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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-11-14
    Description: Genetic testing for cancer susceptibility is already part of the clinical management of families with some of the well-defined (but uncommon) inherited cancer syndromes. In cases where the risks associated with a predisposing mutation are less certain, or where there is no clearly effective intervention to offer those with a positive result, its use is more controversial. Careful evaluation of costs and benefits, and of the efficacy of interventions in those found to be at risk, is essential and is only just beginning. An immediate challenge is to ensure that both health professionals and the public understand clearly the issues involved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ponder, B -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1050-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Box 238, Level 3 Lab Block, Hills Road, Cambridge CB2 2QQ, UK. bajp@mole.bio.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353178" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Cost-Benefit Analysis ; Female ; Genetic Counseling ; Genetic Predisposition to Disease ; Genetic Services ; *Genetic Testing ; Genetic Variation ; Humans ; Insurance, Health ; Insurance, Life ; Male ; Mutation ; Neoplasms/*diagnosis/*genetics ; Resource Allocation ; Risk Assessment ; Risk Factors ; Uncertainty
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1990.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221504" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Nucleus/ultrastructure ; Chromosomes, Human/ultrastructure ; Coloring Agents ; *Cytological Techniques ; Female ; Humans ; Image Processing, Computer-Assisted ; Microscopy, Interference/*methods ; Spectrum Analysis ; Uterine Cervical Dysplasia/pathology
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 30;276(5317):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190674" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Zoo/genetics ; Cloning, Molecular ; *Conservation of Natural Resources ; Costs and Cost Analysis ; Cryopreservation ; Female ; Fibroblasts/cytology ; *Genetic Engineering/economics ; Genetic Variation ; Reproduction, Asexual ; Sheep ; Species Specificity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tiedemann, R -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1550-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411772" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Elephants/*anatomy & histology/*physiology ; Female ; Incisor/anatomy & histology ; India ; Male ; Models, Biological ; Models, Statistical ; *Sexual Behavior, Animal ; Sri Lanka
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  • 5
    Publication Date: 1997-07-04
    Description: Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maisonpierre, P C -- Suri, C -- Jones, P F -- Bartunkova, S -- Wiegand, S J -- Radziejewski, C -- Compton, D -- McClain, J -- Aldrich, T H -- Papadopoulos, N -- Daly, T J -- Davis, S -- Sato, T N -- Yancopoulos, G D -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):55-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204896" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Angiopoietin-1 ; Angiopoietin-2 ; Animals ; Blood Vessels/embryology/*metabolism ; Cells, Cultured ; Cloning, Molecular ; Embryo, Mammalian/metabolism ; Endothelial Growth Factors/genetics/metabolism ; Endothelium, Vascular/*cytology/metabolism ; Female ; Humans ; Ligands ; Lymphokines/genetics/metabolism ; Membrane Glycoproteins/antagonists & inhibitors/metabolism ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; *Neovascularization, Physiologic ; Phosphorylation ; Proteins/chemistry/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism ; Receptor, TIE-2 ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122702" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Breast Neoplasms/*prevention & control/radiography ; Consensus Development Conferences, NIH as Topic ; Female ; Humans ; *Mammography ; *Mass Screening ; Middle Aged ; *National Institutes of Health (U.S.) ; Randomized Controlled Trials as Topic ; Risk Factors ; United States
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  • 7
    Publication Date: 1997-08-15
    Description: Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in pain affect, hypnotic suggestions were used to alter selectively the unpleasantness of noxious stimuli, without changing the perceived intensity. Positron emission tomography revealed significant changes in pain-evoked activity within anterior cingulate cortex, consistent with the encoding of perceived unpleasantness, whereas primary somatosensory cortex activation was unaltered. These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rainville, P -- Duncan, G H -- Price, D D -- Carrier, B -- Bushnell, M C -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):968-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉D-epartement de Psychologie and Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252330" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affect/*physiology ; *Brain Mapping ; Female ; Frontal Lobe/blood supply/*physiology/radionuclide imaging ; Gyrus Cinguli/blood supply/*physiology/radionuclide imaging ; Humans ; Hypnosis ; Male ; Middle Aged ; Pain/*physiopathology/*psychology ; Pain Measurement ; Regional Blood Flow ; Regression Analysis ; Somatosensory Cortex/blood supply/*physiology/radionuclide imaging ; Thermosensing ; Tomography, Emission-Computed
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 16;276(5315):1022.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9173534" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Anti-HIV Agents/administration & dosage/*therapeutic use ; *Bioethics ; Caribbean Region ; *Control Groups ; Controlled Clinical Trials as Topic/*standards ; Female ; HIV Infections/drug therapy/prevention & control/*transmission ; Humans ; Infectious Disease Transmission, Vertical/*prevention & control ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; *Pregnant Women ; Thailand ; Therapeutic Human Experimentation ; Withholding Treatment ; Zidovudine/administration & dosage/*therapeutic use
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-09-26
    Description: A selection strategy was devised to identify bacterial genes preferentially expressed when a bacterium associates with its host cell. Fourteen Salmonella typhimurium genes, which were under the control of at least four independent regulatory circuits, were identified to be selectively induced in host macrophages. Four genes encode virulence factors, including a component of a type III secretory apparatus. This selection methodology should be generally applicable to the identification of genes from pathogenic organisms that are induced upon association with host cells or tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valdivia, R H -- Falkow, S -- AI26195/AI/NIAID NIH HHS/ -- DK38707/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):2007-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. valdivia@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9302299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/genetics ; Cell Line ; Cloning, Molecular ; Female ; Flow Cytometry ; Fluorescence ; *Gene Expression Regulation, Bacterial ; Green Fluorescent Proteins ; HeLa Cells ; Humans ; Luminescent Proteins/genetics ; Macrophages/*microbiology ; Mice ; Mice, Inbred BALB C ; Microscopy, Fluorescence ; Molecular Sequence Data ; Open Reading Frames ; Promoter Regions, Genetic ; Recombinant Fusion Proteins ; Salmonella Infections, Animal/microbiology ; Salmonella typhimurium/*genetics/isolation & purification/*pathogenicity ; Spleen/microbiology ; Transcription Factors/genetics ; Virulence/genetics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-02-14
    Description: Once a specific number of cells have been produced in the early Xenopus laevis embryo, replicon size during the S phase of the cell cycle increases. Here, it is reported that similar increase in replicon size occurred when the concentration of nuclei in replication-competent Xenopus egg extracts exceeded a critical threshold. In this system, the origin recognition complex (ORC) did not become stoichiometrically limiting for initiation, and similar amounts of this complex bound to chromatin regardless of replicon size. These data suggest that in early development, an unidentified factor controls how many preformed ORC-DNA complexes initiate DNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walter, J -- Newport, J W -- 1F32FM17980-01/PHS HHS/ -- R01FM44656/PHS HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):993-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle Proteins/metabolism ; Chromatin/metabolism ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins/pharmacology ; Cytarabine/pharmacology ; DNA/*metabolism ; *DNA Replication ; DNA-Binding Proteins/*metabolism ; Enzyme Inhibitors/pharmacology ; Female ; Origin Recognition Complex ; Ovum/*metabolism ; Replication Origin ; *Replicon ; S Phase ; Xenopus laevis
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  • 11
    Publication Date: 1997-01-17
    Description: Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human apolipoprotein C-III (APOC3) transgene with mice deficient in the LDL receptor. A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis. This mouse model may provide clues to the origin of human FCHL.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masucci-Magoulas, L -- Goldberg, I J -- Bisgaier, C L -- Serajuddin, H -- Francone, O L -- Breslow, J L -- Tall, A R -- HL 21006/HL/NHLBI NIH HHS/ -- HL 54591/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Columbia University, 630 West 168 Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8994037" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apolipoprotein C-III ; Apolipoproteins B/blood ; Apolipoproteins C/*genetics ; Apolipoproteins E/blood ; Arteriosclerosis/etiology ; Carrier Proteins/genetics ; Cholesterol/blood ; Cholesterol Ester Transfer Proteins ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cholesterol, VLDL/blood ; Diet ; *Disease Models, Animal ; Disease Susceptibility ; Female ; *Glycoproteins ; Humans ; *Hyperlipidemia, Familial Combined/blood/genetics ; Hyperlipoproteinemia Type IV/genetics ; Lipoproteins/blood ; Lipoproteins, VLDL/blood ; Male ; Mice ; Mice, Inbred C57BL ; *Mice, Transgenic ; Receptors, LDL/*genetics/metabolism ; Transgenes ; Triglycerides/blood
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-09-05
    Description: Two human tumor cell lines that are deficient in the mismatch repair protein hMSH2 show little or no increase in mutation rate relative to that of a mismatch repair-proficient cell line when the cells are maintained in culture conditions allowing rapid growth. However, mutations accumulate at a high rate in these cells when they are maintained at high density. Thus the mutator phenotype of some mismatch repair-deficient cell lines is conditional and strongly depends on growth conditions. These observations have implications for tumor development because they suggest that mutations may accumulate in tumor cells when growth is limited.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richards, B -- Zhang, H -- Phear, G -- Meuth, M -- R01-CA-62244/CA/NCI NIH HHS/ -- T32-CA-09602/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1523-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9278518" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Count ; *Cell Division ; *DNA Repair ; DNA Replication ; *DNA-Binding Proteins ; Drug Resistance, Neoplasm ; Female ; Frameshift Mutation ; Humans ; Hypoxanthine Phosphoribosyltransferase/genetics ; Microsatellite Repeats ; MutS Homolog 2 Protein ; *Mutation ; Neoplasms/*genetics/pathology ; Ouabain/pharmacology ; Ovarian Neoplasms/genetics/pathology ; Phenotype ; Proto-Oncogene Proteins/genetics/*physiology ; Tumor Cells, Cultured ; Uterine Neoplasms/genetics/pathology
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 Apr 25;276(5312):519.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148403" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/transmission ; Anti-HIV Agents/*therapeutic use ; *Controlled Clinical Trials as Topic/standards ; *Developing Countries ; *Ethics, Medical ; Female ; Humans ; Infant ; Infant, Newborn ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Zidovudine/therapeutic use
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Apr 25;276(5312):525-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148408" target="_blank"〉PubMed〈/a〉
    Keywords: California ; *Drug Industry ; Drugs, Generic/*pharmacokinetics ; Female ; Humans ; *Publishing ; Randomized Controlled Trials as Topic ; Therapeutic Equivalency ; Thyroxine/*pharmacokinetics ; Universities
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, M -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1743.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122678" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Butterflies/parasitology ; Female ; Male ; Moths/parasitology ; Ovum/parasitology ; *Parthenogenesis ; Rickettsiaceae/*physiology ; Wasps/microbiology/*physiology
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1997 May 30;276(5317):1324-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190672" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Centers for Disease Control and Prevention (U.S.) ; Exercise/*physiology/psychology ; Female ; Guidelines as Topic ; Heart Diseases/epidemiology/*prevention & control ; Humans ; Male ; Middle Aged ; Risk Factors ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1997 Aug 1;277(5326):641.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9254430" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Infant ; *Language Development ; Mothers ; *Phonetics ; Speech Acoustics ; *Speech Perception
