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  • Humans  (6,660)
  • Reproducibility of Results  (484)
  • Physics
  • Nature Publishing Group (NPG)  (6,895)
  • Logos Verlag Berlin  (37)
  • 1
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-11
    Description: While binaural technology applications gained in popularity in recent years, the majority of applications still use non-individual Head-Related Transfer Functions (HRTFs) from artificial heads. However, certain applications, for example research of spatial hearing or hearing attention, require an physically exact and realistic binaural signal. The limiting factor that prohibits the widespread use of individual HRTFs is the acquisition time of such data. This time requirement has recently been reduced by the use of parallelization in the measurement signal which lead to the development of fast measurement systems capable of acquiring individual and spatially dense HRTF. This thesis provides a objective and subjective evaluation of such a system that is designed with the goal of little disturbance of the measurements in mind. The construction is detailed, followed by both an objective and subjective evaluation. A detailed investigation into additional distortion of the sound field introduced by the system itself is presented and it is shown that the system performs comparably to a conventional system in terms of sound source localization. Furthermore, a method is introduced and evaluated to further reduce the measurement time by using continuous rotation during the measurement. This method is used to reduced the measurement duration from eight minutes to three minutes without audible differences.
    Keywords: Technology & Engineering ; Electronics ; Science ; Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 2
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Die Teilchenphysik als Teilgebiet der modernen Physik gewinnt zunehmend an Bedeutung im schulischen Physikunterricht. In dieser Arbeit wird erstmalig das von Lehrkräften benötigte Fachwissen zur Teilchenphysik modelliert, wobei Fachwissen als ein Teil des Professionswissens verstanden wird. Als Fachwissensdimensionen werden die Inhaltsbereiche und die Wissensarten in den Fokus genommen, für welche jeweils Subfacetten identifiziert und präzise beschrieben werden. Nach einem überblick über die wesentlichen Ideen der Teilchenphysik wird in der Arbeit die sukzessive Modellierung des Fachwissens im Rahmen einer qualitativ und quantitativ angelegten Delphi-Studie vorgestellt. In drei Befragungsrunden wurden zwischen 35 und 65 internationale Expertinnen und Experten aus der teilchenphysikbezogenen Forschung (Fachwissenschaft und Fachdidaktik) und öffentlichkeitsarbeit (u.a. Wissenschaftsjournalismus) sowie erfahrene Lehrkräfte zu den für das Fachwissen relevanten Themen der Teilchenphysik befragt. Empirische Analysen der Befragungsrunden ergaben, dass sich die Dimension Inhaltsbereiche im deklarativen Wissen aus zehn teilchenphysikalischen Themen (z.B. Teilchen in der Hochenergiephysik, die vier fundamentalen Wechselwirkungen) zusammensetzt, von welchen sechs als besonders relevant eingeschätzt wurden. Im Anschluss an die letzte Befragungsrunde wurde theoriegeleitet eine erste Modellierung der Inhaltsbereiche für die Wissensarten des prozeduralen und konditionalen Wissens vorgenommen.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 3
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: Die in den vergangenen Jahren zahlreich entstandenen außerschulischen Lernorte an der deutschen Wattenmeerküste sind Ausdruck einer Differenzierung der dortigen Bildungslandschaft, in der schulisches durch non-formales Lernen im regionalen Kontext ergänzt wird. Die außerschulischen Lernorte zeichnet aus, dass sie ihren Besucherinnen und Besuchern Primärerfahrungen bieten, um die außergewöhnliche Dynamik und Sensitivität des Wattenmeeres zu verdeutlichen. Allerdings schöpfen die Lernorte ihr Potenzial für das außerschulische Physiklernen nicht aus, denn obwohl insbesondere Strömungen und Strukturbildungen (z. B. Rippel, Dünen und Priele) das Erscheinungsbild des Wattenmeers prägen und dessen Dynamik repräsentieren, werden in den Bildungsangeboten bisher fast ausschließlich biologische Inhalte behandelt. Deshalb ist physikdidaktische Forschungs- und Entwicklungsarbeit nötig, die durch eine Didaktische Rekonstruktion von Strömungen und Strukturbildungen geleistet wird. Hierzu gehört zunächst eine fachliche Klärung. Im Anschluss werden Lernendenvorstellungen untersucht, indem problemzentrierte Interviews entlang von Realexperimenten durchgeführt und einer qualitativen Inhaltsanalyse unterworfen werden. Auf Basis des Vergleichs zwischen fachlicher Sicht und Lernendensicht gilt es sodann, Bausteine für didaktische Strukturierungen zu entwickeln. Diese Bausteine werden schließlich eingesetzt, um gemeinsam mit den Lernortbetreibenden Bildungsangebote zu entwickeln, die auch physikalische Zusammenhänge zur Küstendynamik explizieren.
    Keywords: Science ; Earth Sciences ; Education ; Science ; Physics ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 4
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: Problemlösen ist eine wesentliche Voraussetzung für das Handeln in allen Bereichen des Lebens: In einfachen Alltagssituationen, bei (natur-) wissenschaftlichen Fragestellungen oder bei komplexeren gesellschaftlich relevanten Problemen spielt die Lösung von Problemen eine Rolle. Im Bereich der Physik werden insbesondere innerhalb des schulischen und universitären Kontextes Probleme bearbeitet. Die täglichen Erfahrungen des Lehrbetriebs an Hochschulen machen jedoch deutlich, dass Teile der Studierenden große Schwierigkeiten haben, Probleme erfolgreich zu lösen. Die Diskrepanz zwischen der Wichtigkeit des Problemlösens und den Schwierigkeiten, die Studierenden dabei haben, ist der Ausgangspunkt für die zentrale Fragestellung der vorliegenden Arbeit: Was unterscheidet "gute" von "schlechten" Problemlösern und welche Faktoren beeinflussen den Erfolg beim Problemlösen? Die Arbeit fokussiert hierbei auf Probleme aus dem Themenfeld der Mechanik. Mit Hilfe einer empirischen Untersuchung wird dazu beigetragen, bereits bekannte Erkenntnisse aus der traditionsreichen Forschung zum Problemlösen zu bestätigen, zu quantifizieren und zueinander in Beziehung zu setzen. Es werden sowohl quantitative als auch qualitative Eigenschaften "guter" und "schlechter" Problemlöser herausgearbeitet - gute Problemlöser können beispielsweise auf mehr Fachwissen zurückgreifen, besitzen ein höheres Selbstkonzept und machen weniger Planungsfehler beim Bearbeiten physikalischer Problemstellungen.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 5
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-11
    Description: Our world today is becoming increasingly complex, and technical devices are getting ever smaller and more powerful. The high density of electronic components together with high clock frequencies leads to unwanted side-effects like crosstalk, delayed signals and substrate noise, which are no longer negligible in chip design and can only insufficiently be represented by simple lumped circuit models. As a result, different physical phenomena have to be taken into consideration since they have an increasing influence on the signal propagation in integrated circuits. Computer-based simulation methods play thereby a key role. The modelling and analysis of complex multi-physics problems typically leads to coupled systems of partial differential equations and differential-algebraic equations (DAEs). Dynamic iteration and model order reduction are two numerical tools for efficient and fast simulation of coupled systems. Formodelling of low frequency electromagnetic field, we use magneto-quasistatic (MQS) systems which can be considered as an approximation to Maxwells equations. A spatial discretization by using the finite element method leads to a DAE system. We analyze the structural and physical properties of this system and develop passivity-preserving model reduction methods. A special block structure of the MQS model is exploited to to improve the performance of the model reduction algorithms.
    Keywords: Technology & Engineering ; Electronics ; Mathematics ; Science ; Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 6
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: Experimentieren kann nicht nur dazu beitragen, fachinhaltliche Erkenntnisse zu gewinnen, sondern auch selbst Lerngegenstand sein. Wenig geklärt ist bisher, wie beim Experimentieren gelernt wird, worauf zu achten ist. Unklar ist auch, welche fachmethodischen Vorstellungen Lernende beim Planen, Durchführen und Auswerten aktivieren. Diesen Fragen wurde mithilfe einer schriftlichen Instruktion nachgegangen, die Lernende (Jg. 11) anregt, nicht nur Experimente durchzuführen, sondern auch über fachmethodische Grundlagen nachzudenken. Die Arbeitsphasen wurden für 42 Schülergruppen videografiert und kategorienbasiert ausgewertet, um Aussagen über Aktivitätsprofile, Vorstellungen und Kompetenzveränderungen zu generieren. Die Ergebnisse belegen die Komplexität von Lernprozessen und zeigen die Schwierigkeit, individuelle Kompetenzzuwächse auf bestimmte Prozesse zurückzuführen. Zum Beispiel konnten hohe Kompetenzzuwächse sowohl für Lernende mit häufigen fachmethodischen Beiträgen als auch für solche mit nur geringen fachmethodischen Aktivitäten festgestellt werden. Des Weiteren gehen experimentell angemessene Aktivitäten in erkennbaren Anteilen mit fachmethodisch unpassenden Vorstellungen einher, wie z.,B. bei einer korrekt vorgenommenen, aber falsch begründeten Trennung zwischen einer Beobachtung und einer Deutung. Die Arbeit liefert damit Hinweise, dass Lernende neben fachinhaltlichen auch fachmethodische Vorstellungen in den Unterricht mitbringen. Diese gilt es z.,B. durch explizite und wiederholte Thematisierung zu adressieren.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 7
    Publication Date: 2024-04-11
    Description: In einem Solarturmkraftwerk werden hunderte bis tausende Spiegel (sogenannte Heliostate) einzeln der Sonne nachgeführt, sodass das Sonnenlicht auf die Spitze eines Turmes konzentriert wird. Dort befindet sich der Receiver, der die Solarstrahlung absorbiert und an das Wärmeträgermedium weitergibt. Große thermische Energiespeicher erlauben die ganztägige Stromproduktion (auch Nachts). In aktuellen Solarturmkraftwerken kommen als Wärmeträger- und Speichermedium häufig flüssige Nitratsalze wie Solar Salt zum Einsatz. Aufgrund ihrer hohen Wärmekapazität und den geringen Kosten eignen sie sich sehr gut zur thermischen Energiespeicherung, jedoch bringen sie auch einige Nachteile mit sich. Flüssigmetalle weisen in vielen Punkten Vorteile gegenüber den Flüssigsalzen auf. In der vorliegenden Arbeit werden die Eigenschaften von Flüssigmetallen detailliert analysiert und mit Solar Salt verglichen. Zur Bewertung werden die Jahreserträge bzw. die Stromgestehungskosten (LCOE) herangezogen. Die Ergebnisse zeigen ein Potenzial zur Reduktion der Stromgestehungskosten mit Flüssigmetallen um bis zu 16 % gegenüber dem Referenzsystem mit Solar Salt, ohne dabei den Kraftwerksblock und den thermischen Speicher zu verändern.
    Keywords: Technology & Engineering ; Construction ; Technology & Engineering ; Science ; Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 8
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-05
    Description: In 2005, the hybrid model was published by Prof. H.-D. Alber and Prof. P. Zhu as an alternative to the Allen-Cahn model for the description of phase field transformations. With low interfacial energy, it is more efficient, since the resolution of the diffuse interface is numerically broader for the same solution accuracy and allows coarser meshing. The solutions of both models are associated with energy minimisation and in this work the error terms introduced in the earlier publications are discussed and documented using one and two dimensional numerical simulations. In the last part of this book, phase field problems, initially not coupled with material equations, are combined with linear elasticity and, after simple introductory examples, a growing martensitic inclusion is simulated and compared with literature data. In addition to the confirmed numerical advantage, another phenomenon not previously described in the literature is found: with the hybrid model, in contrast to the examples calculated with the Allen-Cahn model, an inclusion driven mainly by curvature energy does not disappear completely. The opposite problem prevents inclusions from growing from very small initial configurations, but this fact can be remedied by a very finely chosen diffuse interface width and by analysing and adjusting the terms that generate the modelling errors. The last example shows that the hybrid model can be used with numerical advantages despite the above mentioned peculiarities.
    Keywords: Science ; Chemistry ; Mathematics ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PN Chemistry ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 9
    Publication Date: 2024-04-04
    Description: Ein zentrales Ziel der fachdidaktischen Forschung stellt die Verbesserung schulischen Unterrichts dar. Eine Transferstrategie zur flächendeckenden Verbreitung wissenschaftlicher Erkenntnisse bildet die Bereitstellung evidenzbasierter, innovativer materialgestützter Unterrichtskonzeptionen. Allerdings fällt das Materialnutzungsverhalten von Lehrkräften individuell sehr unterschiedlich aus, wobei das Zusammenspiel verschiedener Einflussfaktoren auf die Materialnutzung bislang wenig erforscht ist. Ziel der vorliegenden Arbeit ist es daher, dieses Wirkgefüge unter authentischen Bedingungen genauer zu untersuchen. Dazu wurde kriteriengeleitet eine evidenzbasierte, fachdidaktisch innovative Unterrichtskonzeption ausgewählt (das Münchener Unterrichtskonzept zur Quantenmechanik) und den teilnehmenden Lehrkräften fakultativ zur Verfügung gestellt. Mittels eines qualitativen Forschungsansatzes wurden elf Lehrkräfte bei der Implementierung des Konzepts durch ein Interview zu Beginn und am Ende einer Unterrichtsreihe zur Quantenmechanik sowie zwei Unterrichtsbeobachtungen mit je einem anschließenden stimulated recall begleitet. Aus den Ergebnissen folgt, dass die Probanden sich überwiegend heuristisch mit der Konzeption auseinandersetzten und lediglich Elemente auf Sichtstrukturebene implementierten. Das nachgewiesene Wirksamkeitspotential von evidenzbasierten, innovativen Unterrichtskonzeptionen scheint sich folglich lediglich unter bestimmten Bedingungsfaktoren zu entfalten.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 10
    Publication Date: 2023-03-03
    Description: Die vorliegende Dissertation beschreibt den Entwicklungs- und Validierungsprozess eines neuen Testinstruments zur Erfassung von Lehrer-Selbstwirksamkeitserwartungen in vier physikdidaktischen Handlungsfeldern (Umgang mit Aufgaben, Experimentieren, Elementarisieren, Umgang mit Schülervorstellungen), jeweils bezüglich der Dimensionen Planung und Durchführung von Physikunterricht. Die Instrumententwicklung erfolgt in hohem Maße theoriebasiert, indem unter anderem auf der Grundlage der sozial-kognitiven Theorie Banduras Regeln für die Itemkonstruktion abgeleitet werden, die außerdem eine kritische Analyse existierender Instrumente erlauben. Der mehrschrittige Validierungsprozess ist argumentbasiert angelegt. Im Rahmen einer Interviewstudie und einer Expertenbefragung werden vor allem inhaltliche Aspekte, wie z.B. die definitionskonforme Formulierung der Items, die Abdeckung des Handlungsfeldes oder die wahrgenommene Authentizität der Items, untersucht. Im Zuge der auf eine quantitative Auswertung angelegten Hauptstudie (N approx 1000) werden vor allem psychometrische Aspekte, wie die Eindimensionalität der Skalen oder die Passung des Antwortformates, in den Blick genommen. Zusammenfassend kann ein übergeordnetes Validitätsargument in Bezug auf die intendierte Testwertinterpretation formuliert werden. Weiterer Forschungsbedarf deutet sich unter anderem bezüglich der Unterscheidung der zwei genannten Dimensionen an.
