Publication Date:
1982-08-06
Description:
The ability of tumor cells to metastasize may be related to their ability to promote aggregation of host platelets. The use of inhibitors of cysteine proteinases resulted in parallel inhibition of B16 amelanotic melanoma-induced platelet aggregation and of a cathepsin B activity. The antimetastatic agent prostacyclin inhibited platelet aggregation induced by the tumor cells and by papain, a cathepsin B-mimicking agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honn, K V -- Cavanaugh, P -- Evens, C -- Taylor, J D -- Sloane, B F -- CA29405/CA/NCI NIH HHS/ -- CA29997/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):540-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046053" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cathepsin B
;
Cathepsins/*metabolism
;
Cells, Cultured
;
Cysteine Endopeptidases
;
Endopeptidases/*metabolism
;
Epoprostenol/*pharmacology
;
Humans
;
Melanoma/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Neoplasms, Experimental/metabolism
;
Papain/pharmacology
;
Platelet Aggregation/*drug effects
;
Prostaglandins/*pharmacology
;
Protease Inhibitors/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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