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  • 1983  (662)
  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-11
    Description: When injected into mice, the synthetic double-stranded polynucleotide poly(inosinic) X poly(cytidylic) acid induces high natural killer (NK) cell activity within 4 to 12 hours. Induction of NK activity in mice immunized 2 or 3 days previously, or the addition of NK cells to cultures immunized in vitro 2 or 3 days previously, promotes early termination of the ongoing primary immunoglobulin M antibody response. A target for NK cells is a population of accessory cells that has interacted with antigen and is necessary for sustaining the antibody response. The inference is strong that NK cells induced normally by immunization also terminate the usual antibody response in vivo by elimination of antigen-exposed accessory cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abruzzo, L V -- Rowley, D A -- 5-T32-CA-09267/CA/NCI NIH HHS/ -- R01-10242/PHS HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):581-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6685343" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Formation ; Antibody-Producing Cells/immunology ; Cells, Cultured ; Homeostasis ; Killer Cells, Natural/*immunology/radiation effects ; Lymphocyte Cooperation ; Lymphocytes/*immunology ; Mice ; Poly I-C/immunology ; Spleen/immunology
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: Information is represented in long-term memory as a network of associations among concepts. Information is retrieved by spreading activation from concepts in working memory through the network structure. The time required to retrieve information is a function of the level of activation that it achieves. Fanning of multiple paths from a node dissipates the activation the node sends down any path and increases retrieval time. Fan effects are reduced as subjects overlearn the material or when they can change their task from a recognition judgment to a consistency judgment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):25-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828877" target="_blank"〉PubMed〈/a〉
    Keywords: Face ; Humans ; *Memory ; Mental Recall ; Pattern Recognition, Visual
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-15
    Description: The neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) is present in the nerve terminals of an identified slow skeletal motoneuron in the cockroach. Proctolin is released onto the target muscle, a coxal depressor, by neuron stimulation and by depolarization with potassium. The physiological action of the motoneuron suggests that proctolin acts as a cotransmitter. Proctolin and neural stimulation produce delayed and sustained contractile effects without muscle depolarization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adams, M E -- O'Shea, M -- NS-16298/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):286-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6134339" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cockroaches ; Muscle Contraction ; Nerve Endings/physiology ; Neuromuscular Junction/*physiology ; *Neuropeptides ; Neurotransmitter Agents/*physiology ; Oligopeptides/*physiology ; Synaptic Transmission
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrew, R D -- Dudek, F E -- NS 16877/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879204" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Electrophysiology ; Evoked Potentials ; Feedback ; Hypothalamus/cytology ; In Vitro Techniques ; Membrane Potentials ; Neurosecretory Systems/cytology/*physiology ; Rats ; Tetrodotoxin/pharmacology
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-13
    Description: The existence of low-level filtering of sensory input is a point of debate among cognitive theorists. This present study suggests that filtering by modality exists at levels low enough to modulate the brainstem blink reflex and that it is evident as early as the 16th week of life. During foreground listening or looking conditions, blinks elicited by acoustic or visual probes were larger when probe and foreground modality matched than when they mismatched. "Interesting" foregrounds, by comparison with "dull" ones, intensified the modality-selective effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anthony, B J -- Graham, F K -- HDO1490/HD/NICHD NIH HHS/ -- K3-MH21762/MH/NIMH NIH HHS/ -- MHO1798/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):742-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836312" target="_blank"〉PubMed〈/a〉
    Keywords: Attention/*physiology ; Blinking ; Child Development ; Electromyography ; Hearing/physiology ; Heart Rate ; Humans ; Infant ; *Psychology, Child ; Vision, Ocular/physiology
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The morphological basis of the persistent synaptic plasticity that underlies long-term habituation and sensitization of the gill withdrawal reflex in Aplysia californica was explored by examining the fine structure of sensory neuron presynaptic terminals (the critical site of plasticity for the short-term forms of both types of learning) in control animals and in animals whose behavior had been modified by training. The number, size, and vesicle complement of sensory neuron active zones were larger in animals showing long-term sensitization than in control animals and smaller in animals showing long-term habituation. These changes are likely to represent an anatomical substrate for the memory consolidation of these tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, C H -- Chen, M -- GM23540/GM/NIGMS NIH HHS/ -- MH37134-01/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):91-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/*physiology ; Gills/innervation ; Habituation, Psychophysiologic/*physiology ; Neuronal Plasticity ; Neurons, Afferent/physiology ; Reflex/physiology ; Synapses/ultrastructure ; Synaptic Vesicles/physiology
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: Blink-startle responses to vibroacoustic stimulation were monitored ultrasonically in human fetuses of known gestational age. Responses were first elicited between 24 and 25 weeks of gestational age and were present consistently after 28 weeks. Defining the developmental sequence for audition provides a foundation for diagnosing deafness and recognizing aberrant responses antenatally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnholz, J C -- Benacerraf, B R -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623091" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Ear/*embryology ; Female ; Fetus/*physiology ; Gestational Age ; *Hearing ; Humans ; Pregnancy ; Ultrasonography ; Vibration
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  • 9
    Publication Date: 1983-04-15
    Description: Spirochetes believed to be the cause of Lyme disease were isolated from white-footed mice and white-tailed deer, the preferred natural hosts of Ixodes dammini, the tick vector. Evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. Some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosler, E M -- Coleman, J L -- Benach, J L -- Massey, D A -- Hanrahan, J P -- Burgdorfer, W -- Barbour, A G -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachnid Vectors/microbiology ; Arthritis, Infectious/microbiology/transmission ; Deer/microbiology/parasitology ; Disease Vectors ; Female ; Humans ; Male ; Peromyscus/microbiology/parasitology ; Spirochaetales/*growth & development ; Ticks/*microbiology
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-25
    Description: The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bengtsson, M -- Rydstrom, J -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Epoxide Hydrolases/metabolism ; *Estrus ; Female ; Glutathione Transferase/metabolism ; Gonadotropins, Equine/*pharmacology ; Metestrus ; Ovary/*physiology ; Pregnancy ; Proestrus ; Quinone Reductases/metabolism ; Rats ; Rats, Inbred Strains
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 16;222(4629):1251-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Flupenthixol/*pharmacology ; Hypothalamus/*drug effects ; Kinetics ; Rats ; *Reward ; Self Stimulation/*drug effects ; Thioxanthenes/*pharmacology
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 9;222(4628):1072-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648522" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Costs and Cost Analysis ; Humans ; Neoplasms/*prevention & control
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Sep 23;221(4617):1244-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6684327" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ethanol/*adverse effects ; Female ; Pregnancy ; Pregnancy, Animal/*drug effects
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Oct 14;222(4620):118-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623060" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Multiple Myeloma/*etiology ; Neoplasms, Radiation-Induced/*etiology ; Nuclear Warfare ; *Veterans Disability Claims
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉HD-12572/HD/NICHD NIH HHS/ -- MH-00318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):74-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623059" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Child, Preschool ; *Eye Movements ; Humans ; Research Design
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Apr 8;220(4593):142, 144, 146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828887" target="_blank"〉PubMed〈/a〉
