige Auffassungen bestätigt oder widerlegt.
    Keywords: Aspekt ; Aspektbedeutung ; Aspektbildungssystem ; Aspektualität ; Aterminativität ; Beitrag ; Gegenwart ; Rolle ; russischen ; Russland ; Schlegel ; semantische Merkmale ; Slavische Sprachwissenschaft ; Sprache ; Terminativität ; Theorie ; Verbalaspekt ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 36
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-24
    Description: In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.
    Keywords: Andrej ; Ästhetik ; ästhetische ; Belyjs ; Bewusstseins ; Deppermann ; Jahrhundertwende ; Kreativität ; Krise ; Kultur ; Literaturwissenschaft ; Russland ; schöpferischen ; Symbolik ; Symbolisierung ; Theorie ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: German
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  • 37
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: drugs ; Behavior ; Memory tasks ; pre-clinical ; clinical ; Humans ; Animals ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 38
    Publication Date: 2022-05-13
    Description: Latente Variable, die beobachtbare Variable beeinflussen, selbst aber nicht direkt beobachtbar sind, entweder weil die beobachtbaren Größen mit Meßfehlern behaftet sind oder weil sie selbst direkt beobachtbaren und meßbaren Variablen nicht direkt entsprechen, wurden lange Zeit in der modernen Ökonometrie nicht beachtet. Besondere Bedeutung kommt der Verwendung von latenten Variablen zu, wenn die unternehmerischen Erwartungen im Rahmen eines simultanen Entscheidungsbildungsprozesses auf der Grundlage von quantitativem und qualitativem Datenmaterial modelliert werden. In der vorliegenden Arbeit wird die Theorie linearer latenter Kovarianzstrukturmodelle mit gemischtverteilten qualitativen und quantitativen Indikatoren und stetigen normalverteilten latenten Faktoren auf ein empirisches Preis- und Produktionsplanungsmodell mit Lagerhaltung übertragen. Im Vordergrund steht die Frage, welche Bedeutung die Existenz von Lager- und/oder Auftragsbeständen im Rahmen der intertemporalen Entscheidungsbildung besitzt, wenn insbesondere Unsicherheit in den Erwartungen über die künftige kurz- bzw. langfristige Entwicklung der innen- und außenwirtschaftlichen Nachfrage sowie der Kostenfaktoren besteht. Im Rahmen eines komparativ-statistischen und dynamischen latenten Strukturansatzes wird anschließend das Unternehmensverhalten von deutschen und französischen Unternehmen international vergleichend analysiert.
    Keywords: Anwendung ; deutschen ; Entwicklungen ; französischen ; Gewerbes ; Indikatorvariablen ; Kovarianzstrukturmodelle ; Krader ; Lageranpassungsverhaltens ; latenter ; linearer ; mikroempirisches ; Modell ; Neuere ; Preis ; Produktions ; qualitativen ; quantitativen ; Theorie ; Unternehmen ; Verarbeitenden ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCK Behavioural economics
    Language: German
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  • 39
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    Bielefeld University Press | transcript Verlag - Bielefeld University Press
    Publication Date: 2024-04-07
    Description: A part of sociology always wants to distance itself from any interference in the practice, and another part to influence society. In the first case, sociology sees itself as a science that looks at society from the outside. In the second case, she can not evade her affiliation with society. But what do these supposedly contradictory goals mean for sociologists and what does that say about the subject itself? Natalie Mevissen investigates the relationship of sociology to society with the help of hermeneutic interview analyzes and at the same time formulates conditions for a sociology of sociology in theory and methodology. She advocates a change of perspective: away from a problem discourse towards a perspective of the elective affinity of sociology with society.
    Description: Ein Teil der Soziologie will sich seit jeher von jeglicher Einmischung in die Praxis distanzieren, ein anderer Teil in die Gesellschaft hineinwirken. Im ersten Fall begreift die Soziologie sich als Wissenschaft, die von Außen auf die Gesellschaft schaut. Im zweiten Fall kann sie sich ihrer Zugehörigkeit zur Gesellschaft nicht entziehen. Was jedoch bedeuten diese vermeintlich widersprüchlichen Ziele für Soziolog*innen und was sagt das über das Fach selbst aus? Natalie Mevissen untersucht das Verhältnis der Soziologie zur Gesellschaft mit Hilfe hermeneutischer Interviewanalysen und formuliert zugleich Bedingungen für eine theoretisch wie methodologisch fundierte Wissenschaftssoziologie der Soziologie. Sie plädiert für einen Perspektivwechsel: weg von einem Problemdiskurs hin zu einer Perspektive der Wahlverwandtschaft der Soziologie mit der Gesellschaft.
    Keywords: Theory ; Practice ; Systems Theory ; Grounded Theory ; Documentary Method ; Science and Technology Studies ; Value Neutrality ; Hermeneutics ; Interview ; Society ; Science ; Sociology of Science ; Sociological Theory ; Sociology ; Theorie ; Praxis ; Systemtheorie ; Grounded Theory ; Dokumentarische Methode ; Science and Technology Studies ; Wertneutralität ; Hermeneutik ; Interview ; Gesellschaft ; Wissenschaft ; Wissenschaftssoziologie ; Soziologische Theorie ; Soziologie ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: German
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  • 40
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-29
    Description: Die Theorie des Rent-Seeking stellt einen Erklärungsansatz für das Zustandekommen staatlicher Aktivitäten in demokratischen Gesellschaftssystemen dar. Im Rahmen einer politisch-ökonomischen Analyse werden die allokativen und distributiven Konsequenzen des Wettbewerbs von Interessengruppen um gruppenspezifische Verteilungsvorteile untersucht. Dabei wird insbesondere auf die Interdependenz von distributiven Gruppeninteressen und politischem Entscheidungsverhalten eingegangen. Zur Lösung des Verteilungsdilemmas werden Reformvorschläge für den politischen Entscheidungsprozeß entwickelt, die eine Neuorientierung der Ordnungspolitik in demokratischen Staatswesen implizieren.
    Keywords: Demokratie ; Gruppeninteressen ; Interessengruppen ; Märtz ; Rent ; Seeking ; Theorie ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy
    Language: German
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  • 41
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-02
    Description: Demographische Alterung und technischer Fortschritt sind maßgebliche Ursachen für steigende Ausgaben im Gesundheitswesen. Reaktionen hierauf sind zusehends Beitragssatzsteigerungen und Kostendämpfungsmaßnahmen, weshalb der Markt für Gesundheitsgüter seine Wachstumspotenziale nicht voll auszuschöpfen vermag. In dieser Arbeit werden die positiven Aspekte der Gesundheit für die wirtschaftliche Entwicklung herausgearbeitet. Darüber hinaus wird das Zusammenspiel von Gesundheit und Bildung analysiert, da Bildung die Rolle eines zentralen Wachstumsmotors zukommt. Eine empirische Untersuchung gibt zudem Aufschluss über die wesentlichen Determinanten eines guten Gesundheitsverhaltens sowie einer guten Gesundheit als Voraussetzung für stetiges Wirtschaftswachstum.
    Keywords: Bildung ; Deutschland ; Empirie ; Gesundheit ; Gesundheitswesen ; Humankapital ; Humankapitalinvestitionen ; Kosten-Nutzen-Analyse ; Schneider ; Theorie ; Wirtschaftswachstum ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCG Economic growth ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCQ Health economics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues
    Language: German
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  • 42
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-13
    Description: Auch in der Theorie sind die Einkommens- und Vermögensbegriffe nicht immer von Erkenntnisprinzipien, sondern von politischen Absichten geprägt. Um dieses Fehlverständnis zu entlarven, bedürfen die Begriffe neuer theoretischer Grundlegung. Diese Zielsetzung verfolgt die vorliegende Studie. Dabei wird zwischen wirtschaftstheoretischen und steuerlichen Begriffen unterschieden und ferner eine strikte analytische Trennung des allokativen vom distributiven Bereich des Wirtschaftens eingehalten. Das Ergebnis ist die Forderung nach einer Personalbesteuerung gemäß dem Leistungsfähigkeitspostulat, die kategorisch abzuspalten ist von der Unternehmensbesteuerung gemäß der Ertragsfähigkeit.
    Keywords: Blick ; Eine ; Einkommens ; Hessler ; ihrer ; Kritik ; Leistungsfähigkeitstheorie ; Personalsteuern ; Politik ; Theorie ; Vermögensbegriffe ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCF Labour economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::K Economics, finance, business & management::KF Finance & accounting::KFF Finance::KFFD Public finance::KFFD1 Taxation ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law
    Language: German
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  • 43
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    transcript Verlag
    Publication Date: 2022-04-25
    Description: Die Prozesse kultureller Transformation in den gegenwärtigen Demokratien lassen sich mit den traditionellen Ansätzen der politischen Kulturforschung, bei denen vor allem politische Präferenzen untersucht werden, nicht mehr adäquat erfassen. Um die Wirksamkeit kultureller Dispositionen der Wahrnehmung und Beurteilung des Politischen sowie politischen Entscheidens und Handelns heute verstehen und analysieren zu können, bedarf es neuer Konzepte. Dieser Band versammelt Beiträge mit Befunden aktueller Forschung zu den politischen Dimensionen von Kultur und den kulturellen Dimensionen von Politik sowie mit innovativen theoretischen, programmatischen und methodischen Ansätzen.
