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  • Articles  (704)
  • Rats  (704)
  • 1980-1984  (704)
  • Biology  (704)
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  • Articles  (704)
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  • 101
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    Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: (+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their behavioral effects on squirrel monkeys and rats trained to discriminate phencyclidine from saline. Dose-response determinations were made for responses to phencyclidine, to a racemic mixture of N-allylnormetazocine, and to the pure levo and dextro isomers of N-allylnormetazocine. In both rats and monkeys, the dextro isomer and the racemic mixture produced dose-dependent responses appropriate for phencyclidine; the levo isomer did not produce the responses appropriate for phencyclidine at any of the doses tested. In both species, the levo isomer was more potent than the dextro isomer in decreasing the rate of responding. Thus racemic N-allylnormetazocine is a mixture of compounds that produce different behavioral effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brady, K T -- Balster, R L -- May, E L -- DA-00490/DA/NIDA NIH HHS/ -- DA-01442/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274022" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Male ; Naloxone/pharmacology ; Phenazocine/*analogs & derivatives/pharmacology ; Phencyclidine/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid/drug effects ; Saimiri ; Stereoisomerism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. These findings suggest that the normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridges, R S -- Grimm, C T -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Drug Antagonism ; Female ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Long-term synaptic potentiation in the superior cervical ganglion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, T H -- McAfee, D A -- 12116/PHS HHS/ -- NS 16576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Sympathetic/*physiology ; Kinetics ; Learning/*physiology ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: The electrophysiological effects of ethanol in low doses (5 to 20 millimoles per liter or 23 to 92 milligrams per 100 milliliters) were examined intracellularly in CA1 cells of rat hippocampus in vitro. Inhibitory and excitatory postsynaptic potentials were increased when ethanol was applied to the respective synaptic terminal regions. Postsynaptically, ethanol caused a moderate hyperpolarization with increased membrane conductance, even when synaptic transmission was blocked. Ethanol augmented the hyperpolarization that followed repetitive firing or that followed the eliciting of calcium spikes in the presence of tetrodotoxin, but not the rapid afterhyperpolarization in calcium-free medium. Ethanol appears to augment calcium-mediated mechanisms both pre- and postsynaptically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Gurevich, N -- Durand, D -- R01 NS16660-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Electric Conductivity ; Ethanol/*pharmacology ; Hippocampus/*drug effects/physiology ; Male ; Membrane Potentials/drug effects ; Potassium/physiology ; Rats ; Rats, Inbred Strains ; Synaptic Membranes/drug effects ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    High angiotensin-converting enzyme activity in the neurohypophysis of Brattleboro rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats. The high activity level was reversed by vasopressin treatment. Conversely, angiotensin-converting enzyme activity was significantly lower in the anterior pituitary of Brattleboro rats than in Long-Evans rats, and this activity level was not affected by vasopressin. these findings suggest an inverse relation between vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chevillard, C -- Saavedra, J M -- New York, N.Y. -- Science. 1982 May 7;216(4546):646-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Insipidus/*enzymology/genetics ; Disease Models, Animal ; Peptidyl-Dipeptidase A/*metabolism ; Pituitary Gland, Posterior/*enzymology ; Rats ; Rats, Mutant Strains/*physiology ; Vasopressins/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: Localization of the anatomic substrate for anticonvulsant activity mediated by gamma-aminobutyric acid (GABA) was examined using intracerebral injections of GABA agonists. Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum. Elevation of GABA in forebrain and hindbrain areas had no effect on convulsant activity. Blockade of tonic and clonic seizures was also obtained after microinjections of the direct GABA receptor agonist, muscimol, into the midbrain. The substantia nigra was identified as the critical midbrain site for GABA-mediated anticonvulsant activity. Local injection of GABA agonists into the midbrain provided seizure protection without a widespread augmentation of GABA-mediated activity throughout the brain and without impairing either alertness or motor function. Synapses in the substantia nigra appear to represent an important control mechanism for inhibiting the propagation of generalized convulsions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iadarola, M J -- Gale, K -- DA 02206/DA/NIDA NIH HHS/ -- MH32359/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1237-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146907" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Brain Mapping ; GABA Antagonists ; Male ; Muscimol/pharmacology ; Pentylenetetrazole/pharmacology ; Rats ; Seizures/*physiopathology ; Substantia Nigra/*physiology ; gamma-Aminobutyric Acid/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Growth hormone stimulates longitudinal bone growth directly (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Local administration of human growth hormone in vivo to the cartilage growth plate of the proximal tibia of hypophysectomized rats resulted in accelerated longitudinal bone growth. This finding suggests that growth hormone directly stimulates the cells in the growth plate, and does not support the theory that the increase in the plasma concentration of somatomedin that follows growth hormone administration is the cause of this stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isaksson, O G -- Jansson, J O -- Gause, I A -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079756" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Development/*drug effects ; Bone and Bones/*drug effects ; Growth Hormone/*pharmacology ; Male ; Prolactin/pharmacology ; Rats ; Somatomedins/pharmacology ; Stimulation, Chemical
    Print ISSN: 0036-8075
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  • 109
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    Naloxone antagonism of the thermoregulatory effects of phencyclidine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glick, S D -- Guido, R A -- DA 02534/DA/NIDA NIH HHS/ -- DA 70082/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation/*drug effects ; Dose-Response Relationship, Drug ; Female ; Naloxone/pharmacology ; Phencyclidine/antagonists & inhibitors/*pharmacology ; Rats ; Receptors, Opioid/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Serial position curve in rats: role of the dorsal hippocampus (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: In an eight-arm radial maze, normal rats demonstrated good immediate retention for the order of first items (primacy component of serial position curve) and last items (recency component of serial position curve) of an eight-item (arm) list. In contrast, rats with dorsal hippocampal lesions displayed, on an immediate retention test, disruption of the primacy but not the recency component of the serial position curve. Furthermore, imposing a 10-minute delay before the retention test impaired all components of the serial position curve. These results support correspondence in mnemonic function of the hippocampus in animals and humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kesner, R P -- Novak, J M -- RR07092-12/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hippocampus/anatomy & histology/*physiology ; Male ; Memory/drug effects ; Rats ; *Serial Learning
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    Monoclonal antibody to acetylcholine receptor: cell line established from thymus of patient with Myasthenia gravis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: A human B cell line producing a monoclonal antibody to an antigenic determinant of acetylcholine receptors was established by cloning B cells that had been transformed in vitro by Epstein-Barr virus. The B cells were obtained from the thymus of a patient with myasthenia gravis. The antibody produced by the cell line precipitated acetylcholine receptors from denervated and innervated rat muscle and from human muscle, but did not show detectable response to the acetylcholine receptors from the electric organs of Narke japonica. The monoclonal antibody showed identical binding patterns in innervated and denervated rat muscles. Passive transfer of the monoclonal antibody into rats induced moderate muscle weakness and electromyographic changes characteristic of myasthenia gravis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamo, I -- Furukawa, S -- Tada, A -- Mano, Y -- Iwasaki, Y -- Furuse, T -- Ito, N -- Hayashi, K -- Satoyoshi, E -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):995-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Monoclonal ; B-Lymphocytes/immunology ; *Cell Line ; Cell Transformation, Viral ; Herpesvirus 4, Human ; Humans ; Muscles/immunology/innervation ; Myasthenia Gravis/immunology ; Rats ; Receptors, Cholinergic/*immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, R D -- Proudfit, H K -- Yeung, S M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):58-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123218" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/administration & dosage/*analogs & derivatives/pharmacology ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Apomorphine/pharmacology ; Caudate Nucleus/*physiology ; Corpus Striatum/*physiology ; Dopamine/*physiology ; Injections ; Kinetics ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Rotation ; Vasodilator Agents/*pharmacology
    Print ISSN: 0036-8075
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  • 113
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    Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, N W -- Plenefisch, J D -- Carey, S W -- Fredrickson, W T -- Sackett, G P -- Burbacher, T M -- Parker, R M -- HD02774/HD/NICHD NIH HHS/ -- HD08633/HD/NICHD NIH HHS/ -- RR00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053560" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/*blood ; Animals ; Congenital Abnormalities/*etiology ; Ectogenesis ; Female ; Macaca nemestrina/blood ; Mice ; Pregnancy ; Rats