    Keywords: Education ; Science ; Physics ; Psychology ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics ; bic Book Industry Communication::J Society & social sciences::JM Psychology
    Language: German
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  • 11
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: In Lehr-Lern-Labor Seminaren können Lehramtsstudierende ihr fachliches, didaktisches und pädagogisches Wissen aufgreifen und in komplexitätsreduzierten Handlungsumgebungen anwenden. Dabei erstellen sie Experimentierstationen, um anschließend in einer iterativen Praxis mehrmals Schülerinnen und Schüler an diesen Stationen zu betreuen. Grundlegend für dieses Vorgehen sind Reflexionsprozesse zwischen den Betreuungen. Inwieweit diese Reflexionsprozesse die Entwicklung der Professionellen Unterrichtswahrnehmung der Studierenden fördern, wurde mit dieser Arbeit untersucht. Als ergänzende Intervention wurden fragenbasierte Videoanalysen der eigenen Betreuungen in das Seminar implementiert. Die Regressionsanalysen zeigten, dass sich die Professionelle Unterrichtswahrnehmung der Studierenden durch die Teilnahme am Seminar verbesserte, wenn zusätzlich das eigene Vorgehen und das ihrer Kommilitonen anhand der erstellten Videos analysiert wurden. Ohne Videoanalyse konnte keine Veränderung festgestellt werden.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 12
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Bei Schülerlaboren als wichtigem Teil außerschulischer MINT-Bildung besteht ein Forschungsdefizit hinsichtlich kognitiver und motivationaler Prozesse auf Seiten der Schülerinnen und Schüler. Mit einem Design-based Research Ansatz klärt die Studie deshalb die Dynamik der Lehr- und Lernprozesse in Schülerlaboren auf und erlaubt es, die Lernangebote mit Blick auf generelle Bildungsziele und spezifische Ziele der Labore empiriebasiert weiterzuentwickeln. Um Angebots-Nutzungs-Prozesse zu untersuchen, wird ein Analyseinstrument entwickelt; es erlaubt gleichermaßen, die didaktische Struktur der Angebote in einer SWOT-Analyse zu erfassen und die ablaufenden Denk- und Lernprozesse der Schülerinnen und Schüler empirisch zu erheben. Das Instrument fokussiert auf drei Dimensionen: die Orientierung der Angebote an Kontexten, die Integration von Problemlöseaufgaben und die Unterstützung von Autonomie der Schülerinnen und Schüler beim Entscheiden und Handeln. Die Ergebnisse der SWOT-Analyse werden mit empirischen Daten, die mit ethnografischen Methoden gewonnen werden, validiert. Eine daraufhin weiterentwickelte didaktische Struktur der Angebote ist hinsichtlich einer differenzierten Kontextualisierung, des Einsatzes narrativer Anker, die Problemlöseaufgaben einleiten, sowie einer phasenweisen Öffnung der Angebote verändert und führt zu besserem Verständnis fachlicher Inhalte und zu einer höheren Motivation.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 13
    Publication Date: 2023-02-01
    Description: Die professionelle Unterrichtswahrnehmung ist eine zentrale und situative Fähigkeit, die (angehende) Lehrkräfte befähigt, Lernprozesse im Unterricht zu erkennen, mithilfe ihres professionellen Wissens zu interpretieren und anschließend lernförderliche Handlungspläne abzuleiten. Der vorliegenden Arbeit liegt die Forschungsfrage zugrunde, ob diese Fähigkeit mit einem physikspezifischen Fokus mithilfe eines Instruments - bestehend aus inszenierten Unterrichtsvideos und einem teilweise geschlossenen Fragebogen - valide erfasst werden kann. Ein solches Instrument könnte dazu dienen, herauszufinden, ob die professionelle Unterrichtswahrnehmung domänenspezifisch ist (Hypothese 1) und ob diese situative Fähigkeit entlang der universitären Ausbildung eine Progression erfährt (Hypothese 2).  Die Ergebnisse der Arbeit ergeben 19 Items (EAP Reliabilität liegt bei 0.698), mit denen eine physikspezifische professionelle Unterrichtswahrnehmung gemessen werden kann. Weitere Analysen (zur Korrelation mit dem physikdidaktischen Wissen und der Abhängigkeit von studiumsbezogenen Daten) stützen die Konstruktvalidität des Tests. In Bezug auf Hypothese 1 hat sich wie erwartet gezeigt, dass die physikspezifische professionelle Unterrichtswahrnehmung signifikant von dem studierten Fach und dem Studiengang abhängt. Anders als erwartet ergeben die Ergebnisse zur Hypothese 2, dass die professionelle Unterrichtswahrnehmung aber nicht signifikant vom Studienfortschritt abhängt.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 14
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: Erkenntnisgewinnung ist in den Naturwissenschaften untrennbar mit wissenschaftlichen Kontroversen verknüpft, die auch für den Physikunterricht einen Bildungswert besitzen, insbesondere im Hinblick auf kritische Urteilsbildung, Multiperspektivität und ein angemessenes Nature-of-Science-Verständnis. Basierend auf einer Charakterisierung wissenschaftlicher Kontroversen wird am Beispiel der Frage nach der Relativität der Masse in der Speziellen Relativitätstheorie in einer explorativ-qualitativen Studie untersucht, wie Physiklehrkräfte und Physiklehramtsstudierende mit einer solchen Kontroverse umgehen und inwieweit sie deren Bildungswert nutzen. Dazu werden sowohl Gedankenauflistungen, die von den Befragten nach dem Lesen von Textmaterialien zu den unterschiedlichen Fachpositionen erstellt wurden, als auch Antworten zu verschiedenen Textvignetten mit Hilfe der qualitativen Inhaltsanalyse ausgewertet. Insgesamt zeigt sich, dass die Studierenden häufiger offen gegenüber den kontroversen fachwissenschaftlichen Positionen sind als die Lehrkräfte. Unterschiede in Bezug auf die Realisierung des Bildungswertes im Unterrichtskontext werden mithilfe von fünf Typen systematisch beschrieben. Ein Großteil der Befragten weist dabei Ansätze zur Umsetzung von Kontroversität im Physikunterricht auf. Die Mehrheit vertritt auch eine eigene fachwissenschaftliche Position und ein Teil der Befragten nutzt die wissenschaftliche Kontroverse zur Thematisierung von Nature-of-Science-Aspekten.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 15
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Fachdidaktisches Wissen gilt als wichtige Gelingensbedingung für einen professionell durchgeführten Unterricht. Positive Selbstwirksamkeitserwartungen, vielfältige Unterrichtskompetenzen sowie eine befürwortende Einstellung gegenüber der Reflexion von Unterricht sind darüber hinaus Indikatoren einer gelingenden Professionalisierung. Professionelle Handlungskompetenz entwickelt sich vornehmlich, wenn angehende Lehrkräfte die Gelegenheit bekommen theoretische Wissensanteile in der Praxis umzusetzen und diesen Transfer zu reflektieren. Die unreflektierte Absolvierung von Unterrichtspraktika birgt nämlich die Gefahr eines "Praxisschocks". Um dem vorzubeugen, ist es förderlich, praktische Studienanteile in ihrer Komplexität sukzessive zu steigern. Es wird davon ausgegangen, dass Lehr-Lern-Labore (LLL) diesen Anforderungen genügen. In der vorliegenden Arbeit wurde die professionalisierende Wirkung dieses Veranstaltungskonzepts am Beispiel des LLL "Schwimmen, Schweben, Sinken" multimethodisch untersucht. Dabei wurden Gruppendiskussionen und Interviews, eine hoch inferente Fremdeinschätzungserhebung sowie eine Prä-Post-Fragebogenstudie mit Studierenden der Bachelorstudiengänge Lehramt Physik sowie Grundschulpädagogik (Sachunterricht) an der Freien Universität Berlin durchgeführt. Die Ergebnisse zeigen, dass Lehr-Lern-Labor-Veranstaltungen einen wichtigen Beitrag zur Anbahnung sowie zur Unterstützung der Professionalisierung von Lehrkräften bereits während des Studiums leisten können, ohne dass es zum "Praxisschock" kommt.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 16
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Eine lernendenorientierte und adaptive Gestaltung von Unterricht erfordert von den Lehrkräften, dass sie vorhandene Kompetenzen und Lernprozesse der Schülerinnen und Schüler diagnostizieren. Außerdem müssen sie die Anforderungen von Aufgaben mit Blick auf deren Passung zu den Lernprozessen der Schülerinnen und Schüler analysieren können. Eine derart verstandene "diagnostische Kompetenz" wird als zentrales Professionalisierungsziel von Lehrkräften angesehen. Vor diesem Hintergrund wurden die diagnostischen Prozesse von acht Studierenden mit den Fächern Physik und Mathematik in zwei aufeinander folgenden Lehrveranstaltungen zur Diagnostik untersucht, um Potentiale und Lernhindernisse im Kompetenzaufbau zu identifizieren. In beiden Veranstaltungen bildeten Vignetten von Lernprozessen den Ausgangspunkt für studentische Diagnosen. Forschungsgegenstand waren u.a. schriftliche Diagnosen der Studierenden im Prä-Post-Vergleich sowie auf Video aufgezeichnete studentische Diskurse bei der Diagnose von Lernprozessen der Schülerinnen und Schüler. Die Analysen erfassen u.a., auf welche Komponenten eines Diagnoseprozesses die Studierenden in welcher Weise Bezug nehmen und welche (fach-) didaktischen überlegungen bzw. Theoriebezüge sie in ihren Diagnosen als Referenzpunkte nutzen. Die Ergebnisse zeigen, dass auf struktureller Ebene zwar alle Komponenten thematisiert, aber inhaltlich nicht entlang einer typischen Abfolge miteinander verbunden werden. Trotz inhaltlicher Prompts wird nur selten explizit auf Theoriebezüge zurückgegriffen.
    Keywords: Mathematics ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: The main focus of this thesis is the discussion of stability of an objective (atomic) structure consisting of single atoms which interact via a potential. We define atomistic stability using a second derivative test. More precisely, atomistic stability is equivalent to a vanishing first derivative of the configurational energy (at the corresponding point) and the coerciveness of the second derivative of the configurational energy with respect to an appropriate semi-norm. Atomistic stability of a lattice is well understood, see, e.,g., [40]. The aim of this thesis is to generalize the theory to objective structures. In particular, we first investigate discrete subgroups of the Euclidean group, then define an appropriate seminorm and the atomistic stability for a given objective structure, and finally provide an efficient algorithm to check its atomistic stability. The algorithm particularly checks the validity of the Cauchy-Born rule for objective structures. To illustrate our results, we prove numerically the stability of a carbon nanotube by applying the algorithm.
    Keywords: Mathematics ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 18
    Publication Date: 2024-04-11
    Description: Die Optimierung dynamischer Dichtsysteme ist eine kostengünstige Methode zur Erhöhung der Wirkungsgrade, Lebensdauer und Betriebssicherheit von Turbomaschinen. Zuverlässige und effiziente Dichtsysteme lassen sich nur realisieren, wenn die Anstreifvorgänge zwischen rotierenden und statischen Komponenten sowie ihre Folgen schon bei der Auslegung berücksichtigt und im Betrieb beherrscht werden können. Bis heute sind die physikalischen Vorgänge beim Anstreifen jedoch nur unzureichend verstanden und es fehlen zuverlässige Modellierungsansätze für ihre Vorhersage. Die vorliegende Arbeit liefert einen essentiellen Beitrag zum Verständnis des Anstreifverhaltens und somit zur Optimierung einlaufender dynamischer Dichtsysteme mit Fokus auf Labyrinthdichtungen mit Einlaufbelägen aus Hohlkörperstrukturen. Mit Hilfe aufwändiger experimenteller Untersuchungen wird in dieser Arbeit ein tiefergreifendes physikalisches Verständnis der Anstreifvorgänge bereitgestellt. Die experimentell gewonnenen Erkenntnisse bilden schließlich die Grundlage für die Entwicklung eines Modellierungsansatzes, der erstmals unter Berücksichtigung aller Einflussparameter die zuverlässige Vorhersage des Anstreifverhaltens einlaufender Labyrinthdichtungen ermöglicht.
    Keywords: Technology & Engineering ; Construction ; Technology & Engineering ; Science ; Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 19
    Publication Date: 2024-04-04
    Description: Formeln sind eine wichtige mathematische Darstellungsform im Physikunterricht. Jedoch haben Lernende häufig Schwierigkeiten bei der Verbalisierung der inhaltlichen Bedeutung von Formeln. Dies wirft die Frage auf, wie Lehrende diese inhaltliche Seite von Formeln vermitteln. Der Theorieteil stellt den Empiriestand zu den Themenkomplexen Formeln und Kommunikation, Alltagssprache, Unterrichts -sprache und Fachsprache im Physikunterricht ausführlich dar. Auf Grundlage sprachwissenschaftlicher Überlegungen wurde ein Ebenenmodell der Versprachlichung von Formeln entwickelt und durch Lehrbuchanalysen validiert, mit dessen Hilfe das Sprechen von und über Formeln analysiert werden kann. In einer qualitativen, explorativ ausgerichteten Feldstudie wurde Physikunterricht von 10 Lehrenden zum elektrischen Widerstand beobachtet und ihre Sprache mit Hilfe der qualitativen Inhaltsanalyse und des entwickelten Ebenenmodells ausgewertet. Das entstandene Kategoriensystem zeigt ein vielfältiges Sprechen über Formeln, das viele Aspekte von Formelverständnis abdeckt. Eine explizite qualitative Interpretation von Formeln bleibt jedoch meist aus. Es zeigt sich in vielen Aspekten ein eher technischer Umgang mit Formeln, der die strukturelle Rolle der Mathematik vernachlässigt. Das Sprechen der Lehrenden im Umgang mit Formeln kann als entweder fachsprachlich, schülernah oder ausgewogen, in einigen Fällen zusätzlich als reflektierend charakterisiert werden.
    Keywords: Mathematics ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 20
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-03-03
    Description: Die fortschreitende Digitalisierung erleichtert den Einsatz von computergestützten Experimentiergelegenheiten in Schule und Universität. Dabei ermöglichen solche Experimente Lernenden eigenständige Erfahrungen mit neuen Fachinhalten. Im Rahmen der vorliegenden Arbeit wurde ein lernerzentriertes und webbasiertes Angebot entwickelt, mit dem Lernende selbstständig Experimente zur Elektronenbewegung in Feldern durchführen können. Dabei wurden verschiedene Möglichkeiten zur Unterstützung der Lernprozesse, die der Einsatz digitaler Endgeräte mit sich bringt, realisiert - dies sind u.a. der Einsatz von Augmented Reality, ergänzenden Visualisierungen und automatisiertem Feedback. Doch über die Häufigkeit und die Art der Nutzung entsprechender Angebote in Schule und beim selbstständigen Lernen gibt es bisher nur wenige empirisch abgesicherte Erkenntnisse. Daher wurde hierzu eine Nutzungsanalyse mithilfe von Usertracking durchgeführt. Diese zeigt, dass das Angebot sowohl im Unterricht als auch beim selbstständigen Lernen sehr häufig genutzt wird, und deckt auf, welche Elemente zu einer intensiven Nutzung des Angebotes führen. Weiter wurde in einer Laborstudie die Wirkung von Multiplen Repräsentationen auf den Erfolg beim experimentellen Hypothesenprüfen und den wahrgenommenen Cognitive Load untersucht. Hier zeigte sich, dass integrierte, dynamisch verlinkte Repräsentationen die Nutzer unterstützen, aber keinen zusätzlichen Cognitive Load verursachen. Dies sollte bei der Gestaltung zukünftiger Angebote berücksichtigt werden.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 21
    Publication Date: 2023-02-01
    Description: Niedrige Studienerfolgsquoten in den Studiengängen Physik und Lehramt Physik sind sowohl aus bildungspolitischer und institutioneller Sicht als auch aus individueller Perspektive erfolglos Studierender eine Herausforderung. Bisher gibt es nur wenige empirische Studien, die Gründe für niedrige Studienerfolgsquoten bestimmen. Von dieser Situation ausgehend, zielte diese Arbeit auf die Erfassung domänenspezifischer Eingangsvoraussetzungen von Studienanfängerinnen und -anfängern, um daraus mögliche Prädiktoren für einen Studienerfolg zu bestimmen. Den Kern der Arbeit bildet die Konzeption und Evaluation eines Testinstruments zu Studieneingangsvoraussetzungen. Das Instrument umfasst einen Vorwissenstest in Mathematik und Physik sowie einen Test zu domänenspezifischen Verhaltensweisen und Einstellungen. Das selbstentwickelte Instrument wurde bei N = 116 Studierenden eingesetzt, um die Prognosekraft der gemessenen Konstrukte auf einen möglichen Studienerfolg zu schätzen. Dabei zeigte sich der Physikteil des Vorwissenstests in Verbindung mit der Hochschulzugangsberechtigungsnote als signifikanter Prädiktor für den Studienerfolg gemessen am Studienverbleib nach drei Semestern. Dieses Ergebnis stellt im Wesentlichen eine Replikation bereits bekannter Erkenntnisse dar. Es konnten erste Hinweise gefunden werden, dass sich lernzielorientierte Einstellungen positiv auf den Studienerfolg auswirken können.
