Publication Date:
1982-05-14
Description:
Primary cultures of bovine adrenomedullary cells accumulate carbon-14-labeled ascorbic acid through a saturable and energy-dependent process. The newly taken-up ascorbate is released concomitantly with catecholamines upon stimulation of chromaffin cell secretion. The release of ascorbate is Ca2+-dependent and mediated through activation of nicotinic receptors. These results indicate that exogenous ascorbate taken up into chromaffin cells is incorporated in situ into a secretable compartment, probably the catecholamine-containing chromaffin vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniels, A J -- Dean, G -- Viveros, O H -- Diliberto, E J Jr -- New York, N.Y. -- Science. 1982 May 14;216(4547):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079733" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Medulla/*secretion
;
Animals
;
Ascorbic Acid/metabolism/*secretion
;
Biological Transport, Active
;
Calcium/physiology
;
Cattle
;
Cells, Cultured
;
Chromaffin Granules/metabolism
;
Chromaffin System/*secretion
;
Nicotine/pharmacology
;
Receptors, Nicotinic/physiology
;
Secretory Rate/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
