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  • Humans  (20.062)
  • Hydrography
  • American Association for the Advancement of Science (AAAS)  (20.061)
  • Woods Hole Oceanographic Institution  (32)
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  • 1
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    CTD observations on the North Brazil shelf during A Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS) : November 1991 (2006)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: Hydrograhic (CTD) and acoustic Doppler current profiler (ADCP) observations were made on the North Brazil shelf adjacent to the mouth of the Amazon River during R/V Iselin cruise I9113 November 5-25, 1991 as part of A Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS). These observations were obtained during a large-scale survey on Leg 3 in support of geological and geochemical sampling, and during a frontal zone survey on Leg 4 consisting of 14 and 26 hourly CTD casts at anchored stations. The maximum sampling depth at each station was within two meters of the bottom. The primary objectives of the AMASSEDS hydrographic meaurement program were (a) to observe and characterize the temperature, salinity, density, oxygen, fluorescence and light transmission fields and their spatial variabilty on the north Brazilian shelf directly influenced by the Amazon River discharge, (b) to resolve the seaward extent and vertical structure of the surface plume of low salinity Amazon River water during different stages of river discharge, (c) to describe the spatial structure of the turbidity and associated suspended sediment distributions across the shelf, (d) to chacterize the properties of the Amazon shelf water beneath the surface plume and their seasonal variabilty, and (e) to describe the landward penetration of the North Brazil Current with respect to water properties and shelf currents. This report represents a summary in graphic and tabular form of the hydrograhic observations made during the fourth AMASSEDS cruise (I9113) on the R/V Iselin.
    Beschreibung: Funding was provided by the National Science Foundation through Grant No. OCE 88-12917.
    Schlagwort(e): Hydrography ; CTD ; Suspended sediment ; North Brazil Coastal Region ; Amazon River ; AmasSeds (A Multidisciplinary Amazon Shelf SEDiment Study) ; Equator ; Equatorial ; Columbus Iselin (Ship) Cruise CI9113
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 2
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    Can humans & coastal landforms co-exist? : proceedings of a workshop held at the Woods Hole Oceanographic Institution, Woods Hole, MA January 24, 2001 (2005)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: The primary objective of this publication is to share with a wider audience the valuable information and extensive dialogue that took place amongst over 140 individuals who attended the second in a series of planned workshops on the science and management of coastal landforms in Massachusetts. This workshop took place at the Woods Hole Oceanographic Institution on January 24, 2001. The individuals who attended this workshop are actively engaged in planning, managing, regulating, engineering, educating, and studying coastal landforms and their beneficial functions. This workshop titled, Can Humans & Coastal Landforms Co-exist?’, was a natural follow-up to a previous workshop, Coastal Landform Management in Massachusetts, held at WHOI October 9-10, 1997 (proceedings published as WHOI Technical Report #WHOI-98-16). The workshop had a very practical, applied focus, providing state-of-the-art scientific understanding of coastal landform function, case history management and regulation of human activities proposed on coastal landforms, a multi-faceted mock conservation commission hearing presented by practicing technical consultants and attorneys that involved all attendees acting as regulators in breakout sessions, and, at the conclusion of the workshop, an open discussion on all issues related to the science and management of coastal landforms, including future research needs.
    Beschreibung: Funding for these proceedings was provided by WHOI Sea Grant and the NOAA National Sea Grant College Program Office, Department of Commerce, under NOAA Grant No. M10-2, Woods Hole Oceanographic Institution Sea Grant Project No. NA86R60075.
    Schlagwort(e): Coastal ; Landforms ; Humans
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: 1574993 bytes
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  • 3
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    CTD observations on the North Brazil shelf during a multidisciplinary Amazon Shelf Sediment Study, AMASSEDS, May-June 1990 (2006)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: Hydrographic (CTD) and acoustic Doppler current profiler (ADCP) observations were made on the North Brazil shelf adjacent to the mouth of the Amazon River during R/V Iselin cruise I9004 May 23-June 13, 1990 as part of A Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS). These observations were obtained during a small-scale survey on Leg 1 in support of mooring deployment operations, during a large-scale survey on Leg 3 in support of geological and geochemical sampling, during a frontal zone survey on Leg 4 consisting of 12 and 24 hourly CTD casts at anchored stations, and during a bottom tripod recovery on Leg 5. The maximum sampling depth at each station was within two meters of the bottom. The primary objectives of the AMASSEDS hydrographic measurement program were (a) to observe and characterize the temperature, salinity, density, oxygen, fluorescence and light transmission fields and their spatial variabilty on the North Brazilian shelf directly influenced by the Amazon River discharge, (b) to resolve the seaward extend and vertical structure of the surface plume of low salinity Amazon River water during different stages of river discharge, (c) to describe the spatial structure of the turbidity and associate suspended sediment distributions across the shelf, (d) to characterize the properties of the Amazon shelf water beneath the surface plume and their seasonal variabilty, and (e) to describe the landward penetration of the North Brazil Current with respect to water properties and shelf currents. This report represents a summary in graphic and tabular form of the hydrographic observations made during the third AMASSEDS cruise (I9004) on the R/V Iselin.
    Beschreibung: Funding was provided by the National Science Foundation through Grant No. OCE 88-12917.
    Schlagwort(e): Hydrography ; CTD ; Suspended sediment ; AmasSeds (A Multidisciplinary Amazon Shelf SEDiment Study) ; North Brazil Coastal Region ; Columbus Iselin (Ship) Cruise CI9004
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 4
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    Nantucket shoals flux experiment (NSFE79) : part 2, moored array data report (2017)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: The Nantucket Shoals Flux Experiment (NSFE79) was conducted across the continental shelf and upper slope south of Nantucket from March, 1979 to April , 1980 to measure the flow of shelf water from the Georges Bank/Gulf of Maine region into the Middle Atlantic Bight. Conceived as a cooperative field experiment involving the Northeast Fisheries Center (NMFS), U.S. Geological Survey (Woods Hole), University of New Hampshire, and the Woods Hole Oceanographic Institution, the experiment contained two principal components, a moored array of current meter and bottom instrumentation deployed at six locations across the shelf and upper slope spanning a depth range from 46 m to 810 m, and a series of 27 hydrographic surveys made along or near the moored array line during the experiment. A basic description of the NSFE79 hydrographic data has been given in Part 1 by Wright (1983). A description of the moored array components and the basic moored array data sets is presented here in Part 2.
    Beschreibung: The NEFC participation was supported by the NMFS Marine Resources Monitoring, Assessment, and Prediction (MARt-1AP) Program. The U.S. Bureau of Land Management (BLM) supported the USGS field and analysis component under t~emoranda of Understanding M550-MU6-79, M551-MU8- 24, M551-MU9-4, and M551-MU0-18. The WHO! and UNH field programs were supported by the National Science Foundation under Grants OCE 78-19513 and OCE 78-26229.
    Schlagwort(e): Oceanography ; Hydrography ; Ocean currents ; Moored arrays
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 5
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    CTD observations on the North Brazil shelf during a Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS) : February - March 1990 (2006)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-25
    Beschreibung: Hydrographic (CTD) and acoustic Doppler current profiler (ADCP) observations were made on the North Brazil shelf adjacent to the mouth of the Amazon River during R/V Iselin cruise I9002 February 10-March 29, 1990 as part of A Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS). These observations were obtained during a small-scale survey on Leg 1 in support of mooring deployment operations, during a lage-scale survey on Leg 3 in support of geological and geochemical sampling, during a frontal zone survey on Leg 4 consisting of 12 and 24 hourly CTD casts at anchored stations, and during a bottom tripod recovery on Leg 5. The maximum sampling depth at each station was within two meters of the bottom. The primary objectives of the AMASSEDS hydrographic measurement program were (a) to observe and characterize the temperature, salinity, density, oxygen, fluorescence and light transmission fields and their spatial variability on the North Brazilian shelf directly influence by the Amazon River discharge, (b) to resolve the seaward extent and vertical structure of the surface plume of low salinity Amazon River water during different stages of river discharge, (c) to describe the spatial structure of the turbidity and associate suspended sediment distributions across the shelf, (d) to characterize the properties of the Amazon shelf water beneath the surface plume and their seasonal variability, and (e) to describe the landward penetration of the North Brazil Current with respect to water properties and shelf currents. This report represents a summary in graphic and tabular form of the hydrographic observations made during the seond AMASSEDS cruise (I9002) on the R/V Iselin.
    Beschreibung: Funding was provided by the National Science Foundation through Grant No. OCE 88-12917.
    Schlagwort(e): Hydrography ; CTD ; Suspended sediment ; AmasSeds (A Multidisciplinary Amazon Shelf SEDiment Study) ; North Brazil Coastal Region ; Columbus Iselin (Ship) Cruise CI9002
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: 10556762 bytes
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  • 6
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    Automated oxygen titration and salinity determination (2005)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: This report describes a newly developed automated Winkler titration system for dissolved oxygen in seawater which is presently in use at the Woods Hole Oceanographic Institution. This amperometric, calculated, endpoint system was compared with two different automated and one manual Winkler method during a recent cruise. The four different methods agreed to within about 0.04 ml/l. The system described here measures the titrant needed to reach the endpoint with a resolution better than 0.001 ml. The standard deviation of replicate samples is 0.005 ml/l and the accuracy is about 0.02 ml/l. A technique to automatically acquire conductivity ration measurements and calculate salinity using a Guildline Autosal Salinometer is also described.
    Beschreibung: Funding was provided by the National Science Foundation through Grant No. OCE88-22542.
    Schlagwort(e): Dissolved oxygen analysis ; Automated salinity analysis ; Hydrography
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: 1524697 bytes
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  • 7
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    CTD observations off northern California during the Shelf Mixed Layer Experiment, SMILE, November 1988 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: CTD observations on the R/V Wecoma cruise W8811 were made off the northern California coast November 13-24, 1988 as part of the .S.helf Mlxed Layer Experiment (SMILE). The survey consisted of repeated mappings of the central transect (C) through the SMILE moored array, and two synoptic sampling surveys-a large-scale grid of four cross-shelf transects extending to both sides ofPoint Arena and Point Reyes, and a small-scale grid of five cross-shelf transects located near the central SMILE mooring site. The small-scale hydrographic survey had a much higher spatial resolution of CTD stations than the large-scale survey. The primary objectives of the hydrographic measurement program were to observe and characterize the temperature, salinity, density, and light transmission fields and their temporal and spatial variability in the surface boundary layer along the continental shelf and slope near the SMILE moored array, and to acquire an estimate of the cross-shelf and along-shelf scales over which the mixed-layer depth varies. All of the cross-shelf transects extended beyond the shelf break and the maximum sampling depth at each station was near-bottom or 600 m. This report presents a summary in graphic and tabular form of the hydrographic observations made during cruise W8811 on the RN Wecoma.
    Beschreibung: Funding was provided by the National Science Foundation through grant Number OCE 87-16937
    Schlagwort(e): Shelf Mixed Layer Experiment (SMILE) ; Hydrography ; Wecoma (Ship) Cruise W8811
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 8
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    OBSANP data acquisition system : operator's manual and system overview (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: On the Ocean Bottom Seismometer Augmentation in the North Pacific Experiment (OBSANP, June-July, 2013, R/V Melville), a VLA and twelve OBSs were deployed to listen to an active acoustic source, a J15-3. This report describes the hardware and software used to control and record the acoustic transmissions from the source. Some significant features of the system are: 1) The system transmits general user-defined source functions, such as M-sequences (.SIO files). 2) In addition to controlling the source waveform, the system also records six real-time channels in binary files with user-selectable lengths: the monitor hydrophone mounted near the source, the power amplifier voltage and current, the depth of the source, Vref signal driving the power amplifiers and an IRIG-B time reference. Files are output in .AUV format with a precision GPSbased time stamp in the file name. 3) The transmission start time along with ADC and DAC sample rates are disciplined to GPS time. 4) A convenient, Labview based, user interface provides real-time source control and monitoring. 5) The software provides parsing and logging of gyro and GPS NMEA sentences. The system, which was based on an earlier system from Scripps MPL, worked well on OBSANP and is available for future projects.