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  • 114
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    Purinergic regulation of food intake (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, A S -- Morley, J E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Deoxyguanosine/pharmacology ; Diazepam/pharmacology ; Eating/*drug effects ; Food Deprivation ; Inosine/analogs & derivatives/pharmacology ; Insulin/pharmacology ; Male ; Muscimol/pharmacology ; Purines/*pharmacology ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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  • 115
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    Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Cyclic adenosine monophosphate (AMP) analogs or agents that increase intracellular cyclic AMP rapidly stimulate transcription of the prolactin gene in a line of cultured rat pituitary cells. This effect is correlated with the phosphorylation of a chromatin-associated basic protein designated BPR. These data are consistent with the postulate that increased intracellular cyclic AMP concentrations induce rapid transcriptional effects on specific genes in eukaryotes, mediated by direct or indirect phosphorylation of a specific chromatin-associated protein or proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murdoch, G H -- Rosenfeld, M G -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293056" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromatin/*metabolism ; Cyclic AMP/analogs & derivatives/*metabolism ; Nucleoproteins/metabolism ; Phosphorylation ; Pituitary Gland/metabolism ; Prolactin/genetics ; Rats ; *Transcription, Genetic
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  • 116
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    Suprachiasmatic stimulation phase shifts rodent circadian rhythms (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: The integrity of the suprachiasmatic nuclei (SCN) of the hypothalamus is essential to the expression of normal circadian rhythms in rodents. Electrical stimulation of the SCN caused phase shifts and period changes in the freerunning feeding rhythms of rats and activity rhythms of hamsters. The phase response curve for SCN stimulation appears to parallel that for light pulses. These findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rusak, B -- Groos, G -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063851" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; *Circadian Rhythm ; Electric Stimulation ; Hypothalamus/*physiology ; Neurons/physiology ; Rats
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    Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nekola, M B -- Horvath, A -- Ge, L J -- Coy, D H -- Schally, A V -- HD-0-2831/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):160-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750790" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Female ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/secretion ; Ovulation/*drug effects ; Pregnancy ; Proestrus/drug effects ; Rats ; Rats, Inbred Strains
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    Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-09
    Description: A riboflavin carrier protein isolated from chickens cross-reacts with a gestation-specific rodent carrier for riboflavin. Active immunization of female rats of proved fertility with the purified chicken carrier protein completely yet reversibly suppressed early pregnancy without impairing implantation per se. Concurrently there were no discernible adverse effects on maternal health in terms of weight gain, vitamin status, and fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murty, C V -- Adiga, P R -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Carrier Proteins/*immunology ; Female ; Fetal Resorption/immunology ; Flavins/blood ; Glutathione Reductase/blood ; Immunization ; *Membrane Transport Proteins ; Pregnancy ; *Pregnancy, Animal ; Progesterone/blood ; Rats
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    General anesthetics hyperpolarize neurons in the vertebrate central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-10
    Description: The effect of general anesthetics on frog motoneurons and rat hippocampus pyramidal cells was examined with sucrose gap and intracellular recording, respectively. A number of volatile and intravenous anesthetics directly hyperpolarized the motoneurons. The potency of these agents in hyperpolarizing motoneurons was strongly correlated with their anesthetic potency. While the responses to barbiturates and alpha-chloralose were blocked by gamma-aminobutyric acid antagonists and were dependent on the chloride gradient, the responses to all the other anesthetics tested were generated by a separate mechanism. Intracellular recording from hippocampal pyramidal cells suggested that an increase in potassium conductance accounts for these responses. Such a nonsynaptic action would contribute to the decreased neuronal responsiveness observed for these compounds and thus to their anesthetic action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicoll, R A -- Madison, D V -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112112" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthetics/*pharmacology ; Animals ; Ether/pharmacology ; Halothane/pharmacology ; Hippocampus/*drug effects ; Microelectrodes ; Motor Neurons/drug effects ; Potassium/metabolism ; Rats
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    A diurnal rhythm in pineal protein 1 content mediated by beta-adrenergic neurotransmission (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestler, E J -- Zata, M -- Greengard, P -- MH-17387/MH/NIMH NIH HHS/ -- NS-08440/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):357-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124039" target="_blank"〉PubMed〈/a〉
    Keywords: 8-Bromo Cyclic Adenosine Monophosphate ; Adrenergic beta-Agonists/*pharmacology ; Animals ; *Circadian Rhythm ; Cyclic AMP/analogs & derivatives/pharmacology ; Cyclic GMP/analogs & derivatives/pharmacology ; Isoproterenol/pharmacology ; Nerve Tissue Proteins/*physiology ; Norepinephrine/pharmacology ; Organ Culture Techniques ; Pineal Gland/drug effects/physiology ; Propranolol/pharmacology ; Rats ; Synapsins
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    Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-01
    Description: Administration of the hepatic carcinogen aflatoxin B1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B1 on the mitochondrial genetic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niranjan, B G -- Bhat, N K -- Avadhani, N G -- CA-22762/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797067" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxin B1 ; Aflatoxins/*metabolism ; Animals ; DNA, Mitochondrial/*metabolism ; Kinetics ; Liver Neoplasms/*chemically induced/metabolism ; Male ; Mitochondria, Liver/*metabolism ; Neoplasms, Experimental/chemically induced ; Protein Biosynthesis/drug effects ; Rats ; Transcription, Genetic/drug effects
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    Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto-Sampedro, M -- Lewis, E R -- Cotman, C W -- Manthorpe, M -- Skaper, S D -- Barbin, G -- Longo, F M -- Varon, S -- AG-00538/AG/NIA NIH HHS/ -- MH-19691/MH/NIMH NIH HHS/ -- NS-16349/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):860-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100931" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/physiology ; Animals ; Brain/*physiology ; Brain Injuries/*physiopathology ; Cell Survival/drug effects ; Cells, Cultured ; Cholinergic Fibers/physiology ; Kinetics ; Nerve Growth Factors/*metabolism/pharmacology ; *Nerve Regeneration ; Rats ; Rats, Inbred Strains ; Wound Healing
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    Hemispheric asymmetries in the behavioral and hormonal effects of sexually differentiating mammalian brain (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-22
    Description: Estrogen pellets were placed in either the right or left hypothalamus of newborn female rats so that only one side of this brain area was exposed to the postnatal masculinizing and defeminizing effects of the hormone. The effects of estrogen on gonadotropin secretion and reproductive behavior depended on both the region and the side of implantation. Exposure of the left hypothalamus to estrogen resulted in defeminized development. Exposure of the right hypothalamus to estrogen resulted in masculinized development. Thus the response of the developing hypothalamus to gonadal steroids may be asymmetric.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nordeen, E J -- Yahr, P -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123240" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*pharmacology ; Female ; *Functional Laterality ; Hypothalamus/*physiology ; Male ; Ovary/growth & development ; Rats ; *Sex Differentiation/drug effects ; Sexual Behavior, Animal/physiology
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    Oxytocin induces maternal behavior in virgin female rats (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-07
    Description: Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, C A -- Ascher, J A -- Monroe, Y L -- Prange, A J Jr -- MH-22536/MH/NIMH NIH HHS/ -- MH-32316/MH/NIMH NIH HHS/ -- MH-34933/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):648-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine Vasopressin/pharmacology ; Brain/physiology ; Female ; Injections, Intraventricular ; *Maternal Behavior ; Oxytocin/administration & dosage/*pharmacology ; Rats ; Structure-Activity Relationship
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    Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-21
    Description: Rat embryo fibroblasts transformed by Abelson murine leukemia virus (MuLV) produce and release a transforming growth factor (TGF). Production of this factor is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Transformation-defective mutants of Abelson MuLV do not transform cells, do not have their virus coded transforming gene product phosphorylated in tyrosine, and do not induce TGF production. Abelson MuLV-induced TGF morphologically transforms cells in culture, competes with 125I-labeled epidermal growth factor (EGF) for binding to cell receptors, and induces phosphorylation of tyrosine acceptor sites in the 160,000-dalton EGF membrane receptor. After purification to homogeneity, Abelson virus-induced TGF migrates as a single polypeptide with an apparent size of 7400 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Twardzik, D R -- Todaro, G J -- Marquardt, H -- Reynolds, F H Jr -- Stephenson, J R -- New York, N.Y. -- Science. 1982 May 21;216(4548):894-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177040" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus ; Animals ; *Cell Transformation, Neoplastic ; *Cell Transformation, Viral ; Molecular Weight ; Peptides/*metabolism ; Phosphotyrosine ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; Transforming Growth Factors ; Tyrosine/analogs & derivatives/metabolism