    Keywords: Social Science ; Statistics ; Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 22
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Die Quantenphysik bildet schon heute das Fundament zahlreicher aktueller Technologien. Zukünftige Quantentechnologien, wie Quantencomputer, werden sowohl in der Industrie als auch für die Gesellschaft an Bedeutung gewinnen. In vielen nationalen und internationalen Schulcurricula ist die Quantenphysik als Thema für den Physikunterricht mittlerweile fest verankert. Aber trotz des enormen Bedeutungszuwachses von Quantentechnologien ist der Unterricht zur Quantenphysik an Schulen nach wie vor von semi-klassischen Modellen und quasi-historischen Zugängen geprägt, während moderne Begriffe der Quantenphysik häufig unberücksichtigt bleiben. Die Folge sind oft klassisch-mechanistisch geprägte Vorstellungen Lernender zur Quantenphysik. Hier setzt diese Arbeit an: mit dem Erlanger Unterrichtskonzept zur Quantenoptik wird ein Konzept vorgestellt, mit dem Lernende der gymnasialen Oberstufe Quanteneffekte anhand quantenoptischer Experimente kennen lernen. Konzepte der Quantenoptik, wie die Präparation von Quantenzuständen, die Antikorrelation am Strahlteiler und die Einzelphotoneninterferenz verhelfen Lernenden zu einem modernen Bild über Quantenphysik. Im Rahmen einer summativen Evaluation im Mixed-Methods-Design mit 171 Schülerinnen und Schülern zeigte sich, dass Lernende mit dem Erlanger Unterrichtskonzept zu quantenphysikalisch dominierten Vorstellungen gelangen und verbreitete Lernschwierigkeiten vermieden werden können.
    Keywords: Science ; Science ; Physics ; Technology & Engineering ; Agriculture ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PH Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TV Agriculture and farming
    Language: German
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  • 23
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Sound power describes the emission of sound from sound sources. Despite today's state-of-the art measurement techniques, the current sound power determination methods are restricted due to various limitations. To overcome these limitations, a new sound power determination method is proposed, aiming at the establishment of traceability in airborne sound. This will enable the characterization of a sound source by its free field sound power. The dissertation describes a study on the dissemination process, which will allow the sound power of a device under test located at a real surrounding environment, to be referred to its free field sound power. Apart from the sound power, the corresponding uncertainty may be estimated in a transparent way, where each uncertainty component is provided. The basic tool for the dissemination process is the substitution method using aerodynamic reference sound sources, applied to both sound pressure and sound intensity measurements. Initially, a theoretical investigation deals with the factors that influence the substitution method. Experimental results are then presented based on measurements using a specially designed scanning apparatus. The transition from calibration to in situ conditions and the required correction, due to changes in environmental and operational conditions, is then discussed. In the last section, the sound power level of devices under test is determined along with its related uncertainty, which is further compared to the up-to-date uncertainty values.
    Keywords: Science ; Physics ; bic Book Industry Communication::P Mathematics & science::PH Physics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 24
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-11
    Description: Human sound localization helps to pay attention to spatially separated speakers using interaural level and time differences as well as angle-dependent monaural spectral cues. In a monophonic teleconference, for instance, it is much more difficult to distinguish between different speakers due to missing binaural cues. Spatial positioning of the speakers by means of binaural reproduction methods using head-related transfer functions (HRTFs) enhances speech comprehension. These HRTFs are influenced by the torso, head and ear geometry as they describe the propagation path of the sound from a source to the ear canal entrance. Through this geometry-dependency, the HRTF is directional and subject-dependent. To enable a sufficient reproduction, individual HRTFs should be used. However, it is tremendously difficult to measure these HRTFs. For this reason this thesis proposes approaches to adapt the HRTFs applying individual anthropometric dimensions of a user. Since localization at low frequencies is mainly influenced by the interaural time difference, two models to adapt this difference are developed and compared with existing models. Furthermore, two approaches to adapt the spectral cues at higher frequencies are studied, improved and compared. Although the localization performance with individualized HRTFs is slightly worse than with individual HRTFs, it is nevertheless still better than with non-individual HRTFs, taking into account the measurement effort.
    Keywords: Technology & Engineering ; Electronics ; Science ; Physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 25
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-03-03
    Description: Bedingt durch die zunehmende Heterogenität der Studierendenschaft rücken die Studienschwierigkeiten in der Studieneingangsphase immer mehr in den Fokus naturwissenschaftsdidaktischer Forschungs- und Entwicklungsarbeiten. In den bisherigen Untersuchungen werden die beim Übergang in die Hochschule auftretenden Lern-, Reflexions- und Entscheidungsprozesse allerdings kaum betrachtet. Vor diesem Hintergrund beschreibt die vorliegende Arbeit anhand des Lernzentrums 'Physiktreff' an der Universität Paderborn die evidenzbasierte Entwicklung und Gestaltung geeigneter Unterstützungsmaßnahmen. Das Maßnahmenpaket des universitären Lernzentrums 'Physiktreff' wurde mit einem Design-Based-Research-Ansatz in mehreren Zyklen entwickelt und mithilfe von schriftlichen Fragebogenerhebungen und leitfadengestützten Interviews evaluiert. Die Analyse von Nutzungstypen stellte je nach Typ unterschiedliche Wirkungen des 'Physiktreffs' fest, z.B. zeigt der 'Physiktreff' Wirkungen in transitionsbedingten Krisen und bei der Vorbereitung auf Prüfungen. Außerdem konnte eine zunächst theoretisch begründete Modellierung der Prozesse in der Studieneingangsphase empirisch fundiert werden.
    Keywords: Education ; Science ; Physics ; Psychology ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics ; bic Book Industry Communication::J Society & social sciences::JM Psychology
    Language: German
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  • 26
    Publication Date: 2023-02-02
    Description: Naturwissenschaftliche Grundbildung im Sinne der Scientific Literacy umfasst das Erlernen inhaltlicher Konzepte sowie naturwissenschaftlicher Denk-, Arbeitsu- und Handlungsweisen. Auch in der Sachunterrichtsdidaktik werden entsprechende Ziele formuliert. Fachdidaktische und entwicklungspsychologische Forschungsergebnisse zeigen, dass Grundschulkinder systematische Strategien der Hypothesenprüfung (Variablenisolation und -kontrolle) erlernen können. Dabei scheint die Unterstützungsmaßnahme des Modeling besonders geeignet. In einem Prä-Post-Follow-up-Design mit Baseline wurden unter Kontrolle der Lernvoraussetzungen die Auswirkungen einer Förderung des Verständnisses der Variablenkontrolle im Kontext Magnetismus durch Modeling im Vergleich zu einem am Offenen Experimentieren orientierten Lernsetting auf (1) eigenständiges Bewerten und Entwickeln von Experimenten, (2) Transferfähigkeit, (3) Entwicklung, Durchführung und Bewertung eigener Experimente, (4) Qualität bzgl. des erreichten Niveaus der Experimente und (5) motivationale Schülermerkmale geprüft. Zur differenzierten Erfassung kamen ein Paper-Pencil-Test und ein videographiertes Interview zum Einsatz. Es konnte gezeigt werden, dass (1) beide Gruppen von der Intervention profitierten, die Daten einer Baseline jedoch auf einen Testwiederholungseffekt hindeuteten. Einflüsse der Intervention auf die anderen Bereiche konnten nachgewiesen werden. Eine Förderung durch Modeling wirkte sich auf alle vier genannten Bereiche (2)-(5) positiv aus.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 27
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-14
    Description: The exchange of orbit information is becoming more important in view of the increasing population of objects in space as well as the increase in parties involved in space operations. The aim of this thesis was to investigate how orbit information maintained by a space surveillance system can be provided to its users. Services like collision avoidance require very accurate information, while other services might be less stringent. An approach was studied, which allows to derive orbit and covariance information of predetermined accuracy from a reference orbit. Using Chebyshev polynomials, continuous state vector and covariance matrix information can be provided. The major advantage is that no inter- or extrapolation on the user's side is required. A method to reduce the data amount by interpolating the variance envelope functions was also studied. The proposed method in this thesis gives access to highly accurate information from the catalogue, where this information is required. On the other hand it can also provide less accurate information, where requirements are less restrictive, thereby allowing for a significantly reduced amount of data to be transferred and stored.
    Keywords: Computers ; Computer Science ; Technology & Engineering ; Science ; Physics ; thema EDItEUR::U Computing and Information Technology::UY Computer science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 28
    Publication Date: 2023-02-02
    Description: Für Studiengänge an deutschen Hochschulen wird heute meistens eine Orientierung an Kompetenzen eingefordert. Die zur Messung dieser Kompetenzen nötigen Testinstrumente fehlen aber weitestgehend. Im Kooperationsprojekt "Ko-WADiS", in dem diese Studie angesiedelt war, wurde ein Kompetenztest zur naturwissenschaftlichen Erkenntnisgewinnung entwickelt. Erkenntnisgewinnung wird dabei als ein komplexer Problemlöseprozess im Sinne des Scientific Reasoning angesehen. Auf Grundlage dieser theoretischen Überlegungen wurden zunächst ein Kompetenzmodell adaptiert und Items entwickelt. Für diese Studie wurde der Kompetenztest in einer querschnittlichen Untersuchung bei Studierenden der Physik eingesetzt. Die empirischen Ergebnisse deuten auf die beste Passung eines eindimensionalen Modells hin. Auf Basis dieses Modells wurden weitere Analysen vorgenommen. Hierbei wird deutlich, dass erwartungskonform Masterstudierende einen höheren Kompetenzstand als Bachelorstudierende haben. Gleichzeitig gibt es Evidenz für einen signifikanten Vorteil der Fachstudierenden im Vergleich zu den Lehramtsstudierenden. Keine Vorteile zeigen sich hingegen für Lehramtsstudierende der Physik mit einem weiteren naturwissenschaftlichen Fach.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 29
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-03-03
    Description: Die Einstellung von Lehrkräften bestimmt deren Handeln mit. Die vorliegende Studie befasst sich mit dem Nutzungsverhalten und der Einstellung von Physiklehrkräften bzgl. Computern und Neuen Medien im unterrichtlichen Zusammenhang. Außerdem werden die Einstellung und Einschätzung von Schülerinnen und Schülern zu diesem Thema untersucht. Methodisch wurden dazu sowohl quantitative Analysemethoden auf Basis von Fragebögen, als auch qualitative Methoden wie halboffene Interviews genutzt und kombiniert. Durch die explorative Untersuchung konnte festgestellt werden, dass sich die Einstellung zum Computereinsatz im Physikunterricht in sechs Dimensionen beschreiben lässt, auf deren Basis die Lehrkräfte in fünf Gruppen klassifiziert werden: Verhinderte Nutzer, Neugierige, Computerenthusiasten, Realisten und Meider. Für jede dieser Gruppen lassen sich unterschiedliche Handlungsempfehlungen formulieren, um den Einsatz Neuer Medien bei Physiklehrkräften zu fördern.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 30
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-14
    Description: Orbital debris is becoming an increasing problem for space flight missions. New satellite launches, explosions, collisions and other events cause a steady rise in the number of objects orbiting the Earth. It is therefore important to determine the future development of the object population, as well as the effectiveness of debris mitigation measures, in long-term simulations. Orbital propagation, the calculation of an object's movement in its orbit, poses a challenge for this research due to the high computation times of the complex perturbation models involved. With populations consisting of hundreds of thousands of objects as well as simulation time frames of up to 200 years, these calculations can take up hours of computation time. To speed up this process, the analytical propagator Ikebana is introduced in this work of applied computer science in engineering. The program runs on graphics processing units, hardware designed for massively parallel execution of up to thousands of concurrent threads. This reduces the overall run time for large object populations from hours to minutes. Porting software from a conventional CPU is not a trivial task and involves a number of potential pitfalls and optimization opportunities which are detailed in this work. The propagator is integrated into other applications via a generic, multi-platform interface specifically designed for this task. It allows to develop the propagator separately and integrate it into other tools as a plugin at run time. The interface's architecture serves as a design template for analytical propagation software.
    Keywords: Computers ; Computer Science ; Technology & Engineering ; Science ; Physics ; thema EDItEUR::U Computing and Information Technology::UY Computer science ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 31
    Publication Date: 2023-11-15
    Description: Die Didaktik der Physik ist im deutschsprachigen Raum mittlerweile fest etabliert. Ihre Akteur_innen haben ein Selbstverständnis als eigene wissenschaftliche Disziplin entwickelt, die eigene Forschungsfelder und -fragestellungen in den Fokus nimmt und mit spezifischen Forschungsformaten und -methoden untersucht. Die Forschungsaktivität in dieser Disziplin nimmt seit Jahren stetig zu und differenziert sich inhaltlich immer stärker aus, so dass es in der Didaktik der Physik kaum noch möglich ist, einen Überblick über alle Entwicklungen zu behalten. Zugleich sind die eigenen ideengeschichtlichen Wurzeln dieser Disziplin im aktuellen Forschungsbetrieb nicht mehr sehr präsent. Gerade Nachwuchswissenschaftler_innen sind sie nicht immer bewusst. Als Ergebnis einer über 3 Jahren dauernden Delphi-Studie legen wir in diesem Band eine Sammlung von Verweisen auf grundlegende und wegweisende Literatur der Physikdidaktik vor, die von Expert_innen jeweils kurz in den wissenschaftshistorischen Kontext eingeordnet werden. Es handelt sich hier nicht um ein Lehrbuch, sondern um eine Ressource, die die die historische Vielfalt physikdidaktischer Denk- und Forschungsansätze kompakt zugänglich macht und die zur Reflexion über die Fachdidaktik und ihr Selbstverständnis als wissenschaftliche Disziplin anregen soll. Sie möchte auf sinnvolle und ökonomische Weise die historische »Werdung« der Physikdidaktik nahebringen.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 32
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-02
    Description: Flipped Classroom ist eine innovative Unterrichtsmethode, bei der sich Schülerinnen und Schüler zuhause mit Lernvideos auf den Unterricht vorbereiten. Im Unterricht selbst steht dann die Anwendung und Vertiefung des Wissens in kooperativen Lernsettings im Vordergrund. Wissenschaftlich ist der Einsatz dieser Methode im deutschen Schulunterricht bislang nicht untersucht worden, auch nicht im Physikunterricht. Haben die Schülerinnen und Schüler hier einen höheren Lernzuwachs? Ändern sich das Selbstkonzept, das Fachinteresse und die Motivation? Welche Rolle spielt dabei das Leistungsvermögen oder das Geschlecht? Die vorliegende quasi-experimentelle Interventionsstudie im Pre-/Postdesign mit Kontrollgruppe untersuchte den Einsatz des Flipped Classroom im Physikunterricht. Dabei zeigten sich positive Effekte auf den Lernerfolg sowie teilweise auf affektive Lernmerkmale. Motivational profitierten vor allem die Mädchen vom Flipped Classroom, die Jungen hingegen verbesserten deutlich ihre Hausaufgabendisziplin.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 33
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2023-02-01
    Description: In fachdidaktischen Interventionsstudien wird Unterricht auf Basis neu entwickelter Unterrichtskonzepte öfter mit "traditionellem Unterricht" verglichen. Eine vertiefte Auseinandersetzung mit "traditionellem Unterricht" bei Interventionsstudien ermöglicht einen differenzierteren Blick auf deren Ergebnisse, aber auch ein tieferes Verständnis von Akzeptanzhürden, die bei der Umsetzung neuer Unterrichtskonzepte auftreten können. In dieser Studie wurde daher der Anfangs-Elektrizitäts -lehreunterricht von 32 Lehrkräften in Bayern, Hessen und Österreich beleuchtet: Einerseits wurden Elemente der individuell umgesetzten Sachstruktur der Lehrkräfte mithilfe von Logbüchern und Schülerheften rekonstruiert. Andererseits wurde der Zusammenhang zwischen ausgewählten Lehrkräfte- und Schülervariablen untersucht. Die Ergebnisse zeigen, dass sich für die Auswahl und Abfolge von Fachinhalten und den Einsatz von Analogiemodellen einige Muster identifizieren lassen, denen ein Großteil der Lehrkräfte folgte. Im Zuge von Mehrebenenanalysen konnten die erhobenen Aspekte des Professionswissens der Lehrkräfte in einer Betrachtung des Gesamtsamples der Lernenden nicht als Prädiktor für fachlichen Lernerfolg identifiziert werden, jedoch für das Sub-Sample der Lehrkräfte mit weniger als zehn Dienstjahren. Für die Entwicklung des Fachinteresses und des physikbezogenen Selbstkonzepts der Lernenden stellten sich die epistemologischen Vorstellungen und die Selbstwirksamkeitserwartung der Lehrkräfte im Umgang mit Schülervorstellungen als Prädiktoren heraus.
