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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    The journal of Fourier analysis and applications 5 (1999), S. 105-125 
    ISSN: 1531-5851
    Schlagwort(e): 26B05 ; 42B10 ; 42C99 ; frame ; Gabor system ; Riesz basis ; stability ; wavelet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract If the sequence of functions ϕj, k is a wavelet frame (Riesz basis) or Gabor frame (Riesz basis), we obtain its perturbation system ψj,k which is still a frame (Riesz basis) under very mild conditions. For example, we do not need to know that the support of ϕ or ψ $$(\hat \phi or\hat \psi )$$ is compact as in [14]. We also discuss the stability of irregular sampling problems. In order to arrive at some of our results, we set up a general multivariate version of Littlewood-Paley type inequality which was originally considered by Lemarié and Meyer [17], then by Chui and Shi [9], and Long [16].
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    OR spectrum 20 (1998), S. 101-107 
    ISSN: 1436-6304
    Schlagwort(e): Competitive location model ; Nash equilibria ; stability ; reachability ; Wettbewerbsmodelle in der Standorttheorie ; Nash Gleichgewicht ; Stabilität ; Erreichbarkeit
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik , Wirtschaftswissenschaften
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In der Arbeit werden die Standorte von Duopolisten in einem Baum untersucht. Unter der Annahme festgesetzter Preise werden notwendige und hinreichende Bedingungen für Nash Gleichgewichte für Standorte auf Bäumen hergeleitet. Unter Verwendung dieser Bedingungen wird dann gezeigt, daß — angenommen Nash Gleichgewichte existieren — diese in einem wiederholt angewandten sequentiellen Standortfindungsprozeß, in dem beide Duopolisten als Zielfunktion kurzfristige Gewinnmaximierung haben, auch erreicht werden.
    Notizen: Abstract This paper examines the location of duopolists on a tree. Given parametric prices, we first delineate necessary and sufficient conditions for locational Nash equilibria on trees. Given these conditions, we then show that Nash equilibria, provided they exist, can be reached in a repeated sequential relocation process in which both facilities follow short-term profit maximization objectives.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    OR spectrum 20 (1998), S. 101-107 
    ISSN: 1436-6304
    Schlagwort(e): Key words: Competitive location model ; Nash equilibria ; stability ; reachability ; Schlüsselwörter: Wettbewerbsmodelle in der Standorttheorie ; Nash Gleichgewicht ; Stabilität ; Erreichbarkeit
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik , Wirtschaftswissenschaften
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung. In der Arbeit werden die Standorte von Duopolisten in einem Baum untersucht. Unter der Annahme festgesetzter Preise werden notwendige und hinreichende Bedingungen für Nash Gleichgewichte für Standorte auf Bäumen hergeleitet. Unter Verwendung dieser Bedingungen wird dann gezeigt, daß– angenommen Nash Gleichgewichte existieren – diese in einem wiederholt angewandten sequentiellen Standortfindungsprozeß, in dem beide Duopolisten als Zielfunktion kurzfristige Gewinnmaximierung haben, auch erreicht werden. “Equilibrium is a place in heaven, but how do we get there from here?”
    Notizen: Abstract. This paper examines the location of duopolists on a tree. Given parametric prices, we first delineate necessary and sufficient conditions for locational Nash equilibria on trees. Given these conditions, we then show that Nash equilibria, provided they exist, can be reached in a repeated sequential relocation process in which both facilities follow short-term profit maximization objectives.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Empirical economics 23 (1998), S. 387-400 
    ISSN: 1435-8921
    Schlagwort(e): Key words: Money demand ; cointegration ; stability ; regime shift ; JEL classification: E41 ; C22
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Wirtschaftswissenschaften
    Notizen: Abstract. Using several tests for structural stability in regressions with I(1) variables and for the existence of cointegration in models with regime shifts, the empirical evidence on the existence of a structural break in the Spanish long-run demand for broad money (ALP2) is analysed.  The results indicate that shifts affecting the demand for ALP2 in recent years have substantially altered its long-run properties. As to the cause of this structural break, emphasis is placed on the role played by the increasing openness of the Spanish financial system to international markets as obstacles to free capital movements have progressively disappeared.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Stochastic environmental research and risk assessment 12 (1998), S. 191-204 
    ISSN: 1436-3259
    Schlagwort(e): Keywords: groundwater flow ; inverse problems ; stability ; geostatistical interpolation ; kriging.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Energietechnik , Geographie , Geologie und Paläontologie
    Notizen: Abstract The Differential System Method (DSM) permits identification of the physical parameters of finite-difference groundwater flow models in a confined aquifer when piezometric head and source terms are known at each point of the finite-difference lattice for at least two independent flow situations for which the hydraulic gradients are not parallel. Since piezometric head data are usually few and sparse, interpolation of the measured data onto a regular grid can be performed with geostatistical techniques. We apply kriging to the sparse data of a synthetic aquifer to evaluate the stability of the DSM with respect to uncorrelated measurement errors and interpolation errors. The numerical results show that the DSM is stable.
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  • 6
    ISSN: 1572-8358
    Schlagwort(e): Epidemiology ; sleeping sickness ; vector controls ; differential equations ; spacialization ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A compartmental model is described for the spread of Gambian sleeping sickness in a spatially heterogeneous environment in which vector and human populations migrate between two "patches": the village and the plantations. The number of equilibrium points depends on two "summary parameters": gr the proportion removed among human infectives, and R0, the basic reproduction number. The origin is stable for R0 〈1 and unstable for R0 〉1. Control strategies are assessed by studying the mix of vector control between the two patches that bring R0 below 1. The results demonstrate the importance of vector control in the plantations. For example if 20 percent of flies are in the village and the blood meal rate in the village is 10 percent, then a 20 percent added vector mortality in the village must be combined with a 9 percent added mortality in the plantations in order to bring R0 below 1. The results are quite insentive to the blood meal rate in the village. Optimal strategies (that minimize the total number of flies trapped in both patches) are briefly discussed.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Journal of dynamics and differential equations 10 (1998), S. 151-188 
    ISSN: 1572-9222
    Schlagwort(e): Fourth-order solitary waves ; stability ; instability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We study ground-state traveling wave solutions of a fourth-order wave equation. We find conditions on the speed of the waves which imply stability and instability of the solitary waves. The analysis depends on the variational characterization of the ground states rather than information about the linearized operator.
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  • 8
    ISSN: 1572-9281
    Schlagwort(e): asymptotic stability ; dichotomic maps ; retarded functional differential equation ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract This paper deals with the study of the stability of nonautonomous retarded functional differential equations using the theory of dichotomic maps. After some preliminaries, we prove the theorems on simple and asymptotic stability. Some examples are given to illustrate the application of the method. Main results about asymptotic stability of the equation $$x'(t) = - b(t)x(t - r)$$ and of itsnonlinear generalization $$x'(t) = b(t)f(x(t - r))$$ are established.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 29 (1998), S. 55-73 
    ISSN: 1572-9443
    Schlagwort(e): multi‐server queue ; customer class ; state‐dependent routing ; stability ; Markov chain ; fluid limit
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract We consider a multi‐station queue with a multi‐class input process when any station is available for the service of only some (not all) customer classes. Upon arrival, any customer may choose one of its accessible stations according to some state‐dependent policy. We obtain simple stability criteria for this model in two particular cases when service rates are either station‐ or class‐independent. Then, we study a two‐station queue under general assumptions on service rates. Our proofs are based on the fluid approximation approach.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 32 (1999), S. 131-168 
    ISSN: 1572-9443
    Schlagwort(e): stability ; positive recurrence ; fluid limit ; polling system ; exhaustive service policy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract We introduce a generalized criterion for the stability of Markovian queueing systems in terms of stochastic fluid limits. We consider an example in which this criterion may be applied: a polling system with two stations and two heterogeneous servers.
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Celestial mechanics and dynamical astronomy 74 (1999), S. 19-57 
    ISSN: 1572-9478
    Schlagwort(e): stability ; Hamiltonian ; two centers ; oblate planet ; galactic disks ; dipole
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Relative equilibria occur in a wide variety of physical applications, including celestial mechanics, particle accelerators, plasma physics, and atomic physics. We derive sufficient conditions for Lyapunov stability of circular orbits in arbitrary axisymmetric gravitational (electrostatic) and magnetic fields, including the effects of local mass (charge) and current density. Particularly simple stability conditions are derived for source‐free regions, where the gravitational field is harmonic (∇2U = 0) or the magnetic field irrotational (∇ × B = 0). In either case the resulting stability conditions can be expressed geometrically (coordinate‐free) in terms of dimensionless stability indices. Stability bounds are calculated for several examples, including the problem of two fixed centers, the J2 planetary model, galactic disks, and a toroidal quadrupole magnetic field.
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  • 12
    Digitale Medien
    Digitale Medien
    Springer
    Celestial mechanics and dynamical astronomy 75 (1999), S. 251-285 
    ISSN: 1572-9478
    Schlagwort(e): unrestricted problem ; rotational motion ; rigid body dynamics ; libration points ; stability ; resonances
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We present an analysis of the model introduced by Kokoriev and Kirpichnikov (1988) for the study of unrestricted planar motion of a point mass and a symmetric rigid body whose gravity field is approximated by two point masses (a dumb-bell model). To show possible generalization of the model, we give a systematic derivation of equations of motion for a more general unrestricted problem of a point and a rigid body possessing a plane of dynamical symmetry. We give a simple description of bifurcation of triangular libration points, and we perform an analysis of their linear stability. We propose to extend the model of Kokoriev and Kirpichnikov (1988) to a case when the symmetric body is oblate. In the proposed model the gravity field of moving and rotating body is approximated by two complex masses at complex distance (a complex dumb-bell model). An analysis of bifurcation of the triangular libration points in this model is also presented.
    Materialart: Digitale Medien
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  • 13
    Digitale Medien
    Digitale Medien
    Springer
    Computational & mathematical organization theory 5 (1999), S. 5-30 
    ISSN: 1572-9346
    Schlagwort(e): network models ; organization theory ; rule following ; self organized ; stability ; work teams ; work routine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Self-organized rule-following systems are increasingly relevant objects of study in organization theory due to such systems&2018; capacity to maintain control while enabling decentralization of authority. This paper proposes a network model for such systems and examines the stability of the networks&2018; repetitive behavior. The networks examined are Ashby nets, a fundamental class of binary systems: connected aggregates of nodes that individually compute an interaction rule, a binary function of their three inputs. The nodes, which we interpret as workers in a work team, have two network inputs and one self-input. All workers in a given team follow the same interaction rule. We operationalize the notion of stability of the team&2018;s work routine and determine stability under small perturbations for all possible rules these teams can follow. To study the organizational concomitants of stability, we characterize the rules by their memory, fluency, homogeneity, and autonomy. We relate these measures to work routine stability, and find that stability in ten member teams is enhanced by rules that have low memory, high homogeneity, and low autonomy.
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 28 (1998), S. 33-54 
    ISSN: 1572-9443
    Schlagwort(e): queueing networks ; throughput ; closed networks ; efficiency ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract A closed network is said to be “guaranteed efficient” if the throughput converges under all non-idling policies to the capacity of the bottlenecks in the network, as the number of trapped customers increases to infinity. We obtain a necessary condition for guaranteed efficiency of closed re-entrant lines. For balanced two-station systems, this necessary condition is almost sufficient, differing from it only by the strictness of an inequality. This near characterization is obtained by studying a special type of virtual station called “alternating visit virtual station”. These special virtual stations allow us to relate the necessary condition to certain indices arising in heavy traffic studies using a Brownian network approximation, as well as to certain policies proposed as being extremal with respect to the asymptotic loss in the throughput. Using the near characterization of guaranteed efficiency we also answer the often pondered question of whether an open network or its closed counterpart has greater throughput - the answer is that neither can assure a greater guaranteed throughput.