    Keywords: Political Science ; Politische ; Kultur ; Medien ; Identität ; Narrative ; Populismus ; Politik ; Theorie ; Zivilgesellschaft ; Demokratie ; Soziale ; Bewegungen ; Politikwissenschaft ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory
    Language: German
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  • 44
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    Peter Lang International Academic Publishing Group
    Publication Date: 2022-05-12
    Description: Die Arbeit stellt zunächst das Interventionsverhalten der Notenbanken seit 1973 und die zugrundeliegenden Eingriffsgründe dar. Daran schließt sich eine umfangreiche theoretische und empirische Analyse der Interventionswirkungen an. Zielsetzung der Studie ist es, die bereits vorliegenden Untersuchungsergebnisse zu bündeln und zu einem Urteil darüber zu kommen, in welchen Situationen Interventionen wirksam und sinnvoll sein können. Dazu wird auch das Verhalten der Devisenmarktteilnehmer und die Effizienz des Devisenmarktes zusammenfassend betrachtet. Auf der Basis sowohl theoretischer Analyse als auch empirischer Beobachtungen kommt die Arbeit zu dem Schluß, daß Interventionen sehr kurzfristig Erwartungen der Devisenmarktteilnehmer beeinflussen können. Dieser Einfluß ist jedoch von vielen Faktoren, u.a. der Glaubwürdigkeit der Notenbank, abhängig.
    Keywords: Analyse ; Bedeutung ; Benesch ; Devisenmarktinterventionen ; Eine ; ihrer ; Praxis ; Theorie ; umfassende ; Wirkungsweisen ; wirtschaftspolitischen ; Zielsetzungen ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCB Macroeconomics::KCBM Monetary economics
    Language: German
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  • 45
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-24
    Description: 2012 wurde das Netzwerk-Projekt Landeskunde Nord ins Leben gerufen, dessen Ziel es ist, Forschung und Lehre zur Landeskunde des Deutschen als Fremdsprache, insbesondere in den nordischen Ländern, voranzutreiben. Das vorliegende Buch, Perspektive Nord, knüpft an den 2013 erschienenen Band Landeskunde Nord an und bietet Reflexionen wissenschaftstheoretischer, fachdidaktischer und inhaltlicher Aspekte, die für die Gestaltung der Landeskundelehre bzw. des Landeskundeunterrichts relevant sind. In ihrer Vielfalt sind die hier vorgelegten Konzepte und Ideen vor allem modernen kulturwissenschaftlichen Ansätzen verpflichtet, knüpfen an international geführte Diskussionen an und haben auch deshalb über die nordischen Länder hinaus Bedeutung. Dabei setzen die Autorinnen und Autoren auf autonomes und lebenslanges Lernen.
    Keywords: 2014 ; Becker ; Beiträge ; Deutsch als Fremdsprache ; Didaktik ; Konferenz ; Kulturwissenschaften ; Landeskunde ; modernen ; Netzwerks ; Nord ; Perspektive ; Praxis ; regionale Perspektive ; Stockholm ; Theorie ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CJ Language teaching and learning ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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  • 46
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    Reimer Verlag Berlin
    In:  Herausgeberexemplar | 99 A 20473
    Publication Date: 2021-03-29
    Description: Die städtebaulichen Probleme, die heute zu transponieren sind, stellen sich überwiegend als unübersichtlich und vielgestaltig — komplex — dar. Für die Elaborierung dieser Probleme soll eine Darstellung entwickelt werden, die für alle Beteiligten einfach nachvollzieh- und überprüfbar ist. Ziel wird es sein, bestehende Risikofaktoren in vereinfachender Darstellung komplexer städtebaulicher Situationen zu koordinieren und kommentieren. lm Rahmen dieser Arbeit sollen also komplexe städtebauliche Aufgaben so analysiert und charakterisiert werden, dass diese über die Grenzen der in dem Bereich der Stadtplanung und Stadtforschung tätigen Fachdisziplinen hinaus verstanden werden. Neuere Methoden für komplexe Planungsprobleme wurden bisher von den Praktikern wenig angenommen und folgende Argumente gegen die Anwendung dieser Planungsmethoden angeführt: 1) Tradierte Methoden geben dem Planer mehr individuelle Sicherheit und werden deshalb beibehalten, 2) implizite Aussagen der Planer machen die Lösung eines Planungsproblems für Planungsbeteiligte nicht exakt nachvollziehbar und bieten, je nach Diskussionslage, vielfältige Möglichkeiten der Interpretation durch den Planer, 3) es bestehen erhebliche Zweifel, ob sich alle erforderlichen Elemente der Untersuchungskategorien einer Lösung exakt erfassen und vor allem nachvollziehbar bewerten lassen, 4) die Planung wird durch Planungsmethoden für komplexe Probleme nicht einfacher, sondern diffiziler. Damit wächst der erforderliche wirtschaftliche Aufwand der Planer, 5) Methoden für komplexe Planungssysteme tragen zur Verunklärung auch scheinbar einfach erfassbarer Probleme bei. Das Ergebnis ist durch eine verwissenschaftlichte Darstellung manipulierbar.
    Description: thesis
    Description: DFG, SUB Göttingen
    Keywords: 910 ; Stadt- und Gemeindeplanung {Raumordnung und Raumplanung} ; Planung ; Theorie ; FID-GEO-DE-7
    Language: German
    Type: monograph_digi
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  • 47
    Publication Date: 2021-04-25
    Description: Niphargus is a speciose amphipod genus found in groundwater habitats across Europe. Three Niphargus species living in the sulphidic Frasassi caves in Italy harbour sulphur-oxidizing Thiothrix bacterial ectosymbionts. These three species are distantly related, implying that the ability to form ectosymbioses with Thiothrix may be common among Niphargus. Therefore, Niphargus-Thiothrix associations may also be found in sulphidic aquifers other than Frasassi. In this study, we examined this possibility by analysing niphargids of the genera Niphargus and Pontoniphargus collected from the partly sulphidic aquifers of the Southern Dobrogea region of Romania, which are accessible through springs, wells and Movile Cave. Molecular and morphological analyses revealed seven niphargid species in this region. Five of these species occurred occasionally or exclusively in sulphidic locations, whereas the remaining two were restricted to nonsulphidic areas. Thiothrix were detected by PCR on all seven Dobrogean niphargid species and observed using microscopy to be predominantly attached to their hosts' appendages. 16S rRNA gene sequences of the Thiothrix epibionts fell into two main clades, one of which (herein named T4) occurred solely on niphargids collected in sulphidic locations. The other Thiothrix clade was present on niphargids from both sulphidic and nonsulphidic areas and indistinguishable from the T3 ectosymbiont clade previously identified on Frasassi-dwelling Niphargus. Although niphargids from Frasassi and Southern Dobrogea are not closely related, the patterns of their association with Thiothrix are remarkably alike. The finding of similar Niphargus-Thiothrix associations in aquifers located 1200 km apart suggests that they may be widespread in European groundwater ecosystems.
