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  • 1
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    Circadian proteome in mouse liver [Biochemistry] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-01-08
    Description: Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known about the accumulation patterns of proteins. Here, we quantified temporal profiles in the murine hepatic...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Rapid rewiring of the VTA by palatable food [Neuroscience] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-03-02
    Description: In an environment with easy access to highly palatable and energy-dense food, food-related cues drive food-seeking regardless of satiety, an effect that can lead to obesity. The ventral tegmental area (VTA) and its mesolimbic projections are critical structures involved in the learning of environmental cues used to predict motivationally relevant...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Mammalian genes are transcribed with widely different bursting kinetics (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-19
    Description: In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods called transcriptional bursts, interspersed by silent intervals. We describe how such bursts generate gene-specific temporal patterns of messenger RNA (mRNA) synthesis in mammalian cells. To monitor transcription at high temporal resolution, we established various gene trap cell lines and transgenic cell lines expressing a short-lived luciferase protein from an unstable mRNA, and recorded bioluminescence in real time in single cells. Mathematical modeling identified gene-specific on- and off-switching rates in transcriptional activity and mean numbers of mRNAs produced during the bursts. Transcriptional kinetics were markedly altered by cis-regulatory DNA elements. Our analysis demonstrated that bursting kinetics are highly gene-specific, reflecting refractory periods during which genes stay inactive for a certain time before switching on again.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suter, David M -- Molina, Nacho -- Gatfield, David -- Schneider, Kim -- Schibler, Ueli -- Naef, Felix -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):472-4. doi: 10.1126/science.1198817. Epub 2011 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21415320" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Cells, Cultured ; Chromatin/physiology ; Circadian Rhythm/genetics ; Down-Regulation ; *Gene Expression ; Histones/metabolism ; Kinetics ; Luminescent Measurements ; Mice ; Models, Genetic ; NIH 3T3 Cells ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA, Messenger/genetics/metabolism ; Stochastic Processes ; *Transcription, Genetic ; Transcriptional Activation ; Transgenes ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Freedom and rules: the acquisition and reprogramming of a bird's learned song (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-14
    Description: Canary song is hierarchically structured: Short stereotyped syllables are repeated to form phrases, which in turn are arranged to form songs. This structure occurs even in the songs of young isolates, which suggests that innate rules govern canary song development. However, juveniles that had never heard normal song imitated abnormal synthetic songs with great accuracy, even when the tutor songs lacked phrasing. As the birds matured, imitated songs were reprogrammed to form typical canary phrasing. Thus, imitation and innate song constraints are separate processes that can be segregated in time: freedom in youth, rules in adulthood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gardner, Timothy J -- Naef, Felix -- Nottebohm, Fernando -- MH18343/MH/NIMH NIH HHS/ -- MH63132/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 May 13;308(5724):1046-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Animal Behavior, Rockefeller University, New York, NY 10021, USA. tgardner@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890887" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Canaries/growth & development/*physiology ; Female ; *Imitative Behavior ; *Learning ; Male ; Memory ; Sexual Maturation ; Testosterone/pharmacology ; *Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-21
