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  • Chemistry  (131,356)
  • AERODYNAMICS  (6,187)
  • 1990-1994  (53,665)
  • 1980-1984  (35,806)
  • 1970-1974  (28,421)
  • 1950-1954  (9,239)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waldrop, M M -- New York, N.Y. -- Science. 1990 Aug 3;249(4968):472-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2382127" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Information Systems ; Jurisprudence ; Societies, Scientific ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1991-10-25
    Description: The presence of clathrate hydrates in cometary ice has been suggested to account for anomalous gas release at large radial distances from the sun as well as the retention of volatiles in comets to elevated temperatures. However, how clathrate hydrates can form in low-pressure environments, such as in cold interstellar molecular clouds, in the outer reaches of the early solar nebula, or in cometary ices, has been poorly understood. Experiments performed with the use of a modified electron microscope demonstrate that during the warming of vapor-deposited amorphous ices in vacuo, clathrate hydrates can form by rearrangements in the solid state. Phase separations and microporous textures that are the result of these rearrangements may account for a variety of anomalous cometary phenomena.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blake, D -- Allamandola, L -- Sandford, S -- Hudgins, D -- Freund, F -- New York, N.Y. -- Science. 1991 Oct 25;254:548-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Planetary Biology Branch, Ames Research Center, Moffett Field, CA 94035, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11538372" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Crystallography ; Earth (Planet) ; Hydrocarbons/chemistry ; Ice/*analysis ; *Meteoroids ; Microscopy, Electron ; *Solar System
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: Direct osmotic stress measurements have been made of forces between helices of xanthan, an industrially important charged polysaccharide. Exponentially decaying hydration forces, much like those already measured between lipid bilayer membranes or DNA double helices, dominate the interactions at close separation. Interactions between uncharged schizophyllans also show the same kind of hydration force seen between xanthans. In addition to the practical possibilities for modifying solution and suspension properties through recognition and control of molecular forces, there is now finally the opportunity for theorists to relate macroscopic properties of a polymer solution to the microscopic properties that underlie them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rau, D C -- Parsegian, V A -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1278-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institues of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2144663" target="_blank"〉PubMed〈/a〉
    Keywords: Carbohydrate Sequence ; Chemical Phenomena ; Chemistry ; Gels ; *Glycosaminoglycans ; Macromolecular Substances ; Molecular Sequence Data ; Osmosis ; *Polysaccharides, Bacterial ; *Sizofiran ; Solutions ; Viscosity
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-02
    Description: Protein unfolding and the dissolution of hydrophobic compounds (including solids, liquids, and gases) in water are characterized by a linear relation between entropy change and heat capacity change. The same slope is found for various classes of compounds, whereas the intercept depends on the particular class. The feature common to these processes is exposure of hydrophobic groups to water. These observations make possible the assignment of the heat capacity change to hydrophobic solvation and lead to the description of protein stability in terms of a hydrophobic and a nonhydrophobic contribution. A general representation of protein stability is given by the heat capacity change and the temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, K P -- Privalov, P L -- Gill, S J -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):559-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2300815" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Protein Denaturation ; *Proteins ; Thermodynamics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-02
    Description: Ultrasound has become an important synthetic tool in liquid-solid chemical reactions, but the origins of the observed enhancements remained unknown. The effects of high-intensity ultrasound on solid-liquid slurries were examined. Turbulent flow and shock waves produced by acoustic cavitation were found to drive metal particles together at sufficiently high velocities to induce melting upon collision. A series of transition-metal powders were used to probe the maximum temperatures and speeds reached during such interparticle collisions. Metal particles that were irradiated in hydrocarbon liquids with ultrasound underwent collisions at roughly half the speed of sound and generated localized effective temperatures between 2600 degrees C and 3400 degrees C at the point of impact for particles with an average diameter of approximately 10 microns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doktycz, S J -- Suslick, K S -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1067-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Chemical Sciences, University of Illinois, Urbana 61801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2309118" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Metals ; Microscopy, Electron, Scanning ; Microspheres ; *Ultrasonics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-01-12
    Description: Experiments are presented that confirm earlier predictions that the mode of supply of reactants to a nonlinear (bio)chemical reaction determines or controls concentrations at steady states far from equilibrium. The oxidation of nicotinamide adenine dinucleotide (NADH) catalyzed by the enzyme horseradish peroxidase with continuous input of oxygen was studied; NAD+ is continuously recycled to NADH through a glucose-6-phosphate dehydrogenase system. A comparison of steady-state concentrations is made with an oscillatory oxygen input and a constant input at the same average oxygen input for both modes. By varying the frequency and amplitude of the perturbation (O2 influx), the following may be changed: the average concentration of NADH; the Gibbs free energy difference delta G of the reactants and products at steady state; the average rate of the reaction; the phase relation between the oscillatory rate and delta G; and the dissipation. These results confirm the possibility of an "alternating current chemistry," of control and optimization of thermodynamic efficiency and dissipation by means of external variation of constraints in classes of nonlinear reactions and biological pumps, and of improvements of the yield in such reactions (heterogeneous catalysis, for example).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazar, J G -- Ross, J -- New York, N.Y. -- Science. 1990 Jan 12;247(4939):189-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2294601" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Chemical Phenomena ; Chemistry ; Glucosephosphate Dehydrogenase/*metabolism ; Horseradish Peroxidase/*metabolism ; Kinetics ; NAD/*metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Peroxidases/*metabolism ; Thermodynamics
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  • 7
    Publication Date: 1990-08-17
    Description: The interaction of a protein antigen, horse cytochrome c (cyt c), with a monoclonal antibody has been studied by hydrogen-deuterium (H-D) exchange labeling and two-dimensional nuclear magnetic resonance (2D NMR) methods. The H-exchange rate of residues in three discontiguous regions of the cyt c polypeptide backbone was slowed by factors up to 340-fold in the antibody-antigen complex compared with free cyt c. The protected residues, 36 to 38, 59, 60, 64 to 67, 100, and 101, and their hydrogen-bond acceptors, are brought together in the three-dimensional structure to form a contiguous, largely exposed protein surface with an area of about 750 square angstroms. The interaction site determined in this way is consistent with prior epitope mapping studies and includes several residues that were not previously identified. The hydrogen exchange labeling approach can be used to map binding sites on small proteins in antibody-antigen complexes and may be applicable to protein-protein and protein-ligand interactions in general.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432411/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432411/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paterson, Y -- Englander, S W -- Roder, H -- GM 31847/GM/NIGMS NIH HHS/ -- GM 35926/GM/NIGMS NIH HHS/ -- R01 GM031847/GM/NIGMS NIH HHS/ -- S07-RR-05415-28/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1990 Aug 17;249(4970):755-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Pennsylvania, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1697101" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology/metabolism ; Antigen-Antibody Complex ; *Binding Sites, Antibody ; Chemical Phenomena ; Chemistry ; Cytochrome c Group/*immunology ; Deuterium ; Epitopes/immunology ; Hydrogen/*metabolism ; Hydrogen Bonding ; Kinetics ; *Magnetic Resonance Spectroscopy ; Molecular Structure ; Protein Conformation
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1991-07-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baskin, Y -- New York, N.Y. -- Science. 1991 Jul 12;253(5016):140-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1853198" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Biology ; California ; Chemical Phenomena ; Chemistry ; Research Support as Topic
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-23
    Description: Reactive or unstable molecules are key intermediates in many important reactions, but can be difficult to prepare for experimental studies. Species with missing (:CH-OH) or extra (H3) substituents can often be formed conveniently in the gas phase by neutralizing a beam of a more stable ionic counterpart (CH = O+H, H3+). Reionization of the neutral after approximately 10(-6) seconds tests its stability, whereas its unimolecular chemistry can be probed by preparing it with different amounts of internal energy. The resulting neutral products are reionized and mass analyzed. Isomers are then characterized by ion dissociation and a third mass-analysis step. Many unusual molecules have been characterized with this technique, which can also be used to probe complex unimolecular chemistry, such as that of cyclobutadiene and ethylene oxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLafferty, F W -- GM-16609/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Feb 23;247(4945):925-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cornell University, Baker Laboratory, Ithaca, NY 14853-1301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2305261" target="_blank"〉PubMed〈/a〉
    Keywords: Butadienes ; Chemical Phenomena ; Chemistry ; Ethylene Oxide ; Free Radicals ; Hydrocarbons ; *Ions ; *Mass Spectrometry ; Methane/analogs & derivatives ; Molecular Structure ; Thermodynamics
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  • 10
    Publication Date: 1990-05-18
    Description: The immunosuppressive agents cyclosporin A and FK506 inhibit the transcription of early T cell activation genes. The binding proteins for cyclosporin A and FK506, cyclophilin and FKBP, respectively, are peptidyl-prolyl-cis-trans isomerases, or rotamases. One proposed mechanism for rotamase catalysis by cyclophilin involves a tetrahedral adduct of an amide carbonyl and an enzyme-bound nucleophile. The potent FKBP rotamase inhibitor FK506 has a highly electrophilic carbonyl that is adjacent to an acyl-pipicolinyl (homoprolyl) amide bond. Such a functional group would be expected to form a stabilized, enzyme-bound tetrahedral adduct. Spectroscopic and chemical evidence reveals that the drug interacts noncovalently with its receptor, suggesting that the alpha-keto amid of FK506 serves as a surrogate for the twisted amide of a bound peptide substrate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosen, M K -- Standaert, R F -- Galat, A -- Nakatsuka, M -- Schreiber, S L -- GM-38627/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 May 18;248(4957):863-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1693013" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Isomerases/*antagonists & inhibitors ; Anti-Bacterial Agents/metabolism/*pharmacology ; Binding Sites ; Carrier Proteins/antagonists & inhibitors/metabolism ; Chemical Phenomena ; Chemistry ; Cloning, Molecular ; Cyclosporins/metabolism/pharmacology ; Escherichia coli/genetics ; Gene Expression ; *Immunosuppressive Agents ; Lymphocyte Activation ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Peptidylprolyl Isomerase ; Recombinant Proteins ; T-Lymphocytes/immunology ; Tacrolimus
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1991-05-03
    Description: Immunochemistry has historically focused on the nature of antigenicity and antibody-antigen recognition. However, in the last 5 years, the field of immunochemistry has taken a new direction. With the aid of mechanistic and synthetic chemistry, the vast network of molecules and cells of the immune system has been tapped to produce antibodies with a new function--catalytic antibodies. Because antibodies can be generated that selectively bind almost any molecule of interest, this new technology offers the potential to tailor-make highly selective catalysts for applications in biology, chemistry, and medicine. In addition, catalytic antibodies provide fundamental insight into important aspects of biological catalysis, including the importance of transition-state stabilization, proximity effects, general acid and base catalysts, electrophilic and nucleophilic catalysis, and strain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lerner, R A -- Benkovic, S J -- Schultz, P G -- New York, N.Y. -- Science. 1991 May 3;252(5006):659-67.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2024118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies/chemistry/immunology/metabolism ; Antibodies, Monoclonal/immunology/metabolism ; Antibody Specificity ; Antigens/chemistry/immunology/metabolism ; Binding Sites, Antibody ; *Catalysis ; Chemical Phenomena ; Chemistry ; Haptens ; Hydrogen-Ion Concentration ; Hydrolysis ; Metals ; Molecular Conformation ; Recombinant Proteins ; Thermodynamics ; Zinc
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flam, F -- New York, N.Y. -- Science. 1994 Apr 1;264(5155):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8140417" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*chemical synthesis/immunology ; Animals ; Antibodies, Viral/biosynthesis ; Cellobiose ; Chemistry ; HIV Antibodies/biosynthesis ; Herpesvirus 4, Human/*immunology ; Societies, Scientific ; *Vaccines, Synthetic/immunology ; Viral Proteins ; Viral Vaccines/*chemical synthesis/immunology
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1992-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crease, R P -- New York, N.Y. -- Science. 1992 Feb 28;255(5048):1065-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1546307" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; Chemical Phenomena ; Chemistry ; Humans ; Sociology ; *Women, Working
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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  • 15
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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  • 23
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 24
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 26
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 28
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 29
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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  • 30
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 33
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 34
    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 37
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
    Print ISSN: 0036-8075
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 44
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 45
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
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  • 47
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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  • 48
    Publication Date: 2011-10-14
    Description: The test capabilities of the Stability Wind Tunnel of the Virginia Polytechnic Institute and State University are described, and calibrations for curved and rolling flow techniques are given. Oscillatory snaking tests to determine pure yawing derivatives are considered. Representative aerodynamic data obtained for a current fighter configuration using the curved and rolling flow techniques are presented. The application of dynamic derivatives obtained in such tests to the analysis of airplane motions in general, and to high angle of attack flight conditions in particular, is discussed.