    Materialart: Digitale Medien
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 33 (1999), S. 293-325 
    ISSN: 1572-9443
    Schlagwort(e): stability ; fluid models ; multiclass queueing networks ; piecewise linear Lyapunov functions ; linear Lyapunov functions ; monotone global stability ; static buffer priority disciplines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract This paper studies the stability of a three‐station fluid network. We show that, unlike the two‐station networks in Dai and Vande Vate [18], the global stability region of our three‐station network is not the intersection of its stability regions under static buffer priority disciplines. Thus, the “worst” or extremal disciplines are not static buffer priority disciplines. We also prove that the global stability region of our three‐station network is not monotone in the service times and so, we may move a service time vector out of the global stability region by reducing the service time for a class. We introduce the monotone global stability region and show that a linear program (LP) related to a piecewise linear Lyapunov function characterizes this largest monotone subset of the global stability region for our three‐station network. We also show that the LP proposed by Bertsimas et al. [1] does not characterize either the global stability region or even the monotone global stability region of our three‐station network. Further, we demonstrate that the LP related to the linear Lyapunov function proposed by Chen and Zhang [11] does not characterize the stability region of our three‐station network under a static buffer priority discipline.
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Set-valued analysis 7 (1999), S. 209-238 
    ISSN: 1572-932X
    Schlagwort(e): nonsmooth analysis ; subdifferentials ; coderivatives ; implicit function theorem ; solvability ; stability ; open mapping theorem ; metric regularity ; multidirectional mean value inequality
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We prove a general implicit function theorem for multifunctions with a metric estimate on the implicit multifunction and a characterization of its coderivative. Traditional open covering theorems, stability results, and sufficient conditions for a multifunction to be metrically regular or pseudo-Lipschitzian can be deduced from this implicit function theorem. We prove this implicit multifunction theorem by reducing it to an implicit function/solvability theorem for functions. This approach can also be used to prove the Robinson–Ursescu open mapping theorem. As a tool for this alternative proof of the Robinson–Ursescu theorem, we also establish a refined version of the multidirectional mean value inequality which is of independent interest.
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 29 (1998), S. 129-159 
    ISSN: 1572-9443
    Schlagwort(e): rate-based feedback control ; ATM networks ; stability ; optimal algorithms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract Motivated by ABR class of service in ATM networks, we study a continuous time queueing system with a feedback control of the arrival rate of some of the sources. The feedback about the queue length or the total workload is provided at regular intervals (variations on it, especially the traffic management specification TM 4.0, are also considered). The propagation delays can be nonnegligible. For a general class of feedback algorithms, we obtain the stability of the system in the presence of one or more bottleneck nodes in the virtual circuit. Our system is general enough that it can be useful to study feedback control in other network protocols. We also obtain rates of convergence to the stationary distributions and finiteness of moments. For the single botterneck case, we provide algorithms to compute the stationary distributions and the moments of the sojourn times in different sets of states. We also show analytically (by showing continuity of stationary distributions and moments) that for small propagation delays, we can provide feedback algorithms which have higher mean throughput, lower probability of overflow and lower delay jitter than any open loop policy. Finally these results are supplemented by some computational results.
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 31 (1999), S. 171-206 
    ISSN: 1572-9443
    Schlagwort(e): scheduling ; open multiclass queueing networks ; discrete-review policies ; fluid models ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract This paper describes a family of discrete-review policies for scheduling open multiclass queueing networks. Each of the policies in the family is derived from what we call a dynamic reward function: such a function associates with each queue length vector q and each job class k a positive value r k (q), which is treated as a reward rate for time devoted to processing class k jobs. Assuming that each station has a traffic intensity parameter less than one, all policies in the family considered are shown to be stable. In such a policy, system status is reviewed at discrete points in time, and at each such point the controller formulates a processing plan for the next review period, based on the queue length vector observed. Stability is proved by combining elementary large deviations theory with an analysis of an associated fluid control problem. These results are extended to systems with class dependent setup times as well as systems with alternate routing and admission control capabilities.
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  • 19
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 32 (1999), S. 99-130 
    ISSN: 1572-9443
    Schlagwort(e): neural network ; inhibition ; stability ; Markov process ; fluid limit ; Harris-recurrence ; transience
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract The subject of the paper is the stability analysis of some neural networks consisting of a finite number of interacting neurons. Following the approach of Dai [5] we use the fluid limit model of the network to derive a sufficient condition for positive Harris-recurrence of the associated Markov process. This improves the main result in Karpelevich et al. [11] and, at the same time, sheds some new light on it. We further derive two different conditions that are sufficient for transience of the state process and illustrate our results by classifying some examples according to positive recurrence or transience.
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  • 20
    Digitale Medien
    Digitale Medien
    Springer
    Queueing systems 32 (1999), S. 195-231 
    ISSN: 1572-9443
    Schlagwort(e): window flow control ; TCP ; stability ; multiclass networks ; stationary ergodic point processes ; (max,+)-linear system
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract We focus on window flow control as used in packet-switched communication networks. The approach consists in studying the stability of a system where each node on the path followed by the packets of the controlled connection is modeled by a FIFO (First-In-First-Out) queue of infinite capacity which receives in addition some cross traffic represented by an exogenous flow. Under general stochastic assumptions, namely for stationary and ergodic input processes, we show the existence of a maximum throughput allowed by the flow control. Then we establish bounds on the value of this maximum throughput. These bounds, which do not coincide in general, are reached by time-space scalings of the exogenous flows. Therefore, the performance of the window flow control depends not only on the traffic intensity of the cross flows, but also on fine statistical characteristics such as the burstiness of these flows. These results are illustrated by several examples, including the case of a nonmonotone, nonconvex and fractal stability region.
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  • 21
    Digitale Medien
    Digitale Medien
    Springer
    Advances in computational mathematics 10 (1999), S. 271-289 
    ISSN: 1572-9044
    Schlagwort(e): delay differential equations ; steady state solutions ; stability ; 34K20 ; 65J10
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The characteristic equation of a system of delay differential equations (DDEs) is a nonlinear equation with infinitely many zeros. The stability of a steady state solution of such a DDE system is determined by the number of zeros of this equation with positive real part. We present a numerical algorithm to compute the rightmost, i.e., stability determining, zeros of the characteristic equation. The algorithm is based on the application of subspace iteration on the time integration operator of the system or its variational equations. The computed zeros provide insight into the system’s behaviour, can be used for robust bifurcation detection and for efficient indirect calculation of bifurcation points.
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  • 22
    Digitale Medien
    Digitale Medien
    Springer
    BIT 39 (1999), S. 385-402 
    ISSN: 1572-9125
    Schlagwort(e): Gaussian elimination ; stability ; backward error analysis ; growth factor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract A new backward error analysis of LU factorization is presented. It allows to obtain a sharper upper bound for the forward error and a new definition of the growth factor that we compare with the well known Wilkinson growth factor for some classes of matrices. Numerical experiments show that the new growth factor is often of order approximately log2 n whereas Wilkinson's growth factor is of order n or $$\sqrt n$$ .
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  • 23
    Digitale Medien
    Digitale Medien
    Springer
    Advances in computational mathematics 9 (1998), S. 145-171 
    ISSN: 1572-9044
    Schlagwort(e): periodic pseudodifferential equations ; multiwavelets ; splines with multiple knots ; generalized Galerkin–Petrov schemes ; boundary element methods ; error analysis ; stability ; Strang–Fix condition ; 65J10 ; 65N30 ; 65N35 ; 65R20 ; 47G30 ; 45P05 ; 41A25 ; 41A30 ; 41A15
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We develop a stability and convergence analysis of Galerkin–Petrov schemes based on a general setting of multiresolution generated by several refinable functions for the numerical solution of pseudodifferential equations on smooth closed curves. Particular realizations of such a multiresolution analysis are trial spaces generated by biorthogonal wavelets or by splines with multiple knots. The main result presents necessary and sufficient conditions for the stability of the numerical method in terms of the principal symbol of the pseudodifferential operator and the Fourier transforms of the generating multiscaling functions as well as of the test functionals. Moreover, optimal convergence rates for the approximate solutions in a range of Sobolev spaces are established.
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  • 24
    Digitale Medien
    Digitale Medien
    Springer
    Advances in computational mathematics 10 (1999), S. 115-133 
    ISSN: 1572-9044
    Schlagwort(e): Runge–Kutta–Nyström methods ; predictor–corrector methods ; stability ; parallelism ; 65M12 ; 65M20
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract This paper describes the construction of block predictor–corrector methods based on Runge–Kutta–Nyström correctors. Our approach is to apply the predictor–corrector method not only with stepsize h, but, in addition (and simultaneously) with stepsizes a i h, i = 1 ...,r. In this way, at each step, a whole block of approximations to the exact solution at off‐step points is computed. In the next step, these approximations are used to obtain a high‐order predictor formula using Lagrange or Hermite interpolation. Since the block approximations at the off‐step points can be computed in parallel, the sequential costs of these block predictor–corrector methods are comparable with those of a conventional predictor–corrector method. Furthermore, by using Runge–Kutta–Nyström corrector methods, the computation of the approximation at each off‐step point is also highly parallel. Numerical comparisons on a shared memory computer show the efficiency of the methods for problems with expensive function evaluations.
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  • 25
    Digitale Medien
    Digitale Medien
    Springer
    Celestial mechanics and dynamical astronomy 70 (1998), S. 41-58 
    ISSN: 1572-9478
    Schlagwort(e): three-body problem ; libration points ; stability ; normal forms.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract In this paper we consider the problem of motion of an infinitesimal point mass in the gravity field of an uniformly rotating dumb-bell. The aim of our study is to investigate Liapunov stability of Lagrangian libration points of this problem. We analyze the stability of libration points in the whole range of parameters ω, μ of the problem. In particular, we consider all resonance cases when the order of resonance is not greater than five.
    Materialart: Digitale Medien
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  • 26
    Digitale Medien
    Digitale Medien
    Springer
    BIT 39 (1999), S. 620-645 
    ISSN: 1572-9125
    Schlagwort(e): Numerical integrator ; oscillatory solutions ; Schrödinger equation ; quantum-classical coupling ; error bounds ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We study time integration methods for equations of mixed quantum-classical molecular dynamics in which Newtonian equations of motion and Schrödinger equations are nonlinearly coupled. Such systems exhibit different time scales in the classical and the quantum evolution, and the solutions are typically highly oscillatory. The numerical methods use the exponential of the quantum Hamiltonian whose product with a state vector is approximated using Lanczos' method. This allows time steps that are much larger than the inverse of the highest frequencies. We describe various integration schemes and analyze their error behaviour, without assuming smoothness of the solution. As preparation and as a problem of independent interest, we study also integration methods for Schrödinger equations with time-dependent Hamiltonian.
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  • 27
    Digitale Medien
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    Optical review 6 (1999), S. 28-36 
    ISSN: 1349-9432
    Schlagwort(e): optical propagation equation ; stability ; picosecond pulse ; 3-dimensional computation ; Fresnel’s distribution ; fast Fourier transform
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We present a new simulation code able to simulate the entire propagation of laser pulse, from the amplifiers level up to the focusing stage. This algorithm has some new characteristics that we intend to present. It computes the three-dimensional optical propagation equation using no approximation other than its picosecond expression. The stability has been carefully studied so that it can be applied to any geometry. This is a great improvement since, up to now only cylindrical geometry was accessible for accuracy. In this paper we also present a method using Fast Fourier Transform able to evaluate with a high accuracy, Fresnel’s distribution of a focused laser pulse. The advantages provided by our algorithm are its rapidity and its high physical understanding of the focusing phenomena.
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  • 28
    Digitale Medien
    Digitale Medien
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    Monatshefte für Mathematik 126 (1998), S. 117-124 
    ISSN: 1436-5081
    Schlagwort(e): 52A20 ; 52A22 ; star bodies ; spherical integral transformations ; convex bodies ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract LetK be ad-dimensional star body (with respect to the origino). It is known that the (d−1)-dimensional volume of the intersections ofK with the hyperplanes througho does not uniquely determineK. Uniqueness can only be achieved under additional assumptions, such as central symmetry. Here it is pointed out that if one uses, instead of intersections by hyperplanes, intersections by half-planes that containo on the boundary, then, without any additional assumptions, the volume of these intersections determinesK uniquely. This assertion, and more general results of this kind, together with stability estimates, are obtained from uniqueness results and estimates concerning a particular spherical integral transformation.
