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  • United States  (56)
  • Rabbits  (23)
  • American Association for the Advancement of Science (AAAS)  (79)
  • American Chemical Society
  • American Geophysical Union
  • Periodicals Archive Online (PAO)
  • 1980-1984  (79)
  • 1925-1929
  • 1983  (79)
Collection
Keywords
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  • American Association for the Advancement of Science (AAAS)  (79)
  • American Chemical Society
  • American Geophysical Union
  • Periodicals Archive Online (PAO)
  • Springer  (1)
Years
  • 1980-1984  (79)
  • 1925-1929
Year
  • 1
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    Fluorides and dental caries (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Apr 8;220(4593):142, 144, 146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828887" target="_blank"〉PubMed〈/a〉
    Keywords: Dental Caries/*prevention & control ; *Fluoridation ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Law and science policy in federal regulation of formaldehyde (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: An examination of the way in which the Environmental Protection Agency, Occupational Safety and Health Administration, and Consumer Product Safety Commission each responded to evidence of formaldehyde's carcinogenicity in animal systems reveals the interplay between politics and science policy in regulatory determinations. In some cases there were significant and unjustified departures from reasoned decision-making. Agency decisions not to take action deserve special attention by citizens, the Congress, and the judiciary to ensure that federal regulatory agencies take the necessary steps to protect the public from significant health, safety, and environmental risks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ashford, N A -- Ryan, C W -- Caldart, C C -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):894-900.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635664" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Consumer Product Safety ; Environmental Exposure ; Formaldehyde/*adverse effects ; Jurisprudence ; *Public Policy ; United States ; United States Environmental Protection Agency ; United States Occupational Safety and Health Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Organ donation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capron, Alexander M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644013" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; Humans ; Mandatory Programs ; *Public Policy ; *Tissue Donors ; *Tissue and Organ Procurement ; United States ; Voluntary Programs
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Advertising prescription drugs (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charrow, R P -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857235" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/*legislation & jurisprudence ; Drug Industry ; *Drug Prescriptions ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Congress passes generous NIH budget. An increase above 10 percent spares NIH unpalatable cuts in grants, programs, and payment of indirect costs (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):483-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623085" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.) ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Gordon Battelle (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fawcett, S L -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):707.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6348943" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; Research/*history ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Information technology (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-11
    Description: The AAAS Annual Meeting will be held in Detroit on 26-31 May 1983. The inclusive dates were given incorrectly as 21-31 May in the heading of the Preliminary Program (25 Feb., p. 948). The large body of water shown to the south of Detroit on the cover of the issue of 25 February is Lake Erie. The cover legend stated incorrectly that it was Lake Huron.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, C M -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1172.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828850" target="_blank"〉PubMed〈/a〉
    Keywords: *Information Systems ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Government intercedes in "Baby Jane Doe" (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6227081" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Multiple ; Civil Rights ; *Disabled Persons ; Federal Government ; Female ; *Government Regulation ; Humans ; Infant, Newborn ; *Judicial Role ; *Jurisprudence ; United States ; *Withholding Treatment ; Department of Justice suit in November 1983 against the State University Hospital ; in Stony Brook, New York, to obtain the infant's medical records. Parents and ; physicians had decided against treatment for the severely handicapped newborn, ; but legal action was begun by right-to-life advocates to appoint a guardian for ; the child and to order surgery. The Department of Justice became involved after ; two New York courts ruled against the action ; the Department's intervention is ; based on Section 504 of the Rehabilitation Act, which forbids discrimination ; against the handicapped.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Insanity defense reexamined. The AMA board recommends its abolition but lawyers and psychiatrists say that would undermine the moral basis of criminal law (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):994-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648520" target="_blank"〉PubMed〈/a〉
    Keywords: American Medical Association ; *Forensic Psychiatry ; Humans ; *Mental Disorders ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    HHS preparing to issue new Baby Doe rules (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1269-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612339" target="_blank"〉PubMed〈/a〉
