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  • Female  (231)
  • Rats  (224)
  • American Association for the Advancement of Science (AAAS)  (413)
  • Blackwell Publishing Ltd
  • 1975-1979  (413)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (413)
  • Blackwell Publishing Ltd
  • Springer  (10)
Years
Year
  • 1
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    Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for alpha-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, M A -- Yen, R C -- Itkin, P -- Goss, S J -- Seegmiller, J E -- Bakay, B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1016-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218284" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Female ; Genetic Linkage ; Humans ; Hybrid Cells ; Hypoxanthine Phosphoribosyltransferase/genetics ; Phosphotransferases/*genetics ; Ribose-Phosphate Pyrophosphokinase/*genetics ; *Sex Chromosomes ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: In laboratory rodents, concentrations of reduced glutathione (GSH) are exceedingly high (up to 7 to 8 millimolar) in the glandular gastric tissue compared to concentrations in other portions of the gastrointestinal tract or to those of most other organs. Gastric GSH varies diurnally, with the highest levels occurring in the late afternoon or early evening. Starvation, treatment with diethyl maleate, or cold-restraint stress all caused marked decreases in stomach GSH, whereas treatment with cobaltous chloride caused an increase in the GSH concentrations. The physiological significance of the high gastric GSH is unknown, but because this endogenous compound may strongly modulate (decrease or increase) the macromolecular binding of certain chemicals capable of inducing stomach tumors, the possible role of glutathione in the pathogenesis of chemically induced gastric cancer should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Body, S C -- Sasame, H A -- Body, M R -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1010-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Circadian Rhythm ; Cobalt/pharmacology ; Food Deprivation ; Glutathione/*metabolism ; Liver/metabolism ; Rats ; Stomach/*metabolism ; Stomach Neoplasms/*etiology ; Stress, Physiological/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Pituitary-brain vascular relations: a new paradigm (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vascular casts of the pituitary gland have demonstrated a paucity of veins extending from the adenohypophysis to the systemic circulation and have suggested that some adenohypophyseal venous blood returns to the neurohypophysis. The neurohypophyseal capillary bed may function as a vascular switch and in this article a series of 14 questions are proposed regarding the vascular dynamics of the pituitary. Together these questions raise the larger question, namely, whether pituitary hormones are transported directly to the brain to modify brain function?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R M -- Page, R B -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriovenous Anastomosis/anatomy & histology ; Capillaries/anatomy & histology ; Cats ; *Cerebrovascular Circulation ; Dogs ; Humans ; Hypothalamo-Hypophyseal System/blood supply ; Pituitary Gland/*blood supply ; Pituitary Gland, Anterior/blood supply ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Opioid peptides modulate luteinizing hormone secretion during sexual maturation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blank, M S -- Panerai, A E -- Friesen, H G -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endorphins/antagonists & inhibitors/*physiology ; Estradiol/pharmacology ; Female ; Luteinizing Hormone/blood/*secretion ; Male ; Naloxone/antagonists & inhibitors/pharmacology ; Rats ; Secretory Rate/drug effects ; Sexual Maturation/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Ingested mineral fibers: elimination in human urine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Preferential transmission of the Z deficient allele of alpha 1-antitrypsin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapuis-Cellier, C -- Arnaud, P -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313077" target="_blank"〉PubMed〈/a〉
    Keywords: *Alleles ; Child ; Female ; Heterozygote Detection ; Humans ; Male ; *Polymorphism, Genetic ; Sex Factors ; alpha 1-Antitrypsin/genetics ; *alpha 1-Antitrypsin Deficiency
    Print ISSN: 0036-8075
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  • 7
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    Brain stimulation reinforcement: implications of an electrode artifact (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantor, M B -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Electric Stimulation ; Electrodes ; Methods ; Rats ; *Reinforcement (Psychology)
    Print ISSN: 0036-8075
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  • 8
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    The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: The reduction of glycolysis by hypoglycemia or the glucose analog 2-deoxy-D-glucose (2DG) stimulates compensatory sympathetic alterations of metabolism. Considerable attention has been focused on the hypothalamus as the probable locus of requisite metabolic signal detection. We report, however, that unanesthetized chronically decerebrate rats are capable of exhibiting sympathoadrenal hyperglycemia in response to the metabolic challenge presented by 2DG. This findings demonstrates that the forebrain is not necessary for glucoprivic stimulation of this reflex. Since cervical cord transection has been shown to eliminate hyperglycemia induced by 2DG, we conclude that the caudal brainstem contains an essential part of the neural mechanism which both detects metabolic need and ameliorates that need through the release of stored fuels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiRocco, R J -- Grill, H J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1112-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451558" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/physiology ; Afferent Pathways ; Animals ; Blood Glucose/*metabolism ; Brain Stem/*physiology ; Decerebrate State ; Deoxy Sugars/*pharmacology ; Deoxyglucose/*pharmacology ; *Energy Metabolism ; Hypothalamus/*physiology ; Rats ; Reflex/physiology ; Sympathetic Nervous System/physiology
    Print ISSN: 0036-8075
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  • 9
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    Superstitious bar pressing in hippocampal and septal rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Unlike normal animals or those with sham lesions, rats with hippocampal and septal lesions behaved in an operant chamber as if a dependency existed between pellet delivery and their behavior, despite the fact that reinforcement was based on time, not behavior, and was therefore free. This superstitious behavior did not result from a general inability to inhibit responding, as responding rapidly ceased when the pellets were discontinued. These findings suggest that the hippocampus integrates information regarding response-reinforcer relations, which in the normal rat permits superfluous operant behavior to be eliminated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devenport, L D -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):721-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462183" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Conditioning, Operant/physiology ; Hippocampus/*physiology ; Learning/physiology ; Rats ; Reinforcement (Psychology) ; Septal Nuclei/*physiology ; *Superstitions
    Print ISSN: 0036-8075
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  • 10
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    Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dworkin, B R -- Filewich, R J -- Miller, N E -- Craigmyle, N -- Pickering, T G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/drug effects/*physiology ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Hypertension/*physiopathology ; Male ; Motivation/physiology ; Phenylephrine/pharmacology ; Pressoreceptors/*physiology ; Rats
    Print ISSN: 0036-8075
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  • 11
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    Cerebral specialization, writing posture, and motor control of writing in left-handers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: It has been suggested that the inverted hand position of left-handers during writing indicates the left hemisphere of their brain is linguistically specialized and that the writing of these left-handers may be controlled via ipsilateral pathways. Electroencephalograph alpha asymmetry measures at central and parietal leads, as well as dichotic tests, differentiated right-handers from left-handers, but not inverters from noninverters. Electroencephalograph differences between hand posture groups did appear, but only at occipital leads during reading and writing tasks. Regardless of hand posture or speech lateralization, the right central region of the brain is significantly involved in the control of left-handed writing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herron, J -- Galin, D -- Johnstone, J -- Ornstein, R E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1285-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472745" target="_blank"〉PubMed〈/a〉