    Keywords: AERODYNAMICS
    Type: AGARD Dyn. Stability Parameters; 13 p
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  • 49
    Publication Date: 2011-08-24
    Description: The compressible dynamic stall flowfield over a NACA 0012 airfoil transiently pitching from 0 to 60 deg at a constant rate under compressible flow conditions has been studied using real-time interferometry. A quantitative description of the overall flowfield, including the finer details of dynamic stall vortex formation, growth, and the concomitant changes in the airfoil pressure distribution, has been provided by analyzing the interferograms. For Mach numbers above 0.4, small multiple shocks appear near the leading edge and are present through the initial stages of dynamic stall. Dynamic stall was found to occur coincidentally with the bursting of the separation bubble over the airfoil. Compressibility was found to confine the dynamic stall vortical structure closer to the airfoil surface. The measurements show that the peak suction pressure coefficient drops with increasing freestream Mach number, and also it lags the steady flow values at any given angle of attack. As the dynamic stall vortex is shed, an anti-clockwise vortex is induced near the trailing edge, which actively interacts with the post-stall flow.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 3; p. 586-593
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  • 50
    Publication Date: 2011-08-24
    Description: The effect of the porous leading edge of an airfoil on the blade-vortex interaction noise, which dominates the far-field acoustic spectrum of the helicopter, is investigated. The thin-layer Navier-Stokes equations are solved with a high-order upwind-biased scheme and a multizonal grid system. The Baldwin-Lomax turbulence model is modified for considering transpiration on the surface. The amplitudes of the propagating acoustic wave in the near field are calculated directly from the computation. The porosity effect on the surface is modeled in two ways: (1) imposition of prescribed transpiration velocity distribution and (2) calculation of transpiration velocity distribution by Darcy's law. Results show leading-edge transpiration can suppress pressure fluctuations at the leading edge during blade-vortex interaction and consequently reduce the amplitude of propagating noise by 30% at a maximum in the near field.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 3; p. 480-488
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  • 51
    Publication Date: 2011-08-24
    Description: A method has been developed for calculating the viscous flow about airfoils with and without deflected flaps at -90 deg incidence. This method provides for the solution of the unsteady incompressible Navier-Stokes equations by means of an implicit technique. The solution is calculated on a body-fitted computational mesh using a staggered-grid method. The vorticity is defined at the node points, and the velocity components are defined at the mesh-cell sides. The staggered-grid orientation provides for accurate representation of vorticity at the node points and the continuity equation at the mesh-cell centers. The method provides for the noniterative solution of the flowfield and satisfies the continuity equation to machine zero at each time step. The method is evaluated in terms of its stability to predict two-dimensional flow about an airfoil at -90-deg incidence for varying Reynolds number and laminar/turbulent models. The variations of the average loading and surface pressure distribution due to flap deflection, Reynolds number, and laminar or turbulent flow are presented and compared with experimental results. The comparisom indicate that the calculated drag and drag reduction caused by flap deflection and the calculated average surface pressure are in excellent agreement with the measured results at a similar Reynolds number.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 3; p. 449-454
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  • 52
    Publication Date: 2011-08-24
    Description: Rotor noise prediction codes predict the thickness and loading noise produced by a helicopter rotor, given the blade motion, rotor operating conditions, and fluctuating force distribution over the blade surface. However, the criticality of these various inputs, and their respective effects on the predicted acoustic field, have never been fully addressed. This paper examines the importance of these inputs, and the sensitivity of the acoustic predicitions to a variation of each parameter. The effects of collective and cyclic pitch, as well as coning and cyclic flapping, are presented. Blade loading inputs are examined to determine the necessary spatial and temporal resolution, as well as the importance of the chordwise distribution. The acoustic predictions show regions in the acoustic field where significant errors occur when simplified blade motions or blade loadings are used. An assessment of the variation in the predicted acoustic field is balanced by a consideration of Central Processing Unit (CPU) time necessary for the various approximations.
    Keywords: AERODYNAMICS
    Type: American Helicopter Society, Journal (ISSN 0002-8711); 39; 3; p. 43-52
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  • 53
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    Publication Date: 2011-08-24
    Description: The U.S. National Aeronautics and Space Administration (NASA) Balloon Program has been highly successful since recovering from the catastrophic balloon failure problems of the early to mid 1980s. Balloons have continued to perform at unprecedented success rates. The comprehensive research and development (R&D) effort has continued with advances being made across the spectrum of balloon related disciplines. The long duration balloon project will be transitioning from a development effort to an operational capability this year. Recently, emphasis has been placed on the development and implementation of new support systems and facilities. A new permanent launch facility at Fort Sumner, New Mexico has been established. New ground station support equipment is being implemented, and a new heavy load launch vehicle is scheduled to be implemented in 1992. The progress, status and future plans for these and other aspects of the NASA program will be presented.
    Keywords: AERODYNAMICS
    Type: Advances in Space Research (ISSN 0273-1177); 14; 2; p. (2)129-(2)135
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  • 54
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    Publication Date: 2011-08-24
    Description: The catastrophic balloon failure during the first half of the 1980's identified the need for a comprehensive and continuing balloon research and development (R&D) commitment by NASA. Technical understanding was lacking in many of the disciplines and processes associated with scientific ballooning. A comprehensive balloon R&D plan was developed in 1986 and implemented in 1987. The objectives were to develop the understanding of balloon system performance, limitations, and failure mechanisms. The program consisted of five major technical areas: structures, performance and analysis, materials, chemistry and processing, and quality control. Research activitites have been conducted at NASA/Goddard Space Flight Center (GSFC)-Wallops Flight Facility (WFF), other NASA centers and government facilities, universities, and the balloon manufacturers. Several new and increased capabilities and resources have resulted from this activity. The findings, capabilities, and plan of the balloon R&D program are presented.
    Keywords: AERODYNAMICS
    Type: Advances in Space Research (ISSN 0273-1177); 14; 2; p. (2)137-(2)146
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  • 55
    Publication Date: 2011-08-24
    Description: Caps have been used to structurally reinforce scientific research balloons since the late 1950's. The scientific research balloons used by the National Aeronautics and Space Administration (NASA) use internal caps. A NASA cap placement specification does not exist since no empirical information exisits concerning cap placement. To develop a cap placement specification, NASA has completed two in-hangar inflation tests comparing the structural contributions of internal caps and external caps. The tests used small scale test balloons designed to develop the highest possible stresses within the constraints of the hangar and balloon materials. An externally capped test balloon and an internally capped test balloon were designed, built, inflated and simulated to determine the structural contributions and benefits of each. The results of the tests and simulations are presented.