    Keywords: Child Advocacy/legislation & jurisprudence ; *Congenital Abnormalities ; Ethics Committees, Clinical ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; United States ; *United States Dept. of Health and Human Services ; Withholding Treatment ; the Department of Health and Human Services is preparing a second version of ; federal rules designed to ensure appropriate treatment of handicapped newborns ; with life-threatening but correctible conditions. While child advocacy groups ; support the regulations with some reservations about the intrusive style of ; enforcement, most medical organizations, led by the American Academy of ; Pediatrics, are strongly opposed. Both houses of Congress have become involved ; with the issue by proposing to include handicapped infants under the Child Abuse ; and Treatment Act.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Residential radiological standards (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurwitz, H Jr -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1377.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828868" target="_blank"〉PubMed〈/a〉
    Keywords: *Housing ; Humans ; *Radiation ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Protein phosphatases: properties and role in cellular regulation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingebritsen, T S -- Cohen, P -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):331-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cyclic AMP/metabolism ; Glycogen/metabolism ; Liver/enzymology ; Muscles/enzymology ; Phosphoprotein Phosphatases/classification/*physiology ; Phosphoproteins/metabolism ; Phosphorylase Phosphatase/metabolism ; Phosphorylation ; Protein Biosynthesis ; Protein Kinases/physiology ; Rabbits ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 15
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    Funding more NIH research grants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: Because of the prospect of a serious decline in the nation's biomedical research capacity owing to diminished federal appropriations, temporary measures should be initiated promptly by the National Institutes of Health to preserve the stability of resources and diversity of research required for future productivity. It is recommended that the available funds be distributed in such a way as to permit some support for 50 percent of competing grant applications approved by the National Institutes of Health study sections. Measures proposed for consideration are a sliding scale for funding, a greater across-the-board reduction, a limit on support for an individual laboratory, and a review of indirect costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867712" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.)/organization & administration ; *Research Support as Topic/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 16
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    Deadlock over explosive dust (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):485-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623087" target="_blank"〉PubMed〈/a〉
    Keywords: Accidents, Occupational/*prevention & control ; *Agriculture ; *Dust ; *Edible Grain ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Acquired immune deficiency syndrome abroad. The new immune deficiency disease is now found in several countries: links to Central Africa and Haiti may provide clues to its origin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):998-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648521" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/transmission ; Africa, Central ; Blood ; Europe ; Female ; Haiti ; Homosexuality ; Humans ; Male ; Sarcoma, Kaposi/epidemiology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Oxygen tension regulates the expression of angiogenesis factor by macrophages (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knighton, D R -- Hunt, T K -- Scheuenstuhl, H -- Halliday, B J -- Werb, Z -- Banda, M J -- GM27345/GM/NIGMS NIH HHS/ -- HL26323/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612342" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents/*biosynthesis ; Animals ; Anoxia/physiopathology ; Cells, Cultured ; Cornea ; Growth Substances/*biosynthesis ; Macrophages/*physiology ; Models, Biological ; Oxygen/*physiology ; Rabbits ; *Wound Healing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Cholesterol--heart disease link illuminated. New findings explain how blood cholesterol levels are controlled and how to lower them substantially in persons at high risk of heart disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1164-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310747" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticholesteremic Agents/therapeutic use ; Cholesterol/*blood ; Coronary Disease/drug therapy/*etiology ; Humans ; Lovastatin ; Naphthalenes/therapeutic use ; Rabbits ; Receptors, Cell Surface/physiology ; Receptors, LDL
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Bone cell differentiation and growth factors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urist, M R -- DeLange, R J -- Finerman, G A -- DEO2103-17/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):680-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development ; Bone Matrix/drug effects/physiology ; Bone Morphogenetic Proteins ; Bone Neoplasms/physiopathology ; Cattle ; Cell Differentiation ; DNA, Neoplasm/metabolism ; Dogs ; Growth Substances/*physiology ; Guinea Pigs ; Haplorhini ; Humans ; Insulin-Like Growth Factor II ; Mice ; *Osteogenesis ; Osteosarcoma/physiopathology ; Proteins/pharmacology/physiology ; Rabbits ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Health rights issue emerges in El Salvador (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, John -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1047-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643956" target="_blank"〉PubMed〈/a〉
    Keywords: *Delivery of Health Care ; Education, Medical ; El Salvador ; Financial Support ; Health Personnel ; *Human Rights ; Humans ; Organizational Policy ; Physicians ; Politics ; *Professional Misconduct ; Public Policy ; *Societies ; United States ; Violence ; Salvador in January as observers for the American Association for the Advancement ; of Science, the National Academy of Sciences, the New York Academy of Sciences, ; and the International League for Human Rights. Their findings paralleled those of ; an earlier delegation--"a virtually complete breakdown of the health system" and ; continuing violence against health professionals. A number of scientific ; organizations in the U.S. are reported to be exploring ways to channel private ; aid from health professionals and to protect the rights of patients and health ; personnel without antagonizing the government of El Salvador.