    Keywords: Dental Caries/*prevention & control ; *Fluoridation ; Humans ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ames, B N -- ES01896/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1256-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6351251" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; *Carcinogens/antagonists & inhibitors ; Cocarcinogenesis ; Diet/*adverse effects ; Dietary Fats/adverse effects ; Free Radicals ; Hot Temperature ; Humans ; Lipid Peroxides/adverse effects ; Mutagens ; Oxygen/*toxicity ; Plants, Edible ; Smoking
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  • 18
    Publication Date: 1983-04-29
    Description: Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary in this unique form of radiation injury because inherent optical and thermal properties provide target selectivity. A simple, predictive model is presented. Selective damage to cutaneous microvessels and to melanosomes within melanocytes is shown after 577-nanometer (3 x 10(-7) second) and 351-nanometer (2 x 10(-8) second) pulses, respectively. Hemodynamic, histological, and ultrastructural responses are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, R R -- Parrish, J A -- R01025395/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Hot Temperature ; Humans ; *Laser Therapy ; Melanins/metabolism ; Melanocytes/ultrastructure ; Microcirculation/surgery ; Microscopy, Electron ; Microsurgery/*methods
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-27
    Description: Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antoniades, H N -- Hunkapiller, M W -- CA30101/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):963-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844921" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Electrophoresis, Polyacrylamide Gel ; Growth Substances/genetics/*metabolism ; Humans ; Molecular Weight ; Peptides/genetics/*metabolism ; Platelet-Derived Growth Factor
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The exposure of the population of Utah to external gamma-radiation from the fallout from nuclear weapons tests carried out between 1951 and 1958 at the Nevada Test Site has been reconstructed from recent measurements of residual cesium-137 and plutonium in soil. Although the highest exposures were found in the extreme southwest part of Utah, as expected, the residents of the populous northern valleys around Provo, Salt Lake City, and Ogden received a higher mean dose and a significantly greater population dose (person-rads) than did the residents of most counties closer to the test site. However, population doses from external exposure throughout Utah were far too low to result in any statistically observable health effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, H L -- Krey, P W -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828876" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Gamma Rays ; Humans ; Leukemia/etiology ; Nevada ; *Nuclear Warfare ; *Radiation ; Radiation Dosage ; Utah
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  • 21
    Publication Date: 1983-02-18
    Description: Cholesterol-loaded macrophages secrete cholesterol and apolipoprotein E. The current studies show that this secretion occurs by two independent pathways. In the absence of serum, the cells secrete apolipoprotein E, but not cholesterol. In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E. After secretion, apolipoprotein E and cholesterol associate with high-density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor-mediated endocytosis. We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in "reverse cholesterol transport."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basu, S K -- Goldstein, J L -- Brown, M S -- HL 20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823554" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apolipoproteins/*secretion ; Cholesterol/*secretion ; Lipoproteins, HDL/metabolism ; Macrophages/*metabolism ; Mice ; Monensin/pharmacology
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  • 22
    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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  • 23
    Publication Date: 1983-04-29
    Description: Selective pharmacological inhibition of thromboxane A2 synthesis did not prevent arachidonate-induced aggregation of human platelets in vitro. Prevention was instead achieved by a combination of thromboxane A2 inhibitors with low concentrations of aspirin. The latter partially reduced the proaggregatory cyclooxygenase products that accumulated when thromboxane A2 synthesis was blocked. The aspirin concentrations did not affect per se either platelet aggregation or prostacyclin synthesis in cultured human endothelial cells. The combination of thromboxane synthetase inhibitors with low doses of aspirin may offer greater antithrombotic potential than either drug alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertele, V -- Falanga, A -- Tomasiak, M -- Dejana, E -- Cerletti, C -- de Gaetano, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682245" target="_blank"〉PubMed〈/a〉
    Keywords: Aspirin/*pharmacology ; Blood Platelets/*drug effects/enzymology ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Imidazoles/pharmacology ; Methacrylates/pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Platelet Aggregation/drug effects ; Thromboxane-A Synthase/*antagonists & inhibitors
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  • 24
    Publication Date: 1983-02-25
    Description: A genetic recombinant within the major histocompatibility (B) complex of the chicken has revealed the chromosomal subregion effecting resistance to Marek's disease--a malignant lymphoma induced by a herpesvirus. The recombinant, BF21-G19, occurred spontaneously among the progeny of a male heterozygous for resistant BF21-G21 and susceptible BF19-G19 haplotypes. Exposure to Marek's disease of families segregating for the recombinant showed that this new F-G arrangement conferred a level of resistance equivalent to that of the resistant parental haplotype. Thus, a gene, or genes, within or closely linked to the B-F region of the B complex appears to be responsible for the observed resistance to Marek's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Briles, W E -- Briles, R W -- Taffs, R E -- Stone, H A -- CA12796/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):977-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823560" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chickens ; Chromosome Mapping ; Lymphoma/genetics/*immunology ; *Major Histocompatibility Complex ; Marek Disease/genetics/*immunology
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Monkeys in which nerves innervating the flexor muscles of the forearm and hand (the ulnar or the median nerve) had been surgically cross-united with the nerve innervating the extensor muscles (the radial nerve), and vice versa, showed excellent (ulnar-radial crosses) to moderate (median-radial crosses) control of movement performance after regeneration. Antagonistic movement responses were seen occasionally, but these were corrected almost immediately. Stimulation of the crossed nerves showed that they had innervated the antagonistic muscle groups. The results reveal the capacity of the primate central nervous system to adapt to gross disturbances imposed on the execution of movements by changes in peripheral innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkman, C -- Porter, R -- Norman, J -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fingers/physiology ; Forearm/*innervation/physiology ; Hand/innervation/physiology ; Humans ; Macaca fascicularis ; Macaca nemestrina ; Median Nerve/physiology ; *Movement ; *Neuronal Plasticity ; Radial Nerve/physiology ; Thumb/physiology ; Ulnar Nerve/physiology
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  • 26
    Publication Date: 1983-10-07
    Description: Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M C -- Nuttall, A L -- Masta, R I -- NS-05785/NS/NINDS NIH HHS/ -- NS-07106/NS/NINDS NIH HHS/ -- NS-15107/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):69-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623058" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Cochlea/*physiology ; Electric Stimulation ; Guinea Pigs ; Hair Cells, Auditory/*physiology ; Hair Cells, Auditory, Inner/*physiology ; Hearing/*physiology
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  • 27
    Publication Date: 1983-08-19
    Description: Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinckerhoff, C E -- Coffey, J W -- Sullivan, A C -- AM14780/AM/NIADDK NIH HHS/ -- P60 AM20641/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):756-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis/*drug therapy ; Arthritis, Experimental/*drug therapy ; Female ; Fibrinogen/blood ; Inflammation/drug therapy ; Male ; Microbial Collagenase/biosynthesis ; Prostaglandins E/biosynthesis ; Rats ; Sex Factors ; Tretinoin/*therapeutic use
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capron, Alexander M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644013" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; Humans ; Mandatory Programs ; *Public Policy ; *Tissue Donors ; *Tissue and Organ Procurement ; United States ; Voluntary Programs
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-01
    Description: The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features. The cells are found in different positions in the animal, however, and differ in neuronal branching, connectivity, and function. These structural and functional differences are not seen when cells are placed in similar positions by mutation or laser-induced damage. Thus, some, but probably not all, of the differentiated properties of these cells are a consequence of their cellular environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chalfie, M -- Thomson, J N -- Sulston, J E -- AI19399/AI/NIAID NIH HHS/ -- GM30997/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857263" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis/*growth & development/physiology ; Insects/growth & development/physiology ; Movement ; Nervous System/*growth & development ; Nervous System Physiological Phenomena ; Neurons, Afferent/physiology ; Synapses/physiology ; Touch/physiology
