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  • General Chemistry  (1.786)
  • Humans  (564)
  • Cell & Developmental Biology  (458)
  • Theoretical, Physical and Computational Chemistry
  • 1995-1999  (3.102)
  • 1945-1949
  • 1996  (3.102)
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  • 1995-1999  (3.102)
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  • 101
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    Evidence that Spt6p controls chromatin structure by a direct interaction with histones (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-07
    Beschreibung: Genetic analysis has implicated SPT6, an essential gene of Saccharomyces cerevisiae, in the control of chromatin structure. Mutations in SPT6 and particular mutations in histone genes are able to overcome transcriptional defects in strains lacking the Snf/Swi protein complex. Here it is shown that an spt6 mutation causes changes in chromatin structure in vivo. In addition, both in vivo and in vitro experiments provide evidence that Spt6p interacts directly with histones and primarily with histone H3. Consistent with these findings, Spt6p is capable of nucleosome assembly in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bortvin, A -- Winston, F -- GM32967/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1473-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633238" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chromatin/chemistry/genetics/metabolism/*ultrastructure ; DNA, Fungal/metabolism ; Fungal Proteins/genetics/metabolism/*physiology ; Histones/chemistry/genetics/*metabolism ; Humans ; Mutation ; Nuclear Proteins/genetics/metabolism/*physiology ; Nucleosomes/metabolism ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/*genetics/metabolism ; *Saccharomyces cerevisiae Proteins ; Transcription, Genetic ; Transcriptional Elongation Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 102
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    Gene perplexes epilepsy researchers (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, C -- New York, N.Y. -- Science. 1996 Mar 22;271(5256):1672.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596927" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Chromosome Mapping ; Chromosomes, Human, Pair 21/*genetics ; Cystatin B ; Cystatins/*genetics ; Cysteine Proteinase Inhibitors/*genetics ; Epilepsies, Myoclonic/*genetics ; Female ; Humans ; Male ; Mutation ; Pedigree ; RNA, Messenger/genetics/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 103
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    Whose genes are they and how can we identify them? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Botkin, J R -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):903-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966561" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bioethics ; *Confidentiality ; *Genome, Human ; *Human Genome Project ; Humans ; Informed Consent
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 104
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    The instructive role of innate immunity in the acquired immune response (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-05
    Beschreibung: Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fearon, D T -- Locksley, R M -- AI26918/AI/NIAID NIH HHS/ -- AI30663/AI/NIAID NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):50-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600536" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibody Formation ; Antigens/immunology ; Autoimmune Diseases/immunology/therapy ; B-Lymphocytes/immunology ; Cytokines/immunology ; Humans ; Immunity, Active/*immunology ; Immunity, Innate/*immunology ; Immunotherapy ; Infection/immunology/therapy ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 105
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    Is hippocampal cell death a myth? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 1996 Mar 1;271(5253):1229-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638100" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Cell Count ; Cell Death ; Hippocampus/*cytology ; Humans ; Memory Disorders/*etiology ; Neurons/*cytology ; Pyramidal Cells/*cytology ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 106
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    Rethinking AIDS and cancer (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shearer, G M -- Clerici, M -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):163-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927973" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/drug therapy/*therapy ; Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Combined Modality Therapy ; Drug Therapy, Combination ; Humans ; *Immunotherapy ; Neoplasms/drug therapy/*therapy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 107
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    Identification of a human mitotic checkpoint gene: hsMAD2 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-11
    Beschreibung: In Saccharomyces cerevisiae, MAD2 is required for mitotic arrest if the spindle assembly is perturbed. The human homolog of MAD2 was isolated and shown to be a necessary component of the mitotic checkpoint in HeLa cells by antibody electroporation experiments. Human, or Homo sapiens, MAD2 (hsMAD2) was localized at the kinetochore after chromosome condensation but was no longer observed at the kinetochore in metaphase, suggesting that MAD2 might monitor the completeness of the spindle-kinetochore attachment. Finally, T47D, a human breast tumor cell line that is sensitive to taxol and nocodazole, had reduced MAD2 expression and failed to arrest in mitosis after nocodazole treatment. Thus, defects in the mitotic checkpoint may contribute to the sensitivity of certain tumors to mitotic spindle inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Y -- Benezra, R -- P30-CA-08748/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):246-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824189" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Anaphase ; *Calcium-Binding Proteins ; Carrier Proteins/chemistry/*genetics/*metabolism ; Cell Cycle Proteins ; Electroporation ; HeLa Cells ; Humans ; Interphase ; Kinetochores/*metabolism ; Mad2 Proteins ; Metaphase ; *Mitosis ; Molecular Sequence Data ; Nocodazole/pharmacology ; Paclitaxel/pharmacology ; Repressor Proteins ; Spindle Apparatus/drug effects/*metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 108
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    New tumor suppressor found in pancreatic cancer (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, C -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):294.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553063" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Division ; Chromosome Mapping ; Chromosomes, Human, Pair 18 ; Colonic Neoplasms/genetics ; *DNA-Binding Proteins ; Gene Deletion ; *Genes, Tumor Suppressor ; Humans ; Pancreatic Neoplasms/*genetics/pathology ; Proteins/*genetics/physiology ; Smad4 Protein ; *Trans-Activators
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 109
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    Canada considers gene law (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):191.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644817" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Canada ; Embryo Research ; Fees and Charges ; Female ; *Government Regulation ; Humans ; Legislation as Topic ; Oocyte Donation ; *Reproductive Techniques, Assisted ; Research ; *Social Control, Formal ; Spermatozoa ; Surrogate Mothers ; Tissue Donors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 110
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    Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-02
    Beschreibung: The Rho guanosine 5'-triphosphatase (GTPase) cycles between the active guanosine triphosphate (GTP)-bound form and the inactive guanosine diphosphate-bound form and regulates cell adhesion and cytokinesis, but how it exerts these actions is unknown. The yeast two-hybrid system was used to clone a complementary DNA for a protein (designated Rhophilin) that specifically bound to GTP-Rho. The Rho-binding domain of this protein has 40 percent identity with a putative regulatory domain of a protein kinase, PKN. PKN itself bound to GTP-Rho and was activated by this binding both in vitro and in vivo. This study indicates that a serine-threonine protein kinase is a Rho effector and presents an amino acid sequence motif for binding to GTP-Rho that may be shared by a family of Rho target proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watanabe, G -- Saito, Y -- Madaule, P -- Ishizaki, T -- Fujisawa, K -- Morii, N -- Mukai, H -- Ono, Y -- Kakizuka, A -- Narumiya, S -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):645-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Kyoto University Faculty of Medicine, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571126" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Animals ; Cell Line ; Cloning, Molecular ; Enzyme Activation ; GTP Phosphohydrolases/*metabolism ; GTP-Binding Proteins/chemistry/*metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Membrane Proteins/*metabolism ; Mice ; Molecular Sequence Data ; Phosphorylation ; Protein Kinase C/chemistry/*metabolism ; *Protein-Serine-Threonine Kinases ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Signal Transduction ; ras Proteins ; *rho GTP-Binding Proteins ; rhoA GTP-Binding Protein ; rhoB GTP-Binding Protein
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 111
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    Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-25
    Beschreibung: Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from newly synthesized class II histocompatibility molecules, freeing the peptide-binding site for acquisition of antigenic peptides. The mechanism for the selective release of CLIP but not other peptides is unknown. DM was found to enhance the rate of peptide dissociation to an extent directly proportional to the intrinsic rate of peptide dissociation from HLA-DR, regardless of peptide sequence. Thus, CLIP is rapidly released in the presence of DM, because its intrinsic rate of dissociation is relatively high. In antigen presentation, DM has the potential to markedly enhance the rate of peptide exchange, favoring the presentation of peptides with slower intrinsic rates of dissociation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weber, D A -- Evavold, B D -- Jensen, P E -- AI30554/AI/NIAID NIH HHS/ -- AI33614/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):618-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8849454" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Antigen Presentation ; Antigens, Differentiation, B-Lymphocyte/*metabolism ; Binding Sites ; HLA-D Antigens/*metabolism ; HLA-DR Antigens/immunology/*metabolism ; Histocompatibility Antigens Class II/*metabolism ; Humans ; Kinetics ; Molecular Sequence Data ; Peptides/immunology/*metabolism ; Recombinant Fusion Proteins/metabolism
