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  • Female  (231)
  • Mice  (112)
  • Dose-Response Relationship, Drug  (59)
  • American Association for the Advancement of Science (AAAS)  (360)
  • 1975-1979  (360)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (360)
  • Springer  (12)
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Year
  • 1
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    Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for alpha-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, M A -- Yen, R C -- Itkin, P -- Goss, S J -- Seegmiller, J E -- Bakay, B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1016-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218284" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Female ; Genetic Linkage ; Humans ; Hybrid Cells ; Hypoxanthine Phosphoribosyltransferase/genetics ; Phosphotransferases/*genetics ; Ribose-Phosphate Pyrophosphokinase/*genetics ; *Sex Chromosomes ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, B -- Levine, G -- Hakala, T R -- Solter, D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):844-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Neoplasm ; Clone Cells/immunology ; Mice ; Neoplasms, Experimental/diagnosis/immunology ; Radionuclide Imaging/*methods ; Teratoma/*diagnosis/immunology
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  • 3
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    Opioid peptides modulate luteinizing hormone secretion during sexual maturation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blank, M S -- Panerai, A E -- Friesen, H G -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endorphins/antagonists & inhibitors/*physiology ; Estradiol/pharmacology ; Female ; Luteinizing Hormone/blood/*secretion ; Male ; Naloxone/antagonists & inhibitors/pharmacology ; Rats ; Secretory Rate/drug effects ; Sexual Maturation/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Obesity genes: beneficial effects in heterozygous mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, either ob/+ or db/+, survived a prolonged fast significantly longer than normal homozygotes (+/+); this suggests that the heterozygotes exhibited increased metabolic efficiency, a feature normally associated with both homozygous mutants. The existence of this thriftiness trait, if manifested by heterozygous carriers in wild populations, would lend credence to the thrifty gene concept of diabetes. Beneficial effects of normally deleterious genes may have played a role in the development of diabetes-susceptible human populations, as well as having provided the survival advantage that has allowed both the development and successful establishment of species in desert and other less affluent regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coleman, D L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):663-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760211" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation ; Diabetes Mellitus, Experimental/*genetics/metabolism ; Fasting ; Glucose/metabolism ; Heterozygote ; Insulin/blood ; Mice ; Mice, Obese/*genetics
    Print ISSN: 0036-8075
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  • 5
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    Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture. Methotrexate dose-related increases occur in the concentrations of intracellular 5-fluorouracil ribonucleotides and 5-fluoro-2'-deoxyuridylate and in the incorporation of 5-fluorouracil into RNA. These increases are correlated with increased concentrations of intracellular phosphoribosylpyrophosphate. It is proposed that the enhanced formation of ribonucleotides of 5-fluorouracil and the subsequent incorporation of these compounds into RNA in methotrexate-treated cells may account for synergism between these agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cadman, E -- Heimer, R -- Davis, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Drug Administration Schedule ; Drug Synergism ; Fluorouracil/metabolism/*pharmacology ; Leukemia L1210 ; Methotrexate/*pharmacology ; Mice ; Phosphoribosyl Pyrophosphate/metabolism ; RNA, Neoplasm/metabolism ; Ribonucleotides/metabolism ; Thymidylate Synthase/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Ingested mineral fibers: elimination in human urine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
    Print ISSN: 0036-8075
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  • 7
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    Preferential transmission of the Z deficient allele of alpha 1-antitrypsin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapuis-Cellier, C -- Arnaud, P -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313077" target="_blank"〉PubMed〈/a〉
    Keywords: *Alleles ; Child ; Female ; Heterozygote Detection ; Humans ; Male ; *Polymorphism, Genetic ; Sex Factors ; alpha 1-Antitrypsin/genetics ; *alpha 1-Antitrypsin Deficiency
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  • 8
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    Seaweed dermatitis: structure of lyngbyatoxin A (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: A highly inflammatory and vesicatory substance, lyngbyatoxin A, has been isolated from the lipid extract of a Hawaiian shallow-water variety of Lyngbya majuscula Gomont; its gross structure was determined from chemical and spectral data. Lyngbyatoxin A is closely related to teleocidin B, a poisonous substance associated with several strains of Streptomyces.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardellina, J H 2nd -- Marner, F J -- Moore, R E -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107586" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaloids/*toxicity ; Animals ; *Cyanobacteria ; Dermatitis, Contact/*etiology ; *Dermotoxins ; Indoles/toxicity ; *Marine Toxins ; Mice
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  • 9
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    Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gundersen, R W -- Barrett, J N -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/growth & development/*physiology ; Cells, Cultured ; *Chemotaxis/drug effects ; Chick Embryo ; Dose-Response Relationship, Drug ; Ganglia, Spinal/physiology ; Nerve Growth Factors/*pharmacology
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  • 10
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    Cerebral specialization, writing posture, and motor control of writing in left-handers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: It has been suggested that the inverted hand position of left-handers during writing indicates the left hemisphere of their brain is linguistically specialized and that the writing of these left-handers may be controlled via ipsilateral pathways. Electroencephalograph alpha asymmetry measures at central and parietal leads, as well as dichotic tests, differentiated right-handers from left-handers, but not inverters from noninverters. Electroencephalograph differences between hand posture groups did appear, but only at occipital leads during reading and writing tasks. Regardless of hand posture or speech lateralization, the right central region of the brain is significantly involved in the control of left-handed writing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herron, J -- Galin, D -- Johnstone, J -- Ornstein, R E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1285-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472745" target="_blank"〉PubMed〈/a〉