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  • 30
    Publication Date: 1983-01-28
    Description: The defensive siphon and gill withdrawal reflex of Aplysia is a simple reflex mediated by a well-defined neural circuit. This reflex exhibits classical conditioning when a weak tactile stimulus to the siphon is used as a conditioned stimulus and a strong shock to the tail is used as an unconditioned stimulus. The siphon withdrawal component of this reflex can be differentially conditioned when stimuli applied to two different sites on the mantle skin (the mantle shelf and the siphon) are used as discriminative stimuli. The differential conditioning can be acquired in a single trial, is retained for more than 24 hours, and increases in strength with increased trials. Differential conditioning can also be produced within the field of innervation of a single cluster of sensory neurons (the LE cluster) since two separate sites on the siphon skin can serve as discriminative stimuli. The finding that two independent afferent inputs that activate a common set of interneurons and motor neurons can be differentially conditioned restricts the possible cellular loci involved in the associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carew, T J -- Hawkins, R D -- Kandel, E R -- 5KO2 M0081/PHS HHS/ -- 5KO5 MH18558/MH/NIMH NIH HHS/ -- NS 12744/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681571" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Aplysia/*physiology ; Conditioning, Classical/*physiology ; *Defense Mechanisms ; Humans ; Memory ; Reflex
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  • 31
    Publication Date: 1983-01-28
    Description: A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation has no effect on starch digestion in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, G L -- Li, B U -- Bass, P -- Olsen, W A -- 5P30 AM 26659/AM/NIADDK NIH HHS/ -- AM 13927/AM/NIADDK NIH HHS/ -- AM 21668/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6184780" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*antagonists & inhibitors ; Blood Glucose/metabolism ; Dietary Carbohydrates/*metabolism ; Humans ; Hydrogen/metabolism ; Insulin/blood ; alpha-Amylases/*antagonists & inhibitors
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charrow, R P -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857235" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/*legislation & jurisprudence ; Drug Industry ; *Drug Prescriptions ; Humans ; United States
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  • 33
    Publication Date: 1983-08-12
    Description: Of 76 cutaneously activated neurons recorded from the ventral posterior thalamus of awake, behaving monkeys, nine were weakly excited by innocuous skin stimulation and responded maximally only when noxious mechanical cutaneous stimuli were delivered within small, contralateral receptive fields. These results show that neurons capable of encoding the spatial and temporal features of noxious stimuli are located in the ventral posterior thalamus of the awake primate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casey, K L -- Morrow, T J -- NS 12581/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):675-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Consciousness/physiology ; Electric Stimulation ; Neurons, Afferent/physiology ; Pain/*physiopathology ; Physical Stimulation ; Rats ; Saimiri ; Thalamic Nuclei/physiology ; Thalamus/cytology/*physiology
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  • 34
    Publication Date: 1983-03-25
    Description: Extracellular single-unit recording techniques were used to test the ability of proglumide to block cholecystokinin-induced excitation of rat midbrain dopaminergic neurons and dopamine-sensitive prefrontal cortex cells. Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity. This selective blockade of central cholecystokinin effects by proglumide suggests that this drug may be valuable for studying the possible role of cholecystokinin as a neurotransmitter or neuromodulator in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiodo, L A -- Bunney, B S -- MH-25642/MH/NIMH NIH HHS/ -- MH-28849/MH/NIMH NIH HHS/ -- NS-07136/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Cerebral Cortex/physiology ; Cholecystokinin/*pharmacology ; Drug Antagonism ; Glutamine/*analogs & derivatives ; Male ; Mesencephalon/physiology ; Neurons/drug effects/*physiology ; Proglumide/*pharmacology ; Rats
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-26
    Description: The rate of increase of population in less developed countries accelerated rapidly from 1850 to 1960 because of a rapid decline in mortality while fertility remained high. In the 1960's, the birth rate as a whole began to decline more rapidly than the death rate--very rapidly in some populations, most notably that of China, more gradually in others, and not at all in some of the poorest populations. The momentum of growth implies continued increase in populations for several decades even in countries where fertility has fallen the most, and very large additional increases where there has been no decline in the rate of childbearing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coale, A J -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):828-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879179" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Birth Rate ; *Developing Countries ; Female ; *Fertility ; Humans ; Marriage ; Parity ; Pregnancy
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):828-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6138857" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; DNA, Recombinant ; Gene Expression Regulation ; Nerve Tissue Proteins/*genetics ; Neurotransmitter Agents/*physiology ; Rats
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  • 37
    Publication Date: 1983-04-29
    Description: Brief deprivation of vision after unilateral lesions of the frontal eye field prevents the appearance of contralateral inattention to visual, auditory, and somatosensory stimuli. The forced circling that accompanies inattention, however, is not affected. An equivalent preoperative period in the dark only partly reduces inattention symptoms. Visual deprivation does not reduce or prevent inattention resulting from lesions of the superior colliculus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowne, D P -- Richardson, C M -- Ward, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):527-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836298" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention/*physiology ; Darkness ; Frontal Lobe/*physiology ; Male ; Movement ; Rats ; Sensory Deprivation/*physiology ; Superior Colliculi/*physiology ; Visual Perception/*physiology
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: A comparison between eukaryotic gene sequences and protein sequences of homologous enzymes from bacterial and mammalian organisms shows that intron-exon junctions frequently coincide with variable surface loops of the protein structures. The altered surface structures can account for functional differences among the members of a family. Sliding of the intron-exon junctions may constitute one mechanism for generating length polymorphisms and divergent sequences found in protein families. Since intron-exon junctions map to protein surfaces, the alterations mediated by sliding of these junctions can be effected without disrupting the stability of the protein core.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Craik, C S -- Rutter, W J -- Fletterick, R -- AM21344/AM/NIADDK NIH HHS/ -- AM26081/AM/NIADDK NIH HHS/ -- GM28520/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344214" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bacterial Proteins ; Base Sequence ; Biological Evolution ; DNA/genetics ; Endopeptidases/genetics ; Eukaryotic Cells/metabolism ; Genes ; Genes, Bacterial ; Protein Conformation ; Proteins/*genetics ; *Serine Endopeptidases ; Tetrahydrofolate Dehydrogenase/genetics
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, Barbara J -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1029.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643993" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Fraud ; Humans ; *Research ; Research Personnel ; *Scientific Misconduct
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  • 40
    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
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  • 41
    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The external and internal interosseous intercostal muscles were separately stimulated at end-expiratory lung volume in anesthetized dogs. These muscles were all found to elevate the ribs into which they insert. By attaching weights to the ribs, it was determined that the nonlinear compliance of the ribs was responsible for this phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Troyer, A -- Kelly, S -- Zin, W A -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):87-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Dogs ; Electric Stimulation ; Humans ; Intercostal Muscles/anatomy & histology/*physiology ; Respiration ; Ribs/anatomy & histology/*physiology
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermer, G B -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Neoplasms ; Neoplasms, Experimental ; Rats ; Research
