Skip to main content
SpringerLink
Log in

Thermal Analysis, Microcalorimetry and Combined Techniques for the Study of Pharmaceuticals

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

Modern thermal analysis, microcalorimetry and new emerging combined techniques which deliver calorimetric, microscopic and spectroscopic data offer a powerful analytical battery for the study of pharmaceuticals. These techniques are very useful in all steps of development of new drug products as well as methods for quality control in production. The characterization of raw materials enables to understand the relationships between polymorphs, solvates and hydrates and to choose the proper development of new drug products with very small amount of material in a very short time. Information on stability, purity is valuable for new entities as well as for marketed drug substances from different suppliers. Excipients which vary from single organic or inorganic entity to complexes matrixes or polymers need to be characterized and properly controlled. The thermodynamic phase-diagrams are the basis of the studies of drug-excipients interactions. They are very useful for the development of new delivery systems. A great number of new formulations need proper knowledge of the behaviour of the glass transition temperature of the components. Semi-liquid systems, interactions in aqueous media are also successfully studied by these techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. L. Ford and P. Timmins, Pharmaceutical Thermal Analysis, Ellis Horwood Books in Biological Sciences, Wiley, 1989, p.136.

  2. D. Giron, Acta Pharm. Jugosl., 40 (1990) 95.

    CAS  Google Scholar 

  3. D. Giron, J. Thermal Anal., 35 (1989) 1801.

    Article  CAS  Google Scholar 

  4. D. Giron, Thermal Analysis of Drugs and Drug Products, in Encyclopedia of Pharmaceutical Technology, 15 (1995) p. 1, J. Swarbrick and J. C. Boylan (eds), Marcel Dekker.

  5. D. Giron, Thermal analysis technologies, Pharm. Science and Technology today (PSST), 1 (1998) 191 and 262.

    Article  CAS  Google Scholar 

  6. D. Giron, Workshop on calibration of calorimeters, Torino, March 1998.

  7. D. Giron, Thermochim. Acta, 248 (1995) 1.

    Article  CAS  Google Scholar 

  8. International Conference on Harmonization (ICH) (1998) Guideline Specification Q6A, Decision Tree: Investigating the need to set acceptance criteria for polymorphism in drug substances and drug products.

  9. D. Giron, C. Goldbronn, S. Pfeffer and P. Piechon, Study of solvate formation in crystallization processes. PhandTA 3, eurostar, 1997.