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-10-23
    Description: Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morrison, J H -- Hof, P R -- AG05138/AG/NIA NIH HHS/ -- AG06647/AG/NIA NIH HHS/ -- MHDA52145/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 17;278(5337):412-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurobiology of Aging Laboratories, the Fishberg Research Center for Neurobiology, and the Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA. morrison@cortex.neuro.mssm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9334292" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alzheimer Disease/pathology ; Animals ; Cell Death ; Cell Survival ; Entorhinal Cortex/pathology ; Estrogens/physiology ; Female ; Hippocampus/cytology/pathology/*physiology ; Humans ; Male ; Memory ; Neocortex/cytology/pathology/*physiology ; *Nerve Degeneration ; Neurofibrillary Tangles/pathology ; Neurofilament Proteins/metabolism ; Neurons/cytology/pathology/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bagla, P -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1972.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221498" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Commerce ; Elephants/*anatomy & histology/genetics/*parasitology ; Female ; Helminthiasis, Animal/*immunology ; Immunity, Innate ; Incisor/anatomy & histology ; Male ; Parasite Egg Count/veterinary ; Sexual Behavior, Animal
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baskin, Y -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1786.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9206836" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/microbiology ; Animals ; *Bison ; *Brucella abortus ; Brucellosis/*epidemiology/transmission ; Brucellosis, Bovine/*transmission ; Cattle ; Female ; Montana/epidemiology ; Pregnancy ; Risk Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 1997 May 2;276(5313):675-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157544" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*drug therapy ; Animals ; Antioxidants/pharmacology ; Brain/cytology/metabolism ; Choline O-Acetyltransferase/metabolism ; Cognition/drug effects/*physiology ; Controlled Clinical Trials as Topic ; Estrogens/pharmacology/*physiology/therapeutic use ; Female ; Humans ; Male ; Memory/drug effects/*physiology ; Nerve Growth Factors/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wrangham, R W -- New York, N.Y. -- Science. 1997 Aug 8;277(5327):774-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, Harvard University, Cambridge, MA 02138, USA. wrangham@fas.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9273699" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Male ; Pan troglodytes/*psychology ; *Reproduction ; *Sexual Behavior, Animal ; *Social Dominance
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1997 Apr 25;276(5312):533.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148412" target="_blank"〉PubMed〈/a〉
    Keywords: Adhesins, Bacterial/*immunology ; *Adhesins, Escherichia coli ; Animals ; Antibodies, Bacterial/biosynthesis ; *Bacterial Vaccines/administration & dosage/immunology ; Clinical Trials as Topic ; Escherichia coli/*immunology ; Escherichia coli Infections/*prevention & control ; Female ; *Fimbriae Proteins ; Humans ; Immunoglobulin G/biosynthesis ; Mice ; Urinary Tract Infections/immunology/*prevention & control ; Vaccination ; Vaccines, Inactivated/administration & dosage/immunology ; *Vaccines, Synthetic/administration & dosage/immunology
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  • 24
    Publication Date: 1997-04-18
    Description: The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae, normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zheng, L -- Cornel, A J -- Wang, R -- Erfle, H -- Voss, H -- Ansorge, W -- Kafatos, F C -- Collins, F H -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):425-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Disease Control and Prevention, 4770 Buford Hi.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9103203" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*genetics/immunology/*parasitology ; Chromosome Mapping ; Crosses, Genetic ; Female ; *Genes, Insect ; Genotype ; Insect Vectors/*genetics/immunology/*parasitology ; Lod Score ; Male ; Melanins/physiology ; Microsatellite Repeats ; Phenotype ; Plasmodium cynomolgi/*immunology
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  • 25
    Publication Date: 1997-10-06
    Description: Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With the use of a conditional gene targeting system, a mouse model of FAP was created that circumvents the embryonic lethality of Apc deficiency and directs Apc inactivation specifically to the colorectal epithelium. loxP sites were inserted into the introns around Apc exon 14, and the resultant mutant allele (Apc580S) was introduced into the mouse germline. Mice homozygous for Apc580S were normal; however, upon infection of the colorectal region with an adenovirus encoding the Cre recombinase, the mice developed adenomas within 4 weeks. The adenomas showed deletion of Apc exon 14, indicating that the loss of Apc function was caused by Cre-loxP-mediated recombination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shibata, H -- Toyama, K -- Shioya, H -- Ito, M -- Hirota, M -- Hasegawa, S -- Matsumoto, H -- Takano, H -- Akiyama, T -- Toyoshima, K -- Kanamaru, R -- Kanegae, Y -- Saito, I -- Nakamura, Y -- Shiba, K -- Noda, T -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):120-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Cancer Institute, Toshima-ku, Tokyo 170, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311916" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli/*genetics ; Adenomatous Polyposis Coli Protein ; Adenoviridae/genetics ; Animals ; Colon/metabolism ; Cytoskeletal Proteins/biosynthesis ; Disease Models, Animal ; Exons ; Female ; Frameshift Mutation ; Gene Deletion ; *Gene Targeting ; *Genes, APC ; Genetic Vectors ; Germ-Line Mutation ; Homozygote ; Integrases/genetics/metabolism ; Introns ; Male ; Mice ; Mice, Inbred C57BL ; Recombination, Genetic ; *Viral Proteins
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  • 26
    Publication Date: 1997-10-06
    Description: Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ollmann, M M -- Wilson, B D -- Yang, Y K -- Kerns, J A -- Chen, Y -- Gantz, I -- Barsh, G S -- EY07106/EY/NEI NIH HHS/ -- GM07365/GM/NIGMS NIH HHS/ -- P30DK-34933/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):135-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311920" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/metabolism ; Amino Acid Sequence ; Animals ; Female ; Humans ; Hypothalamus/metabolism ; Male ; Melanocyte-Stimulating Hormones/antagonists & inhibitors/pharmacology ; Melanophores/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Obese ; Mice, Transgenic ; Molecular Sequence Data ; Obesity/etiology ; Organophosphorus Compounds/pharmacology ; Proteins/chemistry/genetics/pharmacology/*physiology ; RNA/genetics/metabolism ; Receptor, Melanocortin, Type 3 ; Receptor, Melanocortin, Type 4 ; Receptors, Corticotropin/*antagonists & inhibitors/metabolism ; Receptors, Peptide/*antagonists & inhibitors/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction ; Xenopus
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gavrilov, L A -- Gavrilova, N S -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):17-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9229762" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; *Longevity ; Male ; *Nuclear Family ; *Paternal Age
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  • 28
    Publication Date: 1997-08-01
    Description: In the early months of life, infants acquire information about the phonetic properties of their native language simply by listening to adults speak. The acoustic properties of phonetic units in language input to young infants in the United States, Russia, and Sweden were examined. In all three countries, mothers addressing their infants produced acoustically more extreme vowels than they did when addressing adults, resulting in a "stretching" of vowel space. The findings show that language input to infants provides exceptionally well-specified information about the linguistic units that form the building blocks for words.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuhl, P K -- Andruski, J E -- Chistovich, I A -- Chistovich, L A -- Kozhevnikova, E V -- Ryskina, V L -- Stolyarova, E I -- Sundberg, U -- Lacerda, F -- DC 00520/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 1;277(5326):684-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Speech and Hearing Sciences, University of Washington, Box 357920, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9235890" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Infant ; *Language Development ; Mothers ; *Phonetics ; Russia ; Speech Acoustics ; *Speech Perception ; Sweden ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1647-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9206828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Breeding ; Carnivora/*genetics ; Crosses, Genetic ; DNA, Mitochondrial/*genetics ; Dogs/*genetics ; Female ; Haplotypes ; Male
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1553.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411773" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/*therapeutic use ; Controlled Clinical Trials as Topic ; Ethics, Medical ; Female ; HIV Infections/*drug therapy/transmission ; Humans ; Infant ; Infectious Disease Transmission, Vertical ; *Placebos ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Pregnant Women ; Thailand ; Zidovudine/*therapeutic use
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  • 31
    Publication Date: 1997-01-24
    Description: Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mittrucker, H W -- Matsuyama, T -- Grossman, A -- Kundig, T M -- Potter, J -- Shahinian, A -- Wakeham, A -- Patterson, B -- Ohashi, P S -- Mak, T W -- New York, N.Y. -- Science. 1997 Jan 24;275(5299):540-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2C1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999800" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; B-Lymphocytes/*immunology ; Bone Marrow Cells ; Cytotoxicity, Immunologic ; DNA-Binding Proteins/genetics/*physiology ; Female ; Gene Targeting ; Graft vs Host Reaction ; Immunization ; Immunoglobulins/blood ; Interferon Regulatory Factors ; Lymphatic Diseases/etiology ; Lymphocyte Activation ; Lymphocyte Subsets/cytology ; Lymphoid Tissue/cytology ; Male ; Mast-Cell Sarcoma/immunology ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Neoplasm Transplantation ; T-Lymphocytes/*immunology ; T-Lymphocytes, Cytotoxic/immunology ; Transcription Factors/genetics/*physiology
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  • 32
    Publication Date: 1997-06-06
    Description: Pheromones are intraspecific chemical signals important for mate attraction and discrimination. In the fruit fly Drosophila melanogaster, hydrocarbons on the cuticular surface of the animal are sexually dimorphic in both their occurrence and their effects: Female-specific molecules stimulate male sexual excitation, whereas the predominant male-specific molecule tends to inhibit male excitation. Complete feminization of the pheromone mixture produced by males was induced by targeted expression of the transformer gene in adult oenocytes (subcuticular abdominal cells) or by ubiquitous expression during early imaginal life. The resulting flies generally exhibited male heterosexual orientation but elicited homosexual courtship from other males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferveur, J F -- Savarit, F -- O'Kane, C J -- Sureau, G -- Greenspan, R J -- Jallon, J M -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Jun 6;276(5318):1555-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mecanismes de communication, Unite de Recherche Associee-CNRS 1491, Batiment 446, Universite Paris-Sud, 91405, Orsay-Cedex, France. ferveur@ext.jussieu.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9171057" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila melanogaster ; Female ; Gene Expression Regulation, Developmental ; Homosexuality ; Male ; Nuclear Proteins/genetics/physiology ; Recombinant Fusion Proteins ; Sex Attractants/genetics/*physiology ; *Sex Characteristics ; Sex Differentiation ; *Sexual Behavior, Animal/physiology ; Transgenes
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-08-15
    Description: It is hypothesized that collective efficacy, defined as social cohesion among neighbors combined with their willingness to intervene on behalf of the common good, is linked to reduced violence. This hypothesis was tested on a 1995 survey of 8782 residents of 343 neighborhoods in Chicago, Illinois. Multilevel analyses showed that a measure of collective efficacy yields a high between-neighborhood reliability and is negatively associated with variations in violence, when individual-level characteristics, measurement error, and prior violence are controlled. Associations of concentrated disadvantage and residential instability with violence are largely mediated by collective efficacy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sampson, R J -- Raudenbush, S W -- Earls, F -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):918-24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Sociology, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252316" target="_blank"〉PubMed〈/a〉
    Keywords: Chicago ; Female ; Humans ; Male ; Models, Statistical ; *Residence Characteristics ; Social Conditions ; *Social Control, Informal ; *Social Environment ; Social Values ; Socioeconomic Factors ; *Violence
