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  • Articles  (203)
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  • American Association for the Advancement of Science (AAAS)  (203)
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  • 1980-1984
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  • Articles  (203)
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  • American Association for the Advancement of Science (AAAS)  (203)
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  • 2005-2009  (203)
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  • 101
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, Ingrid -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1856-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15976282" target="_blank"〉PubMed〈/a〉
    Keywords: Autistic Disorder/pathology/*physiopathology/psychology ; Brain/pathology/*physiopathology ; Child ; Child, Preschool ; Face ; Frontal Lobe/pathology/physiopathology ; Humans ; Imitative Behavior ; Magnetic Resonance Imaging ; Male ; Memory ; *Mental Processes ; Nerve Fibers/pathology/physiology ; Neural Pathways/*physiopathology ; Neurons/pathology/*physiology ; Positron-Emission Tomography
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
    Publication Date: 2005-07-26
    Description: Hippocampal neurons were recorded under conditions in which the recording chamber was varied but its location remained unchanged versus conditions in which an identical chamber was encountered in different places. Two forms of neuronal pattern separation occurred. In the variable cue-constant place condition, the firing rates of active cells varied, often over more than an order of magnitude, whereas the location of firing remained constant. In the variable place-constant cue condition, both location and rates changed, so that population vectors for a given location in the chamber were statistically independent. These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leutgeb, Stefan -- Leutgeb, Jill K -- Barnes, Carol A -- Moser, Edvard I -- McNaughton, Bruce L -- Moser, May-Britt -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):619-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cues ; Electrodes, Implanted ; Electrophysiology ; Hippocampus/cytology/*physiology ; Interneurons/physiology ; Male ; Memory/*physiology ; Nerve Net/*physiology ; Neurons/*physiology ; Orientation/*physiology ; Perception/physiology ; Pyramidal Cells/*physiology ; Rats ; Rats, Long-Evans ; Space Perception/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
    Publication Date: 2005-06-04
    Description: Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility. These effects were transferred through the male germ line to nearly all males of all subsequent generations examined (that is, F1 to F4). The effects on reproduction correlate with altered DNA methylation patterns in the germ line. The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anway, Matthew D -- Cupp, Andrea S -- Uzumcu, Mehmet -- Skinner, Michael K -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1466-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933200" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen Antagonists/*toxicity ; Animals ; Crosses, Genetic ; DNA Methylation ; Endocrine Glands/*drug effects ; Environmental Pollutants/toxicity ; Epigenesis, Genetic/drug effects ; Estrogens/*toxicity ; Female ; Fertility/*drug effects/genetics ; Fungicides, Industrial/*toxicity ; Infertility, Male/chemically induced/genetics ; Inheritance Patterns ; Insecticides/*toxicity ; Male ; Methoxychlor/*toxicity ; Oxazoles/*toxicity ; Pregnancy ; Rats ; Spermatozoa/drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, Carol B -- Ride, Sally M -- Fouke, Janie -- Whitney, Telle -- Denton, Denice D -- Cantor, Nancy -- Nelson, Donna J -- Plummer, Jim -- Busch-Vishniac, Ilene -- Meyers, Carolyn -- Rosser, Sue V -- Schiebinger, Londa -- Roberts, Eric -- Burgess, David -- Beeson, Craig -- Metz, Susan Staffin -- Sanders, Lucinda -- Watford, Bevlee A -- Ivey, Elizabeth S -- Frank Fox, Mary -- Wettack, Sheldon -- Klawe, Maria -- Wulf, William A -- Girgus, Joan -- Leboy, Phoebe S -- Babco, Eleanor L -- Shanahan, Betty -- Didion, Catherine -- Chubin, Daryl E -- Frize, Monique -- Ganter, Susan L -- Nalley, E Ann -- Franz, Judy -- Abruna, Hector D -- Strober, Myra H -- Zimmer Daniels, Jane -- Carter, Emily A -- Rhodes, Jean H -- Schrijver, Iris -- Zakian, Virginia A -- Simons, Barbara -- Martin, Ursula -- Boaler, Jo -- Jolluck, Katherine Rose -- Mankekar, Purnima -- Gray, Robert M -- Conkey, Margaret W -- Stansky, Peter -- Xie, Aihua -- Martin, Pino -- Katehi, Linda P B -- Miller, Jo Anne -- Tess Thornton, Amelia -- Lapaugh, Andrea -- Rhode, Deborah L -- Gelpi, Barbara C -- Harrold, Mary Jean -- Spencer, Cherrill M -- Schlatter Ellis, Carla -- Lord, Susan -- Quinn, Helen -- Murnane, Margaret -- Jones, Patricia P -- Hellman, Frances -- Wight, Gail -- O'hara, Ruth -- Pickering, Mary -- Sheppard, Sheri -- Leith, David -- Paytan, Adina -- Sommer, Matthew H -- Shafer, Audrey -- Grusky, David -- Yennello, Sherry -- Madan, Ashima -- Johnson, Denise L -- Yanagisako, Sylvia -- Chou-Green, Jennifer M -- Robinson, Sandra -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1043.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718449" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Female ; Humans ; Male ; *Science ; *Sex Characteristics ; Social Change
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  • 105
    Publication Date: 2005-03-12
    Description: Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the ARMD1 locus, we tested single-nucleotide polymorphisms for association with AMD in two independent case-control populations. Significant association (P = 4.95 x 10(-10)) was identified within the regulation of complement activation locus and was centered over a tyrosine-402 --〉 histidine-402 protein polymorphism in the gene encoding complement factor H. Possession of at least one histidine at amino acid position 402 increased the risk of AMD 2.7-fold and may account for 50% of the attributable risk of AMD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, Albert O -- Ritter, Robert 3rd -- Abel, Kenneth J -- Manning, Alisa -- Panhuysen, Carolien -- Farrer, Lindsay A -- EY014467/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):421-4. Epub 2005 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ophthalmology and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center (UTSWMC), 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. albert-edwards@swbell.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761121" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Alleles ; Amino Acid Substitution ; Case-Control Studies ; Chromosomes, Human, Pair 1/genetics ; Complement Activation/genetics ; Complement Factor H/*genetics/physiology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Haplotypes ; Histidine ; Homozygote ; Humans ; Linkage Disequilibrium ; Macular Degeneration/etiology/*genetics ; Male ; Middle Aged ; Multigene Family ; *Polymorphism, Single Nucleotide ; Risk Factors ; Tyrosine
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  • 106
    Publication Date: 2005-07-26
    Description: We elucidate the mechanisms causing stability and severe resource suppression in a consumer-resource system. The consumer, the parasitoid Aphytis, rapidly controlled an experimentally induced outbreak of the resource, California red scale, an agricultural pest, and imposed a low, stable pest equilibrium. The results are well predicted by a mechanistic, independently parameterized model. The key mechanisms are widespread in nature: an invulnerable adult stage in the resource population and rapid consumer development. Stability in this biologically nondiverse agricultural system is a property of the local interaction between these two species, not of spatial processes or of the larger ecological community.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murdoch, William -- Briggs, Cheryl J -- Swarbrick, Susan -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):610-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA. murdoch@lifesci.ucsb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040706" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Citrus ; *Ecosystem ; Female ; Hemiptera/growth & development/*parasitology/*physiology ; *Host-Parasite Interactions ; Hymenoptera/growth & development/*physiology ; Longevity ; Male ; Mathematics ; Models, Biological ; Population Density ; Population Dynamics ; Sex Ratio ; Temperature
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  • 107
    Publication Date: 2005-02-26
    Description: We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans. Axonal defects consisted of swellings that accumulated abnormal amounts of microtubule-associated and molecular motor proteins, organelles, and vesicles. Impairing axonal transport by reducing the dosage of a kinesin molecular motor protein enhanced the frequency of axonal defects and increased amyloid-beta peptide levels and amyloid deposition. Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokin, Gorazd B -- Lillo, Concepcion -- Falzone, Tomas L -- Brusch, Richard G -- Rockenstein, Edward -- Mount, Stephanie L -- Raman, Rema -- Davies, Peter -- Masliah, Eliezer -- Williams, David S -- Goldstein, Lawrence S B -- EY12598/EY/NEI NIH HHS/ -- EY13408/EY/NEI NIH HHS/ -- P50 AG05131/AG/NIA NIH HHS/ -- R01 EY007042/EY/NEI NIH HHS/ -- R01 EY007042-19/EY/NEI NIH HHS/ -- R01 EY013408/EY/NEI NIH HHS/ -- R01 EY013408-02/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1282-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731448" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Alzheimer Disease/genetics/*metabolism/*pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; *Axonal Transport ; Axons/*pathology/physiology ; Basal Nucleus of Meynert/pathology ; Brain/*metabolism/*pathology ; Cells, Cultured ; Cytoplasmic Vesicles/ultrastructure ; Female ; Hippocampus ; Humans ; Kinesin/metabolism ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/genetics/metabolism ; Neurons/metabolism ; Organelles/ultrastructure ; Plaque, Amyloid/pathology ; Time Factors
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  • 108
    Publication Date: 2005-05-10
    Description: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6). The proline-to-glutamine substitution at position 112, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II and appears to alter the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winn, Michelle P -- Conlon, Peter J -- Lynn, Kelvin L -- Farrington, Merry Kay -- Creazzo, Tony -- Hawkins, April F -- Daskalakis, Nikki -- Kwan, Shu Ying -- Ebersviller, Seth -- Burchette, James L -- Pericak-Vance, Margaret A -- Howell, David N -- Vance, Jeffery M -- Rosenberg, Paul B -- R01 DK074748/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1801-4. Epub 2005 May 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. michelle.winn@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879175" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Angiotensin II/metabolism/pharmacology ; Calcium/metabolism ; Calcium Channels/chemistry/*genetics/metabolism ; Calcium Signaling ; Carbachol/pharmacology ; Cell Line ; Cell Membrane/metabolism ; Chromosomes, Human, Pair 11/genetics ; Exons ; Female ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; Glomerulosclerosis, Focal Segmental/*genetics ; Haplotypes ; Humans ; Kidney/metabolism ; Kidney Glomerulus/metabolism ; Kidney Tubules/metabolism ; Male ; *Mutation, Missense ; Patch-Clamp Techniques ; Pedigree ; Receptor, Angiotensin, Type 1/genetics/metabolism ; Sequence Analysis, DNA ; Sodium/metabolism ; TRPC Cation Channels ; Transfection ; Uridine Triphosphate/metabolism/pharmacology
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  • 109
    Publication Date: 2005-08-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1162.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16109850" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources ; Environment ; Female ; Florida ; *Hybridization, Genetic ; Inbreeding ; Male ; *Panthera/genetics ; Population Growth ; Publishing ; *Puma/genetics ; Survival Rate ; Texas
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  • 110
    Publication Date: 2005-07-26
    Description: Brilliant plumage is typical of male birds, reflecting differential enhancement of male traits when females are the limiting sex. Brighter females are thought to evolve exclusively in response to sex role reversal. The striking reversed plumage dichromatism of Eclectus roratus parrots does not fit this pattern. We quantify plumage color in this species and show that very different selection pressures are acting on males and females. Male plumage reflects a compromise between the conflicting requirements for camouflage from predators while foraging and conspicuousness during display. Females are liberated from the need for camouflage but compete for rare nest hollows.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heinsohn, Robert -- Legge, Sarah -- Endler, John A -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):617-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Resource and Environmental Studies, Australian National University, Canberra, ACT 0200 Australia. Robert.Heinsohn@anu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040708" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Animals ; *Behavior, Animal ; Color ; Competitive Behavior ; *Feathers ; Feeding Behavior ; Female ; Male ; Nesting Behavior ; Parrots/genetics/*physiology ; *Pigmentation ; Predatory Behavior ; *Selection, Genetic ; *Sex Characteristics ; Sex Ratio ; Sexual Behavior, Animal
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  • 111
    Publication Date: 2005-06-25
    Description: Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult OB neurogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ng, Kwan L -- Li, Jia-Da -- Cheng, Michelle Y -- Leslie, Frances M -- Lee, Alex G -- Zhou, Qun-Yong -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1923-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of California-Irvine (UCI), Irvine, CA 92697, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15976302" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Brain/cytology/growth & development/metabolism ; Cell Adhesion ; Cell Count ; Cell Line ; Cell Proliferation ; Cerebral Ventricles/cytology/*physiology ; Chemotactic Factors/physiology ; Chemotaxis ; Coculture Techniques ; Dopamine/physiology ; Gastrointestinal Hormones/*metabolism ; Gene Expression ; Interneurons/cytology/*physiology ; Mice ; Mice, Inbred C57BL ; Neurons/cytology/*physiology ; Neuropeptides/*metabolism ; Olfactory Bulb/*cytology/growth & development/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/genetics/metabolism ; *Signal Transduction ; Stem Cells/*physiology
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  • 112
    Publication Date: 2005-07-09
    Description: Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Long, Stephen B -- Campbell, Ernest B -- Mackinnon, Roderick -- GM43949/GM/NIGMS NIH HHS/ -- RR00862/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16002581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Electrochemistry ; Kv1.2 Potassium Channel ; Models, Molecular ; Pichia ; Potassium/chemistry ; Potassium Channels, Voltage-Gated/*chemistry ; Protein Conformation ; Protein Structure, Tertiary ; Protein Subunits/chemistry ; Rats ; Recombinant Proteins/chemistry