    Keywords: Auditory Perception/physiology ; Brain/*physiology ; Cognition/physiology ; Female ; *Functional Laterality ; Humans ; Male ; Movement ; *Posture ; Speech/physiology ; Visual Perception/physiology ; *Writing
    Print ISSN: 0036-8075
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  • 12
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    Chromosome 13 long arm interstitial deletion may result from maternal inverted insertion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoegerman, S F -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1035-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472726" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Aberrations/*genetics ; Chromosome Deletion ; Chromosome Disorders ; Chromosome Inversion ; *Chromosomes, Human, 13-15 ; Female ; Humans
    Print ISSN: 0036-8075
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  • 13
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    Vomeronasal and olfactory system modulation of maternal behavior in the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: The onset of maternal responsiveness by virgin female rats to foster pups was observed after (i) complete vomeronasal nerve cuts, (ii) partial olfactory bulb cuts, or (iii) the combined procedures. Although both vomeronasal nerve cuts and olfactory bulb cuts resulted in a more rapid onset of maternal care, relative to control animals with sham operations, animals sustaining the loss of both sources of olfactory input exhibited the shortest response latency. These findings are discussed in terms of the probable distinct functions of the two olfactory systems in the control of maternal behavior in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fleming, A -- Vaccarino, F -- Tambosso, L -- Chee, P -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):372-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760196" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Animals ; Central Nervous System/*physiology ; Female ; *Maternal Behavior ; Olfactory Bulb/physiology ; Olfactory Pathways/*physiology ; Rats ; Smell/*physiology
    Print ISSN: 0036-8075
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  • 14
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    Difference between postpartum and nutritional amenorrhea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- McArthur, J W -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419411" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology/physiopathology ; Body Weight ; Female ; Humans ; Lactation ; Nutrition Disorders/complications ; Pregnancy ; Time Factors
    Print ISSN: 0036-8075
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  • 15
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    Digitalis genin activity: side-group carbonyl oxygen position is a major determinant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: The Na+,k+-adenosine triphosphatase-inhibiting activity of digitalis genins and their analogs is a function of side-group carbonyl (C = O) oxygen position. For each 2.2 angstroms that this oxygen is displaced from its position in digitoxigenin, activity drops by one order of magnitude. This quantitative relation resolves previously proposed models which have attempted to describe the molecular basis of genin activity. A multidisciplinary (crystallographic, conformational energy, synthetic, biological) approach to structure-activity relations is described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fullerton, D S -- Yoshioka, K -- Rohrer, D C -- From, A H -- Ahmed, K -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):917-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/enzymology ; Digitalis Glycosides/*pharmacology ; Molecular Conformation ; Rats ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors ; Structure-Activity Relationship
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  • 16
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    Development of the capacity for tactile information transfer between hemispheres in normal children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The hypothesis of less direct interaction between hemispheres in young children was supported by a behavioral test. Fabric samples were compared with either the same hand (same hemisphere) or with opposite hands (between hemispheres). Crossed errors were a significantly larger proportion of total errors in 3-year-olds than in 5-year-olds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galin, D -- Johnstone, J -- Nakell, L -- Herron, J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451542" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*growth & development/physiology ; Child, Preschool ; Female ; *Functional Laterality ; Humans ; Touch/*physiology
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  • 17
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    Induction of copulatory behavior in sexually inactive rats by naloxine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gessa, G L -- Paglietti, E -- Quarantotti, B P -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):203-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432642" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation/*drug effects ; Endorphins/*pharmacology ; Enkephalins/*pharmacology ; Feeding Behavior/drug effects ; Male ; Motor Activity/drug effects ; Naloxone/*pharmacology ; Rats
    Print ISSN: 0036-8075
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  • 18
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    Electroencephalogram correlates of higher cortical functions (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: By means of two-stage, nonlinear multivariate pattern recognition, electroencephalograms (EEG's) were analyzed during performance of verbal and spatial tasks. Complex scalp distributions of theta-, beta-, and, to a lesser extent, alpha-band spectral intensities discriminated between the two members of a pair of tasks, such as writing sentences and Koh's block design. Small EEG asymmetries were probably attributable to limb movements and other uncontrolled noncognitive aspects of tasks. Significant EEG differences beteeen cognitive tasks were eliminated when controls for inter-task differences in efferent activity, stimulus characteristics, and performance-related factors were introduced. Each controlled task was associated with an approximately 10 percent reduction, as compared with visual fixation, in the magnitude of alpha- and beta-band spectral intensity. This effect occurred bilaterally and was approximately the same over occipital, parietal, and central regions, with some minor difference over the frontal region in the beta band. With these controls, no evidence for lateralization of different cognitive functions was found in the EEG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gevins, A S -- Zeitlin, G M -- Doyle, J C -- Yingling, C D -- Schaffer, R E -- Callaway, E -- Yeager, C L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):665-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760212" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cerebral Cortex/*physiology ; Cognition/*physiology ; *Electroencephalography ; Female ; *Functional Laterality ; Humans ; Male ; Memory/physiology ; Movement ; Pattern Recognition, Visual/physiology
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
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    Vitamin D deficiency and reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-06
    Description: Female weanling rats from a colony maintained on a diet low in vitamin D were raised on a diet that was deficient in vitamin D but was otherwise adequate. Vitamin D deficiency was confirmed in the rats by hypocalcemia and the absence of vitamin D metabolites in blood. These females gave birth to litters that were slightly smaller than control litters from females maintained on a vitamin D-containing diet. The pups from the vitamin D-deficient mothers appeared normal throughout lactation, and at weaning had normal concentrations of calcium and phosphate in the plasma. These results indicate that vitamin D and its metabolites are not necessary for reproduction and fetal development in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halloran, B P -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):73-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling/blood ; Body Weight ; Bone Development ; Calcium/blood ; Female ; Hydroxycholecalciferols/blood ; Phosphates/blood ; Rats ; *Reproduction ; Vitamin D Deficiency/blood/*physiopathology
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  • 21
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    Cerebral norepinephrine: influence on cortical oxidative metabolism in situ (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Unilateral lesion of the locus coeruleus and the resultant norepinephrine depletion in the ipsilateral cerebrum alters the relationship between cerebral metabolic demands and local delivery of oxygen and substrates. This effect of norepinephrine depletion is demonstrated by slower recovery of the redox ratio of cytochrome a,a3 during increased metabolic demands induced by local cortical stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harik, S I -- LaManna, J C -- Light, A I -- Rosenthal, M -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*metabolism ; Cytochromes/*metabolism ; Energy Metabolism ; Evoked Potentials ; Locus Coeruleus/*physiology ; Male ; Norepinephrine/*physiology ; Oxidation-Reduction ; Rats ; Spectrophotometry
