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  • Humans  (679)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: Converging legal and scientific forces are pushing the traditional forensic identification sciences toward fundamental change. The assumption of discernible uniqueness that resides at the core of these fields is weakened by evidence of errors in proficiency testing and in actual cases. Changes in the law pertaining to the admissibility of expert evidence in court, together with the emergence of DNA typing as a model for a scientifically defensible approach to questions of shared identity, are driving the older forensic sciences toward a new scientific paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saks, Michael J -- Koehler, Jonathan J -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):892-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Law, Arizona State University, Tempe, AZ 85287, USA. saks@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081727" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/classification ; Expert Testimony ; Forecasting ; Forensic Sciences/legislation & jurisprudence/*trends ; Humans ; Models, Theoretical ; Reproducibility of Results
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2005-11-29
    Description: The estimation of the reward an action will yield is critical in decision-making. To elucidate the role of the basal ganglia in this process, we recorded striatal neurons of monkeys who chose between left and right handle turns, based on the estimated reward probabilities of the actions. During a delay period before the choices, the activity of more than one-third of striatal projection neurons was selective to the values of one of the two actions. Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samejima, Kazuyuki -- Ueda, Yasumasa -- Doya, Kenji -- Kimura, Minoru -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1337-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619-0288 Kyoto, Japan. samejima@lab.tamagawa.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311337" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Caudate Nucleus/*physiology ; *Choice Behavior ; Corpus Striatum/*physiology ; Female ; Macaca ; Male ; Neurons/*physiology ; Probability ; Putamen/*physiology ; Regression Analysis ; Reinforcement (Psychology) ; *Reward
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohman, James C -- Lovejoy, C Owen -- White, Tim D -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):845; author reply 845.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15709231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Femoral Neck Fractures/pathology ; Femur/*anatomy & histology/radiography ; Femur Neck/anatomy & histology/radiography ; *Fossils ; Hominidae/*anatomy & histology/physiology ; Humans ; Locomotion ; Tomography, X-Ray Computed
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1550.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761133" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/anatomy & histology/*pathology ; Brain Diseases/*diagnosis ; *Diagnostic Imaging ; Humans ; *Incidental Findings ; *Research Subjects
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: It is important for animals to estimate the value of rewards as accurately as possible. Because the number of potential reward values is very large, it is necessary that the brain's limited resources be allocated so as to discriminate better among more likely reward outcomes at the expense of less likely outcomes. We found that midbrain dopamine neurons rapidly adapted to the information provided by reward-predicting stimuli. Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tobler, Philippe N -- Fiorillo, Christopher D -- Schultz, Wolfram -- 095495/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1642-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK, and Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761155" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Animals ; Discrimination (Psychology) ; Dopamine/*physiology ; Electrophysiology ; Female ; Learning ; Macaca fascicularis ; Mesencephalon/cytology/*physiology ; Neurons/*physiology ; Photic Stimulation ; Probability ; *Reward
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  • 6
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1857.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790821" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Cell Line ; Cloning, Organism ; *Embryo Research/economics/legislation & jurisprudence ; Embryo, Mammalian/*cytology ; Humans ; *Research Support as Topic/legislation & jurisprudence ; *Stem Cells ; Tissue Donors/legislation & jurisprudence
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1548-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761132" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/*anatomy & histology/*physiology ; Confidentiality ; Deception ; *Diagnostic Imaging ; Humans ; *Mental Processes ; *Personality ; *Privacy
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: Dominance hierarchies occur in numerous social species, and rank within them can greatly influence the quality of life of an animal. In this review, I consider how rank can also influence physiology and health. I first consider whether it is high- or low-ranking animals that are most stressed in a dominance hierarchy; this turns out to vary as a function of the social organization in different species and populations. I then review how the stressful characteristics of social rank have adverse adrenocortical, cardiovascular, reproductive, immunological, and neurobiological consequences. Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sapolsky, Robert M -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):648-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305-5020, USA. sapolsky@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety ; Behavior, Animal ; Cardiovascular Physiological Phenomena ; Catecholamines/metabolism ; Dominance-Subordination ; *Health Status ; Humans ; Hydrocortisone/metabolism ; Immune System/physiology ; Nervous System Physiological Phenomena ; *Primates/physiology/psychology ; Reproduction ; *Social Behavior ; Social Class ; *Social Dominance ; *Stress, Physiological/physiopathology
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  • 9
    Publication Date: 2005-06-11
    Description: We show that inferences of competence based solely on facial appearance predicted the outcomes of U.S. congressional elections better than chance (e.g., 68.8% of the Senate races in 2004) and also were linearly related to the margin of victory. These inferences were specific to competence and occurred within a 1-second exposure to the faces of the candidates. The findings suggest that rapid, unreflective trait inferences can contribute to voting choices, which are widely assumed to be based primarily on rational and deliberative considerations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todorov, Alexander -- Mandisodza, Anesu N -- Goren, Amir -- Hall, Crystal C -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Princeton University, Princeton, NJ 08544, USA. atodorov@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947187" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Character ; Decision Making ; *Face/anatomy & histology ; Federal Government ; Female ; Forecasting ; Humans ; Intelligence ; Judgment ; Leadership ; Male ; *Mental Competency ; *Politics ; *Social Perception ; Stereotyping ; Trust ; United States
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):43-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210515" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autophagy ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Clinical Trials as Topic ; Corpus Striatum/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Huntington Disease/*drug therapy/genetics/pathology/*physiopathology ; Mice ; Mitochondria/metabolism ; Mutation ; Nerve Tissue Proteins/chemistry/*genetics/metabolism/*physiology ; Neurons/*physiology ; Nuclear Proteins/chemistry/*genetics/metabolism/*physiology ; Peptides ; Transcription Factors/metabolism ; Trinucleotide Repeat Expansion
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  • 11
    Publication Date: 2005-02-19