  10. D. Giron, Proceed. 8th ICTA Suppl., 93 (1985).

  11. A. Burger and R. Ramberger, Mikrochim. Acta, 2 (1979) 259 and 273.

    Article  CAS  Google Scholar 

  12. D. Giron, M. Draghi, C. Goldbronn, S. Pfeffer and P. Piechon, J. Thermal Anal., 49 (1997) 913.

    Article  CAS  Google Scholar 

  13. E. Schwarz and J. De Buhr, Mettler Toledo TA-Applikationssamlung, Pharmazeutika, (1998) 56.

  14. S. S. Leung and D. J. W. Grant, J. Pharm.Sci., 86 (1997) 64.

    Article  CAS  Google Scholar 

  15. E. Laine, Acta Pharm. Fenn., 92 (1983) 243.

    CAS  Google Scholar 

  16. M. Sacchetti, J. Pharm. Sci., 87 (1998) 982.

    Article  CAS  Google Scholar 

  17. H. Ando, Drug Dev. Ind. Pharm., 21 (1995) 2227.

    CAS  Google Scholar 

  18. C. M. Adeyeye et al., Int. J. Pharm., 116 (1995) 65.

    Article  Google Scholar 

  19. H. Kitaoka, Chem. Pharm.Bull., 43 (1995) 1744.

    CAS  Google Scholar 

  20. D. Giron and C. Goldbronn, J.Thermal Anal., 49 (1997) 907 and 51 (1998) 727.

    Article  CAS  Google Scholar 

  21. G. Zografi et al., J. Pharm. Sci., 86 (1997) 346.

    Article  Google Scholar 

  22. K. Byström, Thermometric Application Note 22004 (1990).

  23. M. Anberg, C. Nystrom and S. Carstensson, Int. J. Pharm., 81 (1992) 153.

    Article  Google Scholar 

  24. G. Buckton, P. Darcy, D. Greenleaf and P. Holbrook, Int. J. Pharm., 116 (1995) and Int. J. Pharm., 130 (1996) 195.

    Google Scholar 

  25. D. Giron, P. Remy, S. Thomas and E. Vilette, J. Thermal Anal., 48 (1997) 465.

    Article  CAS  Google Scholar 

  26. D. Gao and J. H. Rytting, Int. J. Pharm., 151 (1997) 183.

    Article  CAS  Google Scholar 

  27. D. Giron and C. Goldbronn, J. Thermal Anal., 44 (1995) 217.

    CAS  Google Scholar 

  28. D. Giron, J. Pharm. and Biomed. Anal., 4 (1986) 755.

    Article  CAS  Google Scholar 

  29. D. Giron, C. Goldbronn and P. Picchon, J. Pharm. and Biomed. Anal., 7 (1989) 1421.

    Article  Google Scholar 

  30. J. Jacques, A. Collet and S. H. Wilen, Enantiomers, Racemates and Resolutions, Wiley, 1981.

  31. A. Salaman and T. Gray, Analysis Europa, June (1997) 26.

  32. K. Van der Voort Maarschalk, K. Zuurman, M. J. Van Steenbergen, W. E. Hennink, H. Vromans, G. K. Bolhuis and C. F. Lerk, Pharm. Res., 14 (1997) 415.

    Article  CAS  Google Scholar 

  33. N. Delahaye, R. Duclos and J. M. Saiter, Int. J. Pharm., 157 (1997) 27.

    Article  CAS  Google Scholar 

  34. G. Akovali and A. Ataly, Polymer Testing, 16 (1997) 165.

    Article  CAS  Google Scholar 

  35. D. Giron and C. Goldbronn, J. Thermal Anal., 48 (1997) 473.

    Article  CAS  Google Scholar 

  36. E. Schwarz and S. Pfeffer, J. Thermal Anal., 48 (1997) 557.

    Article  CAS  Google Scholar 

  37. D. Giron, A. Riva and M. Steiger, Thermochim. Acta, 85 (1985) 509.

    Article  CAS  Google Scholar 

  38. D. Giron, STP Pharma, 6 (1990) 87.

    CAS  Google Scholar 

  39. Y. Kaplun-Frischoff and E. Tonitou, J. Pharm. Sci., 86 (1997) 1394.

    Article  CAS  Google Scholar 

  40. M. J. Pikal, Biopharm., 3 (1990) 18 and 26.

    CAS  Google Scholar 

  41. R. M. Hatley, Dev. Bio. Stand., 74 (1991) 105; A. Martini, M. Crivellente, L. Muggetti, R. Artico and S. Kume, STP Pharm. Sci., 7 (1997) 377.

    Google Scholar 

  42. T. W. Randolph, J. Pharm. Sci., 86 (1997) 1198.

    Article  CAS  Google Scholar 

  43. A. I. Kim, M. J. Akers and S. L. Nail, J. Pharm. Sci., 87 (1998) 931.

    Article  CAS  Google Scholar 

  44. P. M. Mehl, J. Thermal Anal., 49 (1997) 817 (Tetralosc).

    Article  CAS  Google Scholar 

  45. H. E. Junginger, Polymer, 30 (1989) 1946.

    Article  Google Scholar 

  46. D. Clausse, I. Pezron and A. Gauthier, Fluid Phase Equilibria, 110 (1995) 137.

    Article  CAS  Google Scholar 

  47. D. Clausse, J. Thermal Anal., 51 (1998) 191.

    CAS  Google Scholar 

  48. E. C. A. Van Winden, W. Zhang and D. J. A. Crommelin, Pharm. Res., 14 (1997) 1151.

    Article  CAS  Google Scholar 

  49. P. L. Privalov, J. Chem. Thermodynamics, 29 (1997) 447.

    Article  CAS  Google Scholar 

  50. L. A. Collett and M. E. Brown, J. Therm. Anal. Cal., 51 (1998) 693.

    CAS  Google Scholar 

  51. A. Beezer and G. Buckton, Int. J. Pharm., 72 (1991) 181.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemical and Analytical Development, Novartis Pharma AG, 35 Lichtstrasse, Basel CH, 4002, Switzerland

    D. Giron

Authors
  1. D. Giron
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giron, D. Thermal Analysis, Microcalorimetry and Combined Techniques for the Study of Pharmaceuticals. Journal of Thermal Analysis and Calorimetry 56, 1285–1304 (1999). https://doi.org/10.1023/A:1010194020563

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1010194020563

Search

Navigation