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  • 22
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    Emergence of interoceptive and exteroceptive control of behavior in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-31
    Description: The role of exteroceptive and interoceptive aversive stimuli in rats 2 to 14 days old was investigated according to an odor aversion paradigm. Amyl acetate odor was paired with eigher peripheral shock, intraperitoneal shock, or lithium chloride poisoning. Intraperitoneal shock was an effective unconditioned stimulus at all ages and produced odor aversions comparable to lithium chloride poisoning; peripheral shock, however, was effective only in rats 10 days of age or older. Interoceptive control of aversively motivated behaviors thus seems to develop before exteroceptive control, and the failure of previous studies to find reliable learning and retention of shock-motivated behaviors before 8 to 10 days of age may be attributable to the site to which shock was applied rather than to insensitivity to shock per se.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haroutunian, V -- Campbell, B A -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):927-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472715" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Avoidance Learning/*physiology ; Behavior, Animal/*physiology ; Conditioning (Psychology)/physiology ; Electroshock ; Perception/*physiology ; Rats ; Retention (Psychology)/physiology ; Smell/physiology
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  • 23
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    Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Papillary fibroblasts, when compared to reticular fibroblasts from the same skin specimen, exhibit greater proliferative capacities in vitro. These results demonstrate a difference in function between morphologically similar cells obtained from the same tissue. Such findings represent an important consideration in the study of cell aging in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Grove, G -- New York, N.Y. -- Science. 1979 May 4;204(4392):526-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Female ; Fibroblasts/cytology ; Humans ; Male ; Skin/*cytology
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
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  • 25
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    Ketone bodies are selectively used by individual brain regions (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-20
    Description: Close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. Furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. The results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkins, R A -- Biebuyck, J F -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier ; Brain/*metabolism ; Glucose/metabolism ; Hydroxybutyrates/metabolism ; Ketone Bodies/*metabolism ; Male ; Rats ; Starvation/metabolism
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    Smallpox death in Britain challenges presumption of laboratory safety (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkes, N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):855-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419409" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Great Britain ; Humans ; Jurisprudence ; Laboratories/*standards ; Peer Review ; Safety ; Smallpox/*etiology ; World Health Organization
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  • 27
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    Cancer and environment: Higginson speaks out (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higginson, J -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1363-4, 1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472753" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; *Carcinogens ; Diet ; *Environment ; Female ; Humans ; Life Style ; Male ; Neoplasms/*etiology ; Stress, Psychological/complications
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  • 28
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    Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: 17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochberg, R B -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1138-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*analogs & derivatives/analysis/metabolism ; Female ; Iodine Radioisotopes ; Radioimmunoassay/methods ; Rats ; Receptors, Estrogen/*metabolism ; Uterus/metabolism
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  • 29
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    Norepinephrine inhibits calcium-dependent potentials in rat sympathetic neurons (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-15
    Description: Norepinephrine reversibly antagonizes three calcium-dependent potentials recorded from rat postganglionic neurons. Norepinephrine inhibits the development of a shoulder on the aciton potential, the magnitude of the hyperpolarizing afterpotential, and the rate of rise and amplitude of the calcium spike. The action of norepinephrine is antagonized by the alpha-adrenergic antagonist phentolamine, but not by MJ 1999, a beta-adrenergic antagonist. These results suggest that activation of an alpha-adrenergic receptor may antagonize a voltage-sensitive calcium current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horn, J P -- McAfee, D A -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/antagonists & inhibitors/*physiology ; Dopamine/pharmacology ; Electric Conductivity ; Ganglia, Autonomic/*drug effects ; In Vitro Techniques ; Ion Channels/*drug effects ; Isoproterenol/pharmacology ; Membrane Potentials/*drug effects ; Neurons/drug effects ; Norepinephrine/*pharmacology ; Rats ; Receptors, Adrenergic, alpha/drug effects
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  • 30
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    Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosobuchi, Y -- Rossier, J -- Bloom, F E -- Guillemin, R -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83674" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*physiology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid/immunology ; Enkephalins/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Radioimmunoassay
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    Mammary cancer: selective action of the estrogen receptor complex (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ip, M -- Milholland, R J -- Rosen, F -- Kim, U -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Cytosol/metabolism ; Estradiol/metabolism/pharmacology ; Female ; Male ; Mammary Neoplasms, Experimental/*metabolism ; Rats ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/biosynthesis/drug effects/*metabolism
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    Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-26
    Description: A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical gamma-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnston, M V -- Grzanna, R -- Coyle, J T -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/32620" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/cytology/*embryology ; Animals ; Azo Compounds/*pharmacology ; Brain/cytology/*embryology ; Cell Differentiation/drug effects ; Cerebral Cortex/embryology/enzymology ; Glutamate Decarboxylase/metabolism ; Methylazoxymethanol Acetate/*pharmacology ; Neural Pathways/embryology ; Norepinephrine/metabolism ; Rats ; Tyrosine 3-Monooxygenase/metabolism ; gamma-Aminobutyric Acid/metabolism
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    DNA polymerase with characteristics of reverse transcriptase purified from human milk (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-04
    Description: A DNA polymerase purified from a particulate fraction of human milk has biochemical and biophysical properties similar to those of viral reverse transcriptases. This enzyme is immunologically distinct from cellular DNA polymerases obtained from a variety of human sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kantor, J A -- Lee, Y H -- Chirikjian, J G -- Feller, W F -- New York, N.Y. -- Science. 1979 May 4;204(4392):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86209" target="_blank"〉PubMed〈/a〉
    Keywords: DNA-Directed DNA Polymerase/immunology/*metabolism ; Female ; Humans ; Milk, Human/*enzymology ; Molecular Weight ; RNA-Directed DNA Polymerase/immunology/*metabolism ; Retroviridae/enzymology ; Substrate Specificity ; Templates, Genetic
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  • 34
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    Erythrosin B inhibition of neurotransmitter accumulation by rat brain homogenate (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: A mixture of seven food dyes inhibited the accumulation of eight neurotransmitters or neurotransmitter precursors by rat brain homogenate. At a low concentration (1 microgram per milliliter), erythrosin B (FD&C red 3) was the only dye that inhibited dopamine accumulation. Erythrosin also was effective in decreasing the accumulation of all the other transmitter substances, suggesting that the inhibition is nonspecific and probably secondary to general membrane alteration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logan, W J -- Swanson, J M -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):363-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39341" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell-Free System ; Depression, Chemical ; Dopamine/metabolism ; Erythrosine/adverse effects/*pharmacology ; Fluoresceins/*pharmacology ; Food Coloring Agents/adverse effects/*pharmacology ; Neurotransmitter Agents/*metabolism ; Rats ; Synapses/*drug effects