    Description: Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector. The rictor-mTOR complex directly phosphorylated Akt/PKB on Ser473 in vitro and facilitated Thr308 phosphorylation by PDK1. Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sarbassov, D D -- Guertin, David A -- Ali, Siraj M -- Sabatini, David M -- R01 AI47389/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1098-101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718470" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Phosphoinositide-Dependent Protein Kinases ; Adaptor Proteins, Signal Transducing ; Animals ; Carrier Proteins/*metabolism ; Cell Line ; Cell Line, Tumor ; Drosophila Proteins/*metabolism ; Drosophila melanogaster ; Enzyme Activation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Immunoprecipitation ; Phosphatidylinositol 3-Kinases/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Protein-Serine-Threonine Kinases/*metabolism ; Proteins/metabolism ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-akt ; RNA Interference ; Serine/metabolism ; TOR Serine-Threonine Kinases
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1395.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bioterrorism/prevention & control ; Botulinum Toxins ; Food Supply ; Humans ; Milk ; *Periodicals as Topic ; Publishing ; *Retraction of Publication as Topic ; United States ; *United States Dept. of Health and Human Services
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1026.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718436" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Bias (Epidemiology) ; Cohort Studies ; Confounding Factors (Epidemiology) ; Epidemiologic Methods ; Humans ; *Immunization Programs ; *Influenza Vaccines ; Influenza, Human/*mortality/*prevention & control ; United States/epidemiology
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  • 14
    Publication Date: 2005-02-01
    Description: Pollen tube guidance precedes the double fertilization of flowering plants. Here, we report the identification of a small maize protein of 94 amino acids involved in short-range signaling required for pollen tube attraction by the female gametophyte. ZmEA1 is exclusively expressed in the egg apparatus, consisting of the egg cell and two synergids. Chimeric ZmEA1 fused to green fluorescent protein (ZmEA1:GFP) was first visible within the filiform apparatus and later was localized to nucellar cell walls below the micropylar opening of the ovule. Transgenic down-regulation of the ZmEA1 gene led to ovule sterility caused by loss of close-range pollen tube guidance to the micropyle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marton, Mihaela L -- Cordts, Simone -- Broadhvest, Jean -- Dresselhaus, Thomas -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):573-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biocenter Klein Flottbek, Developmental Biology and Biotechnology, University of Hamburg, Ohnhorststrasse 18, D-22609 Hamburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681383" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antisense Elements (Genetics) ; Crosses, Genetic ; DNA, Complementary ; Flowers/growth & development/*physiology ; Genes, Plant ; Green Fluorescent Proteins/metabolism ; Molecular Sequence Data ; Plant Proteins/chemistry/*genetics/*physiology ; Plants, Genetically Modified ; Promoter Regions, Genetic ; Protein Structure, Tertiary ; RNA Interference ; Recombinant Fusion Proteins/metabolism ; Reproduction ; Seeds/physiology ; Sequence Homology, Nucleic Acid ; Signal Transduction ; Zea mays/*genetics/*physiology
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: Funding bodies are coming to the aid of young scientists with a variety of programs aimed at helping them become independent investigators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forde, Anne -- Pain, Elisabeth -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):427-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831761" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Mobility ; Education, Graduate ; *Faculty ; *Fellowships and Scholarships ; Great Britain ; Humans ; Ireland ; *Research Personnel ; *Research Support as Topic ; Universities
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Inman, Mason -- New York, N.Y. -- Science. 2005 May 13;308(5724):937.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890852" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; *Ecosystem ; Environment ; Fisheries ; *Fishes ; North Sea ; Population Dynamics ; *Seawater ; Temperature
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):864-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081709" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Alzheimer Disease/epidemiology/*prevention & control ; Animals ; Brain/physiology ; Education ; *Exercise ; Female ; Humans ; Life Style ; Male ; *Mental Processes
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  • 18
    Publication Date: 2005-04-16
    Description: An oviraptosaurian specimen (Dinosauria, Theropoda) from an Upper Cretaceous formation in China retains a pair of shelled eggs in the pelvis, providing direct evidence that oviraptorosaurian dinosaurs laid paired elongatoolithid eggs. The presence of the paired eggs suggests that theropod dinosaurs had two functional oviducts (like crocodiles) but that each oviduct produced only one egg at a time and that an entire egg clutch was laid through multiple ovipositions (like birds). The orientations of the eggs inside the skeleton and in clutches indicate that the mother came to the center of the nest to lay eggs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sato, Tamaki -- Cheng, Yen-nien -- Wu, Xiao-chun -- Zelenitsky, Darla K -- Hsiao, Yu-fu -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):375.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Canadian Museum of Nature (CMN), Post Office Box 3443, STN D, Ottawa, Ontario K1P 6P4, Canada. tsato@mus-nature.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dinosaurs/anatomy & histology/*physiology ; *Egg Shell ; Female ; *Fossils ; Oviducts/anatomy & histology/physiology ; *Oviposition ; *Ovum
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  • 19
    Publication Date: 2005-10-29
    Description: Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomlins, Scott A -- Rhodes, Daniel R -- Perner, Sven -- Dhanasekaran, Saravana M -- Mehra, Rohit -- Sun, Xiao-Wei -- Varambally, Sooryanarayana -- Cao, Xuhong -- Tchinda, Joelle -- Kuefer, Rainer -- Lee, Charles -- Montie, James E -- Shah, Rajal B -- Pienta, Kenneth J -- Rubin, Mark A -- Chinnaiyan, Arul M -- 5P30 CA46592/CA/NCI NIH HHS/ -- P50CA69568/CA/NCI NIH HHS/ -- R01 CA97063/CA/NCI NIH HHS/ -- R01AG21404/AG/NIA NIH HHS/ -- UO1 CA111275-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):644-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254181" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/*genetics ; Gene Expression Regulation, Neoplastic ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Neoplasm Proteins/*genetics ; Oncogene Proteins, Fusion/*genetics ; Polymerase Chain Reaction ; Prostatic Neoplasms/*genetics ; Serine Endopeptidases/*genetics ; Trans-Activators/*genetics ; Transcription Factors/*genetics ; Translocation, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1851.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790813" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Energy Metabolism ; Female ; Fraud ; History, 20th Century ; History, 21st Century ; Humans ; Menopause ; *National Institutes of Health (U.S.) ; *Publishing ; *Research Support as Topic ; Retraction of Publication as Topic ; *Scientific Misconduct ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawa, Akira -- Snyder, Solomon H -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1128-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. asawa1@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293746" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/physiology ; Affective Disorders, Psychotic/enzymology/*genetics ; Carrier Proteins/physiology ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Humans ; Mutation ; Nerve Tissue Proteins/*genetics/physiology ; Protein Binding ; Schizophrenia/*genetics ; Signal Transduction ; Translocation, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):23-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637239" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group/genetics ; Chemokines, CC/*genetics ; European Continental Ancestry Group/genetics ; *Gene Dosage ; Gene Duplication ; *Genetic Predisposition to Disease ; HIV Infections/*genetics ; Humans
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  • 23
    Publication Date: 2005-07-26