    Keywords: AERODYNAMICS
    Type: Advances in Space Research (ISSN 0273-1177); 14; 2; p. (2)49-(2)52
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  • 56
    Publication Date: 2011-08-24
    Description: The purpose of this Note is to present results from an analytic/experimental study that investigated the potential for passively changing blade twist through the use of extension-twist coupling. A set of composite model rotor blades was manufactured from existing blade molds for a low-twist metal helicopter rotor blade, with a view toward establishing a preliminary proof concept for extension-twist-coupled rotor blades. Data were obtained in hover for both a ballasted and unballasted blade configuration in sea-level atmospheric conditions. Test data were compared with results obtained from a geometrically nonlinear analysis of a detailed finite element model of the rotor blade developed in MSC/NASTRAN.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 7; p. 1549-1551
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  • 57
    Publication Date: 2011-08-24
    Description: The paper considers the compressible Rayleigh equation as a model for the Mach wave emission mechanism associated with high-temperature supersonic jets. Solutions to the compressible Rayleigh equation reveal the existence of several families of supersonically convecting instability waves. These waves directly radiate noise to the jet far field. The predicted noise characteristics are compared to previously acquired experimental data for an axisymmetric Mach 2 fully pressure balanced jet operating over a range of jet total temperatures from ambient to 1370 K. The results of this comparison show that the first-order supersonic instability wave and the Kelvin-Hemlhlotz first-, second-, and third-order modes have directional radiation characteristics that are in agreement with observed data. The assumption of equal initial amplitudes for all of the waves leads to the conclusion that the flapping mode of instability dominates the noise radiatio process of supersonic jets. At a jet temperature of 1370 K, supersonic instability waves are predicted to dominate the noise radiated at high frequency at narrow angles to the jet axis.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 12; p. 2345-2350
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  • 58
    Publication Date: 2011-08-24
    Description: The objective of the present work is to study the mixing characteristics of a linear array of supersonic rectangular jets under conditions of screech synchronization. The screech synchronization at a fully expanded jet Mach number of 1.61 is achieved by a precise adjustment of the internozzle spacing. To our knowledge, such an experiment on the resonant mixing of screech synchronized multiple rectangular jets has not been reported before. The results are compared with the case where the screech was suppressed in the multijet configuration.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 12; p. 2477-2480
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  • 59
    Publication Date: 2011-08-24
    Description: The objective of the present investigation is to assess the effect of the spatial order of accuracy used for the evaluation of the inviscid fluxes on the resolution of higher order quantitites, such as velocity gradients. The viscous terms are computed as second-order accurate with central difference formulas, even though for the explicit part of the algorithm higher order approximations may be used. A viscous/inviscid method is used, and the outer part of the flowfield is computed with the inviscid flow equations. The viscous boundary-layer type flow region close to the body surface is computed with an algebraic eddy viscosity model. Results obtained with the conservative and nonconservative formulations and the viscous/inviscid approach are compared with available experimental data. The effect of grid refinement on the accuracy of the solution is also presented.
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 32; 12; p. 2471-2474
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  • 60
    Publication Date: 2011-08-24
    Description: The benefits of using a hypersonic waverider for spacecraft trajectory modification are presented. A waverider is a hypersonic vehicle specifically designed so that the undersurface bow shock is attached to the leading edge, which provides for the highest known lift-to-drag ratios achievable at high Mach number flight. Several viable space missions are suggested which could use such configurations for low-drag aero-assisted maneuvers in planetary atmospheres. It is shown that large changes in the spacecraft velocity vector can be accomplished with acceptably small losses in energy due to drag using a waverider aeroshell. The primary advantage of an aero-assist maneuver is suggested by comparison to a traditional gravity-assist trajectory. Some scaling laws are presented for comparing waveriders designed for different planetary atmospheres, and it is shown that the compositional differences between the terrestrial planets has a minimal impact on waverider design.
    Keywords: AERODYNAMICS
    Type: British Interplanetary Society, Journal (ISSN 0007-094X); 46; 1; p. 11-20
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  • 61
    Publication Date: 2011-08-24
    Description: ARC2D is a computational fluid dynamics program developed at the NASA Ames Research Center specifically for airfoil computations. The program uses implicit finite-difference techniques to solve two-dimensional Euler equations and thin layer Navier-Stokes equations. It is based on the Beam and Warming implicit approximate factorization algorithm in generalized coordinates. The methods are either time accurate or accelerated non-time accurate steady state schemes. The evolution of the solution through time is physically realistic; good solution accuracy is dependent on mesh spacing and boundary conditions. The mathematical development of ARC2D begins with the strong conservation law form of the two-dimensional Navier-Stokes equations in Cartesian coordinates, which admits shock capturing. The Navier-Stokes equations can be transformed from Cartesian coordinates to generalized curvilinear coordinates in a manner that permits one computational code to serve a wide variety of physical geometries and grid systems. ARC2D includes an algebraic mixing length model to approximate the effect of turbulence. In cases of high Reynolds number viscous flows, thin layer approximation can be applied. ARC2D allows for a variety of solutions to stability boundaries, such as those encountered in flows with shocks. The user has considerable flexibility in assigning geometry and developing grid patterns, as well as in assigning boundary conditions. However, the ARC2D model is most appropriate for attached and mildly separated boundary layers; no attempt is made to model wake regions and widely separated flows. The techniques have been successfully used for a variety of inviscid and viscous flowfield calculations. The Cray version of ARC2D is written in FORTRAN 77 for use on Cray series computers and requires approximately 5Mb memory. The program is fully vectorized. The tape includes variations for the COS and UNICOS operating systems. Also included is a sample routine for CONVEX computers to emulate Cray system time calls, which should be easy to modify for other machines as well. The standard distribution media for this version is a 9-track 1600 BPI ASCII Card Image format magnetic tape. The Cray version was developed in 1987. The IBM ES/3090 version is an IBM port of the Cray version. It is written in IBM VS FORTRAN and has the capability of executing in both vector and parallel modes on the MVS/XA operating system and in vector mode on the VM/XA operating system. Various options of the IBM VS FORTRAN compiler provide new features for the ES/3090 version, including 64-bit arithmetic and up to 2 GB of virtual addressability. The IBM ES/3090 version is available only as a 9-track, 1600 BPI IBM IEBCOPY format magnetic tape. The IBM ES/3090 version was developed in 1989. The DEC RISC ULTRIX version is a DEC port of the Cray version. It is written in FORTRAN 77 for RISC-based Digital Equipment platforms. The memory requirement is approximately 7Mb of main memory. It is available in UNIX tar format on TK50 tape cartridge. The port to DEC RISC ULTRIX was done in 1990. COS and UNICOS are trademarks and Cray is a registered trademark of Cray Research, Inc. IBM, ES/3090, VS FORTRAN, MVS/XA, and VM/XA are registered trademarks of International Business Machines. DEC and ULTRIX are registered trademarks of Digital Equipment Corporation.
    Keywords: AERODYNAMICS
    Type: COS-10029
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  • 62
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    Publication Date: 2011-08-24
    Description: Panel method computer programs are software tools of moderate cost used for solving a wide range of engineering problems. The panel code PMARC_12 (Panel Method Ames Research Center, version 12) can compute the potential flow field around complex three-dimensional bodies such as complete aircraft models. PMARC_12 is a well-documented, highly structured code with an open architecture that facilitates modifications and the addition of new features. Adjustable arrays are used throughout the code, with dimensioning controlled by a set of parameter statements contained in an include file; thus, the size of the code (i.e. the number of panels that it can handle) can be changed very quickly. This allows the user to tailor PMARC_12 to specific problems and computer hardware constraints. In addition, PMARC_12 can be configured (through one of the parameter statements in the include file) so that the code's iterative matrix solver is run entirely in RAM, rather than reading a large matrix from disk at each iteration. This significantly increases the execution speed of the code, but it requires a large amount of RAM memory. PMARC_12 contains several advanced features, including internal flow modeling, a time-stepping wake model for simulating either steady or unsteady (including oscillatory) motions, a Trefftz plane induced drag computation, off-body and on-body streamline computations, and computation of boundary layer parameters using a two-dimensional integral boundary layer method along surface streamlines. In a panel method, the surface of the body over which the flow field is to be computed is represented by a set of panels. Singularities are distributed on the panels to perturb the flow field around the body surfaces. PMARC_12 uses constant strength source and doublet distributions over each panel, thus making it a low order panel method. Higher order panel methods allow the singularity strength to vary linearly or quadratically across each panel. Experience has shown that low order panel methods can provide nearly the same accuracy as higher order methods over a wide range of cases with significantly reduced computation times; hence, the low order formulation was adopted for PMARC_12. The flow problem is solved by modeling the body as a closed surface dividing space into two regions: the region external to the surface in which an unknown velocity potential exists representing the flow field of interest, and the region internal to the surface in which a known velocity potential (representing a fictitious flow) is prescribed as a boundary condition. Both velocity potentials are required to satisfy Laplace's equation. A surface integral equation for the unknown potential external to the surface can be written by applying Green's Theorem to the external region. Using the internal potential and zero flow through the surface as boundary conditions, the unknown potential external to the surface can be solved for. When the internal flow option, which allows the analysis of closed ducts, wind tunnels, and similar internal flow problems, is selected, the geometry is modeled such that the flow field of interest is inside the geometry and the fictitious flow is outside the geometry. Items such as wings, struts, or aircraft models can be included in the internal flow problem. The time-stepping wake model gives PMARC_12 the ability to model both steady and unsteady flow problems. The wake is convected downstream from the wake-separation line by the local velocity field. With each time step, a new row of wake panels is added to the wake at the wake-separation line. Time stepping can start from time t=0 (no initial wake) or from time t=t0 (an initial wake is specified). A wide range of motions can be prescribed, including constant rates of translation, constant rate of rotation about an arbitrary axis, oscillatory translation, and oscillatory rotation about any of the three coordinate axes. Investigators interested in a visual representation of the phenomenon they are studying with PMARC_12 may want to consider obtaining the program GVS (ARC-13361), the General Visualization System. GVS is a Silicon Graphics IRIS program which was created for the purpose of supporting the scientific visualization needs of PMARC_12. GVS is available separately from COSMIC. PMARC_12 is written in standard FORTRAN 77, with the exception of the NAMELIST extension used for input. This makes the code fairly machine independent. A compiler which supports the NAMELIST extension is required. The amount of free disk space and RAM memory required for PMARC_12 will vary depending on how the code is dimensioned using the parameter statements in the include file. The recommended minimum requirements are 20Mb of free disk space and 4Mb of RAM. PMARC_12 has been successfully implemented on a Macintosh II running System 6.0.7 or 7.0 (using MPW/Language Systems Fortran 3.0), a Sun SLC running SunOS 4.1.1, an HP 720 running HP-UX 8.07, an SGI IRIS running IRIX 4.0 (it will not run under IRIX 3.x.x without modifications), an IBM RS/6000 running AIX, a DECstation 3100 running ULTRIX, and a CRAY-YMP running UNICOS 6.0 or later. Due to its memory requirements, this program does not readily lend itself to implementation on MS-DOS based machines. The standard distribution medium for PMARC_12 is a set of three 3.5 inch 800K Macintosh format diskettes and one 3.5 inch 1.44Mb Macintosh format diskette which contains an electronic copy of the documentation in MS Word 5.0 format for the Macintosh. Alternate distribution media and formats are available upon request, but these will not include the electronic version of the document. No executables are included on the distribution media. This program is an update to PMARC version 11, which was released in 1989. PMARC_12 was released in 1993. It is available only for use by United States citizens.