    Keywords: Auditory Perception/physiology ; Brain/*physiology ; Cognition/physiology ; Female ; *Functional Laterality ; Humans ; Male ; Movement ; *Posture ; Speech/physiology ; Visual Perception/physiology ; *Writing
    Print ISSN: 0036-8075
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  • 11
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    Chromosome 13 long arm interstitial deletion may result from maternal inverted insertion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoegerman, S F -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1035-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472726" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Aberrations/*genetics ; Chromosome Deletion ; Chromosome Disorders ; Chromosome Inversion ; *Chromosomes, Human, 13-15 ; Female ; Humans
    Print ISSN: 0036-8075
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  • 12
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    Vomeronasal and olfactory system modulation of maternal behavior in the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: The onset of maternal responsiveness by virgin female rats to foster pups was observed after (i) complete vomeronasal nerve cuts, (ii) partial olfactory bulb cuts, or (iii) the combined procedures. Although both vomeronasal nerve cuts and olfactory bulb cuts resulted in a more rapid onset of maternal care, relative to control animals with sham operations, animals sustaining the loss of both sources of olfactory input exhibited the shortest response latency. These findings are discussed in terms of the probable distinct functions of the two olfactory systems in the control of maternal behavior in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleming, A -- Vaccarino, F -- Tambosso, L -- Chee, P -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):372-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760196" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Animals ; Central Nervous System/*physiology ; Female ; *Maternal Behavior ; Olfactory Bulb/physiology ; Olfactory Pathways/*physiology ; Rats ; Smell/*physiology
    Print ISSN: 0036-8075
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  • 13
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    Difference between postpartum and nutritional amenorrhea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- McArthur, J W -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419411" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology/physiopathology ; Body Weight ; Female ; Humans ; Lactation ; Nutrition Disorders/complications ; Pregnancy ; Time Factors
    Print ISSN: 0036-8075
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  • 14
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    Cytidylate cyclase: possible artifacts in the methodology (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaion, R M -- Krishna, G -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):672-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytosine Nucleotides ; Liver/*enzymology ; Lyases/*metabolism ; Mice
    Print ISSN: 0036-8075
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  • 15
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    Development of the capacity for tactile information transfer between hemispheres in normal children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The hypothesis of less direct interaction between hemispheres in young children was supported by a behavioral test. Fabric samples were compared with either the same hand (same hemisphere) or with opposite hands (between hemispheres). Crossed errors were a significantly larger proportion of total errors in 3-year-olds than in 5-year-olds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galin, D -- Johnstone, J -- Nakell, L -- Herron, J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451542" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*growth & development/physiology ; Child, Preschool ; Female ; *Functional Laterality ; Humans ; Touch/*physiology
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  • 16
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    Electroencephalogram correlates of higher cortical functions (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: By means of two-stage, nonlinear multivariate pattern recognition, electroencephalograms (EEG's) were analyzed during performance of verbal and spatial tasks. Complex scalp distributions of theta-, beta-, and, to a lesser extent, alpha-band spectral intensities discriminated between the two members of a pair of tasks, such as writing sentences and Koh's block design. Small EEG asymmetries were probably attributable to limb movements and other uncontrolled noncognitive aspects of tasks. Significant EEG differences beteeen cognitive tasks were eliminated when controls for inter-task differences in efferent activity, stimulus characteristics, and performance-related factors were introduced. Each controlled task was associated with an approximately 10 percent reduction, as compared with visual fixation, in the magnitude of alpha- and beta-band spectral intensity. This effect occurred bilaterally and was approximately the same over occipital, parietal, and central regions, with some minor difference over the frontal region in the beta band. With these controls, no evidence for lateralization of different cognitive functions was found in the EEG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Zeitlin, G M -- Doyle, J C -- Yingling, C D -- Schaffer, R E -- Callaway, E -- Yeager, C L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):665-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760212" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cerebral Cortex/*physiology ; Cognition/*physiology ; *Electroencephalography ; Female ; *Functional Laterality ; Humans ; Male ; Memory/physiology ; Movement ; Pattern Recognition, Visual/physiology
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  • 17
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
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  • 18
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    Vitamin D deficiency and reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Female weanling rats from a colony maintained on a diet low in vitamin D were raised on a diet that was deficient in vitamin D but was otherwise adequate. Vitamin D deficiency was confirmed in the rats by hypocalcemia and the absence of vitamin D metabolites in blood. These females gave birth to litters that were slightly smaller than control litters from females maintained on a vitamin D-containing diet. The pups from the vitamin D-deficient mothers appeared normal throughout lactation, and at weaning had normal concentrations of calcium and phosphate in the plasma. These results indicate that vitamin D and its metabolites are not necessary for reproduction and fetal development in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halloran, B P -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):73-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling/blood ; Body Weight ; Bone Development ; Calcium/blood ; Female ; Hydroxycholecalciferols/blood ; Phosphates/blood ; Rats ; *Reproduction ; Vitamin D Deficiency/blood/*physiopathology