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  • 113
    Publication Date: 2005-02-01
    Description: The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chih, Ben -- Engelman, Holly -- Scheiffele, Peter -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681343" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cell Adhesion Molecules, Neuronal ; Cell Line ; Cells, Cultured ; Dendrites/physiology/ultrastructure ; Down-Regulation ; Evoked Potentials ; Excitatory Postsynaptic Potentials ; Hippocampus/cytology ; Membrane Proteins/genetics/*metabolism ; Membrane Transport Proteins/metabolism ; Mutation ; Nerve Tissue Proteins/genetics/*metabolism ; Neural Inhibition ; Neurons/physiology ; Presynaptic Terminals/*physiology ; Protein Isoforms ; RNA Interference ; Rats ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/*physiology ; Synaptic Membranes/*physiology ; Synaptic Transmission ; Transfection ; Vesicular Glutamate Transport Protein 1 ; Vesicular Inhibitory Amino Acid Transport Proteins
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  • 114
    Publication Date: 2005-07-09
    Description: Many patterns in biological systems depend on the exchange of chemical signals between cells. We report a spatiotemporal pattern mediated by hydrodynamic interactions. At planar surfaces, spermatozoa self-organized into dynamic vortices resembling quantized rotating waves. These vortices formed an array with local hexagonal order. Introducing an order parameter that quantifies cooperativity, we found that the array appeared only above a critical sperm density. Using a model, we estimated the hydrodynamic interaction force between spermatozoa to be approximately 0.03 piconewtons. Thus, large-scale coordination of cells can be regulated hydrodynamically, and chemical signals are not required.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riedel, Ingmar H -- Kruse, Karsten -- Howard, Jonathon -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany. riedel@mpi-cbg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16002619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biophysical Phenomena ; Biophysics ; Cell Count ; Diffusion ; Male ; Mathematics ; Models, Biological ; *Sperm Motility ; Sperm Tail/physiology ; Spermatozoa/*physiology ; Stochastic Processes ; Strongylocentrotus/*physiology ; Strongylocentrotus purpuratus/physiology
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  • 115
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nogueiras, Ruben -- Tschop, Matthias -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):985-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284170" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Appetite/drug effects ; Computational Biology ; *Eating/drug effects ; Energy Metabolism ; Fasting ; Gastric Emptying/drug effects ; Gastrointestinal Motility/drug effects ; Ghrelin ; Humans ; Mice ; Peptide Hormones/genetics/metabolism/pharmacology/*physiology ; Protein Precursors/metabolism ; Protein Processing, Post-Translational ; Rats ; Receptors, G-Protein-Coupled/genetics/metabolism ; Signal Transduction ; Stomach/metabolism ; Weight Gain/drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1754-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357234" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; African Continental Ancestry Group/genetics ; Alanine/genetics ; Alleles ; Animals ; Antiporters/chemistry/*genetics/physiology ; Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Genes ; Genetic Variation ; Humans ; Mutation ; Selection, Genetic ; Skin Pigmentation/*genetics ; Threonine/genetics ; Zebrafish/*genetics ; Zebrafish Proteins/chemistry/*genetics/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 117
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):964-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284157" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Chromosomes, Human, Y/genetics ; Cultural Evolution ; DNA, Mitochondrial/*analysis/genetics/history ; Emigration and Immigration ; Europe ; European Continental Ancestry Group/*genetics/history ; Female ; Genetics, Population ; Haplotypes ; History, Ancient ; Humans ; Male ; Population Dynamics
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  • 118
    Publication Date: 2005-12-13
    Description: Snake presynaptic phospholipase A2 neurotoxins (SPANs) paralyze the neuromuscular junction (NMJ). Upon intoxication, the NMJ enlarges and has a reduced content of synaptic vesicles, and primary neuronal cultures show synaptic swelling with surface exposure of the lumenal domain of the synaptic vesicle protein synaptotagmin I. Concomitantly, these neurotoxins induce exocytosis of neurotransmitters. We found that an equimolar mixture of lysophospholipids and fatty acids closely mimics all of the biological effects of SPANs. These results draw attention to the possible role of local lipid changes in synaptic vesicle release and provide new tools for the study of exocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rigoni, Michela -- Caccin, Paola -- Gschmeissner, Steve -- Koster, Grielof -- Postle, Anthony D -- Rossetto, Ornella -- Schiavo, Giampietro -- Montecucco, Cesare -- GP0272Y01/Telethon/Italy -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1678-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Sciences and Consiglio Nazionale Ricerche Institute of Neuroscience, University of Padova, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339444" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Elapid Venoms/toxicity ; Esterification ; Exocytosis ; Fatty Acids/*metabolism/toxicity ; Glutamic Acid/metabolism ; Hydrolysis ; Kinetics ; Lipid Bilayers ; Lysophospholipids/*metabolism/toxicity ; Male ; Mass Spectrometry ; Membrane Fusion ; Membrane Lipids/metabolism ; Mice ; Neuromuscular Junction/drug effects/metabolism/physiology ; Neurons/drug effects/metabolism/ultrastructure ; Neurotoxins/*metabolism/toxicity ; Neurotransmitter Agents/metabolism ; Phospholipases A/*metabolism/toxicity ; Phospholipases A2 ; Synapses/drug effects/ultrastructure ; Synaptic Membranes/metabolism/*physiology ; Synaptic Vesicles/drug effects/physiology/ultrastructure
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  • 119
    Publication Date: 2005-12-24
    Description: The phylogenetic relationships among most metazoan phyla remain uncertain. We obtained large numbers of gene sequences from metazoans, including key understudied taxa. Despite the amount of data and breadth of taxa analyzed, relationships among most metazoan phyla remained unresolved. In contrast, the same genes robustly resolved phylogenetic relationships within a major clade of Fungi of approximately the same age as the Metazoa. The differences in resolution within the two kingdoms suggest that the early history of metazoans was a radiation compressed in time, a finding that is in agreement with paleontological inferences. Furthermore, simulation analyses as well as studies of other radiations in deep time indicate that, given adequate sequence data, the lack of resolution in phylogenetic trees is a signature of closely spaced series of cladogenetic events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rokas, Antonis -- Kruger, Dirk -- Carroll, Sean B -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1933-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Laboratory of Molecular Biology, R. M. Bock Labs, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373569" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Computer Simulation ; DNA, Complementary ; Fungi/classification ; Genes ; Humans ; Invertebrates/classification/genetics ; Models, Biological ; Phylogeny ; Sequence Analysis, DNA ; Time
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  • 120
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zebrowitz, Leslie A -- Montepare, Joann M -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1565-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Brandeis University, Waltham, MA 02454, USA. zebrowit@brandeis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947164" target="_blank"〉PubMed〈/a〉
    Keywords: Character ; *Face/anatomy & histology ; Female ; Forecasting ; Humans ; Judgment ; Leadership ; Male ; *Mental Competency ; *Politics ; *Social Perception ; Stereotyping
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 121
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, Alex -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1814.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166500" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Art ; *Birds ; Ceremonial Behavior ; *Culture ; Female ; History, Ancient ; Humans ; *Indians, North American/history ; Male ; Population Density
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  • 122
    Publication Date: 2005-11-15
    Description: Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin-a contraction of obese, from the Latin "obedere," meaning to devour, and "statin," denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Jian V -- Ren, Pei-Gen -- Avsian-Kretchmer, Orna -- Luo, Ching-Wei -- Rauch, Rami -- Klein, Cynthia -- Hsueh, Aaron J W -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):996-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284174" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; CHO Cells ; Computational Biology ; Conserved Sequence ; Cricetinae ; *Eating/drug effects ; Fasting ; Gastric Emptying/drug effects ; Gastrointestinal Motility/drug effects ; Ghrelin ; Humans ; In Vitro Techniques ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Peptide Hormones/blood/chemistry/*genetics/metabolism/pharmacology/*physiology ; Protein Binding ; Protein Precursors/*genetics ; Radioimmunoassay ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Ghrelin ; Signal Transduction ; Weight Gain/drug effects
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  • 123
    Publication Date: 2005-11-08
    Description: Empathizing is the capacity to predict and to respond to the behavior of agents (usually people) by inferring their mental states and responding to these with an appropriate emotion. Systemizing is the capacity to predict and to respond to the behavior of nonagentive deterministic systems by analyzing input-operation-output relations and inferring the rules that govern such systems. At a population level, females are stronger empathizers and males are stronger systemizers. The "extreme male brain" theory posits that autism represents an extreme of the male pattern (impaired empathizing and enhanced systemizing). Here we suggest that specific aspects of autistic neuroanatomy may also be extremes of typical male neuroanatomy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baron-Cohen, Simon -- Knickmeyer, Rebecca C -- Belmonte, Matthew K -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):819-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Autism Research Centre, Cambridge University, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK. sb205@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272115" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/physiology ; Animals ; Asperger Syndrome/pathology/physiopathology/psychology ; Autistic Disorder/pathology/*physiopathology/psychology ; Brain/*anatomy & histology/pathology/*physiology/physiopathology ; Empathy ; Estradiol/metabolism ; Female ; Humans ; Male ; Models, Psychological ; Receptors, Androgen/metabolism ; *Sex Characteristics
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  • 124
    Publication Date: 2005-02-19
    Description: Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malsam, Jorg -- Satoh, Ayano -- Pelletier, Laurence -- Warren, Graham -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1095-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8002, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantigens/*metabolism ; Binding, Competitive ; COP-Coated Vesicles/*metabolism ; Cell Fractionation ; Cell Line ; Cytoskeletal Proteins/*metabolism ; DNA-Binding Proteins ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/chemistry/enzymology/*metabolism ; Humans ; Immunoprecipitation ; Membrane Glycoproteins/metabolism ; Membrane Proteins/*metabolism ; Microscopy, Electron ; Protein Transport ; Rats ; Recombinant Fusion Proteins/metabolism ; Transcription Factors ; Viral Envelope Proteins/metabolism
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  • 125
    Publication Date: 2005-10-22
    Description: There have been numerous recent observations of changes in the behavior and dynamics of migratory bird populations, but the plasticity of the migratory trait and our inability to track small animals over large distances have hindered investigation of the mechanisms behind migratory change. We used habitat-specific stable isotope signatures to show that recently evolved allopatric wintering populations of European blackcaps Sylvia atricapilla pair assortatively on their sympatric breeding grounds. Birds wintering further north also produce larger clutches and fledge more young. These findings describe an important process in the evolution of migratory divides, new migration routes, and wintering quarters. Temporal segregation of breeding is a way in which subpopulations of vertebrates may become isolated in sympatry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bearhop, Stuart -- Fiedler, Wolfgang -- Furness, Robert W -- Votier, Stephen C -- Waldron, Susan -- Newton, Jason -- Bowen, Gabriel J -- Berthold, Peter -- Farnsworth, Keith -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):502-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biology and Biochemistry, Medical Biological Centre, Lisburn Road, Queen's University Belfast, Belfast BT6 7BL, UK. s.bearhop@qub.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239479" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Biological Evolution ; Carbon Isotopes/analysis ; Environment ; Europe ; Female ; Hydrogen/analysis ; Isotopes ; Male ; Passeriformes/*physiology ; Regression Analysis ; *Reproduction ; Seasons ; *Sexual Behavior, Animal
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  • 126
    Publication Date: 2005-09-06
    Description: The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints among the tissues so that the brain shows the least differences between the species whereas liver shows the most. Furthermore, expression levels as well as amino acid sequences of genes active in more tissues have diverged less between the species than have genes active in fewer tissues. In general, these patterns are consistent with a model of neutral evolution with negative selection. However, for X-chromosomal genes expressed in testis, patterns suggestive of positive selection on sequence changes as well as expression changes are seen. Furthermore, although genes expressed in the brain have changed less than have genes expressed in other tissues, in agreement with previous work we find that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khaitovich, Philipp -- Hellmann, Ines -- Enard, Wolfgang -- Nowick, Katja -- Leinweber, Marcus -- Franz, Henriette -- Weiss, Gunter -- Lachmann, Michael -- Paabo, Svante -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1850-4. Epub 2005 Sep 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141373" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Amino Acid Sequence ; Animals ; Base Sequence ; Child ; Chromosomes, Human, X/genetics ; Chromosomes, Mammalian/genetics ; *Evolution, Molecular ; Female ; *Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; *Genome ; *Genome, Human ; Heart/physiology ; Humans ; Kidney/physiology ; Liver/physiology ; Male ; Middle Aged ; Models, Genetic ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Pan troglodytes/*genetics ; Prefrontal Cortex/physiology ; Promoter Regions, Genetic ; Proteins/genetics ; Selection, Genetic ; Sequence Analysis, DNA ; Species Specificity ; Testis/physiology ; *Transcription, Genetic ; X Chromosome/genetics