    Keywords: amphipods; ecology; sulphide; symbiosis; systematics; taxonomy ; 551 ; Amphipoda ; Animals ; DNA, Bacterial ; Ecosystem ; Groundwater ; Molecular Sequence Data ; Phylogeny ; RNA, Ribosomal, 16S ; Romania ; Sequence Analysis, DNA ; Sulfur ; Symbiosis ; Thiothrix
    Language: English , English
    Type: article , publishedVersion
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  • 48
    Publication Date: 2016-01-20
    Description: The final identity and functional properties of a neuron are specified by terminal differentiation genes, which are controlled by specific motifs in compact regulatory regions. To determine how these sequences integrate inputs from transcription factors that specify cell types, we compared the regulatory mechanism of Drosophila Rhodopsin genes that are expressed in subsets of photoreceptors to that of phototransduction genes that are expressed broadly, in all photoreceptors. Both sets of genes share an 11-base pair (bp) activator motif. Broadly expressed genes contain a palindromic version that mediates expression in all photoreceptors. In contrast, each Rhodopsin exhibits characteristic single-bp substitutions that break the symmetry of the palindrome and generate activator or repressor motifs critical for restricting expression to photoreceptor subsets. Sensory neuron subtypes can therefore evolve through single-bp changes in short regulatory motifs, allowing the discrimination of a wide spectrum of stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rister, Jens -- Razzaq, Ansa -- Boodram, Pamela -- Desai, Nisha -- Tsanis, Cleopatra -- Chen, Hongtao -- Jukam, David -- Desplan, Claude -- K99EY023995/EY/NEI NIH HHS/ -- R01 EY13010/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1258-61. doi: 10.1126/science.aab3417.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003-6688, USA. ; Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003-6688, USA. cd38@nyu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785491" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Pairing ; Drosophila Proteins/*genetics ; Drosophila melanogaster/genetics/growth & development ; *Gene Expression Regulation, Developmental ; Mutation ; Photoreceptor Cells, Invertebrate/*physiology ; Promoter Regions, Genetic/*genetics ; Rhodopsin/*genetics ; Transcription Factors/metabolism ; Vision, Ocular/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Zhenwu -- Huang, Qifei -- Nie, Zhiqiang -- Yang, Yufei -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1176-7. doi: 10.1126/science.350.6265.1176-c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environmental Research Academy, North China Electric Power University, Beijing, 102206, China. ; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. huangqf@craes.org.cn. ; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785469" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Birds
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 50
    Publication Date: 2016-01-20
    Description: Migratory species depend on a suite of interconnected sites. Threats to unprotected links in these chains of sites are driving rapid population declines of migrants around the world, yet the extent to which different parts of the annual cycle are protected remains unknown. We show that just 9% of 1451 migratory birds are adequately covered by protected areas across all stages of their annual cycle, in comparison with 45% of nonmigratory birds. This discrepancy is driven by protected area placement that does not cover the full annual cycle of migratory species, indicating that global efforts toward coordinated conservation planning for migrants are yet to bear fruit. Better-targeted investment and enhanced coordination among countries are needed to conserve migratory species throughout their migratory cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Runge, Claire A -- Watson, James E M -- Butchart, Stuart H M -- Hanson, Jeffrey O -- Possingham, Hugh P -- Fuller, Richard A -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1255-8. doi: 10.1126/science.aac9180.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Geography, Planning and Environmental Management, University of Queensland, Brisbane, QLD, 4072, Australia. National Center for Ecological Analysis and Synthesis (NCEAS), University of California, Santa Barbara, Santa Barbara, CA 93101, USA. claire.runge@uqconnect.edu.au. ; School of Geography, Planning and Environmental Management, University of Queensland, Brisbane, QLD, 4072, Australia. Global Conservation Program, Wildlife Conservation Society, New York, NY, USA. ; BirdLife International, Wellbrook Court, Cambridge CB3 0NA, UK. ; School of Biological Sciences, University of Queensland, Brisbane, QLD 4072, Australia. ; School of Biological Sciences, University of Queensland, Brisbane, QLD 4072, Australia. Department of Life Sciences, Imperial College London, Silwood Park, Ascot, Berkshire SL5 7PY, England, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785490" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Birds ; Breeding ; *Conservation of Natural Resources ; Population Dynamics ; Seasons
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1188-90. doi: 10.1126/science.350.6265.1188.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785475" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/blood/genetics/*physiology ; Animals ; Biological Clocks/genetics/*physiology ; Biomarkers/blood/metabolism ; DNA/genetics ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Mice ; Rats ; Telomere Homeostasis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 52
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheid, Johannes F -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1175. doi: 10.1126/science.aad7133.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital, Boston, MA 02114, USA. The Rockefeller University, New York, NY 10021, USA. fscheid@partners.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785466" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/genetics/immunology/isolation & purification ; Antibodies, Neutralizing/genetics/*immunology/isolation & purification ; B-Lymphocytes/*immunology ; Cell Separation/methods ; HIV Antibodies/genetics/*immunology/isolation & purification ; HIV Infections/*blood ; Humans ; Immunologic Memory ; Mice ; env Gene Products, Human Immunodeficiency Virus/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 53
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurtley, Stella -- Roberts, Leslie -- Ray, L Bryan -- Purnell, Beverly A -- Ash, Caroline -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1180-1. doi: 10.1126/science.350.6265.1180.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785472" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*genetics ; Animals ; Health ; Humans ; Mitochondria/metabolism ; Stem Cells/physiology ; Telomere/*genetics ; *Telomere Homeostasis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ford, Adam T -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1175. doi: 10.1126/science.aad7134.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Biology at the University of Guelph, Guelph, Ontario, Canada. adamford@uoguelph.ca.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Wild ; Antelopes ; *Dogs ; Endangered Species ; *Food Chain ; *Grassland ; *Herbivory ; Humans ; Plants
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    Publication Date: 2016-01-20
    Description: Mitochondrial morphology is shaped by fusion and division of their membranes. Here, we found that adult myocardial function depends on balanced mitochondrial fusion and fission, maintained by processing of the dynamin-like guanosine triphosphatase OPA1 by the mitochondrial peptidases YME1L and OMA1. Cardiac-specific ablation of Yme1l in mice activated OMA1 and accelerated OPA1 proteolysis, which triggered mitochondrial fragmentation and altered cardiac metabolism. This caused dilated cardiomyopathy and heart failure. Cardiac function and mitochondrial morphology were rescued by Oma1 deletion, which prevented OPA1 cleavage. Feeding mice a high-fat diet or ablating Yme1l in skeletal muscle restored cardiac metabolism and preserved heart function without suppressing mitochondrial fragmentation. Thus, unprocessed OPA1 is sufficient to maintain heart function, OMA1 is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wai, Timothy -- Garcia-Prieto, Jaime -- Baker, Michael J -- Merkwirth, Carsten -- Benit, Paule -- Rustin, Pierre -- Ruperez, Francisco Javier -- Barbas, Coral -- Ibanez, Borja -- Langer, Thomas -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):aad0116. doi: 10.1126/science.aad0116.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. ; INSERM UMR 1141, Hopital Robert Debre, Paris, France. Universite Paris 7, Faculte de Medecine Denis Diderot, Paris, France. ; Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain. ; Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. Department of Cardiology, Instituto de Investigacion Sanitaria (IIS), Fundacion Jimenez Diaz Hospital, Madrid, Spain. thomas.langer@uni-koeln.de bibanez@cnic.es. ; Institute for Genetics, University of Cologne, 50674 Cologne, Germany. Max-Planck-Institute for Biology of Aging, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. thomas.langer@uni-koeln.de bibanez@cnic.es.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785494" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathy, Dilated/genetics/metabolism/pathology ; Diet, High-Fat ; Embryonic Development ; Female ; GTP Phosphohydrolases ; Gene Deletion ; Heart/embryology ; Heart Failure/genetics/*metabolism/pathology ; Male ; Metalloendopeptidases/genetics ; Metalloproteases/genetics/metabolism ; Mice ; Mice, Knockout ; Mitochondria, Heart/*metabolism/ultrastructure ; *Mitochondrial Degradation ; *Mitochondrial Dynamics ; Mitochondrial Proteins/genetics/metabolism ; Muscle, Skeletal/enzymology ; Myocardium/*metabolism/pathology ; Myocytes, Cardiac/enzymology/pathology ; Proteolysis
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: Mitochondria generate adenosine 5'-triphosphate (ATP) and are a source of potentially toxic reactive oxygen species (ROS). It has been suggested that the gradual mitochondrial dysfunction that is observed to accompany aging could in fact be causal to the aging process. Here we review findings that suggest that age-dependent mitochondrial dysfunction is not sufficient to limit life span. Furthermore, mitochondrial ROS are not always deleterious and can even stimulate pro-longevity pathways. Thus, mitochondrial dysfunction plays a complex role in regulating longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Ying -- Hekimi, Siegfried -- MOP-114891/Canadian Institutes of Health Research/Canada -- MOP-123295/Canadian Institutes of Health Research/Canada -- MOP-97869/Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1204-7. doi: 10.1126/science.aac4357.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada. ; Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada. siegfried.hekimi@mcgill.ca.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785479" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*metabolism ; Animals ; Caenorhabditis elegans Proteins/genetics ; Electron Transport/genetics ; Electron Transport Complex III/genetics ; Longevity/genetics/*physiology ; Mice ; Mice, Knockout ; Mitochondria/genetics/*metabolism ; Point Mutation ; Reactive Oxygen Species/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleary, Allison S -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1174-5. doi: 10.1126/science.aad7103.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pennsylvania State University College of Medicine, Hershey PA 17078, USA. acleary@hmc.psu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785463" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/genetics/metabolism/*pathology ; Clone Cells/metabolism/pathology ; Female ; Mammary Neoplasms, Experimental/genetics/metabolism/*pathology ; Mice ; Neoplasms, Basal Cell/genetics/metabolism/pathology ; Wnt1 Protein/genetics/*metabolism ; ras Proteins/genetics/metabolism