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 112
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    Tumor cells fight back to beat immune system (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966600" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD95/*physiology ; *Apoptosis ; Fas Ligand Protein ; Humans ; Melanoma/chemistry/*immunology ; Membrane Glycoproteins/analysis/*physiology ; Mice ; T-Lymphocytes, Cytotoxic/*cytology/immunology ; Tumor Cells, Cultured ; *Tumor Escape
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 113
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    Locus control region function and heterochromatin-induced position effect variegation (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-23
    Beschreibung: Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration. Transgenic mice carrying an hCD2 mini-gene attached only to the 3' CD2 transcriptional enhancer exhibited variegated expression when the transgene integrated in the centromere. In contrast, mice carrying a transgene with additional 3' sequences showed no variegation even when the latter integrated in centromeric positions. This result suggests that LCRs operate by ensuring an open chromatin configuration and that a short region, with no enhancer activity, functions in the establishment, maintenance, or both of an open chromatin domain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Festenstein, R -- Tolaini, M -- Corbella, P -- Mamalaki, C -- Parrington, J -- Fox, M -- Miliou, A -- Jones, M -- Kioussis, D -- TGT06S01/Telethon/Italy -- TGT95000/Telethon/Italy -- New York, N.Y. -- Science. 1996 Feb 23;271(5252):1123-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599090" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD2/analysis/*genetics ; Centromere/genetics ; Enhancer Elements, Genetic ; *Gene Expression Regulation ; Heterochromatin/*genetics ; Humans ; In Situ Hybridization, Fluorescence ; Mice ; Mice, Transgenic ; *Regulatory Sequences, Nucleic Acid ; T-Lymphocytes/*immunology ; *Transgenes
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 114
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    Safety of hepatitis B vaccine (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, H A -- Mahoney, F J -- Margolis, H S -- New York, N.Y. -- Science. 1996 May 3;272(5262):633-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614813" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Blood-Borne Pathogens ; Child ; Developing Countries ; Hepatitis B/prevention & control ; Hepatitis B Vaccines/*adverse effects/immunology/standards ; Humans ; Infant ; Vaccines, Inactivated/adverse effects/immunology/standards ; Vaccines, Synthetic/immunology ; Virus Diseases/*transmission
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 115
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    Malaria hideout found in new mothers (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633226" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD36/metabolism ; Chondroitin Sulfates/*metabolism ; Erythrocytes/metabolism/*parasitology ; Female ; Genes, Protozoan ; Humans ; Malaria/immunology/*parasitology ; Malaria, Falciparum/immunology/parasitology ; Placenta/*parasitology ; Plasmodium/genetics/*physiology ; Plasmodium falciparum/genetics/physiology ; Pregnancy ; Pregnancy Complications, Parasitic/immunology/*parasitology
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 116
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    Battling heart disease (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, J I -- New York, N.Y. -- Science. 1996 Jul 5;273(5271):15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658181" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; *Cardiovascular Diseases ; Humans ; National Institutes of Health (U.S.)/*economics ; *Research ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 117
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    Bureaucrats save lives (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fink, G R -- New York, N.Y. -- Science. 1996 Mar 1;271(5253):1213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638092" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Administrative Personnel ; DNA, Recombinant ; Government Agencies/*organization & administration ; *Hepatitis B Vaccines ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; Saccharomyces cerevisiae/*genetics ; *Transformation, Genetic ; United States ; Vaccines, Synthetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Transcription factor IIA: a structure with multiple functions (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobson, R H -- Tjian, R -- New York, N.Y. -- Science. 1996 May 10;272(5263):827-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Crystallography, X-Ray ; DNA/*chemistry/metabolism ; DNA-Binding Proteins/*chemistry/metabolism ; Humans ; Models, Molecular ; Nucleic Acid Conformation ; Protein Conformation ; Protein Structure, Secondary ; TATA Box ; TATA-Box Binding Protein ; Transcription Factor TFIIA ; Transcription Factor TFIID ; Transcription Factors/*chemistry/genetics/*metabolism ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Human genetics. New U.K. committee draws fire (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):287.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553059" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bioethics ; *Genetic Testing ; *Genetics, Medical ; Great Britain ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 120
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    Chernobyl research becomes international growth industry (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- Balter, M -- New York, N.Y. -- Science. 1996 Apr 19;272(5260):355-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8602521" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): European Union ; Humans ; International Cooperation ; *Neoplasms, Radiation-Induced ; *Power Plants ; *Radiation Injuries ; *Radioactive Hazard Release ; Research Support as Topic ; Ukraine ; United States ; World Health Organization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 121
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    Streetcar carries evolution modelers around roadblocks (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- New York, N.Y. -- Science. 1996 Mar 8;271(5254):1365-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596907" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; *Game Theory ; Genes ; Genetics, Population ; Humans ; *Models, Biological ; Models, Genetic ; Mutation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 122
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    PIN: an associated protein inhibitor of neuronal nitric oxide synthase (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-01
    Beschreibung: The neurotransmitter functions of nitric oxide are dependent on dynamic regulation of its biosynthetic enzyme, neuronal nitric oxide synthase (nNOS). By means of a yeast two-hybrid screen, a 10-kilodalton protein was identified that physically interacts with and inhibits the activity of nNOS. This inhibitor, designated PIN, appears to be one of the most conserved proteins in nature, showing 92 percent amino acid identity with the nematode and rat homologs. Binding of PIN destabilizes the nNOS dimer, a conformation necessary for activity. These results suggest that PIN may regulate numerous biological processes through its effects on nitric oxide synthase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaffrey, S R -- Snyder, S H -- DA00074/DA/NIDA NIH HHS/ -- GM-07309/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 1;274(5288):774-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8864115" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Carrier Proteins/chemistry/genetics/*metabolism/pharmacology ; Cell Line ; Cyclic GMP/metabolism ; Dimerization ; *Drosophila Proteins ; Dyneins ; Enzyme Inhibitors/chemistry/*metabolism/pharmacology ; Humans ; Molecular Sequence Data ; Molecular Weight ; Neurons/enzymology ; Nitric Oxide Synthase/*antagonists & inhibitors/metabolism ; Rats ; Recombinant Fusion Proteins/metabolism/pharmacology ; Saccharomyces cerevisiae ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 123
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    Modeling HIV concentration during acute AIDS infection (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, S E -- Habeshaw, J A -- Oxford, J S -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1960-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658173" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/immunology/*virology ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology/virology ; HIV-1/*physiology ; Humans ; Macrophages/virology ; *Models, Biological ; Monocytes/virology ; T-Lymphocytes/immunology ; Viremia/virology ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 124
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    Another twist to MHC-peptide recognition (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, I A -- New York, N.Y. -- Science. 1996 May 17;272(5264):973-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638141" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigen Presentation ; Antigens/chemistry/*metabolism ; Antigens, Differentiation, B-Lymphocyte/chemistry/*metabolism ; HLA-DR1 Antigen/chemistry/metabolism ; Histocompatibility Antigens Class II/chemistry/immunology/*metabolism ; Humans ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Mice ; Models, Molecular ; Protein Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 125
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    The image of sociobiology (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, T P -- New York, N.Y. -- Science. 1996 Nov 1;274(5288):703-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966549" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Behavior ; *Biological Science Disciplines ; Humans ; *Social Sciences
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 126
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    Environmental estrogens: can two "alrights" make a wrong? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simons, S S Jr -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1451.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Steroid Hormones Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. steroids@helix.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633235" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding, Competitive ; Drug Synergism ; Environmental Pollutants/metabolism/*pharmacology ; Estradiol/metabolism ; Estrogens, Non-Steroidal/metabolism/*pharmacology ; Humans ; Insecticides/metabolism/*pharmacology ; Polychlorinated Biphenyls/*pharmacology ; Receptors, Estrogen/drug effects/metabolism ; Saccharomyces cerevisiae/genetics/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 127