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  • 127
    Publication Date: 2005-11-26
    Description: Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are often highly expressed at developmental stages before miRNA expression and that their levels tend to fall as the miRNA that targets them begins to accumulate. Nonconserved sites, which outnumber the conserved sites 10 to 1, also mediate repression. As a consequence, genes preferentially expressed at the same time and place as a miRNA have evolved to selectively avoid sites matching the miRNA. This phenomenon of selective avoidance extends to thousands of genes and enables spatial and temporal specificities of miRNAs to be revealed by finding tissues and developmental stages in which messages with corresponding sites are expressed at lower levels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farh, Kyle Kai-How -- Grimson, Andrew -- Jan, Calvin -- Lewis, Benjamin P -- Johnston, Wendy K -- Lim, Lee P -- Burge, Christopher B -- Bartel, David P -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1817-21. Epub 2005 Nov 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16308420" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Differentiation ; Conserved Sequence ; *Evolution, Molecular ; Gene Expression Profiling ; *Gene Expression Regulation ; Humans ; Mammals/*genetics ; Mice ; MicroRNAs/*metabolism ; Molecular Sequence Data ; Muscle Fibers, Skeletal/cytology/metabolism ; Organ Specificity ; RNA Stability ; RNA, Messenger/*genetics/metabolism ; Rats ; Species Specificity ; Untranslated Regions ; Zebrafish/genetics
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  • 128
    Publication Date: 2005-02-01
    Description: Bats make up more than 20% of extant mammals, yet their evolutionary history is largely unknown because of a limited fossil record and conflicting or incomplete phylogenies. Here, we present a highly resolved molecular phylogeny for all extant bat families. Our results support the hypothesis that megabats are nested among four major microbat lineages, which originated in the early Eocene [52 to 50 million years ago (Mya)], coincident with a significant global rise in temperature, increase in plant diversity and abundance, and the zenith of Tertiary insect diversity. Our data suggest that bats originated in Laurasia, possibly in North America, and that three of the major microbat lineages are Laurasian in origin, whereas the fourth is Gondwanan. Combining principles of ghost lineage analysis with molecular divergence dates, we estimate that the bat fossil record underestimates (unrepresented basal branch length, UBBL) first occurrences by, on average, 73% and that the sum of missing fossil history is 61%.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teeling, Emma C -- Springer, Mark S -- Madsen, Ole -- Bates, Paul -- O'brien, Stephen J -- Murphy, William J -- N01-CO-12400/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):580-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genomic Diversity, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, MD 21702, USA. emma.teeling@ucd.ie〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681385" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; Asia ; Bayes Theorem ; Biodiversity ; Biological Evolution ; Chiroptera/anatomy & histology/*classification/*genetics/physiology ; Echolocation ; Europe ; Flight, Animal ; *Fossils ; Genes ; Geography ; Likelihood Functions ; North America ; *Phylogeny ; Plants ; Sequence Analysis, DNA ; South America ; Temperature ; Time
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  • 129
    Publication Date: 2005-09-24
    Description: Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated mouse embryonic stem cells and generated a trans-species aneuploid mouse line that stably transmits a freely segregating, almost complete human chromosome 21 (Hsa21). This "transchromosomic" mouse line, Tc1, is a model of trisomy 21, which manifests as Down syndrome (DS) in humans, and has phenotypic alterations in behavior, synaptic plasticity, cerebellar neuronal number, heart development, and mandible size that relate to human DS. Transchromosomic mouse lines such as Tc1 may represent useful genetic tools for dissecting other human aneuploidies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1378183/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1378183/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, Aideen -- Ruf, Sandra -- Mulligan, Claire -- Hildreth, Victoria -- Errington, Mick L -- Cooke, Sam -- Sesay, Abdul -- Modino, Sonie -- Vanes, Lesley -- Hernandez, Diana -- Linehan, Jacqueline M -- Sharpe, Paul T -- Brandner, Sebastian -- Bliss, Timothy V P -- Henderson, Deborah J -- Nizetic, Dean -- Tybulewicz, Victor L J -- Fisher, Elizabeth M C -- 076700/Wellcome Trust/United Kingdom -- MC_U117512674/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2033-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179473" target="_blank"〉PubMed〈/a〉
    Keywords: *Aneuploidy ; Animals ; Behavior, Animal ; Brain/pathology ; Cell Count ; Cell Line ; Chimera ; *Chromosomes, Human, Pair 21 ; *Disease Models, Animal ; *Down Syndrome/genetics/physiopathology ; Embryo, Mammalian/cytology ; Facial Bones/pathology ; Female ; Gene Expression ; *Genetic Engineering ; Genetic Markers ; Heart Defects, Congenital/embryology ; Hippocampus/physiopathology ; Humans ; Long-Term Potentiation ; Lymphocyte Activation ; Male ; Maze Learning ; Memory ; Mice ; Mice, Inbred Strains ; *Mice, Transgenic ; Neurons/cytology ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Skull/pathology ; Stem Cells ; Synaptic Transmission ; T-Lymphocytes/immunology
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  • 130
    Publication Date: 2005-10-08
    Description: Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal experience, stereotypes with a "kernel of truth," or inaccurate stereotypes. We obtained national character ratings of 3989 people from 49 cultures and compared them with the average personality scores of culture members assessed by observer ratings and self-reports. National character ratings were reliable but did not converge with assessed traits. Perceptions of national character thus appear to be unfounded stereotypes that may serve the function of maintaining a national identity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775052/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775052/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terracciano, A -- Abdel-Khalek, A M -- Adam, N -- Adamovova, L -- Ahn, C-k -- Ahn, H-n -- Alansari, B M -- Alcalay, L -- Allik, J -- Angleitner, A -- Avia, M D -- Ayearst, L E -- Barbaranelli, C -- Beer, A -- Borg-Cunen, M A -- Bratko, D -- Brunner-Sciarra, M -- Budzinski, L -- Camart, N -- Dahourou, D -- De Fruyt, F -- de Lima, M P -- del Pilar, G E H -- Diener, E -- Falzon, R -- Fernando, K -- Fickova, E -- Fischer, R -- Flores-Mendoza, C -- Ghayur, M A -- Gulgoz, S -- Hagberg, B -- Halberstadt, J -- Halim, M S -- Hrebickova, M -- Humrichouse, J -- Jensen, H H -- Jocic, D D -- Jonsson, F H -- Khoury, B -- Klinkosz, W -- Knezevic, G -- Lauri, M A -- Leibovich, N -- Martin, T A -- Marusic, I -- Mastor, K A -- Matsumoto, D -- McRorie, M -- Meshcheriakov, B -- Mortensen, E L -- Munyae, M -- Nagy, J -- Nakazato, K -- Nansubuga, F -- Oishi, S -- Ojedokun, A O -- Ostendorf, F -- Paulhus, D L -- Pelevin, S -- Petot, J-M -- Podobnik, N -- Porrata, J L -- Pramila, V S -- Prentice, G -- Realo, A -- Reategui, N -- Rolland, J-P -- Rossier, J -- Ruch, W -- Rus, V S -- Sanchez-Bernardos, M L -- Schmidt, V -- Sciculna-Calleja, S -- Sekowski, A -- Shakespeare-Finch, J -- Shimonaka, Y -- Simonetti, F -- Sineshaw, T -- Siuta, J -- Smith, P B -- Trapnell, P D -- Trobst, K K -- Wang, L -- Yik, M -- Zupancic, A -- McCrae, R R -- Z99 AG999999/Intramural NIH HHS/ -- ZIA AG000180-25/Intramural NIH HHS/ -- ZIA AG000180-26/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):96-100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute on Aging, NIH, DHHS, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. terraccianoa@grc.nia.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210536" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Character ; Cross-Cultural Comparison ; *Culture ; *Ethnic Groups ; Female ; Humans ; Male ; *Personality ; Personality Assessment ; Reproducibility of Results ; Social Perception ; Stereotyping ; Surveys and Questionnaires
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  • 131
    Publication Date: 2005-02-26
    Description: Loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) is an epigenetic alteration that results in a modest increase in IGF2 expression, and it is present in the normal colonic mucosa of about 30% of patients with colorectal cancer. To investigate its role in intestinal tumorigenesis, we created a mouse model of Igf2 LOI by crossing female H19+/- mice with male Apc+/Min mice. Mice with LOI developed twice as many intestinal tumors as did control littermates. Notably, these mice also showed a shift toward a less differentiated normal intestinal epithelium, reflected by an increase in crypt length and increased staining with progenitor cell markers. A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sakatani, Takashi -- Kaneda, Atsushi -- Iacobuzio-Donahue, Christine A -- Carter, Mark G -- de Boom Witzel, Sten -- Okano, Hideyuki -- Ko, Minoru S H -- Ohlsson, Rolf -- Longo, Dan L -- Feinberg, Andrew P -- K08CA106610/CA/NCI NIH HHS/ -- R01CA65145/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1976-8. Epub 2005 Feb 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731405" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/etiology/pathology ; Animals ; Apoptosis ; Cell Differentiation ; Cell Proliferation ; Colon/cytology/metabolism ; Colonic Neoplasms/etiology/pathology ; Enterocytes/*cytology/metabolism ; Ephrin-B1/analysis ; Epigenesis, Genetic ; Female ; *Genomic Imprinting ; Humans ; Insulin-Like Growth Factor II/*genetics/*metabolism ; Intestinal Mucosa/*cytology/metabolism ; Intestinal Neoplasms/*etiology/pathology ; Intestines/*metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/analysis ; Nerve Tissue Proteins/analysis ; Nuclear Proteins/analysis ; RNA, Long Noncoding ; RNA, Untranslated/genetics ; RNA-Binding Proteins/analysis ; Stem Cells/cytology ; Transcription Factors/analysis ; Twist Transcription Factor
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  • 132
    Publication Date: 2005-07-16
    Description: In everyday life, the successful monitoring of behavior requires continuous updating of the effectiveness of motor acts; one crucial step is becoming aware of the movements one is performing. We studied the anatomical distribution of lesions in right-brain-damaged hemiplegic patients, who obstinately denied their motor impairment, claiming that they could move their paralyzed limbs. Denial was associated with lesions in areas related to the programming of motor acts, particularly Brodmann's premotor areas 6 and 44, motor area 4, and the somatosensory cortex. This association suggests that monitoring systems may be implemented within the same cortical network that is responsible for the primary function that has to be monitored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berti, A -- Bottini, G -- Gandola, M -- Pia, L -- Smania, N -- Stracciari, A -- Castiglioni, I -- Vallar, G -- Paulesu, E -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):488-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Psychology Department and Center for Cognitive Science, University of Turin, Via Po 14, 10123 Turin, Italy. berti@psych.unito.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020740" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; *Awareness ; Brain Damage, Chronic/pathology/*physiopathology ; Brain Mapping ; Frontal Lobe/pathology/physiopathology ; Hemiplegia/*physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity ; Motor Cortex/pathology/*physiopathology ; Movement ; Nerve Net/physiology ; Perceptual Disorders/pathology/*physiopathology ; Prefrontal Cortex/pathology/physiopathology ; Somatosensory Cortex/*physiopathology
    Print ISSN: 0036-8075
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  • 133
    Publication Date: 2005-04-30
    Description: The ivory-billed woodpecker (Campephilus principalis), long suspected to be extinct, has been rediscovered in the Big Woods region of eastern Arkansas. Visual encounters during 2004 and 2005, and analysis of a video clip from April 2004, confirm the existence of at least one male. Acoustic signatures consistent with Campephilus display drums also have been heard from the region. Extensive efforts to find birds away from the primary encounter site remain unsuccessful, but potential habitat for a thinly distributed source population is vast (over 220,000 hectares).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitzpatrick, John W -- Lammertink, Martjan -- Luneau, M David Jr -- Gallagher, Tim W -- Harrison, Bobby R -- Sparling, Gene M -- Rosenberg, Kenneth V -- Rohrbaugh, Ronald W -- Swarthout, Elliott C H -- Wrege, Peter H -- Swarthout, Sara Barker -- Dantzker, Marc S -- Charif, Russell A -- Barksdale, Timothy R -- Remsen, J V Jr -- Simon, Scott D -- Zollner, Douglas -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1460-2. Epub 2005 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cornell Laboratory of Ornithology, Cornell University, 159 Sapsucker Woods Road, Ithaca, NY 14850, USA. jwf7@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arkansas ; Biological Evolution ; *Birds ; Conservation of Natural Resources ; Ecology ; Male ; Video Recording
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  • 134
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):618-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860602" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Cervical Intraepithelial Neoplasia/prevention & control ; Clinical Trials as Topic ; Condylomata Acuminata/prevention & control ; Developed Countries ; Developing Countries ; Drug Approval ; Drug Industry ; Female ; Humans ; Immunization Programs ; Male ; Papillomaviridae/*immunology ; Papillomavirus Infections/*prevention & control/transmission ; Uterine Cervical Neoplasms/*prevention & control/*virology ; Vaccines, Synthetic ; *Viral Vaccines/administration & dosage/adverse effects/immunology
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  • 135
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: For more than two decades, researchers have argued that young children do not understand mental states such as beliefs. Part of the evidence for this claim comes from preschoolers' failure at verbal tasks that require the understanding that others may hold false beliefs. Here, we used a novel nonverbal task to examine 15-month-old infants' ability to predict an actor's behavior on the basis of her true or false belief about a toy's hiding place. Results were positive, supporting the view that, from a young age, children appeal to mental states--goals, perceptions, and beliefs--to explain the behavior of others.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357322/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357322/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onishi, Kristine H -- Baillargeon, Renee -- 1 T32MH19990/MH/NIMH NIH HHS/ -- HD-21104/HD/NICHD NIH HHS/ -- R01 HD021104/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):255-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada. kris.onishi@mcgill.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821091" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; *Child Development ; *Comprehension ; Female ; Humans ; Infant ; Male ; *Mental Processes ; Psychology, Child ; Psychology, Social