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    3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: A direct method has been employed to estimate the rate of production by human brain of 3-methoxy-4-hydroxyphenethyleneglycol, the major metabolite of brain norepinephrine, a brain neurotransmitter. Venous specimens were obtained from the internal jugular vein from ten awake human subjects at a puncture site above the common facial vein, the first major source of extracranial inflow. Arterial specimens were simultaneously obtained from the radial artery. Plasma samples were assayed and a highly significant difference was found in the concentration of the metabolite in plasma coming out of the brain (venous blood) as compared to plasma entering the brain (arterial blood). This venous-arterial difference was calculated to be 0.7 +/- 0.1 nanogram per milliliter of blood. Assuming an adult brain weight of 1400 grams and normal cerebral blood flow, it is estimated that the rate of production of 3-methoxy-4-hydroxyphenethyleneglycol by the awake human brain is approximately 597 nanograms per minute or 35.8 micrograms per hour. Urine specimens were also collected from six of these subjects during a period of 1 to 3.5 hours, which bracketed the time the blood samples were obtained. For these six subjects the output of 3-methyoxy-4-hydroxyphenethyleneglycol by whole brain was estimated to be 40.9 micrograms per hour, whereas the rate of its excretion into urine was 64.5 micrograms per hour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maas, J W -- Hattox, S E -- Greene, N M -- Landis, D H -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472724" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*metabolism ; Cerebrovascular Circulation ; Female ; Glycols/*metabolism ; Humans ; Male ; Methoxyhydroxyphenylglycol/blood/*metabolism/urine ; Middle Aged ; Norepinephrine/metabolism
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    Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luzzatto, L -- Usanga, E A -- Bienzle, U -- Esan, G F -- Fusuan, F A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1418-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472761" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Genetic Linkage ; Glucosephosphate Dehydrogenase/blood/genetics ; *Hematopoiesis ; Heterozygote ; Humans ; Leukocytes/enzymology ; *Mosaicism ; *Sex Chromosomes ; *X Chromosome
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    Hippocampal afterdischarges: differential spread of activity shown by the [14C]deoxyglucose technique (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: Differential spread of afterdischarge activity initiated electrically in ventral and dorsal parts of the hippocampal formation was studied by the [14C]deoxyglucose technique in rats. Afterdischarges initiated in either the ventral or dorsal hippocampal formation, without activation of the ventral subicular cortex, increased glucose utilization in the lateral septum. In contrast, afterdischarges initiated by direct activation of the ventral subicular cortex increased glucose utilization in extensive areas of the ipsilateral amygdala, claustrum, hypothalamus, preoptic region, and basal forebrain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kliot, M -- Poletti, C E -- New York, N.Y. -- Science. 1979 May 11;204(4393):641-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432672" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain/*metabolism ; Brain Mapping ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Diencephalon/metabolism ; Electric Stimulation ; Epilepsy/physiopathology ; Hippocampus/*physiology ; Male ; Neural Pathways/physiology ; Rats
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  • 38
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    Intercellular communication in pancreatic islet monolayer cultures: a microfluorometric study (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Single islet cells in monolayer cultures of neonatal rat pancreas were microinjected with fluorescein and scanned topographically by microfluorometry. Fluorescein spread from an injected islet cell directly into neighboring islet cells, and, in the presence of 16.7 millimolar glucose, significantly more islet cells communicated with the injected cell than in glucose-free medium. Islet cells were also microinjected with glycolytic substrates and activators that produced transient changes in cellular levels of reduced pyridine nucleotides-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate [NAD(P)H]. Changes in NAD(P)H fluorescence were observed in islet cells incubated first for 18 hours in very low glucose concentrations and then in a glucose-free medium and injected with glycolytic substrates and activators; however, little change of fluorescence occurred in adjacent islet cells. In contrast, after adding 16.7 millimolar glucose to the medium, injection of glycolytic substrates and activators produced transient changes in NAD(P)H fluorescence in the injected cell and in neighboring cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohen, E -- Kohen, C -- Thorell, B -- Mintz, D H -- Rabinovitch, A -- New York, N.Y. -- Science. 1979 May 25;204(4395):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Communication/drug effects ; Fluoresceins ; Glucose/pharmacology ; Glycolysis ; Islets of Langerhans/cytology/*physiology ; Kinetics ; NAD/metabolism ; NADP/metabolism ; Rats ; Spectrometry, Fluorescence
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  • 39
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    Treatment reduces deaths from hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1386-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505012" target="_blank"〉PubMed〈/a〉
    Keywords: Antihypertensive Agents/therapeutic use ; Blood Pressure ; Diet, Sodium-Restricted ; Female ; Humans ; Hypertension/complications/*drug therapy/physiopathology ; Male ; Myocardial Infarction/etiology/prevention & control
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  • 40
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    Sex hormones and brain development (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112680" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocortical Hyperfunction/physiopathology ; Animals ; Behavior/*physiology ; Behavior, Animal/physiology ; Brain/*growth & development ; Female ; Gonadal Steroid Hormones/*physiology ; Haplorhini ; Humans ; Male ; Preoptic Area/growth & development ; Rats ; Receptors, Estrogen/metabolism ; Sex Differentiation ; Testosterone/metabolism
    Print ISSN: 0036-8075
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  • 41
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    Scientists attack report that obstetrical medications endanger children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87012" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/*adverse effects ; Child ; Child Development/*drug effects ; Child, Preschool ; Delivery, Obstetric/methods ; Developmental Disabilities/chemically induced ; Female ; Humans ; Infant ; Infant, Newborn ; Labor, Obstetric ; Methods ; Pregnancy
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  • 42
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
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  • 43
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    Moment of inertia: psychophysical study of an overlooked sensation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The distribution of mass in an object held in the hand, as described by its moment of inertia, is a fundamental and potent but largely unrecognized contributor to the object's "feel." A limited set of experiments has produced Weber fractions for human differential sensitivity to this property in the approximate range of 1/5 to 1/3, which is about ten times the Weber fraction reported for lifted weights.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kreifeldt, J G -- Chuang, M C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):588-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493965" target="_blank"〉PubMed〈/a〉
    Keywords: Biophysical Phenomena ; *Biophysics ; Female ; Humans ; Male ; Weight Perception/*physiology
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  • 44