    Keywords: AERODYNAMICS
    Type: ARC-13362
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  • 63
    Publication Date: 2011-08-24
    Description: This program determines the supersonic flowfield surrounding three-dimensional wing-body configurations of a delta wing. It was designed to provide the numerical computation of three dimensional inviscid, flowfields of either perfect or real gases about supersonic or hypersonic airplanes. The governing equations in conservation law form are solved by a finite difference method using a second order noncentered algorithm between the body and the outermost shock wave, which is treated as a sharp discontinuity. Secondary shocks which form between these boundaries are captured automatically. The flowfield between the body and outermost shock is treated in a shock capturing fashion and therefore allows for the correct formation of secondary internal shocks . The program operates in batch mode, is in CDC update format, has been implemented on the CDC 7600, and requires more than 140K (octal) word locations.
    Keywords: AERODYNAMICS
    Type: ARC-11015
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  • 64
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    Publication Date: 2011-08-24
    Description: This theoretical aerodynamics program, TAD, was developed to predict the aerodynamic characteristics of vehicles with sounding rocket configurations. These slender, axisymmetric finned vehicle configurations have a wide range of aeronautical applications from rockets to high speed armament. Over a given range of Mach numbers, TAD will compute the normal force coefficient derivative, the center-of-pressure, the roll forcing moment coefficient derivative, the roll damping moment coefficient derivative, and the pitch damping moment coefficient derivative of a sounding rocket configured vehicle. The vehicle may consist of a sharp pointed nose of cone or tangent ogive shape, up to nine other body divisions of conical shoulder, conical boattail, or circular cylinder shape, and fins of trapezoid planform shape with constant cross section and either three or four fins per fin set. The characteristics computed by TAD have been shown to be accurate to within ten percent of experimental data in the supersonic region. The TAD program calculates the characteristics of separate portions of the vehicle, calculates the interference between separate portions of the vehicle, and then combines the results to form a total vehicle solution. Also, TAD can be used to calculate the characteristics of the body or fins separately as an aid in the design process. Input to the TAD program consists of simple descriptions of the body and fin geometries and the Mach range of interest. Output includes the aerodynamic characteristics of the total vehicle, or user-selected portions, at specified points over the mach range. The TAD program is written in FORTRAN IV for batch execution and has been implemented on an IBM 360 computer with a central memory requirement of approximately 123K of 8 bit bytes. The TAD program was originally developed in 1967 and last updated in 1972.
    Keywords: AERODYNAMICS
    Type: GSC-12680
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  • 65
    facet.materialart.
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: This program, which is called 'AOFA', determines the complete viscous and inviscid flow around a body of revolution at a given angle of attack and traveling at supersonic speeds. The viscous calculations from this program agree with experimental values for surface and pitot pressures and with surface heating rates. At high speeds, lee-side flows are important because the local heating is difficult to correlate and because the shed vortices can interact with vehicle components such as a canopy or a vertical tail. This program should find application in the design analysis of any high speed vehicle. Lee-side flows are difficult to calculate because thin-boundary-layer theory is not applicable and the concept of matching inviscid and viscous flow is questionable. This program uses the parabolic approximation to the compressible Navier-Stokes equations and solves for the complete inviscid and viscous regions of flow, including the pressure. The parabolic approximation results from the assumption that the stress derivatives in the streamwise direction are small in comparison with derivatives in the normal and circumferential directions. This assumption permits the equation to be solved by an implicit finite difference marching technique which proceeds downstream from the initial data point, provided the inviscid portion of flow is supersonic. The viscous cross-flow separation is also determined as part of the solution. To use this method it is necessary to first determine an initial data point in a region where the inviscid portion of the flow is supersonic. Input to this program consists of two parts. Problem description is conveyed to the program by namelist input. Initial data is acquired by the program as formatted data. Because of the large amount of run time this program can consume the program includes a restart capability. Output is in printed format and magnetic tape for further processing. This program is written in FORTRAN IV and has been implemented on a CDC 7600 with a central memory requirement of approximately 35K (octal) of 60 bit words.
    Keywords: AERODYNAMICS
    Type: ARC-11087
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  • 66
    Publication Date: 2011-08-24
    Description: The Comprehensive Analytical Model of Rotorcraft Aerodynamics, CAMRAD, program is designed to calculate rotor performance, loads, and noise; helicopter vibration and gust response; flight dynamics and handling qualities; and system aeroelastic stability. The analysis is a consistent combination of structural, inertial, and aerodynamic models applicable to a wide range of problems and a wide class of vehicles. The CAMRAD analysis can be applied to articulated, hingeless, gimballed, and teetering rotors with an arbitrary number of blades. The rotor degrees of freedom included are blade/flap bending, rigid pitch and elastic torsion, and optionally gimbal or teeter motion. General two-rotor aircrafts can be modeled. Single main-rotor and tandem helicopter and sideby-side tilting proprotor aircraft configurations can be considered. The case of a rotor or helicopter in a wind tunnel can also be modeled. The aircraft degrees of freedom included are the six rigid body motion, elastic airframe motions, and the rotor/engine speed perturbations. CAMRAD calculates the load and motion of helicopters and airframes in two stages. First the trim solution is obtained; then the flutter, flight dynamics, and/or transient behavior can be calculated. The trim operating conditions considered include level flight, steady climb or descent, and steady turns. The analysis of the rotor includes nonlinear inertial and aerodynamic models, applicable to large blade angles and a high inflow ratio, The rotor aerodynamic model is based on two-dimensional steady airfoil characteristics with corrections for three-dimensional and unsteady flow effects, including a dynamic stall model. In the flutter analysis, the matrices are constructed that describe the linear differential equations of motion, and the equations are analyzed. In the flight dynamics analysis, the stability derivatives are calculated and the matrices are constructed that describe the linear differential equations of motion. These equations are analyzed. In the transient analysis, the rigid body equations of motion are numerically integrated, for a prescribed transient gust or control input. The CAMRAD program product is available by license for a period of ten years to domestic U.S. licensees. The licensed program product includes the CAMRAD source code, command procedures, sample applications, and one set of supporting documentation. Copies of the documentation may be purchased separately at the price indicated below. CAMRAD is written in FORTRAN 77 for the DEC VAX under VMS 4.6 with a recommended core memory of 4.04 megabytes. The DISSPLA package is necessary for graphical output. CAMRAD was developed in 1980.
    Keywords: AERODYNAMICS
    Type: ARC-12337
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  • 67
    Publication Date: 2011-08-24
    Description: ARC2D is a computational fluid dynamics program developed at the NASA Ames Research Center specifically for airfoil computations. The program uses implicit finite-difference techniques to solve two-dimensional Euler equations and thin layer Navier-Stokes equations. It is based on the Beam and Warming implicit approximate factorization algorithm in generalized coordinates. The methods are either time accurate or accelerated non-time accurate steady state schemes. The evolution of the solution through time is physically realistic; good solution accuracy is dependent on mesh spacing and boundary conditions. The mathematical development of ARC2D begins with the strong conservation law form of the two-dimensional Navier-Stokes equations in Cartesian coordinates, which admits shock capturing. The Navier-Stokes equations can be transformed from Cartesian coordinates to generalized curvilinear coordinates in a manner that permits one computational code to serve a wide variety of physical geometries and grid systems. ARC2D includes an algebraic mixing length model to approximate the effect of turbulence. In cases of high Reynolds number viscous flows, thin layer approximation can be applied. ARC2D allows for a variety of solutions to stability boundaries, such as those encountered in flows with shocks. The user has considerable flexibility in assigning geometry and developing grid patterns, as well as in assigning boundary conditions. However, the ARC2D model is most appropriate for attached and mildly separated boundary layers; no attempt is made to model wake regions and widely separated flows. The techniques have been successfully used for a variety of inviscid and viscous flowfield calculations. The Cray version of ARC2D is written in FORTRAN 77 for use on Cray series computers and requires approximately 5Mb memory. The program is fully vectorized. The tape includes variations for the COS and UNICOS operating systems. Also included is a sample routine for CONVEX computers to emulate Cray system time calls, which should be easy to modify for other machines as well. The standard distribution media for this version is a 9-track 1600 BPI ASCII Card Image format magnetic tape. The Cray version was developed in 1987. The IBM ES/3090 version is an IBM port of the Cray version. It is written in IBM VS FORTRAN and has the capability of executing in both vector and parallel modes on the MVS/XA operating system and in vector mode on the VM/XA operating system. Various options of the IBM VS FORTRAN compiler provide new features for the ES/3090 version, including 64-bit arithmetic and up to 2 GB of virtual addressability. The IBM ES/3090 version is available only as a 9-track, 1600 BPI IBM IEBCOPY format magnetic tape. The IBM ES/3090 version was developed in 1989. The DEC RISC ULTRIX version is a DEC port of the Cray version. It is written in FORTRAN 77 for RISC-based Digital Equipment platforms. The memory requirement is approximately 7Mb of main memory. It is available in UNIX tar format on TK50 tape cartridge. The port to DEC RISC ULTRIX was done in 1990. COS and UNICOS are trademarks and Cray is a registered trademark of Cray Research, Inc. IBM, ES/3090, VS FORTRAN, MVS/XA, and VM/XA are registered trademarks of International Business Machines. DEC and ULTRIX are registered trademarks of Digital Equipment Corporation.
