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  • United States  (123)
  • Mice, Inbred C57BL  (42)
  • American Association for the Advancement of Science (AAAS)  (165)
  • Hindawi
  • Springer Nature
  • 2010-2014  (165)
  • 1980-1984
  • 2013  (165)
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  • 2010-2014  (165)
  • 1980-1984
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  • 1
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    Extra oversight for H7N9 experiments (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaffe, Harold -- Patterson, Amy P -- Lurie, Nicole -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):713-4. doi: 10.1126/science.1244158. Epub 2013 Aug 7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23926189" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research ; Containment of Biohazards ; *Government Regulation ; *Influenza A virus/genetics/pathogenicity/physiology ; Mammals ; Orthomyxoviridae Infections/transmission/*virology ; Risk Assessment ; Safety Management ; United States ; *United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reconstructing the microbial diversity and function of pre-agricultural tallgrass prairie soils in the United States (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: Native tallgrass prairie once dominated much of the midwestern United States, but this biome and the soil microbial diversity that once sustained this highly productive system have been almost completely eradicated by decades of agricultural practices. We reconstructed the soil microbial diversity that once existed in this biome by analyzing relict prairie soils and found that the biogeographical patterns were largely driven by changes in the relative abundance of Verrucomicrobia, a poorly studied bacterial phylum that appears to dominate many prairie soils. Shotgun metagenomic data suggested that these spatial patterns were associated with strong shifts in carbon dynamics. We show that metagenomic approaches can be used to reconstruct below-ground biogeochemical and diversity gradients in endangered ecosystems; such information could be used to improve restoration efforts, given that even small changes in below-ground microbial diversity can have important impacts on ecosystem processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fierer, Noah -- Ladau, Joshua -- Clemente, Jose C -- Leff, Jonathan W -- Owens, Sarah M -- Pollard, Katherine S -- Knight, Rob -- Gilbert, Jack A -- McCulley, Rebecca L -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):621-4. doi: 10.1126/science.1243768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179225" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Archaea/*classification/genetics/isolation & purification ; Bacteria/*classification/genetics/isolation & purification ; *Biodiversity ; *Endangered Species ; Metagenomics ; Poaceae ; *Soil ; *Soil Microbiology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    B cells use mechanical energy to discriminate antigen affinities (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: The generation of high-affinity antibodies depends on the ability of B cells to extract antigens from the surfaces of antigen-presenting cells. B cells that express high-affinity B cell receptors (BCRs) acquire more antigen and obtain better T cell help. However, the mechanisms by which B cells extract antigen remain unclear. Using fluid and flexible membrane substrates to mimic antigen-presenting cells, we showed that B cells acquire antigen by dynamic myosin IIa-mediated contractions that pull out and invaginate the presenting membranes. The forces generated by myosin IIa contractions ruptured most individual BCR-antigen bonds and promoted internalization of only high-affinity, multivalent BCR microclusters. Thus, B cell contractility contributes to affinity discrimination by mechanically testing the strength of antigen binding.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713314/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713314/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Natkanski, Elizabeth -- Lee, Wing-Yiu -- Mistry, Bhakti -- Casal, Antonio -- Molloy, Justin E -- Tolar, Pavel -- MC_U117570592/Medical Research Council/United Kingdom -- MC_U117597138/Medical Research Council/United Kingdom -- U117570592/Medical Research Council/United Kingdom -- U117597138/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2013 Jun 28;340(6140):1587-90. doi: 10.1126/science.1237572. Epub 2013 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immune Cell Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23686338" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Affinity ; *Antigen Presentation ; Antigens/*immunology ; B-Lymphocytes/*immunology ; Cells, Cultured ; Mechanical Processes ; Mice ; Mice, Inbred C57BL ; Microscopy, Atomic Force ; Nonmuscle Myosin Type IIA/*physiology ; Receptors, Antigen, B-Cell/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Role of tissue protection in lethal respiratory viral-bacterial coinfection (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-27
    Description: Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this increased susceptibility, however, is not well defined. Host defense from infection relies not only on immune resistance mechanisms but also on the ability to tolerate a given level of pathogen burden. Failure of either resistance or tolerance can contribute to disease severity, making it hard to distinguish their relative contribution. We employ a coinfection mouse model of influenza virus and Legionella pneumophila in which we can separate resistance and tolerance. We demonstrate that influenza virus can promote susceptibility to lethal bacterial coinfection, even when bacterial infection is controlled by the immune system. We propose that this failure of host defense is due to impaired ability to tolerate tissue damage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933032/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933032/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jamieson, Amanda M -- Pasman, Lesley -- Yu, Shuang -- Gamradt, Pia -- Homer, Robert J -- Decker, Thomas -- Medzhitov, Ruslan -- AI R01 055502/AI/NIAID NIH HHS/ -- R01 046688/PHS HHS/ -- R01 AI046688/AI/NIAID NIH HHS/ -- R01 AI055502/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jun 7;340(6137):1230-4. doi: 10.1126/science.1233632. Epub 2013 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. amanda_jamieson@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23618765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caspase 1 ; Coinfection/*immunology/pathology ; Disease Models, Animal ; Host-Pathogen Interactions/immunology ; Interleukin-1beta/metabolism ; *Legionella pneumophila ; Legionnaires' Disease/*immunology/pathology ; Lung/microbiology/pathology/virology ; Mice ; Mice, Inbred C57BL ; *Orthomyxoviridae ; Orthomyxoviridae Infections/*immunology/pathology ; Pneumonia, Bacterial/*immunology/pathology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 3/metabolism ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Education. Can rating pre-K programs predict children's learning? (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabol, T J -- Soliday Hong, S L -- Pianta, R C -- Burchinal, M R -- New York, N.Y. -- Science. 2013 Aug 23;341(6148):845-6. doi: 10.1126/science.1233517.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Policy Research, Northwestern University, Evanston, IL 60208, USA. terri.sabol@northwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23970684" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Educational Measurement/*methods ; *Educational Status ; Faculty ; Humans ; Language ; *Learning ; Mathematics/education ; Program Evaluation/*methods ; Reading ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Science & SciLifeLab Prize. Stop, go, and evolve (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Victora, Gabriel D -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1186. doi: 10.1126/science.1247567.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311676" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/genetics/*immunology ; Antibody Affinity ; Antibody Formation ; Awards and Prizes ; B-Lymphocytes/*immunology ; Cell Movement ; Cell Proliferation ; *Evolution, Molecular ; Germinal Center/cytology/*immunology ; History, 21st Century ; Mice ; Mice, Transgenic ; Somatic Hypermutation, Immunoglobulin ; T-Lymphocytes, Helper-Inducer/immunology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Environmental science. Water in the balance (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Famiglietti, James S -- Rodell, Matthew -- New York, N.Y. -- Science. 2013 Jun 14;340(6138):1300-1. doi: 10.1126/science.1236460.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UC Center for Hydrologic Modeling, University of California, Irvine, CA 92697, USA. jfamigli@uci.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23766323" target="_blank"〉PubMed〈/a〉
    Keywords: Agricultural Irrigation ; *Climate Change ; Environmental Monitoring/*methods ; Floods ; Germany ; *Groundwater ; United States ; *Water Supply
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    A cancer to-do list (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2013 Oct 25;342(6157):418. doi: 10.1126/science.342.6157.418.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24159026" target="_blank"〉PubMed〈/a〉
    Keywords: Developing Countries ; Humans ; National Cancer Institute (U.S.)/*economics ; Neoplasms/*economics/*epidemiology ; Obesity/epidemiology ; Registries ; Risk ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Global epigenomic reconfiguration during mammalian brain development (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-06
    Description: DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lister, Ryan -- Mukamel, Eran A -- Nery, Joseph R -- Urich, Mark -- Puddifoot, Clare A -- Johnson, Nicholas D -- Lucero, Jacinta -- Huang, Yun -- Dwork, Andrew J -- Schultz, Matthew D -- Yu, Miao -- Tonti-Filippini, Julian -- Heyn, Holger -- Hu, Shijun -- Wu, Joseph C -- Rao, Anjana -- Esteller, Manel -- He, Chuan -- Haghighi, Fatemeh G -- Sejnowski, Terrence J -- Behrens, M Margarita -- Ecker, Joseph R -- AI44432/AI/NIAID NIH HHS/ -- CA151535/CA/NCI NIH HHS/ -- HD065812/HD/NICHD NIH HHS/ -- HG006827/HG/NHGRI NIH HHS/ -- K99NS080911/NS/NINDS NIH HHS/ -- MH094670/MH/NIMH NIH HHS/ -- R01 AI044432/AI/NIAID NIH HHS/ -- R01 CA151535/CA/NCI NIH HHS/ -- R01 HD065812/HD/NICHD NIH HHS/ -- R01 HG006827/HG/NHGRI NIH HHS/ -- R01 MH094670/MH/NIMH NIH HHS/ -- R01 MH094774/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ryan.lister@uwa.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828890" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/metabolism ; Adult ; Animals ; Base Sequence ; Conserved Sequence ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; *Epigenesis, Genetic ; Epigenomics ; Frontal Lobe/*growth & development ; *Gene Expression Regulation, Developmental ; Genome-Wide Association Study ; Humans ; Longevity ; Mice ; Mice, Inbred C57BL ; X Chromosome Inactivation/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    U.S. immigration policy. Visa reform advances in Senate as House offers STEM ideas (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2013 May 31;340(6136):1027. doi: 10.1126/science.340.6136.1027.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23723210" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration/*legislation & jurisprudence ; *Engineering ; *Mathematics ; *Science ; *Technology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    New team, old hands (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):706-7. doi: 10.1126/science.341.6147.706.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950507" target="_blank"〉PubMed〈/a〉