    Beschreibung: Funding was provided by the Office of Naval Research under contract N00014-10-1-0987 and N00014-10-1-0510.
    Schlagwort(e): Melville (Ship) Cruise OBSANP ; Hydrography
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 9
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    Hydrographic data from R. V. Endeavor cruise 129 (2015)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Hydrographic and CTD data collected during R.V. Endeavor cruise 129 are presented. These data include temperature, salinity and dissolved oxygen observed at standard levels by a Neil Brown Instrument Systems' CTD-02 profiler and salinity, dissolved oxygen, silica, phosphate and nitrate values at the observed depths of the collected water samples. Ninety- two stations were occupied on two short sections within the Caribbean and one long meridional section at (nominally) 64° West from the British Virgin Islands to the 200 m depth contour south of Newfoundland. Also presented are a series of sectional profiles of the six observed parameters as a function of depth.
    Beschreibung: Funding was provided by the National Science Foundation under grant Number OCE 84-14243.
    Schlagwort(e): Endeavor (Ship: 1976-) Cruise EN129 ; Hydrography
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 10
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    Richardson number (RiNo) float operations during the Patch Experiment (PATCHEX), and data summary (2015)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: The Patch Experiment (PATCHEX) was a multi-ship experiment that took place in the area near 34 N, 127 W, between 8 and 27 October, 1986. The ships used in the experiment and their chief scientific objectives were the following: R/V THOMPSON, AMP (Advanced Microstructure Profiler) and MSP (micro-structure profiler) drops; USNS DESTEIGUER, ADCP (Acoustic Doppler current Profiler), seasoar and RiNo (Richardson Number) f loat operations; R/V POINT SUR, ADCP and towed fish; and FLIP, Acoustic Doppler and CTD profiling. This report describes the RiNo operations carried out on the USNS DESTEIGUER. Topics discussed include the RiNo float, the sensors used, how it was tracked, some of the preliminary results, and a log of the relevant parts of USNS DESTEIGUER Cruise #84.
    Beschreibung: Funding was provided by the Office of Naval Research through contract Number N00014-85-C-0001.
    Schlagwort(e): Patch Experiment ; Hydrography ; Oceanographic instruments ; Desteiguer (Ship) Cruise 84
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 11
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    Hydrographic data from R/V Endeavor cruise #90 (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: The final cruise of the NSF sponsored Warm Core Rings Program studied a Warm Core Ring (WCR) in the Fall of 1982 as it formed from a large northward meander of the Gulf Stream. This ring, known as 82-H or the eighth ring identified in 1982, formed over the New England Seamounts near 39.5°N, 65°W. Surveys using Expendable Bathythermographs, Conductivity-Temperature-DepthOxygen stations and Doppler Current Profiling provide a look at the genesis of a WCR. These measurements reveal that WCR 82-H separated from the Gulf Stream sometime between October 2-5. This ring was a typical WCR with a diameter of about 200 km and speeds in the high velocity core of 175 em/sec. Satellite imagery of 82-H following the cruise showed that it drifted WSW in the Slope Water region at almost 9 km/day, had at least one interaction with the Gulf Stream and was last observed on February 8, 1983 at 39°N, 72°W.
    Beschreibung: Funding was provided by the National Science Foundation under grant Number OCE 80- 16983 and by the National Aeronautical and Space Administration under Grant Number NAGW-272.
    Schlagwort(e): Hydrography ; Endeavor (Ship: 1976-) Cruise EN90
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 12
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    Automated oxygen titration and salinity determination (2006)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: This report describes a newly developed automated Winkler titration system for dissolved oxygen in seawater which is presently in use at the Woods Hole Oceanographic Institution. This amperometric, calculated endpoint system was compared with two different automated and one manual Winkler method during a recent cruise. The four different methods agreed to within about 0.04 ml/l. The system described here measures the titrant needed to reach the endpoint with a resolution better than 0.001 ml. The standard deviation of replicate samples is 0.005 ml/l and the accuracy is about 0.02 ml/l. A technique to automatically acquire conductivity ratio measurements and calculate salinity using a Guildline Autosal Salinometer is also describe.
    Beschreibung: Funding was provided by the National Science Foundation through Grant No. OCE88-22542.
    Schlagwort(e): Dissolved oxygen analysis ; Automated salinity analysis ; Hydrography
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: 1542542 bytes
    Format: application/pdf
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  • 13
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    CLIMODE Subsurface Mooring Report : November 2005 - November 2007 (2013)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Two years of temperature, salinity, current, and nutrient data were collected on four subsurface moorings as part of the 2 year field component of the CLIMODE experiment. The moorings were located in North Atlantic’s subtropical gyre, south-east of the Gulf Stream. Two moorings, the most heavily instrumented, were close to the Gulf Stream, in the region where cold air outbreaks force large air-sea fluxes and where Eighteen Degree Water outcrops. Two other moorings were located farther south and carried more limited instrumentation. The moorings were initially deployed in November of 2005, turned around in November of 2006 and finally recovered in November of 2007. During the first year, the moorings close to the Gulf Stream suffered considerable blow down, and some of the instruments failed. During the second year, the blow down was greatly reduced and most instruments collected a full year worth of data.
    Beschreibung: Funding was provided by the Division of Ocean Sciences of the National Science Foundation under Grant No. OCE-0424536.
    Schlagwort(e): Hydrography ; CLIvar MOde Water Dynamic Experiment (CLIMODE) ; Oceanus (Ship : 1975-) Cruise OC419 ; Oceanus (Ship : 1975-) Cruise OC434 ; Oceanus (Ship : 1975-) Cruise OC442 ; Atlantis (Ship : 1996-) Cruise AT13
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
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  • 14
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    CTD observations in the Great South Channel during the South Channel Ocean Productivity Experiment, SCOPEX, May-June 1989 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: CTD and acoustic Doppler current profiler (ADCP) observations were made in the Great South Channel (GSC) off the New England coast during R/V Endeavor cruise EN196 May 18 to June 12, 1989 as part of the South Channel Ocean Productivity EXperiment (SCOPEX). These observations were obtained using several sampling plans - a series of small-scale surveys in support of biological sampling and a large-scale survey of five cross-channel transects extending from Nantucket Shoals and the coast of Cape Cod to Georges Bank. The maximum sampling depth at each station was within a few meters of the bottom. The primary objectives of the hydrographic measurement program were to a) observe and characterize the temperature, salinity, density, oxygen, fluorescence and light transmission fields and their spatial variability in the Great South Channel off the New England coast, (b) resolve the low salinity surface plume-like structure usually observed east of Cape Cod in late spring, (c) define the front or boundary between the vertically well-mixed water over Nantucket Shoals, the GSC, Georges Bank, and the stratified water in the deeper southwestern Gulf of Maine, and (d) characterize water properties in regions of enhanced biological productivity. This report presents a summary in graphic and tabular form of the hydrographic observations made during cruise EN196 on the R/V Endeavor.
    Beschreibung: Funding was provided by the National Science Foundation through Grant Number 87-13988
    Schlagwort(e): South Channel Ocean Productivity Experiment ; Hydrography ; Endeavor (Ship: 1976-) Cruise EN196
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    Materialart: Technical Report
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  • 15
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    Hydrographic and nutrient data from R/V Knorr cruise 73, leg 2 : February to March, 1978 : off the coast of Peru (2011)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: In February and March of 1978 a major cruise was undertaken on the R/V KNORR off the Peruvian coast near 15°S in order to investigate the organic biogeochemical processes associated with upwelling areas. The purpose of this report is to collate the large amount of hydrographic, nutrient, and plankton data generated from various investigators on this cruise and use the report as a standard for the cruise participants. Data for temperature, salinity, oxygen, nitrate, nitrite, ammonium, phosphate, silicate, chlorophyll a, productivity indices, and carbon fixation rates are given.
    Beschreibung: Prepared for the National Science Foundation under Grant OCE 77-26084, for the Office of Naval Research under Contract N00014-74-C-0262 ER 083-004 and for the NOAA Office of Sea Grant under Grants 04-7-158-44034 and 04-8-MO1-79 to the University of New Hampshire/University of Maine Cooperative Institutional Sea Grant Proqram.
    Schlagwort(e): Knorr (Ship : 1970-) Cruise KN73-2 ; Hydrography ; Oceanography
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    Materialart: Technical Report
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  • 16
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    CTD observations on the North Brazil shelf during a multidisciplinary Amazon Shelf Sediment Study, AMASSEDS, August 1989 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: CTD and acoustic Doppler current profiler (ADCP) observations were made on the North Brazil shelf adjacent to the mouth of the Amazon River during R/V Iselin cruise I8909 August 3-14, 1989 as part of A Multidisciplinary Amazon Shelf SEDiment Study (AMASSEDS). These observations were obtained during a large-scale survey in support of geological and geochemical sampling, an anchored time series station consisting of 26 hourly CTD casts, and one transect which was repeated off the mouth of the Amazon River. The maximum sampling depth at each station was within two meters of the bottom. The primary objectives of the AMASSEDS hydrographic measurement program were to (a) observe and characterize the temperature, salinity, density, oxygen, fluorescence and light transmission fields and their spatial variability on the north Brazilian shelf directly influenced by the Amazon River discharge, (b) resolve the seaward extent and vertical structure of the surface plume of low salinity Amazon River water during different stages of river discharge, (c) describe the spatial structure of the turbidity and associated suspended sediment distributions across the shelf, (d) characterize the properties of the Amazon shelf water beneath the surface plume and their seasonal variability, and (e) describe the landward penetration of the North Brazil Current (NBC) with respect to water properties and shelf currents. This report represents a summary in graphic and tabular form of the hydrographic observations made during the first AMASSEDS cruise (I8909) on the R/V Iselin.
    Beschreibung: Funding was provided by the National Science Foundation through Grant Number OCE 88-12917
    Schlagwort(e): Amazon Shelf Sediment Study ; Hydrography ; Marine sediments ; Columbus Iselin (Ship) Cruise CI8909
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    Materialart: Technical Report
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  • 17
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    Exploring the North Atlantic Ocean on floppy disks (2015)
    Woods Hole Oceanographic Institution
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    Publikationsdatum: 2022-05-26
    Beschreibung: Data from four floppy disks found in the zip file
    Beschreibung: A selection of hydrographic station data in the Atlantic between 8°S and 70°N is packed on four 5 1/4" floppy disks. Sample utility programs for reading and plotting the data are also on the disks. We present this computer atlas in preliminary form for use by students and professionals, in the belief that easy access to this valuable historical data will be educational and stimulating.
    Beschreibung: Funding was provided by the Office of Naval Research under contract Number N00014-84-C-0134, and the National Science Foundation through grant Number OCE86-13810.
    Schlagwort(e): Hydrography
    Repository-Name: Woods Hole Open Access Server
    Materialart: Technical Report
    Format: application/zip
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  • 18
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    Hydrographic station data obtained in the East China Sea, June, 1980 (2017)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Three surveys were made during June, 1980 on the R/V Oceanographer to measure the regional hydrographic structure in the East China Sea near the mouth of the Chang Jiang (Yangtze) River. The objective of the hydrographic program was to document the spatial and temporal structure of the Chang Jiang plume over the continental shelf and characterize the river's influence on the shelf water masses. A summary of the hydrographic observations made during Cruise RP-05-0C-80 on the R/V Oceanographer is presented in graphic form.
    Beschreibung: Prepared for the National Atmospheric and Oceanic Administration under Cooperative Agreement NA81AA-H-00008 and for the National Science Foundation under Grant OCE-80-14941.
