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  • 1
    Publication Date: 2012-08-21
    Description: Environmental Science & Technology DOI: 10.1021/es301107c
    Print ISSN: 0013-936X
    Electronic ISSN: 1520-5851
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
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  • 2
    Publication Date: 2014-09-10
    Description: Precise spatiotemporal control of mRNA translation machinery is essential to the development of highly complex systems like the neocortex. However, spatiotemporal regulation of translation machinery in the developing neocortex remains poorly understood. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2013-10-26
    Description: alpha-Synuclein (alpha-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson's disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerative disease. Using unbiased phenotypic screens as an alternative to target-based approaches, we discovered an N-aryl benzimidazole (NAB) that strongly and selectively protected diverse cell types from alpha-syn toxicity. Three chemical genetic screens in wild-type yeast cells established that NAB promoted endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. These same steps were perturbed by alpha-syn itself. Thus, NAB identifies a druggable node in the biology of alpha-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993916/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993916/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tardiff, Daniel F -- Jui, Nathan T -- Khurana, Vikram -- Tambe, Mitali A -- Thompson, Michelle L -- Chung, Chee Yeun -- Kamadurai, Hari B -- Kim, Hyoung Tae -- Lancaster, Alex K -- Caldwell, Kim A -- Caldwell, Guy A -- Rochet, Jean-Christophe -- Buchwald, Stephen L -- Lindquist, Susan -- 5R01GM069530/GM/NIGMS NIH HHS/ -- F32GM099817/GM/NIGMS NIH HHS/ -- F32NS061419/NS/NINDS NIH HHS/ -- GM58160/GM/NIGMS NIH HHS/ -- K01 AG038546/AG/NIA NIH HHS/ -- R01 GM058160/GM/NIGMS NIH HHS/ -- R15 NS075684/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research (WIBR), Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24158909" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzimidazoles/chemistry/*pharmacology ; Caenorhabditis elegans ; Cells, Cultured ; *Cytoprotection ; Drug Evaluation, Preclinical ; Endosomal Sorting Complexes Required for Transport/*genetics ; Gene Regulatory Networks/*drug effects ; Neurodegenerative Diseases/*metabolism ; Neurons/*drug effects/metabolism ; Neuroprotective Agents/*pharmacology ; Parkinson Disease/metabolism ; Rats ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae Proteins/*genetics ; Small Molecule Libraries/chemistry/pharmacology ; Ubiquitin-Protein Ligase Complexes/*genetics ; Ubiquitin-Protein Ligases/*genetics ; alpha-Synuclein/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-03-19
    Description: Mice exposed to repeated attacks by other mice showed decreased nociception in response to radiant heat focused on their tails. This form of analgesia was blocked by centrally acting opiate antagonists and was not observed in morphine-tolerant mice; furthermore, mice repeatedly subjected to defeat. Mice of the CXBK strain, which respond weakly to morphine, displayed only moderate analgesia following defeat. These findings suggest that endogenous opioid-mediated analgesic mechanisms are readily activated by situations involving biologically significant forms of stress, such as defeat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- Thompson, M L -- Shuster, L -- AA-05122/AA/NIAAA NIH HHS/ -- DA-02632/DA/NIDA NIH HHS/ -- DA-05054/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1520-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199758" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/physiology ; Animals ; Behavior, Animal/physiology ; Endorphins/*physiology ; Humans ; Mice ; Pain/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1942-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of atmospheric chemistry 4 (1986), S. 125-155 
    ISSN: 1573-0662
    Keywords: Carbon dioxide ; interannual variations ; Southern Oscillation ; El Nino
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract A method is described for the analysis of the interannual variability of background atmospheric carbon dioxide concentration. The analysis is carried out on the data from 6 observatories for which records of 〉8 years were available. A global-scale interannual variation of CO2 concentration in the troposphere with a characteristic time-scale of 2–3 years has been confirmed throughout the period of the records. These variations are estimated to be associated with carbon cycle imbalances of 2–3 Gt or annual net exchanges between the atmosphere and another carbon reservoir(s) at a rate of about 1.2 Gt of carbon per year. Lag correlations and amplitude comparisons between the records suggests a low latitude southern hemisphere origin to this phenomenon. The interannual variations of CO2 increase are found to be correlated with those observed in data for Pacific sea surface temperatures and Pacific witd stress, the Southern Oscillation Index and the Quasi-Biennial Oscillation. However multiple regression studies found that once the Southern Oscillation index is used as an explanatory variable for CO2 variations, the inclusion of additional geophysical variables does not give any significant improvement in the regression.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-9680
    Keywords: filter strip ; NPS pollution ; constructed wetland ; soil bioengineering ; best management practice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A multi-species riparian buffer strip (MSRBS) system was designed and placed along a Central Iowa stream in 1990. Bear Creek, is typical of many streams in Central Iowa where the primary land use along the stream's length is row crop (corn and soybeans) production agriculture or intensive riparian zone grazing. The Bear Creek watershed is long (∼ 35 km), narrow (3–6 km), and drains 7,661 ha of farmland. The MSRBS system is a 20 m wide filter strip consisting of four or five rows of fast-growing trees planted closest to the stream, then two shrub rows, and finally a 7 m wide strip of switchgrass established next to the agricultural fields. The 1.0 km long system, is located on an operational farm and is laid out in a split block design on both sides of Bear Creek. An integral part of this system is a streambank stabilization soil bioengineering component and a constructed wetland to intercept NPS pollutants in field drainage tile water flow. It is hypothesized that this system will function effectively as