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  • 136
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):624-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatin/metabolism/ultrastructure ; DNA-Directed RNA Polymerases/metabolism ; Dosage Compensation, Genetic ; Drosophila/genetics ; Drosophila Proteins/chemistry/genetics/*physiology ; *Gene Expression Regulation, Developmental ; *Gene Silencing ; Histones/metabolism ; Humans ; Male ; Methylation ; Mutation ; Neoplasms/etiology/genetics ; Nucleosomes/ultrastructure ; Pluripotent Stem Cells/physiology ; Polycomb Repressive Complex 1 ; Polycomb-Group Proteins ; Prostatic Neoplasms/genetics/metabolism/pathology ; Proteins/genetics/metabolism ; Repressor Proteins/chemistry/genetics/*physiology ; Transcription, Genetic ; Ubiquitin/metabolism
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  • 137
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1547.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761131" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*prevention & control ; Amyloid beta-Peptides/*metabolism ; Animals ; Brain/*metabolism ; Exercise ; Gene Expression ; Housing, Animal ; Humans ; Learning ; Male ; Memory ; Mice ; Neprilysin/metabolism ; *Physical Conditioning, Animal ; Plaque, Amyloid/*metabolism ; Risk
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  • 138
    Publication Date: 2005-07-30
    Description: Classical fear conditioning investigates how animals learn to associate environmental stimuli with an aversive event. We examined how the mechanisms of fear conditioning apply when humans learn to associate social ingroup and outgroup members with a fearful event, with the goal of advancing our understanding of basic learning theory and social group interaction. Primates more readily associate stimuli from certain fear-relevant natural categories, such as snakes, with a negative outcome relative to stimuli from fear-irrelevant categories, such as birds. We assessed whether this bias in fear conditioning extends to social groups defined by race. Our results indicate that individuals from a racial group other than one's own are more readily associated with an aversive stimulus than individuals of one's own race, among both white and black Americans. This prepared fear response might be reduced by close, positive interracial contact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsson, Andreas -- Ebert, Jeffrey P -- Banaji, Mahzarin R -- Phelps, Elizabeth A -- 1RO1MH57672/MH/NIMH NIH HHS/ -- 5R01MH068447/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):785-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, New York University, 6 Washington Place, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051800" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/*psychology ; Attitude ; Biological Evolution ; *Conditioning (Psychology) ; Culture ; European Continental Ancestry Group/*psychology ; Extinction, Psychological ; Face ; Fear/*psychology ; Female ; Galvanic Skin Response ; Humans ; Interpersonal Relations ; *Learning ; Male ; *Prejudice ; Social Behavior ; Social Distance ; Stereotyping
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  • 139
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kondro, Wayne -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1405.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322427" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare/*legislation & jurisprudence ; Animals ; Biomedical Research/legislation & jurisprudence ; Canada ; Laboratories ; Rats ; Schools, Medical/legislation & jurisprudence ; *Students ; Universities/*legislation & jurisprudence
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  • 140
    Publication Date: 2005-03-19
    Description: The efficacy and short-term modification of neocortical synaptic connections vary with the type of target neuron. We investigated presynaptic Ca2+ and release probability at single synaptic contacts between pairs of neurons in layer 2/3 of the rat neocortex. The amplitude of Ca2+ signals in boutons of pyramids contacting bitufted or multipolar interneurons or other pyramids was dependent on the target cell type. Optical quantal analysis at single synaptic contacts suggested that release probabilities are also target cell-specific. Both the Ca2+ signal and the release probability of different boutons of a pyramid contacting the same target cell varied little. We propose that the mechanisms that regulate the functional properties of boutons of a pyramid normalize the presynaptic Ca2+ influx and release probability for all those boutons that innervate the same target cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koester, Helmut J -- Johnston, Daniel -- MH44754/MH/NIMH NIH HHS/ -- MH48432/MH/NIMH NIH HHS/ -- NNS37444/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 May 6;308(5723):863-6. Epub 2005 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Abteilung Zellphysiologie, Max-Planck-Institut fur Medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany. HKoester@mail.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774725" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Axons/physiology ; Calcium/*metabolism ; Calcium Signaling ; Dendrites/physiology ; Excitatory Postsynaptic Potentials ; Fluorescence ; In Vitro Techniques ; Interneurons/*physiology ; Models, Neurological ; Neuronal Plasticity ; Neurotransmitter Agents/*metabolism ; Patch-Clamp Techniques ; Presynaptic Terminals/physiology ; Probability ; Pyramidal Cells/*physiology ; Rats ; Rats, Wistar ; Somatosensory Cortex/cytology/*physiology ; Synapses/*physiology
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  • 141
    Publication Date: 2005-05-10
    Description: To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced. These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schriner, Samuel E -- Linford, Nancy J -- Martin, George M -- Treuting, Piper -- Ogburn, Charles E -- Emond, Mary -- Coskun, Pinar E -- Ladiges, Warren -- Wolf, Norman -- Van Remmen, Holly -- Wallace, Douglas C -- Rabinovitch, Peter S -- AG001751/AG/NIA NIH HHS/ -- AG13280/AG/NIA NIH HHS/ -- ES07033/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1909-11. Epub 2005 May 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879174" target="_blank"〉PubMed〈/a〉
    Keywords: Aconitate Hydratase/metabolism ; *Aging ; Animals ; Arteriosclerosis/pathology ; Catalase/genetics/*metabolism ; Cataract/pathology ; Cell Nucleus/enzymology/metabolism ; DNA/chemistry ; Deoxyguanosine/*analogs & derivatives/analysis ; Female ; Free Radicals ; Heart Diseases/pathology ; Humans ; Hydrogen Peroxide/*metabolism ; *Longevity ; Male ; Mice ; Mice, Transgenic ; Mitochondria/enzymology/*metabolism ; Mitochondria, Heart/enzymology/*metabolism ; Muscle, Skeletal/chemistry ; Myocardium/chemistry/pathology ; Oxidation-Reduction ; Oxidative Stress ; Peroxisomes/enzymology ; Reactive Oxygen Species/*metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Superoxide Dismutase/genetics/metabolism
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  • 142
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1760-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357240" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus/*genetics ; *Diet ; *Epigenesis, Genetic ; *Family ; Fathers ; Female ; Food Supply ; Humans ; Life Style ; Male ; *Mortality ; Overweight/*genetics ; Risk Factors ; Sex Characteristics ; *Smoking ; Time Factors
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  • 143
    Publication Date: 2005-05-14
    Description: Canary song is hierarchically structured: Short stereotyped syllables are repeated to form phrases, which in turn are arranged to form songs. This structure occurs even in the songs of young isolates, which suggests that innate rules govern canary song development. However, juveniles that had never heard normal song imitated abnormal synthetic songs with great accuracy, even when the tutor songs lacked phrasing. As the birds matured, imitated songs were reprogrammed to form typical canary phrasing. Thus, imitation and innate song constraints are separate processes that can be segregated in time: freedom in youth, rules in adulthood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gardner, Timothy J -- Naef, Felix -- Nottebohm, Fernando -- MH18343/MH/NIMH NIH HHS/ -- MH63132/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 May 13;308(5724):1046-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Animal Behavior, Rockefeller University, New York, NY 10021, USA. tgardner@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890887" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Canaries/growth & development/*physiology ; Female ; *Imitative Behavior ; *Learning ; Male ; Memory ; Sexual Maturation ; Testosterone/pharmacology ; *Vocalization, Animal
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  • 144
    Publication Date: 2005-11-08
    Description: In mammalian excitatory neurons, dendritic spines are separated from dendrites by thin necks. Diffusion across the neck limits the chemical and electrical isolation of each spine. We found that spine/dendrite diffusional coupling is heterogeneous and uncovered a class of diffusionally isolated spines. The barrier to diffusion posed by the neck and the number of diffusionally isolated spines is bidirectionally regulated by neuronal activity. Furthermore, coincident synaptic activation and postsynaptic action potentials rapidly restrict diffusion across the neck. The regulation of diffusional coupling provides a possible mechanism for determining the amplitude of postsynaptic potentials and the accumulation of plasticity-inducing molecules within the spine head.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloodgood, Brenda L -- Sabatini, Bernardo L -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):866-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272125" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cytoplasm/physiology ; Dendrites/*physiology ; Dendritic Spines/*physiology ; Diffusion ; Excitatory Postsynaptic Potentials ; Fluorescence ; GABA-A Receptor Antagonists ; Glutamic Acid/metabolism ; Green Fluorescent Proteins/metabolism ; Hippocampus/physiology ; Neurons/*physiology ; Organ Culture Techniques ; Patch-Clamp Techniques ; Pyramidal Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/antagonists & inhibitors/metabolism ; Receptors, GABA-A/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism ; Synapses/*physiology ; Synaptic Transmission ; Transfection ; Viscosity
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  • 145
    Publication Date: 2005-05-21
    Description: A distinct species of mangabey was independently found at two sites 370 kilometers apart in southern Tanzania (Mount Rungwe and Livingstone in the Southern Highlands and Ndundulu in the Udzungwa Mountains). This new species is described here and given the name "highland mangabey" Lophocebus kipunji sp. nov. We place this monkey in Lophocebus, because it possesses noncontrasting black eyelids and is arboreal. L. kipunji is distinguished from other mangabeys by the color of its pelage; long, upright crest; off-white tail and ventrum; and loud call. This find has implications for primate evolution, African biogeography, and forest conservation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Trevor -- Ehardt, Carolyn L -- Butynski, Thomas M -- Davenport, Tim R B -- Mpunga, Noah E -- Machaga, Sophy J -- De Luca, Daniela W -- New York, N.Y. -- Science. 2005 May 20;308(5725):1161-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Udzungwa Mountains National Park, Box 99, Mang'ula, Tanzania. tembomkubwa@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905399" target="_blank"〉PubMed〈/a〉
    Keywords: Altitude ; Animals ; Biodiversity ; Body Size ; Cercocebus/anatomy & histology/*classification ; Conservation of Natural Resources ; Environment ; Geography ; Male ; Population Density ; Tanzania ; Temperature ; Terminology as Topic ; Trees ; Vocalization, Animal
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  • 146
    Publication Date: 2005-01-08
    Description: Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1alphaP), a potent human immunodeficiency virus-1 (HIV-1)-suppressive chemokine and ligand for the HIV coreceptor CCR5. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This susceptibility is even greater in individuals who also possess disease-accelerating CCR5 genotypes. This relationship between CCL3L1 dose and altered HIV/AIDS susceptibility points to a central role for CCL3L1 in HIV/AIDS pathogenesis and indicates that differences in the dose of immune response genes may constitute a genetic basis for variable responses to infectious diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez, Enrique -- Kulkarni, Hemant -- Bolivar, Hector -- Mangano, Andrea -- Sanchez, Racquel -- Catano, Gabriel -- Nibbs, Robert J -- Freedman, Barry I -- Quinones, Marlon P -- Bamshad, Michael J -- Murthy, Krishna K -- Rovin, Brad H -- Bradley, William -- Clark, Robert A -- Anderson, Stephanie A -- O'connell, Robert J -- Agan, Brian K -- Ahuja, Seema S -- Bologna, Rosa -- Sen, Luisa -- Dolan, Matthew J -- Ahuja, Sunil K -- AI043279/AI/NIAID NIH HHS/ -- AI046326/AI/NIAID NIH HHS/ -- MH069270/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1434-40. Epub 2005 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Veterans Administration Research Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637236" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Chemokines, CC/*genetics/metabolism ; Child ; Cohort Studies ; Continental Population Groups/genetics ; Disease Progression ; Ethnic Groups/genetics ; Female ; *Gene Dosage ; *Gene Duplication ; *Genetic Predisposition to Disease ; Genotype ; HIV Infections/epidemiology/*genetics/*immunology/virology ; *HIV-1/metabolism ; Humans ; Male ; Middle Aged ; Pan troglodytes/genetics ; Phenotype ; Public Health ; Receptors, CCR5/genetics/metabolism ; Selection, Genetic
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  • 147
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: In birds and other vertebrates, most acoustic signals are produced pneumatically by moving air through a vocal apparatus. Here we describe a unique mechanism used to produce a tonal acoustic signal in vertebrates. Video recordings of the courtship displays of male Club-winged Manakins, Machaeropterus deliciosus, reveal that males produce sustained harmonic tones through interactions among oscillating secondary wing feathers. This mechanism of sound production shows morphological and mechanistic convergence with arthropod stridulation. Intersexual selection for production of a nonvocal courtship song has led to major morphological, functional, and likely physiological modifications in the wing of this flying bird.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bostwick, Kimberly S -- Prum, Richard O -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):736.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14850, USA. ksb6@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051789" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Biological Evolution ; Biomechanical Phenomena ; Feathers/anatomy & histology/*physiology ; Male ; Movement ; Passeriformes/anatomy & histology/*physiology ; *Sexual Behavior, Animal ; *Sound ; Video Recording ; Wings, Animal/anatomy & histology/*physiology