    Keywords: AERODYNAMICS
    Type: ARC-12112
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  • 68
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    Publication Date: 2011-08-24
    Description: Panel methods are moderate cost tools for solving a wide range of engineering problems. PMARC (Panel Method Ames Research Center) is a potential flow panel code that numerically predicts flow fields around complex three-dimensional geometries. PMARC's predecessor was a panel code named VSAERO which was developed for NASA by Analytical Methods, Inc. PMARC is a new program with many additional subroutines and a well-documented code suitable for powered-lift aerodynamic predictions. The program's open architecture facilitates modifications or additions of new features. Another improvement is the adjustable size code which allows for an optimum match between the computer hardware available to the user and the size of the problem being solved. PMARC can be resized (the maximum number of panels can be changed) in a matter of minutes. Several other state-of-the-art PMARC features include internal flow modeling for ducts and wind tunnel test sections, simple jet plume modeling essential for the analysis and design of powered-lift aircraft, and a time-stepping wake model which allows the study of both steady and unsteady motions. PMARC is a low-order panel method, which means the singularities are distributed with constant strength over each panel. In many cases low-order methods can provide nearly the same accuracy as higher order methods (where the singularities are allowed to vary linearly or quadratically over each panel). Low-order methods have the advantage of a shorter computation time and do not require exact matching between panels. The flow problem is solved by assuming that the body is at rest in a moving flow field. The body is modeled as a closed surface which divides space into two regions -- one region contains the flow field of interest and the other contains a fictitious flow. External flow problems, such as a wing in a uniform stream, have the external region as the flow field of interest and the internal flow as the fictitious flow. This arrangement is reversed for internal flow problems where the internal region contains the flow field of interest and the external flow field is fictitious. In either case it is assumed that the velocity potentials in both regions satisfy Laplace's equation. PMARC has extensive geometry modeling capabilities for handling complex, three-dimensional surfaces. As with all panel methods, the geometry must be modeled by a set of panels. For convenience, the geometry is usually subdivided into several pieces and modeled with sets of panels called patches. A patch may be folded over on itself so that opposing sides of the patch form a common line. For example, wings are normally modeled with a folded patch to form the trailing edge of the wing. PMARC also has the capability to automatically generate a closing tip patch. In the case of a wing, a tip patch could be generated to close off the wing's third side. PMARC has a simple jet model for simulating a jet plume in a crossflow. The jet plume shape, trajectory, and entrainment velocities are computed using the Adler/Baron jet in crossflow code. This information is then passed back to PMARC. The wake model in PMARC is a time-stepping wake model. The wake is convected downstream from the wake separation line by the local velocity flowfield. With each time step, a new row of wake panels is added to the wake at the wake separation line. PMARC also allows an initial wake to be specified if desired, or, as a third option, no wakes need be modeled. The effective presentation of results for aerodynamics problems requires the generation of report-quality graphics. PMAPP (ARC-12751), the Panel Method Aerodynamic Plotting Program, (Sterling Software), was written for scientists at NASA's Ames Research Center to plot the aerodynamic analysis results (flow data) from PMARC. PMAPP is an interactive, color-capable graphics program for the DEC VAX or MicroVAX running VMS. It was designed to work with a variety of terminal types and hardcopy devices. PMAPP is available separately from COSMIC. PMARC was written in standard FORTRAN77 using adjustable size arrays throughout the code. Redimensioning PMARC will change the amount of disk space and memory the code requires to be able to run; however, due to its memory requirements, this program does not readily lend itself to implementation on MS-DOS based machines. The program was implemented on an Apple Macintosh (using 2.5 MB of memory) and tested on a VAX/VMS computer. The program is available on a 3.5 inch Macintosh format diskette (standard media) or in VAX BACKUP format on TK50 tape cartridge or 9-track magnetic tape. PMARC was developed in 1989.
    Keywords: AERODYNAMICS
    Type: ARC-12642
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  • 69
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    Publication Date: 2011-08-24
    Description: The Transonic Airfoil analysis computer code, TAIR, was developed to employ a fast, fully implicit algorithm to solve the conservative full-potential equation for the steady transonic flow field about an arbitrary airfoil immersed in a subsonic free stream. The full-potential formulation is considered exact under the assumptions of irrotational, isentropic, and inviscid flow. These assumptions are valid for a wide range of practical transonic flows typical of modern aircraft cruise conditions. The primary features of TAIR include: a new fully implicit iteration scheme which is typically many times faster than classical successive line overrelaxation algorithms; a new, reliable artifical density spatial differencing scheme treating the conservative form of the full-potential equation; and a numerical mapping procedure capable of generating curvilinear, body-fitted finite-difference grids about arbitrary airfoil geometries. Three aspects emphasized during the development of the TAIR code were reliability, simplicity, and speed. The reliability of TAIR comes from two sources: the new algorithm employed and the implementation of effective convergence monitoring logic. TAIR achieves ease of use by employing a "default mode" that greatly simplifies code operation, especially by inexperienced users, and many useful options including: several airfoil-geometry input options, flexible user controls over program output, and a multiple solution capability. The speed of the TAIR code is attributed to the new algorithm and the manner in which it has been implemented. Input to the TAIR program consists of airfoil coordinates, aerodynamic and flow-field convergence parameters, and geometric and grid convergence parameters. The airfoil coordinates for many airfoil shapes can be generated in TAIR from just a few input parameters. Most of the other input parameters have default values which allow the user to run an analysis in the default mode by specifing only a few input parameters. Output from TAIR may include aerodynamic coefficients, the airfoil surface solution, convergence histories, and printer plots of Mach number and density contour maps. The TAIR program is written in FORTRAN IV for batch execution and has been implemented on a CDC 7600 computer with a central memory requirement of approximately 155K (octal) of 60 bit words. The TAIR program was developed in 1981.
    Keywords: AERODYNAMICS
    Type: ARC-11436
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  • 70
    Publication Date: 2011-08-24
    Description: The TAWFIVE program calculates transonic flow over a transport-type wing and fuselage. Although more complex Euler and Navier-Stokes methods are available, TAWFIVE combines a multi-grid acceleration technique in the iterative solution of the potential equation with the use of integral-form boundary-layer equations to provide a computationally efficient and sufficiently accurate design tool. TAWFIVE simplifies the solution process by breaking the problem into a loosely coupled set of modified equations. The inviscid method, using standard inviscid equations (nonlinear full potential), is valid in the "outer" region away from the wing, whereas the boundary-layer equations are valid in the thin region near the solid surface of the wing. The two types of equations are coupled by a technique of modifying surface boundary conditions for the inviscid equations. This interaction process starts with a solution of the outer flow field. Pressures are computed at the wing surface and are used to calculate the boundary layer. The boundary-layer and wake properties are then computed using a three-dimensional integral method, and the computed displacement thickness is added to the surface of the "hard" geometry. This new displaced wing surface is then regridded and the inviscid flowfield is recomputed. New values of the inviscid pressures are then used by the boundary-layer method to predict a new displacement thickness distribution. An under-relaxed update of the previously predicted displacement thickness is then made to obtain a new displacement thickness correction that is added to the "hard" geometry. These global iterations are continued until suitable convergence is obtained. Input to TAWFIVE is limited to geometric definition of the configuration, free-stream flow quantities, and iteration control parameters. The geometric input consists of the definition of a series of airfoil sections to define the wing and a series of fuselage cross sections to model the fuselage. High-aspect-ratio wings are modeled more accurately than low-aspect-ratio wings since no special provisions are made to accurately model the wing-fuselage juncture or the wingtip region. The user can specify the solution either in terms of lift or in terms of angle of attack. TAWFIVE can produce tabular output and input files for PLOT3D (COSMIC program number ARC-12779). TAWFIVE is written in FORTRAN 77 for CRAY series computers running UNICOS. The main memory requirement is 2.7Mb for execution. This program is available on a 9-track 1600 BPI UNIX tar format magnetic tape. TAWFIVE was under development from 1979 to 1989 and first released by COSMIC in 1991. CRAY and UNICOS are registered trademarks of Cray Research, Inc.
    Keywords: AERODYNAMICS
    Type: LAR-14722
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  • 71
    Publication Date: 2011-08-24
    Description: A summary is presented of vortex control applications and current techniques for the control of longitudinal vortices produced by bodies, leading edges, tips and intersections. Vortex control has up till now been performed by many approaches in an empirical fashion, assisted by the essentially inviscid nature of much of longitudinal vortex behavior. Attention is given to Reynolds number sensitivities, vortex breakdown and interactions, vortex control on highly swept wings, and vortex control in juncture flows.
    Keywords: AERODYNAMICS
    Type: Aeronautical Journal (ISSN 0001-9240); 96; 958; p. 293-312.
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  • 72
    Publication Date: 2011-08-24
    Description: The flow-field within an axial flow turbomachine, such as a turbine or compressor, is extremely complex because of three-dimensional features such as hub-corner stall, tip-leakage flows, and airfoil wakes. These flow features interact with each other and with rotor and stator airfoils inducing time-varying forces on the airfoils. These complicated rotor-stator interactions must be understood in order to design turbomachines that are light and compact as well as reliable and efficient. Two codes, STAGE-2 and STAGE-3, have been developed to compute these unsteady rotor-stator interaction flows in multistage turbomachines. An implicit, thin-layer Euler/Navier-Stokes zonal algorithm is used to compute the unsteady flow-field within both turbine and compressor configurations. Results include surface pressures and wake profiles for two-dimensional turbine and compressor configurations and surface pressures for a three-dimensional single-stage turbine configuration. The results compare well with experimental data and other unsteady computations.
    Keywords: AERODYNAMICS
    Type: Computing Systems in Engineering (ISSN 0956-0521); 3; 1-4; p. 231-240.
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  • 73
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    Publication Date: 2011-08-24
    Description: Jet noise and jet-induced structural loads have become key issues in the design of commercial and military aircraft. Computational Fluid Dynamics (CFD) can be of use in predicting the underlying jet shear-layer instabilities and, in conjunction with classical acoustic theory, jet noise. The computational issues involved in the resolution of high Reynolds number unsteady jet flows are addressed in this paper. Once these jet flows can be accurately resolved, it should be possible to use acoustic theory to extract, for example, the far-field jet noise. An assessment of future work and computational resources required for directly computing far-field jet noise is also presented.
    Keywords: AERODYNAMICS
    Type: Computing Systems in Engineering (ISSN 0956-0521); 3; 1-4; p. 169-179.
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  • 74
    facet.materialart.
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: This computer program is designed to calculate the flow fields in two-dimensional and three-dimensional axisymmetric supersonic inlets. The method of characteristics is used to compute arrays of points in the flow field. At each point the total pressure, local Mach number, local flow angle, and static pressure are calculated. This program can be used to design and analyze supersonic inlets by determining the surface compression rates and throat flow properties. The program employs the method of characteristics for a perfect gas. The basic equation used in the program is the compatibility equation which relates the change in stream angle to the change in entropy and the change in velocity. In order to facilitate the computation, the flow field behind the bow shock wave is broken into regions bounded by shock waves. In each region successive rays are computed from a surface to a shock wave until the shock wave intersects a surface or falls outside the cowl lip. As soon as the intersection occurs a new region is started and the previous region continued only in the area in which it is needed, thus eliminating unnecessary calculations. The maximum number of regions possible in the program is ten, which allows for the simultaneous calculations of up to nine shock waves. Input to this program consists of surface contours, free-stream Mach number, and various calculation control parameters. Output consists of printed and/or plotted results. For plotted results an SC-4020 or similar plotting device is required. This program is written in FORTRAN IV to be executed in the batch mode and has been implemented on a CDC 7600 with a central memory requirement of approximately 27k (octal) of 60 bit words.