    Schlagwort(e): Oceanography ; Hydrography ; Oceanographer (Ship) Cruise
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    Materialart: Technical Report
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  • 19
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    Stratus 15 fifteenth setting of the Stratus Ocean Reference Station cruise on board RV Cabo de Hornos June 15 – 29, 2016 Valparaiso, Chile – Valparaiso, Chile (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: The Ocean Reference Station at 20°S, 85°W under the stratus clouds west of northern Chile is being maintained to provide ongoing climate-quality records of surface meteorology, air-sea fluxes of heat, freshwater, and momentum, and of upper ocean temperature, salinity, and velocity variability. The Stratus Ocean Reference Station (ORS Stratus) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Climate Observation Program. It is recovered and redeployed annually, with past cruises that have come between October and May. This cruise was conducted on the Chilean research vessel Cabo de Hornos. During the 2016 cruise on the Cabo de Hornos to the ORS Stratus site, the primary activities were the recovery of the previous (Stratus 14) WHOI surface mooring, deployment of the new Stratus 15 WHOI surface mooring, in-situ calibration of the buoy meteorological sensors by comparison with instrumentation installed on the ship, CTD casts near the moorings. Surface drifters and ARGO floats were also launched along the track.
    Beschreibung: Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA14OAR4320158
    Schlagwort(e): Hydrography ; Oceanographic instruments ; Cabo de Hornos (Ship) Cruise Stratus 15
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    Materialart: Technical Report
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  • 20
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    A compilation and description of hydrographic transects of the Mid-Atlantic Bight shelf-break front (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Historical hydrographic transects of the Mid-Atlantic Bight shelf-break front are compiled by month and described in this report. Interannual variability of the meteorological forcing and slope water mass properties are presented as an aid in interpreting the variability of the frontal structure. Descriptions of the significant features of the front, shelf and slope water masses precede the compiled transects. The sections are limited to the upper 350 m of the water column and a cross-shore extent of 280m.
    Beschreibung: Funding was provided by the Department of Energy under contract DE-AC02-79EV10005
    Schlagwort(e): Continental shelf ; Hydrography
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    Materialart: Technical Report
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  • 21
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    NTAS 16 sixteenth setting of the NTAS Ocean Reference Station cruise on board RV Endeavor January 21 - February 8, 2017 Narragansett, Rhode Island - San Juan, Puerto Rico (2018)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: The Northwest Tropical Atlantic Station (NTAS) was established to address the need for accurate air-sea flux estimates and upper ocean measurements in a region with strong sea surface temperature anomalies and the likelihood of significant local air–sea interaction on inter-annual to decadal timescales. The approach is to maintain a surface mooring outfitted for meteorological and oceanographic measurements at a site near 15N, 51W by successive mooring turnarounds. These observations are used to investigate air–sea interaction processes related to climate variability. The NTAS Ocean Reference Station (ORS NTAS) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Ocean Observing and Monitoring Division. This report documents recovery of the NTAS-15 mooring and deployment of the NTAS-16 mooring. Both moorings used Surlyn foam buoys as the surface element. These buoys were outfitted with two Air–Sea Interaction Meteorology (ASIMET) systems. Each system measures, records, and transmits via Argos satellite the surface meteorological variables necessary to compute air–sea fluxes of heat, moisture and momentum. The upper 160 m of the mooring line were outfitted with oceanographic sensors for the measurement of temperature, salinity and velocity. The mooring turnaround was done by the Upper Ocean Processes Group of the Woods Hole Oceanographic Institution (WHOI), onboard R/V Endeavor (cruise EN590). The cruise took place between January 21 and February 8 2017. The NTAS-16 mooring was deployed on January 30, and the NTAS-15 mooring was recovered on January 31. A 24-hour intercomparison period was conducted on January 29 in front of the NTAS 15 buoy, and again on February 1 in front of the NTAS 16 buoy. During the inter-comparisons, data from instrumentation on the buoys, telemetered through Argos satellite system, and the ship’s meteorological and oceanographic measurements were monitored while the ship was stationed 0.2 nm downwind of the buoys. This report describes these operations, as well as other work done on the cruise and some of the pre-cruise buoy preparations. Other operations during EN590 consisted in the recovery and deployment of the Meridional Overturning Variability Experiment (MOVE) Pressure Inverted Echo Sounders (PIES) at two MOVE arrays (MOVE 1 in the east, and MOVE 3 in the west near Guadeloupe). Acoustic downloads of data from (PIES) and subsurface mooring (MOVE1, 3 and 4) were also conducted. MOVE is designed to monitor the integrated deep meridional flow in the tropical North Atlantic.
    Beschreibung: Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA14OAR4320158.
    Schlagwort(e): Hydrography ; Oceanographic instruments ; Meteorology ; Endeavor (Ship: 1976-) Cruise EN590
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    Materialart: Technical Report
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  • 22
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    The Long Term Upper Ocean Study (Lotus) : cruise summary and hydrographic data report : Endeavor 97, April 1983 (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: ENDEAVOR cruise number 97 (8-19 April, 1983) was the ninth scheduled cruise to the Long Term Upper Ocean Study (LOTUS) area centered at 34°N, 70°W. During the cruise three LOTUS moorings (a near-surface and two subsurface moorings) deployed eleven months earlier were recovered and replaced by a nearly identical set of moorings. The new array will remain in the water during the final year of LOTUS field work. The LOTUS surface mooring, scheduled to be recovered during ENDEAVOR 97, had been partially recovered one month earlier after the mooring parted and drifted off station. The lower portion of the surface mooring which went to the bottom when the mooring failed was successfully recovered during ENDEAVOR 97. A new surface mooring replacing the one that parted and a C. S. Draper Labs profiling current meter mooring were also set during the cruise. Non-mooring work included deploying three satellite tracked drifter buoys and completing five CTD stations in the LOTUS area. Several inter-comparisons between shipborne meteorological sensors and similar sensors on the LOTUS surface buoy and the drifter buoys were made. An XBT section was also completed along 70°W between 40°N and 34°N. Part I of this report is a summary of the major cruise activities and part II presents the hydrographic data (CTD and XBT) collected during the cruise.
    Beschreibung: This work was supported by the Office of Naval Research under Contract No. 000014-76-C-0197, NR 083-400.
    Schlagwort(e): Oceanography ; Hydrography ; Endeavor (Ship: 1976-) Cruise EN97
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    Materialart: Technical Report
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  • 23
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    The Long Term Upper Ocean Study (Lotus) : cruise summary and hydrographic data report, Oceanus 129--October 1982 (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: OCEANUS cruise number 129 (28 October-4 November, 1982) was the eighth in a series of cruises to the Long Term Upper Ocean Study (LOTUS) area centered at 34°N, 70°W. In the LOTUS area seven SOFAR floats were launched, two moorings were recovered (a LOTUS surface mooring and a C. S. Draper Labs profiling current meter mooring), and a surface mooring which replaced the one recovered was set. Seven CTD stations were also completed in the LOTUS area. Outside the LOTUS area a subsurface mooring was set in the Gulf Stream in cooperation with H. Bryden's (WHOI) Gulf Stream Observations project, and a WHOI engineering mooring at Site D was recovered, examined and redeployed. In addition several XBT sections were made, one along 70°W between 40°N and 34°N, a second surveyed a cold core ring discovered during the trip to the LOTUS area and a third was made in the vicinity of the Gulf Stream Observations mooring. Part I of this report is a summary of the major cruise activities and part II presents the hydrographic data (CTD and XBT) collected during the cruise.
    Beschreibung: This work was supported by the Office of Naval Research under Contract No. N00014-76-C-0197, NR083-400.
    Schlagwort(e): Oceanography ; Hydrography ; Oceanus (Ship : 1975-) Cruise OC129
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    Materialart: Technical Report
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  • 24
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    Lake Kivu expedition : geophysics, hydrography, sedimentology (preliminary report) (2008)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: In March 1971, seven members of the Woods Hole Oceanographic Institution were engaged in a multidisciplinary study of Lake Kivu. This expedition represents part of a long-range program concerned with the structural and hydrographical settings of the East African Rift Lakes and their relationships to the Red Sea and the Gulf of Aden Rifts. The program started in May 1963 with a geophysical study on Lake Malawi (von Herzen and Vacquier, 1967). Several expeditions of our Institution into the Red Sea and Gulf of Aden area in 1964, 1965 and 1966 (Degens and Ross, 1969) provided detailed geological information on the "northern" extension of the East African Rift. And finally our study of last year on Lake Tanganyika c1osed a major gap in the program; it allowed us to out1ine a model on the evolution of a rift which starts with (i) bulging of the earth's crust, (ii) block-faulting, (iii) volcanism and hydrothermal activity, and which has its final stage in (iv) sea floor spreading (Degens et al. 1971). In the case of Lake Tanganyika, only the second stage of this evolution series has been reached, i.e. block-faulting. In contrast, the Red Sea and the Gulf of Aden had already evolved to active sea floor spreading, almost 25 million years ago. Somewhere along the line between Lake Tanganyika and the Gulf of Aden must lie the "missing link" of this evolution series. Lake Kivu, almost 100 miles to the north of Lake Tanganyika is situated at the highest point of the Rift Valley and is surrounded by active volcanoes and geothermal springs. As recently as 1944, lava flows reached the lake shore. This lake was therefore, a natural choice to test our hypothesis on the origin and development of rifts. Furthermore, the occurrence of large quantities of dissolved gases, e.g., CO2 and methane, represented an interesting geochemical phenomenon worthwhile to investigate.
    Beschreibung: Supported by the National Science Foundation with Grants GA 19262, GB 20956, and GU 3927; grants from the Petroleum Research Fund of the American Chemical Society PRF#1943A2; and by private research funds of the Woods Hole Oceanographic Institution.
    Schlagwort(e): Geophysics ; Hydrography ; Sedimentology
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    Materialart: Technical Report
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  • 25
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    Hydrographic and nutrient data from R/V Atlantis II cruise 108, leg 3 : March to April 1981 : off the coast of Peru (2011)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: In March and April of 1981 a major cruise was undertaken on the R/V Atlantis II off the Peruvian coast near 15°S in order to investigate the sea-air exchange of selected heavy metals and natural and anthropogenic organic compounds. The purpose of this report is to collate the hydrographic, nutrient, and plankton data generated from various investigators on this cruise end to provide a standard of reference for the cruise participants. Data for temperature, salinity, oxygen, nitrate, nitrite, axnmonium, phosphate, silicate, chlorophyll a, particulate organic carbon, and particulate organic nitrogen are given. In addition, air and sea temperatures, and wind speed and direction data, collected using the SAIL system, are included.
    Beschreibung: Prepared for the National Science Foundation under Grants OCE 77-12914, OCE 80-17877 and OCE 81-11947.
    Schlagwort(e): Atlantis II (Ship : 1963-) Cruise AII108-3 ; Oceanography ; Hydrography
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    Materialart: Technical Report
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  • 26
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    CTD observations off Northern California during the Shelf Mixed Layer Experiment, SMILE, February/March 1989 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: CTD observations were made off the northern California coast during R/V Wecoma cruise W8902 February 22- March 10, 1989 as part of the Shelf Mixed Layer Experiment (SMILE). The surveys consisted of three sampling plans- a large-scale grid of four cross-shelf transects extending to both sides of Point Arena and Point Reyes, a small-scale grid of five cross-shelf transects located near the central SMILE mooring site, and an expanded small-scale grid of nine cross-shelf transects. All of the cross-shelf transects extended beyond the shelf break and the maximum sampling depth at each station was near-bottom or 1000 m. The average along-shelf separation between cross-shelf transects was about 15 km for the small-scale surveys and 50 km for the large-scale grid. The primary objectives of the hydrographic measurement program were to observe and characterize the temperature, salinity, density, and light transmission fields and their temporal and spatial variability in the surface boundary layer along the continental shelf and slope near the SMILE moored array, and to acquire estimates of the cross- and along-shelf scales over which the mixed-layer depth varies. This report presents a summary in graphic and tabular form of the hydrographic observations made during cruise W8902 on the R/V Wecoma.