    Keywords: Education ; Science ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: German
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  • 34
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Eine lernendenorientierte und adaptive Gestaltung von Unterricht erfordert von den Lehrkräften, dass sie vorhandene Kompetenzen und Lernprozesse der Schülerinnen und Schüler diagnostizieren. Außerdem müssen sie die Anforderungen von Aufgaben mit Blick auf deren Passung zu den Lernprozessen der Schülerinnen und Schüler analysieren können. Eine derart verstandene "diagnostische Kompetenz" wird als zentrales Professionalisierungsziel von Lehrkräften angesehen. Vor diesem Hintergrund wurden die diagnostischen Prozesse von acht Studierenden mit den Fächern Physik und Mathematik in zwei aufeinander folgenden Lehrveranstaltungen zur Diagnostik untersucht, um Potentiale und Lernhindernisse im Kompetenzaufbau zu identifizieren. In beiden Veranstaltungen bildeten Vignetten von Lernprozessen den Ausgangspunkt für studentische Diagnosen. Forschungsgegenstand waren u.a. schriftliche Diagnosen der Studierenden im Prä-Post-Vergleich sowie auf Video aufgezeichnete studentische Diskurse bei der Diagnose von Lernprozessen der Schülerinnen und Schüler. Die Analysen erfassen u.a., auf welche Komponenten eines Diagnoseprozesses die Studierenden in welcher Weise Bezug nehmen und welche (fach-) didaktischen überlegungen bzw. Theoriebezüge sie in ihren Diagnosen als Referenzpunkte nutzen. Die Ergebnisse zeigen, dass auf struktureller Ebene zwar alle Komponenten thematisiert, aber inhaltlich nicht entlang einer typischen Abfolge miteinander verbunden werden. Trotz inhaltlicher Prompts wird nur selten explizit auf Theoriebezüge zurückgegriffen.
    Keywords: Mathematics ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 35
    Publication Date: 2024-03-29
    Description: Niedrige Studienerfolgsquoten in den Studiengängen Physik und Lehramt Physik sind sowohl aus bildungspolitischer und institutioneller Sicht als auch aus individueller Perspektive erfolglos Studierender eine Herausforderung. Bisher gibt es nur wenige empirische Studien, die Gründe für niedrige Studienerfolgsquoten bestimmen. Von dieser Situation ausgehend, zielte diese Arbeit auf die Erfassung domänenspezifischer Eingangsvoraussetzungen von Studienanfängerinnen und -anfängern, um daraus mögliche Prädiktoren für einen Studienerfolg zu bestimmen. Den Kern der Arbeit bildet die Konzeption und Evaluation eines Testinstruments zu Studieneingangsvoraussetzungen. Das Instrument umfasst einen Vorwissenstest in Mathematik und Physik sowie einen Test zu domänenspezifischen Verhaltensweisen und Einstellungen. Das selbstentwickelte Instrument wurde bei N = 116 Studierenden eingesetzt, um die Prognosekraft der gemessenen Konstrukte auf einen möglichen Studienerfolg zu schätzen. Dabei zeigte sich der Physikteil des Vorwissenstests in Verbindung mit der Hochschulzugangsberechtigungsnote als signifikanter Prädiktor für den Studienerfolg gemessen am Studienverbleib nach drei Semestern. Dieses Ergebnis stellt im Wesentlichen eine Replikation bereits bekannter Erkenntnisse dar. Es konnten erste Hinweise gefunden werden, dass sich lernzielorientierte Einstellungen positiv auf den Studienerfolg auswirken können.
    Keywords: Social Science ; Statistics ; Education ; Science ; Physics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBC Social research and statistics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 36
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-04
    Description: Die Teilchenphysik als Teilgebiet der modernen Physik gewinnt zunehmend an Bedeutung im schulischen Physikunterricht. In dieser Arbeit wird erstmalig das von Lehrkräften benötigte Fachwissen zur Teilchenphysik modelliert, wobei Fachwissen als ein Teil des Professionswissens verstanden wird. Als Fachwissensdimensionen werden die Inhaltsbereiche und die Wissensarten in den Fokus genommen, für welche jeweils Subfacetten identifiziert und präzise beschrieben werden. Nach einem überblick über die wesentlichen Ideen der Teilchenphysik wird in der Arbeit die sukzessive Modellierung des Fachwissens im Rahmen einer qualitativ und quantitativ angelegten Delphi-Studie vorgestellt. In drei Befragungsrunden wurden zwischen 35 und 65 internationale Expertinnen und Experten aus der teilchenphysikbezogenen Forschung (Fachwissenschaft und Fachdidaktik) und öffentlichkeitsarbeit (u.a. Wissenschaftsjournalismus) sowie erfahrene Lehrkräfte zu den für das Fachwissen relevanten Themen der Teilchenphysik befragt. Empirische Analysen der Befragungsrunden ergaben, dass sich die Dimension Inhaltsbereiche im deklarativen Wissen aus zehn teilchenphysikalischen Themen (z.B. Teilchen in der Hochenergiephysik, die vier fundamentalen Wechselwirkungen) zusammensetzt, von welchen sechs als besonders relevant eingeschätzt wurden. Im Anschluss an die letzte Befragungsrunde wurde theoriegeleitet eine erste Modellierung der Inhaltsbereiche für die Wissensarten des prozeduralen und konditionalen Wissens vorgenommen.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 37
    Publication Date: 2024-04-04
    Description: Ein zentrales Ziel der fachdidaktischen Forschung stellt die Verbesserung schulischen Unterrichts dar. Eine Transferstrategie zur flächendeckenden Verbreitung wissenschaftlicher Erkenntnisse bildet die Bereitstellung evidenzbasierter, innovativer materialgestützter Unterrichtskonzeptionen. Allerdings fällt das Materialnutzungsverhalten von Lehrkräften individuell sehr unterschiedlich aus, wobei das Zusammenspiel verschiedener Einflussfaktoren auf die Materialnutzung bislang wenig erforscht ist. Ziel der vorliegenden Arbeit ist es daher, dieses Wirkgefüge unter authentischen Bedingungen genauer zu untersuchen. Dazu wurde kriteriengeleitet eine evidenzbasierte, fachdidaktisch innovative Unterrichtskonzeption ausgewählt (das Münchener Unterrichtskonzept zur Quantenmechanik) und den teilnehmenden Lehrkräften fakultativ zur Verfügung gestellt. Mittels eines qualitativen Forschungsansatzes wurden elf Lehrkräfte bei der Implementierung des Konzepts durch ein Interview zu Beginn und am Ende einer Unterrichtsreihe zur Quantenmechanik sowie zwei Unterrichtsbeobachtungen mit je einem anschließenden stimulated recall begleitet. Aus den Ergebnissen folgt, dass die Probanden sich überwiegend heuristisch mit der Konzeption auseinandersetzten und lediglich Elemente auf Sichtstrukturebene implementierten. Das nachgewiesene Wirksamkeitspotential von evidenzbasierten, innovativen Unterrichtskonzeptionen scheint sich folglich lediglich unter bestimmten Bedingungsfaktoren zu entfalten.
    Keywords: Science ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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  • 38
    Publication Date: 2016-01-21
    Description: Bacteria express many small RNAs for which the regulatory roles in pathogenesis have remained poorly understood due to a paucity of robust phenotypes in standard virulence assays. Here we use a generic 'dual RNA-seq' approach to profile RNA expression simultaneously in pathogen and host during Salmonella enterica serovar Typhimurium infection and reveal the molecular impact of bacterial riboregulators. We identify a PhoP-activated small RNA, PinT, which upon bacterial internalization temporally controls the expression of both invasion-associated effectors and virulence genes required for intracellular survival. This riboregulatory activity causes pervasive changes in coding and noncoding transcripts of the host. Interspecies correlation analysis links PinT to host cell JAK-STAT signalling, and we identify infection-specific alterations in multiple long noncoding RNAs. Our study provides a paradigm for a sensitive RNA-based analysis of intracellular bacterial pathogens and their hosts without physical separation, as well as a new discovery route for hidden functions of pathogen genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westermann, Alexander J -- Forstner, Konrad U -- Amman, Fabian -- Barquist, Lars -- Chao, Yanjie -- Schulte, Leon N -- Muller, Lydia -- Reinhardt, Richard -- Stadler, Peter F -- Vogel, Jorg -- England -- Nature. 2016 Jan 28;529(7587):496-501. doi: 10.1038/nature16547. Epub 2016 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Wurzburg, RNA Biology Group, Institute for Molecular Infection Biology, Josef-Schneider-Strasse 2/D15, D-97080 Wurzburg, Germany. ; University of Wurzburg, Core Unit Systems Medicine, Josef-Schneider-Strasse 2/D15, D-97080 Wurzburg, Germany. ; University of Leipzig, Department of Computer Science and Interdisciplinary Center for Bioinformatics, Hartelstrasse 16-18, D-04107 Leipzig, Germany. ; University of Vienna, Theoretical Biochemistry Group, Institute for Theoretical Chemistry, Wahringer Strasse 17, A-1090 Vienna, Austria. ; Max Planck Genome Centre Cologne, Max Planck Institute for Plant Breeding Research, Carl-von-Linne-Weg 10, D-50829 Cologne, Germany. ; Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, D-04103 Leipzig, Germany. ; Santa Fe Institute, 1399 Hyde Park Rd, Santa Fe, New Mexico 87501, USA. ; Research Centre for Infectious Diseases (ZINF), University of Wurzburg, D-97070 Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26789254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/metabolism ; Female ; Gene Expression Regulation/*genetics ; Genes, Bacterial/genetics ; HeLa Cells ; Host-Pathogen Interactions/*genetics ; Humans ; Janus Kinases/metabolism ; Mice ; Microbial Viability/genetics ; RNA, Bacterial/*genetics/metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Untranslated/*genetics/metabolism ; STAT Transcription Factors/metabolism ; Salmonella typhimurium/cytology/*genetics/pathogenicity ; Signal Transduction/genetics ; Transcriptome/genetics ; Virulence/genetics
    Print ISSN: 0028-0836
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 39
    Publication Date: 2016-04-29
    Description: The meaning of language is represented in regions of the cerebral cortex collectively known as the 'semantic system'. However, little of the semantic system has been mapped comprehensively, and the semantic selectivity of most regions is unknown. Here we systematically map semantic selectivity across the cortex using voxel-wise modelling of functional MRI (fMRI) data collected while subjects listened to hours of narrative stories. We show that the semantic system is organized into intricate patterns that seem to be consistent across individuals. We then use a novel generative model to create a detailed semantic atlas. Our results suggest that most areas within the semantic system represent information about specific semantic domains, or groups of related concepts, and our atlas shows which domains are represented in each area. This study demonstrates that data-driven methods--commonplace in studies of human neuroanatomy and functional connectivity--provide a powerful and efficient means for mapping functional representations in the brain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852309/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852309/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huth, Alexander G -- de Heer, Wendy A -- Griffiths, Thomas L -- Theunissen, Frederic E -- Gallant, Jack L -- EY019684/EY/NEI NIH HHS/ -- R01 EY019684/EY/NEI NIH HHS/ -- England -- Nature. 2016 Apr 28;532(7600):453-8. doi: 10.1038/nature17637.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. ; Department of Psychology, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27121839" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Perception ; *Brain Mapping ; Cerebral Cortex/*anatomy & histology/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Narration ; Principal Component Analysis ; Reproducibility of Results ; *Semantics ; *Speech
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  • 40
    Publication Date: 2016-03-24
    Description: Developmental disabilities, including attention-deficit hyperactivity disorder (ADHD), intellectual disability (ID), and autism spectrum disorders (ASD), affect one in six children in the USA. Recently, gene mutations in patched domain containing 1 (PTCHD1) have been found in ~1% of patients with ID and ASD. Individuals with PTCHD1 deletion show symptoms of ADHD, sleep disruption, hypotonia, aggression, ASD, and ID. Although PTCHD1 is probably critical for normal development, the connection between its deletion and the ensuing behavioural defects is poorly understood. Here we report that during early post-natal development, mouse Ptchd1 is selectively expressed in the thalamic reticular nucleus (TRN), a group of GABAergic neurons that regulate thalamocortical transmission, sleep rhythms, and attention. Ptchd1 deletion attenuates TRN activity through mechanisms involving small conductance calcium-dependent potassium currents (SK). TRN-restricted deletion of Ptchd1 leads to attention deficits and hyperactivity, both of which are rescued by pharmacological augmentation of SK channel activity. Global Ptchd1 deletion recapitulates learning impairment, hyper-aggression, and motor defects, all of which are insensitive to SK pharmacological targeting and not found in the TRN-restricted deletion mouse. This study maps clinically relevant behavioural phenotypes onto TRN dysfunction in a human disease model, while also identifying molecular and circuit targets for intervention.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875756/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875756/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wells, Michael F -- Wimmer, Ralf D -- Schmitt, L Ian -- Feng, Guoping -- Halassa, Michael M -- F31 MH098641/MH/NIMH NIH HHS/ -- R00 NS078115/NS/NINDS NIH HHS/ -- R01 MH097104/MH/NIMH NIH HHS/ -- R01 MH107680/MH/NIMH NIH HHS/ -- R01MH097104/MH/NIMH NIH HHS/ -- R01MH10768/MH/NIMH NIH HHS/ -- England -- Nature. 2016 Apr 7;532(7597):58-63. doi: 10.1038/nature17427. Epub 2016 Mar 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA. ; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. ; Neuroscience Institute, New York University Langone Medical Center, New York, New York 10016, USA. ; Department of Neuroscience and Physiology, New York University Langone Medical Center, New York, New York 10016, USA. ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA. ; Department of Psychiatry, New York University Langone Medical Center, New York, New York 10016, USA. ; Center for Neural Science, New York University, New York, New York 1003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27007844" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animals ; Animals, Newborn ; Attention ; Attention Deficit Disorder with ; Hyperactivity/genetics/*physiopathology/*psychology ; Behavior, Animal ; Disease Models, Animal ; Electric Conductivity ; Female ; GABAergic Neurons/metabolism/pathology ; *Gene Deletion ; Humans ; Learning Disorders/genetics/physiopathology ; Male ; Membrane Proteins/*deficiency/*genetics/metabolism ; Mice ; Mice, Knockout ; Motor Disorders/genetics/physiopathology ; Neural Inhibition ; Potassium Channels, Calcium-Activated/metabolism ; Sleep ; Sleep Deprivation/genetics/physiopathology ; Thalamic Nuclei/pathology/*physiopathology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 41
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owens, Brian -- England -- Nature. 2016 May 11;533(7602):S71-2. doi: 10.1038/533S71a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27167398" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics ; *Access to Information ; Animals ; *Diffusion of Innovation ; Drug Industry/economics/methods ; Humans ; *Information Dissemination ; Mice ; Neurosciences/economics/manpower/*methods/organization & administration ; Patents as Topic ; Public Sector/economics ; Public-Private Sector Partnerships ; Quebec
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 42
    Publication Date: 2016-01-07
    Description: Endothelial cells (ECs) are plastic cells that can switch between growth states with different bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues, ECs divide and migrate rapidly upon proangiogenic stimulation. Adjusting endothelial metabolism to the growth state is central to normal vessel growth and function, yet it is poorly understood at the molecular level. Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an essential regulator of vascular growth that couples metabolic and proliferative activities in ECs. Endothelial-restricted deletion of FOXO1 in mice induces a profound increase in EC proliferation that interferes with coordinated sprouting, thereby causing hyperplasia and vessel enlargement. Conversely, forced expression of FOXO1 restricts vascular expansion and leads to vessel thinning and hypobranching. We find that FOXO1 acts as a gatekeeper of endothelial quiescence, which decelerates metabolic activity by reducing glycolysis and mitochondrial respiration. Mechanistically, FOXO1 suppresses signalling by MYC (also known as c-MYC), a powerful driver of anabolic metabolism and growth. MYC ablation impairs glycolysis, mitochondrial function and proliferation of ECs while its EC-specific overexpression fuels these processes. Moreover, restoration of MYC signalling in FOXO1-overexpressing endothelium normalizes metabolic activity and branching behaviour. Our findings identify FOXO1 as a critical rheostat of vascular expansion and define the FOXO1-MYC transcriptional network as a novel metabolic checkpoint during endothelial growth and proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilhelm, Kerstin -- Happel, Katharina -- Eelen, Guy -- Schoors, Sandra -- Oellerich, Mark F -- Lim, Radiance -- Zimmermann, Barbara -- Aspalter, Irene M -- Franco, Claudio A -- Boettger, Thomas -- Braun, Thomas -- Fruttiger, Marcus -- Rajewsky, Klaus -- Keller, Charles -- Bruning, Jens C -- Gerhardt, Holger -- Carmeliet, Peter -- Potente, Michael -- K08CA090438/CA/NCI NIH HHS/ -- Cancer Research UK/United Kingdom -- England -- Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498. Epub 2016 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Angiogenesis &Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany. ; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven 3000, Belgium. ; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven 3000, Belgium. ; Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY, UK. ; Vascular Morphogenesis Laboratory, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon 1649-028, Portugal. ; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany. ; UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK. ; Max Delbruck Center for Molecular Medicine (MDC), D-13125 Berlin, Germany. ; Children's Cancer Therapy Development Institute, Beaverton, Oregon 97005, USA. ; Max Planck Institute for Metabolism Research, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University of Cologne, D-50931 Cologne, Germany. ; Vascular Patterning Laboratory, Vesalius Research Center, VIB and University of Leuven, Leuven 3000, Belgium. ; DZHK (German Center for Cardiovascular Research), partner site Berlin, D-13347 Berlin, Germany. ; Berlin Institute of Health (BIH), D-10117 Berlin, Germany. ; International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland. ; DZHK (German Center for Cardiovascular Research), partner site Frankfurt Rhine-Main, D-13347 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26735015" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Proliferation ; Cell Respiration ; Endothelium, Vascular/cytology/*growth & development/*metabolism ; Female ; Forkhead Transcription Factors/deficiency/genetics/*metabolism ; Glycolysis ; Human Umbilical Vein Endothelial Cells/cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/deficiency/genetics/metabolism ; Signal Transduction
