Publication Date:
1993-09-17
Description:
The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes without Bcl-2 differentiated into phenotypically mature cells. However, in vitro, the mature T cells that lacked Bcl-2 had shorter life-spans and increased sensitivity to glucocorticoids and gamma-irradiation. In contrast, stimulation of CD3 inhibited the death of these cells. T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakayama, K -- Negishi, I -- Kuida, K -- Shinkai, Y -- Louie, M C -- Fields, L E -- Lucas, P J -- Stewart, V -- Alt, F W -- AI 15322/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Sep 17;261(5128):1584-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8372353" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD3/immunology
;
Apoptosis
;
B-Lymphocytes/cytology/*immunology
;
Base Sequence
;
Bone Marrow/immunology
;
Bone Marrow Cells
;
Cell Line
;
Chimera
;
Homozygote
;
Humans
;
Lymphoid Tissue/cytology/immunology
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Proto-Oncogene Proteins/genetics/*physiology
;
Proto-Oncogene Proteins c-bcl-2
;
Proto-Oncogenes
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocytes/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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