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  • 29
    Digitale Medien
    Digitale Medien
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    Catalysis letters 53 (1998), S. 97-101 
    ISSN: 1572-879X
    Schlagwort(e): ethene hydroformylation ; heterogeneous catalysts ; cobalt catalysts ; gas‐phase deposition ; dispersion ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The results from ethene hydroformylation at 173°C showed that a Co(acac)3/SiO2 catalyst prepared from Co(acac)3 precursor by gas‐phase deposition was three times as active as a catalyst prepared by impregnation from cobalt nitrate, but oxo‐selectivities were similar. The high propanal selectivities on the Co(acac)3/SiO2 seem to be related to the presence of highly dispersed active sites favouring CO insertion. As dispersion is decreased from 23 to 8% due to increasing metal content (from 5 to 16 wt%), oxo‐selectivity decreased from 39 to 25%. The activity of Co(acac)3/SiO2 remained unchanged during 68 h on stream. The gas‐phase deposition technique described here is a promising method for the preparation of active, selective and stable heterogeneous hydroformylation catalysts.
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  • 30
    ISSN: 1572-879X
    Schlagwort(e): nanolithography ; model catalyst ; palladium ; copper ; stability ; spin-coating ; SEM ; AFM ; XPS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Metal clusters arranged on nanostructured oxidized silicon wafers are presented as new model catalyst systems. A photoresist layer spun on top of a wafer was patterned by laser interference exposure. The grid obtained after removing the exposed parts of the resist is used as an etching mask. Hollows with diameters of 300 nm and depths between 50 and 60 nm were etched into the oxide layer using wet chemical methods. Two methods were applied to deposit metal clusters (Pd or Cu) in a defined way within the hollows. The particles ranged from 10 to 50 nm in height and from 80 to 200 nm in diameter. The model catalyst systems were characterized by atomic force microscopy and X-ray photoelectron spectroscopy. The method presented here allows us to produce 4 inch wafers that are covered completely by nanometer-sized structures in a reasonable period of time.
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  • 31
    Digitale Medien
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    Archive of applied mechanics 69 (1999), S. 47-54 
    ISSN: 1432-0681
    Schlagwort(e): Key words Bifurcation ; stability ; multibody system dynamics ; singularity theory ; Liapunov's direct method
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Summary In this paper, the global behavior of relative equilibrium states of a three-body satellite with flexible connection under the action of the gravitational torque is studied. With geometric method, the conditions of existence of nontrivial solutions to the relative equilibrium equations are determined. By using reduction method and singularity theory, the conditions of occurrence of bifurcation from trivial solutions are derived, which agree with the existence conditions of nontrivial solutions, and the bifurcation is proved to be pitchfork-bifurcation. The Liapunov stability of each equilibrium state is considered, and a stability diagram in terms of system parameters is presented.
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  • 32
    Digitale Medien
    Digitale Medien
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    Journal of intelligent and robotic systems 23 (1998), S. 27-43 
    ISSN: 1573-0409
    Schlagwort(e): autonomous control ; actuator delays ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik , Maschinenbau
    Notizen: Abstract In this paper, we consider the control design problem of vehicle following systems with actuator delays. An upper bound for the time delays is first constructed to guarantee the vehicle stability. Second, sufficient conditions are presented to avoid slinky-effects in the vehicle following. Next, zero steady state achieved by the proposed controller is proven. Finally, simulations are given to examine our claims.
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  • 33
    Digitale Medien
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    Journal of productivity analysis 12 (1999), S. 55-75 
    ISSN: 1573-0441
    Schlagwort(e): Data envelopment analysis (DEA) ; returns to scale (RTS) ; sensitivity ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Wirtschaftswissenschaften
    Notizen: Abstract Sensitivity of the returns to scale (RTS) classifications in data envelopment analysis is studied by means of linear programming problems. The stability region for an observation preserving its current RTS classification (constant, increasing or decreasing returns to scale) can be easily investigated by the optimal values to a set of particular DEA-type formulations. Necessary and sufficient conditions are determined for preserving the RTS classifications when input or output data perturbations are non-proportional. It is shown that the sensitivity analysis method under proportional data perturbations can also be used to estimate the RTS classifications and discover the identical RTS regions yielded by the input-based and the output-based DEA methods. Thus, our approach provides information on both the RTS classifications and the stability of the classifications. This sensitivity analysis method can easily be applied via existing DEA codes.
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  • 34
    Digitale Medien
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    Agroforestry systems 45 (1999), S. 131-158 
    ISSN: 1572-9680
    Schlagwort(e): competition ; fertility ; microclimate ; risk ; stability ; water
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract The first ecosystem mimic hypothesis suggests clear advantages if man-made land use systems do not deviate greatly in their resource use patterns from natural ecosystems typical of a given climatic zone. The second hypothesis claims that additional advantages will accrue if agroecosystems also maintain a substantial part of the diversity of natural systems. We test these hypotheses for the savannah zone of sub-Saharan Africa, with its low soil fertility and variable rainfall. Where annual food crops replace the natural grass understorey of savannah systems, water use will decrease and stream and groundwater flow change, unless tree density increases relative to the natural situation. Increasing tree density, however, will decrease crop yields, unless the trees meet specific criteria. Food crop production in the parkland systems may benefit from lower temperatures under tree canopies, but water use by trees providing this shade will prevent crops from benefiting. In old parkland trees that farmers have traditionally retained when opening fields for crops, water use per unit shade is less than in most fast growing trees introduced for agroforestry trials. Strong competition between plants adapted to years with different rainfall patterns may stabilise total system productivity -- but this will be appreciated by a farmer only if the components are of comparable value. The best precondition for farmers to maintain diversity in their agroecosystem hinges on the availability of a broad basket of choices, without clear winners or 'best bets'.
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  • 35
    Digitale Medien
    Digitale Medien
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    Journal of statistical physics 91 (1998), S. 285-305 
    ISSN: 1572-9613
    Schlagwort(e): Chapman–Enskog expansion ; Burnett equation ; Boltzmann equation ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract This paper continues the author's study of procedures for rewriting the well-known Chapman–Enskog expansion used in the kinetic theory of gases. The usual Chapman–Enskog expansion, when used in isothermal fluid motion, will introduce nonlinear instability at super-Burnett order O(ε3) truncation. The procedure given here eliminates the truncation instability and produces the desired dissipation inequality.
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  • 36
    Digitale Medien
    Digitale Medien
    Springer
    Journal of statistical physics 95 (1999), S. 835-850 
    ISSN: 1572-9613
    Schlagwort(e): quasicrystals ; nonperiodic tilings ; classical lattice-gas models ; nonperiodic ground states ; nonperiodic Gibbs states ; stability ; frustration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract One of the fundamental problems of quasicrystals is to understand their occurrence in microscopic models of interacting particles. We review here recent attempts to construct stable quasicrystalline phases. In particular, we compare two recently constructed classical lattice-gas models with translation-invariant interactions and without periodic ground-state configurations. The models are based on nonperiodic tilings of the plane by square-like tiles. In the first model, all interactions can be minimized simultaneously. The second model is frustrated; its nonperiodic ground state can arise only by the minimization of the energy of competing interactions. We put forward some hypotheses concerning stabilities of nonperiodic ground states. In particular, we introduce two criteria, the so-called strict boundary conditions, and prove their equivalence to the zero-temperature stability of ground states against small perturbations of potentials of interacting particles. We discuss the relevance of these conditions for the low-temperature stability, i.e., for the existence of thermodynamically stable nonperiodic equilibrium states.
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  • 37
    Digitale Medien
    Digitale Medien
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    Journal of statistical physics 95 (1999), S. 867-902 
    ISSN: 1572-9613
    Schlagwort(e): kinetics of phase transitions ; domain coarsening ; asymptotic behavior ; self-similarity ; stability ; chaos
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The classical Lifshitz–Slyozov–Wagner theory of domain coarsening predicts asymptotically self-similar behavior for the size distribution of a dilute system of particles that evolve by diffusional mass transfer with a common mean field. Here we consider the long-time behavior of measure-valued solutions for systems in which particle size is uniformly bounded, i.e., for initial measures of compact support. We prove that the long-time behavior of the size distribution depends sensitively on the initial distribution of the largest particles in the system. Convergence to the classically predicted smooth similarity solution is impossible if the initial distribution function is comparable to any finite power of distance to the end of the support. We give a necessary criterion for convergence to other self-similar solutions, and conditional stability theorems for some such solutions. For a dense set of initial data, convergence to any self-similar solution is impossible.
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  • 38
    Digitale Medien
    Digitale Medien
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    Journal of intelligent and robotic systems 22 (1998), S. 23-38 
    ISSN: 1573-0409
    Schlagwort(e): robot dynamic model ; stiffness matrix ; constant disturbance ; integrator backstepping ; Liapunov functions ; Barbalat lemma ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik , Maschinenbau
    Notizen: Abstract A robust regulator for flexible-joint robots is proposed, which yields constant torque disturbance rejection acting on the links. The design uses the integrator backstepping technique [4,5] to cancel nonlinearities and disturbance not in the range space of the control. Stability of the closed loop system is shown using iterative Liapunov functions.
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  • 39
    Digitale Medien
    Digitale Medien
    Springer
    Journal of intelligent and robotic systems 26 (1999), S. 91-100 
    ISSN: 1573-0409
    Schlagwort(e): robots ; neural networks ; adaptiveness ; stability ; approximation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik , Maschinenbau
    Notizen: Abstract An indirect adaptive control approach is developed in this paper for robots with unknown nonlinear dynamics using neural networks (NNs). A key property of the proposed approach is that the actual joint angle values in the control law are replaced by the desired joint angles, angle velocities and accelerators, and the bound on the NN reconstruction errors is assumed to be unknown. Main theoretical results for designing such a neuro-controller are given, and the control performance of the proposed controller is verified with simulation studies.
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  • 40
    Digitale Medien
    Digitale Medien
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    Biological cybernetics 81 (1999), S. 211-225 
    ISSN: 1432-0770
    Schlagwort(e): Key words: Hebbian learning rule ; attractor dynamics ; symmetric connections ; multiplicative normalization ; self-organization ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Informatik , Physik
    Notizen: Abstract. While learning and development are well characterized in feedforward networks, these features are more difficult to analyze in recurrent networks due to the increased complexity of dual dynamics – the rapid dynamics arising from activation states and the slow dynamics arising from learning or developmental plasticity. We present analytical and numerical results that consider dual dynamics in a recurrent network undergoing Hebbian learning with either constant weight decay or weight normalization. Starting from initially random connections, the recurrent network develops symmetric or near-symmetric connections through Hebbian learning. Reciprocity and modularity arise naturally through correlations in the activation states. Additionally, weight normalization may be better than constant weight decay for the development of multiple attractor states that allow a diverse representation of the inputs. These results suggest a natural mechanism by which synaptic plasticity in recurrent networks such as cortical and brainstem premotor circuits could enhance neural computation and the generation of motor programs.
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  • 41
    Digitale Medien
    Digitale Medien
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    Computational mechanics 23 (1999), S. 8-19 
    ISSN: 1432-0924
    Schlagwort(e): Keywords: Material characteristic length ; strain-rate gradient ; dominant growth rate ; viscoplastic material ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract We study thermomechanical deformations of a viscoplastic body deformed in simple shear. The strain gradients are taken as independent kinematic variables and the corresponding higher order stresses are included in the balance laws, and the equation for the yield surface. Three different functional relationships, the power law, and those proposed by Wright and Batra, and Johnson and Cook are used to relate the effective strain rate to the effective stress and temperature. Effects of strain hardening of the material and elastic deformations are neglected. The homogeneous solution of the problem is perturbed and the stability of the problem linear in the perturbation variables is studied. Following Wright and Ockendon's postulate that the wavelength whose initial growth rate is maximum determines the minimum spacing between adjacent shear bands, the shear band spacing is computed. It is found that the minimum shear band spacing is very sensitive to the thermal softening coefficient/exponent, the material characteristic length and the nominal strain-rate. Approximate analytical expressions for the critical wave length for heat conducting nonpolar materials and locally adiabatic deformations of gradient dependent materials are also derived.