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    Will a twist of viral fate lead to a new cancer treatment? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1996 Oct 18;274(5286):342-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927990" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenovirus E1B Proteins/*genetics/metabolism ; Adenoviruses, Human/genetics/*physiology ; Animals ; Clinical Trials, Phase I as Topic ; Cytopathogenic Effect, Viral ; Genes, Viral ; *Genes, p53 ; Head and Neck Neoplasms/*therapy/virology ; Humans ; Mice ; Mutation ; Neoplasm Transplantation ; Neoplasms, Experimental/*therapy/virology ; Tumor Suppressor Protein p53/metabolism ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 128
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    EMF report: is there consensus? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Florig, K -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1449-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966609" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Electromagnetic Fields/*adverse effects ; Humans ; Neoplasms, Radiation-Induced/*etiology ; Probability ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 129
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    Drug's link to genes reveals estrogen's many sides (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1171.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8787121" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bone and Bones/drug effects/metabolism ; Estrogen Antagonists/metabolism/*pharmacology ; Estrogens/metabolism/pharmacology ; Female ; Gene Expression Regulation ; Humans ; Piperidines/metabolism/*pharmacology ; Raloxifene Hydrochloride ; Receptors, Estrogen/metabolism ; Regulatory Sequences, Nucleic Acid ; Transforming Growth Factor beta/*genetics ; Uterus/drug effects/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 130
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    AIDS politics (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, C H -- New York, N.Y. -- Science. 1996 Aug 16;273(5277):859.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8711470" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acquired Immunodeficiency Syndrome ; Humans ; National Institutes of Health (U.S.) ; *Research ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 131
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    Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-20
    Beschreibung: The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holmes, T C -- Fadool, D A -- Ren, R -- Levitan, I B -- F32 NS009952/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2089-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953041" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Cell Line ; Cloning, Molecular ; Humans ; Kv1.5 Potassium Channel ; Molecular Sequence Data ; Myocardium/chemistry ; Oncogene Protein pp60(v-src)/metabolism ; Patch-Clamp Techniques ; Phosphorylation ; Phosphotyrosine/metabolism ; Potassium Channels/chemistry/*metabolism ; *Potassium Channels, Voltage-Gated ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Transfection ; src Homology Domains/*physiology ; src-Family Kinases/chemistry/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 132
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    Molecular pathways controlling heart development (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, E N -- Srivastava, D -- New York, N.Y. -- Science. 1996 May 3;272(5262):671-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, 75235-9148, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614825" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; *Gene Expression Regulation, Developmental ; Genes ; Genes, Regulator ; Heart/*embryology ; Heart Conduction System/embryology ; Heart Defects, Congenital/embryology/*genetics/pathology ; Humans ; Morphogenesis ; Mutation ; Myocardium/cytology ; Neural Crest/cytology ; Transcription Factors/physiology ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 133
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    Activists vote $14 million for research (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Nov 15;274(5290):1077.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966582" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Breast Neoplasms ; Budgets ; Female ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; Research ; *Research Support as Topic ; United States ; United States Dept. of Health and Human Services
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 134
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    Battle ends in $21 million settlement (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):911.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966568" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biotechnology/*legislation & jurisprudence ; Confidentiality ; Humans ; Interleukin-1/*genetics ; Patents as Topic/*legislation & jurisprudence ; Peer Review, Research/*legislation & jurisprudence ; Sequence Analysis, DNA
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 135
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    Rho returns: its targets in focal adhesions (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bussey, H -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):203.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, McGill University, Montreal, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8668997" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/*metabolism ; Fungal Proteins/metabolism ; GTP Phosphohydrolases/metabolism ; GTP-Binding Proteins/*metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Myosin-Light-Chain Phosphatase ; Myosins/*metabolism ; Phosphoprotein Phosphatases/antagonists & inhibitors/metabolism ; Phosphorylation ; Polysaccharides/biosynthesis ; Protein-Serine-Threonine Kinases/*metabolism ; Yeasts/metabolism ; *rho GTP-Binding Proteins ; rho-Associated Kinases ; rhoA GTP-Binding Protein
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 136
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    Fraud strikes top genome lab (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):908-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966566" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chromosome Inversion ; *Chromosomes, Human, Pair 16 ; Genetic Research ; History, 20th Century ; Human Genome Project ; Humans ; Leukemia, Myelomonocytic, Acute/*genetics ; Mice ; National Institutes of Health (U.S.) ; *Scientific Misconduct ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 137
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    Activation of estrogen receptors (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joffe, M -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1285-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966591" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Drug Synergism ; Estradiol/metabolism ; Estrogens, Non-Steroidal/metabolism/*pharmacology ; Humans ; Insecticides/metabolism/*pharmacology ; Polychlorinated Biphenyls/metabolism/*pharmacology ; Rats ; Receptors, Estrogen/drug effects/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 138
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    The genome project's conscience (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):488-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927996" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bioethics ; Budgets ; Cystic Fibrosis/genetics ; Databases, Nucleic Acid ; *Ethical Review ; Ethicists ; Federal Government ; Genetic Testing ; *Genetics, Medical ; Government Agencies/economics ; Heterozygote Detection ; *Human Genome Project/economics ; Humans ; Informed Consent ; Insurance, Health ; National Institutes of Health (U.S.)/economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 139
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    The future of the behavioral and social sciences (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, P M -- Torrey, B B -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):611-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGeary and Smith, Washington, DC 20024, USA. psmith@nas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571121" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Behavioral Sciences/*trends ; Data Collection ; Financing, Government ; Forecasting ; Humans ; International Cooperation ; Longitudinal Studies ; Nonlinear Dynamics ; Public Policy ; *Research ; Research Support as Topic ; Social Sciences/*trends ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 140
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    Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-07
    Beschreibung: Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum-infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound to purified chondroitin sulfate A (CSA) but not to other extracellular matrix proteins or to other known IRBC receptors. IRBCs from nonpregnant donors did not bind to CSA. Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and this adhesion was competitively inhibited by purified CSA. Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fried, M -- Duffy, P E -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1502-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Army Medical Research Unit-Kenya, Kisumu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633247" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adhesiveness ; Adolescent ; Adult ; Animals ; Antigens, CD36/metabolism ; Chondroitin Lyases/pharmacology ; Chondroitin Sulfates/*metabolism ; Erythrocytes/metabolism/*parasitology ; Extracellular Matrix Proteins/metabolism ; Female ; Humans ; Malaria, Falciparum/*parasitology ; Placenta/*parasitology ; Plasmodium falciparum/*physiology ; Pregnancy ; Pregnancy Complications, Parasitic/*parasitology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 141
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    Tilting against a major theory of movement control (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600532" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Arm/*physiology ; Biomechanical Phenomena ; Brain/*physiology ; Elbow Joint/physiology ; Feedback ; Humans ; Movement/*physiology ; Muscle Contraction ; Muscle, Skeletal/physiology ; Psychomotor Performance/*physiology ; Shoulder Joint/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 142
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    Serious setback for Patarroyo vaccine (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-09-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1996 Sep 20;273(5282):1652.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8830407" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Animals ; Child ; Colombia ; Controlled Clinical Trials as Topic ; Humans ; *Malaria Vaccines/immunology ; Malaria, Falciparum/*prevention & control ; Plasmodium falciparum/*immunology ; Protozoan Proteins/*immunology ; *Recombinant Proteins ; Thailand ; Vaccines, Synthetic/immunology ; World Health Organization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 143
