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  • Mice  (90)
  • Cells, Cultured  (45)
  • Rats, Inbred Strains  (20)
  • American Association for the Advancement of Science (AAAS)  (138)
  • 1980-1984  (138)
  • 1982  (138)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (138)
  • Springer  (2)
Years
  • 1980-1984  (138)
Year
  • 1
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    Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Gastric acid secretion has been thought to depend on histamine stimulation of the parietal cell. However, in the 2-week-old rat neither exogenous histamine nor the H-2 receptor agonist impromidine stimulates acid secretion, whereas pentagastrin and the cholinergic agent bethanechol are potent stimuli. At this age, the effect of pentagastrin in acid secretion is not blocked by the H-2 receptor antagonist cimetidine, nor is it potentiated by impromidine. These data suggest that, in the rat pup, the acid secretory response to pentagastrin and cholinergic agents occurs before the histamine-mediated system is functional and operates independently of the actions of histamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackerman, S H -- K1-MH00077/MH/NIMH NIH HHS/ -- R01-AM-18804/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211765" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bethanechol Compounds/pharmacology ; Gastric Juice/drug effects/*secretion ; Gastric Mucosa/growth & development ; Guanidines/pharmacology ; Histamine/pharmacology ; Imidazoles/pharmacology ; Impromidine ; Pentagastrin/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Histamine H2/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Female athymic nude mice and their phenotypically normal littermates were exposed transplacentally to ethylnitrosourea. Skin tumors (papillomas and sebaceous adenomas) developed on the nude mice with an almost tenfold greater incidence than on their haired littermates. Skin tumors were also induced on nude mice but not haired controls by direct intraperitoneal treatment with ethylnitrosourea. These results indicate that nude mice have higher than normal susceptibility to carcinogenesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, L M -- Last-Barney, K -- Budinger, J M -- CA 08748/CA/NCI NIH HHS/ -- CA 22498/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):682-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134965" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/chemically induced ; Animals ; *Ethylnitrosourea ; Female ; *Maternal-Fetal Exchange ; Mice ; Mice, Nude/*physiology ; Neoplasms, Experimental/chemically induced ; *Nitrosourea Compounds ; Pregnancy ; Sebaceous Gland Neoplasms/chemically induced ; Skin Neoplasms/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Mice regrow the tips of their foretoes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Mice will replace the tip of a foretoe when it is amputated distal to the last interphalangeal joint. Amputation of the digit more proximal to the joint does not result in regrowth of the foretoe. Though this growth shares certain similarities with the epimorphic regeneration of amphibian limbs, the two processes are not the same. The regrowth reported here in mice is probably similar to the scattered clinical reports of fingertips regeneration in children, and presents a model system with which to explore the controls of wound healing and tissue reconstruction in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borgens, R B -- CA 20920/CA/NCI NIH HHS/ -- NS 18456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):747-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100922" target="_blank"〉PubMed〈/a〉
    Keywords: Amputation ; Animals ; Child ; Humans ; Mice ; Mice, Inbred C3H ; *Regeneration ; Toe Joint ; Toes/anatomy & histology/*physiology ; Wound Healing
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: (+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their behavioral effects on squirrel monkeys and rats trained to discriminate phencyclidine from saline. Dose-response determinations were made for responses to phencyclidine, to a racemic mixture of N-allylnormetazocine, and to the pure levo and dextro isomers of N-allylnormetazocine. In both rats and monkeys, the dextro isomer and the racemic mixture produced dose-dependent responses appropriate for phencyclidine; the levo isomer did not produce the responses appropriate for phencyclidine at any of the doses tested. In both species, the levo isomer was more potent than the dextro isomer in decreasing the rate of responding. Thus racemic N-allylnormetazocine is a mixture of compounds that produce different behavioral effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brady, K T -- Balster, R L -- May, E L -- DA-00490/DA/NIDA NIH HHS/ -- DA-01442/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274022" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Male ; Naloxone/pharmacology ; Phenazocine/*analogs & derivatives/pharmacology ; Phencyclidine/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid/drug effects ; Saimiri ; Stereoisomerism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. These findings suggest that the normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridges, R S -- Grimm, C T -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Drug Antagonism ; Female ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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  • 7
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    Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-06
    Description: Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bump, E A -- Yu, N Y -- Brown, J M -- CA-15201/CA/NCI NIH HHS/ -- CM-87207/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):544-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089580" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anoxia ; Cell Survival/drug effects/*radiation effects ; Cells, Cultured ; Cricetinae ; Cricetulus ; Drug Synergism ; Glutathione/*metabolism ; Maleates/administration & dosage ; Mice ; Mice, Inbred BALB C ; Misonidazole/administration & dosage ; Neoplasms, Experimental/metabolism ; *Oxygen Consumption
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Deficiency of functional messenger RNA for a developmentally regulated beta-crystallin polypeptide in a hereditary cataract (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: The messenger RNA for a beta-crystallin polypeptide with a molecular size of 27 kilodaltons, first detected 5 to 10 days after birth in the normal mouse lens and the Nakano mouse cataract, was not detected in the Philly mouse cataract with translation in vitro. The heterozygous Philly lens had intermediate levels of the 27-kilodalton beta-crystallin polypeptide and exhibited delayed onset of the cataract. The deficiency of functional 27-kilodalton beta-crystallin messenger RNA is the earliest lesion reported yet for the Philly lens and points to a transcriptional or posttranscriptional developmental defect in this hereditary cataract.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carper, D -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):463-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178163" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cataract/*genetics ; Cell-Free System ; Crosses, Genetic ; Crystallins/*genetics ; Mice ; Mice, Inbred Strains ; Protein Biosynthesis ; Proteins ; RNA/genetics ; RNA Splicing ; RNA, Messenger/*genetics
    Print ISSN: 0036-8075
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  • 9
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    Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: The electrophysiological effects of ethanol in low doses (5 to 20 millimoles per liter or 23 to 92 milligrams per 100 milliliters) were examined intracellularly in CA1 cells of rat hippocampus in vitro. Inhibitory and excitatory postsynaptic potentials were increased when ethanol was applied to the respective synaptic terminal regions. Postsynaptically, ethanol caused a moderate hyperpolarization with increased membrane conductance, even when synaptic transmission was blocked. Ethanol augmented the hyperpolarization that followed repetitive firing or that followed the eliciting of calcium spikes in the presence of tetrodotoxin, but not the rapid afterhyperpolarization in calcium-free medium. Ethanol appears to augment calcium-mediated mechanisms both pre- and postsynaptically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Gurevich, N -- Durand, D -- R01 NS16660-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Electric Conductivity ; Ethanol/*pharmacology ; Hippocampus/*drug effects/physiology ; Male ; Membrane Potentials/drug effects ; Potassium/physiology ; Rats ; Rats, Inbred Strains ; Synaptic Membranes/drug effects ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Development of mouse embryos in vitro: preimplantation to the limb bud stage (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Mouse embryos were grown successfully in vitro from the blastocyst stage to the limb bud stage. Mouse blastocysts grown in vitro for 10 days showed blood circulation in the yilk sac, forelimb buds, and the primordia of liver, pancreas, and lungs. These characteristics are indicative of a developmental stage equivalent to one-half of the total gestation period in utero. Improvements in culture conditions from days 7 to 9 have made it feasible to culture mouse blastocysts beyond the early somite stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L T -- Hsu, Y C -- AM 19535/AM/NIADDK NIH HHS/ -- AM 28550/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*physiology ; Cell Differentiation ; Culture Media ; Culture Techniques ; Embryo, Mammalian/*physiology ; Female ; Fetal Blood ; Humans ; Mice ; Pregnancy ; Yolk Sac/physiology
    Print ISSN: 0036-8075
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  • 11
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    In vitro Evidence for two distinct hippocampal growth factors: basis of neuronal plasticity? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: The rat hippocampal formation was tested for the presence of factors that would accelerate neurite extension from chick parasympathetic (ciliary ganglion) or sympathetic (lumbar chain) neurons in vitro. Two growth factors were identified in extracts of this brain region. One accelerated neurite extension from sympathetic neurons and was blocked by antiserum to nerve growth factor. The other accelerated neurite extension from parasympathetic neurons but was not affected by the antiserum. These results suggest that specific growth factors account for the specificity of neuronal sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crutcher, K A -- Collins, F -- NS 17131/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):67-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089542" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Cells, Cultured ; Chick Embryo ; Ganglia, Parasympathetic/physiology ; Ganglia, Sympathetic/physiology ; Growth Substances/*physiology ; Hippocampus/*physiology ; Neurons/*physiology
    Print ISSN: 0036-8075
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  • 12
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    Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Receptors for maleylated or acetylated proteins as well as for alpha-2-macroglobulin-protease complexes on macrophages serve as scavengers by mediating the uptake of macromolecules from the extracellular compartment. Described in this report is a novel function of these receptors on macrophages: regulation of neutral protease secretion. The binding of maleylated bovine serum albumin to macrophages triggered secretion of three neutral proteases: neutral caseinases, plasminogen activator, and cytolytic proteinase. Release of acid phosphatase, however, was not induced. An important biological consequence of protease secretion by macrophages, tumor-cytolysis, was also triggered by engagement of the receptor for maleylated bovine serum albumin. By contrast, the binding of alpha-2-macroglobulin-protease complexes to the macrophages suppressed secretion of all three proteases. Thus two receptors heretofore believed to serve principally as scavengers also regulate secretory functions of macrophages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, W J -- Pizzo, S V -- Imber, M J -- Adams, D O -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):574-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289443" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Glycoproteins/*metabolism ; Macrophages/*enzymology ; *Metalloendopeptidases ; Mice ; Peptide Hydrolases/*secretion ; Plasminogen Activators/secretion ; Receptors, Cell Surface/*physiology