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  • 42
    Digitale Medien
    Digitale Medien
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    Journal of thermal analysis and calorimetry 56 (1999), S. 1285-1304 
    ISSN: 1572-8943
    Schlagwort(e): amorphous state ; combined techniques ; drug design ; drug product development ; drug substance ; drug technology ; DSC ; excipients ; failure investigations ; hydrates ; MDSC ; microcalorimetry ; pharmaceuticals ; polymorphism ; polymers ; preformulation ; process optimization ; purity ; quality control ; solvates ; stability ; sub-ambient DSC ; TG ; temperature resolved X-ray diffraction ; water interactions ; thermal microscopy ; water sorption-desorption
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Modern thermal analysis, microcalorimetry and new emerging combined techniques which deliver calorimetric, microscopic and spectroscopic data offer a powerful analytical battery for the study of pharmaceuticals. These techniques are very useful in all steps of development of new drug products as well as methods for quality control in production. The characterization of raw materials enables to understand the relationships between polymorphs, solvates and hydrates and to choose the proper development of new drug products with very small amount of material in a very short time. Information on stability, purity is valuable for new entities as well as for marketed drug substances from different suppliers. Excipients which vary from single organic or inorganic entity to complexes matrixes or polymers need to be characterized and properly controlled. The thermodynamic phase-diagrams are the basis of the studies of drug-excipients interactions. They are very useful for the development of new delivery systems. A great number of new formulations need proper knowledge of the behaviour of the glass transition temperature of the components. Semi-liquid systems, interactions in aqueous media are also successfully studied by these techniques.
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  • 43
    Digitale Medien
    Digitale Medien
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    Journal of thermal analysis and calorimetry 55 (1999), S. 727-739 
    ISSN: 1572-8943
    Schlagwort(e): ignition ; polymer combustion modelling ; stability ; steady state
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A mathematical model of ignition and burning of organic polymers was used for evaluation and quantification of the tendency of polymers to ignition. The model permits investigation of the influence of one parameter of the polymer on the others. It was found that the model could be used for the verification of the ignitability method developed by Miller et al. [1]. Different steady states of combustion were found when using the model proposed. There is a characteristic steady state for normal flaming combustion, another for non-flaming combustion, and there are also unstable steady states that have no real physical meaning.
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  • 44
    Digitale Medien
    Digitale Medien
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    Journal of thermal analysis and calorimetry 56 (1999), S. 1177-1184 
    ISSN: 1572-8943
    Schlagwort(e): differential scanning calorimetry ; DNA triple helix ; oligonucleotides ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract In this work we report a thermodynamic characterization of stability and melting behaviour of two 24-mer DNA triplexes. The third strand, that binds the Watson-Crick double helix with Hoogsteen hydrogen bonds, contains 3′-3′ phosphodiester junction that determines the polarity inversion. The target double helix is composed of adjacent and alternate fragments of oligopurine-oligopyrimidine tracts. The two helices differ from the substitution of the cytosine, involved in the junction, with the thymine. Calorimetric data reported here provide a quantitative measure of the influence of pH and base modification on the stability of a DNA triplex.
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  • 45
    ISSN: 1572-9036
    Schlagwort(e): (discrete-time) Markov control processes ; expected total cost ; value iteration ; policy iteration ; stability ; transient control models
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract This paper studies the expected total cost (ETC) criterion for discrete-time Markov control processes on Borel spaces, and possibly unbounded cost-per-stage functions. It presents optimality results which include conditions for a control policy to be ETC-optimal and for the ETC-value function to be a solution of the dynamic programming equation. Conditions are also given for the ETC-value function to be the limit of the α-discounted cost value function as α ↑ 1, and for the Markov control process to be `stable" in the sense of Lagrange and almost surely. In addition, transient control models are fully analized. The paper thus provides a fairly complete, up-dated, survey-like presentation of the ETC criterion for Markov control processes on Borel spaces.
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  • 46
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    Digitale Medien
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    Environmental and resource economics 11 (1998), S. 503-520 
    ISSN: 1573-1502
    Schlagwort(e): biodiversity ; dynamics ; resilience ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Wirtschaftswissenschaften
    Notizen: Abstract The ecological concept of resilience has begun to inform analysis of change in economy-environment systems. The linkages between resilience and the stability of dynamical systems are discussed, along with its role in understanding of the evolution of such systems. Particular linkages discussed include those between resilience, biodiversity and the sustainability of alternative states. Recent developments in modelling the resilience of joint economy-environment systems suggest the advantages of analysing change in the system as a Markov process, the transition probabilities between states offering a natural measure of the resilience of the system in such states. It is argued that this ‘emergent property’ of the collaboration between ecology and economics has far-reaching implications for the way we think about, model and manage the environmental sustainability of economic development.
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  • 47
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    Journal of biomolecular NMR 13 (1999), S. 187-191 
    ISSN: 1573-5001
    Schlagwort(e): alignment ; bicelle ; dipolar coupling ; liquid crystal ; pH ; stability ; ubiquitin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract It is demonstrated that mixtures of ditetradecyl- phosphatidylcholine or didodecyl-phoshatidylcholine and dihexyl- phosphatidylcholine in water form lyotropic liquid crystalline phases under similar conditions as previously reported for bicelles consisting of dimyristoyl-phosphatidylcholine (DMPC) and dihexanoyl- phosphatidylcholine (DHPC). The carboxy-ester bonds present in DMPC and DHPC are replaced by ether linkages in their alkyl analogs, which prevents acid- or base-catalyzed hydrolysis of these compounds. 15N-1H dipolar couplings measured for ubiquitin over the 2.3–10.4pH range indicate that this protein retains a backbone conformation which is very similar to its structure at pH 6.5 over this entire range.
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  • 48
    Digitale Medien
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    Acta mechanica Sinica 14 (1998), S. 274-282 
    ISSN: 1614-3116
    Schlagwort(e): time delay ; stability ; frozen time approach ; retarded dynamic systems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract By means of the frozen time approach and the Kronecker product, two criteria of asymptotic stability are derived for the linear, time variant dynamic systems with either short time delays or with weak feedback involving arbitrary time delays, respectively. It is found that the asymptotic stability of these retarded dynamic systems is governed by the maximal and minimal singular values of the coefficient matrices and their time derivatives.
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  • 49
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    Digitale Medien
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    Acta mechanica Sinica 14 (1998), S. 226-233 
    ISSN: 1614-3116
    Schlagwort(e): jet ; stability ; dispersion equation ; swirling gas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Based on the linear analysis of stability, a dispersion equation is deduced which delineates the evolution of a general 3-dimensional disturbance on the free surface of an incompressible viscous liquid jet injected into a gas with swirl. Here, the dimensionless parameterJ e is again introduced, in the meantime, another dimensionless parameterE called as circulation is also introduced to represent the relative swirling intensity. With respect to the spatial growing disturbance mode, the numerical results obtained from solving the dispersion equation reveal the following facts. First, at the same value ofE, in pace with the changing ofJ e , the variation of disturbance and the critical disturbance mode still keep the same characters. Second, the present results are the same as that of S.P. Lin whenJ e 〉1; but in the range ofJ e 〈1, it's no more the case, the swirl decreases the axisymmetric disturbance, yet increases the asymmetric disturbance, furthermore the swirl may make the character of the most unstable disturbance mode changed (axisymmetric or asymmetric); the above action of the swirl becomes much stronger whenJ e ≪1.
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  • 50
    ISSN: 1573-5125
    Schlagwort(e): Chironomidae ; interspecific competition ; streams ; stability ; succession
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract New streams formed following ice recession in Glacier Bay National Park, southeastern Alaska allow insights into the role of abiotic and biotic interactions in the assemblage of benthic communities. Reductions in abundance of a pioneer chironomid colonizer, Diamesa alpina/lupus, in one new stream, Wolf Point Creek, is considered to be a result of competitive interactions with subsequent colonizers, as opposed to intolerance of warmer water temperature as previously suggested. Reduced densities of potential competitors (25–50 larvae per 500 cm2) in a cobble transplant experiment between streams, allowed persistence of D. alpina/lupus at low densities. In addition, significantly more D. alpina/lupus larvae emigrated from artificial stream channels containing other chironomid taxa than channels without potential competitors while there was no significant correlation of emigration with water temperature. A small number of D. alpina/lupus transplanted from a cold stream (4–6 °C) survived at water temperatures of 10–15 °C for 1 week. These results infer that interference competition is the causal mechanism in the decline of D. alpina/lupus. Complete exclusion of D. alpina/lupus from the stream has not occurred and water temperature may play a role in partitioning D. alpina/lupus from other taxa on a temporal or a spatial basis.
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  • 51
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    Biology and philosophy 13 (1998), S. 541-554 
    ISSN: 1572-8404
    Schlagwort(e): complex natural system ; stability ; evolvability ; decomposable hierarchy ; genetic network ; Random NK Boolean Network
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Philosophie
    Notizen: Abstract I criticize Herbert Simon's argument for the claim that complex natural systems must constitute decomposable, mereological or functional hierarchies. The argument depends on certain assumptions about the requirements for the successful evolution of complex systems, most importantly, the existence of stable, intermediate stages in evolution. Simon offers an abstract model of any process that succeeds in meeting these requirements. This model necessarily involves construction through a decomposable hierarchy, and thus suggests that any complex, natural, i.e., evolved, system is constituted by a decomposable hierarchy. I argue that Stuart Kauffman's recent models of genetic regulatory networks succeed in specifying processes that could meet Simon's requirements for evolvability without requiring construction through a decomposable hierarchy. Since Kauffman's models are at least as plausible as Simon's model, Simon's argument that complex natural systems must constitute decomposable, mereological or functional hierarchies does not succeed.
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  • 52
    ISSN: 1573-0646
    Schlagwort(e): Antagonist G ([Arg6, D-Trp7,9,,MePhe 8 ]-Substance P {6-11}) ; analytical characterization ; parenteral formulation ; stability ; oxidative degradation products
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract The aim of this study was to develop a stable parenteral dosage form for the investigational cytotoxic drug [Arg6, D-Trp7,9, MePhe8]-Substance P {6-11} (Substance P Antagonist G; Antagonist G). Antagonist G bulk drug was structurally and analytically characterized. The drug exhibits excellent aqueous solubility, although relatively poor aqueous stability characteristics. Lyophilization was, therefore, selected as the manufacturing process. Differential scanning calorimetry studies were conducted to determine the freeze-drying cycle parameters which resulted in a stable, lyophilized formulation of Antagonist G. The prototype, containing 50 mg Antagonist G per vial, was found to be the optimal formulation in terms of solubility, length of the freeze-drying cycle, stability, and dosage requirements in the planned phase I clinical trials. Quality control of the freeze-dried formulation showed that the manufacturing process does not change the integrity of Antagonist G. Shelf life studies demonstrated that the formulation is stable for at least 3 years, when stored at 2–8°C in a dark environment. Oxidative degradation products of Antagonist G were isolated and structurally characterized by mass spectrometry, nuclear magnetic resonance spectroscopy, and infrared spectroscopy.
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  • 53
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 19 (1998), S. 163-168 
    ISSN: 1573-2754
    Schlagwort(e): nonlinear equation ; stability ; Newton's method ; auto-adjustable damping method ; the vector of damping factors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract The general approach for solving the nonlinear equations is linearizing the equations and forming various iterative procedures, then executing the numerical simulation. For the strongly nonlinear problems, the solution obtained in the iterative process is always difficult, even divergent due to the numerical instability. It can not fulfill the engineering requirements. Newton's method and its variants can not settle this problem. As a result, the application of numerical simulation for the strongly nonlinear problems is limited. An auto-adjustable damping method has been presented in this paper. This is a further improvement of Newton's method with damping factor. A set of vector of damping factor is introduced. This set of vector can be adjusted continuously during the iterative process in accordance with the judgement and adjustment. An effective convergence coefficient and quichening coefficient are employed to relax the restricted requirements for the initial values and to shorten the iterative process. Then, the numerical stability will be ensured for the solution of complicated strongly nonlinear equations. Using this method, some complicated strongly nonlinear heat transfer problems in airplanes and aeroengines have been numerically simulated successfully. It can be used for the numerical simulation of strongly nonlinear problems in engineering such as nonlinear hydrodynamics and aerodynamics, heat transfer and structural dynamic response etc.
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  • 54
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 19 (1998), S. 861-867 
    ISSN: 1573-2754
    Schlagwort(e): rotating fluids ; motion of body ; small disturbances ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract In this paper, the disturbances to a uniformly rotating ideal fluid with a sphere moving steadily along the axis of rotation are analysed by using linearization theory, the equations of disturbance, pressure and disturbance stream function governing the stability of motion are derived based on the assumption that the flow is rotational symmetric. The equation of disturbance stream function is analysed with the method of normal modes, and the constraints on wave number and wave velocity of the nontrivial neutral disturbances are established and the exact expression of the neutral disturbances are obtained. The conclusion is drawn that three are three kinds of possible forms of neutral disturbances.