    Description: Land use has generally been considered a local environmental issue, but it is becoming a force of global importance. Worldwide changes to forests, farmlands, waterways, and air are being driven by the need to provide food, fiber, water, and shelter to more than six billion people. Global croplands, pastures, plantations, and urban areas have expanded in recent decades, accompanied by large increases in energy, water, and fertilizer consumption, along with considerable losses of biodiversity. Such changes in land use have enabled humans to appropriate an increasing share of the planet's resources, but they also potentially undermine the capacity of ecosystems to sustain food production, maintain freshwater and forest resources, regulate climate and air quality, and ameliorate infectious diseases. We face the challenge of managing trade-offs between immediate human needs and maintaining the capacity of the biosphere to provide goods and services in the long term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foley, Jonathan A -- Defries, Ruth -- Asner, Gregory P -- Barford, Carol -- Bonan, Gordon -- Carpenter, Stephen R -- Chapin, F Stuart -- Coe, Michael T -- Daily, Gretchen C -- Gibbs, Holly K -- Helkowski, Joseph H -- Holloway, Tracey -- Howard, Erica A -- Kucharik, Christopher J -- Monfreda, Chad -- Patz, Jonathan A -- Prentice, I Colin -- Ramankutty, Navin -- Snyder, Peter K -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):570-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Sustainability and the Global Environment (SAGE), University of Wisconsin, 1710 University Avenue, Madison, WI 53726, USA. jfoley@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040698" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Air Pollution ; Animals ; Animals, Wild ; Climate ; Communicable Diseases/epidemiology/transmission ; *Conservation of Natural Resources ; *Ecosystem ; *Environment ; Fresh Water ; Human Activities ; Humans ; Policy Making ; Trees
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):836-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705823" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Division ; Cell Nucleus/*metabolism ; Centromere/physiology ; Chromosome Segregation ; DNA Repair ; GTPase-Activating Proteins/metabolism ; Gene Expression Regulation ; Humans ; Molecular Chaperones ; Neurodegenerative Diseases/metabolism ; Nuclear Pore Complex Proteins/metabolism ; Proteins/*metabolism ; Small Ubiquitin-Related Modifier Proteins/chemistry/*physiology ; Spindle Apparatus/metabolism ; Transcription Factors/*metabolism ; Viral Proteins/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: Large numbers of noncoding RNA transcripts (ncRNAs) are being revealed by complementary DNA cloning and genome tiling array studies in animals. The big and as yet largely unanswered question is whether these transcripts are relevant. A paper by Willingham et al. shows the way forward by developing a strategy for large-scale functional screening of ncRNAs, involving small interfering RNA knockdowns in cell-based screens, which identified a previously unidentified ncRNA repressor of the transcription factor NFAT. It appears likely that ncRNAs constitute a critical hidden layer of gene regulation in complex organisms, the understanding of which requires new approaches in functional genomics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mattick, John S -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1527-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. j.mattick@imb.uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141063" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Conserved Sequence ; DNA-Binding Proteins/antagonists & inhibitors ; *Genomics ; Humans ; Mice ; NFATC Transcription Factors ; Nuclear Proteins/antagonists & inhibitors ; *RNA Interference ; RNA, Untranslated/antagonists & inhibitors/genetics/*physiology ; Transcription Factors/antagonists & inhibitors ; beta Karyopherins/metabolism
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  • 26
    Publication Date: 2005-01-22
    Description: Territorial behavior is expected to buffer populations against short-term environmental perturbations, but we have found that group living in African lions causes a complex response to long-term ecological change. Despite numerous gradual changes in prey availability and vegetative cover, regional populations of Serengeti lions remained stable for 10- to 20-year periods and only shifted to new equilibria in sudden leaps. Although gradually improving environmental conditions provided sufficient resources to permit the subdivision of preexisting territories, regional lion populations did not expand until short-term conditions supplied enough prey to generate large cohorts of surviving young. The results of a simulation model show that the observed pattern of "saltatory equilibria" results from the lions' grouping behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Packer, Craig -- Hilborn, Ray -- Mosser, Anna -- Kissui, Bernard -- Borner, Markus -- Hopcraft, Grant -- Wilmshurst, John -- Mduma, Simon -- Sinclair, Anthony R E -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):390-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution, and Behavior, University of Minnesota, 1987 Upper Buford Circle, Saint Paul, MN 55108, USA. packer@cbs.umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662005" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Antelopes ; *Behavior, Animal ; *Ecosystem ; Environment ; Female ; *Lions/physiology ; Male ; Models, Biological ; Plants ; Population Density ; Population Dynamics ; Predatory Behavior ; Reproduction ; Seasons ; Social Behavior ; Stochastic Processes ; Tanzania ; *Territoriality
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1890-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373546" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Aspirin/therapeutic use ; Celecoxib ; Confounding Factors (Epidemiology) ; Cyclooxygenase 1 ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Cyclooxygenase Inhibitors/adverse effects/*therapeutic use ; Drug Interactions ; Heart Diseases/*drug therapy ; Humans ; Ibuprofen/therapeutic use ; Membrane Proteins/antagonists & inhibitors ; Naproxen/therapeutic use ; Pyrazoles/adverse effects/*therapeutic use ; Randomized Controlled Trials as Topic/ethics/methods/standards ; *Research Design ; Sulfonamides/adverse effects/*therapeutic use
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  • 28
    Publication Date: 2005-06-11
    Description: In animal societies, chemical communication plays an important role in conflict and cooperation. For ants, cuticular hydrocarbon (CHC) blends produced by non-nestmates elicit overt aggression. We describe a sensory sensillum on the antennae of the carpenter ant Camponotus japonicus that functions in nestmate discrimination. This sensillum is multiporous and responds only to non-nestmate CHC blends. This suggests a role for a peripheral recognition mechanism in detecting colony-specific chemical signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ozaki, Mamiko -- Wada-Katsumata, Ayako -- Fujikawa, Kazuyo -- Iwasaki, Masayuki -- Yokohari, Fumio -- Satoji, Yuji -- Nisimura, Tomoyosi -- Yamaoka, Ryohei -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):311-4. Epub 2005 Jun 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. mamiko@kit.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947139" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Amino Acid Sequence ; Animals ; Ants/*physiology ; Base Sequence ; *Behavior, Animal ; Carrier Proteins/chemistry/isolation & purification/metabolism ; Chemoreceptor Cells/*physiology ; Cues ; Electrophysiology ; *Hydrocarbons ; Insect Proteins/chemistry/isolation & purification/metabolism ; Microscopy, Electron, Scanning ; Molecular Sequence Data ; Neurons, Afferent/*physiology ; Sense Organs/physiology ; Social Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254155" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; Genomics ; *Haplotypes ; Humans
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  • 30
    Publication Date: 2005-12-17
    Description: Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols). These domains are required for binding of poleta and poliota to ubiquitin, their accumulation in replication factories, and their interaction with monoubiquitinated PCNA. Moreover, the UBZ domain of poleta is essential to efficiently restore a normal response to ultraviolet irradiation in xeroderma pigmentosum variant (XP-V) fibroblasts. Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bienko, Marzena -- Green, Catherine M -- Crosetto, Nicola -- Rudolf, Fabian -- Zapart, Grzegorz -- Coull, Barry -- Kannouche, Patricia -- Wider, Gerhard -- Peter, Matthias -- Lehmann, Alan R -- Hofmann, Kay -- Dikic, Ivan -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Cell Line ; Computational Biology ; DNA/*biosynthesis ; *DNA Damage ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/*chemistry/genetics/*metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Point Mutation ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/metabolism ; Transfection ; Ubiquitin/*metabolism ; Xeroderma Pigmentosum/genetics ; Zinc Fingers
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1665.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16150988" target="_blank"〉PubMed〈/a〉