    Print ISSN: 0036-8075
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  • 13
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 14
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    Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, R D -- Proudfit, H K -- Yeung, S M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):58-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123218" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/administration & dosage/*analogs & derivatives/pharmacology ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Apomorphine/pharmacology ; Caudate Nucleus/*physiology ; Corpus Striatum/*physiology ; Dopamine/*physiology ; Injections ; Kinetics ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Rotation ; Vasodilator Agents/*pharmacology
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  • 15
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    alpha A-crystallin messenger RNA of the mouse lens: more noncoding than coding sequences (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: The 14S messenger RNA (1300 to 1500 nucleotides) for the alpha A chain of alpha-crystallin of the mammalian lens is nearly three times larger than required to code for the polypeptide that contains 173 amino acids. As a means of accounting for this anomaly, a complementary DNA clone for the mouse alpha A-crystallin messenger RNA was constructed in pBR322 and sequenced. Derivation of the protein sequence from the nucleic acid sequence showed that mouse alpha A-crystallin is similar to that of other organisms. The messenger RNA contains 536 nucleotides located on the 3' side of the coding region, excluding the polyadenylate stretch. This 3' sequence does not encode any other crystallin and has multiple termination codons in the three possible reading frames.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, C R -- Shinohara, T -- Piatigorsky, J -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7156978" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; Crystallins/*genetics ; Mice ; RNA, Messenger/*genetics
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  • 16
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    Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, N W -- Plenefisch, J D -- Carey, S W -- Fredrickson, W T -- Sackett, G P -- Burbacher, T M -- Parker, R M -- HD02774/HD/NICHD NIH HHS/ -- HD08633/HD/NICHD NIH HHS/ -- RR00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053560" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/*blood ; Animals ; Congenital Abnormalities/*etiology ; Ectogenesis ; Female ; Macaca nemestrina/blood ; Mice ; Pregnancy ; Rats
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  • 17
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    Brain receptors for appetite discovered (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):460-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123243" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamines ; Animals ; Appetite/*physiology ; Brain/*physiology ; *Carrier Proteins ; Mice ; Receptors, Adrenergic/*physiology
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  • 18
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    Purinergic regulation of food intake (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, A S -- Morley, J E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Deoxyguanosine/pharmacology ; Diazepam/pharmacology ; Eating/*drug effects ; Food Deprivation ; Inosine/analogs & derivatives/pharmacology ; Insulin/pharmacology ; Male ; Muscimol/pharmacology ; Purines/*pharmacology ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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  • 19
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    Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Cyclic adenosine monophosphate (AMP) analogs or agents that increase intracellular cyclic AMP rapidly stimulate transcription of the prolactin gene in a line of cultured rat pituitary cells. This effect is correlated with the phosphorylation of a chromatin-associated basic protein designated BPR. These data are consistent with the postulate that increased intracellular cyclic AMP concentrations induce rapid transcriptional effects on specific genes in eukaryotes, mediated by direct or indirect phosphorylation of a specific chromatin-associated protein or proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murdoch, G H -- Rosenfeld, M G -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293056" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromatin/*metabolism ; Cyclic AMP/analogs & derivatives/*metabolism ; Nucleoproteins/metabolism ; Phosphorylation ; Pituitary Gland/metabolism ; Prolactin/genetics ; Rats ; *Transcription, Genetic
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  • 20
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    Actin distribution patterns in the mouse neural tube during neurulation (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: With the use of antibodies to actin and indirect immunofluorescent techniques regions of increased actin concentration were demonstrated first in basal and later in apical areas of mouse neuroepithelial cells. These patterns of staining corresponded to shape changes observed in cranial neural folds as they initially elevated from the neural plate and later moved toward the midline.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sadler, T W -- Greenberg, D -- Coughlin, P -- Lessard, J L -- HD-12295/HD/NICHD NIH HHS/ -- HD-14220/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):172-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031898" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Brain/embryology ; Cytoskeleton/*ultrastructure ; Fluorescent Antibody Technique ; Mice ; Morphogenesis ; Nervous System/*embryology/ultrastructure
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  • 21
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    Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nekola, M B -- Horvath, A -- Ge, L J -- Coy, D H -- Schally, A V -- HD-0-2831/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):160-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750790" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Female ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/secretion ; Ovulation/*drug effects ; Pregnancy ; Proestrus/drug effects ; Rats ; Rats, Inbred Strains
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Tumor metastasis is not due to adaptation of cells to a new organ environment (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: Murine B16 melanoma cells were adapted for lung survival and growth by allowing them to attach to Bio-Carrier beads and injecting the beads intravenously into normal mice. The beads lodged mechanically in the microcirculation of the lung. When the melanoma cells had grown into visible tumors from the arrested beads, the tumors were removed and the cells were dispersed, cultured to remove normal cells, and reattached to new beads. The process was repeated nine times. Previously another B16 subline was injected intravenously as a suspension of separate tumor cells. Those cells that survived and colonized the lungs were harvested, cultured, and injected again. This selection process was also repeated nine times. Only the subline that was injected in suspension was more metastatic than the parental line, indicating that metastasis involves selection of preexistent metastatic cells and is not an adaptive process by which all cells gradually acquire the ability to grow at particular organ sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicolson, G L -- Custead, S E -- R01-CA28867/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):176-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Lung Neoplasms/pathology/*secondary ; Melanoma/*pathology ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/pathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Increased axonal proteolysis in myelin-deficient mutant mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-19
    Description: Protein degradation within retinal ganglion cell axons in vitro is 50 to 110 percent faster than normal in mutant mice exhibiting deficiencies of myelin in the central nervous system. Proteolysis is increased proximally and distally within retinal ganglion cell axons of mice carrying the jumpy mutation or its allele, myelin synthesis deficiency, and is increased distally within those axons of quaking mice. The proteolytic defect is axon (neuron)-specific since the rate of protein degradation within glial cells is normal. Increased axonal proteolysis does not bear a simple relation to hypomyelination since shiverer, another mouse mutant deficient in central myelin, displayed normal rates of axonal protein degradation under the same conditions. These observations suggest an abnormal axon-glial interaction in mice with primary glial defects and raise the possibility that the functioning of histologically normal axons (neurons) may be altered in dysmyelinating diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nixon, R A -- NS15494/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):999-1001.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7156980" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*metabolism ; Mice ; *Mice, Neurologic Mutants ; Neuroglia/metabolism ; Neurons ; Proteins/*metabolism ; Retina/cytology/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto-Sampedro, M -- Lewis, E R -- Cotman, C W -- Manthorpe, M -- Skaper, S D -- Barbin, G -- Longo, F M -- Varon, S -- AG-00538/AG/NIA NIH HHS/ -- MH-19691/MH/NIMH NIH HHS/ -- NS-16349/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):860-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100931" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/physiology ; Animals ; Brain/*physiology ; Brain Injuries/*physiopathology ; Cell Survival/drug effects ; Cells, Cultured ; Cholinergic Fibers/physiology ; Kinetics ; Nerve Growth Factors/*metabolism/pharmacology ; *Nerve Regeneration ; Rats ; Rats, Inbred Strains ; Wound Healing
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: The size of the gene pool potentially encoding antibodies to p-azophenyl arsonate has been examined. A heavy chain-specific full-length complementary DNA clone has been constructed with the use of messenger RNA from a hybridoma that produces antibodies to the arsonate hapten and bears nearly a full complement of the determinants comprising the cross-reactive idiotype (CRI). The sequences of both the complementary DNA clone and the corresponding immunoglobulin heavy chain have been independently determined. A probe for the variable region gene was prepared from the original heavy chain complementary DNA clone and used to analyze, by Southern filter hybridization, genomic DNA from both A/J (CRI positive) and BALB/c (CRI negative) mice. Approximately 20 to 25 restriction fragments containing "germline" variable region gene segments were detected in both strains, and many are shared by both, Since 35 CRI-positive heavy chains have been partially sequenced thus far and 31 are different, the results of the hybridization analysis suggest that somatic mutation events involving the variable region gene segments of the heavy chain play a role in the origin of the amino acid sequence diversity seen in this system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, J -- Rabbitts, T H -- Estess, P -- Slaughter, C -- Tucker, P W -- Capra, J D -- A112127/PHS HHS/ -- AI-06020/AI/NIAID NIH HHS/ -- AI18016/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801765" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites, Antibody/*genetics ; Genes ; Haptens ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Idiotypes/genetics ; Immunoglobulin Variable Region/*genetics ; Mice ; *Mutation
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  • 26
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    Evidence for the clonal origin of spontaneous metastases (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmadge, J E -- Wolman, S R -- Fidler, I J -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Aberrations ; Genetic Markers ; Karyotyping ; Lung Neoplasms/secondary ; Melanoma ; Mice ; Mice, Inbred C3H ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology
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  • 27