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  • 58
    Publication Date: 2016-01-20
    Description: Age is the greatest risk factor for nearly every major cause of mortality in developed nations. Despite this, most biomedical research focuses on individual disease processes without much consideration for the relationships between aging and disease. Recent discoveries in the field of geroscience, which aims to explain biological mechanisms of aging, have provided insights into molecular processes that underlie biological aging and, perhaps more importantly, potential interventions to delay aging and promote healthy longevity. Here we describe some of these advances, along with efforts to move geroscience from the bench to the clinic. We also propose that greater emphasis should be placed on research into basic aging processes, because interventions that slow aging will have a greater effect on quality of life compared with disease-specific approaches.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaeberlein, Matt -- Rabinovitch, Peter S -- Martin, George M -- P30AG013280/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Washington, Seattle, WA 98195, USA. kaeber@uw.edu. ; Department of Pathology, University of Washington, Seattle, WA 98195, USA. ; Department of Pathology, University of Washington, Seattle, WA 98195, USA. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785476" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Diet ; Exercise ; Geriatrics/*trends ; *Health ; Humans ; Mortality ; Preventive Medicine/*trends ; Risk Factors ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Translational Medical Research/trends
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1186-7. doi: 10.1126/science.350.6265.1186.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785474" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/genetics/physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; Caloric Restriction ; Death ; Humans ; Hydra/genetics/physiology ; Longevity/genetics/*physiology ; Mice ; Mutation ; Phosphatidylinositol 3-Kinases/genetics/physiology
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  • 60
    Publication Date: 2016-01-20
    Description: In developing hearts, changes in the cardiac metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohydrates to fatty acids. Mechanisms responsible for this mitochondrial plasticity are unknown. Here, we found that PINK1-Mfn2-Parkin-mediated mitophagy directs this metabolic transformation in mouse hearts. A mitofusin (Mfn) 2 mutant lacking PINK1 phosphorylation sites necessary for Parkin binding (Mfn2 AA) inhibited mitochondrial Parkin translocation, suppressing mitophagy without impairing mitochondrial fusion. Cardiac Parkin deletion or expression of Mfn2 AA from birth, but not after weaning, prevented postnatal mitochondrial maturation essential to survival. Five-week-old Mfn2 AA hearts retained a fetal mitochondrial transcriptional signature without normal increases in fatty acid metabolism and mitochondrial biogenesis genes. Myocardial fatty acylcarnitine levels and cardiomyocyte respiration induced by palmitoylcarnitine were concordantly depressed. Thus, instead of transcriptional reprogramming, fetal cardiomyocyte mitochondria undergo perinatal Parkin-mediated mitophagy and replacement by mature adult mitochondria. Mitophagic mitochondrial removal underlies developmental cardiomyocyte mitochondrial plasticity and metabolic transitioning of perinatal hearts.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747105/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747105/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, Guohua -- Song, Moshi -- Csordas, Gyorgy -- Kelly, Daniel P -- Matkovich, Scot J -- Dorn, Gerald W 2nd -- HL058493/HL/NHLBI NIH HHS/ -- HL108943/HL/NHLBI NIH HHS/ -- HL122124/HL/NHLBI NIH HHS/ -- HL128071/HL/NHLBI NIH HHS/ -- HL59888/HL/NHLBI NIH HHS/ -- R01 HL058493/HL/NHLBI NIH HHS/ -- R01 HL059888/HL/NHLBI NIH HHS/ -- R01 HL108943/HL/NHLBI NIH HHS/ -- R01 HL128071/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):aad2459. doi: 10.1126/science.aad2459. Epub 2015 Dec 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. ; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. ; Center for Metabolic Origins of Disease, Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA. ; Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. gdorn@dom.wustl.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cellular Reprogramming ; GTP Phosphohydrolases/genetics/metabolism ; Heart/*embryology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria, Heart/metabolism/*physiology/ultrastructure ; Mitochondrial Degradation/genetics/*physiology ; Mitochondrial Dynamics ; Myocardium/*metabolism/ultrastructure ; Myocytes, Cardiac/metabolism/ultrastructure ; Protein Kinases/metabolism ; Ubiquitin-Protein Ligases/genetics/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues. Recent research has focused on the ways that genetic mutations, epigenetic changes, and the extrinsic environmental milieu influence stem cell functionality over time. We describe each of these three factors, the ways in which they interact, and how these interactions decrease stem cell health over time. We are optimistic that a better understanding of these changes will uncover potential strategies to enhance stem cell function and increase tissue resiliency into old age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodell, Margaret A -- Rando, Thomas A -- P01 AG036695/AG/NIA NIH HHS/ -- R01 AG047820/AG/NIA NIH HHS/ -- R01 AR062185/AR/NIAMS NIH HHS/ -- R37 AG023806/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1199-204. doi: 10.1126/science.aab3388.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cells and Regenerative Medicine Center, Center for Cell and Gene Therapy, and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. goodell@bcm.edu rando@stanford.edu. ; Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA, and Center for Regenerative Rehabilitation, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA. goodell@bcm.edu rando@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*physiology ; Aging/*physiology ; Animals ; Cell Aging ; Epigenesis, Genetic ; Genetic Drift ; *Health ; Humans ; Mice ; Mutation ; Organ Specificity ; Selection, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottlieb, Roberta A -- Bernstein, Daniel -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1162-3. doi: 10.1126/science.aad8222.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. roberta.gottlieb@cshs.org. ; Department of Pediatrics, Stanford University, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785456" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Heart/*embryology ; Heart Failure/*metabolism ; Male ; Mitochondria, Heart/*metabolism/*physiology ; Mitochondrial Degradation/*physiology ; *Mitochondrial Dynamics ; Myocardium/*metabolism ; Ubiquitin-Protein Ligases/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1144-7. doi: 10.1126/science.350.6265.1144.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785454" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Breeding ; Cattle ; Europe ; *Extinction, Biological
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, David -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1182-5. doi: 10.1126/science.350.6265.1182.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785473" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Body Weight ; Cats ; Dogs ; Humans ; *Longevity ; Pets/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2015 Dec 4;350(6265):1148-51. doi: 10.1126/science.350.6265.1148. Epub 2015 Dec 3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26785455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bison ; *Conservation of Natural Resources ; *Herbivory ; *Parks, Recreational ; *Permafrost ; Siberia ; *Taiga
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2016 Apr 8;352(6282):128-9. doi: 10.1126/science.352.6282.128. Epub 2016 Apr 7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27124428" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/virology ; Angola/epidemiology ; Animals ; Chick Embryo ; Disease Outbreaks/*prevention & control ; Humans ; Vaccination/statistics & numerical data ; World Health Organization ; Yellow Fever/*epidemiology/*prevention & control ; Yellow Fever Vaccine/*administration & dosage
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1143. doi: 10.1126/science.351.6278.1143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26965608" target="_blank"〉PubMed〈/a〉
    Keywords: Acinetobacter/*growth & development ; Animals ; *Death ; Humans ; Mice ; Moraxellaceae/*growth & development ; Rhizobiaceae/*growth & development ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2016 Apr 22;352(6284):391-2. doi: 10.1126/science.352.6284.391. Epub 2016 Apr 21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27102452" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Communicable Diseases/diagnosis/*epidemiology/etiology ; Echinococcosis/diagnosis/epidemiology ; Echinococcus/isolation & purification ; *Emigration and Immigration ; Europe ; Humans ; Mass Screening ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; *Refugees
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, Gary J -- DK 020541/DK/NIDDK NIH HHS/ -- DK 026687/DK/NIDDK NIH HHS/ -- DK 105441/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1268-9. doi: 10.1126/science.aaf5216. Epub 2016 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine & Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. gary.schwartz@einstein.yu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989239" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Energy Metabolism/*physiology ; Feeding Behavior/*physiology ; Hyperphagia/*genetics ; Male ; N-Acetylglucosaminyltransferases/*physiology ; Paraventricular Hypothalamic Nucleus/*physiology
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  • 70
    Publication Date: 2016-02-26
    Description: In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzer, Martin -- Makki, Kassem -- Storelli, Gilles -- Machuca-Gayet, Irma -- Srutkova, Dagmar -- Hermanova, Petra -- Martino, Maria Elena -- Balmand, Severine -- Hudcovic, Tomas -- Heddi, Abdelaziz -- Rieusset, Jennifer -- Kozakova, Hana -- Vidal, Hubert -- Leulier, Francois -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):854-7. doi: 10.1126/science.aad8588.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1, Unite Mixte de Recherche 5242, 46 Allee d'Italie, 69364 Lyon Cedex 07, France. Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic. ; Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1, Unite Mixte de Recherche 5242, 46 Allee d'Italie, 69364 Lyon Cedex 07, France. Laboratoire CarMeN, Universite Lyon 1, Unite Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculte de Medecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France. ; Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1, Unite Mixte de Recherche 5242, 46 Allee d'Italie, 69364 Lyon Cedex 07, France. ; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic. ; UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Universite de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France. ; Laboratoire CarMeN, Universite Lyon 1, Unite Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculte de Medecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912894" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight/*physiology ; Diet ; Femur/growth & development ; Gastrointestinal Microbiome/*physiology ; Lactobacillus plantarum/*physiology ; Malnutrition/*microbiology/*physiopathology ; Mice ; Mice, Inbred BALB C ; Weight Gain/*physiology
