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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grun, R -- Thorne, A -- New York, N.Y. -- Science. 1997 Jun 6;276(5318):1575-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research School of Pacific and Asian Studies, Australian National University, Canberra, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190691" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Electron Spin Resonance Spectroscopy ; *Fossils ; *Hominidae/anatomy & histology/classification ; Humans ; Indonesia ; Phylogeny ; Time ; Uranium/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-02-28
    Description: B lymphocytes have critical roles as positive and negative regulators of immunity. Their inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell-derived IL-10 can protect against autoimmune disease and increase susceptibility to pathogens. Here we identify IL-35-producing B cells as key players in the negative regulation of immunity. Mice in which only B cells did not express IL-35 lost their ability to recover from the T-cell-mediated demyelinating autoimmune disease experimental autoimmune encephalomyelitis (EAE). In contrast, these mice displayed a markedly improved resistance to infection with the intracellular bacterial pathogen Salmonella enterica serovar Typhimurium as shown by their superior containment of the bacterial growth and their prolonged survival after primary infection, and upon secondary challenge, compared to control mice. The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs). During Salmonella infection, IL-35- and IL-10-producing B cells corresponded to two largely distinct sets of surface-IgM(+)CD138(hi)TACI(+)CXCR4(+)CD1d(int)Tim1(int) plasma cells expressing the transcription factor Blimp1 (also known as Prdm1). During EAE, CD138(+) plasma cells were also the main source of B-cell-derived IL-35 and IL-10. Collectively, our data show the importance of IL-35-producing B cells in regulation of immunity and highlight IL-35 production by B cells as a potential therapeutic target for autoimmune and infectious diseases. This study reveals the central role of activated B cells, particularly plasma cells, and their production of cytokines in the regulation of immune responses in health and disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260166/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260166/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Ping -- Roch, Toralf -- Lampropoulou, Vicky -- O'Connor, Richard A -- Stervbo, Ulrik -- Hilgenberg, Ellen -- Ries, Stefanie -- Dang, Van Duc -- Jaimes, Yarua -- Daridon, Capucine -- Li, Rui -- Jouneau, Luc -- Boudinot, Pierre -- Wilantri, Siska -- Sakwa, Imme -- Miyazaki, Yusei -- Leech, Melanie D -- McPherson, Rhoanne C -- Wirtz, Stefan -- Neurath, Markus -- Hoehlig, Kai -- Meinl, Edgar -- Grutzkau, Andreas -- Grun, Joachim R -- Horn, Katharina -- Kuhl, Anja A -- Dorner, Thomas -- Bar-Or, Amit -- Kaufmann, Stefan H E -- Anderton, Stephen M -- Fillatreau, Simon -- 087833/Wellcome Trust/United Kingdom -- 095831/Wellcome Trust/United Kingdom -- G0801924/Medical Research Council/United Kingdom -- G0901697/Medical Research Council/United Kingdom -- G1100084/Medical Research Council/United Kingdom -- Canadian Institutes of Health Research/Canada -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2014 Mar 20;507(7492):366-70. doi: 10.1038/nature12979. Epub 2014 Feb 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Chariteplatz 1, 10117 Berlin, Germany [2]. ; 1] Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Chariteplatz 1, 10117 Berlin, Germany [2] Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, Kantstrasse 55, 14513 Teltow, Germany. [3]. ; Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Chariteplatz 1, 10117 Berlin, Germany. ; University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK. ; 1] Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Chariteplatz 1, 10117 Berlin, Germany [2] Charite Universitatsmedizin Berlin, CC12, Department of Medicine/Rheumatology and Clinical Immunology, 10117 Berlin, Germany. ; Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada. ; Virologie et Immunologie Moleculaires, INRA, 78352 Jouy-en-Josas, France. ; Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nurnberg, 91054 Erlangen, Germany. ; Institut fur Klinische Neuroimmunologie Klinikum der Ludwig-Maximilians-Universitat Munchen, 81377 Munchen, Germany. ; Immunpathologie, Research Center ImmunoSciences, 12203 Berlin, Germany. ; Max Planck