    Beschreibung: Funding was provided by the National Science Foundation through Grant Number OCE 87-16937
    Schlagwort(e): Shelf Mixed Layer Experiment (SMILE) ; Hydrography ; Wecoma (Ship) Cruise W8902
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    Materialart: Technical Report
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  • 27
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    CTD observations off northern California during the Shelf Mixed Layer Experiment, SMILE, May 1989 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: CTD observations were made off the northern California coast during R/V Wecoma cruise W8905 May 5-14, 1989 as part of the Shelf Mixed Layer Experiment (SMILE). The surveys consisted of two sampling plans - a large-scale grid of four cross-shelf transects extending to both sides of Point Arena and Point Reyes, and a small-scale grid of six cross-shelf transects located near the central SMILE mooring site. All of the cross-shelf transects extended beyond the shelf break and the maximum sampling depth at each station was near-bottom or 1500 m. The average along-shelf separation between cross-shelf transects was about 15 km for the small-scale surveys and 50 km for the large-scale grid. The primary objectives of the hydrographic measurement program were to observe and characterize the temperature, salinity, density, and light transmission fields and their temporal and spatial variability in the surface boundary layer along the continental shelf and slope near the SMILE moored array, and to acquire estimates of the cross- and along-shelf scales over which the mixed-layer depth varies. This report presents a summary in graphic and tabular form of the hydrographic observations made during cruise W8905 on the R/V Wecoma.
    Beschreibung: Funding was provided by the National Science Foundation through Grant Number OCE 87-16937
    Schlagwort(e): Shelf Mixed Layer Experiment (SMILE) ; Hydrography ; Wecoma (Ship) Cruise W8905
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    Materialart: Technical Report
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  • 28
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    WHOI Hawaii Ocean Timeseries Station (WHOTS) : WHOTS-10 2013 mooring turnaround cruise report (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: The Woods Hole Oceanographic Institution (WHOI) Hawaii Ocean Timeseries Site (WHOTS), 100 km north of Oahu, Hawaii, is intended to provide long-term, high-quality air-sea fluxes as a part of the NOAA Climate Observation Program. The WHOTS mooring also serves as a coordinated part of the Hawaii Ocean Timeseries (HOT) program, contributing to the goals of observing heat, fresh water and chemical fluxes at a site representative of the oligotrophic North Pacific Ocean. The approach is to maintain a surface mooring outfitted for meteorological and oceanographic measurements at a site near 22.75°N, 158°W by successive mooring turnarounds. These observations will be used to investigate air–sea interaction processes related to climate variability. This report documents recovery of the ninth WHOTS mooring (WHOTS-9) and deployment of the tenth mooring (WHOTS-10). Both moorings used Surlyn foam buoys as the surface element and were outfitted with two Air–Sea Interaction Meteorology (ASIMET) systems. Each ASIMET system measures, records, and transmits via Argos satellite the surface meteorological variables necessary to compute air–sea fluxes of heat, moisture and momentum. The upper 155 m of the moorings were outfitted with oceanographic sensors for the measurement of temperature, conductivity and velocity in a cooperative effort with R. Lukas of the University of Hawaii. A pCO2 system and ancillary sensors were installed on the buoys in cooperation with Chris Sabine at the Pacific Marine Environmental Laboratory. A set of radiometers were installed in cooperation with Sam Laney at WHOI. The WHOTS mooring turnaround was done on the NOAA ship Hi’ialakai by the Upper Ocean Processes Group of the Woods Hole Oceanographic Institution. The cruise took place between 9 and 16 July 2013. Operations began with deployment of the WHOTS-10 mooring on 10 July. This was followed by meteorological intercomparisons and CTDs. Recovery of the WHOTS-9 mooring took place on 14 July. This report describes these cruise operations, as well as some of the in-port operations and pre-cruise buoy preparations.
    Beschreibung: Funding was provided by the National Oceanic and Atmospheric Administration under Grant. No. NA090AR4320129 and the Cooperative Institute for the North Atlantic Region (CINAR)
    Schlagwort(e): Hydrography ; Hi'ialakai (Ship) Cruise WHOTS-10
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    Materialart: Technical Report
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  • 29
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    Hydrographic data from R/V Endeavor cruise #143 (2014)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Hydrographic data collected during R/V Endeavor cruise 143 is presented as a preliminary study of subduction in the northeast Atlantic south of the Azores Front. The front is clearly defined at the northern end of CTD section #1 which also shows a layer of 16-18°C water subducted to the south. Section #2, 280 km to the east, is dominated by a large cyclonic ring with characteristics similar to 'eastern' rings reported earlier . An anomalously salty parcel of Mediterranean water in this section is typical of highly saline lenses seen in the Canary Basin.
    Beschreibung: Funding was provided by the National Science Foundation under grant Nos. OCE 85-15642 and OCE 85-18372.
    Schlagwort(e): Endeavor (Ship: 1976-) Cruise EN143 ; Oceanography ; Hydrography
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    Materialart: Technical Report
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  • 30
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    Hydrographic station data obtained in the vicinity of Georges Bank, May and August, 1976 (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Two extended cruises were made during May and August, 1976, to measure the regional hydrographic structure in the vicinity of Georges Bank on the New England Continental Shelf. A summary of the hydrographic observations made during Cruise E2B76 on the R/V Eastward and leg 3 of Cruise 13 on the R/V Oceanus are presented in graphic form.
    Beschreibung: Prepared for the United States Geological Survey under Contract No. 14-08-0001-15615 and for· the National Science Foundation under Grant OCE-76-01813 (WHOI).
    Schlagwort(e): Hydrography ; Ocean temperature ; Salinity ; Eastward (Ship) Cruise E2B76 ; Oceanus (Ship : 1975-) Cruise OC13
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    Materialart: Technical Report
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  • 31
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    Hydrographic station data obtained in the vicinity of Nantucket Shoals, May, July, September 1978 (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Three cruises were made during May, July, and September 1978, to measure the regional hydrographic structure in the vicinity of Nantucket Shoals on the New England Continental Shelf. A summary of the hydrographic observations made during Cruise NSl, NS2, and NS3 on the R/V EDGERTCN is presented in graphic form.
    Beschreibung: Prepared with funds from the Department of Commerce, NOAA Office of Sea Grant under Grant #04- 7-158-44104 and #04-8-M01-149.
    Schlagwort(e): Hydrography ; Oceanography ; Edgerton (Ship) Cruise NS1 ; Edgerton (Ship) Cruise NS2 ; Edgerton (Ship) Cruise NS3
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    Materialart: Technical Report
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  • 32
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    Hydrographic data from R.V. Oceanus cruise 133, leg VII (2016)
    Woods Hole Oceanographic Institution
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: Hydrographic data collected during R.V. Oceanus cruise 133, leg VII are presented. These data include temperature, salinity and dissolved oxygen observed at standard levels by a Neil Brown Instrument Systems' CTD-02 profiler and salinity, dissolved oxygen, silicate, phosphate and nitrate values at the observed depths of the collected water samples. Ninety-four stations were occupied on a meridional section at (nominally) 52°West from Brazil to Greenland. Also presented are a series of sectional profiles of the six observed parameters as a function of depth.
    Beschreibung: Funding was provided by the National Science Foundation under grant Number OCE 80-15789.
    Schlagwort(e): Oceanography ; Hydrography ; Oceanus (Ship : 1975-) Cruise OC133-7
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    Materialart: Technical Report
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  • 33
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    HIV-1 diversity and vaccine development (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-07-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, Gary -- Makgoba, William -- Esparza, Jose -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2335.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12090274" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *AIDS Vaccines/immunology ; Clinical Trials as Topic ; Developing Countries ; *Genetic Variation ; HIV Antibodies/immunology ; HIV Infections/epidemiology/immunology/prevention & control ; HIV-1/*genetics/*immunology ; Humans
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    The development of electroporation (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heller, Richard -- New York, N.Y. -- Science. 2002 Jan 11;295(5553):277.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11789539" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Electroporation ; Genetic Therapy/*methods ; Humans ; Transfection/*methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Cancer. BRCA2 enters the fray (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-09-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, John H -- Elledge, Stephen J -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1822-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228708" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; BRCA1 Protein/metabolism ; BRCA2 Protein/*chemistry/*metabolism ; Binding Sites ; Breast Neoplasms/genetics ; Crystallography, X-Ray ; DNA/*metabolism ; DNA Damage ; *DNA Repair ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/metabolism ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Mice ; Ovarian Neoplasms/genetics ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rad51 Recombinase ; Rats ; Recombination, Genetic ; Replication Protein A
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Genetics. Please don't call it cloning! (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-02-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogelstein, Bert -- Alberts, Bruce -- Shine, Kenneth -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1237.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA. vogelbe@welch.jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847324" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bioethical Issues ; Cell Line ; *Cloning, Organism/legislation & jurisprudence ; Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; *Nuclear Transfer Techniques ; *Stem Cells ; *Terminology as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Transcription. Unlocking the gates to gene expression (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fry, Christopher J -- Peterson, Craig L -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1847-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. craig.peterson@umassmed.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884741" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylation ; Acetyltransferases/*metabolism ; Cell Differentiation ; Chromatin/chemistry/*metabolism ; Enterocytes/cytology/metabolism ; *Gene Expression Regulation ; Genes, Fungal ; Histone Acetyltransferases ; Histones/metabolism ; Humans ; Interferon-beta/genetics ; Models, Genetic ; Nucleosomes/chemistry/*metabolism ; Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; *Saccharomyces cerevisiae Proteins ; Transcription Factors/*metabolism ; *Transcription, Genetic ; alpha 1-Antitrypsin/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Lab v. field: the case for studying real-life bugs (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-10-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):92-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364779" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Genetically Modified ; *Anopheles/genetics/parasitology/physiology ; Behavior, Animal ; Biological Evolution ; *Culicidae/genetics/parasitology/physiology ; Ecology ; Genetics, Population ; Genome ; Humans ; *Insect Vectors/genetics/parasitology/physiology ; Malaria/prevention & control/transmission ; Molecular Biology ; Mosquito Control ; Plasmodium/physiology ; *Research ; Research Support as Topic ; Sequence Analysis, DNA ; Sexual Behavior, Animal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Genomics. Gene duplication and evolution (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-08-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lynch, Michael -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):945-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Indiana University, Bloomington, IN 47405, USA. mlynch@bio.indiana.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169715" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Caenorhabditis elegans/genetics ; Chromosomes/genetics ; Chromosomes, Human/genetics ; *Gene Duplication ; Gene Rearrangement ; Gene Silencing ; *Genes, Duplicate ; *Genome, Human ; Genomics ; Humans ; Mutation ; Selection, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Visualization and functional analysis of RNA-dependent RNA polymerase lattices (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-06-22
    Beschreibung: Positive-strand RNA viruses such as poliovirus replicate their genomes on intracellular membranes of their eukaryotic hosts. Electron microscopy has revealed that purified poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays. The structural integrity of these arrays correlates with cooperative RNA binding and RNA elongation and is sensitive to mutations that disrupt intermolecular contacts predicted by the polymerase structure. Membranous vesicles isolated from poliovirus-infected cells contain structures consistent with the presence of two-dimensional polymerase arrays on their surfaces during infection. Therefore, host cytoplasmic membranes may function as physical foundations for two-dimensional polymerase arrays, conferring the advantages of surface catalysis to viral RNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyle, John M -- Bullitt, Esther -- Bienz, Kurt -- Kirkegaard, Karla -- AI-42119/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2218-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077417" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Binding Sites ; Catalysis ; Crystallography, X-Ray ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Inclusion Bodies, Viral/metabolism/ultrastructure ; Microscopy, Electron ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nucleic Acid Conformation ; Poliovirus/*enzymology/physiology ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; RNA Replicase/*chemistry/isolation & purification/*metabolism/ultrastructure ; RNA, Viral/biosynthesis/*metabolism ; Viral Core Proteins/metabolism ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 41