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  • 19
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    Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Papillary fibroblasts, when compared to reticular fibroblasts from the same skin specimen, exhibit greater proliferative capacities in vitro. These results demonstrate a difference in function between morphologically similar cells obtained from the same tissue. Such findings represent an important consideration in the study of cell aging in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Grove, G -- New York, N.Y. -- Science. 1979 May 4;204(4392):526-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Female ; Fibroblasts/cytology ; Humans ; Male ; Skin/*cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
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  • 21
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    Smallpox death in Britain challenges presumption of laboratory safety (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkes, N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):855-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419409" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Great Britain ; Humans ; Jurisprudence ; Laboratories/*standards ; Peer Review ; Safety ; Smallpox/*etiology ; World Health Organization
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  • 22
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    Cancer and environment: Higginson speaks out (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higginson, J -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1363-4, 1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472753" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; *Carcinogens ; Diet ; *Environment ; Female ; Humans ; Life Style ; Male ; Neoplasms/*etiology ; Stress, Psychological/complications
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  • 23
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    Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: 17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochberg, R B -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1138-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*analogs & derivatives/analysis/metabolism ; Female ; Iodine Radioisotopes ; Radioimmunoassay/methods ; Rats ; Receptors, Estrogen/*metabolism ; Uterus/metabolism
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  • 24
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    Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Rossier, J -- Bloom, F E -- Guillemin, R -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83674" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*physiology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid/immunology ; Enkephalins/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Radioimmunoassay
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  • 25
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    Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: The genetic linkage of the endogenous C3H/HeJ C-type ecotropic virus to phosphoglucomutase-1 (0.28, recombinant fraction) on chromosome 5 was established by means of serological assays of backcrossed mice. With a combination of serological techniques and DNA-DNA hybridization the BALB/c endogenous ecotropic virus was shown to be either closely linked or allelic with the C3H/HeJ locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ihle, J N -- Joseph, D R -- Domotor, J J Jr -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219476" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Genes ; *Genes, Viral ; Genetic Linkage ; Leukemia Virus, Murine/genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Mice, Inbred C3H/*microbiology ; Mice, Inbred Strains/genetics ; Phenotype ; Phosphoglucomutase/*genetics ; Retroviridae/*genetics
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  • 26
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    Mammary cancer: selective action of the estrogen receptor complex (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ip, M -- Milholland, R J -- Rosen, F -- Kim, U -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Cytosol/metabolism ; Estradiol/metabolism/pharmacology ; Female ; Male ; Mammary Neoplasms, Experimental/*metabolism ; Rats ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/biosynthesis/drug effects/*metabolism
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  • 27
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    DNA polymerase with characteristics of reverse transcriptase purified from human milk (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: A DNA polymerase purified from a particulate fraction of human milk has biochemical and biophysical properties similar to those of viral reverse transcriptases. This enzyme is immunologically distinct from cellular DNA polymerases obtained from a variety of human sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kantor, J A -- Lee, Y H -- Chirikjian, J G -- Feller, W F -- New York, N.Y. -- Science. 1979 May 4;204(4392):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86209" target="_blank"〉PubMed〈/a〉
    Keywords: DNA-Directed DNA Polymerase/immunology/*metabolism ; Female ; Humans ; Milk, Human/*enzymology ; Molecular Weight ; RNA-Directed DNA Polymerase/immunology/*metabolism ; Retroviridae/enzymology ; Substrate Specificity ; Templates, Genetic
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  • 28
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
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  • 29
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    3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
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  • 30
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
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  • 31
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    Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luzzatto, L -- Usanga, E A -- Bienzle, U -- Esan, G F -- Fusuan, F A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1418-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472761" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Genetic Linkage ; Glucosephosphate Dehydrogenase/blood/genetics ; *Hematopoiesis ; Heterozygote ; Humans ; Leukocytes/enzymology ; *Mosaicism ; *Sex Chromosomes ; *X Chromosome
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  • 32