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    Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: alpha-Difluoromethylornithine is an enzyme-activated irreversible inhibitor of ornithine decarboxylase that forms a covalent bond with the enzyme. When alpha-[5-14C]difluoromethylornithine was administered to androgen-treated mice, only ornithine decarboxylase became labeled. Autoradiographic examination of kidney, liver, and brain indicated much more extensive incorporation of labeled difluoromethylornithine into kidney protein than into the protein of the other tissues. Such incorporation was greatly reduced by prior treatment of the mice with cycloheximide. These results correlate with the presence of ornithine decarboxylase activity which is much higher in the kidney than in the other tissues and is lost rapidly when protein synthesis is inhibited. The binding of this drug in vivo, therefore, is useful for determining the distribution of ornithine decarboxylase. The enzyme was predominantly located in the proximal tubule cells of the kidney in androgen-treated mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pegg, A E -- Seely, J -- Zagon, I S -- 1T32HL-07223/HL/NHLBI NIH HHS/ -- CA 18138/CA/NCI NIH HHS/ -- DA-01618/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):68-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806900" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain/enzymology ; Carbon Radioisotopes ; Carboxy-Lyases/*metabolism ; Eflornithine ; Kidney/drug effects/*enzymology ; Liver/enzymology ; Mice ; Organ Specificity ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*metabolism ; Ornithine Decarboxylase Inhibitors ; Testosterone/pharmacology
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  • 28
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    Transplantation of leukemic bone marrow treated with cytotoxic antileukemic antibodies and complement (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trigg, M E -- Poplack, D G -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046048" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; *Bone Marrow Transplantation ; Cell Survival ; *Complement System Proteins ; Cytotoxicity, Immunologic ; Female ; Leukemia L1210/*immunology/therapy ; Male ; Mice ; Mice, Inbred DBA
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  • 29
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    Proliferative capacity of murine hematopoietic stem cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-26
    Description: Large numbers of granulocytes can be collected repeatedly from the supernatant medium of long-term cultures of mouse bone marrow cells. A constant relationship was found between the number of adherent hematopoietic stem cells and the lifetime cell production per culture. The data indicate that there is a limit to the proliferative capacity of normal and of irradiated stem cells. A similar limitation was found in the production of marked granulocytes from clonal cultures of "beige" C57 (bg/bgJ) stem cells placed in limiting dilutions into stromal culture layers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reincke, U -- Hannon, E C -- Rosenblatt, M -- Hellman, S -- CA 10941/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1619-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071580" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Division/radiation effects ; Cells, Cultured ; Granulocytes/physiology ; *Hematopoiesis/radiation effects ; Hematopoietic Stem Cells/*cytology ; Mice ; Spleen/cytology
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  • 30
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    In vivo identification of the transforming gene product of simian sarcoma virus (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: Simian sarcoma virus (SSV) deletion mutants were constructed from a molecular clone containing the entire infectious provirus. Transfection analysis of these mutants localized the SSV transforming gene to a small region of the viral genome encompassing its cell-derived sequence (v-sis). Antiserum to a peptide synthesized on the basis of the predicted amino acid sequence of the SSV transforming gene detected a 28,000-dalton protein that was specifically expressed in SSV transformed cells and that corresponded in size to that predicted from the v-sis coding sequence. The v-sis gene product designated p28sis was not a phosphoprotein, nor did it possess detectable protein kinase activity. These findings distinguish p28sis from a number of other retroviral onc proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robbins, K C -- Devare, S G -- Reddy, E P -- Aaronson, S A -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1131-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293053" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral ; Base Sequence ; *Cell Transformation, Viral ; *Genes, Viral ; Mice ; Molecular Weight ; *Oncogenes ; Phosphoproteins/genetics ; Protein Kinases/genetics ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/*genetics ; Viral Proteins/*genetics/immunology
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  • 31
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    Hybridoma technology (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwaber, J -- New York, N.Y. -- Science. 1982 May 21;216(4548):798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7043734" target="_blank"〉PubMed〈/a〉
    Keywords: Allergy and Immunology/*history ; Animals ; History, 20th Century ; Hybridomas/*immunology ; Mice
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  • 32
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    Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-22
    Description: Gonadotropic activation of the adult rat testis in vitro and in vivo is followed by down-regulation of luteinizing hormone receptors and decreased androgen responses to subsequent hormonal stimulation. In contrast, treatment of cultured fetal testes with gonadotropins and dibutyryl adenosine 3',5'-monophosphate enhanced steroidogenic responsiveness and did not cause the luteinizing hormone-receptor loss and desensitization that is characteristic of the adult gonad. The analysis of gonadotropin receptors and action in cultured fetal testis cells facilitates developmental studies of gonadal function, and has revealed significant differences in the responses of fetal and adult Leydig cells to gonadotropic regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warren, D W -- Dufau, M L -- Catt, K J -- 1F33-HD06192/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):375-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289438" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bucladesine/pharmacology ; Cell Differentiation/drug effects ; Cells, Cultured ; Chorionic Gonadotropin/pharmacology ; Hydroxyprogesterones/biosynthesis ; Leydig Cells/*drug effects ; Luteinizing Hormone/pharmacology ; Male ; Progesterone/biosynthesis ; Rats ; Receptors, Cell Surface/*drug effects/metabolism ; Receptors, LH ; Testis/*embryology/metabolism ; Testosterone/biosynthesis
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    Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-21
    Description: Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiley, R G -- Blessing, W W -- Reis, D J -- HL07378/HL/NHLBI NIH HHS/ -- HL18974/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 21;216(4548):889-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177039" target="_blank"〉PubMed〈/a〉
    Keywords: *Abrin ; Animals ; *Axonal Transport ; *Lectins ; Mice ; Nerve Degeneration/drug effects ; Neurons/*drug effects ; *Plant Lectins ; *Plant Proteins ; Retrograde Degeneration ; Ribosome Inactivating Proteins, Type 2 ; *Ricin
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    Noise-induced hearing loss can alter neural coding and increase excitability in the central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: Responses of auditory neurons in the inferior colliculi of mice were studied longitudinally before and shortly after each animal was exposed to intense noise. Noise exposure caused expected losses in auditory sensitivity, but in 31 percent of the neurons studied, unexpected alterations of temporal patterns of action potentials were observed: certain suprathreshold stimuli that had evoked only transient "onset" responses or inhibition of spontaneous discharges prior to noise exposure came to elicit sustained excitation after exposure. Thus, noise-induced hearing loss can be associated with increases in neural responsivity and alterations of normal neural coding processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willott, J F -- Lu, S M -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1331-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079767" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Action Potentials ; Animals ; Evoked Potentials, Auditory ; Hearing Loss, Noise-Induced/*physiopathology ; Inferior Colliculi/*physiopathology ; Mice ; Mice, Inbred C57BL ; Neurons/*physiology
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    Recovery of olfactory function after bilateral bulbectomy (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-16
    Description: Mice were trained to discriminate between scented and unscented air. After olfactory bulbs were removed, discrimination was lost, but returned with the formation of synaptic connections between regenerated primary olfactory neurons and the cortex of the forebrain. The acquisition of a second olfactory-mediated task by long-term bulbectomized mice and controls was indistinguishable. The results emphasize the plasticity of the nervous system, correlate the presence of neural connections between olfactory mucosa and forebrain with the recovery of olfactory function, suggest that olfactory-mediated memory resides at least in part outside the olfactory bulbs, and demonstrate that the bulbs are not required for the acquisition of olfactory tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, J W -- Harding, J W -- NS 13976/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):322-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063891" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carnosine/physiology ; Central Nervous System/*physiology ; Female ; Memory/physiology ; Mice ; Neuronal Plasticity ; Olfactory Bulb/*physiology ; Olfactory Pathways/*physiology ; Smell/*physiology
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    Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-30
    Description: Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wysor, M S -- Zwelling, L A -- Sanders, J E -- Grenan, M M -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):454-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7201165" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cisplatin/adverse effects ; Disulfiram/*administration & dosage ; Kidney/pathology ; Male ; Mice ; Mice, Inbred ICR ; Necrosis/chemically induced ; Rats ; Sodium Chloride/administration & dosage ; Trypanosoma/drug effects ; Trypanosomiasis, African/pathology/*therapy
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    Wound tissue can utilize a polymeric template to synthesize a functional extension of skin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: Prompt and long-term closure of full-thickness skin wounds is guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yannas, I V -- Burke, J F -- Orgill, D P -- Skrabut, E M -- GM 21700/GM/NIGMS NIH HHS/ -- GM 23946/GM/NIGMS NIH HHS/ -- HL 14322/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031899" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Collagen/therapeutic use ; Female ; Glycosaminoglycans/therapeutic use ; Guinea Pigs ; Humans ; Male ; Middle Aged ; Silicone Elastomers/therapeutic use ; *Skin Transplantation ; *Wound Healing
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    Proton nuclear magnetic resonance of intact Friend leukemia cells: phosphorylcholine increase during differentiation (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: Proton nuclear magnetic resonance of intact Friend leukemia cells was used to analyze their erythroid-like differentiation. The technique, which requires only 10(3) to 10(9) cells and approximately 2 minutes for acquisition of each spectrum, demonstrated the occurrence of many signal changes during differentiation. With cell extracts, 64 signals were assigned to 12 amino acids and 19 other intermediary metabolites, and a dramatic signal change was attributed to a fourfold increase in cytoplasmic phosphorylcholines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agris, P F -- Campbell, I D -- 1-F33-GM07826/GM/NIGMS NIH HHS/ -- 1-FOG-TW00440/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Choline/*analogs & derivatives ; Kinetics ; Leukemia, Experimental/*physiopathology ; Magnetic Resonance Spectroscopy ; Mice ; Phosphorylcholine/*analysis
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