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  • 55
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 20 (1999), S. 912-916 
    ISSN: 1573-2754
    Schlagwort(e): delay ; neural network ; stability ; TN911.23 ; O332
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract In this paper, by using Liapunov functional, some sufficient conditions are obtained for the stability of the equilibrium of a neural network model with delay of the type $$u'_i \left( t \right) = - b_i u_i \left( t \right) + \sum\limits_{j = 1}^n {T_{ij} f_j } \left( {\mu _j u_j \left( {t - \tau _j } \right)} \right) + c_i ,\tau _j \geqslant 0,i = 1,2 \cdots ,n.$$
    Materialart: Digitale Medien
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  • 56
    Digitale Medien
    Digitale Medien
    Springer
    Studia geophysica et geodaetica 42 (1998), S. 320-327 
    ISSN: 1573-1626
    Schlagwort(e): MHD ; stability ; bifurcations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie , Physik
    Notizen: Abstract A series of numerical studies on the behaviour of magnetic fields and motions in a spherical body of an electrically conducting incompressible fluid have been carried out. The magnetic field was assumed to be maintained by a given electromotive force inside the body and to continue as a potential field in outer space. In view of the motion an external forcing was taken into account, and boundary conditions were considered which correspond to a stress-free surface. The stability of several steady states has been studied as well as the evolutions starting from unstable states. In this paper a configuration with a poloidal magnetic field and a differential rotation, both symmetric about the same axis, is considered. This configuration is stable only for sufficiently small Hartmann numbers but evolves, if disturbed, in the case of larger Hartmann numbers toward a non-axisymmetric state. In this case the well-known symmetrization effect of differential rotation in magnetic fields is destroyed.
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  • 57
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 19 (1998), S. 457-462 
    ISSN: 1573-2754
    Schlagwort(e): neural networks ; equilibrium ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract In this paper, some sufficient conditions are obtained for the global asymptotic stability of the equilibrium of neural networks with interneuronal transmission delays of the type $$x'_i (t) = - b_i x_i (t) + \sum\limits_{j = 1}^n {\omega _{\ddot y} f_j (x_j (t - \tau _j )) + p_i (t 〉 0;i = 1,2, \cdots ,n)} $$
    Materialart: Digitale Medien
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  • 58
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 20 (1999), S. 1384-1388 
    ISSN: 1573-2754
    Schlagwort(e): nonlinear dynamic system ; bifurcation ; stability ; TB123 ; O322
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract A computation algorithm based on the Poincaré Mapping in combination with Pseudo-Arc Length Continuation Method is presented for calculating the unstable response with saddle-node bifurcation, and the singularity, which occurs using the general continuation method combined with Poincaré Mapping to follow the path, is also proved. A normalization equation can be introduced to avoid the singularity in the process of iteration, and a new iteration algorithm will be presented too. There will be two directions in which the path can be continued at each point, but only one can be used. The method of determining the direction will be presented in the paper. It can be concluded that is method is effective in analysis of nonlinear dynamic system with saddle-node bifurcations.
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  • 59
    Digitale Medien
    Digitale Medien
    Springer
    Applied mathematics and mechanics 20 (1999), S. 233-240 
    ISSN: 1573-2754
    Schlagwort(e): viscoelasticity ; cylindrical shell ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract In this paper, the dynamic stability of a viscoelastic circular cylindrical shell subject to an axial compressive force and a uniformly distributed radial compressive load is discussed. By using the Laplace transformation, stability conditions of viscoelastic shell under constant loads are yielded. By using synthetically the classical dynamic methods, the various dynamical properties for the dynamical system defined by the viscoelastic shell and the effect of parameters on the stability of structure are obtained.
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  • 60
    Digitale Medien
    Digitale Medien
    Springer
    Discrete event dynamic systems 8 (1998), S. 137-173 
    ISSN: 1573-7594
    Schlagwort(e): hybrid systems ; switched systems ; timed Petri nets ; stability ; supervisory control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper, timed Petri nets are used to model and control hybrid systems. Petri nets are used instead of finite automata primarily because of the advantages they offer in dealing with concurrency and complexity issues. A brief overview of existing results on hybrid systems that are based on Petri nets is first presented. A class of timed Petri nets named programmable timed Petri nets (PTPN) is then used to model hybrid systems. Using the PTPN, the stability and supervisory control of hybrid systems are addressed and efficient algorithms are introduced. In particular, we present sufficient conditions for the uniform ultimate boundness of hybrid systems composed of multiple linear time invariant plants which are switched between using a logical rule described by a Petri net. This paper also examines the supervisory control of a hybrid system in which the continuous state is transfered to a region of the state space in a way that respects safety specifications on the plant's discrete and continuous dynamics.
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  • 61
    Digitale Medien
    Digitale Medien
    Springer
    Journal of scientific computing 13 (1998), S. 173-183 
    ISSN: 1573-7691
    Schlagwort(e): Modified conjugate gradient method ; conjugate gradient method ; Krylov space ; convergence rate ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract In this note, we examine a modified conjugate gradient procedure for solving $$A\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{x} = \underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ in which the approximation space is based upon the Krylov space ( $$A\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{x} = \underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ ) associated with $$\sqrt A$$ and $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ . We show that, given initial vectors $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ and $$\sqrt A \underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ (possibly computed at some expense), the best fit solution in $$K^k \sqrt A ,\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{b}$$ can be computed using a finite-term recurrence requiring only one multiplication by A per iteration. The initial convergence rate appears, as expected, to be twice as fast as that of the standard conjugate gradient method, but stability problems cause the convergence to be degraded.
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  • 62
    Digitale Medien
    Digitale Medien
    Springer
    Neural processing letters 10 (1999), S. 267-271 
    ISSN: 1573-773X
    Schlagwort(e): recurrent neural networks ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract In this paper, we point out that the conditions given in [1] are sufficient but unnecessary for the global asymptotically stable equilibrium of a class of delay differential equations. Instead, we prove that under weaker conditions, it is still global asymptotically stable.
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  • 63
    ISSN: 1573-773X
    Schlagwort(e): constrained learning ; factorization ; feedforward networks ; IIR filters ; polynomials ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract Adaptive artificial neural network techniques are introduced and applied to the factorization of 2-D second order polynomials. The proposed neural network is trained using a constrained learning algorithm that achieves minimization of the usual mean square error criterion along with simultaneous satisfaction of multiple equality and inequality constraints between the polynomial coefficients. Using this method, we are able to obtain good approximate solutions for non-factorable polynomials. By incorporating stability constraints into the formalism, our method can be successfully used for the realization of stable 2-D second order IIR filters in cascade form.
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  • 64
    Digitale Medien
    Digitale Medien
    Springer
    Discrete event dynamic systems 9 (1999), S. 45-64 
    ISSN: 1573-7594
    Schlagwort(e): hybrid dynamic systems ; event feedback ; real-time scheduling ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Based on some practical engineering problems arising from process control and space-structure control, this paper studies a class of hybrid dynamic systems in which N plants are controlled by a central controller in sharing time manner, where the plants are described by differential equations and the controller works according to the mechanism of discrete events. An event feedback strategy is suggested to be a scheduling policy such that one and only one plant among N plants is chosen to be controlled at any time. Some conditions of asymptotical and exponential stability are then given and an exponential upper bound of states norm is also estimated for the event feedback scheduling strategy. An algorithm based on event feedback strategy is presented to determine the control laws of the plants to meet the given performance. An example follows to illustrate the application and effect of the results.
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  • 65
    Digitale Medien
    Digitale Medien
    Springer
    Lithuanian mathematical journal 39 (1999), S. 20-32 
    ISSN: 1573-8825
    Schlagwort(e): Schrödinger equation ; explicit finite-difference schemes ; stability ; energy conservation ; convergence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We consider three-level explicit schemes for solving the nonlinear variable coefficient Schrödinger-type equation. Using spectral and energy methods we establish the stability and convergence of these schemes. The existence of discrete conservation laws is investigated. General results are applied for the DuFort-Frankel and leap-frog diffenrence schemes.
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  • 66
    Digitale Medien
    Digitale Medien
    Springer
    International tax and public finance 6 (1999), S. 621-639 
    ISSN: 1573-6970
    Schlagwort(e): expectations ; bubbles ; uniqueness ; stability ; state variables ; multiplicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Wirtschaftswissenschaften
    Notizen: Abstract This paper concerns the minimal-state-variable (MSV) criterion for selection among solutions in rational expectationsmodels that feature a multiplicity of paths that satisfy all of the model's conditions. It compares the MSVcriterion with others, including the widely used saddle-path (dynamic stability) criterion. It is emphasized that theMSV criterion can be viewed as a scientifically useful classification scheme that delineates the unique solutionthat is free of bubble components. In the process of demonstrating uniqueness for a broad class of linear models,the paper exposits a convenient computational procedure. Applications to current issues are outlined.
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  • 67
    Digitale Medien
    Digitale Medien
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    Mechanics of composite materials 35 (1999), S. 495-506 
    ISSN: 1573-8922
    Schlagwort(e): layered structure ; shells ; frames ; stringers ; nonlinearity ; stability ; pulsed loading ; numerical methods
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract Nonlinear three-dimensional problems of dynamic deformation, buckling, and posteritical behavior of composite shell structures under pulsed loads are analyzed. The structure is assumed to be made of rigidly joined plates and shells of revolution along the lines coinciding with the coordinate directions of the joined elements. Individual structural elements can be made of both composite and conventional isotropic materials. The kinematic model of deformation of the structural elements is based on Timoshenko-type hypotheses. This approach is oriented to the calculation of nonstationary deformation processes in composite structures under small deformations but large displacements and rotation angles, and is implemented in the context of a simplified version of the geometrically nonlinear theory of shells. The physical relations in the composite structural elements are based on the theory of effective moduli for individual layers or for the package as a whole, whereas in the metallic elements this is done in the framework of the theory of plastic flow. The equations of motion of a composite shell structure are derived based on the principle of virtual displacements with some additional conditions allowing for the joint operation of structural elements. To solve the initial boundary-value problem formulated, an efficient numerical method is developed based on the finite-difference discretization of variational equations of motion in space variables and an explicit second-order time-integration scheme. The permissible time-integration step is determined using Neumann's spectral criterion. The above method is especially efficient in calculating thin-walled shells, as well as in the case of local loads acting on the structural element, when the discretization grid has to be condensed in the zones of rapidly changing solutions in space variables. The results of analyzing the nonstationary deformation processes and critical loads are presented for composite and isotropic cylindrical shells reinforced with a set of discrete ribs in the case of pulsed axial compression and external pressure.
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  • 68
    Digitale Medien
    Digitale Medien
    Springer
    Journal of dynamical and control systems 4 (1998), S. 457-519 
    ISSN: 1573-8698
    Schlagwort(e): Boundary control ; nonlinear distributed parameter system ; center manifold theorem ; stability ; local attractors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper we consider a boundary control problem for a forced Burgers' equation in a Hilbert state space consisting of square integrable functions on a finite interval. Our first main result consists in proving the global in time existence of solutions of the closed loop boundary control system for arbitrary L 2 initial data and quite general forcing terms (disturbances). For the unforced problem, our main interest is in stability of equilibria, while for the forced problem we are interested in steady state behavior of solutions. We note that the uncontrolled (open loop), unforced problem is not asymptotically stable on L 2. However, for positive gains we show that the unforced closed loop system is globally Lyapunov stable and locally exponentially stable. In addition, for nonzero stationary forcing, we show that there is a local absorbing ball and that the corresponding nonlinear semigroup is compact for all t 〉 0. Using this fact, we are able to deduce several consequences regarding the existence and properties of local attractors. Our method of proof is based on a systematic investigation of the smoothing properties of the controlled dynamics. In particular we establish various regularity results for the dynamics of the closed loop system.