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    Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-07-13
    Beschreibung: Full-length poliovirus complementary DNA (cDNA) was synthesized by assembling oligonucleotides of plus and minus strand polarity. The synthetic poliovirus cDNA was transcribed by RNA polymerase into viral RNA, which translated and replicated in a cell-free extract, resulting in the de novo synthesis of infectious poliovirus. Experiments in tissue culture using neutralizing antibodies and CD155 receptor-specific antibodies and neurovirulence tests in CD155 transgenic mice confirmed that the synthetic virus had biochemical and pathogenic characteristics of poliovirus. Our results show that it is possible to synthesize an infectious agent by in vitro chemical-biochemical means solely by following instructions from a written sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cello, Jeronimo -- Paul, Aniko V -- Wimmer, Eckard -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):1016-8. Epub 2002 Jul 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12114528" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Capsid/metabolism ; Cell-Free System ; DNA, Complementary/*chemical synthesis/genetics ; DNA-Directed RNA Polymerases/genetics ; Female ; *Genome, Viral ; HeLa Cells ; Humans ; Male ; *Membrane Proteins ; Mice ; Mice, Transgenic ; Neutralization Tests ; Poliomyelitis/virology ; *Poliovirus/genetics/immunology/pathogenicity/physiology ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA, Viral/*chemical synthesis/genetics/physiology ; Receptors, Virus/genetics/immunology/metabolism ; Transcription, Genetic ; Viral Plaque Assay ; Viral Proteins ; Virulence ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 42
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    Planetary science. NASA's new road to faster, cheaper, better exploration (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-11-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1320-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434031" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; *Planets ; Research Personnel ; Research Support as Topic ; Solar System ; Space Flight/*economics/*organization & administration/trends ; Spacecraft ; United States ; United States National Aeronautics and Space ; Administration/*economics/*organization & administration/trends
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 43
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    Stem cells. Setting standards for human embryonic stem cells (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brivanlou, Ali H -- Gage, Fred H -- Jaenisch, Rudolf -- Jessell, Thomas -- Melton, Douglas -- Rossant, Janet -- New York, N.Y. -- Science. 2003 May 9;300(5621):913-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rockefeller University, New York, NY 10021, USA. brvnlou@rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12738841" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Specimen Banks ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Division ; *Cell Line ; Culture Media ; Culture Media, Conditioned ; Databases, Factual ; *Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; Quality Control ; Registries ; Research/standards ; Signal Transduction ; Stem Cell Transplantation ; *Stem Cells/cytology/physiology ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 44
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    Construction and analysis of a human-chimpanzee comparative clone map (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-05
    Beschreibung: The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fujiyama, Asao -- Watanabe, Hidemi -- Toyoda, Atsushi -- Taylor, Todd D -- Itoh, Takehiko -- Tsai, Shih-Feng -- Park, Hong-Seog -- Yaspo, Marie-Laure -- Lehrach, Hans -- Chen, Zhu -- Fu, Gang -- Saitou, Naruya -- Osoegawa, Kazutoyo -- de Jong, Pieter J -- Suto, Yumiko -- Hattori, Masahira -- Sakaki, Yoshiyuki -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):131-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. afujiyam@gsc.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778049" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Chromosomes, Artificial, Bacterial ; Chromosomes, Human, Pair 21/genetics ; Cloning, Molecular ; Contig Mapping ; Female ; Gene Library ; *Genome ; *Genome, Human ; Humans ; Male ; Pan troglodytes/*genetics ; *Physical Chromosome Mapping ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Tagged Sites ; X Chromosome/genetics ; Y Chromosome/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 45
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    Disrupted timing of discontinuous but not continuous movements by cerebellar lesions (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-31
    Beschreibung: Patients with cerebellar damage are known to exhibit deficits in the temporal control of movements. We report that these deficits are restricted to discontinuous movements. Cerebellar patients exhibited no deficit in temporal variability when producing continuous, rhythmic movements. We hypothesize that the temporal properties of continuous movements are emergent and reflect the operation of other control parameters not associated with the cerebellum. In contrast, discontinuous movements require an explicit representation of the temporal goal, a function of the cerebellum. The requirement for explicit temporal representation provides a parsimonious account of cerebellar involvement in a range of tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spencer, Rebecca M C -- Zelaznik, Howard N -- Diedrichsen, Jorn -- Ivry, Richard B -- NS17778/NS/NINDS NIH HHS/ -- NS30256/NS/NINDS NIH HHS/ -- NS40813/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 May 30;300(5624):1437-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA 94720, USA. rspencer@socrates.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775842" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Aged, 80 and over ; Cerebellar Diseases/*physiopathology ; Cerebellum/physiology/*physiopathology ; Female ; Humans ; Male ; Middle Aged ; *Motor Activity ; Movement ; *Psychomotor Performance ; Spinocerebellar Degenerations/*physiopathology ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    Altered peptide ligands and MS treatment (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-06-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conlon, Paul -- Steinman, Lawrence -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1801-2; author reply 1801-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12053936" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Clinical Trials as Topic ; Controlled Clinical Trials as Topic ; Double-Blind Method ; Humans ; Ligands ; Multicenter Studies as Topic ; Multiple Sclerosis/*drug therapy ; Peptide Fragments/*adverse effects/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 47
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    Obesity drug pipeline not so fat (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 48
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    Portraits of science. Logic, learning, and experimental medicine (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nutton, Vivian -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):800-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for the History of Medicine, University College London, Euston House, 24 Eversholt Street, London NW1 1AD, UK. v.nutton@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823624" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anatomy/history ; Anatomy, Comparative/history ; Animals ; Education, Medical/history ; History, Ancient ; Humans ; *Logic ; Philosophy, Medical/*history ; Physician's Role ; Research/*history ; Rome ; Turkey
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Ecology. Soil fertility and hunger in Africa (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sanchez, Pedro A -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2019-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International Center for Research in Agroforestry, Post Office Box 30677, Nairobi, Kenya. P.sanchez@cgiar.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896257" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa South of the Sahara ; Agriculture/*methods ; Biomass ; Crops, Agricultural/*growth & development ; *Ecosystem ; Fertilizers ; *Food Supply ; Forestry ; Humans ; Hunger ; Nitrogen ; Nitrogen Fixation ; Phosphates ; Plant Development ; Public Policy ; *Soil ; Trees/growth & development ; United Nations ; Zea mays/growth & development
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 50
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    Infectious disease. Another disease blights families in Siberia's far north (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):644.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976425" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; Humans ; Male ; Pedigree ; Siberia/epidemiology ; Spinocerebellar Ataxias/*epidemiology/*genetics ; *Trinucleotide Repeats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Inflammatory arthritis. How immune system gangs up on joints (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-09-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckman, Mary -- New York, N.Y. -- Science. 2002 Sep 6;297(5587):1626-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12215618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arthritis/*immunology ; Arthritis, Rheumatoid/immunology ; Autoantibodies/immunology ; Humans ; Joints/*immunology ; Mast Cells/immunology ; Mice
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Stromal effects on mammary gland development and breast cancer (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-11
    Beschreibung: Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here we review our present knowledge of the specific factors and cell types that contribute to epithelial-stromal crosstalk during mammary development. To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788989/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788989/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiseman, Bryony S -- Werb, Zena -- CA57621/CA/NCI NIH HHS/ -- R01 CA057621/CA/NCI NIH HHS/ -- R01 CA057621-07/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 May 10;296(5570):1046-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004111" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipocytes/cytology/physiology ; Animals ; Apoptosis ; Breast/cytology/embryology/*growth & development/physiology ; Breast Neoplasms/pathology/*physiopathology ; Cell Communication ; Epithelial Cells/physiology ; Extracellular Matrix/physiology ; Female ; Humans ; Mammary Glands, Animal/cytology/embryology/*growth & development/physiology ; Mammary Neoplasms, Animal/pathology/*physiopathology ; Morphogenesis ; Neoplasm Metastasis ; Pregnancy ; Signal Transduction ; Stromal Cells/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
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    Infectious disease. A many-headed medusa (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):643.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976424" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acute Disease ; Brain/*pathology ; Chronic Disease ; Encephalomyelitis/*pathology/*physiopathology ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 54
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    Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs) (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-10-04
    Beschreibung: Analysis of the human and mouse genomes identified an abundance of conserved non-genic sequences (CNGs). The significance and evolutionary depth of their conservation remain unanswered. We have quantified levels and patterns of conservation of 191 CNGs of human chromosome 21 in 14 mammalian species. We found that CNGs are significantly more conserved than protein-coding genes and noncoding RNAS (ncRNAs) within the mammalian class from primates to monotremes to marsupials. The pattern of substitutions in CNGs differed from that seen in protein-coding and ncRNA genes and resembled that of protein-binding regions. About 0.3% to 1% of the human genome corresponds to a previously unknown class of extremely constrained CNGs shared among mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermitzakis, Emmanouil T -- Reymond, Alexandre -- Scamuffa, Nathalie -- Ucla, Catherine -- Kirkness, Ewen -- Rossier, Colette -- Antonarakis, Stylianos E -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):1033-5. Epub 2003 Oct 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Medical Genetics and National Center of Competence in Research (NCCR) Frontiers in Genetics, University of Geneva Medical School and University Hospitals, 1211 Geneva, Switzerland. Emmanouil.Dermitzakis@medecine.unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14526086" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Chromosomes, Human, Pair 21/*genetics ; Chromosomes, Mammalian/*genetics ; *Conserved Sequence ; DNA, Intergenic/*genetics ; Discriminant Analysis ; *Evolution, Molecular ; Female ; Genetic Code ; Genome ; Humans ; Male ; Mammals/*genetics ; Molecular Sequence Data ; Polymerase Chain Reaction ; Proteins/genetics ; RNA, Untranslated/genetics ; Selection, Genetic ; Sequence Alignment ; Species Specificity ; Time ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 55
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    Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-02-09
    Beschreibung: The protein-protein interaction between leukocyte functional antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) is critical to lymphocyte and immune system function. Here, we report on the transfer of the contiguous, nonlinear epitope of ICAM-1, responsible for its association with LFA-1, to a small-molecule framework. These LFA-1 antagonists bound LFA-1, blocked binding of ICAM-1, and inhibited a mixed lymphocyte reaction (MLR) with potency significantly greater than that of cyclosporine A. Furthermore, in comparison to an antibody to LFA-1, they exhibited significant anti-inflammatory effects in vivo. These results demonstrate the utility of small-molecule mimics of nonlinear protein epitopes and the protein epitopes themselves as leads in the identification of novel pharmaceutical agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gadek, T R -- Burdick, D J -- McDowell, R S -- Stanley, M S -- Marsters, J C Jr -- Paris, K J -- Oare, D A -- Reynolds, M E -- Ladner, C -- Zioncheck, K A -- Lee, W P -- Gribling, P -- Dennis, M S -- Skelton, N J -- Tumas, D B -- Clark, K R -- Keating, S M -- Beresini, M H -- Tilley, J W -- Presta, L G -- Bodary, S C -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1086-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bioorganic Chemistry, Genentech, One DNA Way, South San Francisco, CA 94080, USA. trg@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834839" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical ; synthesis/chemistry/metabolism/pharmacology ; Cyclosporine/pharmacology ; Dermatitis, Irritant/drug therapy ; Dinitrofluorobenzene ; Drug Design ; Enzyme-Linked Immunosorbent Assay ; Epitopes ; Female ; Humans ; Immunoglobulin Fab Fragments/immunology/pharmacology ; Immunosuppressive Agents/chemical synthesis/chemistry/metabolism/*pharmacology ; Intercellular Adhesion Molecule-1/chemistry/*immunology/*metabolism ; Lymphocyte Culture Test, Mixed ; Lymphocyte Function-Associated Antigen-1/immunology/*metabolism ; Mice ; Mice, Inbred BALB C ; Molecular Mimicry ; Mutagenesis ; Protein Structure, Secondary ; Structure-Activity Relationship ; Thiophenes/*chemical synthesis/chemistry/metabolism/*pharmacology ; beta-Alanine/analogs & derivatives/*chemical ; synthesis/chemistry/metabolism/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 56