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    New method for detecting cellular transforming genes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: Tumor induction in athymic nude mice can be used to detect dominant transforming genes in cellular DNA. Mouse NIH 3T3 cells freshly transfected with either cloned Moloney sarcoma proviral DNA or cellular DNA's derived from virally transformed cells induced tumors when injected into athymic nu/nu mice. Tumors were also induced by cells transfected with DNA from two tumor-derived and one chemically transformed human cell lines. The mouse tumors induced by human cell line DNA's contained human DNA sequences, and DNA derived from these tumors was capable of inducing both tumors and foci on subsequent transfection. Tumor induction in nude mice represents a useful new method for the detection and selection of cells transformed by cellular oncogenes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blair, D G -- Cooper, C S -- Oskarsson, M K -- Eader, L A -- Vande Woude, G F -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1122-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293052" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Viral ; DNA, Neoplasm/*genetics ; DNA, Viral/genetics ; Mice ; Mice, Nude/*physiology ; Moloney murine leukemia virus/genetics ; Neoplasms, Experimental/*genetics ; *Oncogenes ; Sarcoma Viruses, Murine/genetics
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  • 41
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    Neurotoxin-specific immunoglobulins accelerate dissociation of the neurotoxin-acetylcholine receptor complex (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Toxin isolated from cobra venom and labeled with tritium was incubated with membranes rich in acetylcholine receptors. The amount of toxin bound to the receptors was determined and the kinetics of dissociation of the receptor-toxin complex was followed. Addition of an excess of horse antiserum to the venom resulted in a significant acceleration of the dissociation reaction. Similarly, a monoclonal antibody against the toxin accelerated dissociation of the receptor-toxin complex. The results indicate that specific antibody binding destabilizes the toxin-receptor complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boulain, J C -- Menez, A -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):732-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/physiology ; Cobra Neurotoxin Proteins/immunology/*metabolism ; Cobra Venoms/immunology/*metabolism ; Immunoglobulin Fab Fragments/physiology ; Immunoglobulins/*physiology ; In Vitro Techniques ; Mice ; Radioligand Assay ; Receptors, Cholinergic/*metabolism
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    Focal cortical seizures cause distant thalamic lesions (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: Topical application of convulsants to the rat sensorimotor cortex in concentrations sufficient to cause repetitive focal motor seizures resulted in acute neuropathology (dark cell neuronal degeneration and spongiform neurophil changes) involving both the cortical seizure focus and certain thalamic nuclei within seizure pathways. Changes in the cortex were localized primarily in layer IV and those in the thalamus in nuclei having reciprocal connections with the cortical focus. The spongiform neuropil changes consisted of massively dilated presynaptic axon terminals in the cortex and postsynaptic dendrites in the thalamus. The dendritic and dark cell changes resemble the excitotoxic damage caused by glutamate and aspartate. Since these putative transmitters may be released locally from recurrent collaterals and remotely from corticothalamic axons, excessive release of glutamate or aspartate may account for the changes in both sites. The abnormal axons in sensory cortex appear to be terminals of thalamocortical neurons. Swelling of these axons may be caused by excessive anti- and orthodromic firing in the course of focal motor seizures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, R C -- Olney, J W -- MH-38894/MH/NIMH NIH HHS/ -- NS-09156/NS/NINDS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123229" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Cerebral Cortex/*physiopathology/ultrastructure ; Microscopy, Electron ; Neurons/physiology/ultrastructure ; Rats ; Rats, Inbred Strains ; Seizures/*physiopathology ; Thalamus/*physiopathology
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    Phagocyte impotence caused by an invasive bacterial adenylate cyclase (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-03
    Description: For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble, heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic cells and catalyzes the unregulated formation of adenosine 3',5'-monophosphate (cyclic AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic AMP-governed processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Confer, D L -- Eaton, J W -- 5T32H- L07062/PHS HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):948-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287574" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Bordetella pertussis/*enzymology ; Cells, Cultured ; Cyclic AMP/biosynthesis ; Humans ; Macrophages/physiology ; Neutrophils/physiology ; Phagocytes/*physiology ; Rabbits ; Superoxides/metabolism ; Temperature
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    Interference with dimethylhydrazine induction of colon tumors in mice by epsilon-aminocaproic acid (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The antifibrinolytic agent epsilon-aminocaproic acid given in the drinking water to Swiss ICR/Ha mice significantly counteracted the appearance of colorectal tumors induced by 21 weekly infections of 1,2-dimethylhydrazine. The drug affected both the number and the location of the tumors and, in some animals, altogether prevented their appearance. The low concentrations of epsilon-aminocaproic acid in the plasma of four control mice given the agent labeled with carbon-14 for 3 days suggest that the effect may depend not on inhibition of plasminogen activator activity, but on interference with the binding of some substance to the strong lysine binding site of plasminogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corasanti, J G -- Hobika, G H -- Markus, G -- New York, N.Y. -- Science. 1982 May 28;216(4549):1020-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6805074" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*chemically induced ; Aminocaproates/*pharmacology ; Animals ; Colonic Neoplasms/*chemically induced ; Dimethylhydrazines/*antagonists & inhibitors ; Female ; Male ; Methylhydrazines/*antagonists & inhibitors ; Mice ; Neoplasms, Experimental/chemically induced ; Plasminogen/metabolism ; Plasminogen Activators/antagonists & inhibitors ; Plasminogen Inactivators ; Protein Binding
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    Fragment spanning the SV40 replication origin is the only DNA sequence required in cis for viral excision (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: A 311-base pair fragment containing the SV40 origin of replication was linked to the chicken thymidine kinase gene on a recombinant plasmid. This molecule was transfected into human 143 thymidine kinase-deficient (TK-) cells, and colonies positive for thymidine kinase were selected. When cell lines derived from these colonies were fused to permissive simian cells that produce SV40 T antigen, the recombinant plasmid excised itself from the human cellular genome and replicated with a high copy number per cell. These results show that this segment of the viral genome is the only sequence required in cis to mediate SV40 excision and replication upon fusion to permissive cells. In addition, we have shown that excised plasmids apparently identical to the input DNA can be efficiently rescued in Escherichia coli. SV40 excision and replication may therefore be useful for the recovery of cloned genes from eukaryotic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conrad, S E -- Liu, C P -- Botchan, M R -- CA 30490/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1223-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293055" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Chickens ; *DNA Replication ; DNA, Viral/*genetics ; Gene Expression Regulation ; Genes, Viral ; Humans ; Recombination, Genetic ; Simian virus 40/*genetics ; *Virus Replication
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    Cellular transforming genes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, G M -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):801-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Chick Embryo ; DNA/genetics ; DNA Restriction Enzymes ; DNA, Viral/genetics ; Gene Expression Regulation ; *Genes ; Genes, Viral ; Humans ; Mice ; Neoplasms/*genetics ; Oncogene Protein pp60(v-src) ; Rats ; Retroviridae/*genetics ; Transfection ; Viral Proteins/genetics
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    Anticonvulsant action of excitatory amino acid antagonists (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-21
    Description: Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D-aspartic acid. The most potent such compound, 2-amino-7-phosphonoheptanoic acid, was anticonvulsant in both test systems when given either intraperitoneally or intracerebroventricularly. Specific antagonists of excitation that is caused by amino acids provide a new class of anticonvulsant agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Croucher, M J -- Collins, J F -- Meldrum, B S -- New York, N.Y. -- Science. 1982 May 21;216(4548):899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079744" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids, Dicarboxylic/*antagonists & inhibitors ; Aminobutyrates/*pharmacology ; Animals ; *Anticonvulsants ; Disease Models, Animal ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Mice ; Mice, Inbred DBA ; Organophosphorus Compounds/*pharmacology
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    Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2'-5) oligoadenylate (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devash, Y -- Biggs, S -- Sela, I -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178155" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*pharmacology ; Animals ; Cells, Cultured ; Interferons/pharmacology ; Kinetics ; Oligonucleotides/*pharmacology ; Oligoribonucleotides/*pharmacology ; Plants, Toxic ; Tobacco/microbiology ; Tobacco Mosaic Virus/*drug effects ; Virus Replication/drug effects
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    Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: Harvey murine sarcoma virus is a retrovirus which transforms cells by means of a single virally encoded protein called p21 has. We have determined the nucleotide sequence of 1.0 kilobase in the 5' half of the viral genome which encompasses the has coding sequences and its associated regulatory signals. The nucleotide sequence has identified the amino acid sequence of two additional overlapping polypeptides which share their reading frames and the carboxyl termini with p21 but which contain additional NH2-terminal amino acids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dhar, R -- Ellis, R W -- Shih, T Y -- Oroszlan, S -- Shapiro, B -- Maizel, J -- Lowy, D -- Scolnick, E -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):934-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287572" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Transformation, Viral ; Cells, Cultured ; Defective Viruses/*genetics ; Genes, Viral ; Oncogene Protein p21(ras) ; Peptide Fragments ; Protein Biosynthesis ; Protein Conformation ; RNA, Viral/genetics ; Sarcoma Viruses, Murine/*genetics ; Viral Proteins/analysis/*genetics
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    Cannabinoids in male mice: effects on fertility and spermatogenesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalterio, S -- Badr, F -- Bartke, A -- Mayfield, D -- DA 02342/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):315-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801767" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cannabinoids/*pharmacology ; Chromosome Aberrations/*chemically induced ; Chromosome Disorders ; Follicle Stimulating Hormone/blood ; Infertility, Male/*chemically induced/genetics ; Luteinizing Hormone/blood ; Male ; Mice ; Spermatogenesis/*drug effects ; Testosterone/blood
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    Secretion of newly taken-up ascorbic acid by adrenomedullary chromaffin cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-14