a nutrient, pesticide, and sediment sink for NPS pollutants coming from the upslope agricultural fields. Prior to establishment of the MSRBS system, the riparian zone along Bear Creek was grazed and row cropped to the stream edge. Since 1990 there has been dramatic alteration in the appearance and functioning of this riparian zone. After four growing seasons, the fast-growing tree species (cottonwood, silver maple, willow, and green ash) range in height from 2.4 m to over 5.5 m. Mean (four-year) biomass production of silver maple was 8.4 dry Mg ha−1, more than twice to seven times the yield from other silver maple research plots in Central Iowa. The shrub species, selected because of desired wildlife benefits, have done well in terms of survival and growth with ninebark, Nannyberry viburnum and Nanking cherry doing the best. The switchgrass grass has developed into a dense stand that effectively stops concentrated flow from the agriculture fields and allows for infiltration rates well above the field rate. Early root biomass data indicate significantly more roots below the MSRBS than agricultural fields. This suggests better soil stabilization, absorption of infiltrated water, and soil-root-microbe-NPS pollutant interaction characteristics within the MSRBS system than the cropped fields. Nitrate-nitrogen concentrations in the MSRBS never exceed 2 mg l−1 whereas the levels in the adjacent agricultural fields exceed 12 mg l−1. The water quality data collected suggest that the MSRBS is effective in reducing NPS pollutants in the vadose and saturated zone below the system. The soil bioengineering revetments have stabilized the streambank and minimized bank collapse. Initial results (from 4 months of operation) from the constructed wetland (built in summer 1994) indicate nitrate-nitrogen concentrations of the tile inflow water 〉15 mg l−1 whereas, the outflow water had a nitrate-nitrogen concentration of 〈3 mg l−1. Over time this wetland should become more effective in removing excess nitrogen moving with the tile flow from the agricultural fields because of the accumulation of organic matter from the cattails. Overall the MSRBS system seems to be functioning as expected. This MSRBS system offers farmers a way to intercept eroding soil, trap and transform NPS pollution, stabilize streambanks, provide wildlife habitat, produce biomass for on-farm use, produce high-quality hardwood in the future, and enhance the aesthetics of the agroecosystem. As a streamside best management practice (BMP), the MSRBS system complements upland BMPs and provides many valuable private and public market and non-market benefits.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 1994-11-01
    Print ISSN: 0047-2425
    Electronic ISSN: 1537-2537
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley
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  • 9
    Publication Date: 2015-01-22
    Description: New sea surface salinity (SSS) observations derived from satellite remote sensing platforms provide a comprehensive view of salt exchanges across boundary currents such as the Gulf Stream. The high resolution (45km spatial resolution and three-day repeat subcycle) of the Soil Moisture and Ocean Salinity (SMOS) observations allows detection (and tracking) of meander and ring structures of the Gulf Stream from SSS maps. These structures are however not resolved by the relatively lower resolution (100km and seven-day repeat subcycle) of Aquarius observations. A recently developed fusion technique, based on singularity analysis technique, is applied in this study to reconstruct these mesoscale (from 100km and 3 days) features in Aquarius-derived products. New quarter-degree SSS maps are obtained by fusing Aquarius data with three different geophysical templates: sea surface height (SSH) from AVISO, SSS from SMOS, and sea surface temperature (SST) from AVHRR. The proposed method exploits the theoretical correspondence among the singularity exponents of different maps of ocean-surface remotely sensed scalar fields. The analysis results over the year 2012 show that merging Aquarius with SSH data provides a series of negative salinity anomalies that better collocate with the position of the cyclonic eddies identified from sea level anomaly maps. This result is consistent with the hypothesis that this SLA derived cyclonic eddies in this area are indeed CCRs shed off the GS. This article is protected by copyright. All rights reserved.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
    Publication Date: 2013-10-08
    Description: We present 109–115 GHz (3 mm) wide-field spectral line observations of 12 CO, 13 CO and C 18 O J  = 1–0 molecular emission and 5.5 and 8.8 GHz (6 and 3 cm) radio continuum emission towards the high-mass star-forming complex known as G305. The morphology of G305 is dominated by a large evacuated cavity at the centre of the complex driven by clusters of O stars surrounded by molecular gas. Our goals are to determine the physical properties of the molecular environment and reveal the relationship between the molecular and ionized gas and star formation in G305. This is in an effort to characterize the star-forming environment and constrain the star formation history in an attempt to evaluate the impact of high-mass stars on the evolution of the G305 complex. Analysis of CO emission in G305 reveals 156 molecular clumps with the following physical characteristics; excitation temperatures ranging from 7 to 25 K, optical depths of 0.2–0.9, H 2 column densities of 0.1–4.0 10 22 cm –2 , clump masses ranging from 10 2 to 10 4 M and a total molecular mass of 〉3.5 10 5 M . The 5.5 and 8.8 GHz radio continuum emission reveals an extended low surface brightness ionized environment within which we identify 15 large-scale features with a further eight smaller sources projected within these features. By comparing to mid-infrared emission and archival data, we identify nine H ii regions, seven compact H ii regions, one UC H ii region and four extended regions. The total integrated flux of the radio continuum emission at 5.5 GHz is ~180 Jy corresponding to a Lyman continuum output of 2.4 10 50  photons s –1 . We compare the ionized and molecular environment with optically identified high-mass stars and ongoing star formation, identified from the literature. Analysis of this data set reveals a star formation rate of 0.008–0.016 M yr –1 and efficiency of 7–12 per cent, allows us to probe the star formation history of the region and discuss the impact of high-mass stars on the evolution of G305.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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