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  • 1
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    Lateralized cognitive processes and lateralized task control in the human brain (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-07-19
    Description: The principles underlying human hemispheric specialization are poorly understood. We used functional magnetic resonance imaging of letter and visuospatial decision tasks with identical word stimuli to address two unresolved problems. First, hemispheric specialization depended on the nature of the task rather than on the nature of the stimulus. Second, analysis of frontal candidate regions for cognitive control showed increased coupling between left anterior cingulate cortex (ACC) and left inferior frontal gyrus during letter decisions, whereas right ACC showed enhanced coupling with right parietal areas during visuospatial decisions. Cognitive control is thus localized in the same hemisphere as task execution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephan, Klaas E -- Marshall, John C -- Friston, Karl J -- Rowe, James B -- Ritzl, Afra -- Zilles, Karl -- Fink, Gereon R -- 077029/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):384-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medicine (IME), Research Centre Julich, 52425 Julich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869765" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*physiology ; Brain Mapping ; *Cognition ; Functional Laterality ; Gyrus Cinguli/physiology ; Humans ; *Language ; Magnetic Resonance Imaging ; Male ; Parietal Lobe/physiology ; Prefrontal Cortex/physiology ; Space Perception ; Visual Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    BigBrain: an ultrahigh-resolution 3D human brain model (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-22
    Description: Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amunts, Katrin -- Lepage, Claude -- Borgeat, Louis -- Mohlberg, Hartmut -- Dickscheid, Timo -- Rousseau, Marc-Etienne -- Bludau, Sebastian -- Bazin, Pierre-Louis -- Lewis, Lindsay B -- Oros-Peusquens, Ana-Maria -- Shah, Nadim J -- Lippert, Thomas -- Zilles, Karl -- Evans, Alan C -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1472-5. doi: 10.1126/science.1235381.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience and Medicine (INM-1, INM-4), Research Centre Julich, Julich, Germany. k.amunts@fz-juelich.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23788795" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*anatomy & histology/*cytology ; *Brain Mapping ; Cerebral Cortex/anatomy & histology/cytology ; Female ; Humans ; Image Processing, Computer-Assisted ; *Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Microtomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Neuroscience. Segregation and wiring in the brain (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zilles, Karl -- Amunts, Katrin -- New York, N.Y. -- Science. 2012 Mar 30;335(6076):1582-4. doi: 10.1126/science.1221366.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Dusseldorf, Dusseldorf, Germany. k.zilles@fz-juelich.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22461598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*anatomy & histology/*metabolism ; *Genes ; Humans ; Male ; *Nerve Fibers ; Neural Pathways/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental studies of rubidium absolute polarization at high temperatures (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 75 (1999), S. 427-429 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report on measurements of the absolute rubidium (Rb) polarization, optically pumped by a high-power diode laser array, up to temperatures of 180 °C. The penetration of the pump laser light into a high-pressure cell has been studied experimentally and theoretically. The experimental results are compared to a model, which describes the local Rb polarization and optical pumping rate in the cell. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.124397
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  • 5
    Electronic Resource
    Electronic Resource
    Cortical folding, the lunate sulcus and the evolution of the human brain
    Amsterdam : Elsevier
    Journal of Human Evolution 20 (1991), S. 341-348 
    Details
    ISSN: 0047-2484
    Keywords: australopithecines ; convolutions ; cortex ; evolution ; sulci
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0047-2484(91)90014-M
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  • 6
    Electronic Resource
    Electronic Resource
    Cortical folding and the evolution of the human brain
    Amsterdam : Elsevier
    Journal of Human Evolution 25 (1993), S. 387-392 
    Details
    ISSN: 0047-2484
    Keywords: cortex, human evolution, development, sulci, australopithecines
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/jhev.1993.1057
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative immunohistochemical analysis of VIP-neurons in the rat visual cortex (1988)
    Springer
    Histochemistry and cell biology 90 (1988), S. 139-144 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A critical appraisal of quantitative immunohistochemistry of neuropeptides in presented defining the main criteria of selecting the type of immune-staining and preparation suitable for these investigations. As an example of meeting the established criteria, the immunohistochemical demonstration of vasoactive intestinal polypeptide (VIP)-containing neurons in the rat brain and the processing of VIP-immunostained preparations for computer-controlled image analyis are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500978
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  • 8
    Electronic Resource
    Electronic Resource
    Local cerebral glucose utilization in the autoimmune New Zealand Black (NZB) mouse (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 343-348 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By means of the [14C]-2-deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in 41 brain regions in autoimmune New Zealand Black (NZB) mice and in Carworth Farm Winkelmann (CFW) mice, which served as the control strain. At the age of 6 months, the mean LCGU of all measured areas and brain stem nuclei was 67.7 μmol glucose/(100 g x min) in the nonautoimmune CFW mice. These LCGU values are within the limits published by other observers. In contrast, in the aged-matched NZB mice the glucose use was markedly reduced, the mean LCGU of all measured areas being 37.7 μmol glucose/(100 g x min). These findings suggest that the immunological, morphological and behavioural abnormalities in the aged NZB mouse correlate with a reduced functional activity of the central nervous system, measured as reduced cerebral glucose utilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500551
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  • 9
    Electronic Resource
    Electronic Resource
    Quantitative receptor autoradiography in the human brain (1988)
    Springer
    Histochemistry and cell biology 90 (1988), S. 129-137 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Quantitative receptor autoradiography on sections of the human brain raises methodical problems of which some are relevant also for studies in animal tissue, but others are unique in studies of human brain tissue. Procedures for the following methodical aspects are discussed image analysis for quantitation of the regional distribution of receptor densities, saturation analysis on autoradiographs, influence of age and post-mortem delay and quenching of β-radiation in brain tissue. The solutions proposed to these problems make receptor autoradiography in the human brain to a reliable method for studies of chemical neuroanatomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500977
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  • 10
    Electronic Resource
    Electronic Resource
    A new method for quenching correction leads to revisions of data in receptor autoradiography (1990)
    Springer
    Histochemistry and cell biology 94 (1990), S. 569-578 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Differential quenching of β-emission affects strongly the analysis of receptor distribution patterns in quantitative receptor autoradiography with tritiated ligands. Different methods for the quenching correction have been described in the past, but some of these are of limited value, if a detailed anatomical parcellation is necessary. Other methods correct exclusively local variations in lipid concentration, which is an important, but only one of several factors causing quenching. A new method for the measurement of quenching (or autoradiographic efficiency) is presented, which permits an anatomically detailed and direct determination of the total quenching without lipid extraction procedures. This method is based on the measurement of autoradiographic efficiency in cryostat sections homogeneously labeled with tritiated formaldehyde by an underlying gelatine section containing this labeled compound. Regional and layer specific measurements of autoradiographic efficiency in cortical and subcortical regions of the human and rat brain are reported. A significant correlation was found between the density of myelin and autoradiographic efficiency but other factors were also shown to influence differential quenching. The use of the here presented correction procedure leads to revisions of the laminar distribution patterns reported for different receptors in human and rat cortical areas. Our results show, that a complete quenching correction is necessary for the mapping of receptor distributions with tritiated ligands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271983
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