    Description: Primary cultures of bovine adrenomedullary cells accumulate carbon-14-labeled ascorbic acid through a saturable and energy-dependent process. The newly taken-up ascorbate is released concomitantly with catecholamines upon stimulation of chromaffin cell secretion. The release of ascorbate is Ca2+-dependent and mediated through activation of nicotinic receptors. These results indicate that exogenous ascorbate taken up into chromaffin cells is incorporated in situ into a secretable compartment, probably the catecholamine-containing chromaffin vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniels, A J -- Dean, G -- Viveros, O H -- Diliberto, E J Jr -- New York, N.Y. -- Science. 1982 May 14;216(4547):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079733" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Medulla/*secretion ; Animals ; Ascorbic Acid/metabolism/*secretion ; Biological Transport, Active ; Calcium/physiology ; Cattle ; Cells, Cultured ; Chromaffin Granules/metabolism ; Chromaffin System/*secretion ; Nicotine/pharmacology ; Receptors, Nicotinic/physiology ; Secretory Rate/drug effects
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  • 52
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    Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dratman, M B -- Futaesaku, Y -- Crutchfield, F L -- Berman, N -- Payne, B -- Sar, M -- Stumpf, W E -- HD03110/HD/NICHD NIH HHS/ -- MH29549/MH/NIMH NIH HHS/ -- NS09914/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):309-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053582" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain/cytology/*metabolism ; Brain Mapping ; Male ; Rats ; Rats, Inbred Strains ; Triiodothyronine/*metabolism
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    "Myeloma" (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, T B -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):107.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089546" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Hybridomas ; Mice ; *Multiple Myeloma ; Plasmacytoma ; *Terminology as Topic
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  • 54
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    Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eicher, E M -- Washburn, L L -- Whitney, J B 3rd -- Morrow, K E -- AM 17947/AM/NIADDK NIH HHS/ -- GM 20919/GM/NIGMS NIH HHS/ -- RR 01183/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089579" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Crosses, Genetic ; Disorders of Sex Development/genetics ; Female ; Fertility ; Gonadal Dysgenesis/genetics ; Male ; Mice ; Mice, Inbred C57BL/genetics ; Muridae/*genetics ; Ovary/embryology ; Phenotype ; *Sex Chromosomes ; *Sex Determination Analysis ; Testis/abnormalities/embryology ; *Y Chromosome
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    Hypotensive effect of fasting: possible involvement of the sympathetic nervous system and endogenous opiates (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Fasting lowers blood pressure to a greater extent in spontaneously hypertensive rats than in normotensive rats. While fasting reduced cardiac sympathetic activity to an equivalent extent in both groups of animals, only in the hypertensive rats did fasting elicit an opiate-mediated vasodepressor response that was independent of sympathetic withdrawal. Both sympathetic nervous system suppression and endogenous opiate activation, therefore, may contribute to the hypotensive effect of fasting in the spontaneously hypertensive rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Einhorn, D -- Young, J B -- Landberg, L -- AM 20378/AM/NIADDK NIH HHS/ -- HL 24084/HL/NHLBI NIH HHS/ -- RR 76/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):727-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Pressure/drug effects ; Endorphins/*physiology ; *Fasting ; Hypertension/physiopathology ; Male ; Myocardium/metabolism ; Naltrexone/pharmacology ; Norepinephrine/metabolism ; Rats ; Rats, Inbred Strains ; Sympathetic Nervous System/*physiology
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  • 56
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    Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faustman, D -- Lacy, P -- Davie, J -- Hauptfeld, V -- AI-12734/AI/NIAID NIH HHS/ -- AM-01226/AM/NIADDK NIH HHS/ -- GM-07200/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):157-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Complement System Proteins ; Diabetes Mellitus, Experimental/immunology ; Erythrocytes/immunology ; Graft Survival ; Histocompatibility Antigens Class II/*immunology ; Immune Sera ; Immunization ; Immunosuppression ; *Islets of Langerhans Transplantation ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Transplantation, Homologous
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    Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-04
    Description: Exposure of mice to ultraviolet radiation results in the development of suppressor T lymphocytes in lymphoid organs, followed by the appearance of primary skin cancers. The presence or absence of these suppressor lymphocytes determines whether or not primary cancers will develop in the ultraviolet-irradiated skin. This demonstrates the importance of immunological regulatory pathways in carcinogenesis and provides an example of immunological surveillance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, M S -- Kripke, M L -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 4;216(4550):1133-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6210958" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Immune Tolerance ; Mice ; Neoplasms, Experimental/immunology ; Neoplasms, Radiation-Induced/*immunology ; Skin Neoplasms/etiology/*immunology ; T-Lymphocytes/*immunology ; T-Lymphocytes, Regulatory/*immunology ; Ultraviolet Rays
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    Biological diversity in metastatic neoplasms: origins and implications (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- Hart, I R -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):998-1003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112116" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/pathology ; Clone Cells ; Humans ; Immunity ; Melanoma/genetics/pathology ; Mice ; Mice, Inbred Strains ; Mutation ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology ; Phenotype ; Skin Neoplasms/genetics/pathology
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    Placental mononuclear phagocytes as a source of interleukin-1 (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Mouse and human placental tissue contains a large number of mononuclear phagocytes. These cells, isolated from placenta, were shown to produce the multifaceted immune factor interleukin-1. Activity in the supernatants of 48-hour mononuclear phagocyte cultures was associated with a 12,000- to 18,000-dalton protein, consistent with known interleukin-1 characteristics. Stimulation of phagocytosis with latex beads increased the production and release of interleukin-1 from these placental cells, which may be a useful source of this protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flynn, A -- Finke, J H -- Hilfiker, M L -- CA 24474/CA/NCI NIH HHS/ -- CA 34107/CA/NCI NIH HHS/ -- RR 00210/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6981846" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Culture Media ; Humans ; Interleukin-1/*biosynthesis ; Interleukin-2/analysis ; Mice ; Phagocytes/*immunology ; Placenta/cytology/*immunology
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    Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-05
    Description: Clinically involved psoriatic epidermis maintains its histological appearance, increased labeling index, and increased level of plasminogen activator after being grafted onto athymic nude mice. Uninvolved psoriatic epidermis develops increases in plasminogen activator activity after being grafted onto athymic nude mice; this is accompanied by an increased labeling index. Thus, psoriatic skin can develop markers of psoriasis independent of the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraki, J E -- Briggaman, R A -- Lazarus, G S -- 5 R01 AM10546/AM/NIADDK NIH HHS/ -- 5F05-TW-02774-02/TW/FIC NIH HHS/ -- R01 AM19067/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):685-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7036342" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Disease Models, Animal ; Humans ; Mice ; Mice, Nude ; Plasminogen Activators/*metabolism ; Psoriasis/enzymology/*pathology ; Skin/pathology ; Skin Transplantation
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Active genes are sensitive to deoxyribonuclease I during metaphase (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-13
    Description: The active exogenous murine leukemia virus sequences of mouse cells growing in culture are preferentially digested by deoxyribonuclease I in metaphase chromosomes. As determined by nuclear nick translation, all of the gene sequences of these cells active during interphase are in a deoxyribonuclease I-sensitive conformation during metaphase. This method of nick translation can therefore be used to label chromosomes in situ in order to visualize the active regions of the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gazit, B -- Cedar, H -- Lerer, I -- Voss, R -- GM 20483/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):648-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6283640" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromosomes, Human ; DNA/*genetics ; Deoxyribonuclease I ; Deoxyribonucleases/*pharmacology ; Endonucleases/*pharmacology ; Fibroblasts/metabolism ; Genes, Viral ; Humans ; Interphase ; Leukemia Virus, Murine/genetics ; *Metaphase ; Mice ; RNA, Viral/*genetics ; Transcription, Genetic
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    Intracellular pH of mitogen-stimulated lymphocytes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: Mitogenic stimulation of mouse lymphocytes results in two sequential intracellular alkalinizations. The first shift of intracellular pH from 7.18 to 7.35 coincides with early biochemical events following mitogenic stimulation. The second alkalinization begins 12 hours after stimulation and rises in parallel with the rate of thymidine incorporation. The results suggest that intracellular alkalinization following stimulation may play a key role in the enhancement of cellular activation and mitogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gerson, D F -- Kiefer, H -- Eufe, W -- New York, N.Y. -- Science. 1982 May 28;216(4549):1009-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281887" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/physiology ; DNA Replication ; *Hydrogen-Ion Concentration ; *Lymphocyte Activation ; Lymphocytes/drug effects/*physiology ; Mice ; Mitogens/pharmacology ; Phosphotransferases/metabolism ; Spleen ; T-Lymphocytes/physiology ; Time Factors
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    Histocompatibility and isoenzyme differences in commercially supplied "BALB/c" mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: BALB/c mice obtained commercially were found to differ significantly from the standard phenotype of BALB/c strain mice. Isoenzyme tests and H-2 haplotype analyses indicated that the majority of mice from two of the three sources tested appeared mixed, frequently heterozygous, and did not consistently express either the expected H-2 or glucose phosphate isomerase type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahan, B -- Auerbach, R -- Alter, B J -- Bach, F H -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):379-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytotoxicity Tests, Immunologic ; Female ; Flow Cytometry ; Genetic Markers ; Glucose-6-Phosphate Isomerase/genetics ; H-2 Antigens/genetics/immunology ; Inbreeding ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred BALB C/*genetics ; Phenotype
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    Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: Cultured human lymphocytes and rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoreses. In both cell types the 95,000-dalton (beta) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasuga, M -- Karlsson, F A -- Kahn, C R -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031900" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Growth Hormone/pharmacology ; Humans ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/metabolism ; Lymphocytes ; Macromolecular Substances ; Molecular Weight ; Phosphorylation ; Rats ; Receptor, Insulin/*metabolism
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    Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-05