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeSimone, J A -- NS13767/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):221-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828892" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diffusion ; Humans ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism/*physiology ; Peptides/metabolism ; Sucrose/metabolism
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  • 45
    Publication Date: 1983-03-18
    Description: Immunohistochemical techniques were used to confirm biochemical evidence that parenchymal cells isolated from adult rat liver and maintained in nonreplicating monolayer culture for 2 days synthesized type IV basement membrane collagen. On continued incubation in serum-free medium, the hepatocytes also synthesized the interstitial collagens, types I and III. Consistent with these results in culture, type IV collagen was localized to the hepatocytes in slices of pathologic rat liver. Hence collagen formation is a previously unrecognized function of the hepatocyte that may be important in the pathogenesis of liver fibrosis or cirrhosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diegelmann, R F -- Guzelian, P S -- Gay, R -- Gay, S -- AM18976/AM/NIADDK NIH HHS/ -- DE02570/DE/NIDCR NIH HHS/ -- HL11310/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1343-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/metabolism ; Cells, Cultured ; Collagen/*biosynthesis/immunology ; Liver/cytology/*metabolism ; Molecular Weight ; Rats
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: Artificial intelligence, long a topic of basic computer science research, is now being applied to problems of scientific, technical, and commercial interest. Some consultation programs, although limited in versatility, have achieved levels of performance rivaling those of human experts. A collateral benefit of this work is the systematization of previously unformalized knowledge in areas such as medical diagnosis and geology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duda, R O -- Shortliffe, E H -- LM-00048/LM/NLM NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6340198" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; *Computers ; Diagnosis, Computer-Assisted ; Humans ; Research ; Systems Analysis
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: Nonmalignant diploid human fibroblast cells (GM3498B) derived from a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude mice--characteristics of neoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniger, J -- Di Paolo, J A -- Popescu, N C -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1144-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648529" target="_blank"〉PubMed〈/a〉
    Keywords: Bloom Syndrome/*genetics ; Cell Adhesion ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Humans ; Oncogenes ; Transfection
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doverspike, Dennis -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):506.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644015" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavioral Research ; Civil Rights ; Ethics, Professional ; Human Rights ; Humans ; *Research ; *Research Personnel ; *Scientific Misconduct ; *Social Control, Informal ; Students ; *Universities
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: The forensic use of hypnosis is increasing. A hypermnesic procedure was used in an experiment that calls this practice into question. Subjects tried for a week to recall 60 previously presented pictures. They were then either hypnotized or not and encouraged to recall even more pictures. Most of the newly recalled material was incorrect, especially for highly hypnotizable subjects in the hypnosis condition. Such errors in recall can have profound implications for forensic investigations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dywan, J -- Bowers, K -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623071" target="_blank"〉PubMed〈/a〉
    Keywords: Forensic Psychiatry/methods ; Humans ; *Hypnosis ; Memory/*physiology ; Mental Recall/*physiology
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  • 50
    Publication Date: 1983-12-23
    Description: Subfreezing temperatures, low light levels, and high doses of ionizing and ultraviolet radiation extending for many months after a large-scale nuclear war could destroy the biological support systems of civilization, at least in the Northern Hemisphere. Productivity in natural and agricultural ecosystems could be severely restricted for a year or more. Postwar survivors would face starvation as well as freezing conditions in the dark and be exposed to near-lethal doses of radiation. If, as now seems possible, the Southern Hemisphere were affected also, global disruption of the biosphere could ensue. In any event, there would be severe consequences, even in the areas not affected directly, because of the interdependence of the world economy. In either case the extinction of a large fraction of the Earth's animals, plants, and microorganisms seems possible. The population size of Homo sapiens conceivably could be reduced to prehistoric levels or below, and extinction of the human species itself cannot be excluded.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrlich, P R -- Harte, J -- Harwell, M A -- Raven, P H -- Sagan, C -- Woodwell, G M -- Berry, J -- Ayensu, E S -- Ehrlich, A H -- Eisner, T -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1293-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658451" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Climate ; *Environment ; Humans ; *Nuclear Warfare ; Photosynthesis ; Radiation, Ionizing ; Radioactive Fallout ; Sunlight ; Temperature ; Ultraviolet Rays
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3',5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eskin, A -- Takahashi, J S -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):82-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298939" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Monophosphate/physiology ; Adenylyl Cyclases/*physiology ; Animals ; Aplysia/physiology ; *Circadian Rhythm/drug effects ; Colforsin ; Cyclic AMP/physiology ; Diterpenes/pharmacology ; Eye/drug effects ; Ocular Physiological Phenomena ; Serotonin/pharmacology
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  • 52
    Publication Date: 1983-09-02
    Description: Extracts from adult human adrenals contained high concentrations of immunoreactive beta-endorphin and alpha-melanotropin. Lower quantities of immunoreactive adrenocorticotropic hormone could also be detected. Distribution studies showed the presence of pro-opiomelanocortin fragments in the adrenal medulla. No alpha-melanotropin, beta-endorphin, or adrenocorticotropic hormone could be found in adrenal extracts from several other mammalian species. Analysis of the beta-endorphin-like immunoreactivity using region specific radioimmunoassays interfacing with gel filtration and reverse-phase high-performance liquid chromatography showed the majority of the beta-endorphin-like material to exist as nonacetylated beta-endorphin-(1-31) with a small percentage of lipotropin-sized molecules. The alpha-melanotropin-like immunoreactivity cochromatographed on gel filtration and reverse-phase high-performance liquid chromatography with desacetyl alpha-melanotropin. The data suggest that pro-opiomelanocortin is expressed in the adrenal medulla of humans but is not detectable in the adrenal glands of many other mammalian species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, C J -- Erdelyi, E -- Weber, E -- Barchas, J D -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):957-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308766" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/analysis ; Adrenal Medulla/*analysis ; Adrenocorticotropic Hormone/analysis ; Endorphins/analysis ; Humans ; Melanocyte-Stimulating Hormones/analysis ; Pituitary Hormones, Anterior/*analysis/metabolism ; Pro-Opiomelanocortin ; Protein Precursors/*analysis/metabolism ; Radioimmunoassay
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  • 53
    Publication Date: 1983-07-08
    Description: Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of alpha-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after alpha-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewing, A G -- Bigelow, J C -- Wightman, R M -- KO 4 NS000356/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857277" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamine/pharmacology ; Animals ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Male ; Methyltyrosines/pharmacology ; Microelectrodes ; Naphthyridines/pharmacology ; Rats ; Rats, Inbred Strains ; alpha-Methyltyrosine
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: Three-month-old infants learned to activate an overhead crib mobile by operant footkicking and received a visual reminder of the event (a "reactivation treatment") 2 weeks later, after forgetting had occurred. Subsequent manifestation of the association was a monotonic increasing function of time since the reactivation treatment, and performance of infants tested 8 hours after the remainder was related to the time spent sleeping in the interim (r = 0.75). These data demonstrate that normal retrieval is time-dependent. Moreover, individual data suggest that retrieval may be continuous rather than discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagen, J W -- Rovee-Collier, C -- MH 32307/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658456" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Memory ; Time Factors