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  • 148
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-21
    Description: Two distinct forms of consolidated associative memory are known in Drosophila: long-term memory and so-called anesthesia-resistant memory. Long-term memory is more stable, but unlike anesthesia-resistant memory, its formation requires protein synthesis. We show that flies induced to form long-term memory become more susceptible to extreme stress (such as desiccation). In contrast, induction of anesthesia-resistant memory had no detectable effect on desiccation resistance. This finding may help to explain why evolution has maintained anesthesia-resistant memory as another form of consolidated memory, distinct from long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mery, Frederic -- Kawecki, Tadeusz J -- New York, N.Y. -- Science. 2005 May 20;308(5725):1148.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Ecology and Evolution, Department of Biology, University of Fribourg, Chemin du Musee 10, CH-1700 Fribourg, Switzerland. frederic.mery@unifr.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905396" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Conditioning (Psychology) ; Drosophila Proteins/biosynthesis ; Drosophila melanogaster/*physiology ; Female ; Male ; Memory/*physiology ; Odors ; Starvation ; Water Deprivation
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  • 149
    Publication Date: 2005-08-06
    Description: The brain keenly depends on glucose for energy, and mammalians have redundant systems to control glucose production. An increase in circulating glucose inhibits glucose production in the liver, but this negative feedback is impaired in type 2 diabetes. Here we report that a primary increase in hypothalamic glucose levels lowers blood glucose through inhibition of glucose production in rats. The effect of glucose requires its conversion to lactate followed by stimulation of pyruvate metabolism, which leads to activation of adenosine triphosphate (ATP)-sensitive potassium channels. Thus, interventions designed to enhance the hypothalamic sensing of glucose may improve glucose homeostasis in diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lam, Tony K T -- Gutierrez-Juarez, Roger -- Pocai, Alessandro -- Rossetti, Luciano -- AG 21654/AG/NIA NIH HHS/ -- DK 20541/DK/NIDDK NIH HHS/ -- DK 45024/DK/NIDDK NIH HHS/ -- DK 48321/DK/NIDDK NIH HHS/ -- T32-AG023475/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):943-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine and Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081739" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/metabolism ; Blood Glucose/*metabolism ; Citric Acid Cycle ; Feedback, Physiological ; Glucose/administration & dosage/*metabolism ; Glucose-6-Phosphatase/metabolism ; Hypothalamus/*metabolism ; Injections, Intraventricular ; Lactic Acid/metabolism ; Liver/*metabolism ; Male ; Neurons/metabolism ; Potassium Channels/metabolism ; Pyruvates/*metabolism ; Rats ; Rats, Sprague-Dawley
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  • 150
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210503" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/*pharmacology ; Axons/drug effects/*physiology ; Cells, Cultured ; Erlotinib Hydrochloride ; Mice ; Nerve Crush ; *Nerve Regeneration/drug effects ; Neurons/drug effects/physiology ; Optic Nerve Injuries/drug therapy ; Quinazolines/*pharmacology ; Rats ; Receptor, Epidermal Growth Factor/*antagonists & inhibitors/metabolism ; Signal Transduction/*drug effects ; Spinal Cord Injuries/drug therapy
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  • 151
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graves, Jennifer A Marshall -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):50-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia. jenny.graves@anu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637257" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chromosomes/physiology ; Drosophila/*genetics ; Female ; Gene Dosage ; Genes, Insect ; Genome ; Male ; X Chromosome/genetics/physiology ; Y Chromosome/*genetics/*physiology
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  • 152
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 May 20;308(5725):1096-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905368" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Blastocyst/*cytology ; Cell Line ; Child ; Child, Preschool ; *Cloning, Organism/ethics/methods ; Embryo Research/ethics ; Female ; Humans ; Korea ; Male ; Middle Aged ; Oocytes ; Politics ; *Research Embryo Creation/ethics/methods ; *Stem Cells ; Tissue Donors ; United States
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  • 153
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):422.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239449" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Diethylhexyl Phthalate/metabolism/*toxicity ; Female ; Genitalia, Male/*drug effects ; Humans ; Male ; National Institutes of Health (U.S.)/organization & administration ; Phthalic Acids/*toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects ; Sexual Development/*drug effects ; Toxicity Tests ; United States
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  • 154
    Publication Date: 2005-11-26
    Description: The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)-activated protein kinase]. The deletion of LKB1 in the liver of adult mice resulted in a nearly complete loss of AMPK activity. Loss of LKB1 function resulted in hyperglycemia with increased gluconeogenic and lipogenic gene expression. In LKB1-deficient livers, TORC2, a transcriptional coactivator of CREB (cAMP response element-binding protein), was dephosphorylated and entered the nucleus, driving the expression of peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), which in turn drives gluconeogenesis. Adenoviral small hairpin RNA (shRNA) for TORC2 reduced PGC-1alpha expression and normalized blood glucose levels in mice with deleted liver LKB1, indicating that TORC2 is a critical target of LKB1/AMPK signals in the regulation of gluconeogenesis. Finally, we show that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074427/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074427/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, Reuben J -- Lamia, Katja A -- Vasquez, Debbie -- Koo, Seung-Hoi -- Bardeesy, Nabeel -- Depinho, Ronald A -- Montminy, Marc -- Cantley, Lewis C -- CA84313/CA/NCI NIH HHS/ -- GM056203/GM/NIGMS NIH HHS/ -- GM37828/GM/NIGMS NIH HHS/ -- R01 GM056203/GM/NIGMS NIH HHS/ -- R01 GM056203-09/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. shaw@salk.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16308421" target="_blank"〉PubMed〈/a〉
    Keywords: AMP-Activated Protein Kinases ; Animals ; Blood Glucose/analysis ; Diabetes Mellitus, Type 2/drug therapy/metabolism ; Enzyme Activation ; Female ; Gene Expression Regulation ; Gluconeogenesis/genetics ; Glucose/*metabolism ; HeLa Cells ; Homeostasis ; Humans ; Hyperglycemia/drug therapy/metabolism ; Hypoglycemic Agents/*pharmacology/therapeutic use ; Lipogenesis/genetics ; Liver/enzymology/*metabolism ; Male ; Metformin/*pharmacology/therapeutic use ; Mice ; Mice, Obese ; Multienzyme Complexes/*metabolism ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics/*metabolism ; Signal Transduction ; Trans-Activators/genetics/metabolism ; Transcription Factors
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  • 155
    Publication Date: 2005-10-08
    Description: Shark populations are declining globally, yet the movements and habitats of most species are unknown. We used a satellite tag attached to the dorsal fin to track salmon sharks (Lamna ditropis) for up to 3.2 years. Here we show that salmon sharks have a subarctic-to-subtropical niche, ranging from 2 degrees to 24 degrees C, and they spend winter periods in waters as cold as 2 degrees to 8 degrees C. Functional assays and protein gels reveal that the expression of excitation-contraction coupling proteins is enhanced in salmon shark hearts, which may underlie the shark's ability to maintain heart function at cold temperatures and their niche expansion into subarctic seas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weng, Kevin C -- Castilho, Pedro C -- Morrissette, Jeffery M -- Landeira-Fernandez, Ana M -- Holts, David B -- Schallert, Robert J -- Goldman, Kenneth J -- Block, Barbara A -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):104-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tuna Research and Conservation Center, Stanford University, Hopkins Marine Station, 120 Oceanview Boulevard, Pacific Grove, CA 93950, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210538" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization ; Animal Identification Systems ; Animal Migration ; Animals ; Behavior, Animal ; Body Temperature ; Calcium/metabolism ; Calcium-Transporting ATPases/metabolism ; Cold Temperature ; Ecosystem ; *Environment ; Female ; Heart/*physiology ; Heart Ventricles/metabolism ; Male ; Myocardial Contraction ; Myocardium/*metabolism ; Pacific Ocean ; Predatory Behavior ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Satellite Communications ; Seasons ; Sharks/*physiology ; Swimming ; Temperature
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  • 156
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: In mammals, X-inactivation establishes X-chromosome dosage parity between males and females. How X-chromosome counting regulates this process remains elusive, because neither the hypothesized inactivation "blocking factor" nor the required cis-elements have been defined. Here, a mouse knockout and transgenic analysis identified DNA sequences within the noncoding Tsix and Xite genes as numerators. Homozygous deficiency of Tsix resulted in "chaotic choice" and a variable number of inactive X's, whereas overdosage of Tsix/Xite inhibited X-inactivation. Thus, counting was affected by specific Tsix/Xite mutations, suggesting that counting is genetically separable from but molecularly coupled to choice. The mutations affect XX and XY cells differently, demonstrating that counting and choice are regulated not by one "blocking factor," but by both a "blocking" and a "competence" factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Jeannie T -- R01-GM58839/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):768-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School Boston, MA 02114, USA. lee@molbio.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051795" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Blastocyst ; Cell Death ; Cell Differentiation ; Cell Line ; Chromosomes, Mammalian/genetics ; *DNA, Intergenic ; *Dosage Compensation, Genetic ; Female ; Gene Dosage ; Gene Silencing ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Models, Genetic ; RNA, Long Noncoding ; RNA, Untranslated/*genetics/physiology ; X Chromosome/*genetics
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  • 157
    Publication Date: 2005-03-26
    Description: Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonnenburg, Justin L -- Xu, Jian -- Leip, Douglas D -- Chen, Chien-Huan -- Westover, Benjamin P -- Weatherford, Jeremy -- Buhler, Jeremy D -- Gordon, Jeffrey I -- DK052574/DK/NIDDK NIH HHS/ -- DK30292/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1955-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences, Washington University, St. Louis, MO 63108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790854" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Bacterial Proteins/*genetics/metabolism ; Bacteroides/enzymology/genetics/growth & development/*metabolism ; Cecum/*microbiology ; Cluster Analysis ; Diet ; Dietary Carbohydrates/metabolism ; Ecosystem ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Germ-Free Life ; Glycoside Hydrolases/genetics/metabolism ; Hexoses/metabolism ; Intestines/microbiology ; Male ; Mice ; Mucus/metabolism ; Oligonucleotide Array Sequence Analysis ; Operon ; Polysaccharide-Lyases/genetics/metabolism ; Polysaccharides/*metabolism ; *Symbiosis ; Transcription, Genetic ; Up-Regulation
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  • 158
    Publication Date: 2005-06-18
    Description: Hippocampal place cells are a model system of how the brain constructs cognitive representations and of how these representations support complex behavior, learning, and memory. There is, however, a lack of detailed knowledge about the properties of hippocampal afferents. We recorded multiple single units from the hippocampus and the medial and lateral entorhinal areas of behaving rats. Although many medial entorhinal neurons had highly specific place fields, lateral entorhinal neurons displayed weak spatial specificity. This finding demonstrates a fundamental dissociation between the information conveyed to the hippocampus by its major input streams, with spatial information represented by the medial and nonspatial information represented by the lateral entorhinal cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hargreaves, Eric L -- Rao, Geeta -- Lee, Inah -- Knierim, James J -- K02 MH63297/MH/NIMH NIH HHS/ -- R01 NS039456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1792-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, Post Office Box 20708, University of Texas Medical School at Houston, Houston, TX 77225, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961670" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Brain Mapping ; Cues ; Electrodes, Implanted ; Entorhinal Cortex/*physiology ; Hippocampus/*physiology ; Learning/*physiology ; Male ; Neural Pathways ; Neurons/*physiology ; Pyramidal Cells/physiology ; Rats ; Rats, Long-Evans
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  • 159
    Publication Date: 2005-05-28
    Description: Mechanisms that protect against asthma remain poorly understood. S-nitrosoglutathione (GSNO), an endogenous bronchodilator, is depleted from asthmatic airways, suggesting a protective role. We report that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs). In contrast, mice with genetic deletion of GSNOR exhibit increases in lung SNOs and are protected from airway hyperresponsivity. Our results indicate that endogenous SNOs, governed by GSNOR, are critical regulators of airway responsivity and may provide new therapeutic approaches to asthma.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128762/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128762/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Que, Loretta G -- Liu, Limin -- Yan, Yun -- Whitehead, Gregory S -- Gavett, Stephen H -- Schwartz, David A -- Stamler, Jonathan S -- ES012496/ES/NIEHS NIH HHS/ -- HL004171/HL/NHLBI NIH HHS/ -- K08 HL004171/HL/NHLBI NIH HHS/ -- K08 HL004171-05/HL/NHLBI NIH HHS/ -- P01 ES012496/ES/NIEHS NIH HHS/ -- P01 ES012496-010004/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1618-21. Epub 2005 May 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919956" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic beta-Agonists/pharmacology ; Alcohol Dehydrogenase ; Allergens ; Animals ; Asthma/drug therapy/*physiopathology ; Bronchi ; Bronchial Hyperreactivity/drug therapy/physiopathology ; Bronchodilator Agents ; Female ; Glutathione Reductase/genetics/*metabolism ; Homeostasis ; Imines/pharmacology ; Isoproterenol/pharmacology ; Lung/metabolism/*physiopathology ; Male ; Methacholine Chloride/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide ; Nitric Oxide Synthase/antagonists & inhibitors/metabolism ; Nitric Oxide Synthase Type II ; Ovalbumin ; S-Nitrosoglutathione/*metabolism/pharmacology ; S-Nitrosothiols/*metabolism ; Trachea/drug effects/physiology
