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  • 1
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    Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-08-26
    Description: In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmert, M R -- Golde, T E -- Cohen, M L -- Kovacs, D M -- Tanzi, R E -- Gusella, J F -- Usiak, M F -- Younkin, L H -- Younkin, S G -- 5T32GM07250/GM/NIGMS NIH HHS/ -- AG06656/AG/NIA NIH HHS/ -- MH43444/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1988 Aug 26;241(4869):1080-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neuropathology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2457949" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*genetics ; Amyloid/*genetics ; Bacteriophage lambda/genetics ; Brain/metabolism ; Cerebral Cortex/metabolism ; *Gene Expression Regulation ; Humans ; Locus Coeruleus/metabolism ; Neurons/metabolism ; Nucleic Acid Hybridization ; Operator Regions, Genetic ; Plasmids ; Protein Precursors/*genetics ; RNA/genetics ; RNA, Complementary ; RNA, Messenger/*genetics/metabolism ; Repressor Proteins/metabolism ; Transcription, Genetic ; Trypsin Inhibitors/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Prediction of new low compressibility solids (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-08-25
    Description: An empirical model and an ab initio calculation of the bulk moduli for covalent solids are used to suggest possible new hard materials. The empirical model indicates that hypothetical covalent solids formed between carbon and nitrogen are good candidates for extreme hardness. A prototype system is chosen and a first principles pseudopotential total energy calculation on the system is performed. The results are consistent with the empirical model and show that materials like the prototype can have bulk moduli comparable to or greater than diamond. It may be possible to synthesize such materials in the laboratory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, A Y -- Cohen, M L -- New York, N.Y. -- Science. 1989 Aug 25;245(4920):841-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773359" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Small phonon contribution to the photoemission kink in the copper oxide superconductors (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-04-25
    Description: Despite over two decades of intense research efforts, the origin of high-temperature superconductivity in the copper oxides remains elusive. Angle-resolved photoemission spectroscopy experiments have revealed a kink in the dispersion relations (energy versus wavevector) of electronic states in the copper oxides at binding energies of 50-80 meV, raising the hope that this anomaly could be a key to understanding high-temperature superconductivity. The kink is often interpreted in terms of interactions between the electrons and a bosonic field. Although there is no consensus on the nature of the bosons (or even whether a boson model is appropriate), both phonons and spin fluctuations have been proposed as possible candidates. Here we report first-principles calculations of the role of phonons and the electron-phonon interaction in the photoemission spectra of La(2 - x)Sr(x)CuO4. Our calculations within the standard formalism demonstrate that the phonon-induced renormalization of the electron energies and the Fermi velocity is almost one order of magnitude smaller than the effect observed in photoemission experiments. Therefore, our result rules out electron-phonon interaction in bulk La(2 - x)Sr(x)CuO4 as the exclusive origin of the measured kink. Our conclusions are consistent with those reached independently in a recent study of the related compound YBa2Cu3O7.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giustino, Feliciano -- Cohen, Marvin L -- Louie, Steven G -- England -- Nature. 2008 Apr 24;452(7190):975-8. doi: 10.1038/nature06874.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California at Berkeley, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18432241" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Tuning High-Tc Superconductors via Multistage Intercalation (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-06
    Description: Multistage intercalation has been used to tune the interaction between adjacent blocks of CuO(2) sheets in the bigh-T(c) (high superconducting transition temperature) superconductor Bi(2)Sr(2)CaCu(2)Ox. As revealed by atomic-resolution transmission electron microscopy images, foreign iodine atoms are intercalated into every nth BiO bilayer of the host crystal, resulting in structures of stoichiometry IBi2nSr2nCanCu2nOx with stage index n up to 4. An expansion of 3.6 angstroms for each intercalated BiO bilayer decouples the CuO(2) sheets in adjacent blocks. A comparison of the superconducting transition temperatures of the pristine host material and intercalated compounds of different stages suggests that the coupling between each pair of adjacent blocks contributes approximately 5 K to T(c) in Bi(2)Sr(2)CaCu(2)Ox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xiang, X D -- Vareka, W A -- Zettl, A -- Corkill, J L -- Barbee, T W 3rd -- Cohen, M L -- Kijima, N -- Gronsky, R -- New York, N.Y. -- Science. 1991 Dec 6;254(5037):1487-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773298" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Synthesis and Electronic Transport of Single Crystal K3C60 (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-05-22