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  • 55
    Publication Date: 1983-05-20
    Description: The acquired immune deficiency syndrome (AIDS), which has recently occurred at increasing rates in homosexual men, intravenous drug users, and others, is characterized by the development of Kaposi's sarcoma and several opportunistic infections including pneumonia caused by Pneumocystis carinii. Serum samples from patients with AIDS and from matched and unmatched control subjects were examined for the presence of antibodies to cell membrane antigens associated with human T-cell leukemia virus. Nineteen of 75 of the AIDS patients had antibodies directed to surface antigens of Hut 102, a reference T lymphoid cell line infected with leukemia virus, as did two of the 336 control subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Essex, M -- McLane, M F -- Lee, T H -- Falk, L -- Howe, C W -- Mullins, J I -- Cabradilla, C -- Francis, D P -- 2T32CA09031/CA/NCI NIH HHS/ -- 5T32HL07523/HL/NHLBI NIH HHS/ -- CA 18216/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 20;220(4599):859-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342136" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/etiology/immunology/*microbiology ; Animals ; Antibodies, Viral/*analysis ; Antigens, Viral/immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Lymphatic Diseases/immunology ; Male ; *Retroviridae/immunology ; T-Lymphocytes/microbiology ; Tumor Virus Infections/complications/immunology/*microbiology
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  • 56
    Publication Date: 1983-09-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1161-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612329" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Dioxins/*toxicity ; Environmental Exposure ; Humans
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  • 57
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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  • 58
    Publication Date: 1983-02-18
    Description: Cerebral glucose metabolism in rats was examined 1 week after the production by ibotenic acid of unilateral striatal lesions. The incorporation of carbon-14-labeled deoxyglucose decreased within the lesion but much less than that of carbon-14-labeled glucose. Barbiturate anesthesia caused a reversal of the asymmetric striatal deoxyglucose labeling, such that the lesioned striatum retained more tracer than the contralateral side. The combined use of barbiturates and radiolabeled deoxyglucose may enhance the identification of recent brain infarction in experimental animals and in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, K A -- Agranoff, B W -- 1 T32 GM07863/GM/NIGMS NIH HHS/ -- NS 15655/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):879-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Barbiturates/*pharmacology ; Brain/*drug effects/metabolism ; Brain Diseases/chemically induced/metabolism ; Corpus Striatum/drug effects ; Deoxyglucose ; Glucose/metabolism ; Ibotenic Acid ; Rats
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-13
    Description: Cells in intermediate and deeper layers of the pigeon optic tectum respond best when a textured background pattern is moved in the opposite direction to a moving test spot. Complete inhibition occurs when the background moves in the same direction as the test stimulus. Most noteworthy is the invariance of this relationship over a wide range of test spot directions. These cells represent a higher level of abstraction in a motion-detecting system and may play a role in figure-ground segregation or the discrimination of the motion of an object from self-induced optical motion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frost, B J -- Nakayama, K -- EY-03884/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):744-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836313" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Columbidae/physiology ; Locomotion ; Motion ; Motion Perception/*physiology ; Neurons/physiology ; Superior Colliculi/*cytology/physiology ; Visual Perception/*physiology
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  • 60
    Publication Date: 1983-07-08
    Description: Infective third-stage larvae of Dipetalonema viteae (Nematoda: Filarioidea) were cultured to young adults in a cell-free culture system. Third-stage larvae from the tick vector grew, developed, and molted twice in a medium containing NCTC 135 and Iscove's modified Dulbecco's medium supplemented with fetal bovine serum under a gas phase of 95 percent nitrogen and 5 percent carbon dioxide. The availability of such a culture system for filariids should facilitate studies of their immunology, biochemistry, and sensitivity to drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Franke, E D -- Weinstein, P P -- AI 07030/AI/NIAID NIH HHS/ -- AI 09625/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):161-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Culture Media ; Dipetalonema/*growth & development ; In Vitro Techniques ; Larva ; Male ; Ticks/parasitology
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  • 61
    Publication Date: 1983-07-29
    Description: Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinal fluid were reduced to daytime levels by exposing the monkeys to continuous light or to the beta-adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garrick, N A -- Tamarkin, L -- Taylor, P L -- Markey, S P -- Murphy, D L -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):474-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm/drug effects ; Humans ; *Light ; Macaca mulatta ; Male ; Melatonin/physiology ; Propranolol/*pharmacology ; Rats ; Serotonin/*cerebrospinal fluid/physiology
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  • 62
    Publication Date: 1983-05-20
    Description: The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLV) is associated with T-cell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis of DNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelmann, E P -- Popovic, M -- Blayney, D -- Masur, H -- Sidhu, G -- Stahl, R E -- Gallo, R C -- New York, N.Y. -- Science. 1983 May 20;220(4599):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6601822" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/etiology/immunology/*microbiology ; Adult ; Animals ; Cats ; DNA, Viral/*analysis ; Humans ; Male ; Middle Aged ; *Retroviridae/genetics ; T-Lymphocytes/analysis/microbiology ; Tumor Virus Infections/complications/*microbiology
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: Giardia lamblia, a common pathogenic intestinal parasite of humans, was rapidly killed by exposure to normal human milk in vitro. The killing did not depend on secretory immunoglobulin A. Entamoeba histolytica, the dysentery amoeba, was also killed by normal human milk. Giardia-cidal activity cochromatographed with an unusual lipase that is present in the milk of humans but not of lower mammals. Human milk may play a protective role in infants exposed to this parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gillin, F D -- Reiner, D S -- Wang, C S -- AI19863/AI/NIAID NIH HHS/ -- HD14104/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1290-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310751" target="_blank"〉PubMed〈/a〉
    Keywords: Entamoeba histolytica/growth & development ; Entamoebiasis/prevention & control ; Female ; Giardia/growth & development ; Giardiasis/*prevention & control ; Humans ; Immunoglobulin A, Secretory/immunology ; Intestines/parasitology ; Milk, Human/*parasitology ; Trichomonas Infections/prevention & control ; Trichomonas vaginalis/growth & development
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glenn, L L -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):527-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623095" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Brain Stem/physiology ; Electric Stimulation ; Heart/*innervation ; Humans ; Locomotion ; Lung/*innervation ; *Respiration
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-01
    Description: Although the conductance and kinetic behavior of inhibitory synaptic channels have been studied in a number of nerve and muscle cells, there has been little if any detailed study of such channels at synapses in the vertebrate central nervous system or of the relation of such channels to natural synaptic events. In the experiments reported here, current noise measurements were used to obtain such information at synapses on Muller cells in the lamprey brainstem. Application of glycine to the cells activated synaptic channels with large conductances and relaxation time constants (70 picosiemens and 33 milliseconds, respectively, at 3 degrees to 10 degrees C). Spontaneous inhibitory synaptic currents had a mean conductance of 107 nanosiemens and decayed with the same time constant. In addition, the glycine responses and the spontaneous currents had the same reversal potential and both were abolished by strychnine. These results support the idea that glycine is the natural inhibitory transmitter at these synapses and suggest that one quantum of transmitter activates about 1500 elementary conductance channels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, M R -- Martin, A R -- NS-06283/NS/NINDS NIH HHS/ -- NS-09660/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857271" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Stem/*physiology ; Glycine/pharmacology ; Lampreys/physiology ; Neural Conduction/drug effects ; *Neural Inhibition/drug effects ; Strychnine/pharmacology ; Synapses/drug effects/*physiology