    Description: Gene transfer and immunoselection were used in the identification of a BALB/c genomic clone containing an H-2Ld gene (clone 27.5). Transformation of thymidine kinase-negative C3H mouse L cells with the cloned 27.5 DNA together with the herpes simplex virus tk gene produced transformants expressing Ld molecules detected by radioimmune assay with monoclonal hybridoma antibodies to Ld antigens. The foreign Ld gene products expressed by cloned mouse L cell transformants were shown to be virtually indistinguishable from BALB/c spleen Ld molecules by two-dimensional electrophoretic analysis of H-2Ld immunoprecipitates. These results indicate that the genomic clone 27.5 contains a functional BALB/c H-2Ld gene and demonstrate the usefulness of this approach for identifying the gene products encoded by cloned genes which are members of a multigene family. Furthermore, the ability to place cell-surface recognition molecules on the surfaces of foreign cells provides a powerful opportunity for functional analyses of these molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodenow, R S -- McMillan, M -- Orn, A -- Nicolson, M -- Davidson, N -- Frelinger, J A -- Hood, L -- CA 22662/CA/NCI NIH HHS/ -- CA 26199/CA/NCI NIH HHS/ -- GM 06965/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Genes ; H-2 Antigens/*genetics ; Isoelectric Point ; L Cells (Cell Line) ; Mice ; Mice, Inbred BALB C/*genetics ; Transformation, Genetic
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    Chromosomal assignment of the endogenous proto-oncogene C-abl (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage. This virus is a recombinant between the parental Moloney murine leukemia virus and a cellular gene termed C-abl. By analysis of a series of mouse x Chinese hamster hybrid celllines containing various mouse chromosomes, we have mapped the C-abl gene to mouse chromosome 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goff, S P -- D'Eustachio, P -- Ruddle, F H -- Baltimore, D -- CA-14051/CA/NCI NIH HHS/ -- GM-09966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293057" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus/*genetics ; Animals ; B-Lymphocytes ; Cell Transformation, Viral ; Chromosome Mapping ; Cricetinae ; Cricetulus ; Hybrid Cells/analysis ; Leukemia Virus, Murine/*genetics ; Mice ; *Oncogenes
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    Myocardial injury: quantitation by cell sorting initiated with antimyosin fluorescent spheres (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Spheres coated with antibodies specific for myosin were used to detect myocardial cell membrane disruption by scanning electron microscopy. Injury in a population of cultured myocytes as then followed and measured by fluorescence-activated cell sorting. This approach provides a unique method for quantitating the evolution of myocardial injury and potentially for assessing the efficacy of interventions aimed at myocardial protection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khaw, B A -- Scott, J -- Fallon, J T -- Cahill, S L -- Haber, E -- Homcy, C -- HL-17665/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1050-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7051286" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/ultrastructure ; Cell Separation ; Coronary Disease/pathology ; Culture Media ; Flow Cytometry ; Fluorescent Antibody Technique ; Glucose/pharmacology ; Mice ; Microscopy, Electron, Scanning ; Myocardium/*pathology ; Myosins/*analysis/immunology
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    Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-17
    Description: The biosynthesis of melanin is initiated by the catalytic oxidation of tyrosine to dopa by tyrosinase in a reaction that requires dopa as a cofactor. Tyrosine then catalyzes the dehydrogenation of dopa to dopaquinone. The subsequent reactions can proceed spontaneously in vitro. Tyrosinase, purified from murine melanomas and the skins of brown mice, has now been shown to catalyze a third reaction in mammalian melanogenesis, namely the conversion of 5,6-dihydroxyindile to melanochrome. This reaction requires dopa as a cofactor and is inhibited by tyrosine. Conversely, 5,6-dihydroxyindole inhibits the oxidation of tyrosine to dopa, so that the relative concentrations of tyrosine and 5,6-dihydroxyindole within the mammalian pigment cell are capable of regulating melanogenesis in a previously unrecognized fashion. Tyrosinase has the unusual property of catalyzing three distinct reactions within a single biochemical pathway: the hydroxylation of a monophenol, the dehydrogenation of a catechol, and the dehydrogenation of a dihydroxyindole. The first and third of these reactions require dopa as a cofactor; in the second reaction, dopa is a substrate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korner, A -- Pawelek, J -- DA-01147/DA/NIDA NIH HHS/ -- DA-05186/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1163-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810464" target="_blank"〉PubMed〈/a〉
    Keywords: Catechol Oxidase/*metabolism ; Cells, Cultured ; Dihydroxyphenylalanine/metabolism ; Indoles/metabolism ; Kinetics ; Melanins/*biosynthesis ; Melanoma/enzymology ; Monophenol Monooxygenase/*metabolism ; Neoplasms, Experimental/enzymology ; Substrate Specificity ; Tyrosine/metabolism
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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    NIH 3T3 cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Littlefield, J W -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; *Cell Line ; Mice ; Mice, Inbred BALB C ; National Institutes of Health (U.S.) ; United States
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    Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-19
    Description: Specific receptors for gonadotropin-releasing hormone (GnRH) in cultured rat pituitary cells were increased by subnanomolar concentrations of GnRH agonists and decreased by high concentrations of these peptides. The antagonist [D-Phe2, Pro3, D-Phe6]GnRH did not alter GnRH binding capacity and blocked the increase in sites induced by GnRH. These findings provide direct evidence for the homologous regulation of GnRH receptors by physiological concentrations of the hypothalamic peptide, an action that could mediate the cyclical and postcastration increases in GnRH receptors and responsiveness of the pituitary gonadotrophs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loumaye, E -- Catt, K J -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):983-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6296998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Feedback ; Female ; Gonadotropin-Releasing Hormone/analogs & derivatives/metabolism/pharmacology ; Pituitary Gland/secretion ; Pituitary Hormone-Releasing Hormones/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/*pharmacology ; Receptors, LHRH
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    Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-02
    Description: The ornithine decarboxylase inhibitor DL-alpha-difluoromethyl ornithine inhibited a proliferation-associated increase in ornithine decarboxylase activity in cultured human promyelocytic leukemia cells, resulting in a marked suppression of cell proliferation and subsequent cell loss. It also inhibited increases in ornithine decarboxylase activity associated with the phorbol ester-induced conversion of promyelocytic HL-60 cells to monocyte-like cells and the retinoic acid-induced conversion to granulocyte-like cells. However, the inhibition of ornithine decarboxylase activity did not prevent cellular differentiation. These results suggest that polyamine biosynthesis has a specific role in cell proliferation rather than in inducing differentiation that is not accompanied by proliferation. The data also demonstrate that cessation of proliferation in HL-60 cells is not necessarily associated with differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luk, G D -- Civin, C I -- Weissman, R M -- Baylin, S B -- AM-27447/AM/NIADDK NIH HHS/ -- CA-18404/CA/NCI NIH HHS/ -- HL-19157/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 2;216(4541):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6950518" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxy-Lyases/*physiology ; Cell Adhesion ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Female ; Granulocytes/pathology ; Humans ; Leukemia, Myeloid, Acute/*enzymology/pathology ; Macrophages/pathology ; Ornithine Decarboxylase/*physiology ; Polyamines/biosynthesis ; Tetradecanoylphorbol Acetate/pharmacology ; Tretinoin/pharmacology
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    Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-06
    Description: The ability of tumor cells to metastasize may be related to their ability to promote aggregation of host platelets. The use of inhibitors of cysteine proteinases resulted in parallel inhibition of B16 amelanotic melanoma-induced platelet aggregation and of a cathepsin B activity. The antimetastatic agent prostacyclin inhibited platelet aggregation induced by the tumor cells and by papain, a cathepsin B-mimicking agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honn, K V -- Cavanaugh, P -- Evens, C -- Taylor, J D -- Sloane, B F -- CA29405/CA/NCI NIH HHS/ -- CA29997/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):540-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046053" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cathepsin B ; Cathepsins/*metabolism ; Cells, Cultured ; Cysteine Endopeptidases ; Endopeptidases/*metabolism ; Epoprostenol/*pharmacology ; Humans ; Melanoma/metabolism ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental/metabolism ; Papain/pharmacology ; Platelet Aggregation/*drug effects ; Prostaglandins/*pharmacology ; Protease Inhibitors/pharmacology
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    The case of the misplaced gene (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):983-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/genetics ; Humans ; Mice ; Neoplasms/*genetics ; *Oncogenes ; Translocation, Genetic
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    Ti plasmids as gene carriers (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079762" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; *Plant Tumors ; Plants/*genetics ; *Plasmids ; Rhizobium/genetics
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    Cloning the genes of the MHC (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071587" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular/*methods ; Genes ; Humans ; *Major Histocompatibility Complex ; Mice
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    A new treatment for burn victims (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):522.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089578" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Bandages ; *Biological Dressings ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Epidermis/cytology ; Humans ; Surgical Flaps ; Wound Healing
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    DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: A 3.4-kilobase DNA fragment containing the gene coding for the E alpha chain of an Ia (I region-associated) antigen from the BALB/c mouse has been sequenced. It contains at least three exons, which correlate with the major structural domains of the E alpha chain-the two external domains alpha 1 and alpha 2, and the transmembrane-cytoplasmic domain. The coding sequence of the mouse E alpha gene shows striking homology to its counterpart at the DNA and protein levels. The translated alpha 2 exon demonstrates significant similarity to beta 2-microglobulin, to immunoglobulin constant region domains, and to certain domains of transplantation antigens. These observations and those of others suggest that the Ia antigen, transplantation antigen, and immunoglobulin gene families share a common ancestor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNicholas, J -- Steinmetz, M -- Hunkapiller, T -- Jones, P -- Hood, L -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1229-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6815800" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Genes ; *Genes, MHC Class II ; Macromolecular Substances ; Mice ; Mice, Inbred BALB C/*genetics ; beta 2-Microglobulin/genetics
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    Cysteamine: a potent and specific depletor of pituitary prolactin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millard, W J -- Sagar, S M -- Landis, D M -- Martin, J B -- AM 26252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):452-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Cysteamine/*pharmacology ; Domperidone/pharmacology ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Pituitary Gland, Anterior/*metabolism ; Prolactin/analysis/*metabolism/secretion ; Rats ; Receptors, Dopamine/physiology ; Spiperone/pharmacology