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  • 71
    Publication Date: 2016-01-23
    Description: Mono-ubiquitination of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs), but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair, but we show that recruitment of Fan1 by Ub-Fancd2 is dispensable for ICL repair. Instead, Fan1 recruitment--and activity--restrains DNA replication fork progression and prevents chromosome abnormalities from occurring when DNA replication forks stall, even in the absence of ICLs. Accordingly, Fan1 nuclease-defective knockin mice are cancer-prone. Moreover, we show that a Fan1 variant in high-risk pancreatic cancers abolishes recruitment by Ub-Fancd2 and causes genetic instability without affecting ICL repair. Therefore, Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770513/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770513/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lachaud, Christophe -- Moreno, Alberto -- Marchesi, Francesco -- Toth, Rachel -- Blow, J Julian -- Rouse, John -- WT096598MA/Wellcome Trust/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):846-9. doi: 10.1126/science.aad5634. Epub 2016 Jan 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. ; Centre for Gene Regulation and Expression, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. ; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK. ; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. j.rouse@dundee.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26797144" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Chromosome Aberrations ; DNA Repair ; *DNA Replication ; Endodeoxyribonucleases/genetics/*metabolism ; Fanconi Anemia Complementation Group D2 Protein/genetics/*metabolism ; Female ; Gene Knock-In Techniques ; Genetic Predisposition to Disease ; Genomic Instability/*genetics ; Liver Neoplasms/genetics/pathology ; Lung Neoplasms/genetics/pathology ; Lymphoma/genetics/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Pancreatic Neoplasms/*genetics ; *Ubiquitination
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  • 72
    Publication Date: 2016-03-19
    Description: Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to dietary factors and metabolic signals from peripheral organs. It is unclear how the brain interprets these signals. O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc and is regulated by nutrient access. Here, we show that acute deletion of OGT from alphaCaMKII-positive neurons in adult mice caused obesity from overeating. The hyperphagia derived from the paraventricular nucleus (PVN) of the hypothalamus, where loss of OGT was associated with impaired satiety. These results identify O-GlcNAcylation in alphaCaMKII neurons of the PVN as an important molecular mechanism that regulates feeding behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817221/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817221/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lagerlof, Olof -- Slocomb, Julia E -- Hong, Ingie -- Aponte, Yeka -- Blackshaw, Seth -- Hart, Gerald W -- Huganir, Richard L -- N01-HV-00240/HV/NHLBI NIH HHS/ -- P01 HL107153/HL/NHLBI NIH HHS/ -- P01HL107153/HL/NHLBI NIH HHS/ -- R01 DK061671/DK/NIDDK NIH HHS/ -- R01 NS036715/NS/NINDS NIH HHS/ -- R01DK6167/DK/NIDDK NIH HHS/ -- R01NS036715/NS/NINDS NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1293-6. doi: 10.1126/science.aad5494.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; National Institute on Drug Abuse + National Institutes of Health/Johns Hopkins University Graduate Partnership Program, Baltimore, MD 21224, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Intramural Research Program, Neuronal Circuits and Behavior Unit, National Institute on Drug Abuse, Baltimore, MD 21224, USA. ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ; Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. rhuganir@jhmi.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989246" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylglucosamine/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Energy Metabolism/genetics/*physiology ; Feeding Behavior/*physiology ; Gene Deletion ; Homeostasis/genetics ; Hyperphagia/*genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; N-Acetylglucosaminyltransferases/genetics/*physiology ; Neurons/enzymology ; Obesity/genetics ; Paraventricular Hypothalamic Nucleus/cytology/enzymology/*physiology ; Protein Processing, Post-Translational ; Satiety Response/physiology
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  • 73
    Publication Date: 2016-04-02
    Description: When animals encounter conflict they initiate and escalate aggression to establish and maintain a social hierarchy. The neural mechanisms by which animals resolve fighting behaviors to determine such social hierarchies remain unknown. We identified two subregions of the dorsal habenula (dHb) in zebrafish that antagonistically regulate the outcome of conflict. The losing experience reduced neural transmission in the lateral subregion of dHb (dHbL)-dorsal/intermediate interpeduncular nucleus (d/iIPN) circuit. Silencing of the dHbL or medial subregion of dHb (dHbM) caused a stronger predisposition to lose or win a fight, respectively. These results demonstrate that the dHbL and dHbM comprise a dual control system for conflict resolution of social aggression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, Ming-Yi -- Amo, Ryunosuke -- Kinoshita, Masae -- Cherng, Bor-Wei -- Shimazaki, Hideaki -- Agetsuma, Masakazu -- Shiraki, Toshiyuki -- Aoki, Tazu -- Takahoko, Mikako -- Yamazaki, Masako -- Higashijima, Shin-ichi -- Okamoto, Hitoshi -- New York, N.Y. -- Science. 2016 Apr 1;352(6281):87-90. doi: 10.1126/science.aac9508.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. ; Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan. ; Laboratory for Neural Computation and Adaptation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. ; National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Aichi 444-8787, Japan. ; Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan. Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Waseda University, Tokyo 162-8430, Japan. hitoshi@brain.riken.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27034372" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*physiology ; Animals ; *Conflict (Psychology) ; Habenula/*physiology ; Hierarchy, Social ; Interpeduncular Nucleus/physiology ; *Negotiating ; Synaptic Transmission ; Zebrafish
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larson, Christina -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):323-4. doi: 10.1126/science.351.6271.323.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26797990" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Shells ; Animals ; Art ; *Bivalvia ; China ; *Endangered Species
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):326-7. doi: 10.1126/science.351.6271.326.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26797993" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; Birds ; *Carps ; Cattle ; *Environmental Restoration and Remediation ; Herbivory ; *Introduced Species ; Oregon ; Violence
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landolt, Hans-Peter -- Holst, Sebastian C -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):517-8. doi: 10.1126/science.aaf8178.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland. landolt@pharma.uzh.ch. ; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cations/*metabolism ; Cerebral Cortex/*physiology ; Male ; Potassium/*metabolism ; Sleep/*physiology ; Wakefulness/*physiology
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  • 77
    Publication Date: 2016-04-23
    Description: Ecological character displacement is a process of morphological divergence that reduces competition for limited resources. We used genomic analysis to investigate the genetic basis of a documented character displacement event in Darwin's finches on Daphne Major in the Galapagos Islands: The medium ground finch diverged from its competitor, the large ground finch, during a severe drought. We discovered a genomic region containing the HMGA2 gene that varies systematically among Darwin's finch species with different beak sizes. Two haplotypes that diverged early in the radiation were involved in the character displacement event: Genotypes associated with large beak size were at a strong selective disadvantage in medium ground finches (selection coefficient s = 0.59). Thus, a major locus has apparently facilitated a rapid ecological diversification in the adaptive radiation of Darwin's finches.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamichhaney, Sangeet -- Han, Fan -- Berglund, Jonas -- Wang, Chao -- Almen, Markus Sallman -- Webster, Matthew T -- Grant, B Rosemary -- Grant, Peter R -- Andersson, Leif -- New York, N.Y. -- Science. 2016 Apr 22;352(6284):470-4. doi: 10.1126/science.aad8786.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. ; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. ; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden. Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. leif.andersson@imbim.uu.se.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27102486" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beak/*anatomy & histology ; Body Size/genetics ; *Droughts ; Ecuador ; Female ; Finches/*anatomy & histology/classification/*genetics ; Genomics ; Genotype ; HMGA2 Protein/genetics ; Haplotypes ; Organ Size/genetics ; Phylogeny ; *Quantitative Trait Loci ; *Selection, Genetic
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  • 78
    Publication Date: 2016-03-26
    Description: Shadlen et al's Comment focuses on extrapolations of our results that were not implied or asserted in our Report. They discuss alternate analyses of average firing rates in other tasks, the relationship between neural activity and behavior, and possible extensions of the standard models we examined. Although interesting to contemplate, these points are not germane to the findings of our Report: that stepping dynamics provided a better statistical description of lateral intraparietal area spike trains than diffusion-to-bound dynamics for a majority of neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Latimer, Kenneth W -- Yates, Jacob L -- Meister, Miriam L R -- Huk, Alexander C -- Pillow, Jonathan W -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1406. doi: 10.1126/science.aad3596.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. ; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA. ; Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA. Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ 08544, USA. pillow@princeton.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Choice Behavior/*physiology ; Decision Making/*physiology ; Male ; Parietal Lobe/*physiology