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  • 43
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padma, T V -- England -- Nature. 2016 Mar 3;531(7592):16-7. doi: 10.1038/531016a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26935674" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics ; Biotechnology/economics/trends ; *Budgets ; Drug Industry/economics ; *Federal Government ; Genomics/*economics/trends ; Humans ; India ; Precision Medicine/economics ; Research Support as Topic/economics ; Technology Transfer
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  • 44
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willyard, Cassandra -- England -- Nature. 2016 Apr 14;532(7598):166-8. doi: 10.1038/532166a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075079" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/economics/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/economics/*therapeutic use ; Clinical Trials as Topic ; DNA Mutational Analysis ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/*drug effects/genetics ; *Evolution, Molecular ; Female ; Humans ; Immunotherapy, Adoptive/economics/trends ; Mice ; Molecular Targeted Therapy/economics/*methods/trends ; Mutation/*genetics ; Neoplasm Metastasis/drug therapy/genetics/pathology ; Neoplasm Recurrence, Local/chemically induced/genetics/prevention & control ; Neoplasms/*drug therapy/*genetics/pathology ; Selection, Genetic/*drug effects/genetics ; Tumor Microenvironment/drug effects
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  • 45
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cartwright, Jon -- England -- Nature. 2016 Mar 31;531(7596):669-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27035011" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; *Crowdsourcing/instrumentation/methods ; Data Collection/*instrumentation ; Databases, Factual ; Humans ; Mobile Applications/utilization ; Science/*instrumentation/manpower/*methods ; Smartphone/*utilization
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  • 46
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willyard, Cassandra -- England -- Nature. 2016 May 5;533(7601):S43-5. doi: 10.1038/533S43a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27144609" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/*organization & administration ; Developing Countries/economics ; Drug Discovery/*economics/organization & administration ; Drug Industry/economics ; Foundations/economics/organization & administration ; Fund Raising/*economics/*organization & administration ; Global Health/economics ; Humans ; Investments/*economics/*organization & administration ; Vaccines/economics
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  • 47
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2016 Mar 3;531(7592):19. doi: 10.1038/531019a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26935676" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western/epidemiology ; Brazil/epidemiology ; Disease Outbreaks/statistics & numerical data ; *Epidemiological Monitoring ; *Global Health ; Hemorrhagic Fever, Ebola/*epidemiology ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/epidemiology ; Information Dissemination ; Microcephaly/complications/epidemiology ; Public Health ; World Health Organization/*organization & administration ; *Zika Virus ; Zika Virus Infection/*epidemiology/virology
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  • 48
    Publication Date: 2016-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2016 May 11;533(7602):154-5. doi: 10.1038/533154a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27172023" target="_blank"〉PubMed〈/a〉
    Keywords: Cognition ; *Educational Status ; European Continental Ancestry Group/genetics ; Gene-Environment Interaction ; Genetic Markers/genetics ; Genetic Variation/*genetics ; Humans ; Intelligence/genetics ; Multifactorial Inheritance/*genetics ; Socioeconomic Factors ; Students/*psychology
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  • 49
    Publication Date: 2016-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2016 Apr 28;532(7600):424-5. doi: 10.1038/532424a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27121817" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/legislation & jurisprudence/*trends ; *Federal Government ; Financing, Government/economics/legislation & jurisprudence ; Humans ; Immunotherapy/economics ; Information Dissemination ; Leadership ; Neoplasms/economics/genetics/immunology/*therapy ; *Private Sector/economics ; *Public-Private Sector Partnerships/economics ; United States
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  • 50
    Publication Date: 2016-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Check Hayden, Erika -- England -- Nature. 2016 Mar 24;531(7595):422-3. doi: 10.1038/531422a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27008946" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Mobile Applications ; Monitoring, Physiologic/*methods/trends ; *Smartphone ; Telemedicine/*trends
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  • 51
    Publication Date: 2016-01-28
    Description: Adeno-associated virus (AAV) vectors are currently the leading candidates for virus-based gene therapies because of their broad tissue tropism, non-pathogenic nature and low immunogenicity. They have been successfully used in clinical trials to treat hereditary diseases such as haemophilia B (ref. 2), and have been approved for treatment of lipoprotein lipase deficiency in Europe. Considerable efforts have been made to engineer AAV variants with novel and biomedically valuable cell tropisms to allow efficacious systemic administration, yet basic aspects of AAV cellular entry are still poorly understood. In particular, the protein receptor(s) required for AAV entry after cell attachment remains unknown. Here we use an unbiased genetic screen to identify proteins essential for AAV serotype 2 (AAV2) infection in a haploid human cell line. The most significantly enriched gene of the screen encodes a previously uncharacterized type I transmembrane protein, KIAA0319L (denoted hereafter as AAV receptor (AAVR)). We characterize AAVR as a protein capable of rapid endocytosis from the plasma membrane and trafficking to the trans-Golgi network. We show that AAVR directly binds to AAV2 particles, and that anti-AAVR antibodies efficiently block AAV2 infection. Moreover, genetic ablation of AAVR renders a wide range of mammalian cell types highly resistant to AAV2 infection. Notably, AAVR serves as a critical host factor for all tested AAV serotypes. The importance of AAVR for in vivo gene delivery is further highlighted by the robust resistance of Aavr(-/-) (also known as Au040320(-/-) and Kiaa0319l(-/-)) mice to AAV infection. Collectively, our data indicate that AAVR is a universal receptor involved in AAV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pillay, S -- Meyer, N L -- Puschnik, A S -- Davulcu, O -- Diep, J -- Ishikawa, Y -- Jae, L T -- Wosen, J E -- Nagamine, C M -- Chapman, M S -- Carette, J E -- DP2 AI104557/AI/NIAID NIH HHS/ -- R01 GM066875/GM/NIGMS NIH HHS/ -- U19 AI109662/AI/NIAID NIH HHS/ -- England -- Nature. 2016 Feb 4;530(7588):108-12. doi: 10.1038/nature16465. Epub 2016 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, USA. ; Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health &Science University, 3181 Sam Jackson Park Road, Portland, Oregon 97239-3098, USA. ; Shriners Hospital for Children, 3101 Sam Jackson Park Road, Portland, Oregon 97239, USA. ; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. ; Department of Comparative Medicine, Stanford University School of Medicine, 287 Campus Drive, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26814968" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology/pharmacology ; Cell Line ; Dependovirus/classification/drug effects/*physiology ; Endocytosis/drug effects ; Female ; Gene Deletion ; Genetic Therapy/methods ; Host Specificity ; Humans ; Male ; Mice ; Parvoviridae Infections/*metabolism/*virology ; Receptors, Cell Surface/antagonists & inhibitors/deficiency/genetics/*metabolism ; Receptors, Virus/antagonists & inhibitors/deficiency/genetics/*metabolism ; *Viral Tropism/drug effects ; Virus Internalization/drug effects ; trans-Golgi Network/drug effects
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  • 52
    Publication Date: 2016-02-13
    Description: The palaeobiological record of 12 million to 7 million years ago (Ma) is crucial to the elucidation of African ape and human origins, but few fossil assemblages of this period have been reported from sub-Saharan Africa. Since the 1970s, the Chorora Formation, Ethiopia, has been widely considered to contain ~10.5 million year (Myr) old mammalian fossils. More recently, Chororapithecus abyssinicus, a probable primitive member of the gorilla clade, was discovered from the formation. Here we report new field observations and geochemical, magnetostratigraphic and radioisotopic results that securely place the Chorora Formation sediments to between ~9 and ~7 Ma. The C. abyssinicus fossils are ~8.0 Myr old, forming a revised age constraint of the human-gorilla split. Other Chorora fossils range in age from ~8.5 to 7 Ma and comprise the first sub-Saharan mammalian assemblage that spans this period. These fossils suggest indigenous African evolution of multiple mammalian lineages/groups between 10 and 7 Ma, including a possible ancestral-descendent relationship between the ~9.8 Myr old Nakalipithecus nakayamai and C. abyssinicus. The new chronology and fossils suggest that faunal provinciality between eastern Africa and Eurasia had intensified by ~9 Ma, with decreased faunal interchange thereafter. The Chorora evidence supports the hypothesis of in situ African evolution of the Gorilla-Pan-human clade, and is concordant with the deeper divergence estimates of humans and great apes based on lower mutation rates of ~0.5 x 10(-9) per site per year (refs 13 - 15).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Katoh, Shigehiro -- Beyene, Yonas -- Itaya, Tetsumaru -- Hyodo, Hironobu -- Hyodo, Masayuki -- Yagi, Koshi -- Gouzu, Chitaro -- WoldeGabriel, Giday -- Hart, William K -- Ambrose, Stanley H -- Nakaya, Hideo -- Bernor, Raymond L -- Boisserie, Jean-Renaud -- Bibi, Faysal -- Saegusa, Haruo -- Sasaki, Tomohiko -- Sano, Katsuhiro -- Asfaw, Berhane -- Suwa, Gen -- England -- Nature. 2016 Feb 11;530(7589):215-8. doi: 10.1038/nature16510.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Natural History, Hyogo Museum of Nature and Human Activities, Sanda 669-1546, Japan. ; Association for Conservation of Culture Awassa, PO Box 6686, Addis Ababa, Ethiopia. ; Centre francais des etudes ethiopiennes (CFEE), USR CNRS 3137, French Ministry for Foreign Affairs, PO Box 5554, Addis Ababa, Ethiopia. ; Research Institute of Natural Sciences, Okayama University of Science, Okayama 700-0005, Japan. ; Research Center for Inland Seas, Kobe University, Kobe 657-8501, Japan. ; Hiruzen Institute for Geology and Chronology, Okayama 703-8252, Japan. ; EES-14/MS D462, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. ; Department of Geology and Environmental Earth Science, Miami University, 133 Culler Hall, Oxford, Ohio 45056, USA. ; Department of Anthropology, University of Illinois, Urbana, Illinois 61801, USA. ; Department of Earth and Environmental Sciences, Kagoshima University, Kagoshima 890-0065, Japan. ; Department of Anatomy, Howard University, Washington DC 20059, USA. ; Institut de Paleoprimatologie, Paleontologie Humaine : Evolution et Paleoenvironnements (IPHEP), UMR CNRS 7262, Universite de Poitiers, 86022 Poitiers, France. ; Museum fur Naturkunde - Leibniz Institute for Evolution and Biodiversity Science, Invalidenstrasse 43, 10115 Berlin, Germany. ; Institute of Natural and Environmental Sciences, University of Hyogo, Sanda 669-1546, Japan. ; The University Museum, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ; Rift Valley Research Service, PO Box 5717, Addis Ababa, Ethiopia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26863981" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ethiopia ; *Fossils ; Geologic Sediments/chemistry ; *Gorilla gorilla/genetics ; Humans ; Mutation Rate ; *Phylogeny ; *Radiometric Dating ; Time Factors
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  • 53
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bender, Eric -- England -- Nature. 2016 May 11;533(7602):S59. doi: 10.1038/533S59a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27167392" target="_blank"〉PubMed〈/a〉
    Keywords: Diffusion of Innovation ; Drug Discovery/*economics/*methods/organization & administration/trends ; Drug Industry/economics/*methods/organization & administration/*trends ; Humans ; Leadership ; Patient Advocacy
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  • 54
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bender, Eric -- England -- Nature. 2016 May 11;533(7602):S62-4. doi: 10.1038/533S62a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27167394" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amyotrophic Lateral Sclerosis/diagnosis ; *Awards and Prizes ; Biomedical Research/economics/*manpower/*methods ; Breast Neoplasms/diagnosis/pathology ; *Competitive Behavior ; Cooperative Behavior ; Crowdsourcing/economics/*methods ; Datasets as Topic ; Drug Industry/economics/methods ; Humans ; Information Dissemination ; *Interdisciplinary Communication ; Internet/utilization ; Male ; Models, Biological ; Monitoring, Physiologic/instrumentation ; Prognosis ; Reproducibility of Results ; Smartphone/utilization ; Statistics as Topic ; Systems Biology/manpower/methods ; Time Factors
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  • 55
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollock, Kevin -- England -- Nature. 2016 Mar 17;531(7594):S64-6. doi: 10.1038/531S64a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26981733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cities ; *City Planning ; Feedback ; Humans ; *Physics ; Plague/epidemiology ; Rats ; *Urbanization ; Vietnam/epidemiology
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  • 56
    Publication Date: 2016-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cherp, Aleh -- Jewell, Jessica -- England -- Nature. 2016 May 5;533(7601):36. doi: 10.1038/533036b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Central European University, Budapest, Hungary. ; International Institute for Applied Systems Analysis, Laxenburg, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27147023" target="_blank"〉PubMed〈/a〉
    Keywords: *Fukushima Nuclear Accident ; Humans ; Research/*trends
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  • 57
    Publication Date: 2016-01-21
    Description: RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy analysis of human Pol II and its complexes with various proteins. Here we report the 3.4 A resolution cryo-electron microscopy structure of mammalian Pol II in the form of a transcribing complex comprising DNA template and RNA transcript. We use bovine Pol II, which is identical to the human enzyme except for seven amino-acid residues. The obtained atomic model closely resembles its yeast counterpart, but also reveals unknown features. Binding of nucleic acids to the polymerase involves 'induced fit' of the mobile Pol II clamp and active centre region. DNA downstream of the transcription bubble contacts a conserved 'TPSA motif' in the jaw domain of the Pol II subunit RPB5, an interaction that is apparently already established during transcription initiation. Upstream DNA emanates from the active centre cleft at an angle of approximately 105 degrees with respect to downstream DNA. This position of upstream DNA allows for binding of the general transcription elongation factor DSIF (SPT4-SPT5) that we localize over the active centre cleft in a conserved position on the clamp domain of Pol II. Our results define the structure of mammalian Pol II in its functional state, indicate that previous crystallographic analysis of yeast Pol II is relevant for understanding gene transcription in all eukaryotes, and provide a starting point for a mechanistic analysis of human transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernecky, Carrie -- Herzog, Franz -- Baumeister, Wolfgang -- Plitzko, Jurgen M -- Cramer, Patrick -- England -- Nature. 2016 Jan 28;529(7587):551-4. doi: 10.1038/nature16482. Epub 2016 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Gottingen, Germany. ; Gene Center Munich, Ludwig-Maximilians-Universitat Munchen, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. ; Max Planck Institute for Biochemistry, Department of Molecular Structural Biology, Am Klopferspitz 18, 82152 Martinsried, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26789250" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Amino Acid Motifs ; Animals ; Catalytic Domain ; Cattle ; *Cryoelectron Microscopy ; DNA/genetics/metabolism/ultrastructure ; Humans ; Models, Molecular ; Nucleic Acids/chemistry/metabolism ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; RNA Polymerase II/chemistry/*metabolism/*ultrastructure ; RNA, Messenger/biosynthesis/genetics/ultrastructure ; Saccharomyces cerevisiae/enzymology ; Templates, Genetic ; *Transcription Elongation, Genetic