    Keywords: Breast/*anatomy & histology ; Breast Neoplasms/etiology ; Female ; Humans ; *Mammography ; Risk Factors ; *Software
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  • 32
    Publication Date: 2005-02-05
    Description: The gene encoding the Nod2 protein is frequently mutated in Crohn's disease (CD) patients, although the physiological function of Nod2 in the intestine remains elusive. Here we show that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod2-deficient mice. These animals are susceptible to bacterial infection via the oral route but not through intravenous or peritoneal delivery. Nod2 is required for the expression of a subgroup of intestinal anti-microbial peptides, known as cryptdins. The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kobayashi, Koichi S -- Chamaillard, Mathias -- Ogura, Yasunori -- Henegariu, Octavian -- Inohara, Naohiro -- Nunez, Gabriel -- Flavell, Richard A -- New York, N.Y. -- Science. 2005 Feb 4;307(5710):731-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15692051" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylmuramyl-Alanyl-Isoglutamine/*immunology ; Animals ; *Antibody Formation ; Female ; Gene Expression ; Gene Targeting ; Ileum/*immunology/microbiology ; *Immunity, Innate ; Immunity, Mucosal ; Immunoglobulins/biosynthesis ; Interleukins/biosynthesis ; Intestinal Diseases/immunology/microbiology ; Intestinal Mucosa/immunology/microbiology ; Intracellular Signaling Peptides and Proteins/*physiology ; Ligands ; Lipopolysaccharides/toxicity ; Listeria monocytogenes/growth & development/immunology/isolation & purification ; Listeriosis/*immunology/microbiology ; Liver/microbiology ; Macrophages/immunology ; Male ; Membrane Glycoproteins/physiology ; Mice ; Nod2 Signaling Adaptor Protein ; Oligonucleotide Array Sequence Analysis ; Protein Precursors/biosynthesis/genetics ; Receptors, Cell Surface/physiology ; Serum Albumin/immunology ; Signal Transduction ; Spleen/microbiology ; Toll-Like Receptors ; Tumor Necrosis Factor-alpha/biosynthesis ; alpha-Defensins/*biosynthesis/genetics
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  • 33
    Publication Date: 2005-06-11
    Description: Biological control of malaria mosquitoes in Africa has rarely been used in vector control programs. Recent developments in this field show that certain fungi are virulent to adult Anopheles mosquitoes. Practical delivery of an entomopathogenic fungus that infected and killed adult Anopheles gambiae, Africa's main malaria vector, was achieved in rural African village houses. An entomological inoculation rate model suggests that implementation of this vector control method, even at the observed moderate coverage during a field study in Tanzania, would significantly reduce malaria transmission intensity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scholte, Ernst-Jan -- Ng'habi, Kija -- Kihonda, Japheth -- Takken, Willem -- Paaijmans, Krijn -- Abdulla, Salim -- Killeen, Gerry F -- Knols, Bart G J -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1641-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Entomology, Wageningen University and Research Centre, Post Office Box 8031, 6700 EH Wageningen, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947190" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*microbiology/parasitology/physiology ; Culex/microbiology/physiology ; Female ; Housing ; *Hypocreales/pathogenicity/physiology ; Insect Vectors/*microbiology/parasitology/physiology ; Longevity ; Malaria/prevention & control/transmission ; Male ; *Mitosporic Fungi/pathogenicity/physiology ; Models, Biological ; *Pest Control, Biological ; Plasmodium ; Spores, Fungal ; Tanzania
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1310-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123271" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*genetics ; Animals ; Blood Glucose/analysis ; Female ; Glucuronidase ; Insulin/blood/metabolism ; Insulin Resistance ; Insulin-Like Growth Factor I/metabolism ; Longevity/*genetics ; Male ; Membrane Proteins/blood/*genetics/*physiology ; Mice ; Mutation ; Signal Transduction
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):684-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051760" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Blood Specimen Collection ; *Dna ; *Databases, Genetic ; Genetic Privacy ; Humans ; *Medical Records Systems, Computerized ; New York ; United States ; *United States Department of Veterans Affairs ; *Universities ; *Veterans
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):83.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994529" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Caloric Restriction ; Forecasting ; Humans ; Insulin-Like Growth Factor I/metabolism ; *Life Expectancy/trends ; *Longevity ; Oxidative Stress
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kone-Cni, Vladimir J -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793900" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; *Prisoners ; *Psychology, Social ; *Torture ; United States ; Warfare
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):728.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticholesteremic Agents/therapeutic use ; *Biomedical Research/economics ; *Chemistry, Pharmaceutical/economics ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry/economics ; Humans ; *Research Personnel/economics ; *Technology, Pharmaceutical/economics
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  • 39
    Publication Date: 2005-10-29
    Description: Global change will alter the supply of ecosystem services that are vital for human well-being. To investigate ecosystem service supply during the 21st century, we used a range of ecosystem models and scenarios of climate and land-use change to conduct a Europe-wide assessment. Large changes in climate and land use typically resulted in large changes in ecosystem service supply. Some of these trends may be positive (for example, increases in forest area and productivity) or offer opportunities (for example, "surplus land" for agricultural extensification and bioenergy production). However, many changes increase vulnerability as a result of a decreasing supply of ecosystem services (for example, declining soil fertility, declining water availability, increasing risk of forest fires), especially in the Mediterranean and mountain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schroter, Dagmar -- Cramer, Wolfgang -- Leemans, Rik -- Prentice, I Colin -- Araujo, Miguel B -- Arnell, Nigel W -- Bondeau, Alberte -- Bugmann, Harald -- Carter, Timothy R -- Gracia, Carlos A -- de la Vega-Leinert, Anne C -- Erhard, Markus -- Ewert, Frank -- Glendining, Margaret -- House, Joanna I -- Kankaanpaa, Susanna -- Klein, Richard J T -- Lavorel, Sandra -- Lindner, Marcus -- Metzger, Marc J -- Meyer, Jeannette -- Mitchell, Timothy D -- Reginster, Isabelle -- Rounsevell, Mark -- Sabate, Santi -- Sitch, Stephen -- Smith, Ben -- Smith, Jo -- Smith, Pete -- Sykes, Martin T -- Thonicke, Kirsten -- Thuiller, Wilfried -- Tuck, Gill -- Zaehle, Sonke -- Zierl, Barbel -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1333-7. Epub 2005 Oct 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany. dagmar.schroeter@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254151" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Biodiversity ; Carbon ; Climate ; Conservation of Natural Resources ; Crops, Agricultural ; *Ecosystem ; Environment ; Europe ; Greenhouse Effect ; Humans ; Models, Statistical ; Models, Theoretical ; Socioeconomic Factors ; Trees/growth & development ; Urban Population ; Water Supply ; Wood
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, Anthony G -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):208-9; author reply 208-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662728" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; Diet ; Edible Grain/chemistry ; Fatty Acids, Unsaturated/analysis ; Humans ; *Inflammation ; *Longevity ; Myocardial Infarction/etiology ; *Nutritional Physiological Phenomena ; Resorcinols/analysis ; Thromboxane A2/metabolism
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  • 41
    Publication Date: 2005-06-04