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  • 160
    Publication Date: 2005-08-27
    Description: During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caudron, Maiwen -- Bunt, Gertrude -- Bastiaens, Philippe -- Karsenti, Eric -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1373-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Biophysics Department, European Molecular Biology Laboratory (EMBL), EMBL, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123300" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle Proteins/metabolism ; Centrosome/metabolism ; Chromatin/metabolism ; Chromosomes/*metabolism ; Cues ; Diffusion ; Guanine Nucleotide Exchange Factors/metabolism ; Guanosine Triphosphate/metabolism ; Male ; Mathematics ; Metaphase ; Microscopy, Fluorescence ; Microtubules/*metabolism ; *Mitosis ; Nuclear Proteins/metabolism ; Oocytes ; Recombinant Proteins/metabolism ; *Signal Transduction ; Spermatozoa ; Spindle Apparatus/*metabolism ; Xenopus laevis ; beta Karyopherins/*metabolism ; ran GTP-Binding Protein/*metabolism
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  • 161
    Publication Date: 2005-10-15
    Description: Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, Simon -- Bottolo, Leonardo -- Freeman, Colin -- McVean, Gil -- Donnelly, Peter -- U54 HG2750/HG/NHGRI NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):321-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16224025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Chromosome Mapping ; Chromosomes, Human ; Evolution, Molecular ; Female ; *Genome, Human ; Humans ; Male ; Models, Genetic ; Polymorphism, Single Nucleotide ; Recombination, Genetic/*genetics
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  • 162
    Publication Date: 2005-05-10
    Description: Memories are thought to be attractor states of neuronal representations, with the hippocampus a likely substrate for context-dependent episodic memories. However, such states have not been directly observed. For example, the hippocampal place cell representation of location was previously found to respond continuously to changes in environmental shape alone. We report that exposure to novel square and circular environments made of different materials creates attractor representations for both shapes: Place cells abruptly and simultaneously switch between representations as environmental shape changes incrementally. This enables study of attractor dynamics in a cognitive representation and may correspond to the formation of distinct contexts in context-dependent memory.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680068/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680068/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wills, Tom J -- Lever, Colin -- Cacucci, Francesca -- Burgess, Neil -- O'Keefe, John -- 071248/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 May 6;308(5723):873-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879220" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Cues ; Environment ; Form Perception ; Hippocampus/*cytology/*physiology ; Learning ; Memory/*physiology ; Orientation ; Pattern Recognition, Visual ; Pyramidal Cells/*physiology ; Rats ; Space Perception
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  • 163
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathans, Jeremy -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1742.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961653" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/metabolism/*pharmacology ; Amino Acid Sequence ; Animals ; Cell Death/drug effects ; Dopamine/physiology ; Humans ; Mice ; Neurons/*drug effects/metabolism ; Parkinsonian Disorders/chemically induced ; Rats ; Substantia Nigra/drug effects/metabolism ; Tyrosine 3-Monooxygenase/*chemistry/genetics/metabolism
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  • 164
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ranta, Esa -- Kaitala, Veijo -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):365-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Integrative Ecology Unit of the Department of Biological and Environmental Sciences, University of Helsinki, FIN-00014 Helsinki, Finland. esa.ranta@helsinki.fi〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; *Ecosystem ; Female ; *Lions/physiology ; Male ; Population Density ; Population Dynamics ; Predatory Behavior ; Reproduction ; Social Behavior ; Tanzania ; *Territoriality
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  • 165
    Publication Date: 2005-02-05
    Description: We describe two male-specific olfactory receptors (ORs) in the silk moth, Bombyx mori, that are mutually exclusively expressed in a pair of adjacent pheromone-sensitive neurons of male antennae: One is specifically tuned to bombykol, the sex pheromone, and the other to bombykal, its oxidized form. Both pheromone ORs are coexpressed with an OR from the highly conserved insect OR subfamily. This coexpression promotes the functional expression of pheromone receptors and confers ligand-stimulated nonselective cation channel activity. The same effects were also observed for general ORs. Both odorant and pheromone signaling pathways are mediated by means of a common mechanism in insects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakagawa, Takao -- Sakurai, Takeshi -- Nishioka, Takaaki -- Touhara, Kazushige -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1638-42. Epub 2005 Feb 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15692016" target="_blank"〉PubMed〈/a〉
    Keywords: Alkadienes/metabolism/*pharmacology ; Animals ; Bombyx/genetics/*physiology ; Cations/metabolism ; Dose-Response Relationship, Drug ; Fatty Alcohols/metabolism/*pharmacology ; Female ; Genes, Insect ; In Situ Hybridization ; Insect Proteins/genetics/*physiology ; Ion Channels/physiology ; Ligands ; Male ; Molecular Sequence Data ; Odors ; Olfactory Receptor Neurons/physiology ; Patch-Clamp Techniques ; Receptors, Odorant/genetics/*physiology ; Sense Organs/physiology ; Sex Attractants/*pharmacology/*physiology ; Signal Transduction ; Xenopus laevis
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  • 166
    Publication Date: 2005-01-22
    Description: In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wisloff, Ulrik -- Najjar, Sonia M -- Ellingsen, Oyvind -- Haram, Per Magnus -- Swoap, Steven -- Al-Share, Qusai -- Fernstrom, Mats -- Rezaei, Khadijeh -- Lee, Sang Jun -- Koch, Lauren Gerard -- Britton, Steven L -- DK 54254/DK/NIDDK NIH HHS/ -- DK 57497/DK/NIDDK NIH HHS/ -- HL 64270/HL/NHLBI NIH HHS/ -- RR 17718/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662013" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue ; Aerobiosis ; Aging ; Animals ; Blood Pressure ; Body Weight ; Breeding ; Cardiovascular Diseases/*etiology/physiopathology ; Disease Models, Animal ; Endothelium, Vascular/physiology ; Exercise ; *Exercise Tolerance ; Female ; Glucose Tolerance Test ; Humans ; Hypertension/etiology/physiopathology ; Insulin/blood ; Insulin Resistance ; Lipids/blood ; Male ; Metabolic Syndrome X/etiology/physiopathology ; Mitochondria, Muscle/metabolism/*physiology ; Muscle, Skeletal/enzymology/metabolism ; Oxidation-Reduction ; Oxygen Consumption ; PPAR gamma/metabolism ; Physical Conditioning, Animal ; *Physical Exertion ; Rats ; Risk Factors ; Running ; Selection, Genetic ; Trans-Activators/metabolism ; Ventricular Function, Left
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  • 167
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ratnieks, Francis L W -- Wenseleers, Tom -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):54-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Apiculture & Social Insects, Department of Animal & Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637260" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ants/*physiology ; Bees/*physiology ; *Behavior, Animal ; *Biological Evolution ; Female ; Male ; Oviposition ; Reproduction ; Social Behavior ; Wasps/*physiology
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  • 168
    Publication Date: 2005-11-08
    Description: Polycomb transcriptional silencing machinery is implicated in the maintenance of precursor fates, but how this repression is reversed to allow cell differentiation is unknown. Here we show that testis-specific TAF (TBP-associated factor) homologs required for terminal differentiation of male germ cells may activate target gene expression in part by counteracting repression by Polycomb. Chromatin immunoprecipitation revealed that testis TAFs bind to target promoters, reduce Polycomb binding, and promote local accumulation of H3K4me3, a mark of Trithorax action. Testis TAFs also promoted relocalization of Polycomb Repression Complex 1 components to the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Xin -- Hiller, Mark -- Sancak, Yasemin -- Fuller, Margaret T -- 1RO1GM61986/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):869-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272126" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Nucleolus/metabolism ; Chromatin Immunoprecipitation ; Drosophila/*cytology/genetics/physiology ; Drosophila Proteins/*metabolism ; *Gene Expression Regulation, Developmental ; Male ; Polycomb Repressive Complex 1 ; *Promoter Regions, Genetic ; Protein Binding ; Recombinant Fusion Proteins/metabolism ; Spermatocytes/*cytology/*metabolism ; Spermatogenesis ; TATA-Binding Protein Associated Factors/*metabolism ; Testis/metabolism ; Transcription, Genetic
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  • 169
    Publication Date: 2005-03-26
    Description: Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human chromosomes were mapped at 5-base pair resolution in eight cell lines. Unannotated, nonpolyadenylated transcripts comprise the major proportion of the transcriptional output of the human genome. Of all transcribed sequences, 19.4, 43.7, and 36.9% were observed to be polyadenylated, nonpolyadenylated, and bimorphic, respectively. Half of all transcribed sequences are found only in the nucleus and for the most part are unannotated. Overall, the transcribed portions of the human genome are predominantly composed of interlaced networks of both poly A+ and poly A- annotated transcripts and unannotated transcripts of unknown function. This organization has important implications for interpreting genotype-phenotype associations, regulation of gene expression, and the definition of a gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheng, Jill -- Kapranov, Philipp -- Drenkow, Jorg -- Dike, Sujit -- Brubaker, Shane -- Patel, Sandeep -- Long, Jeffrey -- Stern, David -- Tammana, Hari -- Helt, Gregg -- Sementchenko, Victor -- Piccolboni, Antonio -- Bekiranov, Stefan -- Bailey, Dione K -- Ganesh, Madhavan -- Ghosh, Srinka -- Bell, Ian -- Gerhard, Daniela S -- Gingeras, Thomas R -- New York, N.Y. -- Science. 2005 May 20;308(5725):1149-54. Epub 2005 Mar 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Affymetrix Inc., Santa Clara, CA 95051, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790807" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Chromosomes, Human/*genetics ; Chromosomes, Human, Pair 13/genetics ; Chromosomes, Human, Pair 14/genetics ; Chromosomes, Human, Pair 19/genetics ; Chromosomes, Human, Pair 20/genetics ; Chromosomes, Human, Pair 21/genetics ; Chromosomes, Human, Pair 22/genetics ; Chromosomes, Human, Pair 6/genetics ; Chromosomes, Human, Pair 7/genetics ; Chromosomes, Human, X/genetics ; Chromosomes, Human, Y/genetics ; Computational Biology ; Cytosol/metabolism ; DNA, Complementary ; DNA, Intergenic ; Exons ; Female ; *Genome, Human ; Humans ; Introns ; Male ; Molecular Sequence Data ; Nucleic Acid Amplification Techniques ; Oligonucleotide Array Sequence Analysis ; Physical Chromosome Mapping ; RNA Splicing ; RNA, Messenger/*analysis ; *Transcription, Genetic
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  • 170
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Pingxi -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):798-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Neuroscience and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. pingxi.xu@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272108" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Awards and Prizes ; Biochemistry/history ; China ; Drosophila/genetics/*physiology ; Drosophila Proteins/metabolism/*physiology ; Female ; History, 21st Century ; Male ; Mutation ; Olfactory Receptor Neurons/physiology ; Pheromones/metabolism/pharmacology/*physiology ; Receptors, Odorant/genetics/metabolism/*physiology ; *Signal Transduction ; United States
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  • 171
    Publication Date: 2005-10-15
    Description: Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nisoli, Enzo -- Tonello, Cristina -- Cardile, Annalisa -- Cozzi, Valeria -- Bracale, Renata -- Tedesco, Laura -- Falcone, Sestina -- Valerio, Alessandra -- Cantoni, Orazio -- Clementi, Emilio -- Moncada, Salvador -- Carruba, Michele O -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):314-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy. enzo.nisoli@unimi.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16224023" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/metabolism ; Animals ; *Caloric Restriction ; DNA, Mitochondrial/metabolism ; Enzyme Induction ; Female ; GTP Phosphohydrolases/biosynthesis ; Life Expectancy ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/*physiology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/*biosynthesis/genetics ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Oxygen Consumption ; Protein Biosynthesis ; Sirtuin 1 ; Sirtuins/biosynthesis
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  • 172
    Publication Date: 2005-01-08
    Description: Molecular dependence of vesicular endocytosis was investigated with capacitance measurements at the calyx of Held terminal in brainstem slices. Intraterminal loading of botulinum toxin E revealed that the rapid capacitance transient implicated as "kiss-and-run" was unrelated to transmitter release. The release-related capacitance change decayed with an endocytotic time constant of 10 to 25 seconds, depending on the magnitude of exocytosis. Presynaptic loading of the nonhydrolyzable guanosine 5'-triphosphate (GTP) analog GTPgS or dynamin-1 proline-rich domain peptide abolished endocytosis. These compounds had no immediate effect on exocytosis, but caused a use-dependent rundown of exocytosis. Thus, the guanosine triphosphatase dynamin-1 is indispensable for vesicle endocytosis at this fast central nervous system (CNS) synapse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamashita, Takayuki -- Hige, Toshihide -- Takahashi, Tomoyuki -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):124-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113-0033, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Botulinum Toxins/metabolism ; Brain Stem/*metabolism ; Calcium/metabolism ; Dynamin I/pharmacology/*physiology ; Electric Capacitance ; *Endocytosis ; Excitatory Postsynaptic Potentials ; Exocytosis ; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology ; Guanosine Diphosphate/*analogs & derivatives/pharmacology ; Guanosine Triphosphate/*metabolism ; Hydrolysis ; In Vitro Techniques ; Patch-Clamp Techniques ; Peptide Fragments/pharmacology ; Rats ; Rats, Wistar ; Synapses/*physiology ; Synaptic Transmission ; Synaptic Vesicles/*metabolism ; Thionucleotides/pharmacology