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    Infectious disease. Siberia's deadly stalker emerges from the shadows (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):642-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976423" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Antibodies, Viral/analysis ; Cerebral Cortex/pathology ; Cerebrospinal Fluid/virology ; Disease Outbreaks ; Encephalitis, Herpes Simplex/epidemiology ; Encephalomyelitis/ethnology/*etiology/pathology/virology ; Female ; Genetic Predisposition to Disease ; Herpesviridae/immunology/isolation & purification ; Herpesviridae Infections/ethnology/pathology/virology ; Humans ; Male ; Population Surveillance ; Rural Health ; Siberia/epidemiology ; Virus Diseases/ethnology/pathology/virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 57
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    Genetics. Toward a new vocabulary of human genetic variation (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-11-16
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271140/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271140/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sankar, Pamela -- Cho, Mildred K -- R01 HG002189/HG/NHGRI NIH HHS/ -- R01 HG002189-01/HG/NHGRI NIH HHS/ -- R01 HG002189-02/HG/NHGRI NIH HHS/ -- R01 HGO 2189-02/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1337-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Bioethics, University of Pennsylvania, Philadelphia, PA 19104-3308, USA. sankarp@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434037" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Continental Population Groups/*genetics ; Ethnic Groups/genetics ; Genetic Markers ; *Genetic Variation ; *Genetics, Medical ; Humans ; Terminology as Topic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 58
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    Genetics. FDA races in wrong direction (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-07-26
    Beschreibung: Despite recent genetic evidence and the promise of individualized medicine, there is a continuing interest in using self-identified categories of race and ethnicity as variables in scientific and medical research. The U.S. Food and Drug Administration recently proposed a standardized approach for the collection of race and ethnicity data in clinical trials. We believe that this move fails to acknowledge new scientific data and recommend that relevant data from individuals be collected and used rather than broad group statistics. We also encourage that increased funding be committed to this important issue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haga, Susanne B -- Venter, J Craig -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):466.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Advancement of Genomics, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881555" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Clinical Trials as Topic ; *Continental Population Groups/genetics ; *Ethnic Groups/genetics ; Gene Frequency ; Genetic Variation ; Guidelines as Topic ; Humans ; Pharmacogenetics ; United States ; *United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 59
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    Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-19
    Beschreibung: Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Abeta peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kayed, Rakez -- Head, Elizabeth -- Thompson, Jennifer L -- McIntire, Theresa M -- Milton, Saskia C -- Cotman, Carl W -- Glabe, Charles G -- AG00538/AG/NIA NIH HHS/ -- AG16573/AG/NIA NIH HHS/ -- NS31230/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 18;300(5618):486-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702875" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism/pathology ; Amyloid/chemistry/toxicity ; Amyloid beta-Peptides/analysis/*chemistry/immunology/toxicity ; Animals ; Antibodies/immunology ; Antibody Specificity ; Biopolymers/analysis/chemistry/toxicity ; Brain/pathology ; Brain Chemistry ; Cell Survival ; Humans ; Microscopy, Confocal ; Microscopy, Electron ; Molecular Mimicry ; Neurofibrillary Tangles/chemistry ; Peptide Fragments/chemistry/immunology ; Protein Conformation ; Rabbits ; Solubility ; Tumor Cells, Cultured
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 60
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    Recent segmental duplications in the human genome (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-08-10
    Beschreibung: Primate-specific segmental duplications are considered important in human disease and evolution. The inability to distinguish between allelic and duplication sequence overlap has hampered their characterization as well as assembly and annotation of our genome. We developed a method whereby each public sequence is analyzed at the clone level for overrepresentation within a whole-genome shotgun sequence. This test has the ability to detect duplications larger than 15 kilobases irrespective of copy number, location, or high sequence similarity. We mapped 169 large regions flanked by highly similar duplications. Twenty-four of these hot spots of genomic instability have been associated with genetic disease. Our analysis indicates a highly nonrandom chromosomal and genic distribution of recent segmental duplications, with a likely role in expanding protein diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, Jeffrey A -- Gu, Zhiping -- Clark, Royden A -- Reinert, Knut -- Samonte, Rhea V -- Schwartz, Stuart -- Adams, Mark D -- Myers, Eugene W -- Li, Peter W -- Eichler, Evan E -- CA094816/CA/NCI NIH HHS/ -- GM58815/GM/NIGMS NIH HHS/ -- HG002318/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):1003-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Center for Computational Genomics, and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169732" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Base Sequence ; Biological Evolution ; Chromosomes, Human/genetics ; Computational Biology ; Databases, Nucleic Acid ; Exons ; Expressed Sequence Tags ; *Gene Duplication ; Gene Rearrangement ; *Genes, Duplicate ; Genetic Diseases, Inborn/genetics ; *Genome, Human ; Humans ; Models, Genetic ; Polymorphism, Single Nucleotide ; Proteome ; Recombination, Genetic ; Sequence Alignment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Adult-onset primary open-angle glaucoma caused by mutations in optineurin (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-02-09
    Beschreibung: Primary open-angle glaucoma (POAG) affects 33 million individuals worldwide and is a leading cause of blindness. In a study of 54 families with autosomal dominantly inherited adult-onset POAG, we identified the causative gene on chromosome 10p14 and designated it OPTN (for "optineurin"). Sequence alterations in OPTN were found in 16.7% of families with hereditary POAG, including individuals with normal intraocular pressure. The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in the tumor necrosis factor-alpha signaling pathway and that interacts with diverse proteins including Huntingtin, Ras-associated protein RAB8, and transcription factor IIIA. Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rezaie, Tayebeh -- Child, Anne -- Hitchings, Roger -- Brice, Glen -- Miller, Lauri -- Coca-Prados, Miguel -- Heon, Elise -- Krupin, Theodore -- Ritch, Robert -- Kreutzer, Donald -- Crick, R Pitts -- Sarfarazi, Mansoor -- EY-09947/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1077-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834836" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Alternative Splicing ; Amino Acid Sequence ; Brain/metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 10/genetics ; Ciliary Body/metabolism ; Exons ; Eye Proteins/analysis/chemistry/*genetics/physiology ; Female ; Glaucoma, Open-Angle/*genetics ; Golgi Apparatus/chemistry ; Heterozygote ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; *Mutation ; *Mutation, Missense ; Nerve Tissue Proteins/analysis/chemistry/*genetics/physiology ; Ocular Hypertension/genetics ; Pedigree ; Polymorphism, Single-Stranded Conformational ; Retina/metabolism ; Trabecular Meshwork/metabolism ; *Transcription Factor TFIIIA ; Zinc Fingers
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 62
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    Parkinson's disease. Coincidence or connection? (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):451-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964452" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Canada/epidemiology ; Cluster Analysis ; Environmental Exposure/adverse effects ; *Famous Persons ; Female ; History, 21st Century ; Humans ; Male ; Parkinson Disease/*epidemiology/etiology ; *Television ; Time Factors ; Virus Diseases/complications/epidemiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 63
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    Toxicology. Fruit bats linked to mystery disease (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):241.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951013" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amyotrophic Lateral Sclerosis/epidemiology/etiology ; Animals ; *Chiroptera ; *Cycas ; Cycasin/toxicity ; *Diet ; Guam/epidemiology ; Humans ; Neurodegenerative Diseases/epidemiology/*etiology ; Neurotoxins/toxicity ; Parkinsonian Disorders/epidemiology/etiology ; Plant Poisoning/epidemiology ; Plants, Toxic ; Seeds
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Historical essay. The early years of HIV/AIDS (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, Robert C -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1728-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459576" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Serodiagnosis/history ; Acquired Immunodeficiency Syndrome/diagnosis/*history/immunology/virology ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Cells, Cultured ; France ; *HIV/classification/isolation & purification/physiology ; History, 20th Century ; Human T-lymphotropic virus 1/isolation & purification/physiology ; Human T-lymphotropic virus 2/isolation & purification/physiology ; Humans ; Interleukin-2/history/isolation & purification/physiology ; Patents as Topic/history ; RNA-Directed DNA Polymerase/history/isolation & purification/metabolism ; United States ; Virus Cultivation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 65
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    Longevity research. In vino vitalis? Compounds activate life-extending genes (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, Stephen S -- New York, N.Y. -- Science. 2003 Aug 29;301(5637):1165.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12947168" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging ; Animals ; Caloric Restriction ; *Flavonoids ; *Gene Expression Regulation ; Histone Deacetylases/*genetics/metabolism ; Humans ; *Longevity ; Phenols/metabolism ; Polymers/metabolism ; Polyphenols ; Saccharomyces cerevisiae/genetics/physiology ; Silent Information Regulator Proteins, Saccharomyces ; cerevisiae/*genetics/metabolism ; Sirtuin 1 ; Sirtuin 2 ; Sirtuins/*genetics/metabolism ; Stilbenes/*metabolism ; Vitis/chemistry ; *Wine
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    Historical essay. Prospects for the future (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, Robert C -- Montagnier, Luc -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1730-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459577" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/immunology/therapeutic use ; *Acquired Immunodeficiency Syndrome/drug therapy/prevention & ; control/transmission/virology ; Anti-HIV Agents/therapeutic use ; Biomedical Research ; Clinical Trials as Topic ; Developed Countries ; Developing Countries ; Drug Costs ; Female ; HIV/drug effects ; Health Services/economics ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; International Cooperation ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Research Support as Topic ; Technology Transfer ; United Nations
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 67
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    Lateralized cognitive processes and lateralized task control in the human brain (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-07-19
    Beschreibung: The principles underlying human hemispheric specialization are poorly understood. We used functional magnetic resonance imaging of letter and visuospatial decision tasks with identical word stimuli to address two unresolved problems. First, hemispheric specialization depended on the nature of the task rather than on the nature of the stimulus. Second, analysis of frontal candidate regions for cognitive control showed increased coupling between left anterior cingulate cortex (ACC) and left inferior frontal gyrus during letter decisions, whereas right ACC showed enhanced coupling with right parietal areas during visuospatial decisions. Cognitive control is thus localized in the same hemisphere as task execution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephan, Klaas E -- Marshall, John C -- Friston, Karl J -- Rowe, James B -- Ritzl, Afra -- Zilles, Karl -- Fink, Gereon R -- 077029/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):384-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medicine (IME), Research Centre Julich, 52425 Julich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869765" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/*physiology ; Brain Mapping ; *Cognition ; Functional Laterality ; Gyrus Cinguli/physiology ; Humans ; *Language ; Magnetic Resonance Imaging ; Male ; Parietal Lobe/physiology ; Prefrontal Cortex/physiology ; Space Perception ; Visual Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 68
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    Lupus: mysterious disease holds its secrets tight (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):689-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976440" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Antinuclear/immunology/metabolism ; Autoantibodies/immunology ; Autoantigens/immunology ; Chromosome Mapping ; Clinical Trials as Topic ; Disease Susceptibility ; Epstein-Barr Virus Infections/complications ; Female ; Genetic Predisposition to Disease ; Humans ; Immune System/physiopathology ; Immunotherapy ; Lupus Erythematosus, Systemic/*etiology/genetics/immunology/therapy ; Male ; Mental Processes ; *Ribonucleoproteins, Small Nuclear ; Risk Factors ; snRNP Core Proteins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    Genomics. Mmu 16--comparative genomic highlights (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-06-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Copeland, Neal G -- Jenkins, Nancy A -- O'Brien, Stephen J -- New York, N.Y. -- Science. 2002 May 31;296(5573):1617-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, 21702, USA. copeland@ncifcrf.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040165" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Composition ; Biological Evolution ; Chromosome Aberrations ; Chromosomes/*genetics ; Chromosomes, Human/genetics ; Computational Biology ; Conserved Sequence ; Evolution, Molecular ; Gene Duplication ; Gene Rearrangement ; Genes ; Genome ; *Genome, Human ; Genomics ; Humans ; Mice ; Mice, Inbred Strains/*genetics ; Multigene Family ; *Sequence Analysis, DNA ; Species Specificity ; Synteny
