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  • 1
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    Mapping the origins and expansion of the Indo-European language family (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-28
    Description: There are two competing hypotheses for the origin of the Indo-European language family. The conventional view places the homeland in the Pontic steppes about 6000 years ago. An alternative hypothesis claims that the languages spread from Anatolia with the expansion of farming 8000 to 9500 years ago. We used Bayesian phylogeographic approaches, together with basic vocabulary data from 103 ancient and contemporary Indo-European languages, to explicitly model the expansion of the family and test these hypotheses. We found decisive support for an Anatolian origin over a steppe origin. Both the inferred timing and root location of the Indo-European language trees fit with an agricultural expansion from Anatolia beginning 8000 to 9500 years ago. These results highlight the critical role that phylogeographic inference can play in resolving debates about human prehistory.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112997/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112997/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bouckaert, Remco -- Lemey, Philippe -- Dunn, Michael -- Greenhill, Simon J -- Alekseyenko, Alexander V -- Drummond, Alexei J -- Gray, Russell D -- Suchard, Marc A -- Atkinson, Quentin D -- 260864/European Research Council/International -- R01 GM086887/GM/NIGMS NIH HHS/ -- R01 HG006139/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 24;337(6097):957-60. doi: 10.1126/science.1219669.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science, University of Auckland, Auckland 1142, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22923579" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/history ; Bayes Theorem ; *Cultural Evolution ; History, Ancient ; Humans ; Language/*history ; Linguistics/history ; Phylogeography ; Turkey ; Vocabulary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Rise and fall of the Beringian steppe bison (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: The widespread extinctions of large mammals at the end of the Pleistocene epoch have often been attributed to the depredations of humans; here we present genetic evidence that questions this assumption. We used ancient DNA and Bayesian techniques to reconstruct a detailed genetic history of bison throughout the late Pleistocene and Holocene epochs. Our analyses depict a large diverse population living throughout Beringia until around 37,000 years before the present, when the population's genetic diversity began to decline dramatically. The timing of this decline correlates with environmental changes associated with the onset of the last glacial cycle, whereas archaeological evidence does not support the presence of large populations of humans in Eastern Beringia until more than 15,000 years later.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, Beth -- Drummond, Alexei J -- Rambaut, Andrew -- Wilson, Michael C -- Matheus, Paul E -- Sher, Andrei V -- Pybus, Oliver G -- Gilbert, M Thomas P -- Barnes, Ian -- Binladen, Jonas -- Willerslev, Eske -- Hansen, Anders J -- Baryshnikov, Gennady F -- Burns, James A -- Davydov, Sergei -- Driver, Jonathan C -- Froese, Duane G -- Harington, C Richard -- Keddie, Grant -- Kosintsev, Pavel -- Kunz, Michael L -- Martin, Larry D -- Stephenson, Robert O -- Storer, John -- Tedford, Richard -- Zimov, Sergei -- Cooper, Alan -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1561-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Henry Wellcome Ancient Biomolecules Centre, Oxford University, South Parks Road, Oxford OX13PS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567864" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Animals ; Bayes Theorem ; *Bison/classification/genetics ; Canada ; China ; *Climate ; DNA, Mitochondrial/genetics ; Environment ; *Fossils ; Genetic Variation ; Genetics, Population ; Human Activities ; Humans ; North America ; Phylogeny ; Population Dynamics ; Sequence Analysis, DNA ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-10-30
    Description: Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biankin, Andrew V -- Waddell, Nicola -- Kassahn, Karin S -- Gingras, Marie-Claude -- Muthuswamy, Lakshmi B -- Johns, Amber L -- Miller, David K -- Wilson, Peter J -- Patch, Ann-Marie -- Wu, Jianmin -- Chang, David K -- Cowley, Mark J -- Gardiner, Brooke B -- Song, Sarah -- Harliwong, Ivon -- Idrisoglu, Senel -- Nourse, Craig -- Nourbakhsh, Ehsan -- Manning, Suzanne -- Wani, Shivangi -- Gongora, Milena -- Pajic, Marina -- Scarlett, Christopher J -- Gill, Anthony J -- Pinho, Andreia V -- Rooman, Ilse -- Anderson, Matthew -- Holmes, Oliver -- Leonard, Conrad -- Taylor, Darrin -- Wood, Scott -- Xu, Qinying -- Nones, Katia -- Fink, J Lynn -- Christ, Angelika -- Bruxner, Tim -- Cloonan, Nicole -- Kolle, Gabriel -- Newell, Felicity -- Pinese, Mark -- Mead, R Scott -- Humphris, Jeremy L -- Kaplan, Warren -- Jones, Marc D -- Colvin, Emily K -- Nagrial, Adnan M -- Humphrey, Emily S -- Chou, Angela -- Chin, Venessa T -- Chantrill, Lorraine A -- Mawson, Amanda -- Samra, Jaswinder S -- Kench, James G -- Lovell, Jessica A -- Daly, Roger J -- Merrett, Neil D -- Toon, Christopher -- Epari, Krishna -- Nguyen, Nam Q -- Barbour, Andrew -- Zeps, Nikolajs -- Australian Pancreatic Cancer Genome Initiative -- Kakkar, Nipun -- Zhao, Fengmei -- Wu, Yuan Qing -- Wang, Min -- Muzny, Donna M -- Fisher, William E -- Brunicardi, F Charles -- Hodges, Sally E -- Reid, Jeffrey G -- Drummond, Jennifer -- Chang, Kyle -- Han, Yi -- Lewis, Lora R -- Dinh, Huyen -- Buhay, Christian J -- Beck, Timothy -- Timms, Lee -- Sam, Michelle -- Begley, Kimberly -- Brown, Andrew -- Pai, Deepa -- Panchal, Ami -- Buchner, Nicholas -- De Borja, Richard -- Denroche, Robert E -- Yung, Christina K -- Serra, Stefano -- Onetto, Nicole -- Mukhopadhyay, Debabrata -- Tsao, Ming-Sound -- Shaw, Patricia A -- Petersen, Gloria M -- Gallinger, Steven -- Hruban, Ralph H -- Maitra, Anirban -- Iacobuzio-Donahue, Christine A -- Schulick, Richard D -- Wolfgang, Christopher L -- Morgan, Richard A -- Lawlor, Rita T -- Capelli, Paola -- Corbo, Vincenzo -- Scardoni, Maria -- Tortora, Giampaolo -- Tempero, Margaret A -- Mann, Karen M -- Jenkins, Nancy A -- Perez-Mancera, Pedro A -- Adams, David J -- Largaespada, David A -- Wessels, Lodewyk F A -- Rust, Alistair G -- Stein, Lincoln D -- Tuveson, David A -- Copeland, Neal G -- Musgrove, Elizabeth A -- Scarpa, Aldo -- Eshleman, James R -- Hudson, Thomas J -- Sutherland, Robert L -- Wheeler, David A -- Pearson, John V -- McPherson, John D -- Gibbs, Richard A -- Grimmond, Sean M -- 13031/Cancer Research UK/United Kingdom -- 2P50CA101955/CA/NCI NIH HHS/ -- P01CA134292/CA/NCI NIH HHS/ -- P50 CA101955/CA/NCI NIH HHS/ -- P50 CA102701/CA/NCI NIH HHS/ -- P50CA062924/CA/NCI NIH HHS/ -- R01 CA097075/CA/NCI NIH HHS/ -- R01 CA97075/CA/NCI NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- Cancer Research UK/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2012 Nov 15;491(7424):399-405. doi: 10.1038/nature11547. Epub 2012 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23103869" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*metabolism ; Carcinoma, Pancreatic Ductal/*genetics/*pathology ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Genome/*genetics ; Humans ; Kaplan-Meier Estimate ; Mice ; Mutation ; Pancreatic Neoplasms/*genetics/*pathology ; Proteins/genetics ; Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Language phylogenies reveal expansion pulses and pauses in Pacific settlement (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-24
    Description: Debates about human prehistory often center on the role that population expansions play in shaping biological and cultural diversity. Hypotheses on the origin of the Austronesian settlers of the Pacific are divided between a recent "pulse-pause" expansion from Taiwan and an older "slow-boat" diffusion from Wallacea. We used lexical data and Bayesian phylogenetic methods to construct a phylogeny of 400 languages. In agreement with the pulse-pause scenario, the language trees place the Austronesian origin in Taiwan approximately 5230 years ago and reveal a series of settlement pauses and expansion pulses linked to technological and social innovations. These results are robust to assumptions about the rooting and calibration of the trees and demonstrate the combined power of linguistic scholarship, database technologies, and computational phylogenetic methods for resolving questions about human prehistory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, R D -- Drummond, A J -- Greenhill, S J -- New York, N.Y. -- Science. 2009 Jan 23;323(5913):479-83. doi: 10.1126/science.1166858.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19164742" target="_blank"〉PubMed〈/a〉
    Keywords: Bayes Theorem ; Databases, Factual ; *Emigration and Immigration/history ; History, Ancient ; Humans ; *Language ; Linguistics ; *Oceanic Ancestry Group/history ; Pacific Islands ; Philippines ; Phylogeny ; Polynesia ; Population Dynamics ; Taiwan ; Vocabulary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Speckle interferometry applied to asteroids and other solar system objects (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Speckle interferometry is a high angular resolution technique that allows study of resolved asteroids. By following the changing size, shape, and orientation of minor planets, and with a few general assumptions (e.g., geometric scattering, triaxial ellipsoid figures, no albedo features), it is possible to directly measure an asteroid's true dimensions and the direction of its spin axis in one or two nights. A particular subset of triaxial ellipsoid figures are equilibrium shapes, and would imply that some asteroids are thoroughly fractured. Such shapes if they exist among the asteroids would allow a determination of bulk density since there is a unique relation among spin period, size, shape, and density. The discovery of even a single rubble pile, (just as the finding of even one binary asteroid by speckle interferometric techniques) would drastically alter the notion of asteroids as small solid planets. The Pluto/Charon system was studied to aid in improving the orbital elements necessary to predict the eclipse/occultation season currently in progress. Four asteroids were reduced to their size, shape, and pole direction: 433 Eros, 532 Herculina, 511 Davida, and 2 Pallas.