Institute of Infection Biology, Department of Immunology, Chariteplatz 1, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24572363" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Presenting Cells/immunology/metabolism ; Antigens, CD40/immunology ; B-Lymphocytes/*immunology/*metabolism/secretion ; Encephalomyelitis, Autoimmune, Experimental/*immunology ; Female ; Humans ; Immunity/*immunology ; Interleukin-10/metabolism ; Interleukins/immunology/*metabolism/secretion ; Lymphocyte Activation ; Macrophages/cytology/immunology ; Male ; Mice ; Plasma Cells/immunology/metabolism ; Salmonella Infections/*immunology/microbiology ; T-Lymphocytes/immunology ; Toll-Like Receptor 4/immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2010-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Andrew P -- Grun, Rainer -- England -- Nature. 2010 Jul 8;466(7303):189-90. doi: 10.1038/466189a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20613827" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Archaeology ; *Climate ; Emigration and Immigration/*history ; Fossils ; Geologic Sediments/chemistry ; Great Britain ; History, Ancient ; *Hominidae ; Humans ; Magnetics ; Paleontology ; Seasons ; Technology/history/instrumentation ; Temperature
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2008-11-01
    Description: The expansion of modern human populations in Africa 80,000 to 60,000 years ago and their initial exodus out of Africa have been tentatively linked to two phases of technological and behavioral innovation within the Middle Stone Age of southern Africa-the Still Bay and Howieson's Poort industries-that are associated with early evidence for symbols and personal ornaments. Establishing the correct sequence of events, however, has been hampered by inadequate chronologies. We report ages for nine sites from varied climatic and ecological zones across southern Africa that show that both industries were short-lived (5000 years or less), separated by about 7000 years, and coeval with genetic estimates of population expansion and exit times. Comparison with climatic records shows that these bursts of innovative behavior cannot be explained by environmental factors alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, Zenobia -- Roberts, Richard G -- Galbraith, Rex F -- Deacon, Hilary J -- Grun, Rainer -- Mackay, Alex -- Mitchell, Peter -- Vogelsang, Ralf -- Wadley, Lyn -- New York, N.Y. -- Science. 2008 Oct 31;322(5902):733-5. doi: 10.1126/science.1162219.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉GeoQuEST Research Centre, School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. zenobia@uow.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18974351" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Southern ; *Anthropology, Physical ; *Archaeology ; Behavior ; Climate ; Culture ; Emigration and Immigration/history ; Geologic Sediments ; History, Ancient ; Humans ; Population Dynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2016-01-23
    Description: The nature of inter-group relations among prehistoric hunter-gatherers remains disputed, with arguments in favour and against the existence of warfare before the development of sedentary societies. Here we report on a case of inter-group violence towards a group of hunter-gatherers from Nataruk, west of Lake Turkana, which during the late Pleistocene/early Holocene period extended about 30 km beyond its present-day shore. Ten of the twelve articulated skeletons found at Nataruk show evidence of having died violently at the edge of a lagoon, into which some of the bodies fell. The remains from Nataruk are unique, preserved by the particular conditions of the lagoon with no evidence of deliberate burial. They offer a rare glimpse into the life and death of past foraging people, and evidence that warfare was part of the repertoire of inter-group relations among prehistoric hunter-gatherers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mirazon Lahr, M -- Rivera, F -- Power, R K -- Mounier, A -- Copsey, B -- Crivellaro, F -- Edung, J E -- Maillo Fernandez, J M -- Kiarie, C -- Lawrence, J -- Leakey, A -- Mbua, E -- Miller, H -- Muigai, A -- Mukhongo, D M -- Van Baelen, A -- Wood, R -- Schwenninger, J-L -- Grun, R -- Achyuthan, H -- Wilshaw, A -- Foley, R A -- England -- Nature. 2016 Jan 21;529(7586):394-8. doi: 10.1038/nature16477.