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  • 69
    Digitale Medien
    Digitale Medien
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    Dynamics and control 8 (1998), S. 83-106 
    ISSN: 1573-8450
    Schlagwort(e): fuzzy modeling ; robust control ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Robust control designs for a discrete Takagi and Sugeno (T-S) fuzzy model are proposed. The T-S fuzzy model contains (possibly fast) time-varying uncertainty. First, a switching-type robust control is shown to stabilize the T-S fuzzy model asymptotically. Second, a saturation-type robust control is shown to render the T-S model practically stable. In both designs, only the bound of uncertainty is needed. The effectiveness of proposed designs is analyzed rigorously and illustrated by simulations.
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  • 70
    Digitale Medien
    Digitale Medien
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    Mathematical notes 63 (1998), S. 396-400 
    ISSN: 1573-8876
    Schlagwort(e): ordinary differential equations ; fast and slow time ; periodic solutions ; existence ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We consider a system of ordinary first-order differential equations. The right-hand sides of the system are proportional to a small parameter and depend almost periodically on fast time and periodically on slow time. With this system, we associate the system averaged over fast time. We assume that the averaged system has a structurally unstable periodic solution. We prove a theorem on the existence and stability of almost periodic solutions of the original system.
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  • 71
    Digitale Medien
    Digitale Medien
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    Journal of dynamical and control systems 5 (1999), S. 501-507 
    ISSN: 1573-8698
    Schlagwort(e): Singular perturbation ; invariant manifold ; overflowing manifold ; stability ; characteristic numbers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A singularly perturbed system with a small parameter ε at the velocity of the slow variable y and with the fast variable x is considered. The main hypothesis is that for all y from some bounded domain D, the fast subsystem has a stable invariant or overflowing manifold M 0(y) and that the motions in this system going in the directions transversal to M 0(y) are more fast than the mutual approaching of trajectories on M 0(y) (a precise statement is given in terms of appropriate Lyapunov-type characteristic numbers). It is proved that for a sufficiently small ε, the whole system has an invariant manifold close to $$\bigcup\limits_{y \in D} {M_0 (y) \times \{ y\}}$$ the degree of its smoothness is specifed.
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  • 72
    ISSN: 1573-904X
    Schlagwort(e): polymer implant ; brain cancer ; carmustine ; polyanhydride ; stability ; controlled release
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
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  • 73
    ISSN: 1573-904X
    Schlagwort(e): nanoparticles ; poly(lactic acid) ; poly(lactic acid-co-ethylene oxide) ; freeze-drying ; stability ; flow cytometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. To investigate the feasibility of producing freeze-dried poly-(ethylene oxide) (PEO)-surface modified nanoparticles and to study their ability to avoid the mononuclear phagocytic system (MPS), as a function of the PEO chain length and surface density. Methods. The nanoparticles were produced by the salting-out method using blends of poly(D,L-lactic acid) (PLA) and poly(D,L-lactic acid-co-ethylene oxide) (PLA-PEO) copolymers. The nanoparticles were purified by cross-flow filtration and freeze-dried as such or with variable amounts of trehalose as a lyoprotectant. The redispersibility of the particles was determined immediately after freeze-drying and after 12 months of storage at −25° C. The uptake of the nanoparticles by human monocytes was studied in vitro by flow cytometry. Results. PLA-PEO nanoparticles could be produced from all the polymeric blends used. Particle aggregation after freeze-drying was shown to be directly related to the presence of PEO. Whereas this problem could be circumvented by use of trehalose, subsequent aggregation was shown to occur during storage. These phenomena were possibly related to the specific thermal behaviours of PEO and trehalose. In cell studies, a clear relationship between the PEO content and the decrease of uptake was demonstrated. Conclusions. The rational design of freeze-dried PEO-surface modified nanoparticles with potential MPS avoidance ability is feasible by using the polymer blends approach combined with appropriate lyoprotection and optimal storage conditions.
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  • 74
    Digitale Medien
    Digitale Medien
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    Pharmaceutical research 15 (1998), S. 1702-1707 
    ISSN: 1573-904X
    Schlagwort(e): stability ; isothermal ; nonisothermal ; thymopentin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. The degradation kinetics of thymopentin (RKDVY) and its analogs (RKDVW and RPDVY) in aqueous solution was studied by isothermal and nonisothermal methods. Methods. The isothermal decomposition of thymopentin and its analogs was investigated as a function of pH (2−10), temperature (37, 57, and 80°C) and ionic strength (μ = 0.02 to 1). Nonisothermal decomposition studies were performed using a linear temperature programmer. The temperature increasing rate was set to 0.25°C per hour and the temperature interval varied from 40 to 88°C. Results. The decomposition of thymopentin and its analogs followed first order kinetics. The dependence of the rate constant on temperature followed a linear Arrhenius plot. This indicated that the degradation mechanism of thymopentin and its analogs might be the same within the temperature range studied. The energies of activation were found to be in close agreement for the isothermal and nonisothermal studies, suggesting that the nonisothermal studies may save considerable amount of time in the early stages of drug development. The logK-pH profile of thymopentin suggests that maximum stability is achieved in the pH range of 6−8. Conclusions. These results indicate that the nonisothermal methodology provides an attractive alternative to isothermal methods, as it requires a much lower amount of both material and time, to determine the peptide stability and to estimate the shelf-life for peptide pharmaceutical preparations.
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  • 75
    ISSN: 1573-904X
    Schlagwort(e): calcitonin ; polyethylene glycol ; PEGylation ; peptide ; tryptic digestion ; stability ; HPLC
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. To separate and characterize the different positional isomers of mono-PEGylated salmon calcitonins (mono-PEG-sCTs) and to evaluate the effects of the PEGylation site on the stability of different mono-PEG-sCTs in rat kidney homogenate. Methods. Mono-PEG-sCTs were prepared using succinimidyl carbonate monomethoxy polyethylene glycol (5,000 Da) and separated by gel-filtration HPLC followed by reversed-phase HPLC. To characterize PEGylated sCTs, matrix-assisted laser desorption ionization time of flight mass spectrometry (M ALDI-TOF MS) and reversed-phase HPLC of the trypsin digested samples were performed. Mono-PEG-sCTs and sCT in rat kidney homogenates were measured by column-switching reversed-phase HPLC with on-line detection of the radioiodinated samples using a flow-through radioisotope detector. Results. Three different mono-PEGylated sCTs were separated by reversed-phase gradient HPLC. From the MALDI-TOF MS analysis, the average molecular weight of mono-PEG-sCTs was confirmed as around 8650 Da. The presence of PEG moiety in the mono-PEG-sCTs was also manifested by the fact that the distance between two adjacent mass spectum lines was 44 Da which corresponds to PEG monomer unit. Tryptic digestion analysis demonstrated that these mono-PEG-sCTs are 3 positional isomers of N-terminus, Lys18- and Lys11-residue modified mono-PEGylated sCTs. The degradation half-life of these 3 positional isomers in rat kidney homogenates significantly increased in order of the N-terminus (125.5 min), Lys11- (157.3 min), and Lysl8-residue modified mono-PEGylated sCT (281.5 min) over the native sCT (4.8 min). Conclusions. Three positional isomers of mono-PEGylated sCTs were purified and characterized. Of these, the resistance to proteolytic degradation was highest for the Lysl8-residue modified mono-PEG-sCT. These studies demonstrate that the in vivo stability of PEGylated sCTs is highly dependent on the site of PEG molecule attachment.
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  • 76
    ISSN: 1573-5060
    Schlagwort(e): Triticum turgidum ; farmers' varieties ; genetic diversity ; composite ; stability ; durum wheat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract The Ethiopian peasant farms are characterized by highly varied micro-environments differing in characteristics such as topography, soil type, water, temperature and fertility. The bulk of the durum wheat planting material currently in use on these farms is largely represented by traditional farmers' varieties/landraces. These traditional farmers' varieties/landraces generally, are stable but low yielding, and often fail to adequately meet the level of productivity essential for production beyond subsistence level, unless they are enhanced to improve their competitiveness with modern varieties in respect to yield. Improving the productivity of landraces, while maintaining an appreciable level of genetic diversity is crucial to yield stability. This could be achieved by developing composites that are formed by bulking together three or more potentially high yielding spikes (agrotypes) that vary for various morphologic and agronomic characteristics, but due to their similarity in plant height, maturity, glume color and seed color give the composite a uniform field appearance like a modern variety.
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  • 77
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    Environmental biology of fishes 53 (1998), S. 365-371 
    ISSN: 1573-5133
    Schlagwort(e): Carassius auratus ; Metynnis hypsauchen ; Pterophyllum scalare ; goldfish ; angelfish ; silver dollar ; swimming ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Goldfish, Carassius auratus, silver dollar, Metynnis hypsauchen, and angelfish, Pterophyllum scalare were induced to swim through narrow vertical and horizontal tubes ranging in length from 0 to 20 cm (approximately 0 to 3 times total fish length, FL). The ability to stabilize the body while negotiating these confined spaces was quantified as (1) the minimum width of vertical (wv) and horizontal (wh) tubes traversed, where width is the smaller cross-sectional dimension of the tube, (2) the ratio wv/wh, and (3) transit speed through the tubes. Tube width was expressed as relative width, obtained by dividing tube width by fish length. Minimum relative widths traversed increased from 0.15 to 0.19 in the order silver dollar 〉 angelfish 〉 goldfish for vertical tubes and from 0.17 to 0.18 in the order goldfish=silver dollar 〉 angelfish for horizontal tubes. wv/wh increased from 0.91 to 1.10 in the order silver dollar=angelfish 〉 goldfish. Minimum tube widths generally increased with tube length for vertical tubes. Although significant differences in relative minimum widths among species were found, these were small. In contrast, for horizontal tubes, there was no significant effect of tube length on minimum tube width for any species. Large differences were found in transit speed. Transit speed generally decreased as the tube length increased. The slope of the relationship between transit speed and tube length varied among species generally increasing from − 0.41 to − 1.16 for horizontal tubes in the order goldfish 〉 silver dollar 〉 angelfish and from − 0.42 to − 1.07 in the order silver dollar 〉 goldfish 〉 angelfish for vertical tubes. As a result, goldfish usually took longest to traverse tubes of zero length but the shortest time to traverse the longest tubes. In contrast, angelfish traversed short tubes in the least time and long tubes in the greatest time. Deeper bodied angelfish swam slowly and traversed tubes with difficulty because they required experience during each trial to replace median and paired fin with body and caudal fin swimming. According to our data, goldfish were best able to swim in confined spaces.
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  • 78
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    Flow, turbulence and combustion 62 (1999), S. 137-162 
    ISSN: 1573-1987
    Schlagwort(e): laminar wall jet ; heat transfer ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract The hydrodynamic stability of a low speed, plane, non-isothermal laminar wall jet at a constant temperature boundary condition was investigated theoretically and experimentally. The mean velocity and temperature profiles used in the stability analysis were obtained by implementing the Illingworth–Stewartson transformation that allows one to extend the classical Glauert solution to a thermally non-uniform flow. The stability calculations showed that the two unstable eigenmodes coexisting at moderate Reynolds numbers are significantly affected by the heat transfer. Heating is destabilizing the flow while cooling is stabilizing it. However, the large-scale instabilities associated with the inflection point of the velocity profile still amplify in spite of the high level of the stabilizing temperature difference. The calculated stability characteristics of the wall jet with heat transfer were compared with experimental data. The comparison showed excellent agreement for small amplitudes of the imposed perturbations. The agreement is less good for the phase velocities of the sub-harmonic wave and this is attributed to experimental difficulties and to nonlinear effects.
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  • 79
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    Earth, moon and planets 87 (1999), S. 103-115 
    ISSN: 1573-0794
    Schlagwort(e): Accretion ; exoplanetary system ; extrasolar planets ; numerical integration ; orbital migration ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract A number of extrasolar planets have been detected in close orbits around nearby stars. It is probable that these planets did not form in these orbits but migrated from their formation locations beyond the ice line. Orbital migration mechanisms involving angular momentum transfer through tidal interactions between the planets and circumstellar gas-dust disks or by gravitational interaction with a residual planetesimal disk together with several means of halting inward migration have been identified. These offer plausible schemes to explain the orbits of observed extrasolar giant planets and giant planets within the Solar System. Recent advances in numerical integration methods and in the power of computer workstations have allowed these techniques to be applied to modelling directly the mechanisms and consequences of orbital migration in the Solar System. There is now potential for these techniques also to be applied to modelling the consequences of the orbital migration of planets in the observed exoplanetary systems. In particular the detailed investigation of the stability of terrestrial planets in the habitable zone of these systems and the formation of terrestrial planets after the dissipation of the gas disk is now possible. The stability of terrestrial planets in the habitable zone of selected exoplanetary systems has been established and the possibility of the accretion of terrestrial planets in these systems is being investigated by the author in collaboration with Barrie W. Jones (Open University), and with John Chambers (NASA-Ames) and Mark Bailey of Armagh Observatory, using numerical integration. The direct simulation of orbital migration by planetesimal scattering must probably await faster hardware and/or more efficient algorithms.