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    Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-22
    Description: Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, C -- Rivier, J -- Vale, W -- AM18811/AM/NIADDK NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):377-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289439" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Adrenocorticotropic Hormone/blood/*secretion ; Animals ; Antibodies ; Antigen-Antibody Complex ; Corticotropin-Releasing Hormone/*immunology ; Male ; Rats ; Secretory Rate/drug effects
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    Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-17
    Description: 2'-Fluoro-5-methyl-l-beta-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography. FMAU is a potent antiviral pyrimidine nucleoside which is selectively phosphorylated by virus-coded thymidine kinase. When the labeled FMAU was administered 6 hours before the rats were killed, the selective uptake and concentration of the drug and its metabolites by infected cells (defined by immunoperoxidase staining of viral antigens) allowed quantitative definition and mapping of HSV-1-infected structures in autoradiograms of brain sections. These results show that quantitative autoradiography can be used to characterize the local metabolism of antiviral drugs by infected cells in vivo. They also suggest that the selective uptake of drugs that exploit viral thymidine kinase for their antiviral effect can, by appropriate labeling, be used in conjunction with clinical neuroimaging techniques to define infected regions of human brain, thereby providing a new approach to the diagnosis of herpes encephalitis in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saito, Y -- Price, R W -- Rottenberg, D A -- Fox, J J -- Su, T L -- Watanabe, K A -- Philips, F S -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112121" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antiviral Agents ; Arabinofuranosyluracil/*analogs & derivatives ; Autoradiography ; Cytarabine/analogs & derivatives ; Encephalitis/microbiology/*pathology ; Herpes Simplex/*pathology ; Rats ; Uridine/*analogs & derivatives
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    Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-22
    Description: Gonadotropic activation of the adult rat testis in vitro and in vivo is followed by down-regulation of luteinizing hormone receptors and decreased androgen responses to subsequent hormonal stimulation. In contrast, treatment of cultured fetal testes with gonadotropins and dibutyryl adenosine 3',5'-monophosphate enhanced steroidogenic responsiveness and did not cause the luteinizing hormone-receptor loss and desensitization that is characteristic of the adult gonad. The analysis of gonadotropin receptors and action in cultured fetal testis cells facilitates developmental studies of gonadal function, and has revealed significant differences in the responses of fetal and adult Leydig cells to gonadotropic regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warren, D W -- Dufau, M L -- Catt, K J -- 1F33-HD06192/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):375-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289438" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bucladesine/pharmacology ; Cell Differentiation/drug effects ; Cells, Cultured ; Chorionic Gonadotropin/pharmacology ; Hydroxyprogesterones/biosynthesis ; Leydig Cells/*drug effects ; Luteinizing Hormone/pharmacology ; Male ; Progesterone/biosynthesis ; Rats ; Receptors, Cell Surface/*drug effects/metabolism ; Receptors, LH ; Testis/*embryology/metabolism ; Testosterone/biosynthesis
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    Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-09
    Description: Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrew, R D -- Dudek, F E -- NS 16877/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879204" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Electrophysiology ; Evoked Potentials ; Feedback ; Hypothalamus/cytology ; In Vitro Techniques ; Membrane Potentials ; Neurosecretory Systems/cytology/*physiology ; Rats ; Tetrodotoxin/pharmacology
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    Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bengtsson, M -- Rydstrom, J -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Epoxide Hydrolases/metabolism ; *Estrus ; Female ; Glutathione Transferase/metabolism ; Gonadotropins, Equine/*pharmacology ; Metestrus ; Ovary/*physiology ; Pregnancy ; Proestrus ; Quinone Reductases/metabolism ; Rats ; Rats, Inbred Strains
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    Aspartate: possible neurotransmitter in cerebellar climbing fibers (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-02
    Description: Autoradiography demonstrated prominent retrograde labeling of olivocerebellar climbing fiber neurons after injection of tritiated D-aspartate into the rat cerebellar cortex or deep nuclei. Mossy fiber systems originating in the brainstem and spinal cord remained unlabeled. Potassium ion-induced depolarization of cerebellar slices resulted in calcium ion-dependent release of endogenous L-aspartate, L-glutamate, gamma-aminobutyric acid, and glycine. A 26 percent decrease in aspartate release was observed after 3-acetylpyridine-induced destruction of the inferior olive, supporting the hypothesis that aspartate is a neurotransmitter in climbing fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiklund, L -- Toggenburger, G -- Cuenod, M -- New York, N.Y. -- Science. 1982 Apr 2;216(4541):78-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6121375" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Aspartic Acid/*metabolism ; Cerebellum/cytology/*metabolism ; Glutamates/metabolism ; Glutamic Acid ; Glycine/metabolism ; Neural Pathways/metabolism ; Neurotransmitter Agents/*metabolism ; Rats ; gamma-Aminobutyric Acid/metabolism
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    Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wysor, M S -- Zwelling, L A -- Sanders, J E -- Grenan, M M -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):454-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7201165" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cisplatin/adverse effects ; Disulfiram/*administration & dosage ; Kidney/pathology ; Male ; Mice ; Mice, Inbred ICR ; Necrosis/chemically induced ; Rats ; Sodium Chloride/administration & dosage ; Trypanosoma/drug effects ; Trypanosomiasis, African/pathology/*therapy
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    Time course of alpha-flupenthixol action explains "response artifacts" of neuroleptic action on brain stimulation reward (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 16;222(4629):1251-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Flupenthixol/*pharmacology ; Hypothalamus/*drug effects ; Kinetics ; Rats ; *Reward ; Self Stimulation/*drug effects ; Thioxanthenes/*pharmacology
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    Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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    Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinckerhoff, C E -- Coffey, J W -- Sullivan, A C -- AM14780/AM/NIADDK NIH HHS/ -- P60 AM20641/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):756-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis/*drug therapy ; Arthritis, Experimental/*drug therapy ; Female ; Fibrinogen/blood ; Inflammation/drug therapy ; Male ; Microbial Collagenase/biosynthesis ; Prostaglandins E/biosynthesis ; Rats ; Sex Factors ; Tretinoin/*therapeutic use
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    Ventral posterior thalamic neurons differentially responsive to noxious stimulation of the awake monkey (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-12
    Description: Of 76 cutaneously activated neurons recorded from the ventral posterior thalamus of awake, behaving monkeys, nine were weakly excited by innocuous skin stimulation and responded maximally only when noxious mechanical cutaneous stimuli were delivered within small, contralateral receptive fields. These results show that neurons capable of encoding the spatial and temporal features of noxious stimuli are located in the ventral posterior thalamus of the awake primate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casey, K L -- Morrow, T J -- NS 12581/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):675-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Consciousness/physiology ; Electric Stimulation ; Neurons, Afferent/physiology ; Pain/*physiopathology ; Physical Stimulation ; Rats ; Saimiri ; Thalamic Nuclei/physiology ; Thalamus/cytology/*physiology
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    Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Extracellular single-unit recording techniques were used to test the ability of proglumide to block cholecystokinin-induced excitation of rat midbrain dopaminergic neurons and dopamine-sensitive prefrontal cortex cells. Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity. This selective blockade of central cholecystokinin effects by proglumide suggests that this drug may be valuable for studying the possible role of cholecystokinin as a neurotransmitter or neuromodulator in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiodo, L A -- Bunney, B S -- MH-25642/MH/NIMH NIH HHS/ -- MH-28849/MH/NIMH NIH HHS/ -- NS-07136/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Cerebral Cortex/physiology ; Cholecystokinin/*pharmacology ; Drug Antagonism ; Glutamine/*analogs & derivatives ; Male ; Mesencephalon/physiology ; Neurons/drug effects/*physiology ; Proglumide/*pharmacology ; Rats
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    Gene splicers contemplate the rat brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):828-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6138857" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; DNA, Recombinant ; Gene Expression Regulation ; Nerve Tissue Proteins/*genetics ; Neurotransmitter Agents/*physiology ; Rats
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  • 139
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    Brief deprivation of vision after unilateral lesions of the frontal eye field prevents contralateral inattention (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-29