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    Cost-effective priorities for cancer prevention (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: Faced with limited resources, the United States must set priorities for research to identify preventable causes of cancer. A quantitative approach to priority setting, based on principles of decision analysis and cost-effectiveness analysis, can offer guidance in this process. An illustrative application of such a model suggests that the National Institutes of Health-supported clinical trial of dietary beta-carotene offers a greater expected reduction in cancer mortality per research dollar than carcinogen bioassays of high-volume industrial chemicals such as p-dichlorobenzene. National research priorities should reflect the relative cost-effectiveness of such investments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, M C -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):17-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6407110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Carcinogens ; Carotenoids/adverse effects ; Chlorobenzenes/adverse effects ; Cost-Benefit Analysis ; Costs and Cost Analysis ; Humans ; Neoplasms/economics/mortality/*prevention & control ; Policy Making ; United States ; beta Carotene
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  • 23
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    Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-14
    Description: 5 beta-Dihydrocortisol potentiated the threshold level (the smallest dose producing a measurable effect) of topically applied cortisol (0.02 percent) and dexamethasone (0.003 percent) in causing nuclear translocation of the cytosolic glucocorticoid receptor in rabbit iris-ciliary body tissue. 5 beta-Dihydrocortisol accumulates in cells cultured from trabecular meshwork specimens from patients with primary open-angle glaucoma, but not in similar cells derived from nonglaucomatous patients. In view of the sensitivity of patients with primary open-angle glaucoma to the effects of glucocorticoids in raising intraocular pressure, this potentiation may be responsible for the steroid sensitivity and for the ocular hypertension seen in this disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, B I -- Gordon, G G -- Southren, A L -- EY 01313/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):172-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623065" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/metabolism ; Ciliary Body/metabolism ; Cytoplasm/metabolism ; Dexamethasone/pharmacology ; Glaucoma, Open-Angle/*physiopathology ; Hydrocortisone/pharmacology ; Intraocular Pressure/*drug effects ; Iris/metabolism ; Rabbits ; Receptors, Glucocorticoid/*drug effects/metabolism ; Receptors, Steroid/*drug effects
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  • 24
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    Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-28
    Description: Fluorinated anesthetics were observed noninvasively in the brain of intact rabbits with fluorine-19 nuclear magnetic resonance spectroscopy. High-resolution fluorine-19 spectra of halothane, methoxyflurane, and isoflurane were obtained with a surface coil centered over the calvarium. Elimination of halothane from the brain was also monitored by this technique. Residual fluorine-19 signals from halothane (or a metabolite) could be detected as long as 98 hours after termination of anesthesia. These observations demonstrate the feasibility of using this technique to study the fate of fluorinated anesthetics in live mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyrwicz, A M -- Pszenny, M H -- Schofield, J C -- Tillman, P C -- Gordon, R E -- Martin, P A -- GM 29520/GM/NIGMS NIH HHS/ -- K04 GM 00503/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):428-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623084" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Halothane/*metabolism ; Isoflurane/*metabolism ; Kinetics ; Magnetic Resonance Spectroscopy ; Methoxyflurane/*metabolism ; Methyl Ethers/*metabolism ; Rabbits
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    AMA's technology assessment (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sammons, J H -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1375-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828867" target="_blank"〉PubMed〈/a〉
    Keywords: *American Medical Association ; Humans ; Medical Laboratory Science/*standards ; United States
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  • 26
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 27
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    Science, risk, and public policy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: A climate of fear now dominates the discussion of environmental issues. The scientific community can help alleviate this fear by making a greater effort to explain to the public the uncertainties involved in estimates of risk. Current statutory mandates designed to protect public health both demand levels of protection that technology cannot achieve and are uncoordinated across government agencies. A common statutory framework for dealing with environmental risks is needed. In addition, care must be taken to separate the scientific process of assessing risk from the use of such assessments, together with economic and policy considerations, in the management of risks through regulatory action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruckelshaus, W D -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879200" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Pollutants ; International Cooperation ; Legislation as Topic ; *Public Policy ; Risk ; *Science ; United States ; United States Environmental Protection Agency
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  • 28