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  • 58
    Publication Date: 2016-01-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Betsholtz, Christer -- England -- Nature. 2016 Jan 14;529(7585):160-1. doi: 10.1038/nature16866. Epub 2016 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Genetics and Pathology at Uppsala University, and the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26735011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endothelium, Vascular/*growth & development/*metabolism ; Female ; Forkhead Transcription Factors/*metabolism ; Humans ; Male
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  • 59
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, Natasha -- England -- Nature. 2016 Mar 17;531(7594):S56-7. doi: 10.1038/531S56a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26981729" target="_blank"〉PubMed〈/a〉
    Keywords: *Affect ; Health Behavior ; Humans ; Mental Health/*statistics & numerical data ; *Nature ; Parks, Recreational/*statistics & numerical data ; Urban Population
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  • 60
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGilvray, Annabel -- England -- Nature. 2016 Mar 3;531(7592):S4-5. doi: 10.1038/531S4a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934524" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates/pharmacology/therapeutic use ; Aging/blood/drug effects/pathology/*psychology ; Alzheimer Disease/blood/therapy ; Animals ; Anti-Asthmatic Agents/pharmacology/therapeutic use ; Cognition Disorders/pathology/physiopathology/*prevention & control/*therapy ; Estrogens/pharmacology ; Female ; Hippocampus/drug effects/pathology/physiology/physiopathology ; Humans ; Inflammation Mediators/immunology ; Leukotrienes/immunology ; Macaca mulatta ; Male ; Mice ; Neuronal Plasticity/drug effects ; Parkinson Disease/therapy ; Plasma/chemistry/physiology ; Prefrontal Cortex/drug effects/pathology/physiology/physiopathology ; Quinolines/pharmacology/therapeutic use ; Rats ; Rejuvenation/*physiology/*psychology ; Synapses/drug effects/metabolism/pathology
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  • 61
    Publication Date: 2016-04-21
    Description: Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immune system, which may account for failures to translate disease treatments from bench to bedside. Laboratory mice live in abnormally hygienic specific pathogen free (SPF) barrier facilities. Here we show that standard laboratory mouse husbandry has profound effects on the immune system and that environmental changes produce mice with immune systems closer to those of adult humans. Laboratory mice--like newborn, but not adult, humans--lack effector-differentiated and mucosally distributed memory T cells. These cell populations were present in free-living barn populations of feral mice and pet store mice with diverse microbial experience, and were induced in laboratory mice after co-housing with pet store mice, suggesting that the environment is involved in the induction of these cells. Altering the living conditions of mice profoundly affected the cellular composition of the innate and adaptive immune systems, resulted in global changes in blood cell gene expression to patterns that more closely reflected the immune signatures of adult humans rather than neonates, altered resistance to infection, and influenced T-cell differentiation in response to a de novo viral infection. These data highlight the effects of environment on the basal immune state and response to infection and suggest that restoring physiological microbial exposure in laboratory mice could provide a relevant tool for modelling immunological events in free-living organisms, including humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871315/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871315/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beura, Lalit K -- Hamilton, Sara E -- Bi, Kevin -- Schenkel, Jason M -- Odumade, Oludare A -- Casey, Kerry A -- Thompson, Emily A -- Fraser, Kathryn A -- Rosato, Pamela C -- Filali-Mouhim, Ali -- Sekaly, Rafick P -- Jenkins, Marc K -- Vezys, Vaiva -- Haining, W Nicholas -- Jameson, Stephen C -- Masopust, David -- 1R01AI111671/AI/NIAID NIH HHS/ -- R01 AI075168/AI/NIAID NIH HHS/ -- R01 AI084913/AI/NIAID NIH HHS/ -- R01 AI111671/AI/NIAID NIH HHS/ -- R01 AI116678/AI/NIAID NIH HHS/ -- R01AI075168/AI/NIAID NIH HHS/ -- R01AI084913/AI/NIAID NIH HHS/ -- R01AI116678/AI/NIAID NIH HHS/ -- England -- Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55414, USA. ; Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55414, USA. ; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital, Boston, Massachusetts 02115, USA. ; Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27096360" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animal Husbandry/*methods ; Animals ; Animals, Laboratory/*immunology ; Animals, Wild/*immunology ; Cell Differentiation ; *Environment ; Environmental Exposure ; Female ; Humans ; Immune System/*immunology ; Immunity/*immunology ; Immunity, Innate/immunology ; Immunologic Memory ; Infant, Newborn ; Male ; Mice ; *Models, Animal ; Phenotype ; Specific Pathogen-Free Organisms ; T-Lymphocytes/cytology/immunology ; Virus Diseases/immunology/virology
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  • 62
    Publication Date: 2016-03-05
    Description: Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5(+) intestinal stem cells of the mammalian intestine. Mechanistically, a HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-delta) signature in intestinal stem cells and progenitor cells (non-intestinal stem cells), and pharmacological activation of PPAR-delta recapitulates the effects of a HFD on these cells. Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituents of the HFD enhances the self-renewal potential of these organoid bodies in a PPAR-delta-dependent manner. Notably, HFD- and agonist-activated PPAR-delta signalling endow organoid-initiating capacity to progenitors, and enforced PPAR-delta signalling permits these progenitors to form in vivo tumours after loss of the tumour suppressor Apc. These findings highlight how diet-modulated PPAR-delta activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846772/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846772/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beyaz, Semir -- Mana, Miyeko D -- Roper, Jatin -- Kedrin, Dmitriy -- Saadatpour, Assieh -- Hong, Sue-Jean -- Bauer-Rowe, Khristian E -- Xifaras, Michael E -- Akkad, Adam -- Arias, Erika -- Pinello, Luca -- Katz, Yarden -- Shinagare, Shweta -- Abu-Remaileh, Monther -- Mihaylova, Maria M -- Lamming, Dudley W -- Dogum, Rizkullah -- Guo, Guoji -- Bell, George W -- Selig, Martin -- Nielsen, G Petur -- Gupta, Nitin -- Ferrone, Cristina R -- Deshpande, Vikram -- Yuan, Guo-Cheng -- Orkin, Stuart H -- Sabatini, David M -- Yilmaz, Omer H -- AI47389/AI/NIAID NIH HHS/ -- DK043351/DK/NIDDK NIH HHS/ -- K08 CA198002/CA/NCI NIH HHS/ -- K99 AG041765/AG/NIA NIH HHS/ -- K99 AG045144/AG/NIA NIH HHS/ -- P30 CA014051/CA/NCI NIH HHS/ -- P30-CA14051/CA/NCI NIH HHS/ -- R00 AG041765/AG/NIA NIH HHS/ -- R00 AG045144/AG/NIA NIH HHS/ -- R01 AI047389/AI/NIAID NIH HHS/ -- R01 CA103866/CA/NCI NIH HHS/ -- R01 CA129105/CA/NCI NIH HHS/ -- R37 AI047389/AI/NIAID NIH HHS/ -- T32DK007191/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, Massachusetts 02139, USA. ; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Division of Gastroenterology and Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA. ; Departments of Pathology, Gastroenterology, and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. ; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA. ; Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, Massachusetts 02142, USA. ; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA. ; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. ; Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Missisippi 39216, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26935695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Count ; Cell Self Renewal/drug effects ; Cell Transformation, Neoplastic/*drug effects ; Colonic Neoplasms/*pathology ; Diet, High-Fat/*adverse effects ; Female ; Genes, APC ; Humans ; Intestines/*pathology ; Male ; Mice ; Obesity/chemically induced/pathology ; Organoids/drug effects/metabolism/pathology ; PPAR delta/metabolism ; Signal Transduction/drug effects ; Stem Cell Niche/drug effects ; Stem Cells/*drug effects/metabolism/*pathology ; beta Catenin/metabolism
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  • 63
    Publication Date: 2016-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinlay, Roger -- England -- Nature. 2016 Mar 31;531(7596):573-5. doi: 10.1038/531573a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Royal Institute of Navigation, and a former head of engineering at Thales UK. He sits on the EPSRC Quantum Technology Strategic Advisory Board.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27029262" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cues ; Facility Design and Construction ; Geographic Information Systems/instrumentation/*utilization ; Hippocampus/anatomy & histology/physiology ; Humans ; Maps as Topic ; Orientation/physiology ; Satellite Communications/utilization ; Smartphone/utilization ; Spatial Learning/*physiology ; Spatial Memory/physiology ; Spatial Navigation/*physiology
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  • 64
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldacre, Ben -- England -- Nature. 2016 Feb 4;530(7588):7. doi: 10.1038/530007a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842021" target="_blank"〉PubMed〈/a〉
    Keywords: Bias (Epidemiology) ; Clinical Trials as Topic/*methods/*standards ; *Editorial Policies ; Evidence-Based Medicine/methods/standards ; Guidelines as Topic ; Humans ; Periodicals as Topic/*standards ; Reproducibility of Results ; Research Report/*standards ; Treatment Outcome
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  • 65
    Publication Date: 2016-04-07
    Description: As the last habitable continent colonized by humans, the site of multiple domestication hotspots, and the location of the largest Pleistocene megafaunal extinction, South America is central to human prehistory. Yet remarkably little is known about human population dynamics during colonization, subsequent expansions, and domestication. Here we reconstruct the spatiotemporal patterns of human population growth in South America using a newly aggregated database of 1,147 archaeological sites and 5,464 calibrated radiocarbon dates spanning fourteen thousand to two thousand years ago (ka). We demonstrate that, rather than a steady exponential expansion, the demographic history of South Americans is characterized by two distinct phases. First, humans spread rapidly throughout the continent, but remained at low population sizes for 8,000 years, including a 4,000-year period of 'boom-and-bust' oscillations with no net growth. Supplementation of hunting with domesticated crops and animals had a minimal impact on population carrying capacity. Only with widespread sedentism, beginning ~5 ka, did a second demographic phase begin, with evidence for exponential population growth in cultural hotspots, characteristic of the Neolithic transition worldwide. The unique extent of humanity's ability to modify its environment to markedly increase carrying capacity in South America is therefore an unexpectedly recent phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, Amy -- Mychajliw, Alexis M -- Hadly, Elizabeth A -- England -- Nature. 2016 Apr 14;532(7598):232-5. doi: 10.1038/nature17176. Epub 2016 Apr 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, Stanford University, Stanford, California 94305, USA. ; Woods Institute, Stanford University, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27049941" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/history ; Archaeology ; Climate ; Geographic Mapping ; History, Ancient ; Human Migration/*history ; Humans ; Population Dynamics/*history ; Radiometric Dating ; Siberia/ethnology ; South America
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  • 66
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Melott, Adrian L -- England -- Nature. 2016 Apr 7;532(7597):40-1. doi: 10.1038/532040a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas 66045, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27078562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Climate Change/history ; *Earth (Planet) ; Extinction, Biological ; Geologic Sediments/chemistry ; History, Ancient ; Humans ; Iron Radioisotopes/*analysis/chemistry ; Stars, Celestial/*chemistry ; Time Factors
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  • 67
    Publication Date: 2016-02-11
    Description: Since the origins of agriculture, the scale of human cooperation and societal complexity has dramatically expanded. This fact challenges standard evolutionary explanations of prosociality because well-studied mechanisms of cooperation based on genetic relatedness, reciprocity and partner choice falter as people increasingly engage in fleeting transactions with genetically unrelated strangers in large anonymous groups. To explain this rapid expansion of prosociality, researchers have proposed several mechanisms. Here we focus on one key hypothesis: cognitive representations of gods as increasingly knowledgeable and punitive, and who sanction violators of interpersonal social norms, foster and sustain the expansion of cooperation, trust and fairness towards co-religionist strangers. We tested this hypothesis using extensive ethnographic interviews and two behavioural games designed to measure impartial rule-following among people (n = 591, observations = 35,400) from eight diverse communities from around the world: (1) inland Tanna, Vanuatu; (2) coastal Tanna, Vanuatu; (3) Yasawa, Fiji; (4) Lovu, Fiji; (5) Pesqueiro, Brazil; (6) Pointe aux Piments, Mauritius; (7) the Tyva Republic (Siberia), Russia; and (8) Hadzaland, Tanzania. Participants reported adherence to a wide array of world religious traditions including Christianity, Hinduism and Buddhism, as well as notably diverse local traditions, including animism and ancestor worship. Holding a range of relevant variables constant, the higher participants rated their moralistic gods as punitive and knowledgeable about human thoughts and actions, the more coins they allocated to geographically distant co-religionist strangers relative to both themselves and local co-religionists. Our results support the hypothesis that beliefs in moralistic, punitive and knowing gods increase impartial behaviour towards distant co-religionists, and therefore can contribute to the expansion of prosociality.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Purzycki, Benjamin Grant -- Apicella, Coren -- Atkinson, Quentin D -- Cohen, Emma -- McNamara, Rita Anne -- Willard, Aiyana K -- Xygalatas, Dimitris -- Norenzayan, Ara -- Henrich, Joseph -- England -- Nature. 2016 Feb 18;530(7590):327-30. doi: 10.1038/nature16980. Epub 2016 Feb 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Human Evolution, Cognition, and Culture, University of British Columbia, 1871 West Mall, Vancouver, British Columbia V6T 1Z2, Canada. ; Department of Psychology, University of Pennsylvania, Solomon Laboratories, 3720 Walnut Street, Philadelphia, Pennsylvania 19104-6241, USA. ; Department of Psychology, University of Auckland, Human Sciences Building, 10 Symonds Street, Auckland 1010, New Zealand. ; Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, D-07745 Jena, Germany. ; Institute of Cognitive and Evolutionary Anthropology, University of Oxford, 64 Banbury Road, Oxford OX2 6PN, UK. ; Wadham College, University of Oxford, Parks Road, Oxford, OX1 3PN, UK. ; Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia V6T 1Z4, Canada. ; Culture, and Development Laboratory, Department of Psychology, The University of Texas at Austin, 1 University Station #A8000, Austin, Texas 78712-0187, USA. ; Department of Anthropology, University of Connecticut, 354 Mansfield Road, Unit 1176, Storrs, Connecticut 06029, USA. ; Interacting Minds Centre, Aarhus University, Jens Chr. Skous Vej 4, building 1483, DK-8000, Aarhus, Denmark. ; LEVYNA, Masaryk University, Brno 60200, Czech Republic. ; Department of Economics, University of British Columbia, 2136 West Mall, Vancouver, British Columbia V6T 1Z4, Canada. ; Department of Human Evolutionary Biology, Harvard University, 11 Divinity Ave, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26863190" target="_blank"〉PubMed〈/a〉
    Keywords: Altruism ; *Cooperative Behavior ; Ethnic Groups/psychology ; Female ; Games, Experimental ; Humans ; Internationality ; *Interpersonal Relations ; Interviews as Topic ; Logistic Models ; Male ; *Morals ; Odds Ratio ; Punishment/*psychology ; Random Allocation ; *Religion and Psychology ; Trust