    Keywords: Research/*organization & administration ; *Science ; United States ; United States Government Agencies/*organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Dual use research. New U.S. rules increase oversight of H5N1 studies, other risky science (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- Enserink, Martin -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1025. doi: 10.1126/science.339.6123.1025.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*standards ; *Guidelines as Topic ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/*prevention & control/*transmission ; Laboratories/standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    U.S. immigration reform. More high-tech visas, more STEM education funds (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):415-6. doi: 10.1126/science.340.6131.415.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620024" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration/*legislation & jurisprudence ; Engineering/economics/*education ; *Fees and Charges ; *Financial Management ; Mathematics/economics/*education ; Science/economics/*education ; Technology/economics/*education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Caspase-11 protects against bacteria that escape the vacuole (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-26
    Description: Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria. Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, specific mutants (sifA and sdhA, respectively) aberrantly enter the cytosol. These mutants triggered caspase-11, which enhanced clearance of S. typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways. Burkholderia species that naturally invade the cytosol also triggered caspase-11, which protected mice from lethal challenge with B. thailandensis and B. pseudomallei. Thus, caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697099/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697099/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aachoui, Youssef -- Leaf, Irina A -- Hagar, Jon A -- Fontana, Mary F -- Campos, Cristine G -- Zak, Daniel E -- Tan, Michael H -- Cotter, Peggy A -- Vance, Russell E -- Aderem, Alan -- Miao, Edward A -- AI057141/AI/NIAID NIH HHS/ -- AI063302/AI/NIAID NIH HHS/ -- AI065359/AI/NIAID NIH HHS/ -- AI075039/AI/NIAID NIH HHS/ -- AI080749/AI/NIAID NIH HHS/ -- AI097518/AI/NIAID NIH HHS/ -- P01 AI063302/AI/NIAID NIH HHS/ -- P30 CA016086/CA/NCI NIH HHS/ -- R01 AI075039/AI/NIAID NIH HHS/ -- R01 AI080749/AI/NIAID NIH HHS/ -- R01 AI097518/AI/NIAID NIH HHS/ -- U19 AI100627/AI/NIAID NIH HHS/ -- U54 AI057141/AI/NIAID NIH HHS/ -- U54 AI065359/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):975-8. doi: 10.1126/science.1230751. Epub 2013 Jan 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23348507" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burkholderia/pathogenicity/physiology ; Burkholderia Infections/enzymology/immunology/metabolism ; Burkholderia pseudomallei/pathogenicity/physiology ; Caspases/*metabolism ; *Cell Death ; Cytosol/*microbiology ; Gram-Negative Bacterial Infections/enzymology/*immunology/microbiology ; Immunity, Innate ; Inflammasomes/metabolism ; Macrophages/immunology/*microbiology ; Mice ; Mice, Inbred C57BL ; Phagosomes/microbiology ; Salmonella Infections, Animal/enzymology/immunology/microbiology ; Salmonella typhimurium/pathogenicity/physiology ; Vacuoles/*microbiology
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    Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that combined exposure to prenatal immune challenge and peripubertal stress induces synergistic pathological effects on adult behavioral functions and neurochemistry. We further demonstrate that the prenatal insult markedly increases the vulnerability of the pubescent offspring to brain immune changes in response to stress. Our findings reveal interactions between two adverse environmental factors that have individually been associated with neuropsychiatric disease and support theories that mental illnesses with delayed onsets involve multiple environmental hits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giovanoli, Sandra -- Engler, Harald -- Engler, Andrea -- Richetto, Juliet -- Voget, Mareike -- Willi, Roman -- Winter, Christine -- Riva, Marco A -- Mortensen, Preben B -- Feldon, Joram -- Schedlowski, Manfred -- Meyer, Urs -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1095-9. doi: 10.1126/science.1228261.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/immunology ; Disease Models, Animal ; Female ; Humans ; Mental Disorders/*immunology ; Mice ; Mice, Inbred C57BL ; Poly I-C/immunology/pharmacology ; Pregnancy ; Prenatal Exposure Delayed Effects/*immunology/virology ; Puberty/*immunology ; Stress, Physiological/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Interstitial dendritic cell guidance by haptotactic chemokine gradients (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-19
    Description: Directional guidance of cells via gradients of chemokines is considered crucial for embryonic development, cancer dissemination, and immune responses. Nevertheless, the concept still lacks direct experimental confirmation in vivo. Here, we identify endogenous gradients of the chemokine CCL21 within mouse skin and show that they guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots of CCL21 within lymphatic endothelial cells and steeply decaying gradients within the perilymphatic interstitium. These gradients match the migratory patterns of the dendritic cells, which directionally approach vessels from a distance of up to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and its experimental delocalization or swamping the endogenous gradients abolishes directed migration. These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weber, Michele -- Hauschild, Robert -- Schwarz, Jan -- Moussion, Christine -- de Vries, Ingrid -- Legler, Daniel F -- Luther, Sanjiv A -- Bollenbach, Tobias -- Sixt, Michael -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):328-32. doi: 10.1126/science.1228456.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IST Austria (Institute of Science and Technology Austria), Klosterneuburg, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329049" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chemokine CCL19/metabolism ; Chemokine CCL21/chemistry/*immunology ; Chemotaxis/*immunology ; Dendritic Cells/*immunology ; Heparitin Sulfate/chemistry ; Immobilized Proteins/chemistry/immunology ; Lymphatic Vessels/*immunology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Receptors, CCR7/genetics ; Skin/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Improving education standards (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coffey, Janet -- Alberts, Bruce -- New York, N.Y. -- Science. 2013 Feb 1;339(6119):489. doi: 10.1126/science.1225590.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23371979" target="_blank"〉PubMed〈/a〉
    Keywords: Science/*education ; Teaching/*standards ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Pharmaceuticals. Advocates protest the cost of a hepatitis C cure (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1302-3. doi: 10.1126/science.342.6164.1302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337268" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*economics/pharmacology/therapeutic use ; Consumer Advocacy ; *Cost of Illness ; Drug Approval ; Drugs, Generic/economics/pharmacology/therapeutic use ; Hepacivirus/drug effects/genetics ; Hepatitis C/*drug therapy/epidemiology/virology ; Humans ; Prevalence ; Sofosbuvir ; United States ; United States Food and Drug Administration ; Uridine Monophosphate/*analogs & derivatives/economics/pharmacology/therapeutic ; use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Varmus's second act (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 Oct 25;342(6157):416-9. doi: 10.1126/science.342.6157.416.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24159025" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/history/trends ; Budgets/*history ; History, 19th Century ; History, 20th Century ; Humans ; National Cancer Institute (U.S.)/economics/*history ; United States
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    Scientific exchange. Marine studies show potential for U.S.-Cuban collaboration (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman-Rudovsky, Jean -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):446-7. doi: 10.1126/science.341.6145.446.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908199" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bass ; Cuba ; *Endangered Species ; *International Cooperation ; Marine Biology/*trends ; United States
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  • 21
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    Epidemiology. Budget woes threaten long-term heart studies (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):701. doi: 10.1126/science.341.6147.701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950503" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Cardiovascular Diseases ; *Cohort Studies ; Financing, Government ; Humans ; National Heart, Lung, and Blood Institute (U.S.)/*economics ; United States
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    Science education. Increasing persistence of college students in STEM (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, Mark J -- Frederick, Jennifer -- Byars-Winston, Angela -- Hunter, Anne-Barrie -- Handelsman, Jo -- 1R13GM090574-01/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1455-6. doi: 10.1126/science.1240487.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Scientific Teaching, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072909" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/*education ; Humans ; Mathematics/*education ; Research ; *Retention (Psychology) ; Science/*education ; Students/*psychology ; Technology/*education ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Am I wrong? (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2013 Mar 15;339(6125):1252. doi: 10.1126/science.1237434.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23493681" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Foundations ; Science/*economics/*trends ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Primate studies. Research in limbo as Harvard moves to close center (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 May 3;340(6132):535. doi: 10.1126/science.340.6132.535.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641084" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research/economics ; Budgets ; Financing, Government ; Massachusetts ; National Institutes of Health (U.S.)/economics ; *Primates ; *Schools, Medical/economics/organization & administration ; United States