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    Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Hippocampal ablation has no effect on the acquisition of the rabbit's classically conditioned nictitating membrane response. Systemic administration of scopolamine, which alters hippocampal neuronal activity, severely retards acquisition of the conditioned response in normal animals and those with cortical ablations. In animals with hippocampal ablations, however, scopolamine has no effect on conditioning. These findings suggest that altered neuronal activity in the hippocampus is more detrimental to conditioning than removing the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Solomon, P R -- Solomon, S D -- Schaaf, E V -- Perry, H E -- MH33381/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836277" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning, Classical/drug effects/*physiology ; Female ; Hippocampus/drug effects/*physiology ; Male ; Nictitating Membrane/physiology ; Rabbits ; Scopolamine Hydrobromide/pharmacology
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  • 29
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    Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. Measurements of the ouabain-sensitive QO2 in the presence of nystatin, the tissue sodium and potassium contents of the tubules in suspension, and the sodium- and potassium-dependent adenosinetriphosphatase (Na,K-ATPase) activity of lysed tubule membranes indicated that the effect of amiloride was due to a direct inhibition of the Na,K-ATPase activity of the proximal tubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soltoff, S P -- Mandel, L J -- AM26816/AM/NIADDK NIH HHS/ -- GM29256/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302840" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Ion Channels/drug effects ; Kidney Tubules, Proximal/drug effects/*enzymology ; Nystatin/pharmacology ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Pyrazines/*pharmacology ; Rabbits ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors/metabolism
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    Study says U.S. drug firms falling behind. But academy study contrasts with earlier findings by OTA that the drug industry is healthy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1157-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612327" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Industry ; Evaluation Studies as Topic ; Patents as Topic ; Research ; United States
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  • 31
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-08
    Description: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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  • 32
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    Running and breathing in mammals (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-21
    Description: Mechanical constraints appear to require that locomotion and breathing be synchronized in running mammals. Phase locking of limb and respiratory frequency has now been recorded during treadmill running in jackrabbits and during locomotion on solid ground in dogs, horses, and humans. Quadrupedal species normally synchronize the locomotor and respiratory cycles at a constant ratio of 1:1 (strides per breath) in both the trot and gallop. Human runners differ from quadrupeds in that while running they employ several phase-locked patterns (4:1, 3:1, 2:1, 1:1, 5:2, and 3:2), although a 2:1 coupling ratio appears to be favored. Even though the evolution of bipedal gait has reduced the mechanical constraints on respiration in man, thereby permitting greater flexibility in breathing pattern, it has seemingly not eliminated the need for the synchronization of respiration and body motion during sustained running. Flying birds have independently achieved phase-locked locomotor and respiratory cycles. This hints that strict locomotor-respiratory coupling may be a vital factor in the sustained aerobic exercise of endothermic vertebrates, especially those in which the stresses of locomotion tend to deform the thoracic complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bramble, D M -- Carrier, D R -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):251-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849136" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gait ; Horses ; Humans ; *Locomotion ; Mammals ; *Physical Exertion ; Rabbits ; *Respiration
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    Uphill sodium transport driven by an inward calcium gradient in heart muscle (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-14
    Description: Heart cells were loaded with sodium by treatment with toxic doses of acetyl strophanthidin. After this treatment, an increase in extracellular calcium resulted in a transient net outward sodium flux against its electrochemical gradient and in net cellular uptake of calcium. It is concluded that the free energy for the net outward sodium movement was derived from the increased calcium gradient and that these ion movements took place through the sodium-calcium exchange. While in the normal physiological state the sodium-calcium exchange produces calcium extrusion from the cell, these experiments demonstrate its reversibility.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521047/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521047/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridge, J H -- Bassingthwaighte, J B -- P41 RR001243/RR/NCRR NIH HHS/ -- P41 RR001243-190021/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849128" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Calcium/*metabolism ; Cytoplasm/metabolism ; Membrane Potentials ; Myocardium/*metabolism ; Potassium/metabolism ; Rabbits ; Sarcolemma/metabolism ; Sodium/*metabolism
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    Coping with fraud: the Darsee Case (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):31-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828878" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; Federal Government ; *Fraud ; *National Institutes of Health (U.S.) ; Research ; Schools, Medical ; United States ; Medical School, from the first known act of fraud to recent evidence that ; implicates Darsee's earlier work at Emory University and Notre Dame. Darsee's ; Harvard data were eventually re-examined both by Harvard and by a panel appointed ; by the National Heart, Lung, and Blood Institute (NHLBI), which had funded much ; of his research. The NHLBI findings, which were reviewed by senior staff at the ; National Institutes of Health, faulted the supervisory practices of Darsee's ; mentor, Dr. Eugene Braunwald. Braunwald acknowledges the need for change but ; believes that his pattern of supervision is common to many laboratories.