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  • 68
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grayson, Michelle -- England -- Nature. 2016 Mar 3;531(7592):S1. doi: 10.1038/531S1a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934517" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Asthma/drug therapy ; Cognition/*physiology ; Cognition Disorders/prevention & control/therapy ; Humans ; Interpersonal Relations ; Meta-Analysis as Topic ; Transcranial Direct Current Stimulation
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  • 69
    Publication Date: 2016-03-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bolkan, Scott -- Gordon, Joshua A -- England -- Nature. 2016 Apr 7;532(7597):45-6. doi: 10.1038/nature17311. Epub 2016 Mar 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Columbia University, New York, New York 10032, USA. ; Department of Psychiatry, Columbia University.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27007842" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention Deficit Disorder with Hyperactivity/*physiopathology/*psychology ; Female ; *Gene Deletion ; Humans ; Male ; Membrane Proteins/*deficiency/*genetics ; Thalamic Nuclei/*physiopathology
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  • 70
    Publication Date: 2016-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tracy, Cameron L -- Dustin, Megan K -- Ewing, Rodney C -- England -- Nature. 2016 Jan 14;529(7585):149-51. doi: 10.1038/529149a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for International Security and Cooperation, Stanford University, California, USA. ; Department of Geological Sciences, Stanford University, California, USA. ; Frank Stanton professor in nuclear security at the Center for International Security and Cooperation, Stanford University, California, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26762442" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; New Mexico ; Plutonium/adverse effects ; *Policy Making ; Radioactive Hazard Release/prevention & control/statistics & numerical data ; *Radioactive Waste/adverse effects ; Risk Assessment ; *Safety/statistics & numerical data
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  • 71
    Publication Date: 2016-03-17
    Description: The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) affects 3% of all hospitalized patients. Here we show that the mitochondrial biogenesis regulator, PGC1alpha, is a pivotal determinant of renal recovery from injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis. Following renal ischaemia, Pgc1alpha(-/-) (also known as Ppargc1a(-/-)) mice develop local deficiency of the NAD precursor niacinamide (NAM, also known as nicotinamide), marked fat accumulation, and failure to re-establish normal function. Notably, exogenous NAM improves local NAD levels, fat accumulation, and renal function in post-ischaemic Pgc1alpha(-/-) mice. Inducible tubular transgenic mice (iNephPGC1alpha) recapitulate the effects of NAM supplementation, including more local NAD and less fat accumulation with better renal function after ischaemia. PGC1alpha coordinately upregulates the enzymes that synthesize NAD de novo from amino acids whereas PGC1alpha deficiency or AKI attenuates the de novo pathway. NAM enhances NAD via the enzyme NAMPT and augments production of the fat breakdown product beta-hydroxybutyrate, leading to increased production of prostaglandin PGE2 (ref. 5), a secreted autacoid that maintains renal function. NAM treatment reverses established ischaemic AKI and also prevented AKI in an unrelated toxic model. Inhibition of beta-hydroxybutyrate signalling or prostaglandin production similarly abolishes PGC1alpha-dependent renoprotection. Given the importance of mitochondrial health in ageing and the function of metabolically active organs, the results implicate NAM and NAD as key effectors for achieving PGC1alpha-dependent stress resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tran, Mei T -- Zsengeller, Zsuzsanna K -- Berg, Anders H -- Khankin, Eliyahu V -- Bhasin, Manoj K -- Kim, Wondong -- Clish, Clary B -- Stillman, Isaac E -- Karumanchi, S Ananth -- Rhee, Eugene P -- Parikh, Samir M -- K08-DK090142/DK/NIDDK NIH HHS/ -- K08-DK101560/DK/NIDDK NIH HHS/ -- P30-DK079337/DK/NIDDK NIH HHS/ -- R01 DK095072/DK/NIDDK NIH HHS/ -- R01-DK095072/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2016 Mar 24;531(7595):528-32. doi: 10.1038/nature17184. Epub 2016 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ; Division of Clinical Chemistry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ; Bioinformatics and Systems Biology Core, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ; Nephrology and Endocrine Divisions, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA. ; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26982719" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Hydroxybutyric Acid/metabolism ; Acute Kidney Injury/drug therapy/*metabolism ; Adipose Tissue/drug effects/metabolism ; Amino Acids/metabolism ; Animals ; Cytokines/metabolism ; Dinoprostone/biosynthesis/metabolism ; Humans ; Ischemia/drug therapy/metabolism ; Kidney/drug effects/*metabolism/physiology/physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; NAD/*biosynthesis ; Niacinamide/deficiency/pharmacology/therapeutic use ; Nicotinamide Phosphoribosyltransferase/metabolism ; Oxidation-Reduction ; Signal Transduction/drug effects ; Stress, Physiological ; Transcription Factors/deficiency/*metabolism
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  • 72
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    Nature Publishing Group (NPG)
    Publication Date: 2016-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urnov, Fyodor -- England -- Nature. 2016 Jan 28;529(7587):468-9. doi: 10.1038/529468a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sangamo BioSciences, Richmond, California 94804, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26819037" target="_blank"〉PubMed〈/a〉
    Keywords: CRISPR-Associated Proteins/*genetics/*metabolism ; CRISPR-Cas Systems/*physiology ; Clustered Regularly Interspaced Short Palindromic Repeats/*genetics ; Endonucleases/*metabolism ; *Genetic Engineering ; Genome, Human/*genetics ; Humans
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  • 73
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, Anthony -- England -- Nature. 2016 Mar 3;531(7592):S18-9. doi: 10.1038/531S18a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934522" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/metabolism ; Animals ; Brain/*physiology ; Bullying ; DNA Methylation ; Depression/complications/prevention & control/therapy ; Emotional Adjustment ; Epigenesis, Genetic/genetics ; Female ; Hippocampus/metabolism ; Humans ; Hydrocortisone/metabolism ; Maternal Behavior ; Memory/physiology ; Mice ; Models, Animal ; Oxytocin/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/genetics ; Psychological Trauma/complications/genetics/metabolism ; Rats ; *Resilience, Psychological ; Social Isolation/psychology ; Stress, Psychological/complications/genetics/metabolism/therapy
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  • 74
    Publication Date: 2016-03-05
    Description: HKU1 is a human betacoronavirus that causes mild yet prevalent respiratory disease, and is related to the zoonotic SARS and MERS betacoronaviruses, which have high fatality rates and pandemic potential. Cell tropism and host range is determined in part by the coronavirus spike (S) protein, which binds cellular receptors and mediates membrane fusion. As the largest known class I fusion protein, its size and extensive glycosylation have hindered structural studies of the full ectodomain, thus preventing a molecular understanding of its function and limiting development of effective interventions. Here we present the 4.0 A resolution structure of the trimeric HKU1 S protein determined using single-particle cryo-electron microscopy. In the pre-fusion conformation, the receptor-binding subunits, S1, rest above the fusion-mediating subunits, S2, preventing their conformational rearrangement. Surprisingly, the S1 C-terminal domains are interdigitated and form extensive quaternary interactions that occlude surfaces known in other coronaviruses to bind protein receptors. These features, along with the location of the two protease sites known to be important for coronavirus entry, provide a structural basis to support a model of membrane fusion mediated by progressive S protein destabilization through receptor binding and proteolytic cleavage. These studies should also serve as a foundation for the structure-based design of betacoronavirus vaccine immunogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860016/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860016/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirchdoerfer, Robert N -- Cottrell, Christopher A -- Wang, Nianshuang -- Pallesen, Jesper -- Yassine, Hadi M -- Turner, Hannah L -- Corbett, Kizzmekia S -- Graham, Barney S -- McLellan, Jason S -- Ward, Andrew B -- R56 AI118016/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2016 Mar 3;531(7592):118-21. doi: 10.1038/nature17200.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. ; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA. ; Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases, Building 40, Room 2502, 40 Convent Drive, Bethesda, Maryland 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26935699" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Coronavirus/*chemistry/*ultrastructure ; Cryoelectron Microscopy ; Humans ; Membrane Fusion ; Models, Molecular ; Protein Binding ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Proteolysis ; Receptors, Virus/metabolism ; Spike Glycoprotein, Coronavirus/*chemistry/metabolism/*ultrastructure ; Viral Vaccines/chemistry/immunology ; Virus Internalization
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  • 75
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, Sujata -- England -- Nature. 2016 Mar 3;531(7592):S12-3. doi: 10.1038/531S12a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934519" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Biological Availability ; Brain/*physiology ; Child ; Cognition/*physiology ; Dendrites/physiology ; Dietary Proteins ; Docosahexaenoic Acids/metabolism ; Eicosapentaenoic Acid/metabolism ; Female ; Humans ; Iron/administration & dosage/pharmacology ; *Meat ; Pregnancy ; Primates/physiology ; Vitamin B Complex ; Zinc
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  • 76
    Publication Date: 2016-01-15
    Description: Sulawesi is the largest and oldest island within Wallacea, a vast zone of oceanic islands separating continental Asia from the Pleistocene landmass of Australia and Papua (Sahul). By one million years ago an unknown hominin lineage had colonized Flores immediately to the south, and by about 50 thousand years ago, modern humans (Homo sapiens) had crossed to Sahul. On the basis of position, oceanic currents and biogeographical context, Sulawesi probably played a pivotal part in these dispersals. Uranium-series dating of speleothem deposits associated with rock art in the limestone karst region of Maros in southwest Sulawesi has revealed that humans were living on the island at least 40 thousand years ago (ref. 5). Here we report new excavations at Talepu in the Walanae Basin northeast of Maros, where in situ stone artefacts associated with fossil remains of megafauna (Bubalus sp., Stegodon and Celebochoerus) have been recovered from stratified deposits that accumulated from before 200 thousand years ago until about 100 thousand years ago. Our findings suggest that Sulawesi, like Flores, was host to a long-established population of archaic hominins, the ancestral origins and taxonomic status of which remain elusive.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Bergh, Gerrit D -- Li, Bo -- Brumm, Adam -- Grun, Rainer -- Yurnaldi, Dida -- Moore, Mark W -- Kurniawan, Iwan -- Setiawan, Ruly -- Aziz, Fachroel -- Roberts, Richard G -- Suyono -- Storey, Michael -- Setiabudi, Erick -- Morwood, Michael J -- England -- Nature. 2016 Jan 14;529(7585):208-11. doi: 10.1038/nature16448.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Archaeological Science, School of Earth &Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Naturalis Biodiversity Center, 2333 CR Leiden, The Netherlands. ; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia. ; School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Geology Museum Bandung, Geological Agency, Jalan Diponegoro 57, Bandung 40122, Indonesia. ; Archaeology, School of Humanities, University of New England, Armidale, New South Wales 2350, Australia. ; Quadlab, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 13 DK-1350 Copenhagen, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26762458" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Fossils ; History, Ancient ; *Hominidae ; Human Migration/history ; Humans ; Indonesia ; Tool Use Behavior
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  • 77
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Briggs, Adam -- England -- Nature. 2016 Mar 31;531(7596):551. doi: 10.1038/531551a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27029244" target="_blank"〉PubMed〈/a〉
    Keywords: Beverages/analysis/*economics ; Child ; Dietary Sucrose/*adverse effects ; Food Industry/*economics/*legislation & jurisprudence ; Great Britain ; *Health Policy ; Humans ; *Legislation, Food ; Obesity/epidemiology/prevention & control ; Pediatric Obesity/prevention & control ; Public Health/legislation & jurisprudence ; Taxes/*legislation & jurisprudence
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  • 78
    Publication Date: 2016-01-07
    Description: CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide off-target effects of the widely used Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing only partial or unproven efficacies and other limitations that constrain their use. Here we describe SpCas9-HF1, a high-fidelity variant harbouring alterations designed to reduce non-specific DNA contacts. SpCas9-HF1 retains on-target activities comparable to wild-type SpCas9 with 〉85% of single-guide RNAs (sgRNAs) tested in human cells. Notably, with sgRNAs targeted to standard non-repetitive sequences, SpCas9-HF1 rendered all or nearly all off-target events undetectable by genome-wide break capture and targeted sequencing methods. Even for atypical, repetitive target sites, the vast majority of off-target mutations induced by wild-type SpCas9 were not detected with SpCas9-HF1. With its exceptional precision, SpCas9-HF1 provides an alternative to wild-type SpCas9 for research and therapeutic applications. More broadly, our results suggest a general strategy for optimizing genome-wide specificities of other CRISPR-RNA-guided nucleases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleinstiver, Benjamin P -- Pattanayak, Vikram -- Prew, Michelle S -- Tsai, Shengdar Q -- Nguyen, Nhu T -- Zheng, Zongli -- Joung, J Keith -- DP1 GM105378/DP/NCCDPHP CDC HHS/ -- R01 GM088040/GM/NIGMS NIH HHS/ -- R01 GM107427/GM/NIGMS NIH HHS/ -- England -- Nature. 2016 Jan 28;529(7587):490-5. doi: 10.1038/nature16526. Epub 2016 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. ; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. ; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26735016" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; CRISPR-Associated Proteins/*genetics/*metabolism ; CRISPR-Cas Systems/*physiology ; Clustered Regularly Interspaced Short Palindromic Repeats/*genetics ; DNA/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Endonucleases/genetics/*metabolism ; *Genetic Engineering ; Genome, Human/*genetics ; Humans ; Mutation ; Protein Binding ; RNA/genetics ; Reproducibility of Results ; Sequence Analysis, DNA ; Streptococcus pyogenes/enzymology/genetics ; Substrate Specificity
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  • 79
    Publication Date: 2016-01-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Jan 28;529(7587):449. doi: 10.1038/529449a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26819024" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animals ; Animals, Laboratory ; Autistic Disorder/*genetics/physiopathology/psychology ; CRISPR-Cas Systems ; China ; DNA Copy Number Variations/genetics ; Deep Brain Stimulation ; *Disease Models, Animal ; Female ; *Genetic Engineering ; Humans ; Japan ; Macaca fascicularis/*genetics/psychology ; Male ; Methyl-CpG-Binding Protein 2/genetics ; Monkey Diseases/*genetics/physiopathology/psychology ; Neuroimaging
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  • 80
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 Feb 18;530(7590):253-4. doi: 10.1038/530253b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26887453" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/*trends ; Child ; *Federal Government ; *Goals ; Humans ; Immunotherapy ; Information Dissemination ; Neoplasms/*therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; United States
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  • 81
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reardon, Sara -- England -- Nature. 2016 Mar 10;531(7593):160-3. doi: 10.1038/531160a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26961640" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization/genetics/physiology ; African Swine Fever/immunology/virology ; Animal Culling/methods ; Animals ; Animals, Wild/genetics ; Bees/genetics/parasitology/physiology ; Breeding ; CRISPR-Cas Systems/*genetics ; Carps/anatomy & histology/genetics ; Cattle/genetics/immunology/physiology ; Chick Embryo/immunology ; Chickens/genetics ; Conservation of Natural Resources/methods ; Culicidae/genetics/parasitology ; Disease Models, Animal ; Disease Vectors ; Egg Hypersensitivity/prevention & control ; Elephants/genetics/physiology ; Extinction, Biological ; Female ; Food, Genetically Modified ; Genetic Engineering/*methods/trends ; Humans ; Infertility, Female/genetics ; Lyme Disease/prevention & control/transmission ; Macaca/genetics ; Malaria/prevention & control/transmission ; Mammoths/genetics/physiology ; Pets/anatomy & histology/genetics ; Rett Syndrome/genetics/physiopathology/psychology ; Salmon/genetics/growth & development ; Schistosomiasis/prevention & control/transmission ; Swine ; Swine, Miniature/anatomy & histology/genetics/immunology/virology