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    Movement disorders of aged rats: reversal by dopamine receptor stimulation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments in swimming. Compared with young adult rats (3 to 4 months old), the older animals moved their limbs less vigorously and were less successful in keeping their heads above water. The young, but not old, rats maintained a position nearly horizontal to the water surface and planed across it. These movement dysfunctions of aged rats resemble those seen in young adult animals that have sustained injury to brain dopamine-containing neurons. The swimming impairments of the aged rats were reversed by the dopamine receptor stimulant apomorphine and by the biosynthetic precursor of dopamine, L-dopa. Thus, age-related alterations in brain dopaminergic systems may be responsible for some of the movement disturbances associated with senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, J F -- Berrios, N -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):477-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504992" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Apomorphine/therapeutic use ; Levodopa/therapeutic use ; Male ; Movement Disorders/drug therapy/*physiopathology ; Rats ; Receptors, Dopamine/*physiology ; Swimming ; Time Factors
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  • 45
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    The annual Pap smear: an idea whose time has gone? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451586" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Mass Screening/*economics ; Middle Aged ; *Papanicolaou Test ; Risk ; Socioeconomic Factors ; Uterine Cervical Neoplasms/epidemiology/*prevention & control ; Vaginal Smears/*economics
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  • 46
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    The HDL: the good cholestrol carriers? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/223241" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Cholesterol/*blood/metabolism ; Diet ; Female ; Humans ; Lipoproteins, HDL/*blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Risk ; Running ; Sex Factors ; Tissue Distribution
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  • 47
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    Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers. These abnormalities probably result from the ability of Clomid to cause long-term estrogenic stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormack, S -- Clark, J H -- New York, N.Y. -- Science. 1979 May 11;204(4393):629-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432668" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Clomiphene/*toxicity ; Fallopian Tubes/pathology ; Female ; Metaplasia ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Uterine Diseases/chemically induced/pathology ; Vaginal Diseases/chemically induced
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  • 48
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    Drug safety: phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):144, 146, 148.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451584" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; Liver Neoplasms/*chemically induced ; Mice ; Neoplasms, Experimental/chemically induced ; Phenacetin/*adverse effects/standards ; Rats
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    Insulin receptor binding in obesity: a reassessment (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo--as it does in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Misbin, R I -- O'Leary, J P -- Pulkkinen, A -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1003-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472718" target="_blank"〉PubMed〈/a〉
    Keywords: Dietary Carbohydrates/metabolism ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Male ; Monocytes/metabolism ; Obesity/*metabolism ; Physical Exertion ; Receptor, Insulin/*metabolism
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    Nitrite promotes lymphoma incidence in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-08
    Description: Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newberne, P M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Lymphocytes/drug effects ; Lymphoma/*chemically induced ; Neoplasms, Experimental/chemically induced ; *Nitrites/pharmacology ; Rats
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    Endogenous inhibitor of colchicine-tubulin binding in rat brain (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-10
    Description: A competitive inhibitor of colchicine binding to tubulin has been found in rat brain. Most of the inhibitor is associated with microsomes but some inhibitor, with an apparent molecular weight of approximately 250,000, is found in the cytosol. Both the microsomal and cytosol inhibitors are heat- and trypsin-sensitive, indicating that a protein moiety is required for activity. The microsomes bind tubulin directly; the microsomal and cytosol fractions both inhibit microtubule assembly in vitro. The inhibitor may function in the living cell to bind and sequester non-polymerized tubulin. Regulation of tubulin attachment to microsomes could then control the concentration of cytosolic tubulin available for microtubule assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherline, P -- Schiavone, K -- Brocato, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):593-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451622" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Colchicine/*metabolism ; Cytosol/physiology ; Glycoproteins/*metabolism ; Kinetics ; Microsomes/metabolism ; Microtubules/ultrastructure ; Nerve Tissue Proteins/*physiology ; Protein Binding/drug effects ; Rats ; Tubulin/*metabolism
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  • 52
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    Drug discrimination training with progressively lowered doses (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-17
    Description: Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Overton, D A -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):720-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlordiazepoxide/pharmacology ; Cyclazocine/pharmacology ; Discrimination Learning/*physiology ; Dose-Response Relationship, Drug ; Fentanyl/pharmacology ; *Pharmacology ; Phenobarbital/pharmacology ; Rats ; Scopolamine Hydrobromide/pharmacology
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  • 53
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    Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-29
    Description: The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, J W -- Parker, J B -- Haussler, M R -- Boass, A -- Toverud, S V -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451573" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/blood ; Dihydroxycholecalciferols/*blood ; Female ; Hydroxycholecalciferols/*blood ; *Lactation ; Parathyroid Glands/physiology ; Parathyroid Hormone/physiology ; Phosphorus/blood ; Pregnancy ; *Pregnancy, Animal ; Rats
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    Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: After mature rats that had been fed on a vitamin D3-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D3, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, and colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hairshafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D3 or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D3 metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stumpf, W E -- Sar, M -- Reid, F A -- Tanaka, Y -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Digestive System/*metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Intestinal Mucosa/metabolism ; Kidney/*metabolism ; Male ; Parathyroid Glands/*metabolism ; Pituitary Gland/*metabolism ; Rats ; Skin/*metabolism ; Stomach/metabolism
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    Microwave radiation and chlordiazepoxide: synergistic effects on fixed-interval behavior (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
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    Nickel carbonyl: prenatal exposure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
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    Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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    Distribution of nitrogen-13 from labeled nitrate (13No3-) in humans and rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: The body distribution of gavaged or intravenously administered nitrate labeled with nitrogen-13 was studied in humans and rats with the following results: (i) the labeled compound is not quickly absorbed from the stomach; (ii) the concentration of the label increases inside the lower intestinal tract (cercum and large intestine) when ingested or intravenously injected; and (iii) humans and rats have the capacity to store a portion of the label in their bodies. These observation indicate that depletion of body stores, the passage of nitrate down the gut, or the secretion of nitrate into the intestinal lumen may be a better explanation of the urinary, ileal, and fecal concentrations of nitrate and nitrite recently measured in humans that a bacterial nitrification reaction in the intestines, as suggested by Tannenbbaum et al.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Witter, J P -- Gatley, S J -- Balish, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441728" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestines/metabolism ; Nitrates/blood/*metabolism ; Nitrites/metabolism ; *Nitrogen Radioisotopes ; Rats ; Tissue Distribution