    Description: Brief deprivation of vision after unilateral lesions of the frontal eye field prevents the appearance of contralateral inattention to visual, auditory, and somatosensory stimuli. The forced circling that accompanies inattention, however, is not affected. An equivalent preoperative period in the dark only partly reduces inattention symptoms. Visual deprivation does not reduce or prevent inattention resulting from lesions of the superior colliculus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowne, D P -- Richardson, C M -- Ward, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):527-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836298" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention/*physiology ; Darkness ; Frontal Lobe/*physiology ; Male ; Movement ; Rats ; Sensory Deprivation/*physiology ; Superior Colliculi/*physiology ; Visual Perception/*physiology
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    Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
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    A polypeptide secreted by transformed cells that modulates human plasminogen activator production (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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    Human cancer research (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermer, G B -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Neoplasms ; Neoplasms, Experimental ; Rats ; Research
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    Collagen formation by the hepatocyte in primary monolayer culture and in vivo (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-18
    Description: Immunohistochemical techniques were used to confirm biochemical evidence that parenchymal cells isolated from adult rat liver and maintained in nonreplicating monolayer culture for 2 days synthesized type IV basement membrane collagen. On continued incubation in serum-free medium, the hepatocytes also synthesized the interstitial collagens, types I and III. Consistent with these results in culture, type IV collagen was localized to the hepatocytes in slices of pathologic rat liver. Hence collagen formation is a previously unrecognized function of the hepatocyte that may be important in the pathogenesis of liver fibrosis or cirrhosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diegelmann, R F -- Guzelian, P S -- Gay, R -- Gay, S -- AM18976/AM/NIADDK NIH HHS/ -- DE02570/DE/NIDCR NIH HHS/ -- HL11310/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1343-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/metabolism ; Cells, Cultured ; Collagen/*biosynthesis/immunology ; Liver/cytology/*metabolism ; Molecular Weight ; Rats
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    Direct in vivo monitoring of dopamine released from two striatal compartments in the rat (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of alpha-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after alpha-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewing, A G -- Bigelow, J C -- Wightman, R M -- KO 4 NS000356/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857277" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamine/pharmacology ; Animals ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Male ; Methyltyrosines/pharmacology ; Microelectrodes ; Naphthyridines/pharmacology ; Rats ; Rats, Inbred Strains ; alpha-Methyltyrosine
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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  • 146
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    Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-18
    Description: Cerebral glucose metabolism in rats was examined 1 week after the production by ibotenic acid of unilateral striatal lesions. The incorporation of carbon-14-labeled deoxyglucose decreased within the lesion but much less than that of carbon-14-labeled glucose. Barbiturate anesthesia caused a reversal of the asymmetric striatal deoxyglucose labeling, such that the lesioned striatum retained more tracer than the contralateral side. The combined use of barbiturates and radiolabeled deoxyglucose may enhance the identification of recent brain infarction in experimental animals and in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, K A -- Agranoff, B W -- 1 T32 GM07863/GM/NIGMS NIH HHS/ -- NS 15655/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):879-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Barbiturates/*pharmacology ; Brain/*drug effects/metabolism ; Brain Diseases/chemically induced/metabolism ; Corpus Striatum/drug effects ; Deoxyglucose ; Glucose/metabolism ; Ibotenic Acid ; Rats
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  • 147
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    Light and propranolol suppress the nocturnal elevation of serotonin in the cerebrospinal fluid of rhesus monkeys (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-29
    Description: Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinal fluid were reduced to daytime levels by exposing the monkeys to continuous light or to the beta-adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garrick, N A -- Tamarkin, L -- Taylor, P L -- Markey, S P -- Murphy, D L -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):474-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm/drug effects ; Humans ; *Light ; Macaca mulatta ; Male ; Melatonin/physiology ; Propranolol/*pharmacology ; Rats ; Serotonin/*cerebrospinal fluid/physiology
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    Mutagenicity of glutathione and cysteine in the Ames test (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-27
    Description: Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term test for carcinogenicity and mutagenicity. Glutathione is positive in the test even at concentrations found in mammalian tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glatt, H -- Protic-SabljiC, M -- Oesch, F -- New York, N.Y. -- Science. 1983 May 27;220(4600):961-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cysteine/*pharmacology ; Glutathione/*pharmacology ; Histidine/metabolism ; Hydrogen Peroxide/metabolism ; Kidney/metabolism ; Liver/metabolism ; *Mutagenicity Tests ; Mutagens/*pharmacology ; Rats ; Salmonella typhimurium/metabolism
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    Cortical dopaminergic involvement in cocaine reinforcement (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: Neuronal systems involved in the initiation of cocaine reinforcement were investigated by identifying brain sites where direct application of the drug was reinforcing. This was accomplished by allowing rats to self-administer picomolar concentrations of cocaine into discrete brain regions. The medial prefrontal cortex supported self-administration, while the nucleus accumbens and ventral tegmental area did not. Self-administration could be attenuated by including equimolar concentrations of the dopaminergic D2-receptor antagonist sulpiride in the microinjection system. These results imply that cocaine reinforcement is mediated in part through a direct action on mesocortical dopaminergic receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goeders, N E -- Smith, J E -- DA-01999-04/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cerebral Cortex/*drug effects/physiology ; Cocaine/*pharmacology ; Dopamine/*physiology ; Male ; Nucleus Accumbens/physiology ; Rats ; Self Administration ; Sulpiride/pharmacology
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    Cocaine-induced rotation: sex-dependent differences between left- and right-sided rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Cocaine elicited dose-related rotation (circling) in naive rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glick, S D -- Hinds, P A -- Shapiro, R M -- DA 01044/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/*pharmacology ; Dextroamphetamine/pharmacology ; Female ; Functional Laterality ; Male ; Movement/*drug effects ; Rats ; Rotation ; Sex Factors
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  • 151
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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    Expression of a cellular oncogene during liver regeneration (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-04
    Description: The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyette, M -- Petropoulos, C J -- Shank, P R -- Fausto, N -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):510-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Tetrachloride Poisoning ; DNA/biosynthesis ; Hepatectomy ; *Liver Regeneration ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/biosynthesis ; Rats ; Sarcoma Viruses, Murine/genetics ; Time Factors ; *Transcription, Genetic
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  • 153
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    An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: In vitro binding studies have demonstrated the existence of multiple opiate receptor types. An additional site in the rat brain (termed the lambda site) is distinct from the established types by its selectivity for 4,5-epoxymorphinans (such as naloxone and morphine). While the lambda site displays a high affinity for naloxone in vivo and in vitro in fresh brain membrane homogenates, these sites rapidly convert in vitro to a state of low affinity. The regional distribution of the lambda site in the brain is strikingly different from that of the classic opiate receptor types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grevel, J -- Sadee, W -- AG 031047/AG/NIA NIH HHS/ -- DA 01095/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310750" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Dihydromorphine/metabolism ; Diprenorphine/metabolism ; Morphine/metabolism ; Nalorphine/metabolism ; Naloxone/*metabolism ; Naltrexone/metabolism ; Rats ; Receptors, Opioid/*metabolism ; Sodium/metabolism ; Tissue Distribution
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  • 154
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    Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harlan, R E -- Shivers, B D -- Pfaff, D W -- HD-05585/HD/NICHD NIH HHS/ -- HD-05737/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828874" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Castration ; Cerebral Cortex/drug effects/*physiology ; Cosyntropin/pharmacology ; Estradiol/pharmacology ; Female ; Growth Hormone/pharmacology ; Immune Sera ; Kinetics ; Mesencephalon/*physiology ; Oxytocin/pharmacology ; Posture ; Prolactin/administration & dosage/*pharmacology ; Rats ; Sexual Behavior, Animal/*drug effects ; Vasopressins/pharmacology
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  • 155
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    Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haspel, M V -- Onodera, T -- Prabhakar, B S -- Horita, M -- Suzuki, H -- Notkins, A L -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301002" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology/*microbiology ; Endocrine Glands/*immunology ; Enzyme-Linked Immunosorbent Assay ; Growth Hormone/immunology ; Humans ; Hybridomas/immunology ; Mice ; Pituitary Gland, Anterior/immunology ; Rats ; Reoviridae Infections/*immunology