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    Treatment reduces deaths from hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1386-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505012" target="_blank"〉PubMed〈/a〉
    Keywords: Antihypertensive Agents/therapeutic use ; Blood Pressure ; Diet, Sodium-Restricted ; Female ; Humans ; Hypertension/complications/*drug therapy/physiopathology ; Male ; Myocardial Infarction/etiology/prevention & control
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  • 33
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    Sex hormones and brain development (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112680" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocortical Hyperfunction/physiopathology ; Animals ; Behavior/*physiology ; Behavior, Animal/physiology ; Brain/*growth & development ; Female ; Gonadal Steroid Hormones/*physiology ; Haplorhini ; Humans ; Male ; Preoptic Area/growth & development ; Rats ; Receptors, Estrogen/metabolism ; Sex Differentiation ; Testosterone/metabolism
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  • 34
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    Scientists attack report that obstetrical medications endanger children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87012" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/*adverse effects ; Child ; Child Development/*drug effects ; Child, Preschool ; Delivery, Obstetric/methods ; Developmental Disabilities/chemically induced ; Female ; Humans ; Infant ; Infant, Newborn ; Labor, Obstetric ; Methods ; Pregnancy
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  • 35
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
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  • 36
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    Moment of inertia: psychophysical study of an overlooked sensation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The distribution of mass in an object held in the hand, as described by its moment of inertia, is a fundamental and potent but largely unrecognized contributor to the object's "feel." A limited set of experiments has produced Weber fractions for human differential sensitivity to this property in the approximate range of 1/5 to 1/3, which is about ten times the Weber fraction reported for lifted weights.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kreifeldt, J G -- Chuang, M C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):588-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493965" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysical Phenomena ; *Biophysics ; Female ; Humans ; Male ; Weight Perception/*physiology
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    Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALB/c mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C A -- Rowe, W P -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes, Viral ; Genetic Linkage ; Hybrid Cells/microbiology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Phosphoglucomutase/metabolism ; Virus Replication
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    The annual Pap smear: an idea whose time has gone? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
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  • 39
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    The HDL: the good cholestrol carriers? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223241" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Cholesterol/*blood/metabolism ; Diet ; Female ; Humans ; Lipoproteins, HDL/*blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Risk ; Running ; Sex Factors ; Tissue Distribution
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  • 40
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    Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
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  • 41
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    Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers. These abnormalities probably result from the ability of Clomid to cause long-term estrogenic stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormack, S -- Clark, J H -- New York, N.Y. -- Science. 1979 May 11;204(4393):629-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432668" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Clomiphene/*toxicity ; Fallopian Tubes/pathology ; Female ; Metaplasia ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Uterine Diseases/chemically induced/pathology ; Vaginal Diseases/chemically induced
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  • 42
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    Angiogenesis in the mouse cornea (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-28
    Description: We have developed a method that permits analysis of neovascular responses in the mouse cornea. Using this method we have demonstrated that both allogeneic lymphocytes and a variety of tumors can induce angiogenesis, but that only the latter appear capable of eliciting secondary capillary sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muthukkaruppan, V -- Auerbach, R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/*blood supply ; In Vitro Techniques ; Mice ; Mice, Inbred Strains ; Microcirculation ; Neoplasms, Experimental/*blood supply
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  • 43
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    Drug safety: phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):144, 146, 148.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451584" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; Liver Neoplasms/*chemically induced ; Mice ; Neoplasms, Experimental/chemically induced ; Phenacetin/*adverse effects/standards ; Rats
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  • 44
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    Octopamine receptors, adenosine 3',5'-monophosphate, and neural control of firefly flashing (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern. The relative potency of octopamine and various other amines in stimulating this enzyme, and effects of antagonists in blocking octopamine activation, correlate well with the known effects of these agents in affecting light production. In addition to suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing, identification of this potent enzyme should facilitate the characterization of phenylethylamine receptors in excitable tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):65-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214856" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Beetles/*physiology ; Catecholamines/pharmacology ; Cyclic AMP/*biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Kinetics ; Octopamine/*pharmacology ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Neurotransmitter/*drug effects ; Structure-Activity Relationship
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    Insulin receptor binding in obesity: a reassessment (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo--as it does in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Misbin, R I -- O'Leary, J P -- Pulkkinen, A -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1003-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472718" target="_blank"〉PubMed〈/a〉