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Leverhulme Centre for Human Evolutionary Studies, Department of Archaeology and Anthropology, University of Cambridge, Fitzwilliam Street, Cambridge CB2 1QH, UK. ; Turkana Basin Institute, Nairobi, Kenya. ; National Museums of Kenya, Jomo Kenyatta House, PO Box 152-30500, Lodwar, Kenya. ; Departamento de Prehistoria y Arqueologia, UNED, c/ Paseo Senda del Rey, 7, 28040 Madrid, Spain. ; National Museums of Kenya, PO Box 40658-00100, Nairobi, Kenya. ; Jomo Kenyatta University of Agriculture and Technology, PO Box 62000-00200, Nairobi, Kenya. ; Research School of Earth Sciences, The Australian National University, Building 142, Mills Road, Acton, Australian Capital Territory 2601, Australia. ; Research Laboratory for Archaeology and the History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK. ; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, 170 Kessels Road, Nathan, Queensland 4111, Australia. ; Department of Geology, Anna University, Chennai, Tamil Nadu 600025, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26791728" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2016-01-15
    Description: Sulawesi is the largest and oldest island within Wallacea, a vast zone of oceanic islands separating continental Asia from the Pleistocene landmass of Australia and Papua (Sahul). By one million years ago an unknown hominin lineage had colonized Flores immediately to the south, and by about 50 thousand years ago, modern humans (Homo sapiens) had crossed to Sahul. On the basis of position, oceanic currents and biogeographical context, Sulawesi probably played a pivotal part in these dispersals. Uranium-series dating of speleothem deposits associated with rock art in the limestone karst region of Maros in southwest Sulawesi has revealed that humans were living on the island at least 40 thousand years ago (ref. 5). Here we report new excavations at Talepu in the Walanae Basin northeast of Maros, where in situ stone artefacts associated with fossil remains of megafauna (Bubalus sp., Stegodon and Celebochoerus) have been recovered from stratified deposits that accumulated from before 200 thousand years ago until about 100 thousand years ago. Our findings suggest that Sulawesi, like Flores, was host to a long-established population of archaic hominins, the ancestral origins and taxonomic status of which remain elusive.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Bergh, Gerrit D -- Li, Bo -- Brumm, Adam -- Grun, Rainer -- Yurnaldi, Dida -- Moore, Mark W -- Kurniawan, Iwan -- Setiawan, Ruly -- Aziz, Fachroel -- Roberts, Richard G -- Suyono -- Storey, Michael -- Setiabudi, Erick -- Morwood, Michael J -- England -- Nature. 2016 Jan 14;529(7585):208-11. doi: 10.1038/nature16448.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Archaeological Science, School of Earth &Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Naturalis Biodiversity Center, 2333 CR Leiden, The Netherlands. ; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia. ; School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Geology Museum Bandung, Geological Agency, Jalan Diponegoro 57, Bandung 40122, Indonesia. ; Archaeology, School of Humanities, University of New England, Armidale, New South Wales 2350, Australia. ; Quadlab, Natural History Museum of Denmark, University of Copenhagen, Oster Voldgade 5-7, 13 DK-1350 Copenhagen, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26762458" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Fossils ; History, Ancient ; *Hominidae ; Human Migration/history ; Humans ; Indonesia ; Tool Use Behavior
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-03-31
    Description: Homo floresiensis, a primitive hominin species discovered in Late Pleistocene sediments at Liang Bua (Flores, Indonesia), has generated wide interest and scientific debate. A major reason this taxon is controversial is because the H. floresiensis-bearing deposits, which include associated stone artefacts and remains of other extinct endemic fauna, were dated to between about 95 and 12 thousand calendar years (kyr) ago. These ages suggested that H. floresiensis survived until long after modern humans reached Australia by ~50 kyr ago. Here we report new stratigraphic and chronological evidence from Liang Bua that does not support the ages inferred previously for the H. floresiensis holotype (LB1), ~18 thousand calibrated radiocarbon years before present (kyr cal. BP), or the time of last appearance of this species (about 17 or 13-11 kyr cal. BP). Instead, the skeletal remains of H. floresiensis and the deposits containing them are dated to between about 100 and 60 kyr ago, whereas stone artefacts attributable to this species range from about 190 to 50 kyr in age. Whether H. floresiensis survived after 50 kyr ago--potentially encountering modern humans on Flores or other hominins dispersing through southeast Asia, such as Denisovans--is an open question.