    Description: Unambiguous indicators of gender in dinosaurs are usually lost during fossilization, along with other aspects of soft tissue anatomy. We report the presence of endosteally derived bone tissues lining the interior marrow cavities of portions of Tyrannosaurus rex (Museum of the Rockies specimen number 1125) hindlimb elements, and we hypothesize that these tissues are homologous to specialized avian tissues known as medullary bone. Because medullary bone is unique to female birds, its discovery in extinct dinosaurs solidifies the link between dinosaurs and birds, suggests similar reproductive strategies, and provides an objective means of gender differentiation in dinosaurs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schweitzer, Mary H -- Wittmeyer, Jennifer L -- Horner, John R -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1456-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Marine, Earth, and Atmospheric Sciences, North Carolina State University, Raleigh, NC 27695, USA. schweitzer@ncsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933198" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/*anatomy & histology/ultrastructure ; Chickens/anatomy & histology ; Dinosaurs/*anatomy & histology ; Dromaiidae/anatomy & histology ; Female ; Femur/anatomy & histology ; Male ; Palaeognathae/*anatomy & histology ; Reproduction ; *Sex Characteristics ; Sex Determination Analysis ; Struthioniformes/anatomy & histology
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1410-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322433" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; Geography ; Humans ; *Pest Control
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):962-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284156" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Consciousness ; Great Britain ; History, 20th Century ; History, 21st Century ; Humans ; Neurosciences/*history ; Pain Threshold ; Politics ; Religion
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731414" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Cardiovascular Diseases/chemically induced/epidemiology ; Celecoxib ; Cyclooxygenase Inhibitors/*adverse effects/*therapeutic use ; *Drug Labeling ; Drug and Narcotic Control ; Humans ; Isoxazoles/adverse effects/therapeutic use ; Lactones/adverse effects/therapeutic use ; Pyrazoles/adverse effects/therapeutic use ; Stroke/chemically induced/epidemiology ; Sulfonamides/adverse effects/therapeutic use ; Sulfones/adverse effects/therapeutic use ; United States ; *United States Food and Drug Administration
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1883.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373542" target="_blank"〉PubMed〈/a〉
    Keywords: *Disaster Planning/economics ; *Disasters ; Humans
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  • 46
    Publication Date: 2005-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16223999" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Simulation ; Crowding ; Disaster Planning ; Escape Reaction ; *Facility Design and Construction ; Humans ; *Safety Management ; September 11 Terrorist Attacks
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Dianhua -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363028" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; United States
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1889.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373545" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dna ; DNA, Mitochondrial ; Elephants/*genetics ; Female ; History, Ancient ; Sequence Analysis, DNA/methods ; Specimen Handling
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2149.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195437" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Biomedical Research ; Female ; Humans ; Male ; *National Institutes of Health (U.S.) ; *Research Personnel ; United States ; *Women
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  • 50
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845823" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthropology, Physical ; Climate ; Emigration and Immigration ; England ; History, Ancient ; *Hominidae ; Humans ; *Paleontology ; Population Dynamics ; Time
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kueppers, Lara M -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1278-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311318" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Developing Countries ; Humans ; *Models, Theoretical
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  • 52
    Publication Date: 2005-07-16
    Description: Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect in cellular proliferation, but was correlated with the induction of apoptotic markers, particularly in tissues characterized by rapid cellular turnover. The levels of apoptotic markers were also found to increase during aging in normal mice. Thus, accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kujoth, G C -- Hiona, A -- Pugh, T D -- Someya, S -- Panzer, K -- Wohlgemuth, S E -- Hofer, T -- Seo, A Y -- Sullivan, R -- Jobling, W A -- Morrow, J D -- Van Remmen, H -- Sedivy, J M -- Yamasoba, T -- Tanokura, M -- Weindruch, R -- Leeuwenburgh, C -- Prolla, T A -- AG021905/AG/NIA NIH HHS/ -- AG16694/AG/NIA NIH HHS/ -- AG17994/AG/NIA NIH HHS/ -- AG18922/AG/NIA NIH HHS/ -- AG21042/AG/NIA NIH HHS/ -- DK48831/DK/NIDDK NIH HHS/ -- RR00095/RR/NCRR NIH HHS/ -- T32 AG00213/AG/NIA NIH HHS/ -- T32 GM07601/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):481-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020738" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Amino Acid Substitution ; Animals ; *Apoptosis ; Caspase 3 ; Caspases/metabolism ; Cloning, Molecular ; DNA Damage ; DNA Fragmentation ; DNA, Mitochondrial/*genetics ; DNA-Directed DNA Polymerase/genetics ; Gene Targeting ; Humans ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation ; Liver/metabolism ; Mice ; Mitochondria, Heart/metabolism ; Mitochondria, Liver/metabolism ; Muscle, Skeletal/metabolism ; *Mutation ; Myocardium/metabolism ; *Oxidative Stress ; Phenotype ; Presbycusis/etiology ; Reactive Oxygen Species/metabolism
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1595.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339414" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/standards ; *Cell Line ; *Cloning, Organism ; Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; *Publishing ; *Stem Cells
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):694-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051767" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Animals ; *Arthropods/physiology ; *Behavior, Animal ; *Birds/physiology ; Female ; Heteroptera/physiology ; Male ; Paternal Behavior ; Predatory Behavior ; Reproduction ; *Sexual Behavior, Animal ; *Smegmamorpha/physiology ; Spiders/physiology
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  • 55
    Publication Date: 2005-10-08
    Description: The large-scale spatial dynamics and population structure of marine top predators are poorly known. We present electronic tag and photographic identification data showing a complex suite of behavioral patterns in white sharks. These include coastal return migrations and the fastest known transoceanic return migration among swimming fauna, which provide direct evidence of a link between widely separated populations in South Africa and Australia. Transoceanic return migration involved a return to the original capture location, dives to depths of 980 meters, and the tolerance of water temperatures as low as 3.4 degrees C. These findings contradict previous ideas that female white sharks do not make transoceanic migrations, and they suggest natal homing behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonfil, Ramon -- Meyer, Michael -- Scholl, Michael C -- Johnson, Ryan -- O'Brien, Shannon -- Oosthuizen, Herman -- Swanson, Stephan -- Kotze, Deon -- Paterson, Michael -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):100-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10460, USA. rbonfil@wcs.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210537" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Identification Systems ; *Animal Migration ; Animals ; Australia ; Behavior, Animal ; Cues ; Female ; Homing Behavior ; Indian Ocean ; Male ; Population Dynamics ; Satellite Communications ; Sex Characteristics ; Sharks/*physiology ; South Africa ; Swimming ; Temperature
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):334.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831722" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/administration & dosage/adverse effects/*therapeutic use ; *Clinical Trials as Topic/standards ; Female ; HIV Infections/drug therapy/*prevention & control/*transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Institute of Medicine (U.S.) ; National Institutes of Health (U.S.) ; Nevirapine/administration & dosage/adverse effects/*therapeutic use ; Pilot Projects ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Uganda ; United States
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  • 57
    Publication Date: 2005-01-18