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: Behavior of squirrel monkeys, maintained by the termination of stimuli associated with electric shock, was suppressed by response-dependent shock delivery. The effects of pentobarbital on this behavior depended on whether monkeys had previously received morphine. In monkeys without experience with drugs, pentobarbital increased responding. In monkeys with recent experience with morphine, however, pentobarbital resulted in a smaller increase or decrease in responding. The rate-decreasing effects of pentobarbital after a history of morphine administration could be reversed by the administration of d-amphetamine. These findings suggest that the behavioral effects of abused drugs may depend on previous experience with other drugs, even when those drugs are from a different pharmacological class.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glowa, J R -- Barrett, J E -- DA 02658/DA/NIDA NIH HHS/ -- DA 02873/DA/NIDA NIH HHS/ -- MH 07658/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):333-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Dextroamphetamine/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Macaca mulatta ; Male ; Morphine/pharmacology ; Pentobarbital/*pharmacology ; Saimiri ; Substance-Related Disorders/physiopathology
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-27
    Description: Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term test for carcinogenicity and mutagenicity. Glutathione is positive in the test even at concentrations found in mammalian tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glatt, H -- Protic-SabljiC, M -- Oesch, F -- New York, N.Y. -- Science. 1983 May 27;220(4600):961-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cysteine/*pharmacology ; Glutathione/*pharmacology ; Histidine/metabolism ; Hydrogen Peroxide/metabolism ; Kidney/metabolism ; Liver/metabolism ; *Mutagenicity Tests ; Mutagens/*pharmacology ; Rats ; Salmonella typhimurium/metabolism
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  • 68
    Publication Date: 1983-07-08
    Description: In the parafoveal retina of human observers, cone-mediated sensitivity to flicker decreases as rods become progressively more dark-adapted. This effect is greatest when a rod response to flicker is precluded. These results indicate that rods tonically inhibit cone pathways in the dark.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, S H -- Frumkes, T E -- Nygaard, R W -- EY01802/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857279" target="_blank"〉PubMed〈/a〉
    Keywords: Dark Adaptation ; Flicker Fusion/physiology ; Humans ; Neural Inhibition ; Photoreceptor Cells/*physiology ; Retina/*physiology
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-19
    Description: Neuronal systems involved in the initiation of cocaine reinforcement were investigated by identifying brain sites where direct application of the drug was reinforcing. This was accomplished by allowing rats to self-administer picomolar concentrations of cocaine into discrete brain regions. The medial prefrontal cortex supported self-administration, while the nucleus accumbens and ventral tegmental area did not. Self-administration could be attenuated by including equimolar concentrations of the dopaminergic D2-receptor antagonist sulpiride in the microinjection system. These results imply that cocaine reinforcement is mediated in part through a direct action on mesocortical dopaminergic receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goeders, N E -- Smith, J E -- DA-01999-04/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cerebral Cortex/*drug effects/physiology ; Cocaine/*pharmacology ; Dopamine/*physiology ; Male ; Nucleus Accumbens/physiology ; Rats ; Self Administration ; Sulpiride/pharmacology
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  • 70
    Publication Date: 1983-08-19
    Description: Cocaine elicited dose-related rotation (circling) in naive rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glick, S D -- Hinds, P A -- Shapiro, R M -- DA 01044/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/*pharmacology ; Dextroamphetamine/pharmacology ; Female ; Functional Laterality ; Male ; Movement/*drug effects ; Rats ; Rotation ; Sex Factors
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, J E -- Yen, S H -- Chiu, F C -- Peress, N S -- AG 01136/AG/NIA NIH HHS/ -- NS 02476/NS/NINDS NIH HHS/ -- NS 17125/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1082-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308771" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens/analysis ; Brain/ultrastructure ; Histocytochemistry ; Humans ; Immunoenzyme Techniques ; Inclusion Bodies/*analysis/immunology ; Intermediate Filament Proteins/*analysis/immunology ; Parkinson Disease/*pathology
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  • 72
    Publication Date: 1983-07-22
    Description: Young deaf children who were unable to acquire oral language naturally and who had not been exposed to a conventional manual language were found to use spontaneously a gesture system that has some of the structural characteristics of early child language. The structural aspects of this gesture system appeared to be neither modeled for the child by the gestures of an adult nor shaped by the responses of an adult. These findings suggest that the child may contribute to structural aspects of the system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldin-Meadow, S -- Mylander, C -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):372-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867713" target="_blank"〉PubMed〈/a〉
    Keywords: Child Language ; Child, Preschool ; Communication ; Deafness/*psychology ; Humans ; Infant ; *Language Development ; *Manual Communication ; Parent-Child Relations ; *Sign Language
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-17
    Description: Weak, pulsing electromagnetic fields can modify biological processes. The hypothesis that responses to such induced currents depend on pulse characteristics was evaluated by using transcription as the target process. Two pulses in clinical use, the repetitive single pulse and the repetitive pulse train, were tested. These pulses produced different results from each other and from controls when transcription in dipteran salivary gland cells was monitored with tritiated uridine in transcription autoradiography, cytological nick translation, and analysis of isolated RNA fractions. The single pulse increased the specific activity of messenger RNA after 15 and 45 minutes of exposure. The pulse train increased specific activity only after 45 minutes of exposure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R -- Bassett, C A -- Henderson, A S -- 1ROI CA 29340/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857248" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Diptera ; Dose-Response Relationship, Radiation ; *Electromagnetic Fields ; *Electromagnetic Phenomena ; RNA, Messenger/metabolism ; Salivary Glands/metabolism ; Transcription, Genetic/*radiation effects
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  • 74
    Publication Date: 1983-05-27
    Description: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: An important question concerning the mechanism of somatic mutation of immunoglobulin variable (V) genes is whether it involves all of the numerous V genes in a differentiated B cell, independent of location, or if it is restricted to a particular chromosomal site. Comparison of the sequence of two alleles of a given V gene shows that the mutations are limited to the rearranged V gene, while the same V gene on the other chromosome has not undergone mutation. This indicates that a V gene sequence alone is not sufficient for somatic mutation to take place. The mutation is therefore restricted to the rearranged V gene and consequently does not occur before rearrangement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorski, J -- Rollini, P -- Mach, B -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1179-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; Chromosomes/physiology ; DNA/genetics ; *Genes ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulins/genetics ; Lymphocytes/metabolism ; Mice ; *Mutation
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  • 77
    Publication Date: 1983-08-19
    Description: Flatfish provide a natural model for the study of adaptive changes in the vestibulo-ocular reflex system. During metamorphosis their vestibular and oculomotor coordinate systems undergo a 90 degree relative displacement. As a result, during swimming movements different types of compensatory eye movements are produced before and after metamorphosis by the same vestibular stimulation. Intracellular staining of central nervous connections in the flatfish with horseradish peroxidase revealed that in postmetamorphic fish secondary horizontal semicircular canal neurons contact vertical eye muscle motoneuron pools on both sides of the brain via pathways that are absent in all other vertebrates studied.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graf, W -- Baker, R -- 13742/PHS HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):777-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603656" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Fishes/anatomy & histology/*physiology ; Metamorphosis, Biological ; Neuronal Plasticity ; Oculomotor Muscles/*physiology ; Vestibule, Labyrinth/innervation/*physiology
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  • 78
    Publication Date: 1983-04-08
    Description: Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grafstrom, R C -- Fornace, A J Jr -- Autrup, H -- Lechner, J F -- Harris, C C -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828890" target="_blank"〉PubMed〈/a〉