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  • 25
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    Compartmentalization of GABAergic inhibition by dendritic spines (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-11
    Description: gamma-aminobutyric acid-mediated (GABAergic) inhibition plays a critical role in shaping neuronal activity in the neocortex. Numerous experimental investigations have examined perisomatic inhibitory synapses, which control action potential output from pyramidal neurons. However, most inhibitory synapses in the neocortex are formed onto pyramidal cell dendrites, where theoretical studies suggest they may focally regulate cellular activity. The precision of GABAergic control over dendritic electrical and biochemical signaling is unknown. By using cell type-specific optical stimulation in combination with two-photon calcium (Ca(2+)) imaging, we show that somatostatin-expressing interneurons exert compartmentalized control over postsynaptic Ca(2+) signals within individual dendritic spines. This highly focal inhibitory action is mediated by a subset of GABAergic synapses that directly target spine heads. GABAergic inhibition thus participates in localized control of dendritic electrical and biochemical signaling.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752161/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752161/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiu, Chiayu Q -- Lur, Gyorgy -- Morse, Thomas M -- Carnevale, Nicholas T -- Ellis-Davies, Graham C R -- Higley, Michael J -- DC009977/DC/NIDCD NIH HHS/ -- GM053395/GM/NIGMS NIH HHS/ -- K01 MH097961/MH/NIMH NIH HHS/ -- MH099045/MH/NIMH NIH HHS/ -- NS011613/NS/NINDS NIH HHS/ -- NS069720/NS/NINDS NIH HHS/ -- R01 DC009977/DC/NIDCD NIH HHS/ -- R01 GM053395/GM/NIGMS NIH HHS/ -- R01 MH099045/MH/NIMH NIH HHS/ -- R01 NS011613/NS/NINDS NIH HHS/ -- R01 NS069720/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 10;340(6133):759-62. doi: 10.1126/science.1234274.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661763" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Computer Simulation ; Dendritic Spines/*physiology ; Female ; Glutamic Acid/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Models, Neurological ; Neocortex/*physiology ; *Neural Inhibition ; Photic Stimulation ; Pyramidal Cells/*physiology ; Rhodopsin/metabolism ; Synapses/physiology ; gamma-Aminobutyric Acid/*physiology
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    Why national science academies? (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1011. doi: 10.1126/science.1236831.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449561" target="_blank"〉PubMed〈/a〉
    Keywords: Anniversaries and Special Events ; *National Academy of Sciences (U.S.) ; United States
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    Biomedicine. Rare cancer successes spawn 'exceptional' research efforts (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):263. doi: 10.1126/science.340.6130.263.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599454" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Antineoplastic Agents/*therapeutic use ; Biomarkers, Pharmacological ; Biomedical Research ; Clinical Trials, Phase I as Topic ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Drug Resistance, Neoplasm ; Everolimus ; Female ; Humans ; National Cancer Institute (U.S.) ; Remission Induction ; Sirolimus/analogs & derivatives/therapeutic use ; Tumor Suppressor Proteins/genetics ; United States ; Urinary Bladder Neoplasms/*drug therapy/*genetics ; Uterine Neoplasms/*drug therapy/*genetics
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    Scientific publishing. U.S. agencies directed to make research papers available (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1021. doi: 10.1126/science.339.6123.1021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449567" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Periodicals as Topic ; Research/*economics ; United States
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  • 29
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    Interferon-epsilon protects the female reproductive tract from viral and bacterial infection (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-epsilon as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-epsilon was not induced by known PRR pathways; instead, IFN-epsilon was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-epsilon-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-epsilon is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617553/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617553/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fung, Ka Yee -- Mangan, Niamh E -- Cumming, Helen -- Horvat, Jay C -- Mayall, Jemma R -- Stifter, Sebastian A -- De Weerd, Nicole -- Roisman, Laila C -- Rossjohn, Jamie -- Robertson, Sarah A -- Schjenken, John E -- Parker, Belinda -- Gargett, Caroline E -- Nguyen, Hong P T -- Carr, Daniel J -- Hansbro, Philip M -- Hertzog, Paul J -- R01 AI053108/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1088-92. doi: 10.1126/science.1233321.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chlamydia Infections/genetics/*immunology ; *Chlamydia muridarum ; Estrogens/administration & dosage/immunology ; Female ; HEK293 Cells ; Herpes Genitalis/genetics/*immunology ; *Herpesvirus 2, Human ; Humans ; Interferons/genetics/*immunology ; Ligands ; Mice ; Mice, Inbred C57BL ; Oligodeoxyribonucleotides/immunology ; Poly I-C/immunology ; Poly dA-dT/immunology ; Toll-Like Receptors/*immunology ; Uterus/immunology ; Vagina/*immunology/microbiology/virology
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    The children's study: unmet promises (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):133-6. doi: 10.1126/science.339.6116.133.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307717" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Child ; *Child Development ; Child Welfare ; Child, Preschool ; Costs and Cost Analysis ; *Environment ; *Environmental Exposure ; Epidemiologic Research Design ; *Epidemiologic Studies ; *Health ; Humans ; Infant ; Infant, Newborn ; *National Institute of Child Health and Human Development (U.S.) ; Pilot Projects ; Social Environment ; United States ; Young Adult
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    Infectious disease. Approval of novel TB drug celebrated--with restraint (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):130. doi: 10.1126/science.339.6116.130.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307714" target="_blank"〉PubMed〈/a〉
    Keywords: *Antitubercular Agents/adverse effects/pharmacology/therapeutic use ; Clinical Trials as Topic ; Diarylquinolines ; *Drug Approval ; Drug Resistance, Multiple, Bacterial ; Drug Therapy, Combination ; Humans ; Mycobacterium tuberculosis/*drug effects/enzymology ; *Quinolines/adverse effects/pharmacology/therapeutic use ; Tuberculosis, Multidrug-Resistant/*drug therapy/microbiology ; United States ; United States Food and Drug Administration
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    Science funding. U.S. shutdown spares an 'essential' few (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- Malakoff, David -- Mervis, Jeffrey -- Pennisi, Elizabeth -- Servick, Kelly -- New York, N.Y. -- Science. 2013 Oct 4;342(6154):22. doi: 10.1126/science.342.6154.22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24092705" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds ; Databases, Nucleic Acid/economics ; *Federal Government ; National Institutes of Health (U.S.)/economics ; Natural History/*economics ; PubMed/economics ; United States
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    Gut microbiomes of Malawian twin pairs discordant for kwashiorkor (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-02-01
    Description: Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became discordant, and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor gut microbiomes that regressed when administration of RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667500/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667500/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Michelle I -- Yatsunenko, Tanya -- Manary, Mark J -- Trehan, Indi -- Mkakosya, Rajhab -- Cheng, Jiye -- Kau, Andrew L -- Rich, Stephen S -- Concannon, Patrick -- Mychaleckyj, Josyf C -- Liu, Jie -- Houpt, Eric -- Li, Jia V -- Holmes, Elaine -- Nicholson, Jeremy -- Knights, Dan -- Ursell, Luke K -- Knight, Rob -- Gordon, Jeffrey I -- DK078669/DK/NIDDK NIH HHS/ -- DK30292/DK/NIDDK NIH HHS/ -- F32 DK091044/DK/NIDDK NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- P30 DK056341/DK/NIDDK NIH HHS/ -- R37 DK030292/DK/NIDDK NIH HHS/ -- T32 HD049338/HD/NICHD NIH HHS/ -- T32-HD049338/HD/NICHD NIH HHS/ -- T35 DK074375/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 1;339(6119):548-54. doi: 10.1126/science.1229000. Epub 2013 Jan 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23363771" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Arachis ; Carbohydrate Metabolism ; Child, Preschool ; Diseases in Twins/*microbiology ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Germ-Free Life ; Humans ; Infant ; Kwashiorkor/diet therapy/epidemiology/*microbiology ; Longitudinal Studies ; Malawi/epidemiology ; Male ; *Metagenome ; Mice ; Mice, Inbred C57BL
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    Economics. Doctoral students and U.S. immigration policy (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maskus, Keith E -- Mobarak, A Mushfiq -- Stuen, Eric T -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):562-3. doi: 10.1126/science.1239572.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Colorado at Boulder, Boulder, CO 80309, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179206" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate/*legislation & jurisprudence ; Emigrants and Immigrants/*education ; Emigration and Immigration/*legislation & jurisprudence ; Policy ; Students ; United States
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    Temperature drives the continental-scale distribution of key microbes in topsoil communities (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-03