    Description: Sizable single crystals of C(6O) have been synthesized and doped with potassium. Above the superconducting transition temperature T(c), the electrical resistivity p(T) displays a classic metal-like temperature dependence. The transition to the superconducting state at T(c) = 19.8 K is extremely sharp, with a transition width DeltaT 〈 200 mK. In contrast to transport behavior of doped polycrystalline and granular thin films, no anomalous fluctuations are observed near T(c) in single crystal specimens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xiang, X D -- Hou, J G -- Briceno, G -- Vareka, W A -- Mostovoy, R -- Zettl, A -- Crespi, V H -- Cohen, M L -- New York, N.Y. -- Science. 1992 May 22;256(5060):1190-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17795215" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Ultrahigh-pressure melting of lead: a multidisciplinary study (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-04-27
    Description: Measurements of the melting temperature of lead, carried out to pressures of 1 megabar (10(11) pascal) and temperatures near 4000 kelvin by means of a laser-heated diamond cell, are in excellent agreement with the results of previous shock-wave experiments. The data are analyzed by means of first principles quantum mechanical calculations, and the agreement documents the reliability of current experimental and theoretical techniques for studies of melting at ultrahigh pressures. These studies have potentially wide-ranging applications, from planetary science to condensed matter physics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Godwal, B K -- Meade, C -- Jeanloz, R -- Garcia, A -- Liu, A Y -- Cohen, M L -- New York, N.Y. -- Science. 1990 Apr 27;248(4954):462-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17815595" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Graphene at the edge: stability and dynamics (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-28
    Description: Although the physics of materials at surfaces and edges has been extensively studied, the movement of individual atoms at an isolated edge has not been directly observed in real time. With a transmission electron aberration-corrected microscope capable of simultaneous atomic spatial resolution and 1-second temporal resolution, we produced movies of the dynamics of carbon atoms at the edge of a hole in a suspended, single atomic layer of graphene. The rearrangement of bonds and beam-induced ejection of carbon atoms are recorded as the hole grows. We investigated the mechanism of edge reconstruction and demonstrated the stability of the "zigzag" edge configuration. This study of an ideal low-dimensional interface, a hole in graphene, exhibits the complex behavior of atoms at a boundary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Girit, Caglar O -- Meyer, Jannik C -- Erni, Rolf -- Rossell, Marta D -- Kisielowski, C -- Yang, Li -- Park, Cheol-Hwan -- Crommie, M F -- Cohen, Marvin L -- Louie, Steven G -- Zettl, A -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1705-8. doi: 10.1126/science.1166999.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325110" target="_blank"〉PubMed〈/a〉
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  • 8
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    Public health and biosecurity. Adaptations of avian flu virus are a cause for concern (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berns, Kenneth I -- Casadevall, Arturo -- Cohen, Murray L -- Ehrlich, Susan A -- Enquist, Lynn W -- Fitch, J Patrick -- Franz, David R -- Fraser-Liggett, Claire M -- Grant, Christine M -- Imperiale, Michael J -- Kanabrocki, Joseph -- Keim, Paul S -- Lemon, Stanley M -- Levy, Stuart B -- Lumpkin, John R -- Miller, Jeffery F -- Murch, Randall -- Nance, Mark E -- Osterholm, Michael T -- Relman, David A -- Roth, James A -- Vidaver, Anne K -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):660-1. doi: 10.1126/science.1217994. Epub 2012 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Institute, University of Florida, Gainesville, FL 32611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22294736" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Advisory Committees ; Animals ; Biological Warfare Agents ; Containment of Biohazards ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza, Human/epidemiology/transmission/*virology ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; *Public Health ; *Publishing ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Band structure and Fermi surface of electron-doped C60 monolayers (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-04-12
    Description: C60 fullerides are challenging systems because both the electron-phonon and electron-electron interactions are large on the energy scale of the expected narrow band width. We report angle-resolved photoemission data on the band dispersion for an alkali-doped C60 monolayer and a detailed comparison with theory. Compared to the maximum bare theoretical band width of 170 meV, the observed 100-meV dispersion is within the range of renormalization by electron-phonon coupling. This dispersion is only a fraction of the integrated peak width, revealing the importance of many-body effects. Additionally, measurements on the Fermi surface indicate the robustness of the Luttinger theorem even for materials with strong interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, W L -- Brouet, V -- Zhou, X J -- Choi, Hyoung J -- Louie, Steven G -- Cohen, Marvin L -- Kellar, S A -- Bogdanov, P V -- Lanzara, A -- Goldoni, A -- Parmigiani, F -- Hussain, Z -- Shen, Z-X -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):303-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Advanced Light Source (ALS), Materials Science Division, Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690192" target="_blank"〉PubMed〈/a〉
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  • 10
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    Predicting useful materials (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M L -- New York, N.Y. -- Science. 1993 Jul 16;261(5119):307-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17836841" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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