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  • 156
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    Contiguity to males in utero affects avoidance responding in adult female mice (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-22
    Description: Female mice that had been situated in utero between two female fetuses displayed higher levels of active avoidance responding in adult life than females that had been located between two male fetuses and males for whom uterine position was without effect. Uterine position, therefore, influences acquired as well as species-typical behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hauser, H -- Gandelman, R -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836288" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/physiology ; Animals ; Avoidance Learning/*physiology ; Female ; Fetus/*physiology ; Male ; Mice ; Pregnancy ; Rats ; Sex Factors ; Uterus
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    In vivo one-dimensional imaging of phosphorus metabolites by phosphorus-31 nuclear magnetic resonance (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: A phosphorus-31 nuclear magnetic resonance imaging technique has been used to obtain information on phosphorus metabolites from different spatial regions of tissues in vivo. The technique for selection of planes through the tissue is based on phase-encoding of spin echoes and was used to obtain one-dimensional discrimination of phosphorus-31 spectra from different parts of the tissue simultaneously. Specimens were resolved into 16 distinct slices and a signal-to-noise ratio of about 20 to 1 was obtained in 1/2 hour. Results are presented for phantoms, rat legs, and gerbil heads.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haselgrove, J C -- Subramanian, V H -- Leigh, J S Jr -- Gyulai, L -- Chance, B -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1170-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857240" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Gerbillinae ; Magnetic Resonance Spectroscopy/*methods ; Phosphocreatine/metabolism ; Phosphoric Acids/metabolism ; Phosphorus/*metabolism ; Rats
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    Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-29
    Description: Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedlund, B -- Abens, J -- Bartfai, T -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/*pharmacology ; Gastrointestinal Hormones/*metabolism ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*drug effects ; Receptors, Muscarinic/analysis/*drug effects ; Salivary Glands/analysis/innervation ; Vasoactive Intestinal Peptide/analysis/*metabolism
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  • 159
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    Lines of T lymphocytes induce or vaccinate against autoimmune arthritis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-07
    Description: The pathophysiology of autoimmune arthritis was studied by selecting and isolating lines of effector T lymphocytes from rats administered an arthritogenic dose of Mycobacterium tuberculosis in complete Freund's adjuvant to induce adjuvant arthritis. Irradiated rats were intravenously inoculated with a cell line characterized by proliferative reactivity to Mycobacterium tuberculosis and, to a lesser degree, to rat collagen type II. This produced arthritis in all the irradiated rats. Nonirradiated recipients failed to develop arthritis. However, such rats, and those recovering from cell-mediated arthritis, were resistant to subsequent attempts to induce adjuvant arthritis. Lines of T lymphocytes selected for responsiveness to other antigens had no effect. Therefore, a line of T lymphocytes responsive to bacteria or to collagen type II could either induce autoimmune arthritis or serve as an agent of vaccination against it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holoshitz, J -- Naparstek, Y -- Ben-Nun, A -- Cohen, I R -- NS 18168/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):56-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6336851" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis/*etiology ; Arthritis, Experimental/etiology ; Autoimmune Diseases/*etiology ; Collagen/immunology ; Lymphocyte Activation ; Rats ; T-Lymphocytes/*immunology ; Vaccination ; Whole-Body Irradiation
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    Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honchar, M P -- Olney, J W -- Sherman, W R -- MH-14677/MH/NIMH NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- NS-05159/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/pharmacology ; Brain Chemistry/drug effects ; Chlorides/adverse effects ; Drug Interactions ; Humans ; Inositol/analogs & derivatives/analysis ; *Inositol Phosphates ; Lithium/*adverse effects ; Lithium Chloride ; Male ; Parasympathomimetics/*adverse effects ; Physostigmine/adverse effects ; Pilocarpine/adverse effects ; Rats ; Rats, Inbred Strains ; Seizures/*chemically induced ; Substance-Related Disorders/*etiology
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  • 161
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    A parathyroid hormone inhibitor in vivo: design and biological evaluation of a hormone analog (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-03
    Description: A synthetic analog of bovine parathyroid hormone (bPTH), [tyrosine-34] bPTH-(7-34)NH2, was found to inhibit parathyroid hormone action in vivo. When the analog and parathyroid hormone were infused simultaneously to rats at a molar ratio of 200 to 1, the analog inhibited the excretion of urinary phosphate and adenosine 3',5'-monophosphate. When infused alone at the same dose rate, the analog was devoid of agonist activity. The compound was prepared by following design principles developed for inhibitors of parathyroid hormone, and is believed to be the first antagonist of parathyroid hormone that is effective in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horiuchi, N -- Holick, M F -- Potts, J T Jr -- Rosenblatt, M -- AM11749/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1053-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302844" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cyclic AMP/urine ; Dose-Response Relationship, Drug ; Male ; Parathyroid Hormone/*antagonists & inhibitors/*pharmacology ; Peptide Fragments/*pharmacology ; Phosphates/urine ; Rats
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  • 162
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    Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: Depletion of polyamines in 9L rat brain tumor cells by treatment with alpha-difluoromethylornithine dramatically altered DNA conformation as measured by viscoelastometry. The reduction of intracellular putrescine and spermidine concentrations to less than 5 percent of their concentrations in control cells decreased the sensitivity of 9L cell DNA to x-irradiation and increased the maximum viscoelastic retardation time of the DNA. Both of these phenomena were reversed by addition of exogenous putrescine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hung, D T -- Marton, L J -- Deen, D F -- Shafer, R H -- CA-13525/CA/NCI NIH HHS/ -- CA-19658/CA/NCI NIH HHS/ -- CA-27343/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):368-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Neoplasms/*metabolism ; DNA, Neoplasm/*metabolism ; Eflornithine ; Molecular Conformation ; Ornithine/analogs & derivatives/pharmacology ; Polyamines/*metabolism ; Putrescine/metabolism ; Rats ; Spermidine/metabolism ; Viscosity
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  • 163
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    Protein phosphatases: properties and role in cellular regulation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingebritsen, T S -- Cohen, P -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):331-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cyclic AMP/metabolism ; Glycogen/metabolism ; Liver/enzymology ; Muscles/enzymology ; Phosphoprotein Phosphatases/classification/*physiology ; Phosphoproteins/metabolism ; Phosphorylase Phosphatase/metabolism ; Phosphorylation ; Protein Biosynthesis ; Protein Kinases/physiology ; Rabbits ; Rats
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  • 164
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    Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibbotson, K J -- D'Souza, S M -- Ng, K W -- Osborne, C K -- Niall, M -- Martin, T J -- Mundy, G R -- AM-28149/AM/NIADDK NIH HHS/ -- CA-29537/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1292-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6577602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Resorption ; Calcium ; Cells, Cultured ; Culture Media ; Growth Substances/*physiology ; Hypercalcemia/*etiology ; Leydig Cell Tumor/complications/*physiopathology ; Male ; Neoplasm Proteins/*physiology ; Neoplasms, Experimental/complications/physiopathology ; Peptides/*physiology ; Rats ; Transforming Growth Factors
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  • 165
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    Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-11
    Description: Neurons containing the enzyme aromatic-L-amino-acid decarboxylase (AADC) but lacking either tyrosine hydroxylase or serotonin were found in the spinal cord of neonatal and adult rats by light and electron microscopic immunocytochemistry. The majority of these neurons localized to area X of Rexed contact ependyma. Thus, spinal AADC neurons have the enzymatic capacity to catalyze directly the conversion of the amino acids tyrosine, tryptophan, or phenylalanine to their respective amines tyramine, tryptamine, or phenylethylamine. These amines normally present in the central nervous system may be of potential clinical significance as endogenous psychotomimetics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaeger, C B -- Teitelman, G -- Joh, T H -- Albert, V R -- Park, D H -- Reis, D J -- HL-07379-04/HL/NHLBI NIH HHS/ -- HL-18974/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6131537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aromatic-L-Amino-Acid Decarboxylases/*metabolism ; Biogenic Amines/*metabolism ; Brain/*metabolism ; Neurons/enzymology ; Neurotransmitter Agents/biosynthesis ; Rats ; Spinal Cord/*metabolism
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  • 166
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    Intermolecular interactions in collagen self-assembly as revealed by Fourier transform infrared spectroscopy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-17