    Description: Global warming will likely force terrestrial plant and animal species to migrate toward cooler areas or sustain range losses; whether this is also true for microorganisms remains unknown. Through continental-scale compositional surveys of soil crust microbial communities across arid North America, we observed a latitudinal replacement in dominance between two key topsoil cyanobacteria that was driven largely by temperature. The responses to temperature of enrichment cultures and cultivated strains support this contention, with one cyanobacterium (Microcoleus vaginatus) being more psychrotolerant and less thermotolerant than the other (M. steenstrupii). In view of our data and regional climate predictions, the latter cyanobacterium may replace the former in much of the studied area within the next few decades, with unknown ecological consequences for soil fertility and erodibility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia-Pichel, Ferran -- Loza, Virginia -- Marusenko, Yevgeniy -- Mateo, Pilar -- Potrafka, Ruth M -- New York, N.Y. -- Science. 2013 Jun 28;340(6140):1574-7. doi: 10.1126/science.1236404.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. ferran@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23812714" target="_blank"〉PubMed〈/a〉
    Keywords: Cyanobacteria/classification/isolation & purification/*physiology ; *Global Warming ; *Hot Temperature ; Phylogeny ; *Soil Microbiology ; United States
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    U.S. research spending. Sequester takes uneven bite from agency budgets (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Adrian -- Kaiser, Jocelyn -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1437-8. doi: 10.1126/science.341.6153.1437.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072895" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Budgets ; National Institutes of Health (U.S.)/*economics ; United States
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    Fear learning enhances neural responses to threat-predictive sensory stimuli (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-12-18
    Description: The central nervous system rapidly learns that particular stimuli predict imminent danger. This learning is thought to involve associations between neutral and harmful stimuli in cortical and limbic brain regions, though associative neuroplasticity in sensory structures is increasingly appreciated. We observed the synaptic output of olfactory sensory neurons (OSNs) in individual mice before and after they learned that a particular odor indicated an impending foot shock. OSNs are the first cells in the olfactory system, physically contacting the odor molecules in the nose and projecting their axons to the brain's olfactory bulb. OSN output evoked by the shock-predictive odor was selectively facilitated after fear conditioning. These results indicate that affective information about a stimulus can be encoded in its very earliest representation in the nervous system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011636/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011636/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kass, Marley D -- Rosenthal, Michelle C -- Pottackal, Joseph -- McGann, John P -- DC009442/DC/NIDCD NIH HHS/ -- DC013090/DC/NIDCD NIH HHS/ -- MH101293/MH/NIMH NIH HHS/ -- R00 DC009442/DC/NIDCD NIH HHS/ -- R01 DC013090/DC/NIDCD NIH HHS/ -- R01 MH101293/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1389-92. doi: 10.1126/science.1244916.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral and Systems Neuroscience Section, Department of Psychology, Rutgers, The State University of New Jersey, 152 Frelinghuysen Road, Piscataway, NJ 08854, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning, Classical/physiology ; Fear/*psychology ; Learning/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity ; *Odors ; Olfactory Receptor Neurons/*physiology ; Smell/*physiology ; Synapses/*physiology
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    The road to pollinator health (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woteki, Catherine -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):695. doi: 10.1126/science.1244271.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950499" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Animals ; *Bees ; *Colony Collapse ; Pollination ; *Research ; United States ; United States Department of Agriculture
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    Battle for the barrel (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2013 Mar 22;339(6126):1374-7, 1379. doi: 10.1126/science.339.6126.1374.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23520090" target="_blank"〉PubMed〈/a〉
    Keywords: *Biofuels ; Biomass ; *Cellulose ; *Ethanol ; Gasoline ; *Plants ; United States ; *Waste Products
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    Erythropoietin derived by chemical synthesis (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-18
    Description: Erythropoietin is a signaling glycoprotein that controls the fundamental process of erythropoiesis, orchestrating the production and maintenance of red blood cells. As administrated clinically, erythropoietin has a polypeptide backbone with complex dishomogeneity in its carbohydrate domains. Here we describe the total synthesis of homogeneous erythropoietin with consensus carbohydrate domains incorporated at all of the native glycosylation sites. The oligosaccharide sectors were built by total synthesis and attached stereospecifically to peptidyl fragments of the wild-type primary sequence, themselves obtained by solid-phase peptide synthesis. The glycopeptidyl constructs were joined by chemical ligation, followed by metal-free dethiylation, and subsequently folded. This homogeneous erythropoietin glycosylated at the three wild-type aspartates with N-linked high-mannose sialic acid-containing oligosaccharides and O-linked glycophorin exhibits Procrit-level in vivo activity in mice.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080428/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080428/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Ping -- Dong, Suwei -- Shieh, Jae-Hung -- Peguero, Elizabeth -- Hendrickson, Ronald -- Moore, Malcolm A S -- Danishefsky, Samuel J -- HL025848/HL/NHLBI NIH HHS/ -- P30 CA008748/CA/NCI NIH HHS/ -- R01 GM109760/GM/NIGMS NIH HHS/ -- R01 HL025848/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1357-60. doi: 10.1126/science.1245095.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337294" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Aspartic Acid/chemistry ; Cells, Cultured ; Consensus Sequence ; Dose-Response Relationship, Drug ; Erythrocyte Count ; Erythropoietin/*administration & dosage/*chemical synthesis/chemistry ; Glycophorin/chemistry ; Glycosylation ; Injections, Subcutaneous ; Mannose/chemistry ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; N-Acetylneuraminic Acid/chemistry ; Oligosaccharides/chemistry ; Reticulocytes/drug effects
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    Science funding. U.S. shutdown tightens its grip on research (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2013 Oct 11;342(6155):176-7. doi: 10.1126/science.342.6155.176.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24115413" target="_blank"〉PubMed〈/a〉
    Keywords: Capital Financing/*economics ; *Federal Government ; Research/*economics ; United States
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    Sleep drives metabolite clearance from the adult brain (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-10-19
    Description: The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of beta-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie, Lulu -- Kang, Hongyi -- Xu, Qiwu -- Chen, Michael J -- Liao, Yonghong -- Thiyagarajan, Meenakshisundaram -- O'Donnell, John -- Christensen, Daniel J -- Nicholson, Charles -- Iliff, Jeffrey J -- Takano, Takahiro -- Deane, Rashid -- Nedergaard, Maiken -- NS028642/NS/NINDS NIH HHS/ -- NS078167/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- R01 DE022743/DE/NIDCR NIH HHS/ -- R01 NS075177/NS/NINDS NIH HHS/ -- R01 NS078167/NS/NINDS NIH HHS/ -- R01 NS078304/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136970" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Antagonists/administration & dosage ; Amyloid beta-Peptides/*metabolism ; Animals ; Brain/*metabolism/physiology ; Cerebral Cortex/metabolism/physiology ; Cerebrospinal Fluid/metabolism ; Diffusion ; Electroencephalography ; Extracellular Space ; Intracellular Space ; Male ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/*metabolism ; Quaternary Ammonium Compounds/chemistry ; Receptors, Adrenergic/metabolism ; Sleep/*physiology ; Wakefulness/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Prizes. Cell transport win long overdue (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- Underwood, Emily -- New York, N.Y. -- Science. 2013 Oct 11;342(6155):175-6. doi: 10.1126/science.342.6155.175-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24115412" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Cell Biology/*history ; History, 20th Century ; History, 21st Century ; *Nobel Prize ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate policy. U.S. carbon plan relies on uncertain capture technology (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1438-9. doi: 10.1126/science.341.6153.1438.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072896" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/*prevention & control ; *Carbon Dioxide ; *Coal ; Global Warming/*prevention & control ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science education. Opportunities and challenges in next generation standards (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stage, E K -- Asturias, H -- Cheuk, T -- Daro, P A -- Hampton, S B -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):276-7. doi: 10.1126/science.1234011.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lawrence Hall of Science, University of California, Berkeley, Berkeley, CA 94720, USA. stage@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599466" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/*education/standards ; Language Arts/*standards ; Mathematics/*education/standards ; National Academy of Sciences (U.S.) ; Schools/*standards ; Science/*education/standards ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate science. Researchers wary as DOE bids to build sixth U.S. climate model (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2013 Sep 13;341(6151):1160. doi: 10.1126/science.341.6151.1160.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24030992" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Computer Simulation ; *Models, Theoretical ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Public health. Confronting the sorry state of U.S. health (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bayer, Ronald -- Fairchild, Amy L -- Hopper, Kim -- Nathanson, Constance A -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):962-3. doi: 10.1126/science.1241249.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. rb8@cumc.columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990546" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Health Services Accessibility/*ethics ; *Health Status ; Longevity ; Poverty ; *Social Justice ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate change. Hansen's retirement from NASA spurs look at his legacy (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2013 May 3;340(6132):540-1. doi: 10.1126/science.340.6132.540.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641087" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate Change ; History, 20th Century ; History, 21st Century ; Public Policy ; United States ; United States National Aeronautics and Space Administration/*organization & ; administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A neural circuit for memory specificity and generalization (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-16