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sutikna, Thomas -- Tocheri, Matthew W -- Morwood, Michael J -- Saptomo, E Wahyu -- Jatmiko -- Awe, Rokus Due -- Wasisto, Sri -- Westaway, Kira E -- Aubert, Maxime -- Li, Bo -- Zhao, Jian-xin -- Storey, Michael -- Alloway, Brent V -- Morley, Mike W -- Meijer, Hanneke J M -- van den Bergh, Gerrit D -- Grun, Rainer -- Dosseto, Anthony -- Brumm, Adam -- Jungers, William L -- Roberts, Richard G -- England -- Nature. 2016 Apr 21;532(7599):366-9. doi: 10.1038/nature17179. Epub 2016 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Archaeological Science, School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Pusat Penelitian Arkeologi Nasional, Jakarta 12510, Indonesia. ; Department of Anthropology, Lakehead University, Thunder Bay, Ontario P7B 5E1, Canada. ; Human Origins Program, Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC 20013, USA. ; Traps MQ Luminescence Dating Facility, Department of Environmental Sciences, Macquarie University, Sydney, New South Wales 2109, Australia. ; Research Centre for Human Evolution, Place, Evolution and Rock Art Heritage Unit, Griffith University, Gold Coast, Queensland 4222, Australia. ; School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; School of Earth Sciences, University of Queensland, Brisbane, Queensland 4072, Australia. ; QUADLAB, Section of Earth and Planetary System Science, Natural History Museum of Denmark, 1350 Copenhagen, Denmark. ; School of Geography, Environment and Earth Sciences, Victoria University of Wellington, Wellington 6012, New Zealand. ; Department of Natural History, University Museum of Bergen, University of Bergen, 5007 Bergen, Norway. ; Research Centre for Human Evolution, Environmental Futures Research Institute, Griffith University, Brisbane, Queensland 4111, Australia. ; Research School of Earth Sciences, Australian National University, Canberra, Australian Capital Territory 0200, Australia. ; GeoQuEST Research Centre, School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. ; Department of Anatomical Sciences, Stony Brook University Medical Center, Stony Brook, New York 11794, USA. ; Association Vahatra, BP 3972, Antananarivo 101, Madagascar.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27027286" target="_blank"〉PubMed〈/a〉
    Keywords: Aluminum Silicates ; Animals ; *Archaeology ; Australia ; Calibration ; Caves ; *Fossils ; Geologic Sediments/analysis ; Glass ; *Hominidae ; Humans ; Indonesia ; Potassium Compounds ; Quartz ; *Radiometric Dating ; Time Factors ; Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1996-04-02
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2018
    Description: 〈p〉Scholars endeavor to understand the relationship between human evolution and climate change. This is particularly germane for Neanderthals, who survived extreme Eurasian environmental variation and glaciations, mysteriously going extinct during a cool interglacial stage. Here, we integrate weekly records of climate, tooth growth, and metal exposure in two Neanderthals and one modern human from southeastern France. The Neanderthals inhabited cooler and more seasonal periods than the modern human, evincing childhood developmental stress during wintertime. In one instance, this stress may have included skeletal mobilization of elemental stores and weight loss; this individual was born in the spring and appears to have weaned 2.5 years later. Both Neanderthals were exposed to lead at least twice during the deep winter and/or early spring. This multidisciplinary approach elucidates direct relationships between ancient environments and hominin paleobiology.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 10
    Publication Date: 2018
    Description: 〈p〉Our original claim, based on three independent numerical dating methods, of an age of ~185,000 years for the Misliya-1 modern human hemi-maxilla from Mount Carmel, Israel, is little affected by discounting uranium-series dating of adhering crusts. It confirms a much earlier out-of-Africa 〈i〉Homo sapiens〈/i〉 expansion than previously suggested by the considerably younger (90,000 to 120,000 years) Skhul/Qafzeh hominins.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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