    Description: When a solution of collagen molecules, at neutral pH and moderate ionic strength, is warmed from 4 degrees to 30 degrees C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aqueous media and in real time, by Fourier transform infrared spectroscopic techniques. Tentative assignments of observed spectral bands are given.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jakobsen, R J -- Brown, L L -- Hutson, T B -- Fink, D J -- Veis, A -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857249" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Collagen/*metabolism ; Connective Tissue/metabolism ; Rats ; Spectrophotometry, Infrared ; Temperature
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  • 167
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    Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-26
    Description: Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lieblich, I -- Cohen, E -- Ganchrow, J R -- Blass, E M -- Bergmann, F -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drug Tolerance ; Endorphins/physiology ; Morphine/*pharmacology ; Pain/physiopathology ; Rats ; Saccharin/*pharmacology ; Stress, Physiological/*physiopathology
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  • 168
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    Role of surface-active phospholipids in gastric cytoprotection (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-18
    Description: Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lichtenberger, L M -- Graziani, L A -- Dial, E J -- Butler, B D -- Hills, B A -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828859" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Mucosa/*physiology ; Indomethacin/pharmacology ; Phospholipids/*physiology ; Prostaglandins/physiology ; Rats ; Stomach Ulcer/physiopathology ; Surface-Active Agents
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  • 169
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    Synthesizing the opioid peptides (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/physiology ; Endorphins/*biosynthesis/genetics ; Humans ; Mice ; Nervous System Physiological Phenomena ; Pituitary Hormones, Anterior/biosynthesis/genetics ; Pro-Opiomelanocortin ; Protein Precursors/biosynthesis/genetics ; RNA, Messenger/metabolism ; Rats
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  • 170
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    A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-28
    Description: The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mendelson, W B -- Cain, M -- Cook, J M -- Paul, S M -- Skolnick, P -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294835" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbolines/*pharmacology ; Flurazepam/*antagonists & inhibitors ; Indoles/*pharmacology ; Male ; Rats ; Receptors, Cell Surface/*drug effects ; Receptors, GABA-A ; Sleep/*drug effects ; Wakefulness/drug effects
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  • 171
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    Potential role of galactokinase in neonatal carbohydrate assimilation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Glucose given to the newborn human may result in hyperglycemia, suggesting that its utilization is impaired at this developmental stage. Galactose is thought to be a more appropriate carbohydrate source for the newborn. The enzymes involved in hexose phosphorylation may, in part, be responsible for these observations. A key regulatory enzyme of hepatic glucose assimilation, glucokinase, is diminished in newborns compared to adults, whereas galactokinase activity is increased. When newborn dogs were fasted and then fed either glucose or galactose, their plasma insulin responses to glucose were similar, but the pups fed galactose demonstrated an attenuated systemic appearance rate of glucose. Hexose incorporation into hepatic glycogen and net glycogen synthesis was augmented in the galactose-fed dogs. In vitro, liver from neonatal dogs showed enhanced galactokinase activity relative to that for hexokinase or glucokinase. Neonatal hexose assimilation may be independent of insulin action and, instead, be related to the developmental presence of hexose phosphorylating enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kliegman, R M -- Miettinen, E L -- Morton, S -- HD05740/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):302-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836273" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Animals, Newborn/metabolism ; *Carbohydrate Metabolism ; Dogs ; Galactokinase/*physiology ; Galactose/metabolism ; Galactosemias ; Glucose/metabolism ; Humans ; Infant, Newborn ; Liver/enzymology ; Liver Glycogen/biosynthesis ; Phosphorylation ; Rats
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  • 172
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    Passive transfer of diabetes in the BB/W rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Severe diabetes with insulitis was produced in young diabetes-prone BB/W rats by passive transfer of concanavalin A-treated spleen cells from BB/W animals with acute diabetes. Spleen cells alone or in combination with lymph node cells were active in transferring disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koevary, S -- Rossini, A -- Stoller, W -- Chick, W -- Williams, R M -- AM-25306/AM/NIADDK NIH HHS/ -- AM-30846/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):727-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836309" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Concanavalin A/pharmacology ; Diabetes Mellitus/etiology/*immunology ; Hyperglycemia/etiology/immunology ; Immunity, Cellular ; Mice ; Mice, Nude ; Rats ; Spleen/cytology/drug effects/transplantation ; Transplantation, Heterologous ; Transplantation, Homologous
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  • 173
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    Brain-grafting work shows promise (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1277.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612340" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/surgery ; Animals ; Humans ; Memory/physiology ; Nerve Tissue/*transplantation ; Parkinson Disease/*surgery ; Rats
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  • 174
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    Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-25
    Description: Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tache, Y -- Goto, Y -- Gunion, M W -- Vale, W -- River, J -- Brown, M -- AM30110/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):935-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415815" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Brain/*drug effects ; Cerebral Cortex/drug effects ; Corticotropin-Releasing Hormone/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Gastric Acid/*secretion ; Hypophysectomy ; Hypothalamus/drug effects ; Male ; Pentagastrin/antagonists & inhibitors ; Rats ; Rats, Inbred Strains ; Thyrotropin-Releasing Hormone/antagonists & inhibitors ; Vagotomy
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  • 175
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    Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, G S -- Guyda, H J -- Posner, B I -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight/*drug effects ; Brain/drug effects/*physiology ; Eating/drug effects ; Growth Hormone/antagonists & inhibitors/blood/*physiology ; Insulin/blood/*pharmacology ; Male ; Peptides/*pharmacology ; Rats ; Rats, Inbred Strains ; Somatomedins/*pharmacology
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  • 176
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    Genetically obese mice: resistance to metastasis of B16 melanoma and enhanced T-lymphocyte mitogenic responses (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: The metastasis of B16 melanoma cells differed significantly in obese (ob/ob) and lean (+/?) female mice of strain C57BL/6J. When the mice were inoculated subcutaneously with melanoma cells at 10 to 11 months of age, the primary tumor grew more slowly in obese than in lean littermates and the frequency of lung metastasis was greatly reduced. When the mice were injected with the cells at 4 to 7 months, the primary tumor grew at the same rate in obese and lean mice, but the obese mice again showed a significantly reduced frequency of lung metastasis. That this effect was related to an enhanced immunocompetence in obese mice was supported by the finding that splenic lymphocytes of ob/ob mice showed three times the proliferative response to the T-cell mitogen concanavalin A compared with the proliferative response of lean control mice. The ob/ob mouse may provide a model for the study of enhanced immunocompetence in obese individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, C I -- Kreider, J W -- Black, P L -- Schmidt, T J -- Margules, D L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602379" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Immunity, Innate ; Lung Neoplasms/immunology ; Male ; Melanoma/*immunology ; Mice ; Mice, Inbred C57BL ; *Mice, Obese ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology ; Rats ; Receptors, Glucocorticoid/physiology ; T-Lymphocytes/*physiology
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  • 177
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    Bone cell differentiation and growth factors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-13
    Description: Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urist, M R -- DeLange, R J -- Finerman, G A -- DEO2103-17/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):680-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development ; Bone Matrix/drug effects/physiology ; Bone Morphogenetic Proteins ; Bone Neoplasms/physiopathology ; Cattle ; Cell Differentiation ; DNA, Neoplasm/metabolism ; Dogs ; Growth Substances/*physiology ; Guinea Pigs ; Haplorhini ; Humans ; Insulin-Like Growth Factor II ; Mice ; *Osteogenesis ; Osteosarcoma/physiopathology ; Proteins/pharmacology/physiology ; Rabbits ; Rats
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  • 178
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    Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-05
    Description: Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehrenberg, W B -- Baird, A -- Ling, N -- AM-18811/AM/NIADDK NIH HHS/ -- HD 09690/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408735" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Dexamethasone/pharmacology ; Drug Interactions ; Glucocorticoids/*pharmacology ; Growth Hormone/blood/secretion ; Growth Hormone-Releasing Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains
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  • 179