    Keywords: Dietary Carbohydrates/metabolism ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Male ; Monocytes/metabolism ; Obesity/*metabolism ; Physical Exertion ; Receptor, Insulin/*metabolism
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  • 46
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    Nitrite promotes lymphoma incidence in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-08
    Description: Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newberne, P M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Lymphocytes/drug effects ; Lymphoma/*chemically induced ; Neoplasms, Experimental/chemically induced ; *Nitrites/pharmacology ; Rats
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  • 47
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    Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Mice with the mutant gene tottering (tg, chromosome 8, autosomal recessive) show, in adolescence, abnormal bursts of bilaterally synchronous spike waves as revealed in electrocorticograms recorded over long periods. The spike waves are accompanied by behavioral "absence" attacks and intermittent focal motor seizures showing somatotopic progression. Cerebral metabolic activity during seizures was assayed by autoradiography of brain sections from mice injected intravenously with 14C-labeled 2-deoxyglucose. Metabolic activity was increased bilaterally in selected brainstem structures. Spontaneous electrocorticographic and clinical seizures of this general pattern were recognized hitherto only in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noebels, J L -- Sidman, R L -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1334-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572084" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior/*physiology ; Brain/growth & development/physiopathology ; Electrocardiography ; Epilepsy/*genetics/physiopathology ; Humans ; Mice ; Mice, Neurologic Mutants/genetics/*physiology ; Neural Pathways/physiopathology ; Seizures/physiopathology ; Stereotyped Behavior/*physiology
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    Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: The restriction enzymes Hpa II and Msp I both recognize the sequence 5'-CCGG (C, cytosine; G, guanine). However, Hpa II cuts mouse liver DNA to fragments four times larger than does Msp I. The size of DNA cut by Msp I is close to that predicted from base composition and nearest neighbor analysis. The most probable explanation of these results is that in mouse the site 5'-CCGG is highly methylated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, J -- Roberts-Ems, J -- Riggs, A D -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1019-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424726" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/*metabolism ; DNA (Cytosine-5-)-Methyltransferase/metabolism ; DNA Restriction Enzymes/metabolism ; Liver/metabolism ; Methylation ; Mice ; Molecular Weight ; Substrate Specificity
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    Drug discrimination training with progressively lowered doses (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-17
    Description: Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Overton, D A -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):720-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlordiazepoxide/pharmacology ; Cyclazocine/pharmacology ; Discrimination Learning/*physiology ; Dose-Response Relationship, Drug ; Fentanyl/pharmacology ; *Pharmacology ; Phenobarbital/pharmacology ; Rats ; Scopolamine Hydrobromide/pharmacology
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    NCI bioassays yield a trail of blunders (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1287-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay/methods ; *Carcinogens ; Legislation as Topic ; Mice ; *National Institutes of Health (U.S.) ; Research Design/standards ; Research Support as Topic ; United States
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    Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, J W -- Parker, J B -- Haussler, M R -- Boass, A -- Toverud, S V -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451573" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/blood ; Dihydroxycholecalciferols/*blood ; Female ; Hydroxycholecalciferols/*blood ; *Lactation ; Parathyroid Glands/physiology ; Parathyroid Hormone/physiology ; Phosphorus/blood ; Pregnancy ; *Pregnancy, Animal ; Rats
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    Microwave radiation and chlordiazepoxide: synergistic effects on fixed-interval behavior (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-30
    Description: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
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    Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-20
    Description: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweeny, G D -- Jones, K G -- Cole, F M -- Basford, D -- Krestynski, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):332-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dioxins/*toxicity ; Enzyme Induction ; Iron/*deficiency ; Liver/pathology ; Mice ; Microsomes, Liver/enzymology ; Mixed Function Oxygenases/metabolism ; Porphyrias/*chemically induced ; Tetrachlorodibenzodioxin/*toxicity ; Uroporphyrinogen Decarboxylase/metabolism
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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    Nickel carbonyl: prenatal exposure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
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    Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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    Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yotti, L P -- Chang, C C -- Trosko, J E -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication/*drug effects ; Cell Membrane/drug effects ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Resistance ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/pharmacology ; Thioguanine/pharmacology
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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    Phase advance of the circadian sleep-wake cycle as an antidepressant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehr, T A -- Wirz-Justice, A -- Goodwin, F K -- Duncan, W -- Gillin, J C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):710-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227056" target="_blank"〉PubMed〈/a〉
    Keywords: Bipolar Disorder/*physiopathology/therapy ; Body Temperature Regulation ; *Circadian Rhythm ; Female ; Humans ; Middle Aged ; Motor Activity/physiology ; Sleep, REM/*physiology
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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    Role of nuclear size in cell growth initiation (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-22