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    Psychobiology and biopsychology (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyder, M -- New York, N.Y. -- Science. 1996 Oct 18;274(5286):326.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927982" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; National Institutes of Health (U.S.)/*organization & administration ; *Neurosciences ; *Peer Review, Research ; Research ; *Substance-Related Disorders ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 144
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    Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-29
    Beschreibung: The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel regulated by protein kinase A and adenosine triphosphate (ATP). Loss of CFTR-mediated chloride ion conductance from the apical plasma membrane of epithelial cells is a primary physiological lesion in cystic fibrosis. CFTR has also been suggested to function an an ATP channel, although the size of the ATP anion is much larger than the estimated size of the CFTR pore. ATP was not conducted through CFTR in intact organs, polarized human lung cell lines, stably transfected mammalian cell lines, or planar lipid bilayers reconstituted with CFTR protein. These findings suggest that ATP permeation through the CFTR is unlikely to contribute to the normal function of CFTR or to the pathogenesis of cystic fibrosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, M M -- Quinton, P M -- Haws, C -- Wine, J J -- Grygorczyk, R -- Tabcharani, J A -- Hanrahan, J W -- Gunderson, K L -- Kopito, R R -- DK43994/DK/NIDDK NIH HHS/ -- DK45913/DK/NIDDK NIH HHS/ -- HL42368/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1996 Mar 29;271(5257):1876-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biomedical Sciences, University of California, Riverside, 92521, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596959" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/*metabolism ; Animals ; CHO Cells ; Cell Line ; Cell Membrane/metabolism ; Cell Polarity ; Chlorides/metabolism ; Cricetinae ; Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism ; Humans ; Lipid Bilayers/metabolism ; Lung/cytology/metabolism ; Patch-Clamp Techniques ; Recombinant Proteins/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 145
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    Latest Homo erectus of Java: potential contemporaneity with Homo sapiens in southeast Asia (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-13
    Beschreibung: Hominid fossils from Ngandong and Sambungmacan, Central Java, are considered the most morphologically advanced representatives of Homo erectus. Electron spin resonance (ESR) and mass spectrometric U-series dating of fossil bovid teeth collected from the hominid-bearing levels at these sites gave mean ages of 27 +/- 2 to 53.3 +/- 4 thousand years ago; the range in ages reflects uncertainties in uranium migration histories. These ages are 20,000 to 400,000 years younger than previous age estimates for these hominids and indicate that H. erectus may have survived on Java at least 250,000 years longer than on the Asian mainland, and perhaps 1 million years longer than in Africa. The new ages raise the possibility that H. erectus overlapped in time with anatomically modern humans (H. sapiens) in Southeast Asia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swisher, C C 3rd -- Rink, W J -- Anton, S C -- Schwarcz, H P -- Curtis, G H -- Suprijo, A -- Widiasmoro -- New York, N.Y. -- Science. 1996 Dec 13;274(5294):1870-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Berkeley Geochronology Center, 2455 Ridge Road, Berkeley, CA 94709 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8943192" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Animals ; Asia, Southeastern ; Australia ; Cattle ; Dental Enamel/chemistry ; Dentin/chemistry ; Electron Spin Resonance Spectroscopy ; *Fossils ; History, Ancient ; *Hominidae ; Humans ; Indonesia ; Mass Spectrometry ; Paleodontology ; *Paleontology ; Uranium/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 146
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    AIDS vaccine trial disappointing (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1996 Apr 19;272(5260):341.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8602519" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/*therapeutic use ; Controlled Clinical Trials as Topic ; Disease Progression ; HIV Infections/immunology/*therapy ; Humans ; Multicenter Studies as Topic ; Vaccines, Synthetic/therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 147
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    AIDS: a global response (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piot, P -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1855.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658147" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/drug therapy/*epidemiology/prevention & ; control ; Developing Countries ; *Disease Outbreaks ; *Global Health ; Humans ; International Cooperation ; Research ; United Nations
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 148
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    Electrons and sex (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abramson, P -- Pinkerton, S D -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1155-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8787116" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Culture ; *Data Collection ; Female ; Humans ; Male ; Sampling Studies ; *Sexual Behavior
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 149
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    HIV therapeutics (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richman, D D -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1886-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉San Diego Veterans Affairs Medical Center, La Jolla, California 92092-0679, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658159" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antiviral Agents/*therapeutic use ; Drug Therapy, Combination ; HIV/*drug effects/physiology ; HIV Infections/*drug therapy/virology ; Humans ; Lymphoid Tissue/virology ; RNA, Viral/blood ; Viremia/*drug therapy/virology ; Virus Replication/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 150
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    Investigators detail HIV's fatal handshake (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8928003" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, CD4/*metabolism ; Cell Membrane/metabolism/virology ; HIV/*metabolism ; HIV Envelope Protein gp120/metabolism ; HIV Envelope Protein gp41/metabolism ; Humans ; Membrane Proteins/*metabolism ; Protein Conformation ; Receptors, CCR5 ; Receptors, CXCR4 ; Receptors, Cytokine/metabolism ; Receptors, HIV/*metabolism ; T-Lymphocytes/*virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 151
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    Pharmaceuticals based on biotechnology (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, P H -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):719.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8701317" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biotechnology/economics ; Databases, Factual ; *Drug Industry/economics ; Genome, Human ; Humans ; Research ; *Technology, Pharmaceutical/economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 152
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    Misfolding the way to disease (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1996 Mar 15;271(5255):1493-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599100" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*metabolism ; Amino Acid Sequence ; Amyloid beta-Peptides/*chemistry/metabolism ; Amyloid beta-Protein Precursor/chemistry/genetics/metabolism ; Amyloidosis/*metabolism ; Animals ; Brain Chemistry ; Humans ; Prealbumin/chemistry/genetics ; Prion Diseases/*metabolism ; *Protein Folding
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 153
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    Immunology taught by Darwin (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKean, K A -- Nunney, L -- Zuk, M -- New York, N.Y. -- Science. 1996 May 3;272(5262):634-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614814" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Humans ; Immune System/*physiology ; Immune Tolerance ; Selection, Genetic ; Self Tolerance ; Virus Diseases/*immunology ; Viruses/*immunology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 154
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    Controls on DNA could impact research (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1996 Jul 19;273(5273):299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644818" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Confidentiality ; *Databases, Factual ; *Databases, Nucleic Acid ; Employment ; Federal Government ; *Genetic Privacy ; *Genetic Testing ; Genetics, Population ; Government ; Government Regulation ; Human Genome Project ; Humans ; Informed Consent ; Insurance ; *Legislation as Topic ; *Pedigree ; Politics ; Prejudice ; *Privacy ; Social Control, Formal ; Tissue Donors ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 155
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    The marketplace of HIV/AID$ (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1880-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658155" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/*economics ; Acquired Immunodeficiency Syndrome/diagnosis/drug therapy/*economics/prevention & ; control ; Antiviral Agents/*economics ; *Hiv ; HIV Protease Inhibitors/economics ; Humans ; *Investments ; Reverse Transcriptase Inhibitors/economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 156
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    Should non-peer-reviewed raw DNA sequence data release be forced on the scientific community? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adams, M D -- Venter, J C -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):534-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8928007" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Base Sequence ; *Computer Communication Networks ; DNA/*genetics ; Databases, Factual ; *Genome ; Genome, Human ; Human Genome Project ; Humans ; *Information Management ; Peer Review, Research ; Publishing ; Quality Control ; Sequence Analysis, DNA
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 157