    Description: Increased fear memory generalization is associated with posttraumatic stress disorder, but the circuit mechanisms that regulate memory specificity remain unclear. Here, we define a neural circuit-composed of the medial prefrontal cortex, the nucleus reuniens (NR), and the hippocampus-that controls fear memory generalization. Inactivation of prefrontal inputs into the NR or direct silencing of NR projections enhanced fear memory generalization, whereas constitutive activation of NR neurons decreased memory generalization. Direct optogenetic activation of phasic and tonic action-potential firing of NR neurons during memory acquisition enhanced or reduced memory generalization, respectively. We propose that the NR determines the specificity and generalization of memory attributes for a particular context by processing information from the medial prefrontal cortex en route to the hippocampus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651700/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651700/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Wei -- Sudhof, Thomas C -- K99 MH099153/MH/NIMH NIH HHS/ -- NS077906/NS/NINDS NIH HHS/ -- P50 MH086403/MH/NIMH NIH HHS/ -- R01 NS077906/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Mar 15;339(6125):1290-5. doi: 10.1126/science.1229534.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94304-5453, USA. weixu@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23493706" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Dependovirus ; Fear/*physiology ; *Generalization (Psychology) ; Green Fluorescent Proteins/genetics/metabolism ; Hippocampus/physiology ; Male ; Memory/*physiology ; Mice ; Mice, Inbred C57BL ; Midline Thalamic Nuclei/physiology ; Neural Pathways ; Prefrontal Cortex/*physiology ; Synapses/physiology ; Vesicle-Associated Membrane Protein 2/genetics/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Research ethics. Global research integrity training (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steneck, Nicholas H -- 2UL1TR000433/TR/NCATS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 3;340(6132):552-3. doi: 10.1126/science.1236373.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Ethics and Integrity Program, Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48103, USA. nsteneck@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641099" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Ethics, Research/*education ; *International Cooperation ; Internet ; Research/education/*standards ; Research Personnel/*education ; Scientific Misconduct ; Teaching Materials ; United States ; United States Office of Research Integrity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The new generation of sea scientist (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2013 Mar 8;339(6124):1141. doi: 10.1126/science.339.6124.1141.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23471382" target="_blank"〉PubMed〈/a〉
    Keywords: Marine Biology/*education/*manpower ; Oceanography/*education/*manpower ; Research Personnel/*education/*statistics & numerical data ; Ships ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A business view on U.S. education (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-20
    Description: Business leaders depend on an education system capable of providing a workforce able to compete in a global marketplace. As a partner in education reform, the business community advocates for an increased focus on helping schools connect students more effectively to the world of work through hands-on problem-solving activities and practical experiences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephens, Rick -- Richey, Mike -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):313-4. doi: 10.1126/science.1230728.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉rickstephens@me.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599482" target="_blank"〉PubMed〈/a〉
    Keywords: *Commerce ; Education/*economics ; Humans ; *Problem Solving ; Unemployment/*trends ; United States ; Work/*economics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A sea change for U.S. oceanography (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2013 Mar 8;339(6124):1138-43. doi: 10.1126/science.339.6124.1138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23471381" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Marine Biology/*economics ; Oceanography/*economics ; Research/economics ; Ships/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. science policy. Proposed change in awarding grants at NSF spurs partisan sniping (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 May 10;340(6133):670. doi: 10.1126/science.340.6133.670.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661731" target="_blank"〉PubMed〈/a〉
    Keywords: Awards and Prizes ; *Financing, Organized ; *Foundations ; Policy ; Science/*education ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. science policy. Bill would set new rules for choosing NSF grants (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 May 3;340(6132):534. doi: 10.1126/science.340.6132.534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641083" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Peer Review, Research/*legislation & jurisprudence ; Politics ; Public Policy ; Research Support as Topic/*legislation & jurisprudence ; United States ; United States Government Agencies/economics/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    2014 U.S. budget. Wild cards remain after proposed reshuffle of STEM education (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):258-9. doi: 10.1126/science.340.6130.258.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599451" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Engineering/economics/*education ; Federal Government ; Government Programs/*economics ; Mathematics/economics/*education ; Science/economics/*education ; Technology/economics/*education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. budget. U.S. science agencies finally have (reduced) budgets for this year (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Mar 29;339(6127):1511. doi: 10.1126/science.339.6127.1511.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23539574" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Science/*economics ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    2014 U.S. budget. Request would let science rebound from sequester (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):257. doi: 10.1126/science.340.6130.257.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599450" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Federal Government ; Science/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    What awaits the new NSF director (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1145. doi: 10.1126/science.1248875.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311646" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; *Research ; Research Support as Topic ; United States ; United States Government Agencies/legislation & jurisprudence/*organization & ; administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 60
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    Dust and biological aerosols from the Sahara and Asia influence precipitation in the western U.S (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: Winter storms in California's Sierra Nevada increase seasonal snowpack and provide critical water resources and hydropower for the state. Thus, the mechanisms influencing precipitation in this region have been the subject of research for decades. Previous studies suggest Asian dust enhances cloud ice and precipitation, whereas few studies consider biological aerosols as an important global source of ice nuclei (IN). Here, we show that dust and biological aerosols transported from as far as the Sahara were present in glaciated high-altitude clouds coincident with elevated IN concentrations and ice-induced precipitation. This study presents the first direct cloud and precipitation measurements showing that Saharan and Asian dust and biological aerosols probably serve as IN and play an important role in orographic precipitation processes over the western United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Creamean, Jessie M -- Suski, Kaitlyn J -- Rosenfeld, Daniel -- Cazorla, Alberto -- DeMott, Paul J -- Sullivan, Ryan C -- White, Allen B -- Ralph, F Martin -- Minnis, Patrick -- Comstock, Jennifer M -- Tomlinson, Jason M -- Prather, Kimberly A -- New York, N.Y. -- Science. 2013 Mar 29;339(6127):1572-8. doi: 10.1126/science.1227279. Epub 2013 Feb 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449996" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/*chemistry ; Africa, Northern ; *Altitude ; Asia ; Atmosphere/*chemistry ; Bacteria ; *Dust ; *Freezing ; *Ice ; Models, Chemical ; Rain/chemistry ; Seasons ; Snow/chemistry ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Bricks and MOOCs (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2013 Oct 25;342(6157):402. doi: 10.1126/science.1246943.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24159014" target="_blank"〉PubMed〈/a〉
    Keywords: *Developing Countries ; Education, Distance/*methods ; Online Systems/*utilization ; United States ; *Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. science policy. What it means for agencies to be under the sequester (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1020-1. doi: 10.1126/science.339.6123.1020.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449566" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Foundations ; National Institutes of Health (U.S.)/economics ; Science/*economics ; United States ; United States Government Agencies/*economics
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    U.S. budget. Sequestration takes aim at federal science spending (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):127-9. doi: 10.1126/science.339.6116.127.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307712" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; *Federal Government ; Financing, Government/*legislation & jurisprudence ; *Politics ; Research/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science funding. U.S. budget deal offers researchers some sequester relief (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1426-7. doi: 10.1126/science.342.6165.1426.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357280" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Research Personnel/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Leveling the playing field (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2013 Jul 26;341(6144):317. doi: 10.1126/science.1242309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23888005" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Career Mobility ; *Engineering/manpower ; Female ; Humans ; Medicine ; National Academy of Sciences (U.S.) ; Organizations ; *Science/manpower ; United States ; *Women, Working