    Keywords: Bronchi/*cytology/drug effects ; Cells, Cultured ; *DNA/biosynthesis ; DNA Repair/*drug effects ; Epithelium/drug effects ; Fibroblasts/drug effects ; Formaldehyde/*pharmacology ; Humans
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-04
    Description: The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyette, M -- Petropoulos, C J -- Shank, P R -- Fausto, N -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):510-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Tetrachloride Poisoning ; DNA/biosynthesis ; Hepatectomy ; *Liver Regeneration ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/biosynthesis ; Rats ; Sarcoma Viruses, Murine/genetics ; Time Factors ; *Transcription, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: Consistency of hand preference was examined in a longitudinal study of children between 18 and 42 months of age. Results showed a sex-specific relationship between hand consistency and intellectual development. Across a variety of intellectual abilities at all ages, females with consistency of handedness were precocious compared to females without such consistency. This relationship did not hold for males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottfried, A W -- Bathurst, K -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879205" target="_blank"〉PubMed〈/a〉
    Keywords: Child, Preschool ; Female ; *Functional Laterality ; Humans ; Infant ; *Intelligence ; Intelligence Tests ; Male ; Sex Factors ; Time Factors
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: The 70,000-dalton core polypeptide of neurofilaments, thought to exist only in neurons, has been detected in chicken erythrocytes, where it coexists with vimentin and synemin as a component of the intermediate filament network. It is present in the circulating erythroid cells of embryos and young chickens but is nearly absent from the erythroid cells of adults. These findings are inconsistent with current models of intermediate filament expression, but provide another example of unexpected similarities between the nervous and hemopoietic systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Granger, B L -- Lazarides, E -- GM06965/GM/NIGMS NIH HHS/ -- RR07003/RR/NCRR NIH HHS/ -- T32 GM07616/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):553-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6346488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo ; Chickens ; Cytoskeleton/immunology/metabolism/physiology ; Electrophoresis, Polyacrylamide Gel ; Erythrocytes/*metabolism/ultrastructure ; Fluorescent Antibody Technique ; Intermediate Filament Proteins/immunology/*metabolism/physiology ; Microscopy, Electron ; Molecular Weight ; Peptides/metabolism ; Vimentin
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  • 82
    Publication Date: 1983-09-02
    Description: Isolation of epidermal lamellar bodies has presented a challenge because pressures required to homogenize keratinocytes can destroy these organelles and because the lamellar body readily releases its contents during prolonged isolation procedures. In an attempt to isolate lamellar bodies, sheets of intact stratum corneum and stratum granulosum were obtained from neonatal mice with highly purified staphylococcal epidermolytic toxin, disrupted, and passed through a series of filters. The final filtrate was rich in intact lamellar bodies and contained variable amounts of ribosomes and other vesicular structures. Availability of a highly purified lamellar body preparation from postnatal epidermis should help to clarify the role of this organelle in epidermal function. The technique of selective, sequential filtration represents a new approach to cell fractionation that may have wide applications in cell biology and biochemistry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grayson, S -- Johnson-Winegar, A D -- Elias, P M -- AM 19098/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):962-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879194" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Fractionation/methods ; Epidermis/*ultrastructure ; Filtration ; Mice ; Microscopy, Electron
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  • 83
    Publication Date: 1983-09-16
    Description: The saccadic system accurately compensates for perturbations of eye position produced by microstimulation of the superior colliculus. This requires that information about the stimulation-induced change in eye position be provided by an extraretinal source--either proprioceptive endings in extraocular muscles or a centrally generated corollary discharge. It is shown that compensation remains intact after elimination of extraocular muscle proprioception, demonstrating that corollary discharge provides accurate eye position information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guthrie, B L -- Porter, J D -- Sparks, D L -- F32 EY05651/EY/NEI NIH HHS/ -- P30 EY03039/EY/NEI NIH HHS/ -- R01 EY01189/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Eye Movements ; Macaca mulatta ; Oculomotor Muscles/*physiology ; Photic Stimulation ; Proprioception ; *Saccades ; Superior Colliculi/*physiology
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: A neuron's competence to form electrical synapses depends on its growth status. Experiments in situ and in cell culture with identified neurons of the snail Helisoma demonstrate that active neurite outgrowth from both potential partners must be spatially and temporally coincident for electrical synapse formation to occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hadley, R D -- Kater, S B -- Cohan, C S -- AM 19858/AM/NIADDK NIH HHS/ -- NS 15350/NS/NINDS NIH HHS/ -- NS 18819/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):466-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867723" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Electrophysiology ; Growth ; Neurons/*physiology ; Snails ; Synapses/*physiology
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-07
    Description: Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grumet, M -- Rutishauser, U -- Edelman, G M -- AI-11378/AI/NIAID NIH HHS/ -- HD-09635/HD/NICHD NIH HHS/ -- HD-16550/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):60-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Antigen-Antibody Complex ; *Cell Adhesion ; Cell Membrane/immunology ; Cells, Cultured ; Chick Embryo ; Epitopes ; Immunoglobulin Fab Fragments ; Neuroglia/*physiology ; Neurons/immunology/*physiology
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-16
    Description: In vitro binding studies have demonstrated the existence of multiple opiate receptor types. An additional site in the rat brain (termed the lambda site) is distinct from the established types by its selectivity for 4,5-epoxymorphinans (such as naloxone and morphine). While the lambda site displays a high affinity for naloxone in vivo and in vitro in fresh brain membrane homogenates, these sites rapidly convert in vitro to a state of low affinity. The regional distribution of the lambda site in the brain is strikingly different from that of the classic opiate receptor types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grevel, J -- Sadee, W -- AG 031047/AG/NIA NIH HHS/ -- DA 01095/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310750" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Dihydromorphine/metabolism ; Diprenorphine/metabolism ; Morphine/metabolism ; Nalorphine/metabolism ; Naloxone/*metabolism ; Naltrexone/metabolism ; Rats ; Receptors, Opioid/*metabolism ; Sodium/metabolism ; Tissue Distribution
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: In vitro fertilization, in its first 5 years of use, has met minimum standards for efficacy and safety, as judged by published clinical reports. It is becoming more widely available as an approach for overcoming sterility in married couples and appears also to be gaining social acceptance in that context. Several technical options presented by the procedure, particularly storage of frozen embryos and embryo transfers involving third-party contributions, are less fully evaluated clinically and raise social, ethical, and legal questions that go beyond the original medical model for therapeutic intervention. The clinical success of in vitro fertilization and the options it affords call for careful policy consideration. Estimates of costs and of potential demand for and supply of services are provided and the current status of relevant policy in the United States and abroad is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grobstein, C -- Flower, M -- Mendeloff, J -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):127-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623063" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Costs and Cost Analysis ; Embryo Transfer ; Ethical Review ; Ethics ; Fallopian Tube Diseases/therapy ; Federal Government ; Female ; Fertilization in Vitro/*methods ; Humans ; Infertility, Female/therapy ; Infertility, Male/therapy ; Legislation, Medical ; Male ; Obstetrics/economics/standards ; Oocyte Donation ; Pregnancy ; Resource Allocation ; *Risk Assessment ; during its first five years. Efficacy, safety, costs, demand and supply, and ; feasible extensions of the basic procedure are discussed. The authors contend ; that, while Australia and Great Britain have made progress toward formulating ; public policy on IVF, efforts in the United States have not gone beyond a 1979 ; report and recommendations issued by the Department of Health, Education, and ; Welfare's Ethics Advisory Board. Given the ready clinical and public acceptance ; of IVF, there is need for an oversight mechanism at the federal level, perhaps ; via a forum concerned also with the overlapping area of human genetic ; intervention.