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  • 79
    Publication Date: 2016-03-26
    Description: Latimeret al (Reports, 10 July 2015, p. 184) claim that during perceptual decision formation, parietal neurons undergo one-time, discrete steps in firing rate instead of gradual changes that represent the accumulation of evidence. However, that conclusion rests on unsubstantiated assumptions about the time window of evidence accumulation, and their stepping model cannot explain existing data as effectively as evidence-accumulation models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shadlen, Michael N -- Kiani, Roozbeh -- Newsome, William T -- Gold, Joshua I -- Wolpert, Daniel M -- Zylberberg, Ariel -- Ditterich, Jochen -- de Lafuente, Victor -- Yang, Tianming -- Roitman, Jamie -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1406. doi: 10.1126/science.aad3242.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI) and Department of Neuroscience, Columbia University, New York, NY, USA. shadlen@columbia.edu. ; Center for Neural Science, New York University, New York, NY, USA. ; HHMI and Stanford University, Stanford, CA, USA. ; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Engineering, University of Cambridge, Cambridge, UK. ; HHMI and Department of Neuroscience, Columbia University, New York, NY, USA. ; Center for Neuroscience and Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA, USA. ; Institute for Neuroscience, National Autonomous University of Mexico, Queretaro, Mexico. ; Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China. ; Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Choice Behavior/*physiology ; Decision Making/*physiology ; Male ; Parietal Lobe/*physiology
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Servick, Kelly -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):15. doi: 10.1126/science.351.6268.15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; California ; Cell Differentiation ; Clinical Trials as Topic ; Drug Industry ; Embryonic Stem Cells/cytology/*transplantation ; Financing, Organized ; Humans ; Photoreceptor Cells/physiology ; Rats ; Regenerative Medicine/*economics/*trends ; Retina/cytology/physiology ; Stem Cell Research/*economics
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2016 Jan 8;351(6269):111-2. doi: 10.1126/science.351.6269.111.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744387" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Drinking Water ; *Droughts ; Humans ; Indian Ocean ; Iraq ; Mesopotamia ; Salinity ; Warfare ; Water Resources/*supply & distribution ; *Wetlands
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):16-9. doi: 10.1126/science.351.6268.16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; Communicable Disease Control/*economics ; Financial Management ; Humans ; National Institutes of Health (U.S.) ; United States ; Vaccines/*economics
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  • 83
    Publication Date: 2016-02-27
    Description: Oocytes differentiate in diverse species by receiving organelles and cytoplasm from sister germ cells while joined in germline cysts or syncytia. Mouse primordial germ cells form germline cysts, but the role of cysts in oogenesis is unknown. We find that mouse germ cells receive organelles from neighboring cyst cells and build a Balbiani body to become oocytes, whereas nurselike germ cells die. Organelle movement, Balbiani body formation, and oocyte fate determination are selectively blocked by low levels of microtubule-dependent transport inhibitors. Membrane breakdown within the cyst and an apoptosis-like process are associated with organelle transfer into the oocyte, events reminiscent of nurse cell dumping in Drosophila We propose that cytoplasmic and organelle transport plays an evolutionarily conserved and functionally important role in mammalian oocyte differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lei, Lei -- Spradling, Allan C -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Apr 1;352(6281):95-9. doi: 10.1126/science.aad2156. Epub 2016 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA. spradling@ciwemb.edu leile@med.umich.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26917595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Biological Evolution ; Cytoplasm/physiology/ultrastructure ; Female ; Giant Cells/*cytology ; Mice ; Microtubules/drug effects/physiology ; Oocytes/*cytology ; *Oogenesis ; Organelles/*physiology
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  • 84
    Publication Date: 2016-01-30
    Description: Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three species, CFTR secreted bicarbonate into airway surface liquid. In humans and pigs lacking CFTR, unchecked H(+) secretion by the nongastric H(+)/K(+) adenosine triphosphatase (ATP12A) acidified airway surface liquid, which impaired airway host defenses. In contrast, mouse airways expressed little ATP12A and secreted minimal H(+); consequently, airway surface liquid in CF and non-CF mice had similar pH. Inhibiting ATP12A reversed host defense abnormalities in human and pig airways. Conversely, expressing ATP12A in CF mouse airways acidified airway surface liquid, impaired defenses, and increased airway bacteria. These findings help explain why CF mice are protected from infection and nominate ATP12A as a potential therapeutic target for CF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shah, Viral S -- Meyerholz, David K -- Tang, Xiao Xiao -- Reznikov, Leah -- Abou Alaiwa, Mahmoud -- Ernst, Sarah E -- Karp, Philip H -- Wohlford-Lenane, Christine L -- Heilmann, Kristopher P -- Leidinger, Mariah R -- Allen, Patrick D -- Zabner, Joseph -- McCray, Paul B Jr -- Ostedgaard, Lynda S -- Stoltz, David A -- Randak, Christoph O -- Welsh, Michael J -- 5T32GM007337/GM/NIGMS NIH HHS/ -- DK054759/DK/NIDDK NIH HHS/ -- F30 HL123239/HL/NHLBI NIH HHS/ -- F30HL123239/HL/NHLBI NIH HHS/ -- HL091842/HL/NHLBI NIH HHS/ -- HL117744/HL/NHLBI NIH HHS/ -- HL51670/HL/NHLBI NIH HHS/ -- K08HL097071/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Jan 29;351(6272):503-7. doi: 10.1126/science.aad5589.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Iowa, Iowa City, IA 52242, USA. Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. ; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA. ; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA. Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA. ; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA. ; Department of Pediatrics University of Iowa, Iowa City, IA 52242, USA. ; Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA. ; Department of Pediatrics University of Iowa, Iowa City, IA 52242, USA. Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA. ; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA. Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242, USA. ; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA. Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26823428" target="_blank"〉PubMed〈/a〉
    Keywords: Acids/metabolism ; Animals ; Bicarbonates/metabolism ; Cystic Fibrosis/*metabolism/*microbiology ; H(+)-K(+)-Exchanging ATPase/genetics/*metabolism ; Humans ; Hydrogen-Ion Concentration ; Lung/*metabolism/*microbiology ; Mice ; Mice, Inbred CFTR/genetics/metabolism ; Mice, Transgenic ; Swine
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  • 85
    Publication Date: 2016-01-02
    Description: Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet affects offspring metabolism. Protein restriction in mice affects small RNA (sRNA) levels in mature sperm, with decreased let-7 levels and increased amounts of 5' fragments of glycine transfer RNAs (tRNAs). In testicular sperm, tRNA fragments are scarce but increase in abundance as sperm mature in the epididymis. Epididymosomes (vesicles that fuse with sperm during epididymal transit) carry RNA payloads matching those of mature sperm and can deliver RNAs to immature sperm in vitro. Functionally, tRNA-glycine-GCC fragments repress genes associated with the endogenous retroelement MERVL, in both embryonic stem cells and embryos. Our results shed light on sRNA biogenesis and its dietary regulation during posttesticular sperm maturation, and they also link tRNA fragments to regulation of endogenous retroelements active in the preimplantation embryo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, Upasna -- Conine, Colin C -- Shea, Jeremy M -- Boskovic, Ana -- Derr, Alan G -- Bing, Xin Y -- Belleannee, Clemence -- Kucukural, Alper -- Serra, Ryan W -- Sun, Fengyun -- Song, Lina -- Carone, Benjamin R -- Ricci, Emiliano P -- Li, Xin Z -- Fauquier, Lucas -- Moore, Melissa J -- Sullivan, Robert -- Mello, Craig C -- Garber, Manuel -- Rando, Oliver J -- DP1ES025458/DP/NCCDPHP CDC HHS/ -- R01HD080224/HD/NICHD NIH HHS/ -- UL1 TR000161/TR/NCATS NIH HHS/ -- UL1 TR001453/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Jan 22;351(6271):391-6. doi: 10.1126/science.aad6780. Epub 2015 Dec 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Obstetrics, Gynecology and Reproduction, Universite Laval, Centre Hospitalier Universitaire de Quebec Research Center, Quebec City, Quebec G1V 4G2, Canada. ; RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. RNAi Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. oliver.rando@umassmed.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/metabolism ; Diet, Protein-Restricted ; Epididymis/metabolism ; *Fertilization ; *Gene Expression Regulation ; Male ; Mice ; MicroRNAs/metabolism ; RNA, Transfer, Gly/*metabolism/*physiology ; Retroelements/genetics ; *Sperm Maturation ; Spermatozoa/*metabolism ; Testis/metabolism
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  • 86
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):13. doi: 10.1126/science.351.6268.13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26721982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/chemistry/genetics/metabolism ; *Epigenesis, Genetic ; Male ; Metabolism/*genetics ; Mice ; RNA, Transfer/genetics/*metabolism ; *Spermatozoa
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  • 87
    Publication Date: 2016-04-30
    Description: Sleep has been described in animals ranging from worms to humans. Yet the electrophysiological characteristics of brain sleep, such as slow-wave (SW) and rapid eye movement (REM) activities, are thought to be restricted to mammals and birds. Recording from the brain of a lizard, the Australian dragon Pogona vitticeps, we identified SW and REM sleep patterns, thus pushing back the probable evolution of these dynamics at least to the emergence of amniotes. The SW and REM sleep patterns that we observed in lizards oscillated continuously for 6 to 10 hours with a period of ~80 seconds. The networks controlling SW-REM antagonism in amniotes may thus originate from a common, ancient oscillator circuit. Lizard SW dynamics closely resemble those observed in rodent hippocampal CA1, yet they originate from a brain area, the dorsal ventricular ridge, that has no obvious hodological similarity with the mammalian hippocampus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shein-Idelson, Mark -- Ondracek, Janie M -- Liaw, Hua-Peng -- Reiter, Sam -- Laurent, Gilles -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):590-5. doi: 10.1126/science.aaf3621.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Brain Research, Frankfurt am Main, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126045" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Brain/*physiology ; CA1 Region, Hippocampal/physiology ; Lizards/*physiology ; Sleep, REM/*physiology