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  • 34
    Publication Date: 1997-04-11
    Description: The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level-dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial-temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gabrieli, J D -- Brewer, J B -- Desmond, J E -- Glover, G H -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):264-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology and Neuroscience Program, Stanford University, Stanford, CA 94305, USA. gabrieli@psych.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9092477" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Female ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; Mental Recall/*physiology ; Temporal Lobe/*physiology
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  • 35
    Publication Date: 1997-12-31
    Description: The lethal yellow (AY/a) mouse has a defect in proopiomelanocortin (POMC) signaling in the brain that leads to obesity, and is resistant to the anorexigenic effects of the hormone leptin. It has been proposed that the weight-reducing effects of leptin are thus transmitted primarily by way of POMC neurons. However, the central effects of defective POMC signaling, and the absence of leptin, on weight gain in double-mutant lethal yellow (AY/a) leptin-deficient (lepob/lepob) mice were shown to be independent and additive. Furthermore, deletion of the leptin gene restored leptin sensitivity to AY/a mice. This result implies that in the AY/a mouse, obesity is independent of leptin action, and resistance to leptin results from desensitization of leptin signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boston, B A -- Blaydon, K M -- Varnerin, J -- Cone, R D -- DK/AR517330/DK/NIDDK NIH HHS/ -- DK02404/DK/NIDDK NIH HHS/ -- HD33703/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1641-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201, USA. Laboratories, Rahway, NJ 07065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374468" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Agouti Signaling Protein ; Alleles ; Animals ; Arcuate Nucleus of Hypothalamus/*metabolism ; Blood Glucose/analysis ; Corticosterone/blood ; Crosses, Genetic ; Eating/drug effects ; Energy Metabolism ; Female ; Homeostasis ; Insulin/blood ; *Intercellular Signaling Peptides and Proteins ; Leptin ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Neurons/metabolism ; Obesity/genetics/*metabolism ; Pro-Opiomelanocortin/*metabolism ; Proteins/genetics/*metabolism/pharmacology ; Signal Transduction ; Weight Gain
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-11-14
    Description: Acting in concert with individual susceptibility, environmental factors such as smoking, diet, and pollutants play a role in most human cancer. However, new molecular evidence indicates that specific groups-characterized by predisposing genetic traits or ethnicity, the very young, and women-may have heightened risk from certain exposures. This is illustrated by molecular epidemiologic studies of environmental carcinogens such as polycyclic aromatic hydrocarbons and aromatic amines. Individual genetic screening for rare high-risk traits or for more common, low-penetrant susceptibility genes is problematic and not routinely recommended. However, knowledge of the full spectrum of both genetic and acquired susceptibility in the population will be instrumental in developing health and regulatory policies that increase protection of the more susceptible groups from risks of environmental carcinogens. This will necessitate revision of current risk assessment methodologies to explicitly account for individual variation in susceptibility to environmental carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perera, F P -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1068-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Environmental Health Sciences, Columbia University School of Public Health, 60 Haven Avenue, B-1, New York, NY 10032, USA. fpp1@columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353182" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Amines/adverse effects ; Carcinogens, Environmental/*adverse effects ; Continental Population Groups ; Female ; *Genetic Predisposition to Disease ; Humans ; Male ; Neoplasms/chemically induced/ethnology/*etiology/genetics/prevention & control ; Nutritional Physiological Phenomena ; Polycyclic Hydrocarbons, Aromatic/adverse effects ; Risk Factors ; *Sex Characteristics
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedrick, Phil -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1744; author reply 1744. doi: 10.1126/science.330.6012.1744-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205652" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Florida ; Inbreeding ; Male ; Population Density ; Puma/*genetics/physiology ; Reproduction ; Texas
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  • 38
    Publication Date: 2011-01-06
    Description: Human social interactions crucially depend on the ability to represent other agents' beliefs even when these contradict our own beliefs, leading to the potentially complex problem of simultaneously holding two conflicting representations in mind. Here, we show that adults and 7-month-olds automatically encode others' beliefs, and that, surprisingly, others' beliefs have similar effects as the participants' own beliefs. In a visual object detection task, participants' beliefs and the beliefs of an agent (whose beliefs were irrelevant to performing the task) both modulated adults' reaction times and infants' looking times. Moreover, the agent's beliefs influenced participants' behavior even after the agent had left the scene, suggesting that participants computed the agent's beliefs online and sustained them, possibly for future predictions about the agent's behavior. Hence, the mere presence of an agent automatically triggers powerful processes of belief computation that may be part of a "social sense" crucial to human societies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kovacs, Agnes Melinda -- Teglas, Erno -- Endress, Ansgar Denis -- New York, N.Y. -- Science. 2010 Dec 24;330(6012):1830-4. doi: 10.1126/science.1190792.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Psychology, Hungarian Academy of Sciences, H-1132 Budapest, Hungary. agneskovacs@mtapi.hu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21205671" target="_blank"〉PubMed〈/a〉
    Keywords: Culture ; Female ; Humans ; Infant ; Male ; Reaction Time ; *Social Perception ; *Theory of Mind ; Young Adult
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  • 39
    Publication Date: 2011-10-29
    Description: Burmese pythons display a marked increase in heart mass after a large meal. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. We found that heart growth in pythons is characterized by myocyte hypertrophy in the absence of cell proliferation and by activation of physiological signal transduction pathways. Despite high levels of circulating lipids, the postprandial python heart does not accumulate triglycerides or fatty acids. Instead, there is robust activation of pathways of fatty acid transport and oxidation combined with increased expression and activity of superoxide dismutase, a cardioprotective enzyme. We also identified a combination of fatty acids in python plasma that promotes physiological heart growth when injected into either pythons or mice.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383835/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383835/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riquelme, Cecilia A -- Magida, Jason A -- Harrison, Brooke C -- Wall, Christopher E -- Marr, Thomas G -- Secor, Stephen M -- Leinwand, Leslie A -- 5K01AR055676/AR/NIAMS NIH HHS/ -- HL050560/HL/NHLBI NIH HHS/ -- K01 AR055676/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 28;334(6055):528-31. doi: 10.1126/science.1210558.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22034436" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Biological Transport ; Boidae/anatomy & histology/genetics/*physiology ; Cardiomegaly ; Cell Size ; Fasting ; Fatty Acids/blood/*metabolism ; Fatty Acids, Monounsaturated/blood/pharmacology ; Fatty Acids, Nonesterified/blood ; Female ; Gene Expression Regulation ; Heart/anatomy & histology/drug effects/*growth & development ; Male ; Myocardium/metabolism/pathology ; Myocytes, Cardiac/cytology ; Myristic Acids/blood/pharmacology ; Oxidation-Reduction ; Palmitic Acid/blood/pharmacology ; Postprandial Period ; Protein Biosynthesis ; Superoxide Dismutase/metabolism ; Triglycerides/blood
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2011 May 6;332(6030):650-1. doi: 10.1126/science.332.6030.650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21551038" target="_blank"〉PubMed〈/a〉
    Keywords: Age Distribution ; Birth Rate/trends ; Censuses ; China ; Educational Status ; Female ; Humans ; Male ; *Population Growth ; Sex Ratio ; Urban Population/statistics & numerical data/trends
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  • 41
    Publication Date: 2011-12-14
    Description: Predator effects on prey demography have traditionally been ascribed solely to direct killing in studies of population ecology and wildlife management. Predators also affect the prey's perception of predation risk, but this has not been thought to meaningfully affect prey demography. We isolated the effects of perceived predation risk in a free-living population of song sparrows by actively eliminating direct predation and used playbacks of predator calls and sounds to manipulate perceived risk. We found that the perception of predation risk alone reduced the number of offspring produced per year by 40%. Our results suggest that the perception of predation risk is itself powerful enough to affect wildlife population dynamics, and should thus be given greater consideration in vertebrate conservation and management.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zanette, Liana Y -- White, Aija F -- Allen, Marek C -- Clinchy, Michael -- New York, N.Y. -- Science. 2011 Dec 9;334(6061):1398-401. doi: 10.1126/science.1210908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada. lzanette@uwo.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22158817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Fear ; Female ; Male ; Nesting Behavior ; Oviposition ; Perception ; Population Dynamics ; Population Growth ; *Predatory Behavior ; *Reproduction ; Risk ; Seasons ; Sparrows/*physiology ; Vocalization, Animal
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Leslie -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):540-3. doi: 10.1126/science.333.6042.540.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798924" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Rate ; Female ; Forecasting ; Humans ; Male ; Parity ; *Population Growth ; Pregnancy
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  • 43
    Publication Date: 2011-07-02
    Description: Human memory is strikingly susceptible to social influences, yet we know little about the underlying mechanisms. We examined how socially induced memory errors are generated in the brain by studying the memory of individuals exposed to recollections of others. Participants exhibited a strong tendency to conform to erroneous recollections of the group, producing both long-lasting and temporary errors, even when their initial memory was strong and accurate. Functional brain imaging revealed that social influence modified the neuronal representation of memory. Specifically, a particular brain signature of enhanced amygdala activity and enhanced amygdala-hippocampus connectivity predicted long-lasting but not temporary memory alterations. Our findings reveal how social manipulation can alter memory and extend the known functions of the amygdala to encompass socially mediated memory distortions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284232/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edelson, Micah -- Sharot, Tali -- Dolan, Raymond J -- Dudai, Yadin -- 078865/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):108-11. doi: 10.1126/science.1203557.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Israel. micah.edelson@weizmann.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719681" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/*physiology ; Brain Mapping ; Female ; *Group Processes ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; *Mental Recall ; Social Behavior ; *Social Conformity
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  • 44
    Publication Date: 2011-06-28
    Description: The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary for synaptic renormalization. We found that, in three Drosophila neuronal circuits, synapse size or number increases after a few hours of wake and decreases only if flies are allowed to sleep. A richer wake experience resulted in both larger synaptic growth and greater sleep need. Finally, we demonstrate that the gene Fmr1 (fragile X mental retardation 1) plays an important role in sleep-dependent synaptic renormalization.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128387/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128387/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bushey, Daniel -- Tononi, Giulio -- Cirelli, Chiara -- DP1 OD000579/OD/NIH HHS/ -- DP1 OD000579-05/OD/NIH HHS/ -- R01 GM075315/GM/NIGMS NIH HHS/ -- R01 GM075315-01A2/GM/NIGMS NIH HHS/ -- R01 GM075315-02/GM/NIGMS NIH HHS/ -- R01 GM075315-03/GM/NIGMS NIH HHS/ -- R01 GM075315-04/GM/NIGMS NIH HHS/ -- R01 GM075315-05/GM/NIGMS NIH HHS/ -- R01 GM075315-05S1/GM/NIGMS NIH HHS/ -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1576-81. doi: 10.1126/science.1202839.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700878" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dendrites/physiology/ultrastructure ; Drosophila Proteins/*genetics/metabolism/physiology ; Drosophila melanogaster/genetics/*physiology ; Female ; Fragile X Mental Retardation Protein/*genetics/physiology ; *Homeostasis ; Male ; Mushroom Bodies/cytology/physiology ; *Neuronal Plasticity ; Neurons/physiology ; Neuropeptides/genetics/metabolism ; Sleep/*physiology ; Sleep Deprivation ; Synapses/*physiology/ultrastructure ; Time Factors
