Publication Date:
1984-07-20
Description:
The structure of rat preproatrial natriuretic factor ( preproANF ) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, C E -- Duby, A D -- Choi, E -- Graham, R M -- Haber, E -- Homcy, C -- Smith, J A -- Seidman, J G -- HL-070208/HL/NHLBI NIH HHS/ -- HL-19259/HL/NHLBI NIH HHS/ -- NS-19583/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):324-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6234658" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Atrial Natriuretic Factor
;
Base Sequence
;
*Cloning, Molecular
;
DNA/*genetics
;
Muscle Proteins/*genetics
;
*Natriuresis
;
Nucleic Acid Hybridization
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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