Publication Date:
2016-01-02
Description:
Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simola, Daniel F -- Graham, Riley J -- Brady, Cristina M -- Enzmann, Brittany L -- Desplan, Claude -- Ray, Anandasankar -- Zwiebel, Laurence J -- Bonasio, Roberto -- Reinberg, Danny -- Liebig, Jurgen -- Berger, Shelley L -- 2009005/Howard Hughes Medical Institute/ -- DP2MH107055/DP/NCCDPHP CDC HHS/ -- T32HD083185/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 1;351(6268):aac6633. doi: 10.1126/science.aac6633.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. ; Department of Biology, New York University, New York, NY 10003, USA. ; Department of Entomology, University of California, Riverside, CA 92521, USA. ; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Molecular Pharmacology and Biochemistry, New York University School of Medicine, New York, NY 10016, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu. ; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Program in Epigenetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. simola@upenn.edu danny.reinberg@nyumc.org juergen.liebig@asu.edu bergers@upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26722000" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylation
;
Animals
;
Ants/drug effects/*genetics/*physiology
;
*Behavior, Animal
;
Chromatin/metabolism
;
*Epigenesis, Genetic
;
Histone Deacetylase 2/antagonists & inhibitors/genetics/*physiology
;
Histone Deacetylase Inhibitors/pharmacology
;
Protein Processing, Post-Translational
;
*Social Behavior
;
Social Class
;
Transcriptome
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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