    Keywords: AERODYNAMICS
    Type: ARC-11098
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  • 75
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: This program was developed to predict turbine stage performance taking into account the effects of complex passage geometries. The method uses a quasi-3D inviscid-flow analysis iteratively coupled to calculated losses so that changes in losses result in changes in the flow distribution. In this manner the effects of both the geometry on the flow distribution and the flow distribution on losses are accounted for. The flow may be subsonic or shock-free transonic. The blade row may be fixed or rotating, and the blades may be twisted and leaned. This program has been applied to axial and radial turbines, and is helpful in the analysis of mixed flow machines. This program is a combination of the flow analysis programs MERIDL and TSONIC coupled to the boundary layer program BLAYER. The subsonic flow solution is obtained by a finite difference, stream function analysis. Transonic blade-to-blade solutions are obtained using information from the finite difference, stream function solution with a reduced flow factor. Upstream and downstream flow variables may vary from hub to shroud and provision is made to correct for loss of stagnation pressure. Boundary layer analyses are made to determine profile and end-wall friction losses. Empirical loss models are used to account for incidence, secondary flow, disc windage, and clearance losses. The total losses are then used to calculate stator, rotor, and stage efficiency. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370/3033 under TSS with a central memory requirement of approximately 4.5 Megs of 8 bit bytes. This program was developed in 1985.
    Keywords: AERODYNAMICS
    Type: LEW-14218
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  • 76
    Publication Date: 2011-08-24
    Description: Turbomachinery components are often connected by ducts, which are usually annular. The configurations and aerodynamic characteristics of these ducts are crucial to the optimum performance of the turbomachinery blade rows. The ANDUCT computer program was developed to calculate the velocity distribution along an arbitrary line between the inner and outer walls of an annular duct with axisymmetric swirling flow. Although other programs are available for duct analysis, the use of the velocity gradient method makes the ANDUCT program fast and convenient while requiring only modest computer resources. A fast and easy method of analyzing the flow through a duct with axisymmetric flow is the velocity gradient method, also known as the stream filament or streamline curvature method. This method has been used extensively for blade passages but has not been widely used for ducts, except for the radial equilibrium equation. In ANDUCT, a velocity gradient equation derived from the momentum equation is used to determine the velocity variation along an arbitrary straight line between the inner and outer wall of an annular duct. The velocity gradient equation is used with an assumed variation of meridional streamline curvature. Upstream flow conditions may vary between the inner and outer walls, and an assumed total pressure distribution may be specified. ANDUCT works best for well-guided passages and where the curvature of the walls is small as compared to the width of the passage. The ANDUCT program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 60K of 8 bit bytes. The ANDUCT program was developed in 1982.
    Keywords: AERODYNAMICS
    Type: LEW-14000
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  • 77
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: The Panel Code for Planar Cascades was developed as an aid for the designer of turbomachinery blade rows. The effective design of turbomachinery blade rows relies on the use of computer codes to model the flow on blade-to-blade surfaces. Most of the currently used codes model the flow as inviscid, irrotational, and compressible with solutions being obtained by finite difference or finite element numerical techniques. While these codes can yield very accurate solutions, they usually require an experienced user to manipulate input data and control parameters. Also, they often limit a designer in the types of blade geometries, cascade configurations, and flow conditions that can be considered. The Panel Code for Planar Cascades accelerates the design process and gives the designer more freedom in developing blade shapes by offering a simple blade-to-blade flow code. Panel, or integral equation, solution techniques have been used for several years by external aerodynamicists who have developed and refined them into a primary design tool of the aircraft industry. The Panel Code for Planar Cascades adapts these same techniques to provide a versatile, stable, and efficient calculation scheme for internal flow. The code calculates the compressible, inviscid, irrotational flow through a planar cascade of arbitrary blade shapes. Since the panel solution technique is for incompressible flow, a compressibility correction is introduced to account for compressible flow effects. The analysis is limited to flow conditions in the subsonic and shock-free transonic range. Input to the code consists of inlet flow conditions, blade geometry data, and simple control parameters. Output includes flow parameters at selected control points. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 590K of 8 bit bytes. This program was developed in 1982.
    Keywords: AERODYNAMICS
    Type: LEW-13862
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  • 78
    Publication Date: 2011-08-24
    Description: An exact, full-potential-equation model for the steady, irrotational, homoentropic, and homoenergetic flow of a compressible, inviscid fluid through a two-dimensional planar cascade together with its appropriate boundary conditions has been derived. The CAS2D computer program numerically solves an artificially time-dependent form of the actual full-potential-equation, providing a nonrotating blade-to-blade, steady, potential transonic cascade flow analysis code. Comparisons of results with test data and theoretical solutions indicate very good agreement. In CAS2D, the governing equation is discretized by using type-dependent, rotated finite differencing and the finite area technique. The flow field is discretized by providing a boundary-fitted, nonuniform computational mesh. This mesh is generated by using a sequence of conformal mapping, nonorthogonal coordinate stretching, and local, isoparametric, bilinear mapping functions. The discretized form of the full-potential equation is solved iteratively by using successive line over relaxation. Possible isentropic shocks are captured by the explicit addition of an artificial viscosity in a conservative form. In addition, a four-level, consecutive, mesh refinement feature makes CAS2D a reliable and fast algorithm for the analysis of transonic, two-dimensional cascade flows. The results from CAS2D are not directly applicable to three-dimensional, potential, rotating flows through a cascade of blades because CAS2D does not consider the effects of the Coriolis force that would be present in the three-dimensional case. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 200K of 8 bit bytes. The CAS2D program was developed in 1980.
    Keywords: AERODYNAMICS
    Type: LEW-13854
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  • 79
    Publication Date: 2011-08-24
    Description: A computer program, QSONIC, has been developed for calculating the full potential, transonic quasi-three-dimensional flow through a rotating turbomachinery blade row. The need for lighter, more efficient turbomachinery components has led to the consideration of machines with fewer stages, each with blades capable of higher speeds and higher loading. As speeds increase, the numerical problems inherent in the transonic regime have to be resolved. These problems include the calculation of imbedded shock discontinuities and the dual nature of the governing equations, which are elliptic in the subcritical flow regions but become hyperbolic for supersonic zones. QSONIC provides the flow analyst with a fast and reliable means of obtaining the transonic potential flow distribution on a blade-to-blade stream surface of a stationary or rotating turbomachine blade row. QSONIC combines several promising transonic analysis techniques. The full potential equation in conservative form is discretized at each point on a body-fitted period mesh. A mass balance is calculated through the finite volume surrounding each point. Each local volume is corrected in the third dimension for any change in stream-tube thickness along the stream tube. The nonlinear equations for all volumes are of mixed type (elliptic or hyperbolic) depending on the local Mach number. The final result is a block-tridiagonal matrix formulation involving potential corrections at each grid point as the unknowns. The residual of each system of equations is solved along each grid line. At points where the Mach number exceeds unity, the density at the forward (sweeping) edge of the volume is replaced by an artificial density. This method calculates the flow field about a cascade of arbitrary two-dimensional airfoils. Three-dimensional flow is approximated in a turbomachinery blade row by correcting for stream-tube convergence and radius change in the through flow direction. Several significant assumptions were made in developing the QSONIC program, including: (1) the flow is inviscid and adiabatic, (2) the flow relative to the blade is steady, (3) the fluid is a perfect gas with constant specific heat, (4) the flow is isentropic and any discontinuities (shocks) are weak enough to be approximated as isentropic jumps, (5) there is no velocity component normal to the stream surface, and (6) the flow relative to a fixed frame in space (absolute velocity) is completely irrotational. These assumptions place some limitations on the application of QSONIC. Sharp leading edges at high incidence and high-Mach-number turbine blade trailing edges with substantial deviation will both cause large velocity peaks on the blade. In addition, the program may have difficulty converging if the passage is nearly choked. Input to QSONIC consists of case control parameters, a geometry description, upstream boundary conditions, and a rotor description. Output includes solution scheme parameters and flow field parameters. A data file is also output which contains data on the solution mesh, surface Mach numbers, surface static pressures, isomachs, and the velocity vector field. This data may be used for further processing or for plotting. The QSONIC is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 500K of 8 bit bytes. QSONIC was developed in 1982.
    Keywords: AERODYNAMICS
    Type: LEW-13832
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  • 80
    Publication Date: 2011-08-24
    Description: This computer program, WIND, was developed to numerically solve the exact, full-potential equation for three-dimensional, steady, inviscid flow through an isolated wind turbine rotor. The program automatically generates a three-dimensional, boundary-conforming grid and iteratively solves the full-potential equation while fully accounting for both the rotating and Coriolis effects. WIND is capable of numerically analyzing the flow field about a given blade shape of the horizontal-axis type wind turbine. The rotor hub is assumed representable by a doubly infinite circular cylinder. An arbitrary number of blades may be attached to the hub and these blades may have arbitrary spanwise distributions of taper and of the twist, sweep, and dihedral angles. An arbitrary number of different airfoil section shapes may be used along the span as long as the spanwise variation of all the geometeric parameters is reasonably smooth. The numerical techniques employed in WIND involve rotated, type-dependent finite differencing, a finite volume method, artificial viscosity in conservative form, and a successive overrelaxation combined with the sequential grid refinement procedure to accelerate the iterative convergence rate. Consequently, WIND is cabable of accurately analyzing incompressible and compressible flows, including those that are locally transonic and terminated by weak shocks. Along with the three-dimensional results, WIND provides the results of the two-dimensional calculations to aid the user in locating areas of possible improvement in the aerodynamic design of the blade. Output from WIND includes the chordwise distribution of the coefficient of pressure, the Mach number, the density, and the relative velocity components at spanwise stations along the blade. In addition, the results specify local values of the lift coefficient and the tangent and axial aerodynamic force components. These are also given in integrated form expressing the total torque and the total axial force acting on the shaft. WIND can also be used to analyze the flow around isolated aircraft propellers and helicopter rotors in hover as long as the relative oncoming flow is subsonic. The WIND program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 253K of 8 bit bytes. WIND was developed in 1980.