    Description: Although albatrosses are paradigms of oceanic specialization, their foraging areas and migration routes when not breeding remain essentially unknown. Our continuous remote tracking of 22 adult gray-headed albatrosses for over 30 bird-years reveals three distinct strategies: (i) Stay in breeding home range; (ii) make return migrations to a specific area of the southwest Indian Ocean; and (iii) make one or more global circumnavigations (the fastest in just 46 days). The consistencies in patterns, routes, and timings offer the first hope of identifying areas of critical habitat for nonbreeding albatrosses, wherein appropriate management of longline fisheries might alleviate the plight of the world's most threatened family of birds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Croxall, John P -- Silk, Janet R D -- Phillips, Richard A -- Afanasyev, Vsevolod -- Briggs, Dirk R -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):249-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge CB3 0ET, UK. jpcr@bas.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653503" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; Birds/*physiology ; Breeding ; Environment ; Female ; *Homing Behavior ; Male ; Reproduction ; Seasons ; Sex Characteristics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jorde, Lynn B -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):60-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. lbj@genetics.utah.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802591" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Alleles ; Animals ; Chromosome Mapping ; Chromosomes, Human/genetics ; Chromosomes, Mammalian/genetics ; Evolution, Molecular ; *Genome ; *Genome, Human ; Haplotypes ; Humans ; Linkage Disequilibrium ; Pan troglodytes/*genetics ; *Recombination, Genetic ; Sample Size ; Sequence Homology, Nucleic Acid
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  • 59
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kraus, Scott D -- Brown, Moira W -- Caswell, Hal -- Clark, Christopher W -- Fujiwara, Masami -- Hamilton, Philip K -- Kenney, Robert D -- Knowlton, Amy R -- Landry, Scott -- Mayo, Charles A -- McLellan, William A -- Moore, Michael J -- Nowacek, Douglas P -- Pabst, D Ann -- Read, Andrew J -- Rolland, Rosalind M -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):561-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Edgerton Research Laboratory, New England Aquarium, Boston, MA 02110-3399, USA. skraus@neaq.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040692" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Ecology ; *Ecosystem ; Environment ; Female ; Fisheries ; Male ; Mortality ; Population Dynamics ; Population Growth ; Public Policy ; Reproduction ; Ships ; *Whales/physiology
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  • 60
    Publication Date: 2005-08-27
    Description: CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peng, Guangyong -- Guo, Zhong -- Kiniwa, Yukiko -- Voo, Kui Shin -- Peng, Weiyi -- Fu, Tihui -- Wang, Daniel Y -- Li, Yanchun -- Wang, Helen Y -- Wang, Rong-Fu -- P01CA94237/CA/NCI NIH HHS/ -- P50 CA093459/CA/NCI NIH HHS/ -- P50CA58204/CA/NCI NIH HHS/ -- R01CA101795/CA/NCI NIH HHS/ -- R01CA90327/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1380-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123302" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Adoptive Transfer ; Animals ; Antigens, Differentiation/genetics/physiology ; CD4-Positive T-Lymphocytes/*immunology ; Cell Line ; Cell Line, Tumor ; Humans ; Immune Tolerance ; Interleukin-1 Receptor-Associated Kinases ; Killer Cells, Natural/immunology ; Ligands ; Lymphocyte Activation ; Membrane Glycoproteins/genetics/*physiology ; Mice ; Myeloid Differentiation Factor 88 ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology/pathology ; Oligodeoxyribonucleotides/immunology ; Phosphotransferases (Alcohol Group Acceptor)/genetics/physiology ; Poly G/immunology ; RNA Interference ; Receptors, Cell Surface/genetics/*physiology ; Receptors, Immunologic/genetics/physiology ; *Signal Transduction ; T-Lymphocyte Subsets/*immunology ; Toll-Like Receptor 8 ; Toll-Like Receptors
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  • 61
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845824" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; *Anthropology, Physical ; Asia ; Chromosomes, Human, X/*genetics ; *Genes ; Genetic Variation ; Genetics, Population ; Haplotypes ; Hominidae/*genetics ; Humans ; Hybridization, Genetic ; Sequence Analysis, DNA ; X Chromosome/*genetics
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  • 62
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1401-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Computer Simulation ; Dna ; Evolution, Molecular ; *Genome ; Humans ; Mammals/genetics ; Species Specificity
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):551-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/physiology ; Circadian Rhythm ; Female ; Gonadotropin-Releasing Hormone/physiology/secretion ; Humans ; Hypogonadism/genetics ; Kisspeptins ; Leptin/genetics/physiology ; Male ; Mutation ; Neurons/physiology ; Proteins/genetics/*physiology ; Puberty/*physiology ; Receptors, Cell Surface/genetics/metabolism ; Receptors, G-Protein-Coupled ; Receptors, Leptin ; Receptors, Neuropeptide/genetics/*physiology ; Reproduction ; Signal Transduction ; Tumor Suppressor Proteins
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  • 64
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339426" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Environment ; Financing, Government ; Great Britain ; Humans ; International Cooperation ; Nanostructures/*toxicity ; *Nanotechnology ; Occupational Exposure ; *Research ; United States
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  • 65
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1761.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axin Protein ; Body Patterning/drug effects/genetics ; *DNA Methylation ; DNA Transposable Elements ; *Dietary Supplements ; Embryonic Development/drug effects/*genetics ; *Epigenesis, Genetic ; Female ; Folic Acid/*administration & dosage/pharmacology ; Gene Expression Regulation, Developmental/*drug effects ; Mice ; Pregnancy ; Repressor Proteins/genetics ; Tail/embryology ; Vitamin B Complex/*administration & dosage/pharmacology
    Print ISSN: 0036-8075
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1533.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947148" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arvicolinae/*genetics/physiology/psychology ; *Behavior, Animal ; Female ; *Gene Expression Regulation ; Male ; *Microsatellite Repeats ; Pair Bond ; Paternal Behavior ; Receptors, Vasopressin/*genetics/metabolism ; *Social Behavior
    Print ISSN: 0036-8075
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339425" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*pharmacology ; Artemisinins/*pharmacology/therapeutic use ; Cambodia ; Cost-Benefit Analysis ; Drug Resistance ; Drug Therapy, Combination ; French Guiana ; Humans ; Malaria/drug therapy/parasitology ; Plasmodium/*drug effects ; Senegal
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Christopher N -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):255-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia. christopher.johnson@jcu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16002607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthropology ; Australia ; *Birds ; Carbon Isotopes ; Climate ; *Diet ; Dromaiidae ; *Ecosystem ; *Environment ; *Food Chain ; Humans ; *Mammals ; Marsupialia ; *Plants ; Poaceae ; Population Dynamics
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821057" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism/*legislation & jurisprudence ; Capital Punishment ; Child ; Foreign Professional Personnel/*legislation & jurisprudence ; HIV Infections/*transmission ; Humans ; Libya ; Medical Staff/*legislation & jurisprudence ; Politics
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  • 70
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Ian T -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1839.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790809" target="_blank"〉PubMed〈/a〉
    Keywords: Anticarcinogenic Agents/administration & dosage ; Developed Countries ; *Diet ; Gastrointestinal Neoplasms/*etiology/prevention & control ; Humans ; Inflammation ; Overnutrition
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821056" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Acquired Immunodeficiency Syndrome/epidemiology ; Biomedical Research/economics/legislation & jurisprudence/trends ; Crime/*legislation & jurisprudence ; Emigration and Immigration/legislation & jurisprudence ; Government Agencies ; Humans ; Libya/epidemiology ; Medical Staff ; Research/economics/legislation & jurisprudence/*trends