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    U.S. Science policy. NSF opening adds to concerns about Obama's second-term science team (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):746-7. doi: 10.1126/science.339.6121.746.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23413328" target="_blank"〉PubMed〈/a〉
    Keywords: Capital Financing/*organization & administration ; Foundations/*economics ; Science/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Persistent LCMV infection is controlled by blockade of type I interferon signaling (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-13
    Description: During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. IFN-I blockade before and after establishment of persistent virus infection resulted in enhanced virus clearance and was CD4 T cell-dependent. Hence, we demonstrate a direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence. Our results suggest that therapies targeting IFN-I may help control persistent virus infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640797/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640797/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teijaro, John R -- Ng, Cherie -- Lee, Andrew M -- Sullivan, Brian M -- Sheehan, Kathleen C F -- Welch, Megan -- Schreiber, Robert D -- de la Torre, Juan Carlos -- Oldstone, Michael B A -- AI007354/AI/NIAID NIH HHS/ -- AI047140/AI/NIAID NIH HHS/ -- AI077719/AI/NIAID NIH HHS/ -- AI09484/AI/NIAID NIH HHS/ -- CA43059/CA/NCI NIH HHS/ -- HL007195/HL/NHLBI NIH HHS/ -- NS041219/NS/NINDS NIH HHS/ -- R01 AI009484/AI/NIAID NIH HHS/ -- R01 AI047140/AI/NIAID NIH HHS/ -- R01 AI077719/AI/NIAID NIH HHS/ -- U54 AI057160/AI/NIAID NIH HHS/ -- U54AI057160/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 12;340(6129):207-11. doi: 10.1126/science.1235214.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23580529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/blood ; Antigens, CD274/metabolism ; Arenaviridae Infections/*immunology/pathology/*virology ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Dendritic Cells/immunology/virology ; Female ; Immune Tolerance ; Interferon Type I/immunology/*metabolism ; Interleukin-10/metabolism ; Lymphocytes/immunology/virology ; Lymphocytic choriomeningitis virus/*immunology/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/immunology/metabolism ; *Signal Transduction ; Spleen/immunology/pathology ; Viremia
    Print ISSN: 0036-8075
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    Technology. Advanced manufacturing policies and paradigms for innovation (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonvillian, William B -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1173-5. doi: 10.1126/science.1242210.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Director, Washington Office, Massachusetts Institute of Technology, Washington, DC 20002, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311668" target="_blank"〉PubMed〈/a〉
    Keywords: *Industry ; *Inventions ; *Policy ; Research ; *Technology ; United States
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    TH17 cell differentiation is regulated by the circadian clock (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-10
    Description: Circadian clocks regulate numerous physiological processes that vary across the day-night (diurnal) cycle, but if and how the circadian clock regulates the adaptive immune system is mostly unclear. Interleukin-17-producing CD4(+) T helper (T(H)17) cells are proinflammatory immune cells that protect against bacterial and fungal infections at mucosal surfaces. Their lineage specification is regulated by the orphan nuclear receptor RORgammat. We show that the transcription factor NFIL3 suppresses T(H)17 cell development by directly binding and repressing the Rorgammat promoter. NFIL3 links T(H)17 cell development to the circadian clock network through the transcription factor REV-ERBalpha. Accordingly, TH17 lineage specification varies diurnally and is altered in Rev-erbalpha(-/-) mice. Light-cycle disruption elevated intestinal T(H)17 cell frequencies and increased susceptibility to inflammatory disease. Thus, lineage specification of a key immune cell is under direct circadian control.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165400/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165400/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Xiaofei -- Rollins, Darcy -- Ruhn, Kelly A -- Stubblefield, Jeremy J -- Green, Carla B -- Kashiwada, Masaki -- Rothman, Paul B -- Takahashi, Joseph S -- Hooper, Lora V -- R01 DK070855/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24202171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basic-Leucine Zipper Transcription Factors/genetics/*metabolism ; CLOCK Proteins/genetics ; Cell Differentiation/*genetics ; Cell Lineage/genetics ; Circadian Clocks/genetics/*immunology ; *Gene Expression Regulation ; Germ-Free Life ; HEK293 Cells ; Humans ; Intestine, Small/immunology/microbiology ; Jurkat Cells ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Nuclear Receptor Subfamily 1, Group D, Member 1/genetics/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/*genetics ; Promoter Regions, Genetic ; Th17 Cells/*cytology
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    Science education. New head of advocacy group plans to 'fight the good fight' (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1030. doi: 10.1126/science.342.6162.1030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288310" target="_blank"〉PubMed〈/a〉
    Keywords: Science/*education/*manpower ; United States ; United States Government Agencies
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    Social science. A U.K. view on the U.S. attack on social sciences (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boyle, Paul -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):719. doi: 10.1126/science.1242563.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UK Economic and Social Research Council (ESRC), Swindon, UK. ESRC.CEO@esrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950516" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Great Britain ; Humans ; *Politics ; *Research ; *Research Support as Topic ; *Social Sciences ; United States ; United States Government Agencies/economics
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    Science funding. U.S. shutdown ends, but not budget anxiety (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Oct 25;342(6157):410-1. doi: 10.1126/science.342.6157.410.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24159020" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Science/*economics ; United States
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    Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4 (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression of allergic inflammation and diseases such as asthma. A mechanism that links these inflammatory mediators is essential for explaining the fundamental basis of allergic disease but has been elusive. Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity. These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway epithelial cells and macrophages. Thus, allergic airway inflammation represents an antifungal defensive strategy that is driven by fibrinogen cleavage and TLR4 activation. These findings clarify the molecular basis of allergic disease and suggest new therapeutic strategies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898200/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898200/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millien, Valentine Ongeri -- Lu, Wen -- Shaw, Joanne -- Yuan, Xiaoyi -- Mak, Garbo -- Roberts, Luz -- Song, Li-Zhen -- Knight, J Morgan -- Creighton, Chad J -- Luong, Amber -- Kheradmand, Farrah -- Corry, David B -- AI057696/AI/NIAID NIH HHS/ -- AI070973/AI/NIAID NIH HHS/ -- CA125123/CA/NCI NIH HHS/ -- HL75243/HL/NHLBI NIH HHS/ -- K02 HL075243/HL/NHLBI NIH HHS/ -- R01 AI057696/AI/NIAID NIH HHS/ -- R01 HL095382/HL/NHLBI NIH HHS/ -- R01 HL117181/HL/NHLBI NIH HHS/ -- R25GM56929/GM/NIGMS NIH HHS/ -- T32 GM088129/GM/NIGMS NIH HHS/ -- T32GM088129/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):792-6. doi: 10.1126/science.1240342.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspergillus niger/growth & development/*immunology ; Aspergillus oryzae/enzymology ; Bronchoalveolar Lavage Fluid/cytology ; Epithelial Cells/immunology/metabolism ; Fibrinogen/*metabolism ; Immunity, Innate ; Ligands ; Macrophage Activation ; Macrophages/immunology/metabolism/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Peptide Hydrolases/immunology/*metabolism ; Respiratory Hypersensitivity/*immunology/*metabolism ; Respiratory Mucosa/cytology/immunology/metabolism ; Th2 Cells/immunology ; Toll-Like Receptor 4/genetics/*metabolism
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    Science & SciLifeLab Prize. From persistence to cross-species emergence of a viral zoonosis (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streicker, Daniel G -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1185-6. doi: 10.1126/science.1247566.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biodiversity, Animal Health, and Comparative Medicine, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Awards and Prizes ; Chiroptera/genetics/*virology ; Climate ; *Communicable Diseases, Emerging/transmission ; Evolution, Molecular ; History, 21st Century ; Host-Pathogen Interactions ; Rabies/prevention & control/*transmission/*veterinary ; Rabies virus/*genetics/pathogenicity ; Species Specificity ; United States ; *Zoonoses/prevention & control
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The annual meeting: improving what isn't broken (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Oct 4;342(6154):74-9. doi: 10.1126/science.342.6154.74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24092731" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Congresses as Topic/*economics/*trends ; United States
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    C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-21