    Description: Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yen, A -- Pardee, A B -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Division ; Cell Nucleus/physiology/*ultrastructure ; Cells, Cultured/*physiology/ultrastructure ; Clone Cells/ultrastructure ; DNA/biosynthesis ; Mice
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    Surgeon general seeks physicians' help in DES alert (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Jan 12;203(4376):159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758685" target="_blank"〉PubMed〈/a〉
    Keywords: Diethylstilbestrol/*adverse effects ; Drug Information Services ; Female ; Government Agencies ; Humans ; Mesonephroma/*chemically induced ; United States ; Vaginal Neoplasms/*chemically induced
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    Sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alving, C R -- Schneider, I -- Swartz, G M Jr -- Steck, E A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ceramides/therapeutic use ; Erythrocytes/parasitology ; Glycolipids/*therapeutic use ; Liposomes/therapeutic use ; Liver/parasitology ; Malaria/parasitology/*therapy ; Mice ; Plasmodium berghei ; Structure-Activity Relationship
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    Chemical carcinogens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 16;203(4381):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens/administration & dosage ; Dose-Response Relationship, Drug ; Mice ; Mutagens ; Neoplasms, Experimental/chemically induced ; Rats ; Vinyl Chloride/*toxicity ; Vinyl Compounds/*toxicity
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    Effects of anesthesia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 23;203(4382):705.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419403" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Drug-Induced ; Abortion, Spontaneous/*chemically induced ; Anesthetics/*adverse effects ; Female ; Humans ; Male ; Pregnancy
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    Delayed neurotoxicity of phenylphosphonothioate esters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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    Canine Babesia new to North America (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-29
    Description: A domestic dog residing in New England suffered a fatal febrile illness caused by a Babesia infection. The morphology of these intraerythrocytic protozoa and the range of hosts that could be infected experimentally suggested that the parasite was B. gibsoni. Although this tick-bourne disease is enzootic in wild and domestic Canidae in Africa and Asia, it appears to be new to the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J F -- Magnarelli, L A -- Donner, C S -- Spielman, A -- Piesman, J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropod Vectors ; Babesia/classification/cytology ; Babesiosis/epidemiology/*parasitology/transmission ; Cricetinae ; Dog Diseases/*parasitology ; Dogs ; Erythrocytes/parasitology ; Mice ; United States
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    Yearly report on carcinogens could be a potent weapon in the war on cancer (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):525-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760203" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Dose-Response Relationship, Drug ; Government Agencies ; Humans ; Legislation, Drug ; Neoplasms/*prevention & control ; United States
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    Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-20
    Description: Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caruso, T P -- Takemori, A E -- Larson, D L -- Portoghese, P S -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86208" target="_blank"〉PubMed〈/a〉
    Keywords: *Alkylating Agents ; Animals ; Chlorambucil/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Guinea Pigs ; Hydromorphone/*analogs & derivatives ; In Vitro Techniques ; Morphine/pharmacology ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives/pharmacology ; Nitrogen Mustard Compounds/*pharmacology ; Norepinephrine/pharmacology ; Oxymorphone/*analogs & derivatives/pharmacology ; Phenoxybenzamine/pharmacology ; Receptors, Opioid/*drug effects
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    Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casper, R F -- Yen, S S -- Wilkes, M M -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462193" target="_blank"〉PubMed〈/a〉
    Keywords: *Climacteric ; Dopamine/blood ; Epinephrine/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood/*secretion ; Middle Aged ; Norepinephrine/blood ; Prolactin/blood
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    Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-02
    Description: The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H W -- Israel, M A -- Garon, C F -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):887-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217088" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Coliphages/*genetics ; DNA Restriction Enzymes/metabolism ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; Polyomavirus/*genetics ; Risk ; Tumor Virus Infections/*genetics ; Virus Replication
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    Prolonged inhibition of neurons by neuroendocrine cells in Aplysia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: In the abdominal ganglion of Aplysia, a burst of action potentials in peptide-secreting neuroendocrine cells, the bag cells, produces slow inhibition of two identified bursting pacemaker neurons. The inhibition is due to slow hyperpolarizing potential that reduces bursting pacemaker activity for 3 hours or more. The slow inhibitory potential results from a large and prolonged increase in membrane conductance to potassium ions as well as a slower ionic process that is relatively independent of membrane conductance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, P -- Mayeri, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):417-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35827" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Aplysia/*physiology ; Electric Conductivity ; Electric Stimulation ; Female ; Ganglia/physiology ; *Neural Inhibition ; Neurosecretory Systems/*physiology ; Neurotransmitter Agents/physiology ; Oviposition ; Peptides/physiology
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  • 73
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    2-Deoxy-D-glucose maps movement-specific nervous activity in the second visual ganglion of Drosophila (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Adult Drosophila were fed with tritium labeled deoxyglucose prior to a 5-hour period of visual stimulation. A flickering disk of light and a moving grating were presented to the left and right eyes, respectively. Autoradiography revealed enhanced labeling solely in that part of the second optic ganglion (medulla) whose visual field was stimulated by movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchner, E -- Buchner, S -- Hengstenberg, R -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):687-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Drosophila melanogaster/anatomy & histology/*physiology ; Female ; Ganglia/metabolism ; Motion Perception/*physiology ; Neurons/*metabolism ; Visual Pathways/metabolism ; Visual Perception/physiology