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  • 88
    Publication Date: 2016-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis S -- Anderson, James M -- Austin, Christopher P -- Battey, James F -- Birnbaum, Linda S -- Briggs, Josephine P -- Clayton, Janine A -- Cuthbert, Bruce -- Eisinger, Robert W -- Fauci, Anthony S -- Gallin, John I -- Gibbons, Gary H -- Glass, Roger I -- Gottesman, Michael M -- Gray, Patricia A -- Green, Eric D -- Greider, Franziska B -- Hodes, Richard -- Hudson, Kathy L -- Humphreys, Betsy -- Katz, Stephen I -- Koob, George F -- Koroshetz, Walter J -- Lauer, Michael S -- Lorsch, Jon R -- Lowy, Douglas R -- McGowan, John J -- Murray, David M -- Nakamura, Richard -- Norris, Andrea -- Perez-Stable, Eliseo J -- Pettigrew, Roderic I -- Riley, William T -- Rodgers, Griffin P -- Sieving, Paul A -- Somerman, Martha J -- Spong, Catherine Y -- Tabak, Lawrence A -- Volkow, Nora D -- Wilder, Elizabeth L -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1405. doi: 10.1126/science.351.6280.1405-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Office of the Director, NIH, Bethesda, MD 20892, USA. collinsf@mail.nih.gov. ; Division of Program Coordination, Planning, and Strategic Initiatives, NIH, Bethesda, MD 20892, USA. ; National Center for Advancing Translational Science, NIH, Rockville, MD 20850, USA. ; National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA. ; National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. ; National Center for Complementary and Integrative Health, NIH, Bethesda, MD 20892, USA. ; Office of Research on Women's Health, NIH, Bethesda, MD 20892, USA. ; National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. ; Office of AIDS Research, NIH, Bethesda, MD 20892, USA. ; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. ; Clinical Center, NIH, Bethesda, MD 20892, USA. ; National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. ; Fogarty International Center, NIH, Bethesda, MD 20892, USA. ; Office of Intramural Research, NIH, Bethesda, MD 20892, USA. ; National Institute of Nursing Research, NIH, Bethesda, MD 20892, USA. ; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. ; Office of Research Infrastructure Programs, NIH, Bethesda, MD 20892, USA. ; National Institute on Aging, NIH, Bethesda, MD 20892, USA. ; Office of the Director, NIH, Bethesda, MD 20892, USA. ; National Library of Medicine, NIH, Bethesda, MD 20892, USA. ; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA. ; National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA. ; NINDS, NIH, Bethesda, MD 20892, USA. ; Office of Extramural Research, NIH, Bethesda, MD 20892, USA. ; National Institute of General Medical Sciences, NIH, Bethesda, MD 20892, USA. ; National Cancer Institute, NIH, Bethesda, MD 20892, USA. ; Office of Management, NIH, Bethesda, MD 20892, USA. ; Office of Disease Prevention, NIH, Bethesda, MD 20892, USA. ; Center for Scientific Review, NIH, Bethesda, MD 20892, USA. ; Center for Information Technology, NIH, Bethesda, MD 20892, USA. ; National Institute on Minority Health and Health Disparities, NIH, Bethesda, MD 20892, USA. ; National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA. ; Office of Behavioral and Social Sciences Research, NIH, Bethesda, MD 20892, USA. ; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. ; National Eye Institute, NIH, Bethesda, MD 20892, USA. ; National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. ; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. ; National Institute on Drug Abuse, NIH, Bethesda, MD 20892, USA. ; Office of Strategic Coordination, NIH, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27013720" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; Humans ; National Institutes of Health (U.S.)/*economics
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  • 89
    Publication Date: 2016-02-26
    Description: Mota and Herculano-Houzel (Reports, 3 July 2015, p. 74) assign power functions to neuroanatomical data and present a model to account for evolutionary patterns of cortical folding in the mammalian brain. We detail how the model assumptions are in conflict with experimental and observational work and show that the model itself does not accurately fit the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewitus, Eric -- Kelava, Iva -- Kalinka, Alex T -- Tomancak, Pavel -- Huttner, Wieland B -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):825. doi: 10.1126/science.aad2029.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie, Ecole Normale Superieure, Paris, France. lewitus@biologie.ens.fr huttner@mpi-cbg.de. ; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. ; Institute of Population Genetics, Vetmeduni, Vienna, Austria. ; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. ; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. lewitus@biologie.ens.fr huttner@mpi-cbg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912886" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cerebral Cortex ; Humans ; Lissencephaly/*pathology ; Neurons/*cytology
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  • 90
    Publication Date: 2016-02-26
    Description: Voltage-gated CaV1.2 channels (L-type calcium channel alpha1C subunits) are critical mediators of transcription-dependent neural plasticity. Whether these channels signal via the influx of calcium ion (Ca(2+)), voltage-dependent conformational change (VDeltaC), or a combination of the two has thus far been equivocal. We fused CaV1.2 to a ligand-gated Ca(2+)-permeable channel, enabling independent control of localized Ca(2+) and VDeltaC signals. This revealed an unexpected dual requirement: Ca(2+) must first mobilize actin-bound Ca(2+)/calmodulin-dependent protein kinase II, freeing it for subsequent VDeltaC-mediated accumulation. Neither signal alone sufficed to activate transcription. Signal order was crucial: Efficiency peaked when Ca(2+) preceded VDeltaC by 10 to 20 seconds. CaV1.2 VDeltaC synergistically augmented signaling by N-methyl-d-aspartate receptors. Furthermore, VDeltaC mistuning correlated with autistic symptoms in Timothy syndrome. Thus, nonionic VDeltaC signaling is vital to the function of CaV1.2 in synaptic and neuropsychiatric processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Boxing -- Tadross, Michael R -- Tsien, Richard W -- New York, N.Y. -- Science. 2016 Feb 19;351(6275):863-7. doi: 10.1126/science.aad3647.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience and Physiology and New York University Neuroscience Institute, New York, NY 10016, USA. ; Department of Molecular and Cellular Physiology, Beckman Center, School of Medicine, Stanford University, Stanford, CA 94305, USA. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. tadrossm@janelia.hhmi.org. ; Department of Neuroscience and Physiology and New York University Neuroscience Institute, New York, NY 10016, USA. Department of Molecular and Cellular Physiology, Beckman Center, School of Medicine, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912895" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autistic Disorder/genetics/metabolism ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/chemistry/*metabolism ; *Calcium Signaling ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism ; Cells, Cultured ; Cyclic AMP Response Element-Binding Protein/metabolism ; *Gene Expression Regulation ; HEK293 Cells ; Hippocampus/cytology ; Humans ; Long QT Syndrome/genetics/metabolism ; Neuronal Plasticity/*genetics ; Neurons/drug effects/*metabolism ; Nimodipine/pharmacology ; Protein Conformation/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism ; Syndactyly/genetics/metabolism
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  • 91
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shoubridge, Eric A -- New York, N.Y. -- Science. 2016 Apr 1;352(6281):31-2. doi: 10.1126/science.aaf5248. Epub 2016 Mar 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Montreal Neurological Institute, Department of Human Genetics, McGill University, Montreal, Quebec, Canada. eric@ericpc.mni.mcgill.ca.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27034357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Leigh Disease/*genetics/*therapy ; Mitochondria/*metabolism ; Oxygen/*metabolism ; Von Hippel-Lindau Tumor Suppressor Protein/*genetics
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  • 92
    Publication Date: 2016-04-30
    Description: Sahl et al in their Comment raise criticisms of our work that fall into three classes: image artifacts, resolution criteria, and comparative performance on live cells. We explore each of these in turn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Dong -- Betzig, Eric -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):527. doi: 10.1126/science.aad8396. Epub 2016 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Laboratory of Biological Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147. lidong@ibp.ac.cn betzige@janelia.hhmi.org. ; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147. lidong@ibp.ac.cn betzige@janelia.hhmi.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytoskeleton/*ultrastructure ; *Endocytosis ; Imaging, Three-Dimensional/*methods ; Microscopy, Fluorescence/*methods ; Organelles/*ultrastructure
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  • 93
    Publication Date: 2016-02-27
    Description: Rasmussen and Svensson correctly point out that there is currently no satisfactory method to fully align the Greenland and Cariaco Basin records of climate change. However, our approach using interstadial onsets as tie-points allows direct comparison between radiocarbon dates and Greenland climate records. Crucially, both the standard Greenland and the merged Greenland-Cariaco time scales show that interstadial warming was associated with megafaunal genetic transitions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, Alan -- Turney, Chris -- Hughen, Konrad -- New York, N.Y. -- Science. 2016 Feb 26;351(6276):927. doi: 10.1126/science.aad8016.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Adelaide, Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, and Environment Institute, Adelaide, Australia. alan.cooper@adelaide.edu.au. ; Climate Change Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia. ; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26917762" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Extinction, Biological ; Global Warming/*history ; Humans
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  • 94
    Publication Date: 2016-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Junsheng -- Wang, Wei -- Axmacher, Jan Christoph -- Zhang, Yuanyuan -- Zhu, Yanpeng -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1160. doi: 10.1126/science.351.6278.1160-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biodiversity Research Center, Chinese Research Academy of Environmental Sciences, Chaoyang District, Beijing, 100012, China. lijsh@craes.org.cn wang.wei@craes.org.cn. ; UCL Department of Geography, University College London, London, WC1E 6BT, UK. ; Biodiversity Research Center, Chinese Research Academy of Environmental Sciences, Chaoyang District, Beijing, 100012, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26965616" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; *Conservation of Natural Resources ; Plants/*classification ; Vertebrates/*classification