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  • 82
    Publication Date: 2016-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Jan 14;529(7585):136-7. doi: 10.1038/529136a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26762435" target="_blank"〉PubMed〈/a〉
    Keywords: Diffusion of Innovation ; *Federal Government ; History, 21st Century ; Humans ; Severe Acute Respiratory Syndrome/diagnosis/*epidemiology/prevention & control ; Taiwan/epidemiology
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  • 83
    Publication Date: 2016-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Jan 7;529(7584):9-10. doi: 10.1038/529009a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26738574" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *Federal Government ; Genome, Human/genetics ; Genomics/economics/manpower/trends ; Humans ; Physicians/supply & distribution ; Population Density ; Precision Medicine/economics/*trends ; Reproducibility of Results
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  • 84
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    Publication Date: 2016-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Apr 21;532(7599):300-2. doi: 10.1038/532300a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nature from Shanghai, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27111614" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry ; Animal Welfare/economics/legislation & jurisprudence/standards ; Animals ; *Animals, Laboratory/genetics ; Biological Evolution ; Biomedical Research/economics/legislation & jurisprudence/*methods/*trends ; CRISPR-Cas Systems/genetics ; Callithrix ; China ; Cooperative Behavior ; Disease Models, Animal ; Genetic Engineering ; *Haplorhini/genetics ; Humans ; International Cooperation ; Japan ; Neurosciences/methods/trends ; Research Personnel/organization & administration
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  • 85
    Publication Date: 2016-04-29
    Description: Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many life-saving regenerative therapies. However, despite their advantages for transplantation, their clinical use is restricted because HSCs in cord blood are found only in small numbers. Small molecules that enhance haematopoietic stem and progenitor cell (HSPC) expansion in culture have been identified, but in many cases their mechanisms of action or the nature of the pathways they impinge on are poorly understood. A greater understanding of the molecular circuitry that underpins the self-renewal of human HSCs will facilitate the development of targeted strategies that expand HSCs for regenerative therapies. Whereas transcription factor networks have been shown to influence the self-renewal and lineage decisions of human HSCs, the post-transcriptional mechanisms that guide HSC fate have not been closely investigated. Here we show that overexpression of the RNA-binding protein Musashi-2 (MSI2) induces multiple pro-self-renewal phenotypes, including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion of long-term repopulating HSCs. By performing a global analysis of MSI2-RNA interactions, we show that MSI2 directly attenuates aryl hydrocarbon receptor (AHR) signalling through post-transcriptional downregulation of canonical AHR pathway components in cord blood HSPCs. Our study gives mechanistic insight into RNA networks controlled by RNA-binding proteins that underlie self-renewal and provides evidence that manipulating such networks ex vivo can enhance the regenerative potential of human HSCs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880456/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880456/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentas, Stefan -- Holzapfel, Nicholas T -- Belew, Muluken S -- Pratt, Gabriel A -- Voisin, Veronique -- Wilhelm, Brian T -- Bader, Gary D -- Yeo, Gene W -- Hope, Kristin J -- HG004659/HG/NHGRI NIH HHS/ -- MOP-126030/Canadian Institutes of Health Research/Canada -- NS075449/NS/NINDS NIH HHS/ -- England -- Nature. 2016 Apr 28;532(7600):508-11. doi: 10.1038/nature17665.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8S 4K1, Canada. ; Department of Cellular and Molecular Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, California 92037, USA. ; Bioinformatics Graduate Program, University of California, San Diego, La Jolla, California 92037, USA. ; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. ; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec H3C 3J7, Canada. ; Department of Physiology, National University of Singapore and Molecular Engineering Laboratory, A*STAR, Singapore 138632, Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27121842" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/genetics/*metabolism ; Cell Count ; *Cell Self Renewal/genetics ; Down-Regulation/genetics ; Female ; Fetal Blood/cytology ; Gene Knockdown Techniques ; Hematopoietic Stem Cells/*cytology/*metabolism ; Humans ; Male ; Mice ; Protein Binding ; RNA, Messenger/genetics/metabolism ; RNA-Binding Proteins/genetics/*metabolism ; Receptors, Aryl Hydrocarbon/genetics/*metabolism ; *Signal Transduction/genetics
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  • 86
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 Feb 11;530(7589):129. doi: 10.1038/530129a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26863943" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil/epidemiology ; Databases, Factual/utilization ; Disease Outbreaks/statistics & numerical data ; Evidence-Based Medicine ; Humans ; *Information Dissemination ; Microcephaly/*epidemiology/etiology/virology ; *Open Access Publishing ; Sequence Analysis, DNA ; Time Factors ; World Health Organization ; *Zika Virus/genetics/pathogenicity ; Zika Virus Infection/*epidemiology/virology
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  • 87
    Publication Date: 2016-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cyranoski, David -- England -- Nature. 2016 Mar 24;531(7595):424-5. doi: 10.1038/nature.2016.19590.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27008970" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping/trends ; China ; Conservation of Natural Resources/trends ; Environmental Pollution/prevention & control ; Humans ; Neurosciences/trends ; Oceanography/trends ; Science/*trends ; Stem Cell Research
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  • 88
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wald, Chelsea -- England -- Nature. 2016 May 5;533(7601):S47. doi: 10.1038/533S47a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27144610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Austria ; Entrepreneurship/economics/organization & administration ; Humans ; Inventions/economics ; Inventors/economics/education/psychology ; Research/*economics/*organization & administration ; Research Personnel/economics/education/psychology ; *Technology Transfer ; Uncertainty
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  • 89
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 Feb 4;530(7588):5. doi: 10.1038/530005a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842018" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*virology ; Animals ; Brazil/epidemiology ; Female ; Humans ; Infectious Disease Transmission, Vertical/prevention & control/statistics & ; numerical data ; Microcephaly/epidemiology/etiology/virology ; Mosquito Control/*methods ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology/prevention & control/virology ; Rubella/epidemiology ; Tropical Climate ; Virology/*trends ; Zika Virus/isolation & purification/*pathogenicity ; Zika Virus Infection/*epidemiology/prevention & control/virology
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  • 90
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dance, Amber -- England -- Nature. 2016 Mar 3;531(7592):S2-3. doi: 10.1038/531S2a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26934523" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Amphetamines/adverse effects/pharmacology ; Animals ; Benzhydryl Compounds/pharmacology ; Biomedical Enhancement/ethics/*methods ; Caffeine/pharmacology ; Child ; Cognition/drug effects ; Dopamine/metabolism ; Healthy Volunteers ; Humans ; Intelligence/*drug effects ; Intelligence Tests ; Methylphenidate/adverse effects/pharmacology ; Neurotransmitter Agents/metabolism ; Nicotine/adverse effects/pharmacology ; Norepinephrine/metabolism ; Off-Label Use ; Performance-Enhancing Substances/adverse effects/*pharmacology ; Prefrontal Cortex/drug effects/physiology ; Rats ; Substance-Related Disorders/etiology ; Video Games/psychology
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  • 91
    Publication Date: 2016-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nardone, Roland M -- MacLeod, Roderick A F -- Capes-Davis, Amanda -- England -- Nature. 2016 Apr 21;532(7599):313.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27127813" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; DNA Contamination ; Databases, Factual ; *Disease Models, Animal ; Guidelines as Topic ; Heterografts/*standards ; Humans ; National Cancer Institute (U.S.) ; Neoplasms/*pathology ; Quality Control ; Reproducibility of Results ; United States ; Xenograft Model Antitumor Assays/*standards
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  • 92
    Publication Date: 2016-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2016 Feb 4;530(7588):13-4. doi: 10.1038/nature.2016.19259.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26842033" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil/epidemiology ; Diagnostic Errors/*statistics & numerical data ; Female ; Humans ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Microcephaly/*diagnosis/*epidemiology/etiology/virology ; Pregnancy ; *Uncertainty ; Zika Virus/isolation & purification/*pathogenicity ; Zika Virus Infection/*epidemiology/transmission/virology
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  • 93
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2016 Apr 14;532(7598):155-6. doi: 10.1038/532155a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075072" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/virology ; Angola/epidemiology ; Animals ; Asia/epidemiology ; Child ; Cities/epidemiology ; Disease Outbreaks/statistics & numerical data ; *Fear ; Haplorhini/virology ; Humans ; South America/epidemiology ; Strategic Stockpile/statistics & numerical data ; Vaccination/statistics & numerical data ; World Health Organization ; Yellow Fever/*epidemiology/*transmission/virology ; Yellow Fever Vaccine/administration & dosage/supply & distribution
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  • 94
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    Nature Publishing Group (NPG)
    Publication Date: 2016-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roy, Helen -- England -- Nature. 2016 Feb 18;530(7590):281. doi: 10.1038/530281d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NERC Centre for Ecology and Hydrology, Wallingford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26887485" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Diseases/epidemiology/*microbiology ; Animals ; Animals, Wild/*microbiology ; Biodiversity ; Biological Evolution ; Endangered Species/statistics & numerical data ; Host Specificity ; Humans ; Introduced Species/*statistics & numerical data
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  • 95
    Publication Date: 2016-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landry, Matt -- Gomes, Aldrin V -- England -- Nature. 2016 Jan 7;529(7584):25. doi: 10.1038/529025c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aviva Systems Biology, San Diego, California, USA. ; University of California, Davis, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26738583" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies/*immunology ; Biotechnology/*standards ; Blotting, Western/*methods/*standards ; Buffers ; Calibration ; Indicators and Reagents/standards ; Reproducibility of Results
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  • 96
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 May 11;533(7602):146. doi: 10.1038/533146a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27172009" target="_blank"〉PubMed〈/a〉
    Keywords: Device Approval/legislation & jurisprudence ; Drug Approval/legislation & jurisprudence ; Electronic Cigarettes/*adverse effects/utilization ; Humans ; Industry/legislation & jurisprudence ; Nicotine/administration & dosage/adverse effects/analysis ; Research Personnel ; Smoking/epidemiology/mortality/*prevention & control ; Tobacco Products/adverse effects/utilization ; United States ; United States Food and Drug Administration/*legislation & jurisprudence
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  • 97
    Publication Date: 2016-03-17
    Description: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory decline and subsequent loss of broader cognitive functions. Memory decline in the early stages of AD is mostly limited to episodic memory, for which the hippocampus has a crucial role. However, it has been uncertain whether the observed amnesia in the early stages of AD is due to disrupted encoding and consolidation of episodic information, or an impairment in the retrieval of stored memory information. Here we show that in transgenic mouse models of early AD, direct optogenetic activation of hippocampal memory engram cells results in memory retrieval despite the fact that these mice are amnesic in long-term memory tests when natural recall cues are used, revealing a retrieval, rather than a storage impairment. Before amyloid plaque deposition, the amnesia in these mice is age-dependent, which correlates with a progressive reduction in spine density of hippocampal dentate gyrus engram cells. We show that optogenetic induction of long-term potentiation at perforant path synapses of dentate gyrus engram cells restores both spine density and long-term memory. We also demonstrate that an ablation of dentate gyrus engram cells containing restored spine density prevents the rescue of long-term memory. Thus, selective rescue of spine density in engram cells may lead to an effective strategy for treating memory loss in the early stages of AD.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847731/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847731/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roy, Dheeraj S -- Arons, Autumn -- Mitchell, Teryn I -- Pignatelli, Michele -- Ryan, Tomas J -- Tonegawa, Susumu -- Howard Hughes Medical Institute/ -- England -- Nature. 2016 Mar 24;531(7595):508-12. doi: 10.1038/nature17172. Epub 2016 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. ; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26982728" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Alzheimer Disease/*pathology/*physiopathology ; Amnesia/pathology/physiopathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Dendritic Spines/pathology/physiology ; Dentate Gyrus/*cytology/pathology/*physiology/physiopathology ; *Disease Models, Animal ; Early Medical Intervention ; Humans ; Long-Term Potentiation ; Male ; Memory, Episodic ; Memory, Long-Term/*physiology ; Mice ; Mice, Transgenic ; Optogenetics ; Plaque, Amyloid ; Presenilin-1/genetics ; Synapses/metabolism ; Transgenes/genetics ; tau Proteins/genetics
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  • 98
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, Alvin E -- England -- Nature. 2016 Apr 14;532(7598):178. doi: 10.1038/532178a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University, California, USA. He shared the 2012 Nobel Memorial Prize in Economic Sciences with Lloyd Shapley.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075091" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Economics/*history ; Female ; *Game Theory ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Marketing/history ; Marriage/psychology ; Mathematics/*history ; Nobel Prize ; United States
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  • 99
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    Nature Publishing Group (NPG)
    Publication Date: 2016-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2016 May 11;533(7602):145. doi: 10.1038/533145a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27172008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety ; Biomedical Research/*trends ; Breast Feeding/*adverse effects ; Clinical Trials as Topic/ethics/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Milk, Human/*chemistry/*metabolism ; Mothers/psychology ; Pharmaceutical Preparations/*administration & dosage/*metabolism ; Risk Assessment ; Safety ; *Uncertainty ; United States ; United States Food and Drug Administration
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  • 100
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    Nature Publishing Group (NPG)
    Publication Date: 2016-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeClerck, Fabrice -- England -- Nature. 2016 Mar 17;531(7594):305. doi: 10.1038/531305e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bioversity International - CGIAR, Montpellier, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26983528" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*trends ; *Biodiversity ; Conservation of Natural Resources ; *Food Supply ; Goals ; Humans ; United Nations
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