Publication Date:
2004-03-06
Description:
The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nie, Zhiguo -- Schweitzer, Paul -- Roberts, Amanda J -- Madamba, Samuel G -- Moore, Scott D -- Siggins, George Robert -- AA06420/AA/NIAAA NIH HHS/ -- AA10994/AA/NIAAA NIH HHS/ -- DA03665/DA/NIDA NIH HHS/ -- DA13658/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1512-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuropharmacology and Alcohol Research Center, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001778" target="_blank"〉PubMed〈/a〉
Keywords:
Alcohol Drinking
;
Amygdala/drug effects/*physiology
;
Animals
;
Corticotropin-Releasing Hormone/pharmacology
;
Dose-Response Relationship, Drug
;
Ethanol/*pharmacology
;
Evoked Potentials/drug effects
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Neurons/drug effects/*physiology
;
Patch-Clamp Techniques
;
Receptors, Corticotropin-Releasing Hormone/antagonists &
;
inhibitors/genetics/*metabolism
;
Receptors, GABA-A/metabolism
;
Stress, Psychological/physiopathology
;
Synaptic Transmission/*drug effects
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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