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    Tobacco research (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glenn, J F -- New York, N.Y. -- Science. 1996 Jul 12;273(5272):167.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8668987" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Heart Diseases/epidemiology/etiology ; Humans ; *Industry ; *Plants, Toxic ; *Publishing ; *Research Support as Topic ; Smoking/adverse effects ; *Tobacco
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 158
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    Immunological memory and protective immunity: understanding their relation (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-05
    Beschreibung: The immune system can remember, sometimes for a lifetime, the identity of a pathogen. Understanding how this is accomplished has fascinated immunologists and microbiologists for many years, but there is still considerable debate regarding the mechanisms by which long-term immunity is maintained. Some of the controversy stems from a failure to distinguish between effector and memory cells and to define their roles in conferring protection against disease. Here the current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmed, R -- Gray, D -- AI-30048/AI/NIAID NIH HHS/ -- NS-21496/NS/NINDS NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):54-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600537" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibody Formation ; Antigens/immunology ; B-Lymphocytes/cytology/*immunology ; CD4-Positive T-Lymphocytes/cytology/immunology ; CD8-Positive T-Lymphocytes/cytology/immunology ; Cell Differentiation ; Cell Lineage ; Humans ; Immunologic Memory/*immunology ; Infection/immunology ; Lymphocyte Activation ; Plasma Cells/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/cytology/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 159
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    Risks from low doses of radiation: continued (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, M -- New York, N.Y. -- Science. 1996 Aug 2;273(5275):562-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8701303" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Dose-Response Relationship, Radiation ; Humans ; Neoplasms, Radiation-Induced/*etiology ; Radiation Dosage ; Radiation Injuries/*etiology ; Risk Assessment
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 160
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    AIDS trials take on peer review (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 Jan 5;271(5245):20-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539588" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*drug therapy ; Antiviral Agents/*therapeutic use ; Clinical Trials as Topic/*economics ; Financing, Government ; Humans ; Multicenter Studies as Topic/economics ; *National Institutes of Health (U.S.)/economics ; *Peer Review, Research ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 161
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    Alzheimer's original patient (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amaducci, L -- New York, N.Y. -- Science. 1996 Oct 18;274(5286):328.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8927984" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*history/pathology ; Brain/pathology ; Diagnosis, Differential ; History, 20th Century ; Humans ; Leukodystrophy, Metachromatic/history/pathology ; Neurofibrillary Tangles/pathology ; Spinal Cord/pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 162
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    The molecular biology of axon guidance (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-15
    Beschreibung: Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tessier-Lavigne, M -- Goodman, C S -- New York, N.Y. -- Science. 1996 Nov 15;274(5290):1123-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8895455" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/*physiology ; Biological Evolution ; Cell Adhesion Molecules, Neuronal/physiology ; Cell Communication ; Cell Movement ; Humans ; Ligands ; Nerve Growth Factors/physiology ; Nerve Tissue Proteins/physiology ; Nervous System/*embryology ; Neural Pathways/*embryology ; Receptors, Cell Surface/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 163
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    Women alcoholics at Bellevue, 1918-1919 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roizen, R -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1450-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966611" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alcoholism/epidemiology/*history ; Female ; History, 20th Century ; Humans ; Male ; New York/epidemiology ; Patient Admission
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 164
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    Cholesterol modification of hedgehog signaling proteins in animal development (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-11
    Beschreibung: Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for patterning a variety of structures in animal embryogenesis. During biosynthesis, Hh undergoes an autocleavage reaction, mediated by its carboxyl-terminal domain, that produces a lipid-modified amino-terminal fragment responsible for all known Hh signaling activity. Here it is reported that cholesterol is the lipophilic moiety covalently attached to the amino-terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase. This use of cholesterol to modify embryonic signaling proteins may account for some of the effects of perturbed cholesterol biosynthesis on animal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, J A -- Young, K E -- Beachy, P A -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):255-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824192" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cells, Cultured ; Cholesterol/*metabolism ; Dithiothreitol/pharmacology ; Drosophila ; *Drosophila Proteins ; *Embryonic Induction ; Embryonic and Fetal Development ; Hedgehog Proteins ; Humans ; Protein Processing, Post-Translational ; Proteins/genetics/*metabolism ; Signal Transduction ; *Trans-Activators
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 165
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    Varmus's RAC attack worries Congress (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1996 Jul 5;273(5271):21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644814" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Advisory Committees ; Ethical Review ; Ethics ; Federal Government ; *Genetic Therapy ; Government ; Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; Politics ; *Public Policy ; Social Control, Formal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 166
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    The representation of brightness in primary visual cortex (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-23
    Beschreibung: Although neurons in primary visual cortex are sensitive to the spatial distribution and intensity of light, their responses have not been thought to correlate with the perception of brightness. Indeed, primary visual cortex is often described as an initial processing stage that sends information to higher cortical areas where perception of brightness, color, and form occurs. However, a significant percentage of neurons in primary visual cortex were shown to respond in a manner correlated with perceived brightness, rather than responding strictly to the light level in the receptive fields of the cells. This finding suggests that even at the first stage of visual cortical processing, spatial integration of information yields perceptual qualities that are only indirectly related to the pattern of illumination of the retina.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rossi, A F -- Rittenhouse, C D -- Paradiso, M A -- New York, N.Y. -- Science. 1996 Aug 23;273(5278):1104-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688096" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cats ; Color Perception ; *Contrast Sensitivity ; Form Perception ; Humans ; Light ; Neurons/physiology ; Visual Cortex/*physiology ; *Visual Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 167
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    Cancer risk of low-level exposure (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, M -- New York, N.Y. -- Science. 1996 Mar 29;271(5257):1821-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgical and Radiological Sciences, University of California, Davis 95616-8742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Carcinogens ; Child ; Dose-Response Relationship, Radiation ; Humans ; Neoplasms/*chemically induced ; *Neoplasms, Radiation-Induced ; Radiation Dosage ; Risk Assessment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 168
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    SIV transmission. Monkey study prompts high-level public health response (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 May 10;272(5263):805.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629005" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Contraceptive Agents, Female/adverse effects ; Disease Models, Animal ; Epithelium/drug effects/virology ; Female ; HIV Infections/transmission/virology ; Haplorhini ; Humans ; Levonorgestrel/adverse effects ; Medroxyprogesterone Acetate/adverse effects ; Progesterone/*pharmacology ; Risk Factors ; Simian Acquired Immunodeficiency Syndrome/*transmission/virology ; Simian Immunodeficiency Virus/physiology ; Vagina/*drug effects/virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 169
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    Diffusional mobility of Golgi proteins in membranes of living cells (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-09
    Beschreibung: The mechanism by which Golgi membrane proteins are retained within the Golgi complex in the midst of a continuous flow of protein and lipid is not yet understood. The diffusional mobilities of mammalian Golgi membrane proteins fused with green fluorescent protein from Aequorea victoria were measured in living HeLa cells with the fluorescence photobleaching recovery technique. The diffusion coefficients ranged from 3 x 10(-9) square centimeters per second to 5 x 10(-9) square centimeters per second, with greater than 90 percent of the chimeric proteins mobile. Extensive lateral diffusion of the chimeric proteins occurred between Golgi stacks. Thus, the chimeras diffuse rapidly and freely in Golgi membranes, which suggests that Golgi targeting and retention of these molecules does not depend on protein immobilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cole, N B -- Smith, C L -- Sciaky, N -- Terasaki, M -- Edidin, M -- Lippincott-Schwartz, J -- R37 AI14584/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):797-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670420" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aluminum Compounds/pharmacology ; Diffusion ; Endoplasmic Reticulum/metabolism ; Fluorides/pharmacology ; Golgi Apparatus/*metabolism ; Green Fluorescent Proteins ; HeLa Cells ; Humans ; Intracellular Membranes/metabolism ; Luminescent Proteins ; Mannosidases/*metabolism ; Membrane Proteins/*metabolism ; Microscopy, Confocal ; Mutation ; N-Acetyllactosamine Synthase/*metabolism ; Receptors, Peptide/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 170