    Keywords: ASTRONOMY
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 85-86
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  • 6
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    Worldwide photometry and lightcurve observations of 16 Psyche during the 1975-1976 apparition (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Twenty-six lightcurves of Psyche are presented together with UBV photometry and phase functions from 1975 and 1976. Combining photometric data from this opposition with those from previous apparitions resulted in a mean phase coefficient in V of 0.026 + or - 0.002 mag/deg. No significant phase-dependent variation in the U-B color could be determined from the data; the B-V color, however, displayed a reddening with phase of 0.0010 + or - 0.0004 mag/deg. It is concluded that compositional variations over Psyche's surface are minor, and that Psyche's opposition effect is typical of that for other well-observed asteroids. Psyche's behavior is accounted for if, to the first order, its shape is that of a triaxial ellipsoid with axial ratios near 5:4:3.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 54; April 19
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  • 7
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    Worldwide photometry and lightcurve observations of 1 Ceres during the 1975-1976 apparition (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Lightcurves and UBV photometry of Ceres from the 1975-1976 apparition are presented. The synodic period is 0.37812 + or 0.00004 day, the mean absolute V magnitude is 3.61 + or 0.03, and the phase coefficient is 0.040 + or - 0.001 mag/deg. The U-B and B-V phase coefficients are +0.0015 + or - 0.0007 and +0.0006 + or - 0.0003 mag/deg, respectively. The colors at zero phase are B-V = +0.70 + or - 0.01 and U-B = +0.41 + or 0.01.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 54; April 19
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  • 8
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    Speckle interferometry of asteroids. II - 532 Herculina (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Speckle interferometry of 532 Herculina performed on January 17 and 18, 1982, yields triaxial ellipsoid dimensions of (263 + or - 14) x (218 + or - 12) x (215 + or - 12) km, and a north pole for the asteroid within 7 deg of RA = 7h47min and DEC = -39 deg (ecliptic coordinates lambda = 132 deg beta = -59 deg). In addition, a 'spot' some 75 percent brighter than the rest of the asteroid is inferred from both speckle observations and Herculina's lightcurve history. This bright complex, centered at asterocentric latitude -35 deg, longitude 145-165 deg, extends over a diameter of 55 deg (115 km) of the asteroid's surface. No evidence for a satellite is found from the speckle observations, which leads to an upper limit of 50 km for the diameter of any satellite with an albedo the same as or higher than Herculina.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 61; 232-240
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  • 9
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    Speckle interferometry of asteroids. I - 433 Eros (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Analytical expressions are derived for the semimajor and semiminor axes and orientation angle of the ellipse projected by a triaxial asteroid, and the results are applied speckle-interferometry observations of the 433 Eros asteroid. The expressions were calculated as functions of the dimensions and pole of the body and of the asterocentric position of the earth and the sun. On the basis of the analytical expressions, the dimensions of 433 Eros are obtained. The light curve from December 18, 1981 is compared to the dimensions to obtain a geometric albedo of 0.156 (+ or - 0.010). A series of two-dimensional power spectra and autocorrelation functions for 433 Eros show that it is spinning in space.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 61; 132-151
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  • 10
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    Knox-Thompson images of 4 Vesta (1987)
    In:  Other Sources
    Details
    Publication Date: 2019-07-27
    Description: Reconstructed images of the asteroid 4 Vesta reveal dark and bright patterns which can be followed across the disk as the asteroid rotates. Reasonable agreement is found with its visible light curve by assigning relative albedo 0 to the three darkest features, and relative albedo 2 to the three brightest features. From power-spectrum analysis of sets of images at two different epochs, Vesta's triaxial principal diameters, the orientation of its pole, and its rotational rate and sense are obtained. The images confirm the dominant role of surface structure, particularly the dark spots, in determining Vesta's light-curve signature.
    Keywords: ASTRONOMY
    Type: Digital image recovery and synthesis; Aug. 17, 18, 1987; San Diego, CA; United States
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