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  • 74
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    Chlorpromazine and its metabolites alter polymerization and gelation of actin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elias, E -- Boyer, J L -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574316" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Chlorpromazine/*analogs & derivatives/*pharmacology ; Cytoskeleton/drug effects ; Dose-Response Relationship, Drug ; Gels ; Protein Binding/drug effects ; Rabbits ; Viscosity
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  • 75
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    Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, T K -- Lester, G E -- Lorenc, R S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dihydroxycholecalciferols/biosynthesis ; Female ; Fetal Blood/metabolism ; Hydroxycholecalciferols/*metabolism ; Hydroxylation ; Kidney/embryology/metabolism ; *Nephrectomy ; Placenta/metabolism ; Pregnancy ; *Pregnancy, Animal
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  • 76
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    Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: Toxaphene, the most widely used chlorinated insecticide, is mutagenic in the Salmonella test without requiring liver homogenate for activity. This insecticide is a complex mixture (more than 177 polychloroterpenes) with carcinogenic activity in rodents. Some but not all of the mutagenic components are easily separated from the insecticidal ingredients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hooper, N K -- Ames, B N -- Saleh, M A -- Casida, J E -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):591-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377495" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Drug ; Insecticides/*pharmacology ; *Mutagens ; Mutation ; Salmonella typhimurium/drug effects ; Toxaphene/*pharmacology
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  • 77
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
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  • 78
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    [Interpreting "imitative" responses in early infancy] (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobson, S W -- Kagan, J -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451595" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/*physiology ; Female ; Humans ; *Infant ; *Infant, Newborn ; Male ; Movement ; Tongue/physiology
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  • 79
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    Calcitonin: inhibitory effect on eating in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
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  • 80
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    Pseudohermaphroditism in Ilyanassa obsoleta (Mollusca: Neogastropoda) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Field studies, a rearing and maintenance program, and a transfer experiment have shown that anomalous male traits found in some female Ilyanassa obsoleta are an expression of environmentally controlled psuedohermaphroditism. The particular pattern of pseudohermaphroditism discovered in this species has not been reported previously from any other group, but may be characteristic of the Neogastropoda.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenner, M G -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/pathology/*physiopathology ; Female ; Male ; Sex Differentiation ; Snails/growth & development/*physiology
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  • 81
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    Genetic resistance to aflatoxin in Japanese quail (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Progress was rapid in attempts to develop lines of quail resistant to acute aflatoxicosis induced by oral dosing with aflatoxin. After five generations of selection, 8- and 11-fold differences were present in mortality between two selected lines and their respective control lines. These quail lines should be of value in investigating the physiological basis of resistance to aflatoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marks, H L -- Wyatt, R D -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515737" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxins/*pharmacology ; Animals ; Coturnix/*genetics ; *Drug Resistance ; Female ; Genes ; Male ; Quail/*genetics ; Selection, Genetic
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  • 82
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    Dysmenorrhea: basic research leads to a rational therapy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):175-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109921" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclooxygenase Inhibitors ; Dysmenorrhea/drug therapy/*physiopathology ; Female ; Humans ; Progesterone/physiology ; Prostaglandins/*physiology ; Uterine Contraction
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  • 83
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    Albumin-deficient rat mutant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagase, S -- Shimamune, K -- Shumiya, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/*blood ; Chromosome Disorders ; Crosses, Genetic ; Female ; Immunoelectrophoresis ; Male ; Mutation ; Rats/*genetics ; Serum Albumin/*deficiency ; Serum Globulins/analysis
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  • 84
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    Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
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  • 85
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    Phenacetin studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
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  • 86
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    Calmodulin activation of adenylate cyclase in pancreatic islets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
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  • 87
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    Semliki forest virus: cause of a fatal case of human encephalitis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: A fatal case of human encephalitis has been observed for which our results indicate that Semliki Forest virus (SFV) was the etiologic agent. This is surprising in view of the fact that this virus, which has been widely studied, was believed to be one of the arboviruses nonpathogenic for man. Described are the clinical course, the virological examinations performed, and the histopathological findings in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willems, W R -- Kaluza, G -- Boschek, C B -- Bauer, H -- Hager, H -- Schutz, H J -- Feistner, H -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1127-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424742" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antigens, Viral/analysis ; Arbovirus Infections/*etiology ; Encephalitis/*etiology/microbiology/pathology ; Female ; Humans ; Laboratory Infection/*etiology/microbiology ; *Semliki forest virus/immunology