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    Neonatal treatment with antiserum to prolactin lowers blood pressure in rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Prolactin administration reportedly increases blood pressure in rats and rabbits. To study the effects of prolactin deficiency on blood pressure, rats were given saline, normal rabbit serum, or rabbit antiserum to rat prolactin on postnatal days 2 to 5. Both males and females given antiserum had significantly lower blood pressure at 14 weeks than rats given saline or normal rabbit serum. Blood pressure differences between females given antiserum and females given saline disappeared during and following pregnancy. The antiserum also lowered the concentration of prolactin in plasma 49 percent in males and decreased the prolactin response to ether stress in both sexes. These results suggest that endogenous prolactin is involved in blood pressure regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, D E -- Buckman, M T -- Peake, G T -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):162-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Blood Pressure ; Female ; Immune Sera/pharmacology ; Male ; Pregnancy ; Pregnancy, Animal ; Prolactin/blood/immunology/*physiology ; Rabbits ; Rats ; Rats, Inbred Strains ; Sex Characteristics ; Sodium Chloride/pharmacology
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  • 82
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    Opioid-like analgesia in defeated mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-19
    Description: Mice exposed to repeated attacks by other mice showed decreased nociception in response to radiant heat focused on their tails. This form of analgesia was blocked by centrally acting opiate antagonists and was not observed in morphine-tolerant mice; furthermore, mice repeatedly subjected to defeat. Mice of the CXBK strain, which respond weakly to morphine, displayed only moderate analgesia following defeat. These findings suggest that endogenous opioid-mediated analgesic mechanisms are readily activated by situations involving biologically significant forms of stress, such as defeat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- Thompson, M L -- Shuster, L -- AA-05122/AA/NIAAA NIH HHS/ -- DA-02632/DA/NIDA NIH HHS/ -- DA-05054/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1520-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199758" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/physiology ; Animals ; Behavior, Animal/physiology ; Endorphins/*physiology ; Humans ; Mice ; Pain/*physiopathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-05
    Description: The sequence of a gene, denoted 27.5, encoding a transplantation antigen for the BALB/c mouse has been determined. Gene transfer studies and comparison of the translated sequence with the partial amino acid sequence of the Ld transplantation antigen establish that gene 27.5 encodes an Ld polypeptide. A comparison of the gene 27.5 sequence with several complementary DNA sequences suggests that the BALB/c mouse may contain a number of closely related L-like genes. Gene 27.5 has eight exons that correlate with the structural domains of the transplantation antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, K W -- Sher, B T -- Sun, Y H -- Eakle, K A -- Hood, L -- 1 T32 GM07616/GM/NIGMS NIH HHS/ -- GM 06965/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):679-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058332" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular/methods ; Genes ; H-2 Antigens/*genetics ; *Major Histocompatibility Complex ; Mice ; Mice, Inbred BALB C/*genetics ; Plasmids ; Repetitive Sequences, Nucleic Acid
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  • 84
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    Liposomes as gene carriers: efficient transformation of mouse L cells by thymidine kinase gene (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: Stable transformation of mouse L cells deficient in thymidine kinase was achieved by liposome-mediated transfer of a recombinant plasmid carrying the thymidine kinase gene. Ten percent of the recipient cells expressed thymidine kinase activity. The transformed phenotype (for example, 200 out of 10(6) cells) was stable under selective and nonselective conditions. The liposome technique is compared with other methods currently used for gene transfer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaefer-Ridder, M -- Wang, Y -- Hofschneider, P H -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053567" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol ; *DNA, Recombinant ; L Cells (Cell Line) ; Liposomes ; Mice ; Phosphatidylserines ; Thymidine Kinase/*genetics ; Transformation, Genetic
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  • 85
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    Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B L -- Lam, L F -- AG-02114/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071590" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Calcium/*metabolism ; *Cell Survival ; Cells, Cultured ; Child ; Cystic Fibrosis/*metabolism/pathology ; Female ; Fibroblasts ; Humans ; Infant ; Male
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  • 86
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    Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-30
    Description: Mice immunized with insulin developed antibodies to both insulin and the insulin receptor. The antibodies to insulin receptor displaced labeled insulin from insulin receptors and mimicked the actions of insulin in stimulating the oxidation of glucose and its incorporation into lipids, and in inhibiting lipolysis. The antibodies to insulin receptor could be blocked by or bound to the antibodies to insulin, and therefore were identified as anti-idiotypes. Thus, immunization against a hormone may activate spontaneously an idiotype-anti-idiotype network resulting in antibodies to the hormone receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shechter, Y -- Maron, R -- Elias, D -- Cohen, I R -- AM 26766/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):542-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7041258" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Autoantibodies/*immunology ; Immunoglobulin Idiotypes/*immunology ; Insulin/*immunology ; Mice ; Receptor, Insulin/*immunology/physiology
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  • 87
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    Virus-induced alterations in homeostasis: alteration in differentiated functions of infected cells in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The noncytopathic lymphocytic choriomeningitis virus displays a tropism for the anterior lobe of the murine pituitary gland. Virus replicates in cells that make growth hormone. This results in a diminished synthesis of growth hormone with a concomitant clinical picture of retarded growth and hypoglycemia. However, there is no morphologic evidence of either cell necrosis or inflammation in the anterior lobe of the pituitary. Hence, during infection in vivo, a noncytopathic virus may turn off the "differentiation" or "luxury" function of a cell while not killing that cell (loss of vital function). This is turn can disrupt homeostasis and cause disease. This model illustrates a novel way whereby viruses may cause disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oldstone, M B -- Sinha, Y N -- Blount, P -- Tishon, A -- Rodriguez, M -- von Wedel, R -- Lampert, P W -- AI-09484/AI/NIAID NIH HHS/ -- CA-33448/CA/NCI NIH HHS/ -- NS-12428/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1125-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146898" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Growth ; Growth Hormone/*biosynthesis ; *Homeostasis ; Lymphocytic Choriomeningitis/*physiopathology ; Lymphocytic choriomeningitis virus/immunology/*physiology ; Mice ; Pituitary Gland, Anterior/microbiology
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  • 88
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    Gut reactions of radioactive nitrite after intratracheal administration in mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: Intratracheal administration to mice of radioactive nitrite labeled with nitrogen-13 (13NO2-) (half-life, 9.96 minutes) in dosages that do not cause pharmacological perturbation reveals that oxidative and reductive reactions occur in different organs. Oxidation of 13NO2- to radioactive nitrate (13NO3-) predominates in the blood and liver. Reduction of 13NO2- occurs in those mice that harbor intestinal microflora; this reduction does not occur in germ-free mice. The intestinal reduction products include ammonium, glutamate, glutamine, and urea. With a detection limit of about 0.01 percent of the instilled nitrogen-13, no labeled nitrosamines were detected within 30 minutes. Reduced nitrogen-13 is transported out of the intensive into the circulatory system and appears in the urine along with 13NO3-. The biological half-period for 13NO2- destruction is about 7 minutes, and both oxidation and reduction products are formed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thayer, J R -- Chasko, J H -- Swartz, L A -- Parks, N J -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211766" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Half-Life ; Intestines/*metabolism/microbiology ; Intubation, Intratracheal ; Mice ; Mice, Inbred BALB C ; Nitrites/administration & dosage/*metabolism ; Nitrogen Radioisotopes ; Oxidation-Reduction ; Specific Pathogen-Free Organisms ; Tissue Distribution
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  • 89
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    Nerve growth factor attenuates neurotoxic effects of taxol on spinal cord-ganglion explants from fetal mice (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: Most neurons in organotypic cultures of dorsal root ganglia from 13-day-old fetal mice require high concentrations of nerve growth factor for survival during the first week after explanation. These nerve growth factor-enhanced sensory neurons mature and innervate the dorsal regions of attached spinal cord tissue even after the removal of exogenous growth factor after 4 days. In cultures exposed for 4 days to nerve growth factor and taxol (a plant alkaloid that promotes the assembly of microtubules) and returned to medium without growth factor, greater than 95 percent of the ganglionic neurons degenerated and the spinal cord tissues were reduced almost to monolayers. In contrast, when the recovery medium was supplemented with nerve growth factor, the ganglionic neurons and dorsal (but not ventral) cord tissue survived remarkably well. Dorsal cord neurons do not normally require an input from dorsal root ganglia for long-term maintenance in vitro, but during and after taxol exposure they become dependent for survival and recovery on the presence of neurite projections from nerve growth-factor-enhanced dorsal root ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peterson, E R -- Crain, S M -- NS-14990/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):377-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124041" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaloids/*pharmacology ; Animals ; Culture Media ; Female ; Fetus ; Ganglia, Spinal/drug effects ; Mice ; Nerve Growth Factors/*pharmacology/physiology ; Neurons, Afferent/drug effects ; Neurons, Efferent/drug effects ; Organ Culture Techniques ; Paclitaxel ; Spinal Cord/drug effects
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  • 90
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    Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Administration of synthetic ovine corticotropin-releasing factor led to rapid, parallel increases in adrenocorticotropin and alpha-melanocyte-stimulating hormone concentrations in rat plasma. Prior treatment with dexamethasone almost completely blocked the adrenocorticotropin response but not the increase in melanocyte-stimulating hormone. These data demonstrate that corticotropin-releasing factor is a potent stimulator not only of adrenocorticotropin secretion from the corticotrophs of the anterior pituitary gland but also of peptide secretion from the intermediate lobe. Such data suggest that melanocyte-stimulating hormone and beta-endorphin play a role in the physiological response to stress.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Proulx-Ferland, L -- Labrie, F -- Dumont, D -- Cote, J -- Coy, D H -- Sveiraf, J -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):62-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6283632" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/blood ; Animals ; Castration ; Corticotropin-Releasing Hormone/*pharmacology ; Dexamethasone/pharmacology ; Female ; Melanocyte-Stimulating Hormones/blood/*secretion ; Pituitary Gland/drug effects/*secretion ; Pituitary Gland, Anterior/secretion ; Rats ; Rats, Inbred Strains