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase. This enzyme, unlike platelet peroxidase, is not inhibited by glutaraldehyde. The myeloperoxidase and acid hydrolase levels and continuous plasma membranes of these cell-like particles suggest that they are functional cellular entities. They further differ from platelets in that they contain nuclear remnants, occur in bacteria-laden pus and inflammatory exudates, are ingested by macrophages, and do not adhere to each other or aggregate. They could be involved in the immune response to pathogens or contribute to trauma and healing by facilitating deployment of neutrophil acid hydrolase, neutral protease, and myeloperoxidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanker, J S -- Giammara, B L -- DE 02668/DE/NIDCR NIH HHS/ -- DE 05333/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301006" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Cells/*cytology/physiology ; Blood Platelets/*cytology/physiology ; Cell Nucleus/physiology ; Humans ; Inflammation/physiopathology ; Microscopy, Electron ; Neutrophils/*cytology/physiology ; Peroxidase
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: Massive dendritic sprouting was induced in identified giant reticulospinal neurons of the lamprey by axotomy close to the soma. An axonal lesion slightly farther from the cell body induced new growth from both dendrites and axon. The amount of new growth per cell was the same whether it originated from the dendrites alone or from axonal and dendritic compartments. The location of the axonal lesion therefore determines where, in the neuron, membrane is inserted to produce the new neurites. The dendritic tree of a differentiated vertebrate central neuron was shown to have sufficient plasticity to extend new growth for several millimeters beyond the normal dendritic domain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, G F -- Cohen, M J -- 2P50 NS 10174-10/NS/NINDS NIH HHS/ -- GM 07527/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):518-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623092" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Brain/*physiology ; Dendrites/*physiology ; Lampreys ; *Nerve Regeneration ; Neurons/*physiology
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  • 90
    Publication Date: 1983-09-09
    Description: Visually evoked responses to counterphased gratings were recorded from the cat visual cortex before and after physostigmine administration. Physostigmine markedly reduced the responses to low spatial frequencies, but minimally affected the response to high frequencies. This effect is considered cholinergic since it could be reversed by atropine. These results support at least a two-channel model of spatial frequency responsivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harding, T H -- Wiley, R W -- Kirby, A W -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1076-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879206" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/pharmacology ; Cats ; Evoked Potentials, Visual ; Models, Neurological ; Parasympathetic Nervous System/*physiology ; Physostigmine/pharmacology ; *Vision, Ocular/drug effects ; Visual Cortex/*physiology
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  • 91
    Publication Date: 1983-03-25
    Description: Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harlan, R E -- Shivers, B D -- Pfaff, D W -- HD-05585/HD/NICHD NIH HHS/ -- HD-05737/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828874" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Castration ; Cerebral Cortex/drug effects/*physiology ; Cosyntropin/pharmacology ; Estradiol/pharmacology ; Female ; Growth Hormone/pharmacology ; Immune Sera ; Kinetics ; Mesencephalon/*physiology ; Oxytocin/pharmacology ; Posture ; Prolactin/administration & dosage/*pharmacology ; Rats ; Sexual Behavior, Animal/*drug effects ; Vasopressins/pharmacology
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-02
    Description: Microspectrophotometric measurements of optically isolated photoreceptors in the Japanese dace, a cyprinid fish, revealed four spectroscopically distinguishable cone pigments and one rod pigment. A visual pigment that absorbs in the near ultraviolet was found in small single cones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harosi, F I -- Hashimoto, Y -- EY02399/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1021-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648514" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyprinidae/*metabolism ; Photoreceptor Cells/*analysis ; Retinal Pigments/*analysis ; Rod Cell Outer Segment/analysis ; Spectrophotometry, Ultraviolet
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  • 93
    Publication Date: 1983-04-15
    Description: Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haspel, M V -- Onodera, T -- Prabhakar, B S -- Horita, M -- Suzuki, H -- Notkins, A L -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301002" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology/*microbiology ; Endocrine Glands/*immunology ; Enzyme-Linked Immunosorbent Assay ; Growth Hormone/immunology ; Humans ; Hybridomas/immunology ; Mice ; Pituitary Gland, Anterior/immunology ; Rats ; Reoviridae Infections/*immunology
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: Histone octamers from calf thymus were separated into (H3:H4)2 tetramers and H2A:H2B dimers by chromatography through Sephadex G100. The tetramers and dimers were analyzed for variants, ubiquitin adducts, and proteolyzed forms. The minor histone variants H2A.X and H2A.Z were found to be associated with histone H2B as H2A.X:H2B and H2A.Z:H2B dimers, respectively. Ubiquitin adducts of the H2A's and H2B were also present in H2A:H2B dimers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hatch, C L -- Bonner, W M -- Moudrianakis, E N -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):468-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306766" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Chromatography, Gel ; Chromosomal Proteins, Non-Histone/*metabolism ; Electrophoresis, Polyacrylamide Gel ; Histones/isolation & purification/*metabolism ; Ubiquitins
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Female mice that had been situated in utero between two female fetuses displayed higher levels of active avoidance responding in adult life than females that had been located between two male fetuses and males for whom uterine position was without effect. Uterine position, therefore, influences acquired as well as species-typical behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hauser, H -- Gandelman, R -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836288" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/physiology ; Animals ; Avoidance Learning/*physiology ; Female ; Fetus/*physiology ; Male ; Mice ; Pregnancy ; Rats ; Sex Factors ; Uterus
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  • 96
    Publication Date: 1983-01-28
    Description: A training procedure analogous to differential classical conditioning produces differential facilitation of excitatory postsynaptic potentials (EPSP's) in the neuronal circuit for the siphon withdrawal reflex in Aplysia. Thus, tail shock (the unconditioned stimulus) produces greater facilitation of the monosynaptic EPSP from a siphon sensory neuron to a siphon motor neuron if the shock is preceded by spike activity in the sensory neuron than if the shock and spike activity occur in a specifically unpaired pattern or if the shock occurs alone. Further experiments indicate that this activity-dependent amplification of facilitation is presynaptic in origin and involves a differential increase in spike duration and thus in Ca2+ influx in paired versus unpaired sensory neurons. The results of these cellular experiments are quantitatively similar to the results of behavioral experiments with the same protocol and parameters, suggesting that activity-dependent amplification of presynaptic facilitation may make a significant contribution to classical conditioning of the withdrawal reflex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkins, R D -- Abrams, T W -- Carew, T J -- Kandel, E R -- 5K02 MH0081/MH/NIMH NIH HHS/ -- 5KO5 MH 18558/MH/NIMH NIH HHS/ -- 5T32NS07062-06/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):400-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294833" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Afferent Pathways/physiology ; Animals ; Aplysia/*physiology ; Calcium/physiology ; Conditioning, Classical/*physiology ; Learning/*physiology ; Motor Neurons/physiology ; Reflex ; Synaptic Transmission
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, C W Jr -- Nadel, M R -- Zack, M M -- Chen, A T -- Bender, M A -- Preston, R J -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879190" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Humans ; New York ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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  • 98
    Publication Date: 1983-06-10
    Description: A phosphorus-31 nuclear magnetic resonance imaging technique has been used to obtain information on phosphorus metabolites from different spatial regions of tissues in vivo. The technique for selection of planes through the tissue is based on phase-encoding of spin echoes and was used to obtain one-dimensional discrimination of phosphorus-31 spectra from different parts of the tissue simultaneously. Specimens were resolved into 16 distinct slices and a signal-to-noise ratio of about 20 to 1 was obtained in 1/2 hour. Results are presented for phantoms, rat legs, and gerbil heads.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haselgrove, J C -- Subramanian, V H -- Leigh, J S Jr -- Gyulai, L -- Chance, B -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1170-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857240" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Gerbillinae ; Magnetic Resonance Spectroscopy/*methods ; Phosphocreatine/metabolism ; Phosphoric Acids/metabolism ; Phosphorus/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 1983-12-23
    Description: Endotoxin-free thymosin fraction 5 elevated corticotropin, beta-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and beta-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Healy, D L -- Hodgen, G D -- Schulte, H M -- Chrousos, G P -- Loriaux, D L -- Hall, N R -- Goldstein, A L -- CA 24974/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318312" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Dose-Response Relationship, Drug ; Endorphins/blood ; Female ; Hydrocortisone/blood ; Kinetics ; Macaca fascicularis ; Thymectomy ; Thymosin/analogs & derivatives/*pharmacology ; Thymus Gland/*physiology ; beta-Endorphin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 1983-04-29
    Description: Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedlund, B -- Abens, J -- Bartfai, T -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/*pharmacology ; Gastrointestinal Hormones/*metabolism ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*drug effects ; Receptors, Muscarinic/analysis/*drug effects ; Salivary Glands/analysis/innervation ; Vasoactive Intestinal Peptide/analysis/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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