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  • 45
    Publication Date: 2011-04-09
    Description: The spliceosome, a ribonucleoprotein complex that includes proteins and small nuclear RNAs (snRNAs), catalyzes RNA splicing through intron excision and exon ligation to produce mature messenger RNAs, which, in turn serve as templates for protein translation. We identified four point mutations in the U4atac snRNA component of the minor spliceosome in patients with brain and bone malformations and unexplained postnatal death [microcephalic osteodysplastic primordial dwarfism type 1 (MOPD 1) or Taybi-Linder syndrome (TALS); Mendelian Inheritance in Man ID no. 210710]. Expression of a subgroup of genes, possibly linked to the disease phenotype, and minor intron splicing were affected in cell lines derived from TALS patients. Our findings demonstrate a crucial role of the minor spliceosome component U4atac snRNA in early human development and postnatal survival.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edery, Patrick -- Marcaillou, Charles -- Sahbatou, Mourad -- Labalme, Audrey -- Chastang, Joelle -- Touraine, Renaud -- Tubacher, Emmanuel -- Senni, Faiza -- Bober, Michael B -- Nampoothiri, Sheela -- Jouk, Pierre-Simon -- Steichen, Elisabeth -- Berland, Siren -- Toutain, Annick -- Wise, Carol A -- Sanlaville, Damien -- Rousseau, Francis -- Clerget-Darpoux, Francoise -- Leutenegger, Anne-Louise -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):240-3. doi: 10.1126/science.1202205.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hospices Civils de Lyon, Service de Cytogenetique Constitutionnelle, Bron, F-69677, France. patrick.edery@chu-lyon.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474761" target="_blank"〉PubMed〈/a〉
    Keywords: Base Pairing ; Cell Line ; Child, Preschool ; Chromosomes, Human, Pair 2/genetics ; Dwarfism/genetics/metabolism ; Female ; Fetal Growth Retardation/genetics/metabolism ; Humans ; Infant ; Introns ; Inverted Repeat Sequences ; Male ; Microcephaly/genetics/metabolism ; Microtubule-Associated Proteins/genetics ; Nucleic Acid Conformation ; Osteochondrodysplasias/genetics/metabolism ; Pedigree ; *Point Mutation ; RNA Splice Sites ; *RNA Splicing ; RNA, Small Nuclear/chemistry/*genetics/metabolism ; Spliceosomes/*genetics/metabolism
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapais, Bernard -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1276-7. doi: 10.1126/science.1203281.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, University of Montreal, Montreal, Quebec, Canada. bernard.chapais@umontreal.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Cooperative Behavior ; *Cultural Evolution ; *Family ; Female ; Humans ; Male ; Pair Bond ; Pan paniscus ; Pan troglodytes ; *Population Groups ; *Residence Characteristics ; *Social Behavior
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  • 47
    Publication Date: 2011-02-26
    Description: Metarhizium anisopliae infects mosquitoes through the cuticle and proliferates in the hemolymph. To allow M. anisopliae to combat malaria in mosquitoes with advanced malaria infections, we produced recombinant strains expressing molecules that target sporozoites as they travel through the hemolymph to the salivary glands. Eleven days after a Plasmodium-infected blood meal, mosquitoes were treated with M. anisopliae expressing salivary gland and midgut peptide 1 (SM1), which blocks attachment of sporozoites to salivary glands; a single-chain antibody that agglutinates sporozoites; or scorpine, which is an antimicrobial toxin. These reduced sporozoite counts by 71%, 85%, and 90%, respectively. M. anisopliae expressing scorpine and an [SM1](8):scorpine fusion protein reduced sporozoite counts by 98%, suggesting that Metarhizium-mediated inhibition of Plasmodium development could be a powerful weapon for combating malaria.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153607/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153607/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fang, Weiguo -- Vega-Rodriguez, Joel -- Ghosh, Anil K -- Jacobs-Lorena, Marcelo -- Kang, Angray -- St Leger, Raymond J -- 5R21A1079429-02/PHS HHS/ -- R01 AI031478/AI/NIAID NIH HHS/ -- R21 AI079429/AI/NIAID NIH HHS/ -- R21 AI088033/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1074-7. doi: 10.1126/science.1199115.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Maryland, 4112 Plant Sciences Building, College Park, MD 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles gambiae/*microbiology/*parasitology/physiology ; Antibodies, Protozoan/immunology ; Base Sequence ; Cloning, Molecular ; Defensins/genetics/metabolism ; Feeding Behavior ; Female ; Hemolymph/metabolism/microbiology/parasitology ; Humans ; Insect Vectors/*microbiology/*parasitology/physiology ; Malaria, Falciparum/transmission ; Metarhizium/*genetics/physiology ; Molecular Sequence Data ; Oligopeptides/genetics/metabolism ; Organisms, Genetically Modified ; Pest Control, Biological ; Plasmodium falciparum/*physiology ; Protozoan Proteins/immunology ; Salivary Glands/metabolism/parasitology ; Spores, Fungal/physiology ; Sporozoites/physiology ; Transformation, Genetic ; Transgenes
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  • 48
    Publication Date: 2011-05-14
    Description: Mitochondria are maternally transmitted; hence, their genome can only make a direct and adaptive response to selection through females, whereas males represent an evolutionary dead end. In theory, this creates a sex-specific selective sieve, enabling deleterious mutations to accumulate in mitochondrial genomes if they exert male-specific effects. We tested this hypothesis, expressing five mitochondrial variants alongside a standard nuclear genome in Drosophila melanogaster, and found striking sexual asymmetry in patterns of nuclear gene expression. Mitochondrial polymorphism had few effects on nuclear gene expression in females but major effects in males, modifying nearly 10% of transcripts. These were mostly male-biased in expression, with enrichment hotspots in the testes and accessory glands. Our results suggest an evolutionary mechanism that results in mitochondrial genomes harboring male-specific mutation loads.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Innocenti, Paolo -- Morrow, Edward H -- Dowling, Damian K -- New York, N.Y. -- Science. 2011 May 13;332(6031):845-8. doi: 10.1126/science.1201157.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18-D, 75236 Uppsala, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566193" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Drosophila melanogaster/*genetics/physiology ; *Evolution, Molecular ; Female ; Fertility ; *Gene Expression ; Gene Expression Profiling ; Genes, Insect ; Genetic Fitness ; *Genome, Insect ; *Genome, Mitochondrial ; Male ; *Mutation ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Genetic ; Selection, Genetic ; Sex Characteristics ; Transcription, Genetic
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):13. doi: 10.1126/science.1209751.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719646" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/drug ; therapy/economics/epidemiology/prevention & control ; Anti-HIV Agents/therapeutic use ; Biomedical Research ; Female ; Global Health ; Health Expenditures ; *Health Policy/economics ; Humans ; Male ; Pandemics/prevention & control
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  • 50
    Publication Date: 2011-03-12
    Description: The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFalpha-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited selective TNFR binding. PGRN and Atsttrin prevented inflammation in multiple arthritis mouse models and inhibited TNFalpha-activated intracellular signaling. Collectively, these findings demonstrate that PGRN is a ligand of TNFR, an antagonist of TNFalpha signaling, and plays a critical role in the pathogenesis of inflammatory arthritis in mice. They also suggest new potential therapeutic interventions for various TNFalpha-mediated pathologies and conditions, including rheumatoid arthritis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104397/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Wei -- Lu, Yi -- Tian, Qing-Yun -- Zhang, Yan -- Guo, Feng-Jin -- Liu, Guang-Yi -- Syed, Nabeel Muzaffar -- Lai, Yongjie -- Lin, Edward Alan -- Kong, Li -- Su, Jeffrey -- Yin, Fangfang -- Ding, Ai-Hao -- Zanin-Zhorov, Alexandra -- Dustin, Michael L -- Tao, Jian -- Craft, Joseph -- Yin, Zhinan -- Feng, Jian Q -- Abramson, Steven B -- Yu, Xiu-Ping -- Liu, Chuan-ju -- AI43542/AI/NIAID NIH HHS/ -- AR040072/AR/NIAMS NIH HHS/ -- AR050620/AR/NIAMS NIH HHS/ -- AR053210/AR/NIAMS NIH HHS/ -- GM061710/GM/NIGMS NIH HHS/ -- R01 AI030165/AI/NIAID NIH HHS/ -- R01 AI030165-20/AI/NIAID NIH HHS/ -- R01 GM061710/GM/NIGMS NIH HHS/ -- R01 GM061710-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393509" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism/pharmacology/therapeutic use ; Arthritis, Experimental/*drug therapy/*immunology/pathology/physiopathology ; Cartilage, Articular/metabolism/pathology ; Female ; Humans ; Intercellular Signaling Peptides and ; Proteins/chemistry/genetics/*metabolism/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Protein Interaction Domains and Motifs ; Receptors, Tumor Necrosis Factor, Type I/genetics/*metabolism ; Receptors, Tumor Necrosis Factor, Type II/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism/pharmacology/therapeutic use ; Recombinant Proteins/therapeutic use ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology/physiology ; Tumor Necrosis Factor-alpha/*metabolism ; Young Adult
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  • 51
    Publication Date: 2011-09-17
    Description: Neural circuits regulate cytokine production to prevent potentially damaging inflammation. A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-alpha production in spleen by a mechanism requiring acetylcholine signaling through the alpha7 nicotinic acetylcholine receptor expressed on cytokine-producing macrophages. Nerve fibers in spleen lack the enzymatic machinery necessary for acetylcholine production; therefore, how does this neural circuit terminate in cholinergic signaling? We identified an acetylcholine-producing, memory phenotype T cell population in mice that is integral to the inflammatory reflex. These acetylcholine-producing T cells are required for inhibition of cytokine production by vagus nerve stimulation. Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548937/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548937/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosas-Ballina, Mauricio -- Olofsson, Peder S -- Ochani, Mahendar -- Valdes-Ferrer, Sergio I -- Levine, Yaakov A -- Reardon, Colin -- Tusche, Michael W -- Pavlov, Valentin A -- Andersson, Ulf -- Chavan, Sangeeta -- Mak, Tak W -- Tracey, Kevin J -- R01 GM057226/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):98-101. doi: 10.1126/science.1209985. Epub 2011 Sep 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21921156" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*biosynthesis ; Action Potentials ; Animals ; CD4-Positive T-Lymphocytes/*immunology/*metabolism ; Choline O-Acetyltransferase/metabolism ; Cholinergic Agents/metabolism ; Female ; *Immunity, Innate ; Immunologic Memory ; Inflammation ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; *Neuroimmunomodulation ; Norepinephrine/pharmacology ; Receptors, Nicotinic/metabolism ; Signal Transduction ; Spleen/immunology/innervation/metabolism ; T-Lymphocyte Subsets/immunology/metabolism ; Tumor Necrosis Factor-alpha/blood ; Vagus Nerve/*physiology ; Vagus Nerve Stimulation ; alpha7 Nicotinic Acetylcholine Receptor
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fenton, M Brock -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):528-9. doi: 10.1126/science.1209933.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Western Ontario, London, ON N6A 5B7, Canada. bfenton@uwo.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798917" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Communication ; Animals ; Biological Evolution ; Chiroptera/*physiology ; *Echolocation ; Feeding Behavior ; Female ; Flowers ; Insects ; Male ; Plant Leaves/anatomy & histology ; Plant Nectar ; Sensation ; Sound
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reed, John C -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1075-6. doi: 10.1126/science.1215568.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. jreed@sanfordburnham.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22116875" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/*therapeutic use ; *Apoptosis ; Female ; Humans ; Male ; Mitochondria/*physiology ; Neoplasms/*drug therapy/*physiopathology
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leslie, Mitch -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):414-5. doi: 10.1126/science.332.6028.414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512015" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; *Chronic Disease ; *Cytological Techniques ; Diagnostic Services ; *Disease Susceptibility ; Female ; Health Behavior ; Humans ; In Situ Hybridization, Fluorescence ; Life Style ; Male ; Polymerase Chain Reaction ; Telomere/*physiology/*ultrastructure