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    Nucleocytoplasmic transport (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-03-15
    Beschreibung: Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation requires energy, and for the import process this energy is at least partly consumed by the action of the small guanosine triphosphatase Ran. In the first half of the review, some of the well-established general background information on nucleocytoplasmic transport is discussed. The second half describes recent information on the mechanistic details of nuclear import and export as well as major unresolved issues such as how directionality is conferred on either import or export. The whole review is slanted toward discussion of metazoan cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorlich, D -- Mattaj, I W -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1996 Mar 15;271(5255):1513-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome/Cancer Research Campaign Institute, Cambridge, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599106" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Biological Transport, Active ; Cell Nucleus/*metabolism ; Cytoplasm/*metabolism ; GTP-Binding Proteins/metabolism ; Humans ; Karyopherins ; Molecular Sequence Data ; Nuclear Proteins/metabolism ; Protein Sorting Signals/metabolism ; Proteins/*metabolism ; RNA/*metabolism ; RNA Cap-Binding Proteins ; RNA-Binding Proteins/metabolism ; ran GTP-Binding Protein
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 171
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    Results on new AIDS drugs bring cautious optimism (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1996 Feb 9;271(5250):755-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8628987" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*drug therapy/virology ; Antiviral Agents/*therapeutic use ; CD4 Lymphocyte Count ; Clinical Trials as Topic ; Drug Therapy, Combination ; HIV/*drug effects/physiology ; HIV Protease Inhibitors/*therapeutic use ; Humans ; Indinavir ; Pyridines/therapeutic use ; RNA, Viral/blood ; Ritonavir ; Thiazoles/therapeutic use ; Valine/analogs & derivatives/therapeutic use ; Viremia
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 172
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    Out damned CLIP! Out, I say! (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roche, P A -- New York, N.Y. -- Science. 1996 Oct 25;274(5287):526-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. rochep@dc10a.nci.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8928005" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigen Presentation ; Antigens/immunology/*metabolism ; Antigens, Differentiation, B-Lymphocyte/*metabolism ; HLA-D Antigens/*metabolism ; Histocompatibility Antigens Class II/immunology/*metabolism ; Humans ; Hydrogen Bonding ; Models, Immunological ; Peptides/immunology/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 173
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    NCI: a lab scientist's view, from the director's office (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-09-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klausner, R -- New York, N.Y. -- Science. 1996 Sep 6;273(5280):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8801626" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome ; Administrative Personnel ; Humans ; National Institutes of Health (U.S.)/economics/*organization & administration ; *Neoplasms/genetics ; *Research ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 174
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    Temporal processing deficits of language-learning impaired children ameliorated by training (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-05
    Beschreibung: Children with language-based learning impairments (LLIs) have major deficits in their recognition of some rapidly successive phonetic elements and nonspeech sound stimuli. In the current study, LLI children were engaged in adaptive training exercises mounted as computer "games" designed to drive improvements in their "temporal processing" skills. With 8 to 16 hours of training during a 20-day period, LLI children improved markedly in their abilities to recognize brief and fast sequences of nonspeech and speech stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merzenich, M M -- Jenkins, W M -- Johnston, P -- Schreiner, C -- Miller, S L -- Tallal, P -- New York, N.Y. -- Science. 1996 Jan 5;271(5245):77-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉W. M. Keck Center for Integrative Neurosciences, University of California, San Francisco 94143-0732, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Child, Preschool ; Female ; Humans ; Language Disorders/*therapy ; *Language Therapy ; Learning Disorders/*therapy ; Male ; *Software ; Speech Perception ; *Video Games
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 175
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    How proteolysis drives the cell cycle (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-06
    Beschreibung: Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity-by degrading CDK activators or inhibitors-and also how proteolysis may directly trigger the transition from metaphase to anaphase. Proteolysis during the cell cycle is mediated by two distinct ubiquitin-conjugation pathways. One pathway, requiring CDC34, initiates DNA replication by degrading a CDK inhibitor. The second pathway, involving a large protein complex called the anaphase-promoting complex or cyclosome, initiates chromosome segregation and exit from mitosis by degrading anaphase inhibitors and mitotic cyclins. Proteolysis therefore drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, R W -- Deshaies, R J -- Peters, J M -- Kirschner, M W -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1652-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939846" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anaphase ; Anaphase-Promoting Complex-Cyclosome ; Animals ; *Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Division ; Cyclin-Dependent Kinases/antagonists & inhibitors/*metabolism ; Cyclins/metabolism ; Enzyme Inhibitors/metabolism ; Fungal Proteins/metabolism ; Fungi/cytology/metabolism ; G1 Phase ; Humans ; Ligases/metabolism ; Mitosis ; Proteins/*metabolism ; S Phase ; Ubiquitin-Conjugating Enzymes ; *Ubiquitin-Protein Ligase Complexes ; Ubiquitin-Protein Ligases ; Ubiquitins/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 176
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    Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-09-06
    Beschreibung: A chimeric oligonucleotide composed of DNA and modified RNA residues was used to direct correction of the mutation in the hemoglobin betaS allele. After introduction of the chimeric molecule into lymphoblastoid cells homozygous for the betaS mutation, there was a detectable level of gene conversion of the mutant allele to the normal sequence. The efficient and specific conversion directed by chimeric molecules may hold promise as a therapeutic method for the treatment of genetic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cole-Strauss, A -- Yoon, K -- Xiang, Y -- Byrne, B C -- Rice, M C -- Gryn, J -- Holloman, W K -- Kmiec, E B -- New York, N.Y. -- Science. 1996 Sep 6;273(5280):1386-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703073" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Anemia, Sickle Cell/*genetics/therapy ; Base Sequence ; Cells, Cultured ; *Gene Conversion ; Genetic Therapy ; Globins/genetics ; Hemoglobin, Sickle/*genetics ; Humans ; Lymphocytes ; Molecular Sequence Data ; Oligodeoxyribonucleotides/*genetics ; Oligoribonucleotides/*genetics ; Point Mutation ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; *Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 177
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    Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: Mutations in the p53 tumor suppressor are among the most frequently observed genetic alterations in human cancer and map to the 200-amino acid core domain of the protein. The core domain contains the sequence-specific DNA binding activity and the in vitro 53BP2 protein binding activity of p53. The crystal structure of the p53 core domain bound to the 53BP2 protein, which contains an SH3 (Src homology 3) domain and four ankyrin repeats, revealed that (i) the SH3 domain binds the L3 loop of p53 in a manner distinct from that of previously characterized SH3-polyproline peptide complexes, and (ii) an ankyrin repeat, which forms an L-shaped structure consisting of a beta hairpin and two alpha helices, binds the L2 loop of p53. The structure of the complex shows that the 53BP2 binding site on the p53 core domain consists of evolutionarily conserved regions that are frequently mutated in cancer and that it overlaps the site of DNA binding. The six most frequently observed p53 mutations disrupt 53BP2 binding in vitro. The structure provides evidence that the 53BP2-p53 complex forms in vivo and may have a critical role in the p53 pathway of tumor suppression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorina, S -- Pavletich, N P -- CA65698/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):1001-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8875926" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Ankyrins/*chemistry ; Apoptosis Regulatory Proteins ; Binding Sites ; Carrier Proteins/*chemistry/metabolism ; Crystallography, X-Ray ; DNA/metabolism ; Humans ; Hydrogen Bonding ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Neoplasms/genetics ; Protein Binding ; *Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry/metabolism ; Tumor Suppressor Protein p53/*chemistry/genetics/metabolism ; *src Homology Domains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 178
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    The aging immune system: primer and prospectus (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-05
    Beschreibung: Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, R A -- New York, N.Y. -- Science. 1996 Jul 5;273(5271):70-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Michigan School of Medicine, University of Michigan Institute of Gerontology, Ann Arbor, 48109-0642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658199" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Aged, 80 and over ; Aging/*immunology ; Animals ; Antibody Formation ; Antigen-Presenting Cells/immunology ; B-Lymphocytes/immunology ; Cytotoxicity, Immunologic ; Disease Susceptibility/immunology ; Humans ; Immune System/*immunology ; Immunologic Memory ; Killer Cells, Natural/immunology ; Longevity ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 179