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    Lead enhancement of lithium-induced polydipsia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wedeen, R P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):725-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drinking Behavior/*drug effects ; Lead Poisoning/*physiopathology ; Lithium/*pharmacology ; Rats ; Water-Electrolyte Balance/drug effects
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    4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, H L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):696-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462176" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminobutyrate Transaminase/*blood ; Animals ; Blood Platelets/*enzymology ; Brain/enzymology ; Dogs ; Enzyme Activation/drug effects ; Humans ; Kinetics ; Pyridoxal Phosphate/pharmacology ; Rats ; Substrate Specificity ; Transaminases/*blood ; gamma-Aminobutyric Acid/blood
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    Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- Farb, D H -- Leeman, S E -- Jessell, T M -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):481-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capsaicin/*pharmacology ; Fatty Acids, Unsaturated/*pharmacology ; Hot Temperature ; Injections, Spinal ; Movement/drug effects ; Nociceptors/drug effects ; Pain/*physiopathology ; Rats ; Spinal Cord/*metabolism ; Substance P/administration & dosage/*metabolism ; Synaptic Transmission/drug effects
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    Sucrose consumption early in life fails to modify the appetite of adult rats for sweet foods (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: Male rats consumed a diet containing 0, 12, or 48 percent sucrose on days 16 to 30 of life. Thereafter, they had simultaneous access to all three diets until day 63. No relationship was detected between sucrose consumption early in life and subsequent preference for sucrose. The onset of puberty was associated with a decreased appetite for sucrose among animals of both sexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wurtman, J J -- Wurtman, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Dietary Carbohydrates ; Food Preferences/*drug effects ; Male ; Rats ; Saccharin ; Sexual Maturation ; Sucrose/*pharmacology ; Taste
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    Treatment of mental disorders (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, S N -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):834.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents ; Brain Chemistry/*drug effects ; Choline/pharmacology ; Rats ; Tryptophan/*pharmacology
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    Phase advance of the circadian sleep-wake cycle as an antidepressant (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-09
    Description: Sleep in depressed patients resembles sleep in normal subjects whose circadian rhythms of temperature and rapid-eye-movement sleep are phase-advanced (shifted earlier) relative to their sleep schedules. If this analogy is relevant to the pathophysiology of depressive illness, advancing the time of sleep and awakening should temporarily compensate for the abnormal timing of depressed patients' circadian rhythms. Four of seven manic-depressive patients studied longitudinally spontaneously advanced their times of awakening (activity onset) as they emerged from the depressive phase of their illness. In a phase-shift experiment, a depressed manic-depressive woman was twice brought out of depression for 2 weeks by advancing her sleep period so that she went to sleep and arose 6 hours earlier than usual. The antidepressant effect of the procedure was temporary and similar in duration to circadian desynchronization induced by jet lag in healthy subjects. This result supports the hypothesis that abnormalities of sleep patterns in some types of depression are due to abnormal internal phase relationships of circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehr, T A -- Wirz-Justice, A -- Goodwin, F K -- Duncan, W -- Gillin, J C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):710-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227056" target="_blank"〉PubMed〈/a〉
    Keywords: Bipolar Disorder/*physiopathology/therapy ; Body Temperature Regulation ; *Circadian Rhythm ; Female ; Humans ; Middle Aged ; Motor Activity/physiology ; Sleep, REM/*physiology
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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    Intraventricular carbachol mimics the effects of light on the circadian rhythm in the rat pineal gland (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-26
    Description: Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zatz, M -- Brownstein, M J -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/32619" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/metabolism ; Animals ; Biological Clocks/drug effects ; Carbachol/administration & dosage/*pharmacology ; Circadian Rhythm/*drug effects/radiation effects ; Injections, Intraventricular ; *Light ; Male ; Neurotransmitter Agents/pharmacology ; Pineal Gland/enzymology/*physiology ; Rats ; Serotonin
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    Surgeon general seeks physicians' help in DES alert (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Jan 12;203(4376):159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758685" target="_blank"〉PubMed〈/a〉
    Keywords: Diethylstilbestrol/*adverse effects ; Drug Information Services ; Female ; Government Agencies ; Humans ; Mesonephroma/*chemically induced ; United States ; Vaginal Neoplasms/*chemically induced
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    Chemical carcinogens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 16;203(4381):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens/administration & dosage ; Dose-Response Relationship, Drug ; Mice ; Mutagens ; Neoplasms, Experimental/chemically induced ; Rats ; Vinyl Chloride/*toxicity ; Vinyl Compounds/*toxicity
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    Effects of anesthesia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 23;203(4382):705.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419403" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Drug-Induced ; Abortion, Spontaneous/*chemically induced ; Anesthetics/*adverse effects ; Female ; Humans ; Male ; Pregnancy
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    Delayed neurotoxicity of phenylphosphonothioate esters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
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  • 72
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    Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casper, R F -- Yen, S S -- Wilkes, M M -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):823-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462193" target="_blank"〉PubMed〈/a〉
    Keywords: *Climacteric ; Dopamine/blood ; Epinephrine/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/blood/*secretion ; Middle Aged ; Norepinephrine/blood ; Prolactin/blood
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  • 73
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    Prolonged inhibition of neurons by neuroendocrine cells in Aplysia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: In the abdominal ganglion of Aplysia, a burst of action potentials in peptide-secreting neuroendocrine cells, the bag cells, produces slow inhibition of two identified bursting pacemaker neurons. The inhibition is due to slow hyperpolarizing potential that reduces bursting pacemaker activity for 3 hours or more. The slow inhibitory potential results from a large and prolonged increase in membrane conductance to potassium ions as well as a slower ionic process that is relatively independent of membrane conductance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, P -- Mayeri, E -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):417-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35827" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Aplysia/*physiology ; Electric Conductivity ; Electric Stimulation ; Female ; Ganglia/physiology ; *Neural Inhibition ; Neurosecretory Systems/*physiology ; Neurotransmitter Agents/physiology ; Oviposition ; Peptides/physiology
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  • 74
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    2-Deoxy-D-glucose maps movement-specific nervous activity in the second visual ganglion of Drosophila (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Adult Drosophila were fed with tritium labeled deoxyglucose prior to a 5-hour period of visual stimulation. A flickering disk of light and a moving grating were presented to the left and right eyes, respectively. Autoradiography revealed enhanced labeling solely in that part of the second optic ganglion (medulla) whose visual field was stimulated by movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchner, E -- Buchner, S -- Hengstenberg, R -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):687-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Drosophila melanogaster/anatomy & histology/*physiology ; Female ; Ganglia/metabolism ; Motion Perception/*physiology ; Neurons/*metabolism ; Visual Pathways/metabolism ; Visual Perception/physiology
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  • 75