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    Salicylate and mitochondrial injury in Reye's syndrome (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉You, K -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):163-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzoates/pharmacology ; Benzoic Acid ; Hydroxybenzoates/pharmacology ; Microscopy, Electron ; Mitochondria, Liver/*drug effects/ultrastructure ; Mitochondrial Swelling/drug effects ; *Parabens ; Rats ; Reye Syndrome/*chemically induced ; Salicylates/*adverse effects/pharmacology
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  • 180
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    Increased brain size and cellular content in infant rats treated with an opiate antagonist (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-16
    Description: From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zagon, I S -- McLaughlin, P J -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1179-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Brain/*drug effects/growth & development/ultrastructure ; Cerebellum/drug effects ; Morphine/*antagonists & inhibitors ; Naloxone/*analogs & derivatives ; Naltrexone/*pharmacology ; Neuroglia/drug effects ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; Somatosensory Cortex/drug effects
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    Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-27
    Description: Hydroxylated derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a nigrostriatal neurotoxin in humans and primates, noncompetitively inhibited dihydropteridine reductase from human liver and rat striatal synaptosomes in vitro at micromolar concentrations. In contrast, MPTP and its chloro- and norderivatives did not inhibit this enzyme at lower than millimolar concentrations. Dihydropteridine reductase converts dihydrobiopterin to tetrahydrobiopterin, the required cofactor for the hydroxylation of aromatic amino acids during the synthesis of dopamine and serotonin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abell, C W -- Shen, R S -- Gessner, W -- Brossi, A -- HD 14635/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):405-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6608790" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Corpus Striatum/enzymology ; Dihydropteridine Reductase/*antagonists & inhibitors ; Humans ; Hydroxylation ; Liver/enzymology ; NAD/metabolism ; NADH, NADPH Oxidoreductases/*antagonists & inhibitors ; Pyridines/*pharmacology ; Rats ; Structure-Activity Relationship ; Synaptosomes/enzymology
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  • 182
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    Plasticity of substance P in mature and aged sympathetic neurons in culture (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-28
    Description: The effect of age on the plasticity of the putative peptide neurotransmitter substance P (SP) was examined in the rat superior cervical sympathetic ganglion. Explantation of ganglia from 6-month-old rats to serum-supplemented culture resulted in a tenfold increase in SP concentration, reproducing results previously obtained for ganglia from neonatal rats. Veratridine prevented the increase in SP concentration in adult ganglia, and tetrodotoxin blocked the veratridine effect, suggesting that membrane depolarization and sodium influx prevented the rise in the SP content of adult ganglia as well as of neonatal ganglia. However, the time courses of the increase in the amount of the peptide differed in neonatal and mature ganglia, suggesting that some aspects of regulation may differ in the two. The effects of aging on neural plasticity were further analyzed by explanting ganglia from 2-year-old rats. No significant increase in SP concentration was observed in these ganglia. Remarkable plasticity thus seems to persist in mature neurons but may be deficient in aged sympathetic neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, J E -- Black, I B -- HD 12108/HD/NICHD NIH HHS/ -- NS 10259/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 28;225(4669):1499-500.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206570" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Culture Techniques ; Ganglia, Sympathetic/*analysis/cytology/physiology ; *Neuronal Plasticity ; Neurons/*analysis/physiology ; Rats ; Substance P/*analysis ; Tetrodotoxin/pharmacology ; Veratridine/pharmacology
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  • 183
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    Leptospirosis in laboratory mice (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: The obituary for William A. Altemeier, Jr. (4 May, p. 525), was incorrect. Dr. Altemeier was chairman of the Department of Surgery at the University of Cincinnati.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, A D -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1158.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Laboratory/*microbiology ; Dogs ; Humans ; Leptospira ; Leptospirosis/*microbiology/transmission ; Mice ; Mice, Inbred ICR ; Primates ; Rats
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  • 184
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    Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-23
    Description: Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altura, B M -- Altura, B T -- Gebrewold, A -- Ising, H -- Gunther, T -- HL18015/HL/NHLBI NIH HHS/ -- HL29600/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701524" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arterioles/pathology ; *Blood Pressure ; Capillaries/pathology ; Magnesium/blood ; Magnesium Deficiency/pathology/*physiopathology ; Male ; *Microcirculation ; Rats ; Rats, Inbred Strains ; *Vasoconstriction ; Venules/pathology
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  • 185
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    Rapid expulsion of Trichinella spiralis in suckling rats (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-05
    Description: Orally administered Trichinella spiralis muscle larvae were rapidly expelled by rat pups suckling an immune dam. The immunity was delivered in the milk; substantial resistance was conferred on normal rat pups suckled for only 24 hours by a Trichinella-immune foster mother. The pups were protected by oral or systemic administration of specific serum antibodies. When infused into a normal lactating dam, these antibodies accumulated in the serum of her suckling pups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Appleton, J A -- McGregor, D D -- AI 14490/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 5;226(4670):70-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling ; Antibodies/immunology ; Colostrum/immunology ; Female ; *Immunity, Maternally-Acquired ; Immunization, Passive ; Intestinal Diseases, Parasitic/*immunology/parasitology ; Intestinal Mucosa/parasitology ; Milk/*immunology ; Rats ; Trichinella/*immunology/physiology ; Trichinellosis/*immunology/parasitology
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  • 186
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    Inhibition of aldosterone production by an atrial extract (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atarashi, K -- Mulrow, P J -- Franco-Saenz, R -- Snajdar, R -- Rapp, J -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):992-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326267" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/pharmacology ; Aldosterone/*biosynthesis ; Angiotensin II/pharmacology ; Animals ; *Atrial Function ; Dogs ; Female ; Kidney/drug effects/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Natriuresis/drug effects ; Rats ; Rats, Inbred Strains ; Trypsin/pharmacology
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  • 187
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    Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: A novel eukaryotic hybrid gene has been constructed from the 5' sequence of a rat gene and the bacterial neomycin-resistance gene. After transfection into hamster fibroblasts, the neo transcripts can be induced to high levels by the absence of glucose. Furthermore, this hybrid gene can be regulated by temperature when it is introduced into a temperature-sensitive mutant cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attenello, J W -- Lee, A S -- CA-27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):187-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cricetinae ; DNA, Recombinant ; Drug Resistance, Microbial ; Fibroblasts ; *Gene Expression Regulation ; Genes, Bacterial ; *Genes, Regulator ; Glucose/*pharmacology ; *HSP70 Heat-Shock Proteins ; Membrane Proteins/biosynthesis/*genetics ; Mutation ; Neomycin/pharmacology ; Rats ; Temperature ; Transcription, Genetic ; Transfection
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  • 188
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    Fast and slow magnetic phenomena in focal epileptic seizures (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: The magnetic fields associated with penicillin-induced focal epilepsy were measured in laboratory rats. Interictal magnetic spikes were similar to those previously observed in humans with focal seizure disorders. The magnetic fields of the seizure itself displayed both slow and fast phenomena, reversing in direction on opposite sides of the head.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barth, D S -- Sutherling, W -- Beatty, J -- 1-R01-NS20806-01/NS/NINDS NIH HHS/ -- 1K07NS00678-01A1/NS/NINDS NIH HHS/ -- 5-S07 RR07009/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):855-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroencephalography ; *Electromagnetic Fields ; *Electromagnetic Phenomena ; Electrophysiology ; Epilepsies, Partial/*physiopathology ; Humans ; Penicillins/pharmacology ; Rats ; Rats, Inbred Strains ; Seizures/physiopathology
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  • 189
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    Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baekkeskov, S -- Dyrberg, T -- Lernmark, A -- AM26190/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1348-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6374896" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/*immunology ; Diabetes Mellitus, Experimental/*immunology ; Diabetes Mellitus, Type 1/immunology ; Humans ; Islets of Langerhans/*immunology ; Rats ; Rats, Inbred Strains ; Rats, Mutant Strains
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  • 190