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    Wyngaarden sets policy agenda for NIH (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):470-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687409" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Research Support as Topic ; Training Support ; United States
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  • 36
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    The two faces of genetic engineering in man (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, B D -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1381.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6572417" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Behavior Control ; *Ethics, Medical ; *Genetic Engineering ; Humans ; Religion ; United States
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  • 37
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    Shark cartilage contains inhibitors of tumor angiogenesis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-16
    Description: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, A -- Langer, R -- EY04002/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6193581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cartilage/*physiology ; Cell Line ; Cornea ; Neoplasms/*blood supply ; *Neovascularization, Pathologic ; Rabbits ; Sharks
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  • 38
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    Turnover, membrane insertion, and degradation of sodium channels in rabbit urinary bladder (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: Noise analysis of rabbit bladder revealed two components: Lorentzian noise, arising from interaction of amiloride with the Na+ channel, and flicker noise (l/f, where f is frequency), as in other biological membranes. Hydrostatic pressure, which causes exchange between intracellular vesicular membrane and apical membrane, increases the number but not the single-channel current of the amiloride-sensitive channels. Flicker noise arises from degraded channels that have lost amiloride sensitivity and Na+ to K+ selectivity. The degraded channels were selectively removed by washing the mucosal surface. These results imply channel turnover by intracellular synthesis, transfer from vesicular to apical membrane, degradation, and elimination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loo, D D -- Lewis, S A -- Ifshin, M S -- Diamond, J M -- AM17327/AM/NIADDK NIH HHS/ -- AM20851/AM/NIADDK NIH HHS/ -- GM14772/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612343" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/pharmacology ; Animals ; Cell Membrane/metabolism ; Cytoplasmic Granules/metabolism ; Epithelium/physiology ; Rabbits ; Sodium/*metabolism ; Urinary Bladder/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Revisions in cancer policy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828879" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Dioxins/adverse effects ; *Government Agencies ; Humans ; Policy Making ; Trichloroethylene/adverse effects ; United States ; *United States Environmental Protection Agency
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    Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: Centrally administered alpha-melanocyte stimulating hormone is much more potent in reducing fever than the widely used antipyretic acetaminophen. This finding supports the hypothesis that the endogenous neuropeptide has a role in the limitation of fever and suggests that it may be clinically useful as an antipyretic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, M T -- Richards, D B -- Lipton, J M -- NS 10046/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):192-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602381" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/*pharmacology ; Body Temperature/drug effects ; Dose-Response Relationship, Drug ; Fever/drug therapy ; Humans ; Melanocyte-Stimulating Hormones/*pharmacology ; Rabbits
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cancer chemotherapy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cairns, J -- Boyle, D -- Frei, E 3rd -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):252, 254, 256.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836271" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Antineoplastic Agents/*therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Leukemia/drug therapy/mortality ; Male ; Neoplasms/*drug therapy/mortality ; United States
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    Cotton dust standard (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frumin, E -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):340.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687371" target="_blank"〉PubMed〈/a〉
    Keywords: *Dust ; Environmental Exposure ; Gossypium ; United States ; United States Occupational Safety and Health Administration
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    EPA faults classic lead poisoning study. A review questions a study linking lead in teeth with low IQ scores; EPA finds other grounds for regulation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):906-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6688887" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Humans ; *Intelligence ; Lead/analysis ; Lead Poisoning/*complications ; Tooth/analysis ; United States ; United States Environmental Protection Agency
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Entamoeba histolytica causes intestinal secretion: role of serotonin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: Lysates of the protozoan parasite Entamoeba histolytica altered active electrolyte transport when present on the serosal surface of rabbit ileum and rat colon. The lysate-induced effects on electrolyte transport were similar to those caused by serotonin, and were blocked by bufotenine, an analog known to inhibit the action of serotonin. The transport effects were partially inhibited by antibody to serotonin. The amebic lysates were shown to contain serotonin by radioimmunoassay, high-performance liquid chromatography, and thin-layer chromatography. These results suggest that the serotonin present in Entamoeba histolytica may be important in the diarrhea seen in amebiasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGowan, K -- Kane, A -- Asarkof, N -- Wicks, J -- Guerina, V -- Kellum, J -- Baron, S -- Gintzler, A R -- Donowitz, M -- AM26523/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):762-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308760" target="_blank"〉PubMed〈/a〉
    Keywords: Amebiasis/*physiopathology ; Animals ; Biological Transport ; Colon/physiopathology ; Diarrhea/physiopathology ; Disease Models, Animal ; Entamoeba histolytica/*physiology ; Entamoebiasis/*physiopathology ; Ileum/physiopathology ; Intestinal Absorption ; Rabbits ; Rats ; Serotonin/*physiology
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    Congress, NIH open coffers for AIDS (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):436, 438.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867719" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Female ; Humans ; Male ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    Liver transplants endorsed. An NIH consensus panel recommends more transplants but does not say who will pay (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344219" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Humans ; *Liver Transplantation ; National Institutes of Health (U.S.) ; Patient Selection ; Tissue and Organ Procurement ; United States ; Liver Transplantation has concluded that, with some exceptions, transplantation ; could be considered for most patients who are near death with liver disease. This ; recommendation comes despite problems in interpreting existing data on survival ; rates. The panel did not address the issues of who should pay for liver ; transplants, or of how many donor livers would be needed if more transplantation ; centers were established.
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    Organ shortage clouds new transplant era (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857260" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Death ; Female ; Humans ; Male ; Mandatory Programs ; Middle Aged ; Tissue Donors ; *Tissue and Organ Procurement ; *Transplantation ; United States ; tissue are revolutionizing organ transplantation, but the current shortage of ; donated organs is expected to worsen. The reasons for this shortage and possible ; solutions to the problem are discussed briefly, and the ethical and legal ; implications of salvaging organs from brain-dead patients are mentioned. Presumed ; consent laws, already in force in several European countries, would drastically ; increase the number of available organs, but American ethicists are divided over ; a policy permitting automatic use of organs unless a person has left explicit ; instructions to the contrary.