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Dec 23;334(6063):1604. doi: 10.1126/science.1217831.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22194530" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/*therapeutic use ; Female ; HIV Infections/*drug therapy/*prevention & control ; Humans ; Male
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):310. doi: 10.1126/science.334.6054.310-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021836" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/*metabolism ; Female ; Humans ; *Inflammation ; Macrophages, Peritoneal/*enzymology ; Male ; Neutrophils/*enzymology ; Phosphotransferases (Alcohol Group Acceptor)/*metabolism ; Sepsis/*immunology ; Shock, Septic/*immunology
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  • 57
    Publication Date: 2011-05-28
    Description: Many organisms can predict future events from the statistics of past experience, but humans also excel at making predictions by pure reasoning: integrating multiple sources of information, guided by abstract knowledge, to form rational expectations about novel situations, never directly experienced. Here, we show that this reasoning is surprisingly rich, powerful, and coherent even in preverbal infants. When 12-month-old infants view complex displays of multiple moving objects, they form time-varying expectations about future events that are a systematic and rational function of several stimulus variables. Infants' looking times are consistent with a Bayesian ideal observer embodying abstract principles of object motion. The model explains infants' statistical expectations and classic qualitative findings about object cognition in younger babies, not originally viewed as probabilistic inferences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teglas, Erno -- Vul, Edward -- Girotto, Vittorio -- Gonzalez, Michel -- Tenenbaum, Joshua B -- Bonatti, Luca L -- New York, N.Y. -- Science. 2011 May 27;332(6033):1054-9. doi: 10.1126/science.1196404.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cognitive Development Centre, Central European University, H-1015 Budapest, Hungary.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617069" target="_blank"〉PubMed〈/a〉
    Keywords: Bayes Theorem ; Child Development ; *Cognition ; Female ; Humans ; Infant ; Male ; Models, Statistical ; Monte Carlo Method ; *Probability ; Visual Perception
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):760. doi: 10.1126/science.1216027. Epub 2011 Nov 1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22045832" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Psychological ; *Environment ; Female ; Humans ; Male ; *Prejudice ; *Stereotyping
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Alice S -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):821. doi: 10.1126/science.1203124.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330495" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; *Engineering ; Female ; Humans ; *Science ; *Women, Working
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  • 60
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: This paper discusses emerging demographic patterns and its opportunities and challenges for India. It investigates the specificities in the demographic transition in terms of various demographic parameters and the lack of homogeneity in the transition across states in the country. It presents some opportunities that can arise from having demographic changes, particularly the demographic dividend and interstate migration to overcome labor shortage in some parts. At the same time, there are serious challenges in the form of enhancing human capital development, addressing the issue of skewed sex ratio, and the possible rise in social and political unrest and conflict.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉James, K S -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):576-80. doi: 10.1126/science.1207969.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Population Research Centre, Institute for Social and Economic Change, Bangalore 560072, India. james@isec.ac.in〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798938" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Rate ; *Demography ; Female ; Forecasting ; Humans ; India ; Male ; Mortality ; *Population Density ; *Population Dynamics ; Population Growth ; Sex Ratio
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  • 61
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-11-26
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518432/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518432/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Beth -- Elazar, Zvulun -- R01 CA109618/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1069-70. doi: 10.1126/science.1215480.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Autophagy Research, Department of Internal Medicine, Department of Microbiology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9113, USA. beth.levine@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22116870" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autophagy ; Caenorhabditis elegans/*embryology ; DNA, Mitochondrial/*genetics ; Embryo, Nonmammalian/*physiology ; Female ; *Fertilization ; Male ; Mitochondria/*metabolism ; Phagosomes/*physiology ; Spermatozoa/*ultrastructure
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  • 62
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1549. doi: 10.1126/science.331.6024.1549.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436440" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Breast Neoplasms/diagnosis/prevention & control/therapy ; Canada ; *Delivery of Health Care ; Developing Countries ; Female ; *Health Knowledge, Attitudes, Practice ; Health Services Accessibility ; History, 20th Century ; History, 21st Century ; Humans ; Mexico ; *Neoplasms/diagnosis/therapy ; United States
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  • 63
    Publication Date: 2011-11-05
    Description: Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moreau, Claudia -- Bherer, Claude -- Vezina, Helene -- Jomphe, Michele -- Labuda, Damian -- Excoffier, Laurent -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1148-50. doi: 10.1126/science.1212880. Epub 2011 Nov 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Recherche, Hopital Sainte-Justine, Universite de Montreal, 3175 Cote Sainte-Catherine, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22052972" target="_blank"〉PubMed〈/a〉
    Keywords: *Demography ; Emigration and Immigration ; Family Characteristics ; Female ; Fertility ; *Gene Pool ; Genes ; *Genetic Fitness ; Humans ; Male ; Marriage ; *Pedigree ; *Population Dynamics ; Quebec ; Registries ; Reproduction ; *Selection, Genetic
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  • 64
    Publication Date: 2011-08-13
    Description: Animals that cooperate with nonrelatives represent a challenge to inclusive fitness theory, unless cooperative behavior is shown to provide direct fitness benefits. Inheritance of breeding resources could provide such benefits, but this route to cooperation has been little investigated in the social insects. We show that nest inheritance can explain the presence of unrelated helpers in a classic social insect model, the primitively eusocial wasp Polistes dominulus. We found that subordinate helpers produced more direct offspring than lone breeders, some while still subordinate but most after inheriting the dominant position. Thus, while indirect fitness obtained through helping relatives has been the dominant paradigm for understanding eusociality in insects, direct fitness is vital to explain cooperation in P. dominulus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leadbeater, Ellouise -- Carruthers, Jonathan M -- Green, Jonathan P -- Rosser, Neil S -- Field, Jeremy -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):874-6. doi: 10.1126/science.1205140.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK. ellouise.leadbeater@ioz.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Biological Evolution ; *Cooperative Behavior ; Female ; *Genetic Fitness ; Male ; Microsatellite Repeats ; *Nesting Behavior ; Reproduction ; *Social Behavior ; Wasps/genetics/*physiology
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  • 65
    Publication Date: 2011-01-15
    Description: Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (range 1 to 50%) of all cellular transcripts, a mean 40-fold increase over that in normal tissue. In 15 of 15 human PDACs, alpha satellite transcripts were most abundant and HSATII transcripts were highly specific for cancer. Similar patterns were observed in cancers of the lung, kidney, ovary, colon, and prostate. Derepression of satellite transcripts correlated with overexpression of the long interspersed nuclear element 1 (LINE-1) retrotransposon and with aberrant expression of neuroendocrine-associated genes proximal to LINE-1 insertions. The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701432/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701432/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ting, David T -- Lipson, Doron -- Paul, Suchismita -- Brannigan, Brian W -- Akhavanfard, Sara -- Coffman, Erik J -- Contino, Gianmarco -- Deshpande, Vikram -- Iafrate, A John -- Letovsky, Stan -- Rivera, Miguel N -- Bardeesy, Nabeel -- Maheswaran, Shyamala -- Haber, Daniel A -- CA129933/CA/NCI NIH HHS/ -- L30 CA142210/CA/NCI NIH HHS/ -- P01 CA117969/CA/NCI NIH HHS/ -- R01 CA129933/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):593-6. doi: 10.1126/science.1200801. Epub 2011 Jan 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21233348" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma in Situ/genetics/pathology ; Carcinoma, Pancreatic Ductal/genetics/pathology ; Colonic Neoplasms/genetics/pathology ; DNA Methylation ; DNA, Neoplasm/genetics ; DNA, Satellite/*genetics ; Female ; Gene Expression ; Gene Expression Profiling ; Heterochromatin/chemistry/genetics ; Humans ; Long Interspersed Nucleotide Elements ; Lung Neoplasms/genetics/pathology ; Male ; Mice ; Mice, Nude ; Neoplasms/*genetics/pathology ; Neurosecretory Systems/metabolism ; Ovarian Neoplasms/genetics/pathology ; Pancreatic Neoplasms/*genetics/pathology ; Prostatic Neoplasms/genetics/pathology ; RNA, Neoplasm/*genetics/metabolism ; RNA, Untranslated/*genetics/metabolism ; Transcription, Genetic
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  • 66
    Publication Date: 2011-02-19
    Description: Black bears hibernate for 5 to 7 months a year and, during this time, do not eat, drink, urinate, or defecate. We measured metabolic rate and body temperature in hibernating black bears and found that they suppress metabolism to 25% of basal rates while regulating body temperature from 30 degrees to 36 degrees C, in multiday cycles. Heart rates were reduced from 55 to as few as 9 beats per minute, with profound sinus arrhythmia. After returning to normal body temperature and emerging from dens, bears maintained a reduced metabolic rate for up to 3 weeks. The pronounced reduction and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic suppression during hibernation is independent of lowered body temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toien, Oivind -- Blake, John -- Edgar, Dale M -- Grahn, Dennis A -- Heller, H Craig -- Barnes, Brian M -- HD-00973/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):906-9. doi: 10.1126/science.1199435.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775, USA. otoien@alaska.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330544" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Metabolism ; *Body Temperature ; *Energy Metabolism ; Female ; Heart Rate ; *Hibernation ; Humans ; Male ; *Oxygen Consumption ; Time Factors ; Ursidae/metabolism/*physiology
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forster, Peter -- Renfrew, Colin -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1390-1. doi: 10.1126/science.1205331.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Murray Edwards College, University of Cambridge, Cambridge CB3 0DF, UK. pf223@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903800" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Americas ; Asia ; Chromosomes, Human, Y/*genetics ; Continental Population Groups/*genetics ; *Cultural Evolution ; DNA, Mitochondrial/genetics ; *Emigration and Immigration ; Europe ; Female ; Humans ; India ; *Language ; Male ; Pacific Islands ; Sex Characteristics
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  • 68
    Publication Date: 2011-10-08