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  • 173
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):613.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254163" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Burial/*history ; Capital Punishment/*history ; Child ; Christianity/history ; Criminal Law/history ; Decapitation/history ; England ; History, Ancient ; Humans ; Male ; Roman World/*history
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  • 174
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1848-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790811" target="_blank"〉PubMed〈/a〉
    Keywords: Bisexuality ; Cluster Analysis ; Disease Notification/*legislation & jurisprudence ; *Disease Outbreaks ; *Ethics, Medical ; Europe/epidemiology ; Homosexuality, Male ; Humans ; Legislation, Medical ; Lymphogranuloma Venereum/*epidemiology ; Male ; Netherlands/epidemiology ; *Publishing
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  • 175
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1574.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947170" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animals ; Antisocial Personality Disorder/etiology/physiopathology ; Attention Deficit Disorder with Hyperactivity/etiology/physiopathology ; Brain/*physiology/physiopathology ; Fear ; Female ; Gonadal Steroid Hormones/physiology ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Impulsive Behavior ; Male ; *Mental Disorders/epidemiology/etiology/physiopathology ; Mental Processes ; Pituitary-Adrenal System/physiology ; *Sex Characteristics ; Stress, Physiological/physiopathology
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  • 176
    Publication Date: 2005-09-10
    Description: We have developed the suspended-load backpack, which converts mechanical energy from the vertical movement of carried loads (weighing 20 to 38 kilograms) to electricity during normal walking [generating up to 7.4 watts, or a 300-fold increase over previous shoe devices (20 milliwatts)]. Unexpectedly, little extra metabolic energy (as compared to that expended carrying a rigid backpack) is required during electricity generation. This is probably due to a compensatory change in gait or loading regime, which reduces the metabolic power required for walking. This electricity generation can help give field scientists, explorers, and disaster-relief workers freedom from the heavy weight of replacement batteries and thereby extend their ability to operate in remote areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rome, Lawrence C -- Flynn, Louis -- Goldman, Evan M -- Yoo, Taeseung D -- AR38404/AR/NIAMS NIH HHS/ -- AR46125/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1725-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. lrome@sas.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151012" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioelectric Energy Sources ; Biomechanical Phenomena ; Carbon Dioxide/metabolism ; *Electricity ; *Energy Metabolism ; Gait ; Humans ; Male ; Oxygen Consumption ; *Walking ; *Weight-Bearing
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  • 177
    Publication Date: 2005-06-18
    Description: Nepalese porters routinely carry head-supported loads equal to 100 to 200% of their body weight (Mb) for many days up and down steep mountain footpaths at high altitudes. Previous studies have shown that African women carry head-supported loads of up to 60% of their Mb far more economically than army recruits carrying equivalent loads in backpacks. Here we show that Nepalese porters carry heavier loads even more economically than African women. Female Nepalese porters, for example, carry on average loads that are 10% of their Mb heavier than the maximum loads carried by the African women, yet do so at a 25% smaller metabolic cost.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bastien, Guillaume J -- Schepens, Benedicte -- Willems, Patrick A -- Heglund, Norman C -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1755.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite de Physiologie et Biomecanique de la Locomotion, Faculte de Medecine, Universite catholique de Louvain, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961662" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Altitude ; Biomechanical Phenomena ; *Body Weight ; Carbon Dioxide ; *Energy Metabolism ; Female ; Head ; Humans ; *Lifting ; Male ; Middle Aged ; Nepal ; Oxygen Consumption ; Physical Endurance ; *Physical Exertion ; *Walking ; *Weight-Bearing
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  • 178
    Publication Date: 2005-04-12
    Description: Although a growing body of work supports the plausibility of sympatric speciation in animals, the practical difficulties of directly quantifying reproductive isolation between diverging taxa remain an obstacle to analyzing this process. We used a combination of genetic and biogeochemical markers to produce a direct field estimate of assortative mating in phytophagous insect populations. We show that individuals of the same insect species, the European corn borer Ostrinia nubilalis, that develop on different host plants can display almost absolute reproductive isolation-the proportion of assortative mating was 〉95%-even in the absence of temporal or spatial isolation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malausa, Thibaut -- Bethenod, Marie-Therese -- Bontemps, Arnaud -- Bourguet, Denis -- Cornuet, Jean-Marie -- Ponsard, Sergine -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):258-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire Dynamique de la Biodiversite, Universite P. Sabatier-Toulouse III, UMR CNRS 5172, 31 062 Toulouse Cedex 04, France. malausa@cict.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821092" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Feeding Behavior ; Female ; Male ; Moths/classification/genetics/*physiology ; *Sexual Behavior, Animal ; Zea mays
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  • 179
    Publication Date: 2005-11-19
    Description: Craniofacial abnormalities account for about one-third of all human congenital defects, but our understanding of the genetic mechanisms governing craniofacial development is incomplete. We show that GTF2IRD1 is a genetic determinant of mammalian craniofacial and cognitive development, and we implicate another member of the TFII-I transcription factor family, GTF2I, in both aspects. Gtf2ird1-null mice exhibit phenotypic abnormalities reminiscent of the human microdeletion disorder Williams-Beuren syndrome (WBS); craniofacial imaging reveals abnormalities in both skull and jaws that may arise through misregulation of goosecoid, a downstream target of Gtf2ird1. In humans, a rare WBS individual with an atypical deletion, including GTF2IRD1, shows facial dysmorphism and cognitive deficits that differ from those of classic WBS cases. We propose a mechanism of cumulative dosage effects of duplicated and diverged genes applicable to other human chromosomal disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tassabehji, May -- Hammond, Peter -- Karmiloff-Smith, Annette -- Thompson, Pamela -- Thorgeirsson, Snorri S -- Durkin, Marian E -- Popescu, Nicholas C -- Hutton, Timothy -- Metcalfe, Kay -- Rucka, Agnes -- Stewart, Helen -- Read, Andrew P -- Maconochie, Mark -- Donnai, Dian -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1184-7. Epub 2005 Nov 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Academic Unit of Medical Genetics, University of Manchester, St. Mary's Hospital, Manchester M13 9PL, UK. m.tassabehji@manchester.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293761" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Cell Line ; Child ; Child, Preschool ; Chromosomes, Human, Pair 7 ; Craniofacial Abnormalities/*genetics ; Face/*embryology ; Female ; Gene Deletion ; Goosecoid Protein/genetics/physiology ; Homozygote ; Humans ; Infant ; Infant, Newborn ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Muscle Proteins/*physiology ; Nuclear Proteins/*physiology ; Skull/*embryology ; Trans-Activators/*physiology ; Transcription Factors, TFII/physiology ; Williams Syndrome/*genetics
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  • 180
    Publication Date: 2005-06-04
    Description: The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelling nematodes, which are ubiquitous in their distribution worldwide. Here, we show that an increase in the rate of epithelial cell turnover in the large intestine acts like an "epithelial escalator" to expel Trichuris and that the rate of epithelial cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10. This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cliffe, Laura J -- Humphreys, Neil E -- Lane, Thomas E -- Potten, Chris S -- Booth, Cath -- Grencis, Richard K -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1463-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933199" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Chemokine CXCL10 ; Chemokines, CXC/immunology ; Chronic Disease ; Disease Models, Animal ; Female ; Interleukin-13/immunology ; Interleukin-4/immunology ; Intestinal Diseases, Parasitic/*immunology ; Intestinal Mucosa/cytology/*parasitology/physiology ; Intestine, Large/cytology/*parasitology/physiology ; Male ; Mice ; Mice, Inbred AKR ; Mice, Inbred BALB C ; Trichuriasis/*immunology ; Trichuris/physiology
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  • 181
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berkley, Karen J -- Rapkin, Andrea J -- Papka, Raymond E -- R01 NS11892/NS/NINDS NIH HHS/ -- R01 NS22526/NS/NINDS NIH HHS/ -- R21 DK063937/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1587-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Central Nervous System/*physiology ; Endometriosis/drug therapy/*physiopathology ; Female ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Neural Pathways ; Neurons/*physiology ; Neurons, Afferent/physiology ; Pain/*physiopathology ; Rats ; Spinal Cord/physiology ; Sympathetic Nervous System/physiology
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  • 182
    Publication Date: 2005-05-21
    Description: Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to be of great biomedical importance for studies of disease and development and to advance clinical deliberations regarding stem cell transplantation. Eleven hESC lines were established by somatic cell nuclear transfer (SCNT) of skin cells from patients with disease or injury into donated oocytes. These lines, nuclear transfer (NT)-hESCs, grown on human feeders from the same NT donor or from genetically unrelated individuals, were established at high rates, regardless of NT donor sex or age. NT-hESCs were pluripotent, chromosomally normal, and matched the NT patient's DNA. The major histocompatibility complex identity of each NT-hESC when compared to the patient's own showed immunological compatibility, which is important for eventual transplantation. With the generation of these NT-hESCs, evaluations of genetic and epigenetic stability can be made. Additional work remains to be done regarding the development of reliable directed differentiation and the elimination of remaining animal components. Before clinical use of these cells can occur, preclinical evidence is required to prove that transplantation of differentiated NT-hESCs can be safe, effective, and tolerated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, Woo Suk -- Roh, Sung Il -- Lee, Byeong Chun -- Kang, Sung Keun -- Kwon, Dae Kee -- Kim, Sue -- Kim, Sun Jong -- Park, Sun Woo -- Kwon, Hee Sun -- Lee, Chang Kyu -- Lee, Jung Bok -- Kim, Jin Mee -- Ahn, Curie -- Paek, Sun Ha -- Chang, Sang Sik -- Koo, Jung Jin -- Yoon, Hyun Soo -- Hwang, Jung Hye -- Hwang, Youn Young -- Park, Ye Soo -- Oh, Sun Kyung -- Kim, Hee Sun -- Park, Jong Hyuk -- Moon, Shin Yong -- Schatten, Gerald -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1777-83. Epub 2005 May 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. hwangws@snu.ac.kr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905366" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Agammaglobulinemia ; Blastocyst/*cytology ; Cell Differentiation ; *Cell Line ; Child ; Child, Preschool ; *Cloning, Organism ; DNA Fingerprinting ; Diabetes Mellitus, Type 1 ; Epigenesis, Genetic ; Ethics Committees, Research ; Female ; Fibroblasts ; HLA Antigens/analysis ; Humans ; Informed Consent ; Karyotyping ; Male ; *Nuclear Transfer Techniques ; Oocyte Donation ; Pluripotent Stem Cells/*cytology/immunology ; Spinal Cord Injuries ; Stem Cell Transplantation ; Tissue and Organ Procurement
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  • 183
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16223990" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Chromosome Inversion ; *Chromosomes, Human, Pair 13 ; Gene Deletion ; Humans ; Male ; Membrane Proteins/*genetics ; Nerve Tissue Proteins/*genetics ; Sequence Analysis, DNA ; Tourette Syndrome/*genetics
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  • 184
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-03
    Description: Theoretical models have shown that speciation with gene flow can occur readily via a "one-allele mechanism," where the spread of the same allele within both of two diverging species reduces their subsequent hybridization. Here we present direct genetic evidence for such an allele in Drosophila pseudoobscura. Alleles conferring high or low assortative mating in D. pseudoobscura produce the same effects when inserted into D. persimilis. This observation suggests that the type of genetic variation that is most conducive to controversial modes of speciation with gene flow, such as reinforcement or sympatric speciation, is present in nature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ortiz-Barrientos, Daniel -- Noor, Mohamed A F -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1467.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. dortizba@indiana.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322450" target="_blank"〉PubMed〈/a〉
    Keywords: *Alleles ; Animals ; Directed Molecular Evolution ; Drosophila/*genetics ; *Evolution, Molecular ; Female ; Gene Flow ; Genes, Insect ; Male ; Sexual Behavior, Animal
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  • 185
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1185.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731415" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/virology ; Anti-HIV Agents/*pharmacology/therapeutic use ; CD4 Lymphocyte Count ; Disease Progression ; Drug Resistance, Multiple, Viral ; HIV/*drug effects/*pathogenicity ; HIV Infections/drug therapy/*physiopathology/transmission/*virology ; Humans ; Male ; Time Factors ; Virulence
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  • 186
    Publication Date: 2005-10-01