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    A mouse model of familial hypertrophic cardiomyopathy (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-03
    Beschreibung: A mouse model of familial hypertrophic cardiomyopathy (FHC) was generated by the introduction of an Arg 403 --〉 Gln mutation into the alpha cardiac myosin heavy chain (MHC) gene. Homozygous alpha MHC 403/403 mice died 7 days after birth, and sedentary heterozygous alpha MHC 403/+ mice survived for 1 year. Cardiac histopathology and dysfunction in the alpha MHC 403/+ mice resembled human FHC. Cardiac dysfunction preceded histopathologic changes, and myocyte disarray, hypertrophy, and fibrosis increased with age. Young male alpha MHC 403/+ mice showed more evidence of disease than did their female counterparts. Preliminary results suggested that exercise capacity may have been compromised in the alpha MHC 403/+ mice. This mouse model may help to define the natural history of FHC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geisterfer-Lowrance, A A -- Christe, M -- Conner, D A -- Ingwall, J S -- Schoen, F J -- Seidman, C E -- Seidman, J G -- New York, N.Y. -- Science. 1996 May 3;272(5262):731-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614836" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cardiac Output ; Cardiomyopathy, Hypertrophic/*genetics/pathology/physiopathology ; *Disease Models, Animal ; Female ; Gene Transfer Techniques ; Heart/*physiopathology ; Heterozygote ; Homozygote ; Humans ; Male ; Mice ; Mice, Mutant Strains ; Molecular Sequence Data ; Mutation ; Myocardium/chemistry/*pathology ; Myosin Heavy Chains/*genetics ; Physical Exertion ; Sex Characteristics ; Ventricular Function, Left
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 180
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    A new receptor for growth hormone-release peptide (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conn, P M -- Bowers, C Y -- New York, N.Y. -- Science. 1996 Aug 16;273(5277):923.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oregon Regional Primate Research Center, Beaverton, OR 97006-3499, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8711477" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cloning, Molecular ; Growth Hormone/pharmacology/*secretion ; Growth Hormone-Releasing Hormone/metabolism ; Hormones/metabolism/pharmacology ; Humans ; Hypothalamus/metabolism ; Insulin-Like Growth Factor I/analysis ; Oligopeptides/*metabolism/pharmacology ; Receptors, Cell Surface/chemistry/*metabolism ; *Receptors, G-Protein-Coupled ; Receptors, Ghrelin ; Receptors, Neuropeptide/metabolism ; Receptors, Pituitary Hormone-Regulating Hormone/metabolism ; Recombinant Proteins/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 181
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    Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-30
    Beschreibung: Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to chromosome 1q21. Cathepsin K, a cysteine protease gene that is highly expressed in osteoclasts, localized to the pycnodysostosis region. Nonsense, missense, and stop codon mutations in the gene encoding cathepsin K were identified in patients. Transient expression of complementary DNA containing the stop codon mutation resulted in messenger RNA but no immunologically detectable protein. Thus, pycnodysostosis results from gene defects in a lysosomal protease with highest expression in osteoclasts. These findings suggest that cathepsin K is a major protease in bone resorption, providing a possible rationale for the treatment of disorders such as osteoporosis and certain forms of arthritis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelb, B D -- Shi, G P -- Chapman, H A -- Desnick, R J -- R01 DK31775/DK/NIDDK NIH HHS/ -- R01 HL44816/HL/NHLBI NIH HHS/ -- R37 DK34045/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1236-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics and Division of Pediatric Cardiology, Mount Sinai School of Medicine, New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703060" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Bone Matrix/metabolism ; Bone Resorption ; Cathepsin K ; Cathepsins/deficiency/*genetics/metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 1 ; Codon, Terminator ; Dinucleoside Phosphates/genetics ; Humans ; Lysosomal Storage Diseases/enzymology/*genetics ; Lysosomes/*enzymology ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; Osteochondrodysplasias/enzymology/*genetics ; Osteoclasts/*enzymology ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 182
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    PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-31
    Beschreibung: A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in three PKD2 families. The predicted 968-amino acid sequence of the PKD2 gene product has six transmembrane spans with intracellular amino- and carboxyl-termini. The PKD2 protein has amino acid similarity with PKD1, the Caenorhabditis elegans homolog of PKD1, and the family of voltage-activated calcium (and sodium) channels, and it contains a potential calcium-binding domain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mochizuki, T -- Wu, G -- Hayashi, T -- Xenophontos, S L -- Veldhuisen, B -- Saris, J J -- Reynolds, D M -- Cai, Y -- Gabow, P A -- Pierides, A -- Kimberling, W J -- Breuning, M H -- Deltas, C C -- Peters, D J -- Somlo, S -- DK02015/DK/NIDDK NIH HHS/ -- DK48383/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 May 31;272(5266):1339-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Renal Division, Department of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650545" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Caenorhabditis elegans/chemistry/genetics ; Calcium Channels/chemistry/genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 4 ; Cloning, Molecular ; Consensus Sequence ; Crystallography, X-Ray ; Female ; Glycosylation ; Humans ; Male ; Membrane Proteins/chemistry/*genetics/physiology ; Molecular Sequence Data ; Mutation ; Pedigree ; Phenotype ; Polycystic Kidney, Autosomal Dominant/*genetics ; Polymorphism, Single-Stranded Conformational ; Proteins/chemistry/genetics ; Sodium Channels/chemistry/genetics ; TRPP Cation Channels
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 183
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    Small-conductance, calcium-activated potassium channels from mammalian brain (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-09-20
    Beschreibung: Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohler, M -- Hirschberg, B -- Bond, C T -- Kinzie, J M -- Marrion, N V -- Maylie, J -- Adelman, J P -- New York, N.Y. -- Science. 1996 Sep 20;273(5282):1709-14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vollum Institute, L-474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA. J. Maylie, Department of Obstetrics and Gyne.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8781233" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antisense Elements (Genetics) ; Apamin/pharmacology ; *Brain Chemistry ; Calcium/*metabolism/pharmacology ; Cloning, Molecular ; Electric Conductivity ; Female ; Humans ; Membrane Potentials ; Molecular Sequence Data ; Neurons/*physiology ; Oocytes ; Patch-Clamp Techniques ; Potassium/metabolism ; Potassium Channel Blockers ; Potassium Channels/analysis/chemistry/*physiology ; *Potassium Channels, Calcium-Activated ; RNA, Messenger/analysis/genetics ; Rats ; Rats, Sprague-Dawley ; Small-Conductance Calcium-Activated Potassium Channels ; Xenopus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 184
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    Chlamydia linked to atherosclerosis (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mlot, C -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1422.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633229" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Bacterial/blood ; Arteries/*microbiology ; Arteriosclerosis/*microbiology ; Carotid Arteries/microbiology ; Chlamydia Infections/*microbiology ; Chlamydophila pneumoniae/immunology/*isolation & purification ; Coronary Artery Disease/*microbiology ; Coronary Vessels/microbiology ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 185
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    After the genome (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crabbe, J -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1594-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8984618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Genes ; *Human Genome Project ; Humans ; Proteins/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 186
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    Hedgehog's patterning call is patched through, smoothly (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1304-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966601" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Body Patterning ; Carcinoma, Basal Cell/genetics/therapy ; Hedgehog Proteins ; Humans ; Membrane Proteins/genetics/*metabolism ; Mutation ; Proteins/*metabolism ; Receptors, Cell Surface/*metabolism/physiology ; *Receptors, G-Protein-Coupled ; Signal Transduction ; Skin Neoplasms/genetics/therapy ; *Trans-Activators
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 187
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    Scourge of Africa (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1996 Nov 8;274(5289):923.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966573" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*epidemiology ; Adolescent ; Africa South of the Sahara/epidemiology ; Child ; Developing Countries ; Female ; Humans ; Male
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 188
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    Bioethical issues (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korn, D -- New York, N.Y. -- Science. 1996 May 31;272(5266):1248-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650529" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bioethics ; Confidentiality ; *Genetics, Medical ; Humans ; Informed Consent ; *Research ; Tissue Banks
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 189
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    Live long and prosper? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1996 Jul 5;273(5271):42-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658190" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aged ; Aged, 80 and over ; Developed Countries ; Family ; *Health Status ; Humans ; *Life Expectancy ; *Longevity ; Retirement ; Social Security
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 190
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    Activation of Pyk2 by stress signals and coupling with JNK signaling pathway (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-09