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  • 80
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    Multidimensional systems and signal processing 10 (1999), S. 7-20 
    ISSN: 1573-0824
    Schlagwort(e): multivariate polynomials ; stability ; robust stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper presents a detailed analysis of some classes of stable multivariate polynomials. The main aim of the analysis is to give conditions under which polynomials preserve stability when they are subjected to small coefficient variations. The maximal class of such polynomials is introduced. Some basic properties of polynomials from this class are obtained.
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  • 81
    ISSN: 1435-1536
    Schlagwort(e): Key words Heterophase polymerization ; emulsion ; polymer particle ; stability ; styrene conversion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract  Heterophase polymerization of styrene in the presence of di-p-tolyl-o-carbalkoxyphenylcarbinol (DTC) soluble in monomer and insoluble in water, as stabilizer, was investigated. The factors affecting polymer particle diameter, their size distribution and stability were investigated. It was suggested that polymer particles are formed from monomer droplets. The polystyrene suspension with narrow particle size distribution synthesized in the presence of DTC, was used for immunochemical research.
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  • 82
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    Empirical economics 23 (1998), S. 387-400 
    ISSN: 1435-8921
    Schlagwort(e): Money demand ; cointegration ; stability ; regime shift ; E41 ; C22
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Wirtschaftswissenschaften
    Notizen: Abstract Using several tests for structural stability in regressions with I(1) variables and for the existence of cointegration in models with regime shifts, the empirical evidence on the existence of a structural break in the Spanish long-run demand for broad money (ALP2) is analysed. The results indicate that shifts affecting the demand for ALP2 in recent years have substantially altered its long-run properties. As to the cause of this structural break, emphasis is placed on the role played by the increasing openness of the Spanish financial system to international markets as obstacles to free capital movements have progressively disappeared.
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  • 83
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    International journal of thermophysics 19 (1998), S. 461-470 
    ISSN: 1572-9567
    Schlagwort(e): small-angle neutron scattering ; stability ; vesicles
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Small-angle neutron scattering (SANS) was used to investigate the structure of mixed colloids of egg yolk phosphatidylcholine (EYPC) with the bile salt, cholylglycine (CG), in D2O as a function of pressure (P) and temperature (T). At atmospheric pressure, the system forms an isotropic phase of mixed, single-bilayer vesicles (SLVs). Increasing the external hydrostatic pressure brought about significant changes in particle morphology. At T=25°C, application of a pressure of 3.5 MPa resulted in collapse of the SLVs. A further increase in P, up to 51.8 MPa, resulted in a transition from a phase of ordered (stacked), collapsed vesicles to one of stacked, ribbon-like particles. A similar collapse of the vesicles was observed at a higher temperature (T=37°C) with increasing P, but at this temperature, no ribbon phase was found at the highest pressure explored.
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  • 84
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    International journal of infrared and millimeter waves 19 (1998), S. 1721-1734 
    ISSN: 1572-9559
    Schlagwort(e): optical phase-locked loop ; stability ; phase jitter ; four-wave mixing ; semiconductor laser amplifier
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract In this paper, the properties of the optical phase-locked loop(PLL) based on the four-wave mixing in the semiconductor laser amplifiers (SLAs) are discussed. The components that achieve the function of detecting the bit phase of the input optical signal are concerned and discussed in detail together as a function module named as the optical bit phase detector referred to the general electronic PLL. Therefore, most of the properties of the optical PLL can be analyzed by applying the general phase-locked theory. Here the stability of the optical PLL is discussed. It's shown that the variance of input signal power in the practical application will cause optical PLL system unstable because of its long loop delay. The influence on the output phase jitter of the optical PLL is also investigated.
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  • 85
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    Euphytica 102 (1998), S. 151-161 
    ISSN: 1573-5060
    Schlagwort(e): Oryza sativa ; head rice ; seeding date ; rice ; rough rice yield ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract The rice (Oryza sativa L.) crop in Arkansas is seeded from late March through early June each year. Farmers need new rice cultivars that not only produce both high rough rice yields and high head rice across this range of seeding dates but do so consistently. Thus, a seeding date study was conducted during 1994 and 1995 at Stuttgart, Arkansas, to study seeding date effects on rough rice yield and head rice and selection for stability. Fourteen rice cultivars were seeded at five dates ranging from late March through mid-June. Kang's yield-stability statistic was used to select cultivars for both high rough rice yields and high head rice as well as stability for both traits. Plant stands from March seedings of each year were significantly lower than for the later seeding dates. Maturity (days to 50 percent heading) was extended at the early seeding dates. Some rice cultivars, such as ‘LaGrue’, had lower and more variable head rice when seeded early. In the June seeding dates each year, ‘Kaybonnet’ produced rough rice yields that were more consistent with yields when planted at the earlier planting dates. ‘Bengal’, ‘Cypress’, ‘Kaybonnet’, and ‘Newbonnet’ were cultivars selected by Kang's stability statistic, which was targeted to select cultivars with stable, high rough rice yields and stable, high head rice. The validity of using Kang's yield-stability statistic for cultivar selection is also evident empirically by the adaptation and wide use of these four cultivars by southern U.S. rice producers. These results indicate that seeding date studies and stability analyses would be useful tools for rice breeders to identify cultivars that will be readily adapted and grown by rice producers.
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  • 86
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    Euphytica 100 (1998), S. 15-18 
    ISSN: 1573-5060
    Schlagwort(e): biparental mating ; stability ; Triticum durum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract Three populations of an intervarietal durum wheat cross IWP5308/PDW208, F5, F5BIP1 (population derived after intermating in F2) and F5BIP2 (population derived after intermating in BIPF1), were evaluated under three different agronomic environments for mean performance and stability of genotypes for grain yield, yield components and protein content. Though the biparental progenies indicated a higher mean performance, they did not differ significantly from progenies of the pedigree method for almost all characters. The biparental progenies, however, produced a higher number of stable genotypes for grain yield per plant, grains per ear and protein content. The F5 population had a higher number of stable genotypes for 1000 grain weight and number of tillers per plant. The BIP progenies also had a higher number of genotypes with above average mean performance, and many were significantly higher than the checks WH896 and WH542, compared with F5 progenies. Hence, in spite of high G x E interactions, the use of cycles of biparental mating and selection of top yielding lines on the basis of yield components can enable selection of stable genotypes with high protein content. Number of tillers per plant and 1000 grain weight were the yield component characters which made maximum contribution to phenotypic stability of the genotypes.
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  • 87
    ISSN: 1573-5060
    Schlagwort(e): adaptation ; correlations ; genotype-environment interaction ; landraces ; performance ; stability ; tetraploid wheat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract Plant breeding has always been concerned with genotype-environment interaction. Normally high and stable performance are desirable attributes of cultivars. However, this is practically difficult to achieve where environmental variations are high and unpredictable and significant genotype-environment interactions occur. Stability of performance of 13 landraces evaluated at 4 different locations for 3 years in the highlands of Ethiopia was investigated. The testing locations have different climatic and edaphic conditions providing the conditions necessary for the assessment of stability. Stability parameters like b, s2d, s2, r2 and cv which are in common use were employed. Grain yield and 1000-kernel weight were the agronomic traits considered for the stability analysis. There were differences in the ranks of genotypes across the locations. Significant main environmental as well as interaction effects were observed showing the importance of genotype-environment interaction in both traits. Many of the landraces evaluated are rated as stable for these traits within the environmental conditions prevailing in these highland locations. Genotypes with specific adaptation to poor and favourable conditions were also identified. Certain genotypes showed similar manners of adaptation and stability for both of the traits. Grain yield showed low correlations with the stability parameters showing the possibility of attaining high yield and stability. Correlations between the stability parameters were mainly positive and significant for grain yield. Only a few of these correlations were found to be significant for kernel weight. The good adaptability of landraces should be exploited in the improvement of their yield potential.
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  • 88
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    Hydrobiologia 385 (1998), S. 201-211 
    ISSN: 1573-5117
    Schlagwort(e): hypoxia ; anoxic hypolimnion ; volcanic crater lake ; stratification ; productivity ; heat budget ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract This paper quantifies the temporal pattern of thermal stratification and deoxygenation in Lake Nkuruba, a small (3 ha), deep (maximum depth = 38 m) crater lake in western Uganda. Dissolved oxygen penetrated to an average depth of 9 m and a maximum depth of 15 m below which the lake was permanently anoxic over the 2 years of study. Although surface oxygen levels were correlated with both surface water temperature and rainfall, seasonal cycles of dissolved oxygen were not well-defined and may have been obscured by the high frequency of short-term fluctuations and by inter-annual variations caused by shifts in rainfall. Surface water temperature averaged 23.3±0.7 °C (S.D.) and varied directly with air temperature. Both diurnal changes and top-bottom temperature differentials were small averaging 1.7±0.7 °C and 1.6±0.8 °C, respectively. Thermal stability ranged from 101.3 to 499.9 g-cm cm-2 and was positively related to surface water temperature suggesting that this small protected lake responds rapidly to short-term meteorological changes. Because contribution to the annual heat exchange cycle was confined to upper waters, the lake's annual heat budget was low, 1,073.8 cal cm-2 yr-1. However, net primary productivity was relatively high averaging 1.3 g C m-2d-1. The region where Lake Nkuruba is situated experienced a very strong earthquake (6.2 on the Richter scale) on 4 February, 1994. Subsequently, water levels dropped markedly in the lake, falling 3.14 m over a 5-month period.
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  • 89
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    Hydrobiologia 385 (1998), S. 201-211 
    ISSN: 1573-5117
    Schlagwort(e): hypoxia ; anoxic hypolimnion ; volcanic crater lake ; stratification ; productivity ; heat budget ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract This paper quantifies the temporal pattern of thermal stratification and deoxygenation in Lake Nkuruba, a small (3 ha), deep (maximum depth = 38 m) crater lake in western Uganda. Dissolved oxygen penetrated to an average depth of 9 m and a maximum depth of 15 m below which the lake was permanently anoxic over the 2 years of study. Although surface oxygen levels were correlated with both surface water temperature and rainfall, seasonal cycles of dissolved oxygen were not well-defined and may have been obscured by the high frequency of short-term fluctuations and by inter-annual variations caused by shifts in rainfall. Surface water temperature averaged 23.3±0.7 °C (S.D.) and varied directly with air temperature. Both diurnal changes and top-bottom temperature differentials were small averaging 1.7±0.7 °C and 1.6±0.8 °C, respectively. Thermal stability ranged from 101.3 to 499.9 g-cm cm-2 and was positively related to surface water temperature suggesting that this small protected lake responds rapidly to short-term meteorological changes. Because contribution to the annual heat exchange cycle was confined to upper waters, the lake's annual heat budget was low, 1,073.8 cal cm-2 yr-1. However, net primary productivity was relatively high averaging 1.3 g C m-2d-1. The region where Lake Nkuruba is situated experienced a very strong earthquake (6.2 on the Richter scale) on 4 February, 1994. Subsequently, water levels dropped markedly in the lake, falling 3.14 m over a 5-month period.