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    Prescription drug ads put FDA on the spot (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):387-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836280" target="_blank"〉PubMed〈/a〉
    Keywords: *Advertising as Topic/legislation & jurisprudence ; Drug Prescriptions ; Federal Government ; *Government Regulation ; Humans ; Information Dissemination ; *Pharmaceutical Preparations ; Risk Assessment ; United States ; *United States Food and Drug Administration ; companies would like to be allowed to advertise their prescription drugs to the ; general public as well as to health professionals. The Food and Drug ; Administration, concerned about the legal and ethical implications of ; direct-to-consumer advertising, has asked for time to study the proposal.
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    Incidence of strokes declines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 May 6;220(4597):591.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836302" target="_blank"〉PubMed〈/a〉
    Keywords: Cerebrovascular Disorders/*epidemiology/prevention & control ; Humans ; Hypertension/prevention & control ; United States
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    Reagan's budget boosts basic research (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Feb 11;219(4585):747-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823551" target="_blank"〉PubMed〈/a〉
    Keywords: *Research Support as Topic ; United States
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    A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Gal alpha (1 leads to 3)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nudelman, E -- Kannagi, R -- Hakomori, S -- Parsons, M -- Lipinski, M -- Wiels, J -- Fellous, M -- Tursz, T -- CA 19224/CA/NCI NIH HHS/ -- CA 20026/CA/NCI NIH HHS/ -- GM 23100/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836295" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Antigens, Neoplasm/*immunology ; Burkitt Lymphoma/*immunology ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/immunology ; Globosides/*immunology ; Glycosphingolipids/*immunology ; Humans ; Rabbits ; Rats ; *Trihexosylceramides
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    Ground water contamination in the United States (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: Ground water contamination is of increasing concern in the United States because about 50 percent of our drinking water comes from well water. The causes of contamination stem from both point sources and nonpoint sources. Since ground water moves slowly, the contaminant may affect only a small portion of an aquifer for a considerable period of time. Deleterious effects on human health have resulted from pathogenic organisms in ground water and from its toxic chemical composition. It is difficult to estimate the extent of contamination on a national basis as the frequency of instances of contamination is very variable. Remedial actions to clean up aquifers are difficult, expensive, and sometimes not feasible. Many of the laws and regulations that control ground water contamination are designed with other main objectives.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pye, V I -- Patrick, R -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):713-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879171" target="_blank"〉PubMed〈/a〉
    Keywords: Ecology ; United States ; United States Environmental Protection Agency ; Water Pollution/*analysis
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    Human leukocyte functions and the U.S. safety standard for exposure to radio-frequency radiation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Human mononuclear leukocytes were exposed to microwaves at energies relevant to current public safety recommendations. No detectable effects on viability or function of the leukocytes resulted from exposure to microwaves at specific absorption rates up to 4 milliwatts per milliliter. The results were highly reproducible and provided no evidence that current safety standard recommendations are inappropriate insofar as leukocyte function is concerned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, N J Jr -- Lu, S T -- Michaelson, S M -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):318-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6188214" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/biosynthesis ; Environmental Exposure ; Humans ; Leukocytes/*radiation effects ; Maximum Allowable Concentration ; Protein Biosynthesis ; RNA/biosynthesis ; Radio Waves/*adverse effects ; United States
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    Carcinogen policy at EPA (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Feb 18;219(4586):794, 796, 798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823552" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; United States ; United States Environmental Protection Agency
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    Alcoholism studies (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barlow, D H -- Bellack, A S -- Buchwald, A M -- Garfield, S L -- Hartmann, D P -- Herman, C P -- Hersen, M -- Miller, P M -- Rachman, S -- Wolpe, J -- New York, N.Y. -- Science. 1983 May 6;220(4597):554, 556.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836301" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*therapy ; *Behavioral Research ; Canada ; *Editorial Policies ; *Ethics, Medical ; Humans ; United States
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    Sex differences in mathematical reasoning ability: more facts (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: Almost 40,000 selected seventh-grade students from the Middle Atlantic region of the United States took the College Board Scholastic Aptitude Test as part of the Johns Hopkins regional talent search in 1980, 1981, and 1982. A separate nationwide talent search was conducted in which any student under age 13 who was willing to take the test was eligible. The results obtained by both procedures establish that by age 13 a large sex difference in mathematical reasoning ability exists and that it is especially pronounced at the high end of the distribution: among students who scored greater than or equal to 700, boys outnumbered girls 13 to 1. Some hypothesized explanations of such differences were not supported by the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benbow, C P -- Stanley, J C -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648516" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Cognition ; Female ; Humans ; Male ; *Mathematics ; Sex Factors ; United States
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    Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas: novel suppressor mechanism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dick, S J -- Macchi, B -- Papazoglou, S -- Oldfield, E H -- Kornblith, P L -- Smith, B H -- Gately, M K -- New York, N.Y. -- Science. 1983 May 13;220(4598):739-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6220469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cytotoxicity, Immunologic ; Glioma/immunology/*metabolism ; Glycosaminoglycans/biosynthesis ; Humans ; Hyaluronoglucosaminidase/metabolism ; Immunity, Cellular ; Lymphocytes/immunology/*metabolism ; Mice ; Rabbits