    Keywords: AERODYNAMICS
    Type: LEW-13740
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  • 81
    Publication Date: 2011-08-24
    Description: This computer program calculates the flow field in the supersonic portion of a mixed-compression aircraft inlet at non-zero angle of attack. This approach is based on the method of characteristics for steady three-dimensional flow. The results of this program agree with those produced by the two-dimensional method of characteristics when axisymmetric flow fields are calculated. Except in regions of high viscous interaction and boundary layer removal, the results agree well with experimental data obtained for threedimensional flow fields. The flow field in a variety of axisymmetric mixed compression inlets can be calculated using this program. The bow shock wave and the internal shock wave system are calculated using a discrete shock wave fitting procedure. The internal flow field can be calculated either with or without the discrete fitting of the internal shock wave system. The influence of molecular transport can be included in the calculation of the external flow about the forebody and in the calculation of the internal flow when internal shock waves are not discretely fitted. The viscous and thermal diffussion effects are included by treating them as correction terms in the method of characteristics procedure. Dynamic viscosity is represented by Sutherland's law and thermal conductivity is represented as a quadratic function of temperature. The thermodynamic model used is that of a thermally and calorically perfect gas. The program assumes that the cowl lip is contained in a constant plane and that the centerbody contour and cowl contour are smooth and have continuous first partial derivatives. This program cannot calculate subsonic flow, the external flow field if the bow shock wave does not exist entirely around the forebody, or the internal flow field if the bow flow field is injected into the annulus. Input to the program consists of parameters to control execution, to define the geometry, and the vehicle orientation. Output consists of a list of parameters used, solution planes, and a description of the shock waves. This program is written in FORTRAN IV for batch execution and has been implemented on a CDC 6000 series machine with a central memory requirement of 110K (octal) of 60 bit words when it is overlayed. This flow analysis program was developed in 1978.
    Keywords: AERODYNAMICS
    Type: LEW-13279
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  • 82
    Publication Date: 2011-08-24
    Description: This computer program was developed for calculating the subsonic or transonic flow on the hub-shroud mid-channel stream surface of a single blade row of a turbomachine. The design and analysis of blades for compressors and turbines ideally requires methods for analyzing unsteady, three-dimensional, turbulent viscous flow through a turbomachine. Since an exact solution is impossible at present, solutions on two-dimensional surfaces are calculated to obtain a quasi-three dimensional solution. When three-dimensional effects are important, significant information can be obtained from a solution on a cross-sectional surface of the passage normal to the flow. With this program, a solution to the equations of flow on the meridional surface can be carried out. This solution is chosen when the turbomachine under consideration has significant variation in flow properties in the hubshroud direction, especially when input is needed for use in blade-to-blade calculations. The program can also perform flow calculations for annular ducts without blades. This program should prove very useful in the design and analysis of any turbomachine. This program calculates a solution for two-dimensional, adiabatic shockfree flow. The flow must be essentially subsonic, but there may be local areas of supersonic flow. To obtain the solution, this program uses both the finite difference and the quasi-orthogonal (velocity gradient) methods combined in a way that takes maximum advantage of both. The finite-difference method solves a finite-difference equation along the meridional stream surface in a very efficient manner but is limited to subsonic velocities. This approach must be used in cases where the blade aspect ratios are above one, cases where the passage is curved, and cases with low hub-tip-ratio blades. The quasi-orthogonal method solves the velocity gradient equation on the meridional surface and is used if it is necessary to extend the range of solutions into the transonic regime. In general the blade row may be fixed or rotating and the blades may be twisted and leaned. The flow may be axial, radial, or mixed. The upstream and downstream flow conditions can vary from hub to shroud with provisions made for an approximate correction for loss of stagnation pressure. Also, viscous forces are neglected along solution mesh lines running from hub to tip. The capabilities of this program include handling of nonaxial flows without restriction, annular ducts without blades, and specified streamwise loss distributions. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 360 computer with a central memory requirement of approximately 700K of 8 bit bytes. This core requirement can be reduced depending on the size of the problem and the desired solution accuracy. This program was developed in 1977.
    Keywords: AERODYNAMICS
    Type: LEW-12966
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  • 83
    Publication Date: 2011-08-24
    Description: A computer program has been developed for the design of supersonic rotor blades where losses are accounted for by correcting the ideal blade geometry for boundary layer displacement thickness. The ideal blade passage is designed by the method of characteristics and is based on establishing vortex flow within the passage. Boundary-layer parameters (displacement and momentum thicknesses) are calculated for the ideal passage, and the final blade geometry is obtained by adding the displacement thicknesses to the ideal nozzle coordinates. The boundary-layer parameters are also used to calculate the aftermixing conditions downstream of the rotor blades assuming the flow mixes to a uniform state. The computer program input consists essentially of the rotor inlet and outlet Mach numbers, upper- and lower-surface Mach numbers, inlet flow angle, specific heat ratio, and total flow conditions. The program gas properties are set up for air. Additional gases require changes to be made to the program. The computer output consists of the corrected rotor blade coordinates, the principal boundary-layer parameters, and the aftermixing conditions. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 7094. This program was developed in 1971.
    Keywords: AERODYNAMICS
    Type: LEW-11744
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  • 84
    Publication Date: 2011-08-24
    Description: This program obtains a transonic flow solution on a blade-to-blade surface between blades of a turbomachine. The flow must be essentially subsonic, but there may be locally supersonic flow. The solution is two-dimensional, isentropic, and shock free. The blades may be fixed or rotating. The flow may be axial, radial, or mixed, and there may be a change in stream-channel thickness in the through-flow direction. A loss in relative stagnation pressure may be accounted for. The program input consists of blade and stream-channel geometry, stagnation flow conditions, inlet and outlet flow angles, and blade-to-blade stream-channel weight flow. The output includes blade surface velocities, velocity magnitude and direction at all interior mesh points in the blade-to-blade passage, and streamline coordinates throughout the passage. The transonic solution is obtained by a combination of a finite-difference, stream-function solution and a velocity-gradient solution. The finite-difference solution at a reduced weight flow provides information needed to obtain a velocity-gradient solution. This program is written in FORTRAN IV for batch execution and has been implemented on the IBM 360 computer with a central memory requirement of approximately 36K of 8 bit bytes. This program was developed in 1969 and last updated in 1979.
    Keywords: AERODYNAMICS
    Type: LEW-10977
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  • 85
    Publication Date: 2011-08-24
    Description: This program is a revision of an existing program for blade-to-blade aerodynamic analysis of turbomachine blades and it is a simpler program while consistent with related programs. The analysis is for two-dimensional, subsonic, compressible (or incompressible), nonviscous flow in a circular or straight infinite cascade of blades, which may be fixed or rotating. The flow may be axial, radial, or mixed, and the stream channel thickness may change in the through-flow direction. The program input consists of blade and stream channel geometry, total flow conditions, inlet and outlet flow angles, and blade-to-blade stream channel weight flow. The output includes blade surface velocities, velocity magnitude and direction at all interior mesh points in the blade-to-blade passage, and streamline coordinates throughout the passage. This program was developed on an IBM 7094/7044 DCS.
    Keywords: AERODYNAMICS
    Type: LEW-10788
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  • 86
    Publication Date: 2011-08-24
    Description: This computer program gives the blade-to-blade solution of the two-dimensional, subsonic, compressible (or incompressible), nonviscous flow problem for a circular or straight infinite cascade of tandem or slotted turbomachine blades. The blades may be fixed or rotating. The flow may be axial, radial , or mixed. The method of solution is based on the stream function using an iterative solution of nonlinear finite-difference equations. These equations are solved using two major levels of iteration. The inner iteration consists of the solution of simultaneous linear equations by successive over-relaxation, using an estimated optimum over-relaxation factor. The outer iteration then changes the coefficients of the simultaneous equations to correct for compressibility. The program input consists of the basic blade geometry, the meridional stream channel coordinates, fluid stagnation conditions, weight flow and flow split through the slot, and inlet and outlet flow angles. The output includes blade surface velocities, velocity magnitude and direction throughout the passage, and the streamline coordinates.
    Keywords: AERODYNAMICS
    Type: LEW-10743
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  • 87
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    Publication Date: 2011-08-24
    Description: This FORTRAN IV computer program which incorporates the method of characteristics was written to assist in the design of supersonic inlets. There were two objectives: (1) to study a greater variety of supersonic inlet configurations and (2) to reduce the time required for trial-and-error procedures to arrive at optimum inlet design. The computer program was written with the intention of being able to construct a variety of inlet configurations by interchanging specific subroutines. In this manner, greater flexibility of choice was attained, and the time required to program a specific inlet configuration was greatly reduced. The second objective was accomplished by a reformulation of the boundary value problem for hyperbolic equations. By this reformulation of the boundary data, the engineering design quantities, throat Mach number and flow angle, were introduced as direct input quantities to the computer program. As a consequence of introducing the engineering parameters as input, the computer program will calculate the surface contours required to satisfy the specific throat conditions. Inviscid flow is assumed and the method used to calculate the inlet contour results in minimum distortion to the flow in the throat. This program was developed on an IBM 7094.