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Neuroscience. Power to the paralyzed (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, Ingrid -- New York, N.Y. -- Science. 2003 Jan 24;299(5606):497.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12543950" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amyotrophic Lateral Sclerosis/physiopathology/*rehabilitation ; Brain/*physiology ; *Communication Aids for Disabled ; *Computer Systems ; Electroencephalography ; Humans ; Software ; *User-Computer Interface
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    Immunotherapeutic approaches to Alzheimer's disease (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-01
    Beschreibung: Although neurodegenerative diseases such as Alzheimer's disease are not classically considered mediated by inflammation or the immune system, in some instances the immune system may play an important role in the degenerative process. Furthermore, it has become clear that the immune system itself may have beneficial effects in nervous system diseases considered neurodegenerative. Immunotherapeutic approaches designed to induce a humoral immune response have recently been developed for the treatment of Alzheimer's disease. These studies have led to human trials that resulted in both beneficial and adverse effects. In animal models, it has also been shown that immunotherapy designed to induce a cellular immune response may be of benefit in central nervous system injury, although T cells may have either a beneficial or detrimental effect depending on the type of T cell response induced. These areas provide a new avenue for exploring immune system-based therapy of neurodegenerative diseases and will be discussed here with a primary focus on Alzheimer's disease. We will also discuss how these approaches affect microglia activation, which plays a key role in therapy of such diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monsonego, Alon -- Weiner, Howard L -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):834-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. amonsonego@rics.bwh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593170" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*therapy ; Alzheimer Vaccines/adverse effects/*therapeutic use ; Amyloid beta-Peptides/*immunology/metabolism ; Animals ; Antibody Formation ; Antigen-Presenting Cells/immunology ; Central Nervous System/immunology ; Clinical Trials as Topic ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Immunization ; *Immunotherapy/adverse effects ; Lymphocyte Activation ; Microglia/immunology ; Nitric Oxide/metabolism ; T-Lymphocytes/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Aging and genome maintenance: lessons from the mouse? (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-01
    Beschreibung: Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasty, Paul -- Campisi, Judith -- Hoeijmakers, Jan -- van Steeg, Harry -- Vijg, Jan -- AG17242/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1355-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA. hastye@uthscsa.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610296" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging/genetics ; Aging, Premature/*genetics ; Animals ; Apoptosis ; Cell Aging ; *DNA Damage ; DNA Helicases/genetics/metabolism ; *DNA Repair/genetics ; Exodeoxyribonucleases ; *Genome ; Genome, Human ; Humans ; Longevity/genetics ; Mice ; Mutation ; Reactive Oxygen Species/metabolism ; RecQ Helicases ; Syndrome ; Telomere/physiology ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Comment on "Obesity and the environment: where do we go from here?" (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-08-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butte, Nancy F -- Ellis, Kenneth J -- New York, N.Y. -- Science. 2003 Aug 1;301(5633):598; author reply 598.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. nbutte@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12893926" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Body Mass Index ; Child ; Diet ; *Energy Intake ; *Energy Metabolism ; *Exercise ; Feeding Behavior ; Humans ; Life Style ; *Obesity/epidemiology/prevention & control ; United States/epidemiology ; *Weight Gain
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    AIDS and Africa: still a sad story (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2003 May 16;300(5622):1053.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12750481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*economics/epidemiology/prevention & ; control/transmission ; Africa/epidemiology ; Disease Outbreaks/economics ; Financing, Government ; Health Care Costs ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; South Africa/epidemiology ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-07-12
    Beschreibung: Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dumas, John J -- Kumar, Ravindra -- Seehra, Jasbir -- Somers, William S -- Mosyak, Lidia -- New York, N.Y. -- Science. 2003 Jul 11;301(5630):222-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Screening Sciences, Wyeth, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855811" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding Sites ; Blood Platelets/chemistry/physiology ; Crystallization ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Platelet Adhesiveness ; *Platelet Aggregation ; Platelet Glycoprotein GPIb-IX Complex/*chemistry/*metabolism ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thrombin/*chemistry/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Molecular pathways of neurodegeneration in Parkinson's disease (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-01
    Beschreibung: Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that neuroprotective agents may have broad applicability in the treatment of PD. Current evidence suggests that mitochondrial complex I inhibition may be the central cause of sporadic PD and that derangements in complex I cause alpha-synuclein aggregation, which contributes to the demise of dopamine neurons. Accumulation and aggregation of alpha-synuclein may further contribute to the death of dopamine neurons through impairments in protein handling and detoxification. Dysfunction of parkin (a ubiquitin E3 ligase) and DJ-1 could contribute to these deficits. Strategies aimed at restoring complex I activity, reducing oxidative stress and alpha-synuclein aggregation, and enhancing protein degradation may hold particular promise as powerful neuroprotective agents in the treatment of PD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dawson, Ted M -- Dawson, Valina L -- NS38377/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):819-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. tdawson@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593166" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Genetically Modified ; Brain/*metabolism/pathology ; Cysteine Endopeptidases/metabolism ; Dopamine/metabolism ; Electron Transport Complex I/antagonists & inhibitors/genetics/*metabolism ; Humans ; Mitochondria/enzymology ; Multienzyme Complexes/metabolism ; Mutation ; Nerve Degeneration ; Nerve Tissue Proteins/chemistry/genetics/metabolism ; Neurons/*metabolism/pathology ; Oxidative Stress ; Parkinson Disease/*etiology/genetics/metabolism/pathology ; Parkinsonian Disorders/genetics/metabolism/pathology ; Proteasome Endopeptidase Complex ; Synucleins ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics/metabolism ; alpha-Synuclein
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Chromosomal speciation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-08-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowers, Evelyn J -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):764-5; author reply 764-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907779" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chromosomes, Human/genetics ; Chromosomes, Human, Pair 2/genetics ; Chromosomes, Mammalian/*genetics ; Evolution, Molecular ; Genetics, Population ; Hominidae/*genetics ; Humans ; Pan troglodytes/*genetics ; *Recombination, Genetic ; *Selection, Genetic ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 78
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    Polyubiquitination of p53 by a ubiquitin ligase activity of p300 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-12
    Beschreibung: Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding protein transcriptional coactivator proteins. p53 is stabilized by the binding of p300 to the oncoprotein E1A, suggesting that p300 regulates p53 degradation. Purified p300 exhibited intrinsic ubiquitin ligase activity that was inhibited by E1A. In vitro, p300 with MDM2 catalyzed p53 polyubiquitination, whereas MDM2 catalyzed p53 monoubiquitination. E1A expression caused a decrease in polyubiquitinated but not monoubiquitinated p53 in cells. Thus, generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grossman, Steven R -- Deato, Maria E -- Brignone, Chrystelle -- Chan, Ho Man -- Kung, Andrew L -- Tagami, Hideaki -- Nakatani, Yoshihiro -- Livingston, David M -- CA15751/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690203" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenovirus E1A Proteins/metabolism ; Animals ; Catalysis ; Cells, Cultured ; E1A-Associated p300 Protein ; Embryo, Mammalian ; Fibroblasts/metabolism ; Humans ; Ligases/antagonists & inhibitors/metabolism ; Mice ; Nuclear Proteins/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-mdm2 ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/metabolism ; Trans-Activators/antagonists & inhibitors/*metabolism ; Transfection ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/*metabolism ; Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Calculating the benefits of regulation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roelofs, Cora R -- Ellenbecker, Michael J -- New York, N.Y. -- Science. 2003 May 30;300(5624):1372.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775824" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cost-Benefit Analysis ; Environmental Health ; *Government Regulation ; *Health ; Humans ; Safety ; United States ; *United States Occupational Safety and Health Administration ; *Value of Life
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Polymer replicas of photonic porous silicon for sensing and drug delivery applications (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-29
    Beschreibung: Elaborate one-dimensional photonic crystals are constructed from a variety of organic and biopolymers, which can be dissolved or melted, by templating the solution-cast or injection-molded materials in porous silicon or porous silicon dioxide multilayer (rugate dielectric mirror) structures. After the removal of the template by chemical dissolution, the polymer castings replicate the photonic features and the nanostructure of the master. We demonstrate that these castings can be used as vapor sensors, as deformable and tunable optical filters, and as self-reporting, bioresorbable materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Yang Yang -- Cunin, Frederique -- Link, Jamie R -- Gao, Ting -- Betts, Ronald E -- Reiver, Sarah H -- Chin, Vicki -- Bhatia, Sangeeta N -- Sailor, Michael J -- New York, N.Y. -- Science. 2003 Mar 28;299(5615):2045-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Department 0358, La Jolla, CA 92093-0358, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12663921" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biocompatible Materials ; Caffeine ; *Drug Delivery Systems ; Ethanol ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Light ; *Nanotechnology ; Optics and Photonics ; Oxidation-Reduction ; Polyesters/chemistry ; Polyethylene/chemistry ; *Polymers ; Polystyrenes/chemistry ; Porosity ; *Silicon/chemistry ; Silicon Dioxide/chemistry ; Spectrum Analysis ; Volatilization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 81
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    Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-26
    Beschreibung: The active-site cysteine of peroxiredoxins is selectively oxidized to cysteine sulfinic acid during catalysis, which leads to inactivation of peroxidase activity. This oxidation was thought to be irreversible. However, by metabolic labeling of mammalian cells with 35S, we show that the sulfinic form of peroxiredoxin I, produced during the exposure of cells to H2O2, is rapidly reduced to the catalytically active thiol form. The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woo, Hyun Ae -- Chae, Ho Zoon -- Hwang, Sung Chul -- Yang, Kap-Seok -- Kang, Sang Won -- Kim, Kanghwa -- Rhee, Sue Goo -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):653-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714748" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Catalysis ; Cell Line ; Cycloheximide/pharmacology ; Cysteine/*analogs & derivatives/*metabolism ; Dimerization ; HeLa Cells ; Humans ; Hydrogen Peroxide/*metabolism ; Methionine/metabolism ; Mice ; Neurotransmitter Agents ; Oxidation-Reduction ; Peroxidases/chemistry/*metabolism ; Peroxiredoxins ; Protein Synthesis Inhibitors/pharmacology ; Spectrometry, Mass, Electrospray Ionization ; Sulfhydryl Compounds/metabolism ; Sulfinic Acids/metabolism ; Tumor Cells, Cultured
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 82
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    Chromosomal instability and tumors promoted by DNA hypomethylation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eden, Amir -- Gaudet, Francois -- Waghmare, Alpana -- Jaenisch, Rudolf -- CA87869/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 18;300(5618):455.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702868" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chromosomes, Mammalian/*genetics/physiology ; DNA (Cytosine-5-)-Methyltransferase/genetics/metabolism ; *DNA Methylation ; Fibroblasts/metabolism ; Genes, Neurofibromatosis 1 ; Genes, p53 ; Humans ; *Loss of Heterozygosity ; Mice ; Mutation ; Neoplasms/genetics ; Recombination, Genetic ; Sarcoma/*genetics ; Soft Tissue Neoplasms/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 83
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    Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-06
    Beschreibung: We have used adenosine diphosphate analogs containing electron paramagnetic resonance (EPR) spin moieties and EPR spectroscopy to show that the nucleotide-binding site of kinesin-family motors closes when the motor.diphosphate complex binds to microtubules. Structural analyses demonstrate that a domain movement in the switch 1 region at the nucleotide site, homologous to domain movements in the switch 1 region in the G proteins [heterotrimeric guanine nucleotide-binding proteins], explains the EPR data. The switch movement primes the motor both for the free energy-yielding nucleotide hydrolysis reaction and for subsequent conformational changes that are crucial for the generation of force and directed motion along the microtubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naber, Nariman -- Minehardt, Todd J -- Rice, Sarah -- Chen, Xiaoru -- Grammer, Jean -- Matuska, Marija -- Vale, Ronald D -- Kollman, Peter A -- Car, Roberto -- Yount, Ralph G -- Cooke, Roger -- Pate, Edward -- AR39643/AR/NIAMS NIH HHS/ -- AR42895/AR/NIAMS NIH HHS/ -- DK05915/DK/NIDDK NIH HHS/ -- GM29072/GM/NIGMS NIH HHS/ -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2003 May 2;300(5620):798-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of California, San Francisco, CA 94143, USA. naber@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12730601" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenine Nucleotides/*metabolism ; Adenosine Diphosphate/analogs & derivatives/metabolism ; Adenosine Triphosphate/analogs & derivatives/metabolism ; Animals ; Binding Sites ; Computer Simulation ; Crystallography, X-Ray ; *Drosophila Proteins ; Drosophila melanogaster ; Electron Spin Resonance Spectroscopy ; Humans ; Hydrogen Bonding ; Hydrolysis ; Kinesin/*chemistry/*metabolism ; Microtubules/*metabolism ; Models, Molecular ; Molecular Motor Proteins/*chemistry/*metabolism ; Molecular Probes/metabolism ; Protein Conformation ; Spin Labels