    Beschreibung: The c-Jun amino-terminal kinase (JNK) is activated by various heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors, inflammatory cytokines, and stress signals. Yet, upstream mediators that link extracellular signals with the JNK signaling pathway are currently unknown. The tyrosine kinase Pyk2 was activated by tumor necrosis factor alpha, by ultraviolet irradiation, and by changes in osmolarity. Overexpression of Pyk2 led to activation of JNK, and a dominant-negative mutant of Pyk2 interfered with ultraviolet light- or osmotic shock-induced activation of JNK. Pyk2 represents a cell type-specific, stress-sensitive mediator of the JNK signaling pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tokiwa, G -- Dikic, I -- Lev, S -- Schlessinger, J -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):792-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670418" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anisomycin/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Egtazic Acid/pharmacology ; Enzyme Activation ; Focal Adhesion Kinase 2 ; GTP Phosphohydrolases/metabolism ; GTP-Binding Proteins/metabolism ; HL-60 Cells ; Humans ; JNK Mitogen-Activated Protein Kinases ; *Mitogen-Activated Protein Kinases ; Osmolar Concentration ; PC12 Cells ; Phosphorylation ; Protein-Tyrosine Kinases/*metabolism ; Rats ; *Signal Transduction ; Sorbitol/pharmacology ; Transfection ; Tumor Necrosis Factor-alpha/pharmacology ; Ultraviolet Rays
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 191
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    Biotech finds a growth industry (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1996 Jul 19;273(5273):300-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8685712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biotechnology ; Cell Differentiation/genetics ; *Developmental Biology ; Genetic Engineering ; Humans ; *Molecular Biology ; Nerve Regeneration/genetics ; Patents as Topic ; Proteins/genetics/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 192
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    Manic-depression findings spark polarized debate (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):31-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600531" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Bipolar Disorder/*genetics ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 15 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 4 ; Chromosomes, Human, Pair 6 ; Female ; Genetic Linkage ; Humans ; Lod Score ; Male ; Pedigree
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 193
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    Battling heart disease (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-07-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Labarthe, D R -- New York, N.Y. -- Science. 1996 Jul 5;273(5271):15-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658182" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anticholesteremic Agents/therapeutic use ; Coronary Disease/*epidemiology/etiology/prevention & control ; Humans ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 194
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    New virus variant killed Serengeti cats (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):596.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571120" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Distemper/transmission/*virology ; Distemper Virus, Canine/classification/*genetics ; Dogs ; *Genome, Viral ; Humans ; Lions/*virology ; Mutation ; Species Specificity ; Tanzania
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 195
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    Guarding against premature birth (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1996 Jan 12;271(5246):139-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539610" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Obstetric Labor, Premature/etiology/*prevention & control ; Placenta/microbiology ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy/epidemiology ; Ureaplasma Infections/complications/*drug therapy/epidemiology ; Ureaplasma urealyticum/isolation & purification ; Uterine Diseases/complications/*drug therapy/epidemiology ; Vaginosis, Bacterial/complications/*drug therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 196
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    Quantitative image analysis of HIV-1 infection in lymphoid tissue (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-08
    Beschreibung: Tracking human immunodeficiency virus-type 1 (HIV-1) infection at the cellular level in tissue reservoirs provides opportunities to better understand the pathogenesis of infection and to rationally design and monitor therapy. A quantitative technique was developed to determine viral burden in two important cellular compartments in lymphoid tissues. Image analysis and in situ hybridization were combined to show that in the presymptomatic stages of infection there is a large, relatively stable pool of virions on the surfaces of follicular dendritic cells and a smaller pool of productively infected cells. Despite evidence of constraints on HIV-1 replication in the infected cell population in lymphoid tissues, estimates of the numbers of these cells and the virus they could produce are consistent with the quantities of virus that have been detected in the bloodstream. The cellular sources of virus production and storage in lymphoid tissues can now be studied with this approach over the course of infection and treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haase, A T -- Henry, K -- Zupancic, M -- Sedgewick, G -- Faust, R A -- Melroe, H -- Cavert, W -- Gebhard, K -- Staskus, K -- Zhang, Z Q -- Dailey, P J -- Balfour, H H Jr -- Erice, A -- Perelson, A S -- AI 27661/AI/NIAID NIH HHS/ -- AI 28246/AI/NIAID NIH HHS/ -- RR 06555/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):985-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8875941" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Antisense Elements (Genetics) ; Autoradiography ; CD4 Lymphocyte Count ; Dendritic Cells/*virology ; HIV Infections/drug therapy/immunology/*virology ; HIV-1/*physiology ; Humans ; Image Processing, Computer-Assisted ; In Situ Hybridization ; Leukocytes, Mononuclear/*virology ; Lymph Nodes/virology ; Lymphoid Tissue/*virology ; Palatine Tonsil/virology ; RNA Probes ; RNA, Viral/analysis/blood ; Sensitivity and Specificity ; Spleen/virology ; *Viral Load
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 197
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    Guiding neurons to the cortex (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1996 Nov 15;274(5290):1100-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966585" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/abnormalities/embryology ; Brain Diseases/genetics ; Cell Adhesion Molecules, Neuronal/*genetics/physiology ; Cell Movement ; Cerebral Cortex/cytology/*embryology ; Cloning, Molecular ; Cyclin-Dependent Kinase 5 ; *Cyclin-Dependent Kinases ; Extracellular Matrix Proteins/*genetics/physiology ; Female ; Humans ; Intellectual Disability/genetics ; Male ; Mice ; Mice, Neurologic Mutants ; Nerve Tissue Proteins/genetics/physiology ; Neurons/*physiology ; Protein-Serine-Threonine Kinases/physiology ; Serine Endopeptidases
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 198
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    DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-01-19
    Beschreibung: About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4, a gene similar in sequence to a Drosophila melanogaster gene (Mad) implicated in a transforming growth factor-beta (TGF-beta)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hahn, S A -- Schutte, M -- Hoque, A T -- Moskaluk, C A -- da Costa, L T -- Rozenblum, E -- Weinstein, C L -- Fischer, A -- Yeo, C J -- Hruban, R H -- Kern, S E -- CA62924/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):350-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553070" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Amino Acid Sequence ; Animals ; Base Sequence ; Cell Division ; Chromosome Mapping ; *Chromosomes, Human, Pair 18 ; *DNA-Binding Proteins ; Gene Deletion ; Gene Expression ; *Genes, Tumor Suppressor ; Genetic Markers ; Humans ; Mice ; Molecular Sequence Data ; Mutation ; Neoplasm Transplantation ; Pancreatic Neoplasms/*genetics/pathology ; Proteins/chemistry/*genetics/physiology ; Signal Transduction ; Smad4 Protein ; *Trans-Activators ; Transforming Growth Factor beta/physiology ; Transplantation, Heterologous ; Tumor Cells, Cultured
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 199
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    Attomole protein characterization by capillary electrophoresis-mass spectrometry (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-08-30
    Beschreibung: Electrospray ionization with an ultralow flow rate (〈/=4 nanoliters per minute) was used to directly couple capillary electrophoresis with tandem mass spectrometry for the analysis and identification of biomolecules in mixtures. A Fourier transform mass spectrometer provided full spectra (〉30 kilodaltons) at a resolving power of approximately 60,000 for injections of 0.7 x 10(-18) to 3 x 10(-18) mole of 8- to 29-kilodalton proteins with errors of 〈1 dalton in molecular mass. Using a crude isolate from human blood, a value of 28,780.6 daltons (calculated, 28,780.4 daltons) was measured for carbonic anhydrase, representing 1 percent by weight of the protein in a single red blood cell. Dissociation of molecular ions from 9 x 10(-18) mole of carbonic anhydrase gave nine sequence-specific fragment ions, more data than required for unique retrieval of this enzyme from the protein database.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valaskovic, G A -- Kelleher, N L -- McLafferty, F W -- 08-T2GM07273/GM/NIGMS NIH HHS/ -- GM16609/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 30;273(5279):1199-202.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8703047" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbonic Anhydrases/*analysis/chemistry ; Cattle ; Cytochrome c Group/analysis/chemistry ; Electrophoresis, Capillary/*methods ; Horses ; Humans ; Mass Spectrometry/*methods ; Molecular Weight ; Proteins/*analysis/chemistry ; Sensitivity and Specificity ; Spectroscopy, Fourier Transform Infrared ; Ubiquitins/analysis/chemistry
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 200
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    Genetics and race (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rushton, J P -- New York, N.Y. -- Science. 1996 Feb 2;271(5249):579-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8571114" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Continental Population Groups/*genetics ; *Genetics, Medical ; Humans ; Intelligence/*genetics ; Socioeconomic Factors ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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