    Description: Pathological fasting hypoglycemia in humans is usually explained by excessive circulating insulin or insulin-like molecules or by inborn errors of metabolism impairing liver glucose production. We studied three unrelated children with unexplained, recurrent, and severe fasting hypoglycemia and asymmetrical growth. All were found to carry the same de novo mutation, p.Glu17Lys, in the serine/threonine kinase AKT2, in two cases as heterozygotes and in one case in mosaic form. In heterologous cells, the mutant AKT2 was constitutively recruited to the plasma membrane, leading to insulin-independent activation of downstream signaling. Thus, systemic metabolic disease can result from constitutive, cell-autonomous activation of signaling pathways normally controlled by insulin.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204221/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204221/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hussain, K -- Challis, B -- Rocha, N -- Payne, F -- Minic, M -- Thompson, A -- Daly, A -- Scott, C -- Harris, J -- Smillie, B J L -- Savage, D B -- Ramaswami, U -- De Lonlay, P -- O'Rahilly, S -- Barroso, I -- Semple, R K -- 077016/Wellcome Trust/United Kingdom -- 077016/Z/05/Z/Wellcome Trust/United Kingdom -- 078986/Wellcome Trust/United Kingdom -- 078986/Z/06/Z/Wellcome Trust/United Kingdom -- 080952/Wellcome Trust/United Kingdom -- 080952/Z/06/Z/Wellcome Trust/United Kingdom -- 091551/Wellcome Trust/United Kingdom -- 091551/Z/10/Z/Wellcome Trust/United Kingdom -- 095515/Wellcome Trust/United Kingdom -- G0502115/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2011 Oct 28;334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical and Molecular Genetics Unit, Developmental Endocrinology Research Group, Institute of Child Health, University College London, London WC1N 1EH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21979934" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Cell Membrane/metabolism ; Cell Nucleus/metabolism ; Child ; Female ; Growth ; HeLa Cells ; Heterozygote ; Humans ; Hypoglycemia/*genetics/*metabolism ; Insulin/blood/metabolism ; Male ; Mosaicism ; *Mutation ; Pedigree ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins c-akt/chemistry/*genetics/metabolism ; Signal Transduction
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  • 69
    Publication Date: 2011-11-05
    Description: Plain-tailed wrens (Pheugopedius euophrys) cooperate to produce a duet song in which males and females rapidly alternate singing syllables. We examined how sensory information from each wren is used to coordinate singing between individuals for the production of this cooperative behavior. Previous findings in nonduetting songbird species suggest that premotor circuits should encode each bird's own contribution to the duet. In contrast, we find that both male and female wrens encode the combined cooperative output of the pair of birds. Further, behavior and neurophysiology show that both sexes coordinate the timing of their singing based on feedback from the partner and suggest that females may lead the duet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fortune, Eric S -- Rodriguez, Carlos -- Li, David -- Ball, Gregory F -- Coleman, Melissa J -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):666-70. doi: 10.1126/science.1209867.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA. eric.fortune@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053048" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Male ; Neurons/*physiology ; Songbirds/*physiology ; Vocalization, Animal/physiology
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  • 70
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryerson, William N -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1265; author reply 1265. doi: 10.1126/science.331.6022.1265-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21393528" target="_blank"〉PubMed〈/a〉
    Keywords: *Contraception ; *Family Planning Services ; Female ; *Health Communication ; Health Services Accessibility ; Humans ; Male
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  • 71
    Publication Date: 2011-09-03
    Description: RNA can act as a regulator of gene expression with roles in transposon silencing, antiviral defense, and cell fate determination. Here, we show that in Caenorhabditis elegans a maternal transcript of the sex-determining gene fem-1 is required to license expression of a wild-type fem-1 allele in the zygotic germ line. Females homozygous for fem-1 deletions produce heterozygous offspring exhibiting germline feminization, reduced fem-1 activity, and transcript accumulation. Injection of fem-1 RNA incapable of encoding a protein into the maternal germ line rescues this defect in the progeny. The defect in zygotic fem-1 expression is heritable, suggesting that the gene is subject to epigenetic silencing that is prevented by maternal fem-1 transcripts. This mechanism may contribute to protecting the identity and integrity of the germ line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Cheryl L -- Spence, Andrew M -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1311-4. doi: 10.1126/science.1208178.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, Collaborative Program in Developmental Biology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885785" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Caenorhabditis elegans/cytology/*genetics/physiology ; Caenorhabditis elegans Proteins/*genetics/metabolism ; Cell Cycle Proteins/*genetics/metabolism ; Crosses, Genetic ; *Epigenesis, Genetic ; Female ; Gene Deletion ; *Gene Silencing ; Germ Cells/*metabolism ; Heterozygote ; Homozygote ; Male ; Phenotype ; RNA, Helminth/*genetics ; RNA, Messenger/genetics ; Sex Determination Processes/*genetics ; Spermatogenesis
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, Bruno S -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):542-3. doi: 10.1126/science.1201060.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Warwick Business School, University of Warwick, Coventry CV4 7AL, UK. bruno.frey@econ.uzh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292959" target="_blank"〉PubMed〈/a〉
    Keywords: Emotions ; Female ; *Happiness ; Health ; Humans ; *Longevity ; Longitudinal Studies ; Male
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  • 73
    Publication Date: 2011-03-19
    Description: Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations, we previously developed omecamtiv mecarbil, a small-molecule, direct activator of cardiac myosin. Here, we show that it binds to the myosin catalytic domain and operates by an allosteric mechanism to increase the transition rate of myosin into the strongly actin-bound force-generating state. Paradoxically, it inhibits adenosine 5'-triphosphate turnover in the absence of actin, which suggests that it stabilizes an actin-bound conformation of myosin. In animal models, omecamtiv mecarbil increases cardiac function by increasing the duration of ejection without changing the rates of contraction. Cardiac myosin activation may provide a new therapeutic approach for systolic heart failure.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090309/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090309/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malik, Fady I -- Hartman, James J -- Elias, Kathleen A -- Morgan, Bradley P -- Rodriguez, Hector -- Brejc, Katjusa -- Anderson, Robert L -- Sueoka, Sandra H -- Lee, Kenneth H -- Finer, Jeffrey T -- Sakowicz, Roman -- Baliga, Ramesh -- Cox, David R -- Garard, Marc -- Godinez, Guillermo -- Kawas, Raja -- Kraynack, Erica -- Lenzi, David -- Lu, Pu Ping -- Muci, Alexander -- Niu, Congrong -- Qian, Xiangping -- Pierce, Daniel W -- Pokrovskii, Maria -- Suehiro, Ion -- Sylvester, Sheila -- Tochimoto, Todd -- Valdez, Corey -- Wang, Wenyue -- Katori, Tatsuo -- Kass, David A -- Shen, You-Tang -- Vatner, Stephen F -- Morgans, David J -- 1-R43-HL-66647-1/HL/NHLBI NIH HHS/ -- R01 HL106511/HL/NHLBI NIH HHS/ -- R43 HL066647/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 18;331(6023):1439-43. doi: 10.1126/science.1200113.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Preclinical Research and Development, Cytokinetics, Inc., South San Francisco, CA 94080, USA. fmalik@cytokinetics.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21415352" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/metabolism ; Actins/metabolism ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Adrenergic beta-Agonists/pharmacology ; Allosteric Regulation ; Animals ; Binding Sites ; Calcium/metabolism ; Cardiac Myosins/chemistry/*metabolism ; Cardiac Output/drug effects ; Dogs ; Female ; Heart Failure, Systolic/*drug therapy/physiopathology ; Isoproterenol/pharmacology ; Male ; Myocardial Contraction/*drug effects ; Myocytes, Cardiac/*drug effects/physiology ; Phosphates/metabolism ; Protein Binding ; Protein Conformation ; Protein Isoforms/chemistry/metabolism ; Rats ; Rats, Sprague-Dawley ; Urea/*analogs & derivatives/chemistry/metabolism/pharmacology ; Ventricular Function, Left/drug effects
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):555-7. doi: 10.1126/science.333.6042.555.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798932" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *Demography ; Female ; Germany ; Humans ; India ; Male ; Mexico ; Thailand ; Uganda
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Panksepp, Jaak -- New York, N.Y. -- Science. 2011 Dec 9;334(6061):1358-9. doi: 10.1126/science.1216480.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Study of Animal Well-Being, Department of Comparative Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA. jpanksepp@vetmed.wsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22158811" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; *Empathy ; Female ; Male ; *Social Behavior ; *Stress, Psychological
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  • 76
    Publication Date: 2011-02-12
    Description: Memory B cells formed in response to microbial antigens provide immunity to later infections; however, the inability to detect rare endogenous antigen-specific cells limits current understanding of this process. Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM. The more numerous IgM(+) cells were longer lived than the swIg(+) cells. However, swIg(+) memory cells dominated the secondary response because of the capacity to become activated in the presence of neutralizing serum immunoglobulin. Thus, we propose that memory relies on swIg(+) cells until they disappear and serum immunoglobulin falls to a low level, in which case memory resides with durable IgM(+) reserves.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993090/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993090/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pape, Kathryn A -- Taylor, Justin J -- Maul, Robert W -- Gearhart, Patricia J -- Jenkins, Marc K -- F32 AI091033/AI/NIAID NIH HHS/ -- R01 AI036914/AI/NIAID NIH HHS/ -- R01 AI039614/AI/NIAID NIH HHS/ -- R37 AI027998/AI/NIAID NIH HHS/ -- T32 CA009138/CA/NCI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Mar 4;331(6021):1203-7. doi: 10.1126/science.1201730. Epub 2011 Feb 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310965" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/immunology ; Antigens, CD38/analysis ; B-Lymphocyte Subsets/*immunology ; Cell Survival ; Female ; Germinal Center/cytology/immunology ; Immunization ; *Immunoglobulin Class Switching ; Immunoglobulin M/genetics/*immunology ; *Immunologic Memory ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Phycocyanin/immunology ; Phycoerythrin/immunology ; Spleen/cytology/immunology
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  • 77
    Publication Date: 2011-02-12
    Description: Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two recurrent somatic mutations in and near the selectivity filter of the potassium (K(+)) channel KCNJ5 that are present in 8 of 22 human APAs studied. Both produce increased sodium (Na(+)) conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium (Ca(2+)) entry, the signal for aldosterone production and cell proliferation. Similarly, we identify an inherited KCNJ5 mutation that produces increased Na(+) conductance in a Mendelian form of severe aldosteronism and massive bilateral adrenal hyperplasia. These findings explain pathogenesis in a subset of patients with severe hypertension and implicate loss of K(+) channel selectivity in constitutive cell proliferation and hormone production.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371087/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371087/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi, Murim -- Scholl, Ute I -- Yue, Peng -- Bjorklund, Peyman -- Zhao, Bixiao -- Nelson-Williams, Carol -- Ji, Weizhen -- Cho, Yoonsang -- Patel, Aniruddh -- Men, Clara J -- Lolis, Elias -- Wisgerhof, Max V -- Geller, David S -- Mane, Shrikant -- Hellman, Per -- Westin, Gunnar -- Akerstrom, Goran -- Wang, Wenhui -- Carling, Tobias -- Lifton, Richard P -- DK54983/DK/NIDDK NIH HHS/ -- K01 AR060300/AR/NIAMS NIH HHS/ -- T32 GM007205/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):768-72. doi: 10.1126/science.1198785.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21311022" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Neoplasms/*genetics/metabolism/pathology ; Adrenal Glands/pathology ; Adrenocortical Adenoma/*genetics/metabolism/pathology ; Aldosterone/*metabolism ; Cell Line ; Cell Proliferation ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium ; Channels/chemistry/*genetics/metabolism ; Humans ; Hyperaldosteronism/*genetics/metabolism/pathology ; Hyperplasia ; Hypertension/*genetics/metabolism ; Male ; Mutant Proteins/chemistry/genetics/metabolism ; *Mutation ; Potassium/metabolism ; Protein Multimerization ; Sodium/metabolism ; Zona Glomerulosa/metabolism/pathology
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  • 78
    Publication Date: 2011-04-16
    Description: How do animals initiate voluntary behavior? A key phenomenon in neuroscience is the readiness or preparatory neural activity in specific regions of the animal brain. The neurons and synaptic mechanisms mediating this activity are unknown. We found that the readiness discharge is shaped by sequential synaptic excitation and inhibition in the brain of crayfish (Procambarus clarkii). The readiness discharge neurons extended axon collaterals that appeared to activate recurring local interneurons. Therefore, we propose that the readiness discharge is formed by sequential synaptic events within the brain without feedback signals from downstream ganglia. The circuit involved is suited for signal processing for self-generated voluntary initiation of behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kagaya, Katsushi -- Takahata, Masakazu -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):365-8. doi: 10.1126/science.1202244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. kagaya@sci.hokudai.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493864" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Astacoidea/*physiology ; Axons/physiology ; Brain/physiology ; Electromyography ; Female ; Ganglia, Invertebrate/physiology ; Interneurons/*physiology ; Locomotion/*physiology ; Male ; Membrane Potentials ; Motor Activity/*physiology ; Muscles/physiology ; Neural Inhibition ; Neural Pathways ; Neurons/cytology/*physiology ; Synapses/*physiology