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  • 90
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    Hydrobiologia 403 (1999), S. 123-133 
    ISSN: 1573-5117
    Schlagwort(e): disturbance ; stability ; resilience ; Trichoptera ; Ephemeroptera ; Psychomyia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Benthic macroinvertebrate assemblages of Bushkill Creek, Northampton County, PA were studied at the same site during the 1970s (11 dates) and 1990s (8 dates) to evaluate stability and resilience. In the 1970s, a Surber sampler was used, and in the 1990s, a Hess sampler. Assemblages appeared stable over a wide range of environmental stresses with the exception of 1994–1995 when total numbers and total Trichoptera decreased. Taxa richness and EPT indices varied little in 1994–1995 from other sampled years. By July 1996, all metrics (Trichoptera numbers, total numbers, taxa richness, EPT index, Bray-Curtis Index) resembled the 1970s exception for lower wet weight. Bray-Curtis indices and taxa composition were similar in July 1972 and July 1996, suggesting assemblage stability over 25 years. The Trichoptera, Psychomyia (Psychomiidae) and Leucotrichia (Hydroptilidae), decreased during the 1990s and never rebounded to 1970s numbers. During winter 1994, the coldest temperatures and greatest cumulative snowfall occurred in the region. These conditions probably stressed the assemblage with low temperatures, anchor/frazil ice and ice break-up. The assemblage was then exposed to four bankful floods in winter/spring 1994 and five bankful floods in winter/spring 1996. Recovery time following these multiple disturbances was 27 months. Previous recovery times from winter and flood disturbances were considerably shorter (2–5 months). The 1990s recovery time (5–9 times previusly recorded) for this assemblage was apparently extended by multiple physical disturbances, outside the predicted range. The assemblages had not been previously exposed to such severe conditions and, therefore, recovery time was extended. Despite severe weather conditions, the assemblage recovered and exhibited both stability and resilience in its return to an assemblage similar to the 1970s.
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  • 91
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    Journal of optimization theory and applications 97 (1998), S. 707-729 
    ISSN: 1573-2878
    Schlagwort(e): Nonlinear integral equations ; optimal control in L p-spaces ; relaxation ; existence ; stability ; nonconcentration ; optimality conditions ; Pontryagin maximum principle
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Optimal control problems with nonlinear equations usually do not possess optimal solutions, so that their natural (i.e., continuous) extension (relaxation) must be done. The relaxed problem may also serve to derive first-order necessary optimality condition in the form of the Pontryagin maximum principle. This is done here for nonlinear Fredholm integral equations and problems coercive in an L p-space of controls with p〈+∞. Results about a continuous extension of the Uryson operator play a key role.
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  • 92
    ISSN: 1573-3025
    Schlagwort(e): aerosolisation effects ; bioaerosol ; bioaerosol sampling ; effects of recovery agents ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The sampling and assay of bioaerosols are important ina number of industrial and health-care applications. Airborne microorganisms are notoriously difficult toenumerate accurately under such conditions and nosingle procedure is suitable for all applications. Problems are compounded by the differences in assaymethod or sampler type selected, making theinterpretation of results difficult.Understanding the airborne behaviour of microorganismsover a range of environmental conditions is vital ifprocedures are to be defined and recommended for theassessment of bioaerosols. Microorganisms that arerobust over a wide range of conditions are ideal astracer particles. Unfortunately, the large majorityof non-fungal bioaerosols are susceptible to damage. A predictable assessment procedure is required whichwill not affect the viability of the collectedsample. This paper examines how aerosolisation may affect the characteristics of two speciesof microorganism (Pseudomonas fluorescens andMS2 coliphage). It forms part of a larger programmeto develop standards for the assessment of biologicalparticles. The aim of the work was to develop procedures toexamine the effects of aerosolisation onmicroorganisms, with particular reference topre-aerosolisation protocol (spray suspension age) andpost-sampling handling protocol (aerosol age incollection solution). These procedures were then usedto examine the effect of recovery agents, addedto the spray suspension prior to aerosolisation, onthe culturability of E.coli. Aerosolisation reduces the culturability of P. fluorescensand the viability of viability of MS2coliphage. Pre-sampling and post-collection handlingand storage of these aerosolised microorganisms werealso found to have an effect. This and earlierstudies have shown that the culturable fraction ofmicroorganisms can be affected by the same factorsdescribed above. Of five microorganisms tested so farin the main programme, only Penicillium expansumspores were shown to be robust and stable with aconstant culturable fraction. Therefore, recommendinga particular microorganism (apart from P. expansum) as an airborne biological standard foraerosol studies is not advised. It is recommendedthat a microorganism, representative of the envisagedapplication, be characterised it in terms of theaerosolisation parameters, storage time and conditionsin the manner reported in this study. This can beachieved using the experimental equipment described.The addition of 0.1 mM concentrations of the sugarsinositol, trehalose and raffinose to spray suspensionsof Escherichia coli, prior to aerosolisation,made no significant difference to the culturablefraction of the aerosol.
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  • 93
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    Applied mathematics and mechanics 19 (1998), S. 135-146 
    ISSN: 1573-2754
    Schlagwort(e): nonholonomic system ; Lagrange's theorem ; manifold ; stability ; Liapunov's direct method
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract The stability problem for the manifold of equilibrium positions of a class of nonholonomic systems is studied in this paper. Based on Liapunov's direct method and the definition of stability. Lagrange's theorem of holonomic systems is extended to a class of nonholonomic conservative systems and dissipative systems, and a new expression is made to the relation between asymptotic stability for the manifold of equilibrium positions of this class of nonholonomic systems and dissipative forces. Two examples are finally given to illustrate the application of the theorems.
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  • 94
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    Journal of logic, language and information 7 (1998), S. 143-163 
    ISSN: 1572-9583
    Schlagwort(e): Belief revision ; consolidation ; coherence ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen , Informatik
    Notizen: Abstract The notion of epistemic coherence is interpreted as involving not only consistency but also stability. The problem how to consolidate a belief system, i.e., revise it so that it becomes coherent, is studied axiomatically as well as in terms of set-theoretical constructions. Representation theorems are given for subtractive consolidation (where coherence is obtained by deleting beliefs) and additive consolidation (where coherence is obtained by adding beliefs).
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  • 95
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    Applied mathematics and mechanics 20 (1999), S. 564-567 
    ISSN: 1573-2754
    Schlagwort(e): generalized Birkhoff's system ; equilibrium state ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Mathematik , Physik
    Notizen: Abstract In this paper, equilibrium stability of generalized Birkhoff's autonomous system is discussed. First, equilibrium equations of generalized Birkhoff's autonomous system are set up, and then the linear approximate method and direct method of stability in equilibrium state are studied. Some results on equilibrium of generalized Birkhoff's autonomous system are obtained on the basis of Lyapunov's thorem. Last, the application of the results is illustrated with an example.
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  • 96
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    Mathematical methods of operations research 50 (1999), S. 245-270 
    ISSN: 1432-5217
    Schlagwort(e): Key words: Portfolio optimization ; stochastic programming ; stability ; postoptimality ; worst-case analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik , Wirtschaftswissenschaften
    Notizen: Abstract. Solutions of portfolio optimization problems are often influenced by errors or misspecifications due to approximation, estimation and incomplete information. Selected methods for analysis of results obtained by solving stochastic programs are presented and their scope illustrated on generic examples – the Markowitz model, a multiperiod bond portfolio management problem and a general strategic investment problem. The approaches are based on asymptotic and robust statistics, on the moment problem and on results of parametric optimization.
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  • 97
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    Reaction kinetics and catalysis letters 68 (1999), S. 243-247 
    ISSN: 1588-2837
    Schlagwort(e): Methane partial oxidation ; nickel-based catalysts ; stability ; sintering and loss of nickel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The thermal stability and an 80 h life test over nickel-based catalysts for CH4/O2 to syngas reaction were investigated by flow-reactor, XPS, XRD and AAS analysis. The results indicate that the introduction of Li and La not only stabilized the support γ-Al2O3 phase, but also suppressed the sintering and loss of nickel, and in addition, enhanced the ability to suppress the carbon-deposition over NiO/Al2O3 during the high-temperature reaction.
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  • 98
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    Pharmaceutical research 15 (1998), S. 77-81 
    ISSN: 1573-904X
    Schlagwort(e): azetirelin ; thyrotropin-releasing hormone analog ; stability ; nasal absorption ; acylcarnitines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. The long-term stability and nasal absorption characteristics of a basic nasal formulation of azetirelin, a thyrotropin-releasing hormone analog and its absorption enhancement by incorporation of acylcarnitines in the formulation were investigated. Methods. The long-term stability of basic nasal azetirelin formulations at 25° C was predicted by calculation from the Arrhenius plot of the data on 6 months' storage at 40, 50 and 60° C. Nasal azetirelin absorption characteristics were kinetically examined by intranasal administration to rats, determination of plasma azetirelin level by radioimmunoassay, and fitting the data to a two-compartment model including absorption rate. Results. Basic nasal azetirelin formulations of pH 4.0 and pH 5.1 were predicted to be highly stable. Residual azetirelin after 2 years storage at 25° C was greater than 95%. Nasal absorption characteristics of this formulation in the pH 4.0−6.3 range showed pH-dependency, with pH 4.0 showing the highest absolute bioavailability (Bioav) of 17.1%. This nasal Bioav was 21 times greater than that of oral administration (0.8%). Acylcarnitines with 12 or more carbon atoms in the acyl chain greatly enhanced nasal absorption of azetirelin: Bioavs with lauroylcarnitine chloride (LCC) and palmitoylcarnitine chloride were 96.9% and 72.9%, respectively. This enhancement by LCC plateaued at the low concentration of 0.1%. Conclusions. The basic nasal azetirelin formulation at pH 4.0 is stable and shows adequate absorption, with nasal absorption having greater Bioav than oral absorption. The 12-carbon acylate LCC was the strongest enhancer among acylcarnitines and provided near-total delivery of the administered dose to the blood.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    ISSN: 1573-904X
    Schlagwort(e): IL-1R type I ; microcalorimetry ; protein formulation ; stability ; aggregation ; preservatives ; far-uv circular dichroism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. To elucidate the solution conditions that confer stability of aqueous IL-1R using differential scanning calorimetry (DSC). Methods. Optimal pH conditions were determined by monitoring degradation products encountered during accelerated studies (at elevated temperatures) using SDS-PAGE. At the pH optimum, DSC screened for excipients that enhanced thermal stability by shifting the Tm to higher values. Using SEC the relationship between thermal unfolding and stability was investigated by considering if lower Tm's in the presence of preservatives correlated with degradation products at 37°C over time. The degree of aggregation relative to that of a control determined the level of stability achieved. Results. Circular dichroism (CD) measurements confirmed molecular modeling studies showing IL-1R to be about 39% β-sheet. Two major transitions characterized the DSC data with Tm's observed near 47°C and 66°C. Among 21 excipients screened, NaCl exhibited the greatest stabilizing influences based on shifting the low temperature transition to 53°C. The low temperature transition was later found to comprise two transitions, yielding a total of three melting transitions for IL-1R. High Tm's arising from the presence of preservatives correlated with the order of stability (i.e., 0.065% phenol 〉 0.1% m-Cresol 〉 0.9% benzyl alcohol). Conclusions. The three melting transitions are consistent in origin with the cooperative unfolding of three unique immunoglobulin-like domains of IL-1R. Optimal stability was achieved in 20 mM sodium citrate at pH 6 with sufficient NaCl to attain the tonicity of human serum. A correlation between the predicted ranking of stability and the extent of aggregation was demonstrated using DSC.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    ISSN: 1573-904X
    Schlagwort(e): perfluorodecalin ; nonaqueous suspension ; protein ; alpha interferon ; factor IX ; stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. To identify a suitable nonaqueous, parenterally acceptable suspending vehicle whereby a therapeutic protein is delivered as a stable flowable powder, making it amenable to delivery from sustained delivery systems maintained at body temperature. Methods. Formulations of plasma derived Factor IX (pdFIX) and recombinant human alpha interferon (rhα-lFN) were formulated as dry powders, suspended in various vehicles (perfluorodecalin, perfluorotributylamine, methoxyflurane, polyethylene glycol 400, soybean oil, tetradecane or octanol) and stored at 37°C. Stability was assessed by size exclusion chromatography, reverse phase chromatography, ion exchange chromatography, and bioassay, and was compared to the stability of dry powder formulations stored at 37°C and −80°C. Results. PdFIX was stable when stored at 37°C as a dry powder, or when the dry powder was suspended in the pharmaceutically acceptable vehicles perfluorodecalin or perfluorotributylamine. Suspensions of the powder in other pharmaceutically/parenterally acceptable vehicles such as soybean oil or PEG 400 resulted in aggregation and loss of bioactivity. A dry powder formulation of rhα-lFN suspended in perfluorodecalin was also stable at 37°C. Conclusions. This study shows the potential utility of perfluorinated hydrocarbons as nonaqueous suspending vehicles for long term in-vivo delivery of therapeutic proteins.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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