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 84
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    Arctic ecology. For precarious populations, pollutants present new perils (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webster, Paul -- New York, N.Y. -- Science. 2003 Mar 14;299(5613):1642.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12637710" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arctic Regions ; Canada ; *Ecosystem ; Environmental Exposure/*adverse effects ; Environmental Pollutants/*analysis ; Female ; Humans ; Infant ; Infection/epidemiology/etiology ; *Inuits ; Memory ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    A heterozygote advantage (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-10-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedrick, Philip W -- New York, N.Y. -- Science. 2003 Oct 3;302(5642):57.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14526061" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Ethnic Groups/*genetics ; Female ; Genetic Variation ; Genotype ; Haplotypes ; *Heterozygote ; Humans ; Kuru/*genetics ; Male ; Middle Aged ; Papua New Guinea ; PrPC Proteins/*genetics ; *Selection, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 86
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    Structural dynamics of eukaryotic chromosome evolution (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-08-09
    Beschreibung: Large-scale genome sequencing is providing a comprehensive view of the complex evolutionary forces that have shaped the structure of eukaryotic chromosomes. Comparative sequence analyses reveal patterns of apparently random rearrangement interspersed with regions of extraordinarily rapid, localized genome evolution. Numerous subtle rearrangements near centromeres, telomeres, duplications, and interspersed repeats suggest hotspots for eukaryotic chromosome evolution. This localized chromosomal instability may play a role in rapidly evolving lineage-specific gene families and in fostering large-scale changes in gene order. Computational algorithms that take into account these dynamic forces along with traditional models of chromosomal rearrangement show promise for reconstructing the natural history of eukaryotic chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eichler, Evan E -- Sankoff, David -- GM58815/GM/NIGMS NIH HHS/ -- HD43569/HD/NICHD NIH HHS/ -- HG02385/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):793-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Center for Human Genetics and Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. eee@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907789" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Centromere/physiology ; Chromosome Aberrations ; *Chromosomes/genetics/physiology/ultrastructure ; Computational Biology ; DNA Transposable Elements ; Eukaryotic Cells/physiology/*ultrastructure ; Gene Duplication ; Genome ; Humans ; Recombination, Genetic ; Synteny ; Telomere/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 87
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    Infectious disease. An avian flu jumps to people (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wuethrich, Bernice -- New York, N.Y. -- Science. 2003 Mar 7;299(5612):1504.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12624244" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Birds/virology ; Chickens/virology ; Child ; China/epidemiology ; Hong Kong/epidemiology ; Humans ; Influenza A virus/genetics/immunology/*pathogenicity ; Influenza Vaccines ; Influenza in Birds/epidemiology/*virology ; Influenza, Human/*virology ; Male ; Virulence ; World Health Organization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    Comment on "On the origin of interictal activity in human temporal lobe epilepsy in vitro" (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-07-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wozny, Christian -- Kivi, Anatol -- Lehmann, Thomas-Nicolas -- Dehnicke, Christoph -- Heinemann, Uwe -- Behr, Joachim -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):463; author reply 463.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Research Center, at the Charite, Humboldt University of Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881553" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Electroencephalography ; Epilepsy, Temporal Lobe/pathology/*physiopathology ; Excitatory Amino Acid Antagonists ; Hippocampus/pathology/*physiopathology ; Humans ; In Vitro Techniques ; Neurons/physiology ; Neurons, Afferent/physiology ; Receptors, GABA-A/metabolism ; Receptors, Glutamate/metabolism ; Synaptic Transmission ; Temporal Lobe/physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    Tracking children's health to age 21 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, E Stephen -- Green, Nancy -- Henry, Carol J -- Landrigan, Philip J -- Swartz, Daniel -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):781.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593148" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Child ; *Child Development ; Costs and Cost Analysis ; *Disease ; *Epidemiologic Studies ; *Health ; Humans ; Social Environment ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 90
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    Genetics and medicine. Putting gene arrays to the test (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branca, Malorye -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):238.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690165" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Breast Neoplasms/*classification/*genetics/therapy ; Clinical Trials as Topic ; Female ; *Gene Expression Profiling ; Humans ; Netherlands ; *Oligonucleotide Array Sequence Analysis ; Prognosis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    In sickness or in health? (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Laura -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):808-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593163" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research ; Brain/pathology/physiopathology ; Child ; Clinical Trials as Topic ; Humans ; *Manuals as Topic ; Mental Disorders/*classification/*diagnosis/epidemiology/genetics ; *Mental Health ; Personality Disorders/classification/diagnosis/genetics ; Psychotropic Drugs/pharmacology/therapeutic use ; Risk Factors ; Social Environment ; Terminology as Topic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 92
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    Insulin staining of ES cell progeny from insulin uptake (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, Jayaraj -- Anderson, William J -- Kume, Shoen -- Martinez, Olga I -- Melton, Douglas A -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532008" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies/immunology ; Apoptosis ; Cell Differentiation ; Cell Line ; Embryo, Mammalian/*cytology ; Humans ; Insulin/*analysis/genetics/immunology/*metabolism ; Islets of Langerhans/*cytology/metabolism ; Mice ; Microscopy, Confocal ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stem Cells/*cytology/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 93
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    Lamin a truncation in Hutchinson-Gilford progeria (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Sandre-Giovannoli, Annachiara -- Bernard, Rafaelle -- Cau, Pierre -- Navarro, Claire -- Amiel, Jeanne -- Boccaccio, Irene -- Lyonnet, Stanislas -- Stewart, Colin L -- Munnich, Arnold -- Le Merrer, Martine -- Levy, Nicolas -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inserm U491: Genetique Medicale et Developpement, Faculte de Medecine Timone, Marseille, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702809" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Cell Nucleus/ultrastructure ; Child ; Exons ; Female ; Humans ; Lamin Type A/analysis/*chemistry/*genetics ; Lymphocytes/chemistry/ultrastructure ; Mutation ; Polymorphism, Genetic ; Progeria/blood/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Sequence Deletion ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 94
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    Global food security: challenges and policies (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-12-13
    Beschreibung: Global food security will remain a worldwide concern for the next 50 years and beyond. Recently, crop yield has fallen in many areas because of declining investments in research and infrastructure, as well as increasing water scarcity. Climate change and HIV/AIDS are also crucial factors affecting food security in many regions. Although agroecological approaches offer some promise for improving yields, food security in developing countries could be substantially improved by increased investment and policy reforms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosegrant, Mark W -- Cline, Sarah A -- New York, N.Y. -- Science. 2003 Dec 12;302(5652):1917-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International Food Policy Research Institute, 2033 K Street, N.W., Washington, DC 20006, USA. m.rosegrant@cgiar.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14671289" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/epidemiology ; *Agriculture ; Biotechnology ; Climate ; Conservation of Natural Resources ; Developing Countries ; Ecosystem ; Education ; *Food ; *Food Supply ; Global Health ; Humans ; Poverty ; *Public Policy ; Research ; Rural Population ; Water Supply
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Cognitive neuroscience. Fear and trembling in the amygdala (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Laura -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714719" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amygdala/*physiology ; *Attention ; Cerebral Cortex/physiology ; Emotions ; *Facial Expression ; *Fear ; Frontal Lobe/physiology ; Humans ; Magnetic Resonance Imaging ; Parietal Lobe/physiology ; Visual Cortex/physiology ; Visual Pathways
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
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    Public health. French Supreme Court ends tainted blood saga (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casassus, Barbara -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2019.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829758" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Serodiagnosis ; Blood/*virology ; Blood Donors ; Blood Transfusion ; Blood-Borne Pathogens ; Creutzfeldt-Jakob Syndrome/transmission ; Drug Contamination ; France ; *Hiv ; HIV Infections/*transmission ; Human Growth Hormone ; Humans ; *Jurisprudence
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
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    Revisiting nuclear power plant safety (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-01-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyman, Edwin S -- New York, N.Y. -- Science. 2003 Jan 10;299(5604):201-3; author reply 201-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12523360" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Neoplasms, Radiation-Induced/epidemiology/etiology ; Nuclear Energy ; Nuclear Reactors ; *Power Plants ; Radioactive Hazard Release ; *Safety ; Security Measures ; *Terrorism ; Thyroid Neoplasms/epidemiology/etiology ; Ukraine/epidemiology ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
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    The ironic politics of obesity (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestle, Marion -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):781.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574583" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Child ; *Diet ; *Food Industry ; Humans ; Marketing ; *Nutrition Policy ; Nutritional Physiological Phenomena ; *Obesity/epidemiology/prevention & control ; Politics ; United States ; *United States Department of Agriculture
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
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    Molecular imaging: looking at problems, seeing solutions (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-10-25
    Beschreibung: Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With continued improvements in instrumentation, identification of better imaging targets by genome-based approaches, and design of better imaging probes by innovative chemistry, these technologies promise to play increasingly important roles in disease diagnosis and therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herschman, Harvey R -- P50 CA88306/CA/NCI NIH HHS/ -- R01 CA84572/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 24;302(5645):605-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, David Geffen School of Medicine at the University of California, Los Angeles, 341 Boyer Hall, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA. hherschman@mednet.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14576425" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Diagnostic Imaging/instrumentation/methods/trends ; *Disease Models, Animal ; Gene Expression ; Gene Expression Profiling ; Genes, Reporter ; Genomics ; Humans ; *Molecular Probe Techniques/instrumentation/trends ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    Comprehensive identification of human bZIP interactions with coiled-coil arrays (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-06-14
    Beschreibung: In eukaryotes, the combinatorial association of sequence-specific DNA binding proteins is essential for transcription. We have used protein arrays to test 492 pairings of a nearly complete set of coiled-coil strands from human basic-region leucine zipper (bZIP) transcription factors. We find considerable partnering selectivity despite the bZIPs' homologous sequences. The interaction data are of high quality, as assessed by their reproducibility, reciprocity, and agreement with previous observations. Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newman, John R S -- Keating, Amy E -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2097-101. Epub 2003 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805554" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Basic-Leucine Zipper Transcription Factors ; Chromatography, High Pressure Liquid ; Circadian Rhythm ; Circular Dichroism ; Cyclic AMP Response Element-Binding Protein/chemistry/metabolism ; DNA-Binding Proteins/chemistry/isolation & purification/*metabolism ; Dimerization ; G-Box Binding Factors ; Humans ; *Leucine Zippers ; Peptides/chemistry/isolation & purification/metabolism ; *Protein Array Analysis ; Protein Binding ; Protein Folding ; Protein Structure, Tertiary ; Signal Transduction ; Temperature ; Thermodynamics ; Transcription Factors/*chemistry/isolation & purification/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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