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Funder, John W -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):685-6. doi: 10.1126/science.1202887.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Prince Henry's Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia. john.funder@princehenrys.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21310991" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Neoplasms/*genetics/physiopathology ; Adrenal Glands/pathology ; Adrenocortical Adenoma/*genetics/physiopathology ; Aldosterone/*metabolism ; Animals ; Disease Models, Animal ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/*genetics/metabolism ; Humans ; Hyperaldosteronism/*genetics/physiopathology ; Hyperplasia ; Hypertension/physiopathology ; Male ; Mice ; Mutation
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gadagkar, Raghavendra -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):833-4. doi: 10.1126/science.1210420.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Ecological Sciences, Indian Institute of Science, Bangalore, 560012 India. ragh@ces.iisc.ernet.in〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836006" target="_blank"〉PubMed〈/a〉
    Keywords: Altruism ; Animals ; *Behavior, Animal ; *Biological Evolution ; Female ; Genetic Fitness ; Microsatellite Repeats ; Nesting Behavior ; Reproduction ; Selection, Genetic ; *Social Behavior ; Wasps/genetics/*physiology
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  • 81
    Publication Date: 2011-01-22
    Description: A sexually mature individual of Darwinopterus preserved together with an egg from the Jurassic of China provides direct evidence of gender in pterosaurs and insights into the reproductive biology of these extinct fliers. This new find and several other examples of Darwinopterus demonstrate that males of this pterosaur had a relatively small pelvis and a large cranial crest, whereas females had a relatively large pelvis and no crest. The ratio of egg mass to adult mass is relatively low, as in extant reptiles, and is comparable to values for squamates. A parchment-like eggshell points to burial and significant uptake of water after oviposition. This evidence for low parental investment contradicts the widespread assumption that reproduction in pterosaurs was like that of birds and shows that it was essentially like that of reptiles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Junchang -- Unwin, David M -- Deeming, D Charles -- Jin, Xingsheng -- Liu, Yongqing -- Ji, Qiang -- New York, N.Y. -- Science. 2011 Jan 21;331(6015):321-4. doi: 10.1126/science.1197323.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China. lujc2008@126.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21252343" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/anatomy & histology ; China ; Egg Shell ; Female ; *Fossils ; Male ; Oviposition ; *Ovum ; Pelvis/anatomy & histology ; Phylogeny ; *Reproduction ; Reptiles/*anatomy & histology/classification/*physiology ; Sex Characteristics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-10
    Description: During courtship flights, males of some hummingbird species produce diverse sounds with tail feathers of varying shapes. We show that these sounds are produced by air flowing past a feather, causing it to aeroelastically flutter and generate flutter-induced sound. Scanning laser doppler vibrometery and high-speed video of individual feathers of different sizes and shapes in a wind tunnel revealed multiple vibratory modes that produce a range of acoustic frequencies and harmonic structures. Neighboring feathers can be aerodynamically coupled and flutter either at the same frequency, resulting in sympathetic vibrations that increase loudness, or at different frequencies, resulting in audible interaction frequencies. Aeroelastic flutter is intrinsic to stiff airfoils such as feathers and thus explains tonal sounds that are common in bird flight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, Christopher J -- Elias, Damian O -- Prum, Richard O -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1430-3. doi: 10.1126/science.1205222.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Post Office Box 208105, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903810" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Biological Evolution ; Birds/anatomy & histology/*physiology ; Feathers/anatomy & histology/*physiology ; Female ; Flight, Animal ; Male ; Mating Preference, Animal ; Movement ; *Sound ; Tail/physiology ; Vibration ; Wind
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):548-9. doi: 10.1126/science.333.6042.548.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798927" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Rate ; Contraception/*utilization ; Developing Countries ; *Family Characteristics ; *Family Planning Services ; Female ; Humans ; Male
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  • 84
    Publication Date: 2011-05-28
    Description: With data from 33 nations, we illustrate the differences between cultures that are tight (have many strong norms and a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of deviant behavior). Tightness-looseness is part of a complex, loosely integrated multilevel system that comprises distal ecological and historical threats (e.g., high population density, resource scarcity, a history of territorial conflict, and disease and environmental threats), broad versus narrow socialization in societal institutions (e.g., autocracy, media regulations), the strength of everyday recurring situations, and micro-level psychological affordances (e.g., prevention self-guides, high regulatory strength, need for structure). This research advances knowledge that can foster cross-cultural understanding in a world of increasing global interdependence and has implications for modeling cultural change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelfand, Michele J -- Raver, Jana L -- Nishii, Lisa -- Leslie, Lisa M -- Lun, Janetta -- Lim, Beng Chong -- Duan, Lili -- Almaliach, Assaf -- Ang, Soon -- Arnadottir, Jakobina -- Aycan, Zeynep -- Boehnke, Klaus -- Boski, Pawel -- Cabecinhas, Rosa -- Chan, Darius -- Chhokar, Jagdeep -- D'Amato, Alessia -- Ferrer, Montse -- Fischlmayr, Iris C -- Fischer, Ronald -- Fulop, Marta -- Georgas, James -- Kashima, Emiko S -- Kashima, Yoshishima -- Kim, Kibum -- Lempereur, Alain -- Marquez, Patricia -- Othman, Rozhan -- Overlaet, Bert -- Panagiotopoulou, Penny -- Peltzer, Karl -- Perez-Florizno, Lorena R -- Ponomarenko, Larisa -- Realo, Anu -- Schei, Vidar -- Schmitt, Manfred -- Smith, Peter B -- Soomro, Nazar -- Szabo, Erna -- Taveesin, Nalinee -- Toyama, Midori -- Van de Vliert, Evert -- Vohra, Naharika -- Ward, Colleen -- Yamaguchi, Susumu -- New York, N.Y. -- Science. 2011 May 27;332(6033):1100-4. doi: 10.1126/science.1197754.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Maryland, College Park, MD 20742, USA. mgelfand@psyc.umd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21617077" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Behavior ; *Cross-Cultural Comparison ; *Cultural Characteristics ; Female ; Government ; Humans ; Male ; Permissiveness ; Political Systems ; Population Density ; *Social Behavior ; *Social Conformity ; Social Control, Formal ; *Social Values ; Young Adult
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  • 85
    Publication Date: 2011-01-08
    Description: Emotional tearing is a poorly understood behavior that is considered uniquely human. In mice, tears serve as a chemosignal. We therefore hypothesized that human tears may similarly serve a chemosignaling function. We found that merely sniffing negative-emotion-related odorless tears obtained from women donors induced reductions in sexual appeal attributed by men to pictures of women's faces. Moreover, after sniffing such tears, men experienced reduced self-rated sexual arousal, reduced physiological measures of arousal, and reduced levels of testosterone. Finally, functional magnetic resonance imaging revealed that sniffing women's tears selectively reduced activity in brain substrates of sexual arousal in men.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelstein, Shani -- Yeshurun, Yaara -- Rozenkrantz, Liron -- Shushan, Sagit -- Frumin, Idan -- Roth, Yehudah -- Sobel, Noam -- New York, N.Y. -- Science. 2011 Jan 14;331(6014):226-30. doi: 10.1126/science.1198331. Epub 2011 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212322" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affect ; *Arousal ; Brain/*physiology ; Double-Blind Method ; *Emotions ; Face ; Female ; Humans ; Hypothalamus/physiology ; Magnetic Resonance Imaging ; Male ; Odors ; Pheromones, Human/*analysis ; Saliva/chemistry ; Sex Characteristics ; *Sexual Behavior ; Smell ; Tears/*chemistry ; Temporal Lobe/physiology ; Testosterone/*analysis ; Young Adult
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  • 86
    Publication Date: 2011-02-26
    Description: The fire ant Solenopsis invicta is a significant pest that was inadvertently introduced into the southern United States almost a century ago and more recently into California and other regions of the world. An assessment of genetic variation at a diverse set of molecular markers in 2144 fire ant colonies from 75 geographic sites worldwide revealed that at least nine separate introductions of S. invicta have occurred into newly invaded areas and that the main southern U.S. population is probably the source of all but one of these introductions. The sole exception involves a putative serial invasion from the southern United States to California to Taiwan. These results illustrate in stark fashion a severe negative consequence of an increasingly massive and interconnected global trade and travel system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ascunce, Marina S -- Yang, Chin-Cheng -- Oakey, Jane -- Calcaterra, Luis -- Wu, Wen-Jer -- Shih, Cheng-Jen -- Goudet, Jerome -- Ross, Kenneth G -- Shoemaker, DeWayne -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1066-8. doi: 10.1126/science.1198734.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉USDA-ARS Center for Medical, Agricultural, and Veterinary Entomology, 1600/1700 Southwest 23rd Drive, Gainesville, FL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ants/genetics ; Asia ; Australia ; Bayes Theorem ; Commerce ; Computer Simulation ; DNA, Mitochondrial/genetics ; Female ; Genes, Insect ; Genetic Variation ; Genotype ; Haplotypes ; *Introduced Species ; Male ; Microsatellite Repeats ; Molecular Sequence Data ; Population Dynamics ; Sequence Analysis, DNA ; South America ; Travel ; United States
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-07-30
    Description: Almost universally, women with higher levels of education have fewer children. Better education is associated with lower mortality, better health, and different migration patterns. Hence, the global population outlook depends greatly on further progress in education, particularly of young women. By 2050, the highest and lowest education scenarios--assuming identical education-specific fertility rates--result in world population sizes of 8.9 and 10.0 billion, respectively. Better education also matters for human development, including health, economic growth, and democracy. Existing methods of multi-state demography can quantitatively integrate education into standard demographic analysis, thus adding the "quality" dimension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutz, Wolfgang -- KC, Samir -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):587-92. doi: 10.1126/science.1206964.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wittgenstein Centre for Demography and Global Human Capital, Vienna A1090, Austria. lutz@iiasa.ac.at〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798940" target="_blank"〉PubMed〈/a〉
    Keywords: Age Distribution ; Birth Rate ; Developed Countries ; *Economic Development ; *Educational Status ; Female ; Forecasting ; *Health Status ; Humans ; Male ; Mortality ; *Population Dynamics ; Population Growth ; *Quality of Life ; Sex Distribution
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  • 88
    Publication Date: 2011-07-19
    Description: In social hierarchies, dominant individuals experience reproductive and health benefits, but the costs of social dominance remain a topic of debate. Prevailing hypotheses predict that higher-ranking males experience higher testosterone and glucocorticoid (stress hormone) levels than lower-ranking males when hierarchies are unstable but not otherwise. In this long-term study of rank-related stress in a natural population of savannah baboons (Papio cynocephalus), high-ranking males had higher testosterone and lower glucocorticoid levels than other males, regardless of hierarchy stability. The singular exception was for the highest-ranking (alpha) males, who exhibited both high testosterone and high glucocorticoid levels. In particular, alpha males exhibited much higher stress hormone levels than second-ranking (beta) males, suggesting that being at the very top may be more costly than previously thought.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433837/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433837/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gesquiere, Laurence R -- Learn, Niki H -- Simao, M Carolina M -- Onyango, Patrick O -- Alberts, Susan C -- Altmann, Jeanne -- P01 AG031719/AG/NIA NIH HHS/ -- P30 AG024361/AG/NIA NIH HHS/ -- R01 AG034513/AG/NIA NIH HHS/ -- R01-AG034513/AG/NIA NIH HHS/ -- R03 MH065294/MH/NIMH NIH HHS/ -- R03 MH65294/MH/NIMH NIH HHS/ -- R24 HD047879/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 15;333(6040):357-60. doi: 10.1126/science.1207120.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. lgesquie@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21764751" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animals ; Behavior, Animal ; Dominance-Subordination ; Feces/chemistry ; Female ; Glucocorticoids/analysis ; *Hierarchy, Social ; Kenya ; Male ; Papio cynocephalus/*physiology/*psychology ; Sexual Behavior, Animal ; *Social Dominance ; *Stress, Psychological ; Testosterone/analysis