    Print ISSN: 0036-8075
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):721.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051780" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Pharmaceutical ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry ; Humans ; *Pharmaceutical Preparations ; Technology, Pharmaceutical
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuo, Arthur D -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1686-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Mechanical Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA. artkuo@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151001" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioelectric Energy Sources ; Biomechanical Phenomena ; *Electricity ; *Energy Metabolism ; Humans ; *Walking ; Weight-Bearing
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):602.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Proliferation/*drug effects ; Ciliary Neurotrophic Factor/*pharmacology ; Humans ; Hypothalamus/cytology/*drug effects ; Mice ; Neurons/cytology/*drug effects ; Weight Loss/*drug effects
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  • 75
    Publication Date: 2005-05-21
    Description: Gene marking with replication-defective retroviral vectors has been used for more than 20 years to track the in vivo fate of cell clones. We demonstrate that retroviral integrations themselves may trigger nonmalignant clonal expansion in murine long-term hematopoiesis. All 29 insertions recovered from clones dominating in serially transplanted recipients affected loci with an established or potential role in the self-renewal or survival of hematopoietic stem cells. Transcriptional dysregulation occurred in all 12 insertion sites analyzed. These findings have major implications for diagnostic gene marking and the discovery of genes regulating stem cell turnover.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kustikova, Olga -- Fehse, Boris -- Modlich, Ute -- Yang, Min -- Dullmann, Jochen -- Kamino, Kenji -- von Neuhoff, Nils -- Schlegelberger, Brigitte -- Li, Zhixiong -- Baum, Christopher -- New York, N.Y. -- Science. 2005 May 20;308(5725):1171-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone Marrow Transplantation, University Hospital Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905401" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD34/genetics ; Bone Marrow Transplantation ; DNA-Binding Proteins/genetics ; Down-Regulation ; *Genetic Vectors ; *Hematopoiesis ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*physiology ; Humans ; Ligase Chain Reaction ; Mice ; Mice, Inbred C57BL ; *Mutagenesis, Insertional ; Polymerase Chain Reaction ; Proto-Oncogenes/genetics ; Retroviridae/*genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transgenes ; Up-Regulation ; *Virus Integration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/cytology ; *Cell Line ; Embryo Implantation ; Embryo Research/economics/*ethics ; Embryo, Mammalian/*cytology ; Female ; Financing, Government ; Humans ; Mice ; Nuclear Transfer Techniques ; *Pluripotent Stem Cells ; Research Support as Topic ; *Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosch, Xavier -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166486" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Child ; *Clinical Trials as Topic ; *Drug Approval ; *European Union ; Humans ; *Legislation, Drug ; *Pediatrics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Evolution, Molecular ; *Genome ; *Genome, Human ; Genomics ; Humans ; Pan troglodytes/*genetics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Cooperative Behavior ; Game Theory ; Humans ; Memory ; Social Behavior
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  • 80
    Publication Date: 2005-08-16
    Description: Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LaFever, Leesa -- Drummond-Barbosa, Daniela -- GM 069875/GM/NIGMS NIH HHS/ -- R01 GM069875/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1071-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16099985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Proliferation ; Drosophila/cytology/genetics/*physiology ; Drosophila Proteins/genetics/*physiology ; Female ; Food ; Germ Cells/*cytology ; Insulin/*physiology ; Mutation ; Ovarian Follicle/cytology/physiology ; Ovary/cytology/physiology ; Peptides/physiology ; Receptor Protein-Tyrosine Kinases/genetics/physiology ; *Signal Transduction ; Stem Cells/*cytology ; Vitellogenesis
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994526" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Chromatin/physiology ; *Gene Expression Regulation ; *Genes ; *Genome, Human ; Humans ; RNA, Untranslated/genetics/physiology ; Regulatory Sequences, Nucleic Acid
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1753.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357233" target="_blank"〉PubMed〈/a〉
    Keywords: *Academic Medical Centers/economics/manpower ; Budgets ; *Disasters ; *Faculty ; Humans ; Louisiana ; *Personnel Downsizing ; *Schools, Medical/economics/manpower ; *Universities/economics/manpower
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1179.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731410" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Size ; Bone and Bones/*chemistry ; DNA/*chemistry ; *Fossils ; History, Ancient ; *Hominidae/anatomy & histology/classification/genetics ; Humans ; Indonesia ; Microcephaly/history ; Ribs ; *Sequence Analysis, DNA ; Skeleton
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradford, Barry -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994508" target="_blank"〉PubMed〈/a〉
    Keywords: Beginning of Human Life ; Christianity ; Embryo Research/*ethics ; Humans ; *Stem Cells ; United States
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):85.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Division ; Cell Nucleus/physiology ; Cloning, Organism ; Cues ; Embryo, Mammalian/cytology ; Forecasting ; *Gene Expression Regulation ; Humans ; Nuclear Transfer Techniques ; Oocytes/cytology/*physiology ; Stem Cells/cytology/*physiology
    Print ISSN: 0036-8075
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):841.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705826" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Mitochondrial/analysis ; Female ; Fossils ; Hominidae/classification/*genetics ; Humans ; *Hybridization, Genetic ; Male ; *Sexual Behavior
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):755.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272086" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Anti-Infective Agents ; *Bioterrorism ; Communicable Diseases/drug therapy ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services/*legislation & ; jurisprudence/*organization & administration ; *Vaccines
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790840" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiosis ; Archaea/genetics/*isolation & purification ; Bacteria/genetics/growth & development/*isolation & purification/metabolism ; Bacterial Infections/*microbiology ; Biofilms/growth & development ; Ecosystem ; Genes, Archaeal ; Genes, Bacterial ; Gingiva/microbiology ; Halitosis/microbiology ; Humans ; Mouth/*microbiology ; Mouth Diseases/*microbiology ; Mouthwashes ; Sequence Analysis, DNA ; Tongue/microbiology ; Tooth/microbiology
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brauer, Jurgen -- New York, N.Y. -- Science. 2005 May 6;308(5723):791-2; author reply 791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources ; *Economics ; Humans
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  • 90
    Publication Date: 2005-11-19
    Description: The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3',5'-monophosphate (cAMP), a second messenger implicated in learning, memory, and mood. We show that DISC1 interacts with the UCR2 domain of PDE4B and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and an increase in PDE4B activity. We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millar, J Kirsty -- Pickard, Benjamin S -- Mackie, Shaun -- James, Rachel -- Christie, Sheila -- Buchanan, Sebastienne R -- Malloy, M Pat -- Chubb, Jennifer E -- Huston, Elaine -- Baillie, George S -- Thomson, Pippa A -- Hill, Elaine V -- Brandon, Nicholas J -- Rain, Jean-Christophe -- Camargo, L Miguel -- Whiting, Paul J -- Houslay, Miles D -- Blackwood, Douglas H R -- Muir, Walter J -- Porteous, David J -- G8604010/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1187-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK. Kirsty.Millar@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293762" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/metabolism ; Adult ; Affective Disorders, Psychotic/genetics/metabolism ; Animals ; Cadherins/genetics ; Cell Line ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 16 ; Cyclic AMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Genetic Predisposition to Disease ; Humans ; Male ; Nerve Tissue Proteins/*genetics/metabolism ; Protein Binding ; Rats ; Schizophrenia/enzymology/*genetics/metabolism ; *Signal Transduction ; Translocation, Genetic