    Keywords: AERODYNAMICS
    Type: LEW-10868
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  • 88
    Publication Date: 2011-08-24
    Description: This program represents a subsonic aerodynamic method for determining the mean camber surface of trimmed noncoplaner planforms with minimum vortex drag. With this program, multiple surfaces can be designed together to yield a trimmed configuration with minimum induced drag at some specified lift coefficient. The method uses a vortex-lattice and overcomes previous difficulties with chord loading specification. A Trefftz plane analysis is used to determine the optimum span loading for minimum drag. The program then solves for the mean camber surface of the wing associated with this loading. Pitching-moment or root-bending-moment constraints can be employed at the design lift coefficient. Sensitivity studies of vortex-lattice arrangements have been made with this program and comparisons with other theories show generally good agreement. The program is very versatile and has been applied to isolated wings, wing-canard configurations, a tandem wing, and a wing-winglet configuration. The design problem solved with this code is essentially an optimization one. A subsonic vortex-lattice is used to determine the span load distribution(s) on bent lifting line(s) in the Trefftz plane. A Lagrange multiplier technique determines the required loading which is used to calculate the mean camber slopes, which are then integrated to yield the local elevation surface. The problem of determining the necessary circulation matrix is simplified by having the chordwise shape of the bound circulation remain unchanged across each span, though the chordwise shape may vary from one planform to another. The circulation matrix is obtained by calculating the spanwise scaling of the chordwise shapes. A chordwise summation of the lift and pitching-moment is utilized in the Trefftz plane solution on the assumption that the trailing wake does not roll up and that the general configuration has specifiable chord loading shapes. VLMD is written in FORTRAN for IBM PC series and compatible computers running MS-DOS. This program requires 360K of RAM for execution. The Ryan McFarland FORTRAN compiler and PLINK86 are required to recompile the source code; however, a sample executable is provided on the diskette. The standard distribution medium for VLMD is a 5.25 inch 360K MS-DOS format diskette. VLMD was originally developed for use on CDC 6000 series computers in 1976. It was originally ported to the IBM PC in 1986, and, after minor modifications, the IBM PC port was released in 1993.
    Keywords: AERODYNAMICS
    Type: LAR-15160
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  • 89
    Publication Date: 2011-08-24
    Description: This code was developed to aid design engineers in the selection and evaluation of aerodynamically efficient wing-canard and wing-horizontal-tail configurations that may employ simple hinged-flap systems. Rapid estimates of the longitudinal aerodynamic characteristics of conceptual airplane lifting surface arrangements are provided. The method is particularly well suited to configurations which, because of high speed flight requirements, must employ thin wings with highly swept leading edges. The code is applicable to wings with either sharp or rounded leading edges. The code provides theoretical pressure distributions over the wing, the canard or horizontal tail, and the deflected flap surfaces as well as estimates of the wing lift, drag, and pitching moments which account for attainable leading edge thrust and leading edge separation vortex forces. The wing planform information is specified by a series of leading edge and trailing edge breakpoints for a right hand wing panel. Up to 21 pairs of coordinates may be used to describe both the leading edge and the trailing edge. The code has been written to accommodate 2000 right hand panel elements, but can easily be modified to accommodate a larger or smaller number of elements depending on the capacity of the target computer platform. The code provides solutions for wing surfaces composed of all possible combinations of leading edge and trailing edge flap settings provided by the original deflection multipliers and by the flap deflection multipliers. Up to 25 pairs of leading edge and trailing edge flap deflection schedules may thus be treated simultaneously. The code also provides for an improved accounting of hinge-line singularities in determination of wing forces and moments. To determine lifting surface perturbation velocity distributions, the code provides for a maximum of 70 iterations. The program is constructed so that successive runs may be made with a given code entry. To make additional runs, it is necessary only to add an identification record and the namelist data that are to be changed from the previous run. This code was originally developed in 1989 in FORTRAN V on a CDC 6000 computer system, and was later ported to an MS-DOS environment. Both versions are available from COSMIC. There are only a few differences between the PC version (LAR-14458) and CDC version (LAR-14178) of AERO2S distributed by COSMIC. The CDC version has one main source code file while the PC version has two files which are easier to edit and compile on a PC. The PC version does not require a FORTRAN compiler which supports NAMELIST because a special INPUT subroutine has been added. The CDC version includes two MODIFY decks which can be used to improve the code and prevent the possibility of some infrequently occurring errors while PC-version users will have to make these code changes manually. The PC version includes an executable which was generated with the Ryan McFarland/FORTRAN compiler and requires 253K RAM and an 80x87 math co-processor. Using this executable, the sample case requires about four hours to execute on an 8MHz AT-class microcomputer with a co-processor. The source code conforms to the FORTRAN 77 standard except that it uses variables longer than six characters. With two minor modifications, the PC version should be portable to any computer with a FORTRAN compiler and sufficient memory. The CDC version of AERO2S is available in CDC NOS Internal format on a 9-track 1600 BPI magnetic tape. The PC version is available on a set of two 5.25 inch 360K MS-DOS format diskettes. IBM AT is a registered trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. CDC is a registered trademark of Control Data Corporation. NOS is a trademark of Control Data Corporation.
    Keywords: AERODYNAMICS
    Type: LAR-14178
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  • 90
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    Publication Date: 2011-08-24
    Description: This program provides a wing design algorithm based on modified linear theory which takes into account the effects of attainable leading-edge thrust. A primary objective of the WINGDES2 approach is the generation of a camber surface as mild as possible to produce drag levels comparable to those attainable with full theoretical leading-edge thrust. WINGDES2 provides both an analysis and a design capability and is applicable to both subsonic and supersonic flow. The optimization can be carried out for designated wing portions such as leading and trailing edge areas for the design of mission-adaptive surfaces, or for an entire planform such as a supersonic transport wing. This program replaces an earlier wing design code, LAR-13315, designated WINGDES. WINGDES2 incorporates modifications to improve numerical accuracy and provides additional capabilities. A means of accounting for the presence of interference pressure fields from airplane components other than the wing and a direct process for selection of flap surfaces to approach the performance levels of the optimized wing surfaces are included. An increased storage capacity allows better numerical representation of those configurations that have small chord leading-edge or trailing-edge design areas. WINGDES2 determines an optimum combination of a series of candidate surfaces rather than the more commonly used candidate loadings. The objective of the design is the recovery of unrealized theoretical leading-edge thrust of the input flat surface by shaping of the design surface to create a distributed thrust and thus minimize drag. The input consists of airfoil section thickness data, leading and trailing edge planform geometry, and operational parameters such as Mach number, Reynolds number, and design lift coefficient. Output includes optimized camber surface ordinates, pressure coefficient distributions, and theoretical aerodynamic characteristics. WINGDES2 is written in FORTRAN V for batch execution and has been implemented on a CDC CYBER computer operating under NOS 2.7.1 with a central memory requirement of approximately 344K (octal) of 60 bit words. This program was developed in 1984, and last updated in 1990. CDC and CYBER are trademarks of Control Data Corporation.
    Keywords: AERODYNAMICS
    Type: LAR-13995
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  • 91
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 31; 10; p. 1744-1752.
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  • 92
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 30; 5; p. 791-793. Abridged
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  • 93
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 30; 5; p. 711-718.
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  • 94
    Publication Date: 2011-08-24
    Description: Unsteady flow behavior and load characteristics of a 2D VR-7 airfoil with and without a leading-edge slat were studied in the water tunnel of the Aeroflightdynamics Directorate, NASA Ames Research Center. Both airfoils were oscillated sinusoidally between 5 and 25 deg at Re = 200,000 to obtain the unsteady lift, drag, and pitching moment data. A fluorescent dye was released from an orifice located at the leading edge of the airfoil for the purpose of visualizing the boundary layer and wake flow. The flowfield and load predictions of an incompressible Navier-Stokes code based on a velocity-vorticity formulation were compared with the test data. The test and predictions both confirm that the slatted VR-7 airfoil delays both static and dynamic stall as compared to the VR-7 airfoil alone.
    Keywords: AERODYNAMICS
    Type: Computers & Fluids (ISSN 0045-7930); 22; 4-5; p. 529-547.
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  • 95
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: American Helicopter Society, Journal (ISSN 0002-8711); 38; 2; p. 61-67.
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  • 96
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: American Helicopter Society, Journal (ISSN 0002-8711); 38; 2; p. 53-60.
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  • 97
    Publication Date: 2011-08-24
    Keywords: AERODYNAMICS
    Type: Journal of Propulsion and Power (ISSN 0748-4658); 9; 4; p. 605-614.
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  • 98
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: The problem of the hypersonic double ellipse in rarefied flow is treated by a particle method using the collision model first described by McDonald (1988). In the approach used here, the computational overhead is reduced by using simple cubic cells. The problem of the definition of complex geometries is addressed by developing an algorithm to define the relation of a body surface to the network of cells.
    Keywords: AERODYNAMICS
    Type: In: Hypersonic flows for reentry problems. Vol. 2 (A93-42576 17-02); p. 912-923.
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  • 99
    Publication Date: 2011-08-24
    Description: Program LAURA (Langley Aerothermodynamic Upwind Relaxation Algorithm) is an upwind-biased, point-implicit relaxation algorithm for obtaining the numerical solution to the governing equations for 3D viscous hypersonic flows in chemical and thermal nonequilibrium. The algorithm is derived using a finite-volume formulation in which the inviscid components of flux across cell walls are described with a modified Roe's averaging and with second-order corrections based on Yee's Symmetric Total Variation Diminishing scheme. The code has been applied to Problem 8.2 of this workshop for the case of thermochemical nonequilibrium flow through a nozzle. Chemical reaction rates are defined with the model of Park (1987). Thermal nonequilibrium is modeled using a two-temperature approximation in which the vibrational energies of all molecules are assumed to be in equilibrium at a single temperature which is generally different from the translational-rotational temperature. Two grids were used to define the flow for the original problem, with a stagnation temperature of 6500 K. A third case with a stagnation temperature of 10,000 K is also presented. The solution domain includes the converging nozzle, subsonic flow domain in which the gas is substantially in thermochemical equilibrium and the diverging nozzle, hypersonic flow domain in which the gas is substantially in thermochemical nonequilibrium.
    Keywords: AERODYNAMICS
    Type: In: Hypersonic flows for reentry problems. Vol. 2 (A93-42576 17-02); p. 1145-1158.
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  • 100
    Publication Date: 2011-08-24
    Description: Solutions have been computed and results are presented for Problem 1, the case of Mach 9 transitional flow past a 7 deg half-angle cone at zero incidence. The solutions were computed using a code developed for the integration of the parabolized Navier-Stokes equations. The algorithm employed in the code is based on a Roe-type flux-difference-splitting scheme applied following a finite-volume approach. The basic algorithm has been modified to make it implicit and second-order accurate in the crossflow directions. Results are presented in terms of surface pressure and heat transfer as well as boundary layer profiles of pitot pressure, Mach number, and tangential velocity. The case was recalculated several times in an effort to determine sensitivities to such parameters as grid density, wall temperature, turbulence model parameters, as well as freestream expansion. Comparisons with the experimental data are presented and discussed.
    Keywords: AERODYNAMICS
    Type: In: Hypersonic flows for reentry problems. Vol. 2 (A93-42576 17-02); p. 75-91.
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