    Description: The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. However, the International Knockout Mouse Consortium uses an embryonic stem cell line derived from a related C57BL/6N substrain. We found that C57BL/6N has a lower acute and sensitized response to cocaine and methamphetamine. We mapped a single causative locus and identified a nonsynonymous mutation of serine to phenylalanine (S968F) in Cytoplasmic FMRP interacting protein 2 (Cyfip2) as the causative variant. The S968F mutation destabilizes CYFIP2, and deletion of the C57BL/6N mutant allele leads to acute and sensitized cocaine-response phenotypes. We propose that CYFIP2 is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500108/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500108/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kumar, Vivek -- Kim, Kyungin -- Joseph, Chryshanthi -- Kourrich, Said -- Yoo, Seung-Hee -- Huang, Hung Chung -- Vitaterna, Martha H -- de Villena, Fernando Pardo-Manuel -- Churchill, Gary -- Bonci, Antonello -- Takahashi, Joseph S -- F32 DA024556/DA/NIDA NIH HHS/ -- F32DA024556/DA/NIDA NIH HHS/ -- U01 MH061915/MH/NIMH NIH HHS/ -- U01MH61915/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1508-12. doi: 10.1126/science.1245503.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357318" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Central Nervous System Stimulants/administration & dosage ; Cocaine/*administration & dosage ; Cocaine-Related Disorders/*genetics/*psychology ; *Drug-Seeking Behavior ; Methamphetamine/administration & dosage ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/drug effects ; Mutation ; Nerve Tissue Proteins/genetics/*physiology ; Phenylalanine/genetics ; Polymorphism, Single Nucleotide ; Psychomotor Performance/drug effects ; Quantitative Trait Loci ; Serine/genetics
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    Social science. Senator's demands freeze NSF political science grants (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):703. doi: 10.1126/science.341.6147.703.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950505" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government/legislation & jurisprudence ; *Politics ; Research ; Research Support as Topic/*legislation & jurisprudence ; United States ; *United States Government Agencies/economics/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Europe. Drug watchdog ponders how to open clinical trial data vault (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabesandratana, Tania -- New York, N.Y. -- Science. 2013 Mar 22;339(6126):1369-70. doi: 10.1126/science.339.6126.1369.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23520086" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Clinical Trials as Topic ; Confidentiality ; Drug Approval ; *Drug Industry ; Europe ; Information Dissemination ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Glutamate-dependent neuroglial calcium signaling differs between young and adult brain (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: An extensive literature shows that astrocytes exhibit metabotropic glutamate receptor 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic transmission and, in turn, modulate neuronal activity by their Ca(2+)-dependent release of gliotransmitters. These findings, based on studies of young rodents, have led to the concept of the tripartite synapse, in which astrocytes actively participate in neurotransmission. Using genomic analysis, immunoelectron microscopy, and two-photon microscopy of astrocytic Ca(2+) signaling in vivo, we found that astrocytic expression of mGluR5 is developmentally regulated and is undetectable after postnatal week 3. In contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages. Neuroglial signaling in the adult brain may therefore occur in a manner fundamentally distinct from that exhibited during development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Wei -- McConnell, Evan -- Pare, Jean-Francois -- Xu, Qiwu -- Chen, Michael -- Peng, Weiguo -- Lovatt, Ditte -- Han, Xiaoning -- Smith, Yoland -- Nedergaard, Maiken -- NS075177/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- P51OD011132/OD/NIH HHS/ -- P51RR000165/RR/NCRR NIH HHS/ -- R01 NS075177/NS/NINDS NIH HHS/ -- R01 NS078167/NS/NINDS NIH HHS/ -- R01 NS078304/NS/NINDS NIH HHS/ -- RR00165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):197-200. doi: 10.1126/science.1226740.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307741" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Aging ; Animals ; Astrocytes/*metabolism ; Calcium/metabolism ; *Calcium Signaling ; Cerebral Cortex/cytology/*metabolism/ultrastructure ; Female ; Glutamic Acid/*metabolism ; Hippocampus/cytology/metabolism/ultrastructure ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/agonists/*metabolism ; Synaptic Transmission
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    How long can the U.S. stay on top? (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1394-9. doi: 10.1126/science.340.6139.1394.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23788778" target="_blank"〉PubMed〈/a〉
    Keywords: Financial Management ; Financing, Government ; Foundations ; *Fund Raising ; *Research Support as Topic ; United States ; Universities/*economics/*standards
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    Epidemiology. Report reignites battle over low-salt diets (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2013 May 24;340(6135):908. doi: 10.1126/science.340.6135.908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704540" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans ; Blood Pressure ; Cardiovascular Diseases/*epidemiology ; Diet, Sodium-Restricted/adverse effects/*standards ; *Health Planning Guidelines ; Humans ; Sodium, Dietary/administration & dosage/blood ; United States
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    Genetics. Moving beyond "isolated" gene patents (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-03
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807680/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807680/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rai, Arti K -- Cook-Deegan, Robert -- P50 HG003391/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2013 Jul 12;341(6142):137-8. doi: 10.1126/science.1242217. Epub 2013 Jun 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University School of Law, Durham, NC 27708, USA. rai@law.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23811224" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Complementary/genetics ; Exons ; *Genes ; Genes, BRCA1 ; Genes, BRCA2 ; Genetics/*legislation & jurisprudence ; Humans ; Introns ; Patents as Topic/*legislation & jurisprudence ; Supreme Court Decisions ; United States
    Print ISSN: 0036-8075
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    Science and regulation. Probiotics: finding the right regulatory balance (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffmann, D E -- Fraser, C M -- Palumbo, F B -- Ravel, J -- Rothenberg, K -- Rowthorn, V -- Schwartz, J -- R01 HG005171/HG/NHGRI NIH HHS/ -- R01-HG005171/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):314-5. doi: 10.1126/science.1244656.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Maryland School of Law, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136953" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials, Phase I as Topic/standards ; Consumer Health Information/standards ; Dietary Supplements/adverse effects/standards ; *Government Regulation ; Humans ; Investigational New Drug Application ; Microbiota/physiology ; Probiotics/adverse effects/*standards ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Creating a false memory in the hippocampus (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-28
    Description: Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramirez, Steve -- Liu, Xu -- Lin, Pei-Ann -- Suh, Junghyup -- Pignatelli, Michele -- Redondo, Roger L -- Ryan, Tomas J -- Tonegawa, Susumu -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jul 26;341(6144):387-91. doi: 10.1126/science.1239073.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN-Massachusetts Institute of Technology Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology, MIT, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23888038" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/physiology ; Animals ; Association ; CA1 Region, Hippocampal/cytology/*physiology ; *Conditioning (Psychology) ; Dentate Gyrus/cytology/*physiology ; Dependovirus/genetics ; Doxycycline/administration & dosage ; Fear ; Genes, fos ; Light ; Memory/*physiology ; Mental Recall/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/*physiology ; Optogenetics ; Rhodopsin/genetics/metabolism
    Print ISSN: 0036-8075
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    Predators in the 'hood (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, Virginia -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1332-5. doi: 10.1126/science.341.6152.1332.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052284" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Biota ; *Conservation of Natural Resources ; Coyotes ; Endangered Species ; *Food Chain ; Geese ; Humans ; Population ; *Predatory Behavior ; Puma ; United States ; Ursidae ; Wolves
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    Seize the neuroscience moment (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leshner, Alan I -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):533. doi: 10.1126/science.1247343.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alan I. Leshner is the chief executive officer of AAAS and executive publisher of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179188" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/trends ; Brain/*physiology ; Capital Financing ; Humans ; Neurosciences/economics/*trends ; United States
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    Maintaining science eminence (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leshner, Alan I -- New York, N.Y. -- Science. 2013 Aug 23;341(6148):820. doi: 10.1126/science.1244269.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23970668" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*economics ; *Budgets ; Science/*economics ; United States ; United States Government Agencies/economics
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    Funding innovative science (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Anthony A -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):119. doi: 10.1126/science.1234741.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307707" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; Financing, Government ; Inventions ; National Institutes of Health (U.S.)/*economics ; *Research ; *Research Support as Topic ; United States
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    Cell Biology. NIH effort gambles on mysterious extracellular RNAs (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):947. doi: 10.1126/science.341.6149.947.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990535" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; *Disease ; Financing, Organized ; Government Programs/*economics ; Humans ; National Institutes of Health (U.S.) ; RNA/*physiology ; United States
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    betaCaMKII in lateral habenula mediates core symptoms of depression (2013)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2013-08-31