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  • 95
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2016 Apr 1;352(6281):21-3. doi: 10.1126/science.352.6281.21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27034353" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Diabetes Mellitus, Type 1/immunology ; Infection/*immunology ; Inflammation/*immunology ; Lymph Nodes/cytology/*immunology ; Mice ; Pancreas/immunology ; T-Lymphocytes/*immunology
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    Electronic ISSN: 1095-9203
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  • 96
    Publication Date: 2016-01-02
    Description: Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simola, Daniel F -- Graham, Riley J -- Brady, Cristina M -- Enzmann, Brittany L -- Desplan, Claude -- Ray, Anandasankar -- Zwiebel, Laurence J -- Bonasio, Roberto -- Reinberg, Danny -- Liebig, Jurgen -- Berger, Shelley L -- 2009005/Howard Hughes Medical Institute/ -- DP2MH107055/DP/NCCDPHP CDC HHS/ -- T32HD083185/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):aac6633. doi: 10.1126/science.aac6633.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. ; Department of Biology, New York University, New York, NY 10003, USA. ; Department of Entomology, University of California, Riverside, CA 92521, USA. ; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Molecular Pharmacology and Biochemistry, New York University School of Medicine, New York, NY 10016, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26722000" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Ants/drug effects/*genetics/*physiology ; *Behavior, Animal ; Chromatin/metabolism ; *Epigenesis, Genetic ; Histone Deacetylase 2/antagonists & inhibitors/genetics/*physiology ; Histone Deacetylase Inhibitors/pharmacology ; Protein Processing, Post-Translational ; *Social Behavior ; Social Class ; Transcriptome
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  • 97
    Publication Date: 2016-02-26
    Description: Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neandertal variants to over 1000 electronic health record (EHR)-derived phenotypes in ~28,000 adults of European ancestry. We discovered and replicated associations of Neandertal alleles with neurological, psychiatric, immunological, and dermatological phenotypes. Neandertal alleles together explained a significant fraction of the variation in risk for depression and skin lesions resulting from sun exposure (actinic keratosis), and individual Neandertal alleles were significantly associated with specific human phenotypes, including hypercoagulation and tobacco use. Our results establish that archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of hundreds of Neandertal haplotypes, and demonstrate the utility of EHR data in evolutionary analyses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simonti, Corinne N -- Vernot, Benjamin -- Bastarache, Lisa -- Bottinger, Erwin -- Carrell, David S -- Chisholm, Rex L -- Crosslin, David R -- Hebbring, Scott J -- Jarvik, Gail P -- Kullo, Iftikhar J -- Li, Rongling -- Pathak, Jyotishman -- Ritchie, Marylyn D -- Roden, Dan M -- Verma, Shefali S -- Tromp, Gerard -- Prato, Jeffrey D -- Bush, William S -- Akey, Joshua M -- Denny, Joshua C -- Capra, John A -- 1K22LM011938/LM/NLM NIH HHS/ -- 1R01GM114128/GM/NIGMS NIH HHS/ -- 5T32EY021453/EY/NEI NIH HHS/ -- R01GM110068/GM/NIGMS NIH HHS/ -- R01LM010685/LM/NLM NIH HHS/ -- U01HG004438/HG/NHGRI NIH HHS/ -- U01HG004608/HG/NHGRI NIH HHS/ -- U01HG004609/HG/NHGRI NIH HHS/ -- U01HG004610/HG/NHGRI NIH HHS/ -- U01HG006378/HG/NHGRI NIH HHS/ -- U01HG006379/HG/NHGRI NIH HHS/ -- U01HG006380/HG/NHGRI NIH HHS/ -- U01HG006382/HG/NHGRI NIH HHS/ -- U01HG006385/HG/NHGRI NIH HHS/ -- U01HG006388/HG/NHGRI NIH HHS/ -- U01HG006389/HG/NHGRI NIH HHS/ -- U01HG008657/HG/NHGRI NIH HHS/ -- U01HG04599/HG/NHGRI NIH HHS/ -- U01HG04603/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2016 Feb 12;351(6274):737-41. doi: 10.1126/science.aad2149.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. ; Department of Genome Sciences, University of Washington, Seattle, WA, USA. ; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. ; Mount Sinai School of Medicine, New York, NY, USA. ; Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA. ; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ; Department of Genome Sciences, University of Washington, Seattle, WA, USA. Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA. ; Center for Human Genetics, Marshfield Clinic, Marshfield, WI, USA. ; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. ; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. ; Division of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA. Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA. ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Department of Medicine, Vanderbilt University, Nashville, TN, USA. Department of Pharmacology, Vanderbilt University, Nashville, TN, USA. ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA. ; Weis Center for Research, Geisinger Health System, Danville, PA, USA. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Science, Stellenbosch University, Tygerberg, South Africa. ; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA. ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Department of Medicine, Vanderbilt University, Nashville, TN, USA. ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. Center for Quantitative Sciences, Vanderbilt University, Nashville, TN, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912863" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Depression/genetics ; Disease/*genetics ; European Continental Ancestry Group/genetics ; Evolution, Molecular ; Genetic Variation ; Genome, Human ; Haplotypes ; Humans ; Keratosis, Actinic/genetics ; Neanderthals/*genetics ; Phenotype
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  • 98
    Publication Date: 2016-02-27
    Description: Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. We ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAbs) that neutralize recent and previous outbreak variants of Ebola virus and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as 5 days after challenge. Treatment with a single human mAb suggests that a simplified therapeutic strategy for human Ebola infection may be possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corti, Davide -- Misasi, John -- Mulangu, Sabue -- Stanley, Daphne A -- Kanekiyo, Masaru -- Wollen, Suzanne -- Ploquin, Aurelie -- Doria-Rose, Nicole A -- Staupe, Ryan P -- Bailey, Michael -- Shi, Wei -- Choe, Misook -- Marcus, Hadar -- Thompson, Emily A -- Cagigi, Alberto -- Silacci, Chiara -- Fernandez-Rodriguez, Blanca -- Perez, Laurent -- Sallusto, Federica -- Vanzetta, Fabrizia -- Agatic, Gloria -- Cameroni, Elisabetta -- Kisalu, Neville -- Gordon, Ingelise -- Ledgerwood, Julie E -- Mascola, John R -- Graham, Barney S -- Muyembe-Tamfun, Jean-Jacques -- Trefry, John C -- Lanzavecchia, Antonio -- Sullivan, Nancy J -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1339-42. doi: 10.1126/science.aad5224. Epub 2016 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. Humabs BioMed SA, 6500 Bellinzona, Switzerland. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. ; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. ; Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. ; Humabs BioMed SA, 6500 Bellinzona, Switzerland. ; National Institute for Biomedical Research, National Laboratory of Public Health, Kinshasa B.P. 1197, Democratic Republic of the Congo. ; Institute for Research in Biomedicine, Universita della Svizzera Italiana, CH-6500 Bellinzona, Switzerland. Institute of Microbiology, ETH Zurich, CH-8093 Zurich, Switzerland. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. njsull@mail.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26917593" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Antibodies, Monoclonal/*administration & dosage/immunology/isolation & ; purification ; Antibodies, Neutralizing/*administration & dosage/immunology/isolation & ; purification ; Antibodies, Viral/*administration & dosage/immunology/isolation & purification ; Clinical Trials as Topic ; Disease Outbreaks ; Ebolavirus/*immunology ; Female ; Hemorrhagic Fever, Ebola/epidemiology/*prevention & control ; Humans ; Macaca ; Male ; Molecular Sequence Data ; Survivors
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2016-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1126. doi: 10.1126/science.351.6278.1126.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26965598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol, HDL/*blood ; Coronary Disease/*blood/*genetics ; Female ; Humans ; Male ; Scavenger Receptors, Class B/*genetics
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  • 100
    Publication Date: 2016-02-26
    Description: The fungal kingdom is the source of almost all industrial enzymes in use for lignocellulose bioprocessing. We developed a systems-level approach that integrates transcriptomic sequencing, proteomics, phenotype, and biochemical studies of relatively unexplored basal fungi. Anaerobic gut fungi isolated from herbivores produce a large array of biomass-degrading enzymes that synergistically degrade crude, untreated plant biomass and are competitive with optimized commercial preparations from Aspergillus and Trichoderma. Compared to these model platforms, gut fungal enzymes are unbiased in substrate preference due to a wealth of xylan-degrading enzymes. These enzymes are universally catabolite-repressed and are further regulated by a rich landscape of noncoding regulatory RNAs. Additionally, we identified several promising sequence-divergent enzyme candidates for lignocellulosic bioprocessing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Solomon, Kevin V -- Haitjema, Charles H -- Henske, John K -- Gilmore, Sean P -- Borges-Rivera, Diego -- Lipzen, Anna -- Brewer, Heather M -- Purvine, Samuel O -- Wright, Aaron T -- Theodorou, Michael K -- Grigoriev, Igor V -- Regev, Aviv -- Thompson, Dawn A -- O'Malley, Michelle A -- New York, N.Y. -- Science. 2016 Mar 11;351(6278):1192-5. doi: 10.1126/science.aad1431. Epub 2016 Feb 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, University of California, Santa Barbara (UCSB), Santa Barbara, CA 93106, USA. ; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA. ; U.S. Department of Energy (DOE) Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA. ; Earth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA. ; Earth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA. ; Animal Production, Welfare and Veterinary Sciences, Harper Adams University, Newport, Shropshire TF10 8NB, UK. ; Department of Chemical Engineering, University of California, Santa Barbara (UCSB), Santa Barbara, CA 93106, USA. momalley@engineering.ucsb.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912365" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspergillus/*enzymology/genetics/isolation & purification ; Biotechnology/*methods ; Cellulases/genetics/isolation & purification/*metabolism ; Cellulose/metabolism ; Gastrointestinal Tract/*microbiology ; Herbivory ; RNA, Untranslated/genetics ; Substrate Specificity ; Trichoderma/*enzymology/genetics/isolation & purification ; Xylans/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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