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  • 88
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    The hyperactive child syndrome (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-28
    Description: The behavioral characteristics of the hyperactive child are described at different stages of development. Recent and sometimes controversial research findings are discussed with respect to prevalence, etiology, treatment, and outcome. It is concluded that this syndrome can best be understood in terms of interactions between social, psychological, and biological variables.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- Hechtman, L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1348-54.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472752" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Attention Deficit Disorder with Hyperactivity/etiology ; Child ; Child Behavior Disorders/diagnosis/*etiology/therapy ; Child, Preschool ; Environment ; Female ; Humans ; Infant ; Male ; Methylphenidate/therapeutic use ; Sex Ratio ; Syndrome ; Terminology as Topic
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  • 89
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    Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Horseradish peroxidase (HRP) in the presence of specific immunoglobulin G antibody to HRP is selectively absorbed from the gut lumen and transferred by intestinal epithelial cells to the lamina propria in newborn rats. The HRP is not transferred in detectable amounts in the absence of the antibody. Transport of maternally derived antigen via antigen-antibody complexes may have important influences on the developing immune system in young mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamson, D R -- Powers, A -- Rodewald, R -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):567-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; *Antigen-Antibody Complex ; *Antigens ; Biological Transport, Active ; Female ; Horseradish Peroxidase/immunology ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; *Intestinal Absorption ; Jejunum/*immunology/metabolism ; Male ; Rats
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  • 90
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Fetal research ethics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brackbill, Y -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504983" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; Disclosure ; *Ethics, Medical ; Female ; Fetus/*physiology ; Humans ; Informed Consent ; Pregnancy ; *Risk Assessment
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    High anxiety over flights through ozone (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):767, 769.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462189" target="_blank"〉PubMed〈/a〉
    Keywords: *Aerospace Medicine ; Female ; Humans ; Male ; Occupational Diseases/*chemically induced ; Ozone/*poisoning
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Ethanol embryotoxicity: direct effects on mammalian embryos in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Temperature-dependent sex determination in turtles (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: The sex of hatchling map turtles is determined by incubation temperature of eggs in the laboratory as well as in nature. Temperature controls sex differentiation rather than causing a differential mortality of sexes. Temperature has no effect on sex determination in a soft-shelled turtle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Vogt, R C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genotype ; Male ; *Sex Determination Analysis ; Species Specificity ; Temperature ; Turtles/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    5-Bromodeoxyuridine inhibits sequence changes within inverted repeat DNA during embryogenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: Previous studies on the genome of Strongylocentrotus purpuratus sea urchin have shown that changes in the nucleotide sequence of inverted repeat sequences occur during embryogenesis. The present study indicates that these sequence changes fail to occur when the embryos are raised in the presence of 5-bromodeoxyuridine. This drug is an analog of thymidine, is incorporated into the DNA during embryogenesis, and inhibits cell differentiation in these embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickinson, D G -- Baker, R F -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):816-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence/*drug effects ; Bromodeoxyuridine/*pharmacology ; DNA Replication/*drug effects ; Female ; Ovum/*metabolism ; Sea Urchins
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Human chorionic gonadotropin: induction of ovulation in the squirrel monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dukelow, W R -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone/pharmacology ; Haplorhini/*physiology ; Ovulation/*drug effects ; Saimiri/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    To know with the nose: keys to odor identification (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: Successful odor identification depends on (i) commonly encountered substances, (ii) a long-standing connection between an odor and its name, and (iii) aid in recalling the name. The absence of any one ingredient impairs performance dramatically, but the presence of all three permits ready identification of scores of substances, with performance seemingly limited only by the inherent confusability of the stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cain, W S -- New York, N.Y. -- Science. 1979 Feb 2;203(4379):467-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760202" target="_blank"〉PubMed〈/a〉
    Keywords: Feedback ; Female ; Humans ; Memory/physiology ; Odors ; Smell/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Cyclic AMP receptor triggers nuclear protein phosphorylation in a hormone-dependent mammary tumor cell-free system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamide, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone-dependent mammary tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho-Chung, Y S -- Archibald, D -- Clair, T -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224463" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene ; Animals ; Cell Nucleus/metabolism ; Cell-Free System ; Chromosomal Proteins, Non-Histone/*metabolism ; Cyclic AMP/*metabolism ; Female ; Mammary Neoplasms, Experimental/*metabolism ; Neoplasm Proteins/metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Cyclic AMP/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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