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    Induction of pituitary lactotrope differentiation by luteinizing hormone alpha subunit (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: Addition of gonadotropin releasing hormone to cultures of fetal rat pituitary induced differentiation of lactotropes as revealed by immunocytochemistry. Antiserum to luteinizing hormone (LH) (recognizing native LH), but not antiserum to LH-beta (recognizing both native LH and its beta subunit), inhibited this induction. Further addition of highly purified LH-alpha subunit in culture medium also induced lactotrope differentiation. Thus, the alpha subunit may have a specific biological activity of its own with probable practical use in clinical investigations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Begeot, M -- Hemming, F J -- Dubois, P M -- Combarnous, Y -- Dubois, M P -- Aubert, M L -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):566-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6208610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fetus/physiology ; Glycoprotein Hormones, alpha Subunit ; Humans ; Luteinizing Hormone/immunology/pharmacology/physiology ; Peptide Fragments/*pharmacology/physiology ; Pituitary Gland/*drug effects/growth & development ; Pituitary Hormone-Releasing Hormones/pharmacology ; Pituitary Hormones, Anterior/*pharmacology/physiology ; Rats
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  • 191
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    Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Bromodeoxyuridine (BrdUrd) treatment of the prolactin nonproducing subclone of GH cells (rat pituitary tumor cells) induces amplification of a 20-kilobase DNA fragment including all of the prolactin gene coding sequences. This amplified DNA segment, which is flanked by two unamplified regions, thus designates a unit of BrdUrd-induced amplified sequence. Cloned DNA segments, 10.3 kilobases long, from the 5' end of the rat prolactin gene of BrdUrd-responsive and -nonresponsive cells, were ligated to the thymidine kinase gene of herpes simplex virus type 1 (HSV1TK), and the hybrid DNA was transferred to thymidine kinase-deficient mouse fibroblast cells by transfection. The HSV1TK gene and the rat prolactin gene were amplified together in drug-treated transfectants carrying the hybrid DNA HSV1TK gene and rat prolactin gene of BrdUrd-responsive GH cells. These results suggest that the 10.3-kilobase DNA segment at the 5' end of the rat prolactin gene of BrdUrd-responsive GH cells carries the information for drug-induced gene amplification (amplicon) and that another gene, such as the HSV1TK gene, is also amplified when the latter is placed adjacent to this segment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biswas, D K -- Hartigan, J A -- Pichler, M H -- CA28218/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):941-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089335" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Bromodeoxyuridine/*pharmacology ; Cell Line ; Cloning, Molecular ; DNA/*genetics ; DNA, Recombinant ; *Gene Amplification ; Genes, Viral ; Mice ; Prolactin/genetics ; Rats ; Simplexvirus/genetics ; Thymidine Kinase/genetics ; Transfection
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  • 192
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    Interrelated striated elements in vestibular hair cells of the rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Unusual fixation procedures revealed a series of interrelated striated organelles in type I and type II vestibular hair cells of the rat; these organelles seemed to be less well developed in cochlear hair cells. The findings suggest that contractile elements may play a role in sensory transduction in the inner ear, particularly in the vestibular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M D -- Bourne, C -- New York, N.Y. -- Science. 1983 May 6;220(4597):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682246" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Cell Membrane/ultrastructure ; Cytoskeleton/ultrastructure ; Hair Cells, Auditory/*ultrastructure ; Microscopy, Electron ; Organoids/ultrastructure ; Rats ; Rats, Inbred Strains
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  • 193
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    Anatomically distinct opiate receptor fields mediate reward and physical dependence (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Rats never before exposed to opioids rapidly learned to press a lever for microinjections of morphine into the ventral tegmental area. Challenge by a narcotic antagonist produced no signs of physical dependence. Dependence was not seen after long-term morphine infusions into the ventral tegmentum but was seen after similar infusions into the periventricular gray region. Thus a major rewarding property of morphine is independent of the drug's ability to produce physical dependence. These data challenge models of drug addiction that propose physical dependence as necessary for the rewarding effects of opioids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bozarth, M A -- Wise, R A -- New York, N.Y. -- Science. 1984 May 4;224(4648):516-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6324347" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Humans ; Microinjections ; Morphine/*pharmacology ; *Morphine Dependence ; Naloxone/pharmacology ; Rats ; Receptors, Opioid/*physiology ; *Reward
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  • 194
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 195
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    Polyene toxicity in renal medulla: injury mediated by transport activity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and thus increase the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited oxygen supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances thus appears to be mediated by increased oxygen demand for transport activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brezis, M -- Rosen, S -- Silva, P -- Spokes, K -- Epstein, F H -- AM18078/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322305" target="_blank"〉PubMed〈/a〉
    Keywords: Amphotericin B/adverse effects ; Animals ; Biological Transport, Active/drug effects ; Cell Membrane Permeability/drug effects ; Furosemide/pharmacology ; Glomerular Filtration Rate/drug effects ; Kidney Medulla/*drug effects/pathology ; Loop of Henle/drug effects ; Nystatin/adverse effects ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Polyenes/*adverse effects ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 196
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    Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-21
    Description: A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical, and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids. Its qualities as a neurotoxic agent suggest that quinolinic acid should be considered as a possible pathogenic factor in neurodegenerative disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarcz, R -- Whetsell, W O Jr -- Mangano, R M -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849138" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/drug effects ; Brain/*drug effects/enzymology ; Corpus Striatum/drug effects/enzymology/ultrastructure ; Hippocampus/drug effects ; Neuroglia/drug effects ; Neurons/drug effects ; Pyridines/*pharmacology ; Quinolinic Acids/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 197
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    Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-08
    Description: Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R D -- Kellar, K J -- 507 RR05360-20/RR/NCRR NIH HHS/ -- GM07443/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828889" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Brain/*physiology ; Brain Chemistry/drug effects ; Cerebral Cortex/analysis/physiology ; Isoflurophate/pharmacology ; Male ; Nicotine/metabolism/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*physiology ; Receptors, Nicotinic/analysis/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 198
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    Gene transfer by polyoma-like particles assembled in a cell-free system (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Empty capsids of polyoma virus interact with DNA in a cell-free system to form polyoma-like particles (PLP). The DNA in these particles is protected from the action of pancreatic deoxyribonuclease. Transfer of genetic information by PLP has been accomplished by using a restriction fragment containing the transforming sequences of polyoma DNA as a model gene. Infection of rat F111 cells by PLP containing these sequences results in DNA-mediated cellular transformation. Gene transfer by PLP is 50 to 150 times more efficient than by the calcium phosphate precipitation method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slilaty, S N -- Aposhian, H V -- New York, N.Y. -- Science. 1983 May 13;220(4598):725-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Viral ; Cell-Free System ; DNA/genetics/*metabolism ; DNA, Viral/genetics/metabolism ; Genes, Viral ; Polyomavirus/*genetics ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 199
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    Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-04
    Description: A soluble extract of rat skeletal muscle increased neurite outgrowth and cholinergic activity of dissociated ventral spinal neurons in culture. The effects were concentration-dependent, saturable, and labile in the presence of heat or trypsin. The morphological enhancement was produced only by skeletal muscle extract and decreased with developmental age, whereas the cholinergic enhancement was produced by extracts of cerebral cortex and cardiac and skeletal muscle and did not change with age. These changes were specific for ventral cord neurons, but no species specificity was observed with respect to the muscle source or the neuronal target.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R G -- Appel, S H -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823568" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*biosynthesis ; Animals ; Ganglia, Spinal/cytology ; Motor Neurons/*growth & development/metabolism ; Muscles/embryology/*physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 200
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    Essential role of insulin in transcription of the rat 25,000 molecular weight casein gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-14
    Description: Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chomczynski, P -- Qasba, P -- Topper, Y J -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1326-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390680" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caseins/biosynthesis/*genetics ; Culture Techniques ; *Gene Expression Regulation ; Half-Life ; Hydrocortisone/physiology ; Insulin/*physiology ; Mammary Glands, Animal/metabolism ; Molecular Weight ; Prolactin/physiology ; RNA, Messenger/physiology ; Rats ; Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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