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  • 89
    Publication Date: 2011-04-02
    Description: Waves of cyclin synthesis and degradation regulate the activity of Cdc2 protein kinase during the cell cycle. Cdc2 inactivation by Wee1B-mediated phosphorylation is necessary for arrest of the oocyte at G2-prophase, but it is unclear whether this regulation functions later during the metaphase-to-anaphase transition. We show that reactivation of a Wee1B pathway triggers the decrease in Cdc2 activity during egg activation. When Wee1B is down-regulated, oocytes fail to form a pronucleus in response to Ca(2+) signals. Calcium-calmodulin-dependent kinase II (CaMKII) activates Wee1B, and CaMKII-driven exit from metaphase II is inhibited by Wee1B down-regulation, demonstrating that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104668/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104668/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oh, Jeong Su -- Susor, Andrej -- Conti, Marco -- GM080527-05/GM/NIGMS NIH HHS/ -- HD052909/HD/NICHD NIH HHS/ -- R01 GM080527/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):462-5. doi: 10.1126/science.1199211. Epub 2011 Mar 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143-0556, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21454751" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CDC2 Protein Kinase/antagonists & inhibitors/metabolism ; Calcium/metabolism ; Calcium Signaling ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cell Cycle Proteins/genetics/*metabolism ; Cyclin B/genetics/metabolism ; Down-Regulation ; Female ; Gene Knockdown Techniques ; Maturation-Promoting Factor/metabolism ; *Meiosis ; *Metaphase ; Mice ; Mice, Inbred C57BL ; Oocytes/*physiology ; Phosphorylation ; Protein-Tyrosine Kinases/genetics/*metabolism ; RNA, Messenger/genetics/metabolism
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  • 90
    Publication Date: 2011-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):582-3. doi: 10.1126/science.334.6056.582-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053021" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group/*genetics ; *Chromosomes, Human, X ; Female ; Gene Dosage ; *Genetic Variation ; Genome, Human ; Humans ; Male ; Pilot Projects ; Polymorphism, Single Nucleotide
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Leij, Marco J -- New York, N.Y. -- Science. 2011 Dec 2;334(6060):1220-1. doi: 10.1126/science.1214836.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Nonlinear Dynamics in Economics and Finance, University of Amsterdam, 1018 XE Amsterdam, Netherlands. m.j.vanderleij@uva.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22144610" target="_blank"〉PubMed〈/a〉
    Keywords: *Diet Records ; Female ; *Health Behavior ; Humans ; *Internet ; *Interpersonal Relations ; Male ; *Obesity ; *Social Networking ; *Social Support
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  • 92
    Publication Date: 2011-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):582. doi: 10.1126/science.334.6056.582-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22053020" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Rate ; Canada ; *Emigrants and Immigrants ; Emigration and Immigration/*history ; Female ; Gravidity ; History, 17th Century ; History, 18th Century ; Humans ; Male ; Quebec
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Doren, Mark -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):829-30. doi: 10.1126/science.1210282.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. vandoren@jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila/embryology/*genetics/physiology ; Drosophila Proteins/*genetics/physiology ; Female ; Gametogenesis ; Gene Expression Regulation, Developmental ; Germ Cells/*physiology ; Gonads/*cytology/embryology ; Humans ; Male ; RNA-Binding Proteins/*genetics/physiology ; Sex Chromosomes ; *Sex Determination Processes
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  • 94
    Publication Date: 2011-08-13
    Description: Viviparity is known in several clades of Mesozoic aquatic reptiles, but evidence for it is lacking in the Plesiosauria. Here, we report a Late Cretaceous plesiosaur fossil consisting of a fetus preserved within an adult of the same taxon. We interpret this occurrence as a gravid female and unborn young and hence as definitive evidence for plesiosaur viviparity. Quantitative analysis indicates that plesiosaurs gave birth to large, probably single progeny. The combination of viviparity, large offspring size, and small brood number differs markedly from the pattern seen in other marine reptiles but does resemble the K-selected strategy of all extant marine mammals and a few extant lizards. Plesiosaurs may have shared other life history traits with these clades, such as sociality and maternal care.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Keefe, F R -- Chiappe, L M -- New York, N.Y. -- Science. 2011 Aug 12;333(6044):870-3. doi: 10.1126/science.1205689.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Marshall University, Huntington, WV 25755, USA. okeefef@marshall.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21836013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones ; Embryo, Nonmammalian/anatomy & histology ; Female ; *Fossils ; Reptiles/anatomy & histology/classification/embryology/*physiology ; *Viviparity, Nonmammalian
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1370-2. doi: 10.1126/science.333.6048.1370. Epub 2011 Sep 8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903788" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/anatomy & histology ; Brain/anatomy & histology ; Female ; *Fossils ; Hand/anatomy & histology ; *Hominidae/anatomy & histology/classification ; Humans ; Male ; Pelvic Bones/anatomy & histology ; Skeleton ; Skull/anatomy & histology ; South Africa
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2011 Aug 26;333(6046):1086. doi: 10.1126/science.333.6046.1086.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868647" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Female ; *Fossils ; *Genes, MHC Class I ; HLA-B Antigens/*genetics ; HLA-C Antigens/*genetics ; Hominidae/*genetics/*immunology ; Humans
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
    Publication Date: 2011-10-15
    Description: To establish chronic infections, viruses must develop strategies to evade the host's immune responses. Many retroviruses, including mouse mammary tumor virus (MMTV), are transmitted most efficiently through mucosal surfaces rich in microbiota. We found that MMTV, when ingested by newborn mice, stimulates a state of unresponsiveness toward viral antigens. This process required the intestinal microbiota, as antibiotic-treated mice or germ-free mice did not transmit infectious virus to their offspring. MMTV-bound bacterial lipopolysaccharide triggered Toll-like receptor 4 and subsequent interleukin-6 (IL-6)-dependent induction of the inhibitory cytokine IL-10. Thus, MMTV has evolved to rely on the interaction with the microbiota to induce an immune evasion pathway. Together, these findings reveal the fundamental importance of commensal microbiota in viral infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519937/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519937/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kane, Melissa -- Case, Laure K -- Kopaskie, Karyl -- Kozlova, Alena -- MacDearmid, Cameron -- Chervonsky, Alexander V -- Golovkina, Tatyana V -- AI082418/AI/NIAID NIH HHS/ -- AI090084/AI/NIAID NIH HHS/ -- CA100383/CA/NCI NIH HHS/ -- DK42086/DK/NIDDK NIH HHS/ -- P30 CA014599/CA/NCI NIH HHS/ -- R01 AI090084/AI/NIAID NIH HHS/ -- R01 CA134667/CA/NCI NIH HHS/ -- R56 AI090084/AI/NIAID NIH HHS/ -- T32 AI065382-01/AI/NIAID NIH HHS/ -- T32GM007183/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):245-9. doi: 10.1126/science.1210718.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Anti-Bacterial Agents/pharmacology ; Antibodies, Viral/biosynthesis ; Antigens, Viral/immunology ; *Bacterial Physiological Phenomena ; Female ; Germ-Free Life ; *Immune Evasion ; Interleukin-10/genetics/metabolism ; Intestinal Mucosa/*virology ; Intestines/*microbiology ; Lipopolysaccharides/immunology/metabolism ; Mammary Tumor Virus, Mouse/*immunology/*pathogenicity ; *Metagenome ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Retroviridae Infections/immunology/*transmission/virology ; Specific Pathogen-Free Organisms ; Toll-Like Receptor 4/immunology/metabolism ; Tumor Virus Infections/immunology/transmission/virology ; Virus Replication
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2011-09-03
    Description: Ionic flux mediates essential physiological and behavioral functions in defined cell populations. Cell type-specific activators of diverse ionic conductances are needed for probing these effects. We combined chemistry and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacologic selectivity and divergent functional properties. The LGICs and their small-molecule effectors were able to activate a range of ionic conductances in genetically specified cell types. LGICs constructed for neuronal perturbation could be used to selectively manipulate neuron activity in mammalian brains in vivo. The diversity of ion channel tools accessible from this approach will be useful for examining the relationship between neuronal activity and animal behavior, as well as for cell biological and physiological applications requiring chemical control of ion conductance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210548/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210548/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnus, Christopher J -- Lee, Peter H -- Atasoy, Deniz -- Su, Helen H -- Looger, Loren L -- Sternson, Scott M -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Sep 2;333(6047):1292-6. doi: 10.1126/science.1206606.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21885782" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzamides/chemistry/metabolism/pharmacology ; Bicyclo Compounds/chemistry/metabolism/pharmacology ; Brain/cytology/physiology ; Feeding Behavior ; Female ; HEK293 Cells ; Humans ; Ion Channel Gating ; Ligand-Gated Ion Channels/chemistry/*genetics/*metabolism ; Ligands ; Membrane Potentials ; Mice ; Mice, Inbred C57BL ; Mutagenesis ; Neurons/*physiology ; Patch-Clamp Techniques ; Protein Binding ; *Protein Engineering ; Protein Structure, Tertiary ; Quinuclidines/chemistry/metabolism/pharmacology ; Receptors, Glycine/genetics/metabolism ; Receptors, Nicotinic/chemistry/genetics/metabolism ; Receptors, Serotonin, 5-HT3/genetics/metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Small Molecule Libraries ; Stereoisomerism ; alpha7 Nicotinic Acetylcholine Receptor
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaughan, William -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1501-2; author reply 1502-3. doi: 10.1126/science.332.6037.1501-c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700852" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group ; European Continental Ancestry Group ; Female ; Humans ; Male ; *Prejudice ; Research Design ; *Stereotyping
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2011-08-27
    Description: Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide and that can cause considerable morbidity. To study the genetic basis of this tumor type, we examined 18 uterine leiomyomas derived from 17 different patients by exome sequencing and identified tumor-specific mutations in the mediator complex subunit 12 (MED12) gene in 10. Through analysis of 207 additional tumors, we determined that MED12 is altered in 70% (159 of 225) of tumors from a total of 80 patients. The Mediator complex is a 26-subunit transcriptional regulator that bridges DNA regulatory sequences to the RNA polymerase II initiation complex. All mutations resided in exon 2, suggesting that aberrant function of this region of MED12 contributes to tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makinen, Netta -- Mehine, Miika -- Tolvanen, Jaana -- Kaasinen, Eevi -- Li, Yilong -- Lehtonen, Heli J -- Gentile, Massimiliano -- Yan, Jian -- Enge, Martin -- Taipale, Minna -- Aavikko, Mervi -- Katainen, Riku -- Virolainen, Elina -- Bohling, Tom -- Koski, Taru A -- Launonen, Virpi -- Sjoberg, Jari -- Taipale, Jussi -- Vahteristo, Pia -- Aaltonen, Lauri A -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):252-5. doi: 10.1126/science.1208930. Epub 2011 Aug 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868628" target="_blank"〉PubMed〈/a〉
    Keywords: Codon ; Exons ; Female ; Gene Expression Profiling ; Humans ; INDEL Mutation ; Introns ; Leiomyoma/*genetics/metabolism ; Mediator Complex/*genetics ; Mutation ; Mutation, Missense ; Signal Transduction ; Uterine Neoplasms/*genetics/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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