    Description: When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (approximately 15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Massimini, Marcello -- Ferrarelli, Fabio -- Huber, Reto -- Esser, Steve K -- Singh, Harpreet -- Tononi, Giulio -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2228-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195466" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Cerebral Cortex/*physiology ; Computer Simulation ; Consciousness/*physiology ; Electric Stimulation ; Electroencephalography ; Evoked Potentials ; Humans ; Magnetics ; Male ; Models, Neurological ; Sleep/*physiology ; Software ; Wakefulness/physiology
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  • 187
    Publication Date: 2005-01-08
    Description: Many herbivores and omnivores adjust their food selection behavior to regulate the intake of multiple nutrients. Carnivores, however, are generally assumed to optimize the rate of prey capture rather than select prey according to nutrient composition. We showed experimentally that invertebrate predators can forage selectively for protein and lipids to redress specific nutritional imbalances. This selection can take place at different stages of prey handling: The predator may select among foods of different nutritional composition, eat more of a prey if it is rich in nutrients that the predator is deficient in, or extract specific nutrients from a single prey item.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayntz, David -- Raubenheimer, David -- Salomon, Mor -- Toft, Soren -- Simpson, Stephen J -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):111-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. david.mayntz@zoology.oxford.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beetles/*physiology ; Diet ; Dietary Proteins/administration & dosage ; Drosophila ; Feeding Behavior ; Female ; Food ; Grasshoppers ; Lipids/administration & dosage ; Male ; Nutritional Physiological Phenomena ; Predatory Behavior ; Spiders/*physiology
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  • 188
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):419.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239445" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; *Biological Evolution ; Environment ; Europe ; Female ; Male ; Passeriformes/*physiology ; *Reproduction ; Seasons ; *Sexual Behavior, Animal
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  • 189
    Publication Date: 2005-06-11
    Description: Cardiovascular diseases (CVDs), the major cause of morbidity and mortality for both men and women, occur uncommonly in premenopausal women, but their incidence rises sharply after the menopausal transition. Cardiovascular gender differences are apparent long before CVDs appear in men and women, and improved understanding of the biology underlying these differences has the potential to advance the diagnosis and treatment of CVDs in both sexes. This review considers gender differences in the molecular and cellular physiology of the heart and blood vessels in health and disease, highlighting understudied areas that can help resolve the current controversy regarding hormone replacement therapy and improve cardiovascular health in women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mendelsohn, Michael E -- Karas, Richard H -- P50 HL63494-01/HL/NHLBI NIH HHS/ -- R01 HL50569/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1583-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA. mmendelsohn@tufts-nemc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947175" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriosclerosis/etiology/physiopathology ; Blood Vessels/*physiology ; Cardiovascular Diseases/epidemiology/etiology/*physiopathology/prevention & ; control ; *Cardiovascular Physiological Phenomena ; Clinical Trials as Topic ; Estrogen Replacement Therapy ; Female ; Gonadal Steroid Hormones/physiology ; Heart/*physiology ; Humans ; Male ; Myocardium/metabolism ; Receptors, Steroid/physiology ; *Sex Characteristics
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  • 190
    Publication Date: 2005-03-05
    Description: Bacteria that selectively kill males ("male-killers") were first characterized more than 50 years ago in Drosophila and have proved to be common in insects. However, the mechanism by which sex specificity of virulence is achieved has remained unknown. We tested the ability of Spiroplasma poulsonii to kill Drosophila melanogaster males carrying mutations in genes that encode the dosage compensation complex. The bacterium failed to kill males lacking any of the five protein components of the complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veneti, Zoe -- Bentley, Joanna K -- Koana, Takao -- Braig, Henk R -- Hurst, Gregory D D -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1461-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746426" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/genetics/physiology ; Animals ; Chromosomal Proteins, Non-Histone/genetics/physiology ; DNA Helicases/genetics/physiology ; DNA-Binding Proteins ; *Dosage Compensation, Genetic ; Drosophila Proteins/*genetics/physiology ; Drosophila melanogaster/embryology/*genetics/*microbiology/physiology ; Female ; Genes, Insect ; Heterozygote ; Histone Acetyltransferases ; Homozygote ; Male ; Mutation ; Nuclear Proteins/genetics/physiology ; Sex Characteristics ; Spiroplasma/*pathogenicity ; Transcription Factors/genetics/physiology ; Transcription, Genetic ; X Chromosome/metabolism
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  • 191
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):840.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705824" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Basal Metabolism ; Diet ; *Energy Intake ; Energy Metabolism ; Hominidae/anatomy & histology/*physiology ; Humans ; Lung Volume Measurements ; Male ; Models, Anatomic ; Oxygen Consumption ; Respiration
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  • 192
    Publication Date: 2005-11-29
    Description: Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)-mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brebner, Karen -- Wong, Tak Pan -- Liu, Lidong -- Liu, Yitao -- Campsall, Paul -- Gray, Sarah -- Phelps, Lindsay -- Phillips, Anthony G -- Wang, Yu Tian -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1340-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311338" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Addictive ; Behavior, Animal/*drug effects ; Cells, Cultured ; Clathrin/physiology ; Dextroamphetamine/*administration & dosage/pharmacology ; Dynamins/pharmacology ; Endocytosis ; Excitatory Postsynaptic Potentials ; *Long-Term Synaptic Depression/drug effects ; Male ; Membrane Potentials ; Models, Animal ; Motor Activity/*drug effects ; Nucleus Accumbens/drug effects/*physiology ; Patch-Clamp Techniques ; Peptides/pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Recombinant Fusion Proteins/pharmacology ; Stereotyped Behavior/*drug effects ; Synaptic Transmission/drug effects ; Ventral Tegmental Area/drug effects/physiology
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  • 193
    Publication Date: 2005-04-02
    Description: The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation. Nbr1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MuRF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcription factor (SRF). Nuclear translocation of MuRF2 was induced by mechanical inactivity and caused reduction of nuclear SRF and repression of transcription. A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lange, Stephan -- Xiang, Fengqing -- Yakovenko, Andrey -- Vihola, Anna -- Hackman, Peter -- Rostkova, Elena -- Kristensen, Jakob -- Brandmeier, Birgit -- Franzen, Gereon -- Hedberg, Birgitta -- Gunnarsson, Lars Gunnar -- Hughes, Simon M -- Marchand, Sylvie -- Sejersen, Thomas -- Richard, Isabelle -- Edstrom, Lars -- Ehler, Elisabeth -- Udd, Bjarne -- Gautel, Mathias -- G0200496(63216)/Medical Research Council/United Kingdom -- G0300213/Medical Research Council/United Kingdom -- PG/03/049/15364/British Heart Foundation/United Kingdom -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1599-603. Epub 2005 Mar 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Muscle Signalling and Development, Randall Division, King's College London, London SE1 1UL, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802564" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Catalytic Domain ; Cell Line ; Cell Nucleus/metabolism ; Connectin ; *Gene Expression Regulation ; Heat-Shock Proteins/metabolism ; Humans ; Ligands ; Mice ; Mice, Inbred C3H ; Molecular Sequence Data ; Muscle Proteins/*chemistry/genetics/*metabolism ; Muscle, Skeletal/*metabolism ; Muscular Diseases/genetics ; Mutation ; Myocytes, Cardiac/*metabolism ; Protein Binding ; Protein Conformation ; Protein Kinases/*chemistry/genetics/*metabolism ; Protein Structure, Tertiary ; Proteins/metabolism ; Rats ; Respiratory Insufficiency/genetics/metabolism ; Sarcomeres/metabolism ; Serum Response Factor/metabolism ; Signal Transduction ; Two-Hybrid System Techniques ; Ubiquitin-Protein Ligases/metabolism
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  • 194
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1534-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology/physiology ; Cell Culture Techniques ; Cell Differentiation ; Cell Line ; Cell Survival ; *Clinical Trials, Phase I as Topic ; Embryo, Mammalian/*cytology ; Humans ; Mice ; Mice, Nude ; Mutation ; Myelin Sheath/physiology ; Neurons/cytology/physiology ; *Oligodendroglia/cytology/physiology ; Rats ; Spinal Cord Injuries/*therapy ; *Stem Cell Transplantation/adverse effects ; *Stem Cells/cytology/physiology ; Teratoma/etiology ; Time Factors ; United States ; United States Food and Drug Administration
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  • 195
    Publication Date: 2005-10-15
    Description: Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as a candidate gene on chromosome 13q31.1 because of its proximity to a de novo chromosomal inversion in a child with TS. Among 174 unrelated probands, we identified a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189. These variants were absent from 3600 control chromosomes. SLITRK1 mRNA and hsa-miR-189 showed an overlapping expression pattern in brain regions previously implicated in TS. Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, Jesse F -- Kwan, Kenneth Y -- O'Roak, Brian J -- Baek, Danielle Y -- Stillman, Althea A -- Morgan, Thomas M -- Mathews, Carol A -- Pauls, David L -- Rasin, Mladen-Roko -- Gunel, Murat -- Davis, Nicole R -- Ercan-Sencicek, A Gulhan -- Guez, Danielle H -- Spertus, John A -- Leckman, James F -- Dure, Leon S 4th -- Kurlan, Roger -- Singer, Harvey S -- Gilbert, Donald L -- Farhi, Anita -- Louvi, Angeliki -- Lifton, Richard P -- Sestan, Nenad -- State, Matthew W -- K23 RR16118/RR/NCRR NIH HHS/ -- R01 NS054273/NS/NINDS NIH HHS/ -- R01 NS43520/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):317-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16224024" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Adolescent ; Animals ; Attention Deficit Disorder with Hyperactivity/complications/genetics ; Brain/metabolism ; Child ; Child, Preschool ; Chromosome Inversion ; Chromosome Mapping ; *Chromosomes, Human, Pair 13 ; Dna ; DNA Mutational Analysis ; Female ; Frameshift Mutation ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Membrane Proteins/*genetics ; Mice ; *Mutation ; Nerve Tissue Proteins/*genetics ; Pedigree ; Sequence Analysis, DNA ; Tourette Syndrome/complications/*genetics
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  • 196
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1481.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141043" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclooxygenase Inhibitors/*adverse effects ; Drug Industry/*legislation & jurisprudence ; Humans ; Lactones/*adverse effects ; Male ; Middle Aged ; Sulfones/*adverse effects
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  • 197
    Publication Date: 2005-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grant, Robert M -- Buchbinder, Susan -- Cates, Willard Jr -- Clarke, Edith -- Coates, Thomas -- Cohen, Myron S -- Delaney, Martin -- Flores, Guiselly -- Goicochea, Pedro -- Gonsalves, Gregg -- Harrington, Mark -- Lama, Javier R -- MacQueen, Kathleen M -- Moore, John P -- Peterson, Leigh -- Sanchez, Jorge -- Thompson, Melanie -- Wainberg, Mark A -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2170-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, CA, USA. rgrant@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195446" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/adverse effects/*analogs & derivatives/economics/therapeutic use ; Africa ; Anti-HIV Agents/adverse effects/economics/*therapeutic use ; Asia ; Consumer Participation ; *Controlled Clinical Trials as Topic/standards ; Counseling ; Developing Countries ; Drug Costs ; Female ; HIV Infections/*prevention & control ; Health Services Accessibility ; Humans ; Latin America ; Male ; Organophosphonates/adverse effects/economics/*therapeutic use ; Patient Selection ; Tenofovir
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  • 198
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 May 6;308(5723):775.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Databases, Nucleic Acid ; Genetic Variation ; *Genome ; *Genome, Human ; Genomics ; Human Genome Project ; Humans ; Mice ; *Private Sector ; *Public Sector ; Publishing ; Rats
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  • 199
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1729.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961641" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*cytology/*growth & development ; Cell Differentiation ; Cells, Cultured ; *Gene Expression Regulation ; Humans ; *Long Interspersed Nucleotide Elements ; Mice ; Mice, Transgenic ; Neurons/*cytology/physiology ; Rats ; Stem Cells/*cytology/physiology
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  • 200
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: Sexual selection is a potent evolutionary force. However, very few models have considered the evolution of female preferences for traits expressed in both sexes. Here we explore how female preferences coevolve with sexually antagonistic traits, which involve alleles that are beneficial to one sex but harmful to the other. We show that with a sexually antagonistic trait on the X chromosome (males XY, females XX), females evolve to prefer mates carrying alleles beneficial to daughters. In contrast, with a Z-linked trait (males ZZ, females ZW), females more often evolve mating preferences for mates carrying alleles beneficial to sons (that is, flashy displays).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Albert, Arianne Y K -- Otto, Sarah P -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):119-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. albert@zoology.ubc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210543" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; *Biological Evolution ; Female ; Genetic Linkage ; Linkage Disequilibrium ; Male ; Mathematics ; Models, Genetic ; Polymorphism, Genetic ; *Reproduction ; *Selection, Genetic ; Sex Chromosomes/genetics ; *Sex Determination Processes ; *Sexual Behavior, Animal ; X Chromosome/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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