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    Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Folkman, J -- Langer, R -- Linhardt, R J -- Haudenschild, C -- Taylor, S -- EY04002/EY/NEI NIH HHS/ -- GM25810/GM/NIGMS NIH HHS/ -- R01-CA14019/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):719-25.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6192498" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Chick Embryo ; Cortisone/*pharmacology ; Heparin/*pharmacology ; Inflammation ; Neoplasm Metastasis ; Neoplasms, Experimental/blood supply ; Neovascularization, Pathologic/*physiopathology ; Oligosaccharides/pharmacology ; Rabbits ; Structure-Activity Relationship
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    "Baby Doe" regs thrown out by court (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):479-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836291" target="_blank"〉PubMed〈/a〉
    Keywords: Congenital Abnormalities/therapy ; *Euthanasia ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; Judicial Role ; Parental Consent ; United States ; *United States Dept. of Health and Human Services ; *Withholding Treatment ; as "arbitrary and capricious," a Department of Health and Human Services ; regulation that required hospitals to post notices concerning the illegality of ; denying life-saving care to handicapped infants and encouraged anyone with ; knowledge of such a case to report it to HHS via a telephone hotline. This ; article reviews the evolution and implementation of the HHS regulation, the legal ; challenge to it, and the judge's ruling.
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    NIH seeks reduction in "indirect costs" (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):929-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879191" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; Universities/economics
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    A nursing institute for NIH? (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1310-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658453" target="_blank"〉PubMed〈/a〉
    Keywords: *Legislation, Nursing ; *National Institutes of Health (U.S.) ; *Nursing ; Research ; United States
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    NIH pays a price for "stability" (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):243-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857283" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.)/organization & administration ; Research Support as Topic ; United States
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    Emory reports on Darsee's fraud (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 May 27;220(4600):936.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844919" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Fraud ; Georgia ; Humans ; National Institutes of Health (U.S.) ; Research ; United States ; he was appointed a fellow at the Harvard Medical School, has revealed fabrication ; of data, unauthorized use of co-authors' names, and fictitious collaborators. The ; Emory investigation was undertaken after Harvard notified Emory of its suspicion ; of Darsee's Harvard research. Emory's investigative report focused only on the ; extent of Darsee's data fabrication. A copy of the report was sent immediately to ; the National Institutes of Health, but the university was reluctant to send it to ; medical licensing boards or to the hospital where Darsee is currently employed.
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    Memories are made of this (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6140756" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior ; Behavior, Animal ; Brain/*physiology ; Haplorhini ; Humans ; Memory/*physiology ; Neurotransmitter Agents/physiology ; Rabbits
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    The murky world of toxicity testing (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1130-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857237" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Crime ; *Fraud ; Illinois ; Mice ; Pesticides/toxicity ; Rats ; *Toxicology ; United States ; United States Environmental Protection Agency
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    Nestle letter stops NIH talk (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):469.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687408" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Ethics ; *Federal Government ; *Infant Food ; *National Institutes of Health (U.S.) ; United States ; discussion of a dispute on the marketing of infant formula from a symposium on ; bioethics because of protests by the Nestle Company. NIH administrators deny that ; censorship was the reason for the cancellation.
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    Suppression of epididymal sperm antigenicity in the rabbit by uteroglobin and transglutaminase in vitro (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-25
    Description: There is evidence that the mammalian female genital tract is capable of responding immunologically when challenged with alloantigens. The antigenic properties of male gametes have been well delineated. However, it is only rarely that a female mammal ever responds immunologically to the male gametic antigens as a result of coitus. When a proposed mechanism of suppression of antigenicity of epididymal spermatozoa was tested experimentally, the results indicated that two proteins (uteroglobin and transglutaminase) present in the prostate may be responsible for suppressing sperm antigenicity in the rabbit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukherjee, D C -- Agrawal, A K -- Manjunath, R -- Mukherjee, A B -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):989-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6130601" target="_blank"〉PubMed〈/a〉
    Keywords: Acyltransferases/*immunology/metabolism ; Animals ; Epididymis/immunology ; Female ; Glycoproteins/*immunology ; *Immune Tolerance ; Lymphocyte Activation ; Male ; Rabbits ; Semen/enzymology/*immunology ; Spermatozoa/*immunology ; Transglutaminases ; Uteroglobin/*immunology
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    Clerics urge ban on altering germline cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574603" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Cell Line ; *Ethics, Medical ; Federal Government ; Genetic Diseases, Inborn/therapy ; *Genetic Engineering ; *Germ Cells ; *Government Regulation ; Human Characteristics ; Humans ; Risk Assessment ; United States ; cells has been signed by leaders of almost every major church group in the United ; States. Some of the religious leaders, while not certain that a total moratorium ; should be placed on altering germline cells, signed the statement in order to ; stimulate public debate on the issue. Legislation has recently been introduced in ; Congress to set up a committee to monitor genetic engineering and its human ; applications, but author Jeremy Rifkin, the impetus behind the church leaders' ; resolution, argues that such tampering threatens the gene pool and should be ; banned altogether.