    Description: Embryogenesis depends on self-regulatory interactions between spatially separated signaling centers, but few of these are well understood. Limb development is regulated by epithelial-mesenchymal (e-m) feedback loops between sonic hedgehog (SHH) and fibroblast growth factor (FGF) signaling involving the bone morphogenetic protein (BMP) antagonist Gremlin1 (GREM1). By combining mouse molecular genetics with mathematical modeling, we showed that BMP4 first initiates and SHH then propagates e-m feedback signaling through differential transcriptional regulation of Grem1 to control digit specification. This switch occurs by linking a fast BMP4/GREM1 module to the slower SHH/GREM1/FGF e-m feedback loop. This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benazet, Jean-Denis -- Bischofberger, Mirko -- Tiecke, Eva -- Goncalves, Alexandre -- Martin, James F -- Zuniga, Aimee -- Naef, Felix -- Zeller, Rolf -- 2R01DE12324-12/DE/NIDCR NIH HHS/ -- R01DE16329/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 20;323(5917):1050-3. doi: 10.1126/science.1168755.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19229034" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Patterning ; Bone Morphogenetic Protein 4/genetics/metabolism ; Epithelium/embryology/metabolism ; *Feedback, Physiological ; Fibroblast Growth Factors/genetics/metabolism ; Forelimb/*embryology ; Hedgehog Proteins/genetics/metabolism ; Intercellular Signaling Peptides and Proteins/genetics/metabolism ; Limb Buds/embryology/metabolism ; Mesoderm/metabolism ; Mice ; Models, Biological ; *Signal Transduction ; Toes/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-28
    Description: In mammalian tissues, circadian gene expression can be driven by local oscillators or systemic signals controlled by the master pacemaker in the suprachiasmatic nucleus. We show that simulated body temperature cycles, but not peripheral oscillators, controlled the rhythmic expression of cold-inducible RNA-binding protein (CIRP) in cultured fibroblasts. In turn, loss-of-function experiments indicated that CIRP was required for high-amplitude circadian gene expression. The transcriptome-wide identification of CIRP-bound RNAs by a biotin-streptavidin-based cross-linking and immunoprecipitation (CLIP) procedure revealed several transcripts encoding circadian oscillator proteins, including CLOCK. Moreover, CLOCK accumulation was strongly reduced in CIRP-depleted fibroblasts. Because ectopic expression of CLOCK improved circadian gene expression in these cells, we surmise that CIRP confers robustness to circadian oscillators through regulation of CLOCK expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morf, Jorg -- Rey, Guillaume -- Schneider, Kim -- Stratmann, Markus -- Fujita, Jun -- Naef, Felix -- Schibler, Ueli -- New York, N.Y. -- Science. 2012 Oct 19;338(6105):379-83. doi: 10.1126/science.1217726. Epub 2012 Aug 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, University of Geneva, and National Centre of Competence in Research, Frontiers in Genetics, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22923437" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotin ; CLOCK Proteins/*genetics/metabolism ; Chromatin Immunoprecipitation ; Circadian Rhythm/*genetics ; Cold Temperature ; Fibroblasts/metabolism ; Gene Expression Profiling ; *Gene Expression Regulation ; Mice ; NIH 3T3 Cells ; RNA, Messenger/genetics/metabolism ; RNA-Binding Proteins/genetics/*metabolism ; Streptavidin ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Stereospecific syntheses of uleine and epiuleine (1971)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 93 (1971), S. 2492-2501 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00739a022
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Grignard and hydride addition to a ketene intermediate: a novel access to α-damascone and α-cyclocitral
    Amsterdam : Elsevier
    Tetrahedron 42 (1986), S. 3245-3250 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)87388-9
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  • 9
    Electronic Resource
    Electronic Resource
    Structure and absolute configuration of (–)-sclareol-8-acetate (1988)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 44 (1988), S. 715-717 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270187012538
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of exposure to a simulated altitude of 3,500 m on calves and oxen (1978)
    Springer
    International journal of biometeorology 22 (1978), S. 135-146 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Nine calves and nine oxen were divided into 6 groups and exposed in a climatised low pressure chamber to the following conditions: 2 weeks at 400 m and 4 weeks at 3,500 m. High altitude produced the following changes: increases in heart rate and pulmonary artery pressure, both these changes being larger in the calves than in the oxen. During 4 weeks continuous exposure to 3,500 m, heart rate declined, whereas pulmonary arterial pressure rose. There were increments in respiratory rate, blood-pH, leucocyte number, rectal temperature, blood lactate and blood pyruvate, but no changes in the lactate/pyruvate ratio. Increases in erythrocyte number, haemoglobin, haematocrit, blood specific gravity and blood viscosity were more pronounced in the oxen than in the calves. Feed intake in all animals tended to be depressed in the first half of the high altitude periode. Water intake showed a fall during the first day at 3,500 m, but recovered thereafter. It is concluded that in response to high altitude the calves activated preferentially the circulatory, the oxen the erythropoetic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01552894
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