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  • 91
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    The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: A pituitary glycopeptide whose amino acid sequence was previously identified has now been recognized as the final portion of the precursor to arginine vasopressin and its associated neurophysin. Immunocytochemical techniques with antiserums against this 39 amino acid peptide and vasopressin were used to study their distribution in the rat central nervous system. The peptide is located in vasopressin-synthesizing cells in the neurosecretory magnocellular nuclei. Positively stained fibers project from the magnocellular nuclei through the median eminence to the posterior pituitary. Studies of the homozygous Brattleboro rat, which is known to be deficient in the production of vasopressin and its related neurophysin, also show the absence of immunoreactivity to this peptide. These immunocytochemical data strongly indicate that the peptide is synthesized with vasopressin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, S J -- Seidah, N G -- Chretien, M -- DA00154/DA/NIDA NIH HHS/ -- DA02265/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):853-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6125034" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Arginine Vasopressin/*metabolism ; Brain/*metabolism ; Dynorphins ; Endorphins/metabolism ; Hypothalamus/metabolism ; Male ; Neurophysins/*metabolism ; Peptide Fragments ; Pituitary Gland, Posterior/metabolism ; Protein Precursors/analysis/*metabolism ; Rats ; Rats, Inbred Strains
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  • 92
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    Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-12
    Description: Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without malnutrition." The mice on the restricted diet averaged 10 to 20 percent increases in mean and maximum survival times compared to the control mice. Spontaneous lymphoma was inhibited by the food restriction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weindruch, R -- Walford, R L -- AG-00424/AG/NIA NIH HHS/ -- CA-26164/CA/NCI NIH HHS/ -- CA-9030/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1415-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063854" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; *Aging ; Animals ; Body Weight ; *Diet ; Energy Intake ; Lymphoma/*epidemiology ; Mice
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  • 93
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    Monoclonal anitbodies in the lymphatics: toward the diagnosis and therapy of tumor metastases (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Monoclonal antibodies subcutaneously injected into mice track to regional lymph nodes and specifically label target cells there. The lymphatic route of administration can be expected to provide much higher sensitivity, higher target-to-background ratio, faster localization, and lower toxicity than the intravenous route when the aim is to diagnose or treat tumor metastases or lymphoma in the lymph nodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, J N -- Parker, R J -- Keenan, A M -- Dower, S K -- Morse, H C 3rd -- Sieber, S M -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1334-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Monoclonal/administration & dosage ; Injections, Subcutaneous ; Lymph Nodes/*cytology ; Major Histocompatibility Complex ; Methods ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/*diagnosis
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  • 94
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    Lesion-induced sprouting in the rat dentate gyrus is inhibited by repeated ethanol administration (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-11-19
    Description: The effect of ethanol on hippocampal axonal sprouting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcholinesterase staining in the outer molecular layer and a concomitant increase in the width of the pale-staining commissural-associational zone of the dentate gyrus. Other rats were given ethanol (11.3 +/- 0.45 grams per kilogram) for 2 weeks before and 9 days after receiving the lesion. Ethanol abolished the expansion of the commissural-associated zone. The effect of ethanol on sprouting axons suggests that it may inhibit recovery of function after brain injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, J R -- Lind, M D -- Demuth, R M -- Parker, E S -- Alkana, R L -- Cassell, M -- Black, A C Jr -- AA-03884/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):809-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/drug effects/*physiology ; Ethanol/*pharmacology ; Female ; Hippocampus/drug effects/*physiology ; Male ; Rats ; Rats, Inbred Strains
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  • 95
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    Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23) (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whang-Peng, J -- Kao-Shan, C S -- Lee, E C -- Bunn, P A -- Carney, D N -- Gazdar, A F -- Minna, J D -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):181-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274023" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma, Small Cell/*genetics ; Cells, Cultured ; *Chromosome Deletion ; Chromosomes, Human, 1-3 ; Humans ; Karyotyping ; Lung Neoplasms/*genetics
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  • 96
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    High efficiency latency and activation of herpes simplex virus in human cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-17
    Description: Herpes simplex virus (HSV) exists in humans in a latent form that can be activated. To characterize the molecular basis of the cell-virus interactions and to analyze the state of the latent HSV genome, an in vitro model system was established. In this system a large fraction of the latently infected cells contain an HSV genome that can be activated. Cell survival was reduced minimally after repression of high multiplicity HSV type 1 (HSV-1) infection of human fibroblast cells with (E)-5-(2-bromovinyl)-2'-deoxyuridine in combination with human leukocyte interferon (IFN-alpha). A minimum of 1 to 3 percent of the surviving cells contained an HSV genome that could be activated either by human cytomegalovirus superinfection or reduction in incubation temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wigdahl, B L -- Scheck, A C -- De Clercq, E -- Rapp, F -- CA 09124/CA/NCI NIH HHS/ -- CA 18450/CA/NCI NIH HHS/ -- CA 27503/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1145-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6180477" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/analogs & derivatives/therapeutic use ; Cells, Cultured ; Cytarabine/pharmacology ; Herpes Simplex/*physiopathology/therapy ; Humans ; Interferons/therapeutic use ; Simplexvirus/*physiology ; Virus Activation ; *Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 97
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    Morphologic effect of dimethyl sulfoxide on the blood-brain barrier (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Dimethyl sulfoxide (DMSO) opens the blood-brain barrier of mice to the enzymatic tracer horseradish peroxidase. A single injection of horseradish peroxidase in 10 to 15 percent DMSO into the tail vein along with 10 to 15 percent DMSO delivered intraperitoneally allowed horseradish peroxidase to fill the extracellular clefts throughout the brain within 2 hours. In the absence of DMSO, peroxidase failed to enter brain parenchyma except through the circumventricular organs. Opening of the blood-brain barrier by DMSO is reversible. Dimethyl sulfoxide stimulated the pinocytosis of horseradish peroxidase by the cerebral endothelium; the peroxidase was then directed to lysosomal dense bodies for degradation. Vesicular transport of horseradish peroxidase from the luminal to the abluminal wall of the endothelial cell was not observed. Dimethyl sulfoxide did not alter the morphology of endothelial cells or brain parenchyma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broadwell, R D -- Salcman, M -- Kaplan, R S -- NS18030-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):164-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier/*drug effects ; Brain Chemistry ; Dimethyl Sulfoxide/administration & dosage/*pharmacology ; Endothelium/drug effects ; Extracellular Space/analysis ; Female ; Horseradish Peroxidase/analysis/metabolism ; Injections, Intraperitoneal ; Injections, Intravenous ; Mice ; Pinocytosis/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: When injected continuously into the lateral ventricles of the rat, somatostatin increased the frequency of the migrating myoelectric complexes of the small intestine in a dose-related manner. A significant increase was obtained at a dose as low as 0.066 picomole per minute. In contrast, cholecystokinin octapeptide decreased the frequency of the migrating myoelectric complex of the small intestine or disrupted this pattern when injected into the lateral ventricle at rates of 0.073 to 0.23 picomole per minute. These findings support the hypothesis that somatostatin and cholecystokinin octapeptide act on central nervous system structures that are involved in the control of intestinal motility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bueno, L -- Ferre, J P -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124037" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholecystokinin/administration & dosage/analogs & derivatives/*pharmacology ; Dose-Response Relationship, Drug ; *Gastrointestinal Motility ; Injections, Intraventricular ; Male ; Rats ; Rats, Inbred Strains ; Somatostatin/administration & dosage/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Plasmodium falciparum gametocytes from culture in vitro develop to sporozoites that are infectious to primates (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Gametocytes of two strains of the human malaria parasite Plasmodium falciparum have been produced in high density by means of a continuous-flow cultivation system. The gametocytes of these two strains infected a mean of 36 percent and 71 percent, respectively, of Anopheles freeborni mosquitoes that fed on a suspension of red blood cells containing the culture gametocytes. Sporozoites harvested from the infected mosquito salivary glands were infective to the chimpanzee (Pan troglodytes) and the owl monkey (Aotus trivirgatus).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, C C -- Collins, W E -- Nguyen-Dinh, P -- Barber, A -- Broderson, J R -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1048-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7051285" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/parasitology ; Aotus trivirgatus/parasitology ; Blood/parasitology ; Cells, Cultured ; Culture Media ; Humans ; Pan troglodytes/parasitology ; Plasmodium falciparum/*growth & development ; Salivary Glands/parasitology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Nerve fiber growth on defined hydrogel substrates (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-21
    Description: Cultured neurons become attached to hydrogel substrates prepared from 2-hydroxyethylmethacrylate but grow few nerve fibers unless fibronectin, collagen, or nerve growth factor is incorporated into the hydrogel. Antibodies to fibronectin inhibit nerve fiber growth on hydrogels containing fibronectin, which suggests that growing neurons interact directly with proteins trapped in the hydrogel. The adhesive requirements for attachment of neurons appear distinct and possibly less specific than those for fiber growth. Defined hydrogel substrates offer a controlled method for analyzing complex substrates that support nerve fiber growth and neuronal differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carbonetto, S T -- Gruver, M M -- Turner, D C -- 2S07RR0540220/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 May 21;216(4548):897-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Differentiation ; Cells, Cultured ; Chick Embryo ; Collagen/pharmacology ; Culture Media ; Fibronectins/pharmacology ; Nerve Growth Factors/pharmacology ; Neurons/*cytology ; *Polyhydroxyethyl Methacrylate ; *Polymethacrylic Acids
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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