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    Congress reprieves a lab (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):484.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623086" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.) ; Research Support as Topic/*legislation & jurisprudence ; United States
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    NIH bill passes house. Legislators strike a middle ground by adding some new programs, but not as many as Waxman wanted (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):992-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648519" target="_blank"〉PubMed〈/a〉
    Keywords: *Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; Research ; United States
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    A push for animal welfare bills (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):633.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Dogs ; Goats ; Haplorhini ; *Legislation as Topic ; National Institutes of Health (U.S.) ; Swine ; United States
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    FDA draws criticism on prenatal test (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):440-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867721" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; Female ; *Government Regulation ; Humans ; Neural Tube Defects/*diagnosis ; Pregnancy ; Pregnant Women ; *Prenatal Diagnosis/instrumentation ; Risk Assessment ; United States ; United States Food and Drug Administration ; Administration on 17 June to approve the wider use of diagnostic kits for the ; detection of fetal neural tube defects. The American College of Obstetricians and ; Gynecologists and the American Academy of Pediatrics are among the critics who ; favor tighter restrictions on use of the kits, which measure levels of ; alpha-fetoprotein in serum samples taken from expectant mothers, on the grounds ; that false positive results are common, necessitating careful quality control ; monitoring of physicians, manufacturers, and laboratories performing the test.
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    A new chairman for Senate science panel (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1407.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828869" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Politics ; Research Support as Topic ; *Science ; United States
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    Fishing for a forum on health policy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):37-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849113" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Health Policy ; United States ; country without any comprehensive, nonpartisan forum for assessing the safety and ; cost effectiveness of biomedical technologies. While many private and public ; groups found the Center's evaluations useful, the American Medical Association ; and the Health Industry Manufacturers Association viewed it as a regulatory ; agency and lobbied for its closure. Despite the efforts of various medical ; societies, insurers, and the medical device industry to establish their own ; review programs, many policy analysts would like to see a federal panel revived.
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    Wide world of reports. ABC objections to linkage of aggression to TV violence in NIMH report brings social scientists into contention in novel public skirmish (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1983 May 20;220(4599):804-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844916" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*psychology ; Child ; Humans ; National Institute of Mental Health (U.S.) ; *Television ; United States ; *Violence
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    Normalization of depressed heart function in rats by ribose (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-01
    Description: Severe constriction of the abdominal aorta and simultaneous injection of isoproterenol in rats induced depression in heart function and reductions in cardiac adenosine triphosphate and total adenine nucleotides. When ribose was continuously infused for 24 hours, biosynthesis of cardiac adenine nucleotides was stimulated to such an extent that the reductions in adenosine triphosphate and total adenine nucleotides were prevented and left ventricular hemodynamic parameters were normal. These results support the hypothesis that adenosine triphosphate is primarily responsible for depression in myocardial contractility and that ribose is cardioprotective through its pronounced effects on adenine nucleotide metabolism in heart muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimmer, H G -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):81-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6402820" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/biosynthesis/metabolism ; Adenosine Triphosphate/physiology ; Animals ; Aorta, Abdominal/physiology ; Heart/drug effects/physiology ; Isoproterenol/pharmacology ; Myocardial Contraction/*drug effects ; Myocardium/metabolism ; Rabbits ; Rats ; Ribose/*pharmacology
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    Biogen pays high price for Harvard patent (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6581535" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; Genetic Engineering/*methods ; *Patents as Topic ; United States ; powerful gene-splicing technique to Biogen, whose chairman, Walter Gilbert, ; developed the process while at the university. Although Biogen has invested ; heavily in the gene-splicing technique and is confident it will replace or ; successfully compete with methods currently used to manufacture human insulin and ; other proteins, some experts question whether Gilbert's process is commercially ; feasible.
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    The drug industry nearly won last year, but then the political winds changed (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):593-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635657" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Industry ; Legislation as Topic ; *Patents as Topic ; United States
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    Knapp reinterprets excellence at NSF (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):990-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6359415" target="_blank"〉PubMed〈/a〉
    Keywords: *Foundations ; History, 20th Century ; Research Support as Topic ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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