Publication Date:
2014-08-30
Description:
The influential notion that the hippocampus supports associative memory by interacting with functionally distinct and distributed brain regions has not been directly tested in humans. We therefore used targeted noninvasive electromagnetic stimulation to modulate human cortical-hippocampal networks and tested effects of this manipulation on memory. Multiple-session stimulation increased functional connectivity among distributed cortical-hippocampal network regions and concomitantly improved associative memory performance. These alterations involved localized long-term plasticity because increases were highly selective to the targeted brain regions, and enhancements of connectivity and associative memory persisted for ~24 hours after stimulation. Targeted cortical-hippocampal networks can thus be enhanced noninvasively, demonstrating their role in associative memory.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307924/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307924/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Jane X -- Rogers, Lynn M -- Gross, Evan Z -- Ryals, Anthony J -- Dokucu, Mehmet E -- Brandstatt, Kelly L -- Hermiller, Molly S -- Voss, Joel L -- F32 NS083340/NS/NINDS NIH HHS/ -- F32-NS083340/NS/NINDS NIH HHS/ -- P50 MH094263/MH/NIMH NIH HHS/ -- P50-MH094263/MH/NIMH NIH HHS/ -- T32 NS047987/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1054-7. doi: 10.1126/science.1252900.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ; The Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL, USA. ; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ; Department of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. joel-voss@northwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170153" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
*Association
;
Female
;
Hippocampus/*physiology
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Memory/*physiology
;
Nerve Net/physiology
;
Parietal Lobe/*physiology
;
*Transcranial Magnetic Stimulation
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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