    Description: The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression. However, the molecular mechanism by which LHb becomes hyperactive in depression remains unknown. Through a quantitative proteomic screen, we found that expression of the beta form of calcium/calmodulin-dependent protein kinase type II (betaCaMKappaIotaIota) was significantly up-regulated in the LHb of animal models of depression and down-regulated by antidepressants. Increasing beta-, but not alpha-, CaMKII in the LHb strongly enhanced the synaptic efficacy and spike output of LHb neurons and was sufficient to produce profound depressive symptoms, including anhedonia and behavioral despair. Down-regulation of betaCaMKII levels, blocking its activity or its target molecule the glutamate receptor GluR1 reversed the depressive symptoms. These results identify betaCaMKII as a powerful regulator of LHb neuron function and a key molecular determinant of depression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932364/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932364/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Kun -- Zhou, Tao -- Liao, Lujian -- Yang, Zhongfei -- Wong, Catherine -- Henn, Fritz -- Malinow, Roberto -- Yates, John R 3rd -- Hu, Hailan -- P41 GM103533/GM/NIGMS NIH HHS/ -- R01 MH067880/MH/NIMH NIH HHS/ -- R01 MH091119/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):1016-20. doi: 10.1126/science.1240729.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990563" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & ; inhibitors/*biosynthesis/genetics ; Depressive Disorder, Major/*enzymology/genetics/psychology ; Disease Models, Animal ; Gene Knockdown Techniques ; Habenula/drug effects/*enzymology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects/enzymology ; Promoter Regions, Genetic ; Proteomics ; Rats ; Rats, Sprague-Dawley
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    Retrospective. Fred Sherman (1932-2013) (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liebman, Susan W -- Haber, James E -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1059. doi: 10.1126/science.1248055.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Illinois at Chicago, Chicago, IL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288325" target="_blank"〉PubMed〈/a〉
    Keywords: Genetics/*history ; History, 20th Century ; History, 21st Century ; Saccharomyces cerevisiae/*genetics ; United States
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    Prizes. Molecule and market studies capture Nobel laurels (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):298-9. doi: 10.1126/science.342.6156.298.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136942" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemistry ; Computer Simulation/*history ; History, 20th Century ; History, 21st Century ; *Models, Chemical ; *Nobel Prize ; Proteins/chemistry/*history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Time to deal with antibiotics (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):777. doi: 10.1126/science.1248056.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Donald Kennedy is president emeritus at Stanford University, Stanford, CA, and a former editor-in-chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24233692" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/administration & dosage/*adverse effects/therapeutic use ; Antibiotic Prophylaxis/*adverse effects/*veterinary ; Centers for Disease Control and Prevention (U.S.) ; Chickens ; Chlortetracycline/administration & dosage/adverse effects/therapeutic use ; Communicable Diseases/drug therapy/epidemiology/veterinary ; *Drug Resistance, Bacterial ; *Guidelines as Topic ; Humans ; *Legislation, Veterinary ; Penicillins/administration & dosage/adverse effects/therapeutic use ; Swine ; Tetracycline/administration & dosage/adverse effects/therapeutic use ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Environmental policy. House subpoena revives battle over air pollution studies (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Servick, Kelly -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):604. doi: 10.1126/science.341.6146.604.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929961" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/*prevention & control ; Conservation of Natural Resources/*legislation & jurisprudence ; *Environmental Policy ; Federal Government ; Humans ; Lung Neoplasms/*mortality ; Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    An important anniversary (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cicerone, Ralph J -- New York, N.Y. -- Science. 2013 Apr 12;340(6129):119. doi: 10.1126/science.1238209.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23580494" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; History, 21st Century ; *National Academy of Sciences (U.S.)/history/organization & administration ; Public Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    The many ways of making academic research pay off (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):750-3. doi: 10.1126/science.339.6121.750.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23413332" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/*economics ; Commerce/*economics ; Egypt ; Government Programs ; Laboratories/economics ; Research/*economics ; *Technology Transfer ; United States ; Universities/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Avian influenza. H5N1 researchers ready as moratorium nears end (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2013 Jan 4;339(6115):16-7. doi: 10.1126/science.339.6115.16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23288516" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/economics/*standards ; Birds ; *Guidelines as Topic ; *Influenza A Virus, H5N1 Subtype ; Influenza in Birds/*virology ; National Institutes of Health (U.S.)/economics/standards ; *Policy ; Security Measures/*standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-28
    Description: A dense mucus layer in the large intestine prevents inflammation by shielding the underlying epithelium from luminal bacteria and food antigens. This mucus barrier is organized around the hyperglycosylated mucin MUC2. Here we show that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs). Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcgammaRIIB receptor complex that activated beta-catenin. This transcription factor interfered with DC expression of inflammatory but not tolerogenic cytokines by inhibiting gene transcription through nuclear factor kappaB. MUC2 induced additional conditioning signals in intestinal epithelial cells. Thus, mucus does not merely form a nonspecific physical barrier, but also constrains the immunogenicity of gut antigens by delivering tolerogenic signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005805/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005805/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shan, Meimei -- Gentile, Maurizio -- Yeiser, John R -- Walland, A Cooper -- Bornstein, Victor U -- Chen, Kang -- He, Bing -- Cassis, Linda -- Bigas, Anna -- Cols, Montserrat -- Comerma, Laura -- Huang, Bihui -- Blander, J Magarian -- Xiong, Huabao -- Mayer, Lloyd -- Berin, Cecilia -- Augenlicht, Leonard H -- Velcich, Anna -- Cerutti, Andrea -- AI073899/AI/NIAID NIH HHS/ -- AI095245/AI/NIAID NIH HHS/ -- AI57653/AI/NIAID NIH HHS/ -- AI61093/AI/NIAID NIH HHS/ -- AI74378/AI/NIAID NIH HHS/ -- AI95613/AI/NIAID NIH HHS/ -- AI96187/AI/NIAID NIH HHS/ -- DK072201/DK/NIDDK NIH HHS/ -- P01 AI061093/AI/NIAID NIH HHS/ -- P01 DK072201/DK/NIDDK NIH HHS/ -- P60 DK020541/DK/NIDDK NIH HHS/ -- R01 AI057653/AI/NIAID NIH HHS/ -- R01 AI093577/AI/NIAID NIH HHS/ -- U01 AI095613/AI/NIAID NIH HHS/ -- U19 AI096187/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 25;342(6157):447-53. doi: 10.1126/science.1237910. Epub 2013 Sep 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072822" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Dendritic Cells/immunology ; Galectin 3/genetics/metabolism ; Glycosylation ; *Homeostasis ; Humans ; Immune Tolerance/genetics/*immunology ; Inflammation/immunology ; Intestinal Mucosa/immunology ; Intestine, Small/*immunology ; Lectins, C-Type/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mouth/*immunology ; Mucin-2/genetics/physiology ; Mucus/*immunology ; NF-kappa B/metabolism ; Receptors, IgG/genetics/metabolism ; Transcription, Genetic ; beta Catenin/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-19
    Description: Environmental stressors during childhood and adolescence influence postnatal brain maturation and human behavioral patterns in adulthood. Accordingly, excess stressors result in adult-onset neuropsychiatric disorders. We describe an underlying mechanism in which glucocorticoids link adolescent stressors to epigenetic controls in neurons. In a mouse model of this phenomenon, a mild isolation stress affects the mesocortical projection of dopaminergic neurons in which DNA hypermethylation of the tyrosine hydroxylase gene is elicited, but only when combined with a relevant genetic risk for neuropsychiatric disorders. These molecular changes are associated with several neurochemical and behavioral deficits that occur in this mouse model, all of which are blocked by a glucocorticoid receptor antagonist. The biology and phenotypes of the mouse models resemble those of psychotic depression, a common and debilitating psychiatric disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617477/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617477/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niwa, Minae -- Jaaro-Peled, Hanna -- Tankou, Stephanie -- Seshadri, Saurav -- Hikida, Takatoshi -- Matsumoto, Yurie -- Cascella, Nicola G -- Kano, Shin-ichi -- Ozaki, Norio -- Nabeshima, Toshitaka -- Sawa, Akira -- K99 MH094408/MH/NIMH NIH HHS/ -- K99MH-094408/MH/NIMH NIH HHS/ -- MH-069853/MH/NIMH NIH HHS/ -- MH-084018/MH/NIMH NIH HHS/ -- MH-085226/MH/NIMH NIH HHS/ -- MH-088753/MH/NIMH NIH HHS/ -- MH-092443/MH/NIMH NIH HHS/ -- MH-094268/MH/NIMH NIH HHS/ -- R01 MH092443/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):335-9. doi: 10.1126/science.1226931.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Pharmacology, Meijo University Graduate School of Pharmaceutical Sciences, Nagoya, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329051" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Adolescent Behavior ; *Adolescent Development ; Affective Disorders, Psychotic/genetics/*metabolism ; Animals ; Disease Models, Animal ; Dopaminergic Neurons/*metabolism ; *Epigenesis, Genetic ; Glucocorticoids/*metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nerve Tissue Proteins/genetics/metabolism ; Stress, Psychological/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Strategy behind science policy decisions (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Juliano, Rudy -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):430. doi: 10.1126/science.340.6131.430-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620036" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiology ; Humans ; Neurosciences/*economics ; *Policy Making ; Research/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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