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  • 91
    Publication Date: 2005-12-17
    Description: Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamason, Rebecca L -- Mohideen, Manzoor-Ali P K -- Mest, Jason R -- Wong, Andrew C -- Norton, Heather L -- Aros, Michele C -- Jurynec, Michael J -- Mao, Xianyun -- Humphreville, Vanessa R -- Humbert, Jasper E -- Sinha, Soniya -- Moore, Jessica L -- Jagadeeswaran, Pudur -- Zhao, Wei -- Ning, Gang -- Makalowska, Izabela -- McKeigue, Paul M -- O'donnell, David -- Kittles, Rick -- Parra, Esteban J -- Mangini, Nancy J -- Grunwald, David J -- Shriver, Mark D -- Canfield, Victor A -- Cheng, Keith C -- CA73935/CA/NCI NIH HHS/ -- EY11308/EY/NEI NIH HHS/ -- HD37572/HD/NICHD NIH HHS/ -- HD40179/HD/NICHD NIH HHS/ -- HG002154/HG/NHGRI NIH HHS/ -- HL077910/HL/NHLBI NIH HHS/ -- RR017441/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1782-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357253" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; African Continental Ancestry Group/genetics ; Alanine/genetics ; Alleles ; Amino Acid Sequence ; Animals ; Antiporters/chemistry/*genetics/physiology ; Asian Continental Ancestry Group/genetics ; Biological Evolution ; Calcium/metabolism ; European Continental Ancestry Group/genetics ; Gene Frequency ; Genes ; Genetic Variation ; Haplotypes ; Heterozygote ; Humans ; Ion Transport ; Melanins/analysis ; Melanosomes/chemistry/ultrastructure ; Mice ; Molecular Sequence Data ; Multifactorial Inheritance ; Mutation ; Pigment Epithelium of Eye/chemistry/ultrastructure ; Polymorphism, Single Nucleotide ; Selection, Genetic ; Skin Pigmentation/*genetics ; Threonine/genetics ; Zebrafish/embryology/*genetics/metabolism ; Zebrafish Proteins/chemistry/*genetics/physiology
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):952-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284148" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*supply & distribution ; Cell Line ; *Disease Outbreaks/prevention & control ; Financing, Government ; Humans ; Influenza A Virus, H5N1 Subtype/growth & development/immunology/pathogenicity ; Influenza A virus/growth & development/immunology ; Influenza Vaccines/*economics ; Influenza, Human/drug therapy/*epidemiology/prevention & control/*virology ; United States ; Virus Cultivation
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210501" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Bioterrorism ; Chick Embryo/virology ; Containment of Biohazards ; Disease Outbreaks/history ; Editorial Policies ; *Genes, Viral ; Genome, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; History, 20th Century ; Humans ; Influenza A virus/*genetics/*pathogenicity/physiology ; Influenza, Human/epidemiology/history/*virology ; Mice ; Neuraminidase/genetics/metabolism ; Publishing ; RNA Replicase/genetics/metabolism ; United States ; Virulence ; Virus Replication
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Russell -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2007-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Auckland, Auckland 92019, New Zealand. rd.gray@auckland.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179464" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; *Cultural Evolution ; Databases, Factual ; History, Ancient ; Humans ; *Language ; *Linguistics ; Pacific Islands ; Papua New Guinea ; Software ; Time Factors
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1311.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123273" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Culture ; *Feeding Behavior ; Female ; *Imitative Behavior ; *Learning ; *Pan troglodytes/psychology ; Social Class ; Social Conformity
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  • 96
    Publication Date: 2005-09-17
    Description: The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology. By using a combination of improved low- and high-resolution conformational sampling methods, improved atomically detailed potential functions that capture the jigsaw puzzle-like packing of protein cores, and high-performance computing, high-resolution structure prediction (〈1.5 angstroms) can be achieved for small protein domains (〈85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradley, Philip -- Misura, Kira M S -- Baker, David -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1868-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Washington, Department of Biochemistry, and Howard Hughes Medical Institute, Box 357350, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166519" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemistry, Physical ; *Computational Biology ; Computer Simulation ; Hydrogen Bonding ; Models, Molecular ; Monte Carlo Method ; Physicochemical Phenomena ; *Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/*chemistry ; Sequence Alignment ; Thermodynamics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):345.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661989" target="_blank"〉PubMed〈/a〉
    Keywords: *Communicable Disease Control ; Communicable Diseases/diagnosis ; *Disasters ; *Disease Notification ; Disease Outbreaks/*prevention & control ; Epidemiologic Methods ; Humans ; India ; Indian Ocean ; Indonesia ; *Population Surveillance ; Relief Work ; Sri Lanka ; World Health Organization
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  • 98
    Publication Date: 2005-04-30
    Description: The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Steven A -- Ripperger, Juergen -- Kadener, Sebastian -- Fleury-Olela, Fabienne -- Vilbois, Francis -- Rosbash, Michael -- Schibler, Ueli -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):693-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and National Centres of Competence in Research (NCCR) Frontiers in Genetics, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland. steven.brown@molbio.unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860628" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Carrier Proteins/genetics/*metabolism ; Cell Cycle Proteins ; Cell Line ; *Circadian Rhythm ; DNA-Binding Proteins/genetics/metabolism ; Drosophila/genetics/physiology ; Drosophila Proteins/genetics/physiology ; Female ; Gene Expression Regulation ; Histones/metabolism ; Immunoprecipitation ; Male ; Methylation ; Mice ; Mice, Inbred BALB C ; Nuclear Proteins/genetics/*metabolism/physiology ; Nuclear Receptor Subfamily 1, Group D, Member 1 ; Period Circadian Proteins ; Promoter Regions, Genetic ; Proteins/genetics/*metabolism ; RNA Interference ; Rats ; Receptors, Cytoplasmic and Nuclear/genetics/metabolism ; Transcription Factors ; Transcription, Genetic ; Transfection
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1392.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933167" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain ; *Courtship ; Drosophila Proteins/*genetics/physiology ; Drosophila melanogaster ; Female ; Ganglia, Invertebrate ; Male ; Nerve Tissue Proteins/*genetics/physiology ; *RNA Splicing ; Sex Characteristics ; Sexual Behavior, Animal ; Transcription Factors/*genetics/physiology
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  • 100
    Publication Date: 2005-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greene, Mark -- Schill, Kathryn -- Takahashi, Shoji -- Bateman-House, Alison -- Beauchamp, Tom -- Bok, Hilary -- Cheney, Dorothy -- Coyle, Joseph -- Deacon, Terrence -- Dennett, Daniel -- Donovan, Peter -- Flanagan, Owen -- Goldman, Steven -- Greely, Henry -- Martin, Lee -- Miller, Earl -- Mueller, Dawn -- Siegel, Andrew -- Solter, Davor -- Gearhart, John -- McKhann, Guy -- Faden, Ruth -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):385-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Philosophy, University of Delaware, Newark, DE 19716, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020716" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Experimentation/*ethics ; Animals ; Brain/anatomy & histology/physiology ; Cell Line ; *Ethics, Research ; Humans ; Mental Processes ; Moral Obligations ; *Morals ; Neurons/cytology/physiology/*transplantation ; *Primates/psychology ; Stem Cell Transplantation/*ethics ; Transplantation Chimera ; Transplantation, Heterologous/*ethics
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