Publication Date:
2011-07-19
Description:
Reward-motivated behavior is strongly influenced by the learned significance of contextual stimuli in the environment. However, the neural pathways that mediate context-reward relations are not well understood. We have identified a circuit from area CA3 of dorsal hippocampus to ventral tegmental area (VTA) that uses lateral septum (LS) as a relay. Theta frequency stimulation of CA3 excited VTA dopamine (DA) neurons and inhibited non-DA neurons. DA neuron excitation was likely mediated by disinhibition because local antagonism of gamma-aminobutyric acid receptors blocked responses to CA3 stimulation. Inactivating components of the CA3-LS-VTA pathway blocked evoked responses in VTA and also reinstatement of cocaine-seeking by contextual stimuli. This transsynaptic link between hippocampus and VTA appears to be an important substrate by which environmental context regulates goal-directed behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150711/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150711/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luo, Alice H -- Tahsili-Fahadan, Pouya -- Wise, Roy A -- Lupica, Carl R -- Aston-Jones, Gary -- F31-MH071093/MH/NIMH NIH HHS/ -- R37 DA006214/DA/NIDA NIH HHS/ -- R37-DA006214/DA/NIDA NIH HHS/ -- UL1 RR029882/RR/NCRR NIH HHS/ -- ZIA DA000471-07/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):353-7. doi: 10.1126/science.1204622.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral Neuroscience Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. alice_luo@hotmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764750" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Behavior, Animal
;
Brain Mapping
;
CA3 Region, Hippocampal/*physiology
;
Cocaine/administration & dosage
;
Dopamine/physiology
;
Drug-Seeking Behavior
;
Electric Stimulation
;
GABA Agonists/pharmacology
;
GABA Antagonists/pharmacology
;
Hippocampus/physiology
;
Male
;
Models, Neurological
;
Neural Inhibition
;
Neural Pathways
;
Neurons/*physiology
;
Rats
;
Rats, Sprague-Dawley
;
*Reward
;
Self Administration
;
Septal Nuclei/*physiology
;
Theta Rhythm
;
Ventral Tegmental Area/*physiology
;
gamma-Aminobutyric Acid/administration & dosage/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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