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    Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, T K -- Lester, G E -- Lorenc, R S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dihydroxycholecalciferols/biosynthesis ; Female ; Fetal Blood/metabolism ; Hydroxycholecalciferols/*metabolism ; Hydroxylation ; Kidney/embryology/metabolism ; *Nephrectomy ; Placenta/metabolism ; Pregnancy ; *Pregnancy, Animal
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    Opiate antagonists: a role in the treatment of hypovolemic shock (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: The opiate antagonist naloxone has been used to treat shock following acute blood loss in conscious rats. Naloxone treatment rapidly increased mean arterial pressure and pulse pressure in this new shock model. More importantly, these blood pressure changes were sustained and survival was significantly increased with maloxone as compared with placebo treatment. From these findings, it may be inferred that endorphins may play a role in the pathophysiology of hypovolemic shock. It is suggested that narcotic antagonists may prove to be of therapeutic value in the treatment of shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faden, A I -- Holaday, J W -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):317-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure ; Hypotension/drug therapy ; Male ; Naloxone/*therapeutic use ; Rats ; Shock/*drug therapy/physiopathology
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  • 77
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    [Interpreting "imitative" responses in early infancy] (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobson, S W -- Kagan, J -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451595" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/*physiology ; Female ; Humans ; *Infant ; *Infant, Newborn ; Male ; Movement ; Tongue/physiology
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  • 78
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    Nanosecond X-ray diffraction from biological samples with a laser-produced plasma source (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: By using 4.45-angstrom radiation generated by Cl+15 ions in a laser plasma and nanosecond exposures, low-angle x-ray diffraction patterns were obtained from dried rat spinal nerves and a powder of cholesterol. Three to four 400-picosecond, 45-joule pulses were required for the exposure. This new technique should have wide application in structural kinetic studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, R D -- Forsyth, J M -- New York, N.Y. -- Science. 1979 May 11;204(4393):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432665" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cholesterol ; In Vitro Techniques ; *Lasers ; Neurons/*ultrastructure ; Rats ; Time Factors ; X-Ray Diffraction/*methods
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  • 79
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    Calcitonin: inhibitory effect on eating in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
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  • 80
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    Holographic assessment of a hypothesized microwave hearing mechanism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Exposure of the head to pulse-modulated microwaves induces the perception of a sound. It has been hypothesized that the electromagnetic energy is converted to acoustic energy in the skull and then conducted through the bone. Dynamic time-averaged interferometric holography showed that the predicted motion of head tissue did not occur. An alternative locus for this hearing effect is suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, A H -- Coren, E -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):232-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482939" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Bone and Bones/radiation effects ; Cochlea/physiology/radiation effects ; Guinea Pigs ; Hearing/*physiology ; Holography ; Humans ; *Microwaves ; Models, Biological ; Motion ; Rats ; Vibration
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  • 81
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    Pseudohermaphroditism in Ilyanassa obsoleta (Mollusca: Neogastropoda) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Field studies, a rearing and maintenance program, and a transfer experiment have shown that anomalous male traits found in some female Ilyanassa obsoleta are an expression of environmentally controlled psuedohermaphroditism. The particular pattern of pseudohermaphroditism discovered in this species has not been reported previously from any other group, but may be characteristic of the Neogastropoda.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenner, M G -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/pathology/*physiopathology ; Female ; Male ; Sex Differentiation ; Snails/growth & development/*physiology
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  • 82
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    Shark heart mitochondria: effects of external osmolality on respiration (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewiston, N -- Newman, A -- Robin, E -- Holtzman, D -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):75-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482928" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Animals ; Mitochondria, Heart/*metabolism ; Mitochondria, Liver/metabolism ; *Osmolar Concentration ; *Oxygen Consumption ; Rats ; Sharks/*metabolism ; Species Specificity
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  • 83
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    Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Like, A A -- Rossini, A A -- Guberski, D L -- Appel, M C -- Williams, R M -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/388619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/*therapeutic use ; *Autoimmune Diseases ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/*immunology/prevention & control/therapy ; Immunosuppression ; Islets of Langerhans/immunology ; Isoantibodies ; Lymphocytes/*immunology ; Rats
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  • 84
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    Genetic resistance to aflatoxin in Japanese quail (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Progress was rapid in attempts to develop lines of quail resistant to acute aflatoxicosis induced by oral dosing with aflatoxin. After five generations of selection, 8- and 11-fold differences were present in mortality between two selected lines and their respective control lines. These quail lines should be of value in investigating the physiological basis of resistance to aflatoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marks, H L -- Wyatt, R D -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515737" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxins/*pharmacology ; Animals ; Coturnix/*genetics ; *Drug Resistance ; Female ; Genes ; Male ; Quail/*genetics ; Selection, Genetic
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  • 85
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    Development of the rat's uncrossed retinotectal pathway and its relation to plasticity studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: In the normal newborn rat the retinotectal pathway from each eye distributes across the whole area of both the ipsilateral and contralateral superior colliculus. Most of the ipsilateral projection retracts during the first ten postnatal days to produce the normal adult pattern, but retraction fails to occur if one eye is removed at birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Land, P W -- Lund, R D -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):698-700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462177" target="_blank"〉PubMed〈/a〉
    Keywords: Albinism/physiopathology ; Animals ; Animals, Newborn/growth & development ; Functional Laterality ; Optic Chiasm/growth & development ; Rats ; Retina/*growth & development ; Superior Colliculi/cytology/*growth & development ; Visual Pathways/*growth & development
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  • 86
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    On the specificity of kainic acid (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-22
    Description: The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus. Extensive neuronal loss and gliosis were observed around the injection site. In addition, a significant and consistent 25 percent depletion of hippocampal-cortical noradrenaline was also obtained. The results suggest that although kainic acid has its greatest destructive action on neuronal perikarya, a significant amount of damage to axons of passage may also occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451544" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*drug effects ; Animals ; Brain/metabolism ; Brain Stem/cytology/drug effects ; Cerebral Cortex/drug effects ; Hippocampus/drug effects ; Hydroxydopamines/pharmacology ; Kainic Acid/*pharmacology ; Locus Coeruleus/drug effects ; Male ; Neurons/*drug effects/ultrastructure ; Norepinephrine/metabolism ; Pyrrolidines/*pharmacology ; Rats
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  • 87
