The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone

Science. 1984 Jul 20;225(4659):324-6. doi: 10.1126/science.6234658.

Abstract

The structure of rat preproatrial natriuretic factor ( preproANF ) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Atrial Natriuretic Factor
  • Base Sequence
  • Cloning, Molecular*
  • DNA / genetics*
  • Muscle Proteins / genetics*
  • Natriuresis*
  • Nucleic Acid Hybridization
  • Rats

Substances

  • Muscle Proteins
  • Atrial Natriuretic Factor
  • DNA

Associated data

  • GENBANK/K02062
  • GENBANK/K02063