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    Dysmenorrhea: basic research leads to a rational therapy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):175-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109921" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclooxygenase Inhibitors ; Dysmenorrhea/drug therapy/*physiopathology ; Female ; Humans ; Progesterone/physiology ; Prostaglandins/*physiology ; Uterine Contraction
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  • 88
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    Subfornical organ efferents to neural systems for control of body water (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: The subfornical organ, a circumventricular structure of the central nervous system, has efferent neural projections to sites within the brain known to be involved in drinking behavior and secretion of antidiuretic hormone. By using anterograde tracing techniques, it is shown that the subfornical organ projects to the nucleus medians of the medial preoptic area, to the organum vasculosum of the lamina terminalis, and to the supraoptic nuclei bilaterally. Its efferent connectivity is confirmed by retrograde transport of horseradish peroxidase. The organum vasculosum of the lamina terminalis, another circumventricular organ and a suspected receptor site for angiotensin II, is involved in the circuitry of the subfornical organ and also has an efferent projection to the supraoptic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miselis, R R -- Shapiro, R E -- Hand, P J -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cerebral Ventricles/*cytology ; Drinking Behavior/physiology ; Efferent Pathways/physiology ; Male ; Neurosecretory Systems/*physiology ; Preoptic Area/cytology ; Rats ; Subfornical Organ/cytology/*physiology ; Supraoptic Nucleus/cytology ; *Water-Electrolyte Balance
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  • 89
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    Noradrenergic innervation of cerebral cortex: widespread effects of local cortical lesions (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: The trajectory of the intracortical noradrenergic fibers has been characterized by histochemical analysis following the production of cortical lesions in the rate. A large group of noradrenergic fibers enters the cortex at the frontal pole and proceeds caudally through the deep layers of dorsolateral cortex. Branches arise from these longitudinally directed fibers and form a uniform pattern of innervation throughout lateral cortex. Because these fibers travel long distances rostrocaudally within the gray matter, a large area of cortex can be deprived of noradrenergic innervation by a relatively small lesion of frontal cortex. The medial and lateral cortex can be selectively and differentially denervated of noradrenergic fibers, and there is a medial to lateral topographic relationship between deep longitudinally running fibers and overlying cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morrison, J H -- Molliver, M E -- Grzanna, R -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):313-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*physiology ; Gyrus Cinguli/physiology ; Nerve Fibers/*ultrastructure ; Norepinephrine/*physiology ; Pia Mater/physiology ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Albumin-deficient rat mutant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagase, S -- Shimamune, K -- Shumiya, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/*blood ; Chromosome Disorders ; Crosses, Genetic ; Female ; Immunoelectrophoresis ; Male ; Mutation ; Rats/*genetics ; Serum Albumin/*deficiency ; Serum Globulins/analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Calmodulin activation of adenylate cyclase in pancreatic islets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Fluorescent retrograde double labeling: axonal branching in the ascending raphe and nigral projections (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Red fluorescent Evans blue and blue fluorescent DAPI-primuline were injected into the anterior-medial and lateral-caudal forebrains, respectively, of the same rats. Separate clusters of cells labeled by retrograde transport were observed in the substantia nigra, while in the dorsal raphe many cells were double-labeled. Thus, single raphe cells send divergent axon collaterals to widespread forebrain areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Kooy, D -- Kuypers, H G -- New York, N.Y. -- Science. 1979 May 25;204(4395):873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441742" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping/methods ; Brain Stem/*cytology ; Cerebral Cortex/*cytology ; Fluorescent Dyes ; Neural Pathways/cytology ; Raphe Nuclei/*cytology ; Rats ; Substantia Nigra/*cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Semliki forest virus: cause of a fatal case of human encephalitis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: A fatal case of human encephalitis has been observed for which our results indicate that Semliki Forest virus (SFV) was the etiologic agent. This is surprising in view of the fact that this virus, which has been widely studied, was believed to be one of the arboviruses nonpathogenic for man. Described are the clinical course, the virological examinations performed, and the histopathological findings in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willems, W R -- Kaluza, G -- Boschek, C B -- Bauer, H -- Hager, H -- Schutz, H J -- Feistner, H -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1127-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424742" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antigens, Viral/analysis ; Arbovirus Infections/*etiology ; Encephalitis/*etiology/microbiology/pathology ; Female ; Humans ; Laboratory Infection/*etiology/microbiology ; *Semliki forest virus/immunology
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  • 94
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    Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing gamma-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zieglgansberger, W -- French, E D -- Siggins, G R -- Bloom, F E -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Endorphins/*pharmacology ; Enkephalins/*pharmacology ; Hippocampus/drug effects/*physiology ; Magnesium/pharmacology ; Neurons/drug effects/*physiology ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    The hyperactive child syndrome (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: The behavioral characteristics of the hyperactive child are described at different stages of development. Recent and sometimes controversial research findings are discussed with respect to prevalence, etiology, treatment, and outcome. It is concluded that this syndrome can best be understood in terms of interactions between social, psychological, and biological variables.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- Hechtman, L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1348-54.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472752" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Attention Deficit Disorder with Hyperactivity/etiology ; Child ; Child Behavior Disorders/diagnosis/*etiology/therapy ; Child, Preschool ; Environment ; Female ; Humans ; Infant ; Male ; Methylphenidate/therapeutic use ; Sex Ratio ; Syndrome ; Terminology as Topic
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  • 96
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    Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Horseradish peroxidase (HRP) in the presence of specific immunoglobulin G antibody to HRP is selectively absorbed from the gut lumen and transferred by intestinal epithelial cells to the lamina propria in newborn rats. The HRP is not transferred in detectable amounts in the absence of the antibody. Transport of maternally derived antigen via antigen-antibody complexes may have important influences on the developing immune system in young mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamson, D R -- Powers, A -- Rodewald, R -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):567-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; *Antigen-Antibody Complex ; *Antigens ; Biological Transport, Active ; Female ; Horseradish Peroxidase/immunology ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; *Intestinal Absorption ; Jejunum/*immunology/metabolism ; Male ; Rats
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  • 97
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baetens, D -- Malaisse-Lagae, F -- Perrelet, A -- Orci, L -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/390711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catheterization ; Glucagon/metabolism ; Insulin/metabolism ; Islets of Langerhans/*anatomy & histology/metabolism ; Pancreatic Polypeptide/metabolism ; Rats ; Somatostatin/metabolism
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  • 99
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Fetal research ethics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brackbill, Y -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504983" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; Disclosure ; *Ethics, Medical ; Female ; Fetus/*physiology ; Humans ; Informed Consent ; Pregnancy ; *Risk Assessment
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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