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  • Artikel  (120)
  • Pregnancy  (79)
  • Cell Line  (42)
  • 2010-2014
  • 1980-1984  (120)
  • 1950-1954
  • 1981  (62)
  • 1980  (58)
  • Science. 207(4426): 78-80.  (1)
  • Science. 207(4427): 199-201.  (1)
  • Science. 207(4427): 205-7.  (1)
  • Science. 207(4428): 315-7.  (1)
  • Science. 207(4428): 328-9.  (1)
  • Science. 207(4430): 527-8.  (1)
  • Science. 207(4431): 647-9.  (1)
  • Science. 207(4432): 771-3.  (1)
  • Science. 207(4432): 788-91.  (1)
  • Science. 207(4433): 902-4.  (1)
  • Science. 207(4434): 1008.  (1)
  • Science. 207(4435): 1083-5.  (1)
  • Science. 207(4437): 1296-7.  (1)
  • Science. 207(4437): 1323-5, 1327-8.  (1)
  • Science. 207(4437): 1367-9.  (1)
  • Science. 208(4439): 64-6.  (1)
  • Science. 208(4440): 183-5.  (1)
  • Science. 208(4440): 194-6.  (1)
  • Science. 208(4443): 505-8.  (1)
  • Science. 208(4443): 508-10.  (1)
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  • Artikel  (120)
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  • 2010-2014
  • 1980-1984  (120)
  • 1950-1954
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  • 1
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    Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-01
    Beschreibung: Newborn infants, chronically exposed in utero to low doses of methadone with or without concomitant heroin, display more rapid eye movement sleep and less quiet sleep than control infants, while babies fetally exposed to both opiates and nonopiates have less organization of sleep states. Other perinatal factors, such as birth weight and gestational age, are related more to the amount of fetal drug exposure than to the type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dinges, D F -- Davis, M M -- Glass, P -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):619-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190326" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Birth Weight ; Female ; Heroin/*adverse effects ; Heroin Dependence/drug therapy ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*chemically induced ; Maternal-Fetal Exchange ; Methadone/*adverse effects/therapeutic use ; Nervous System Diseases/*chemically induced ; Pregnancy ; Sleep/*drug effects ; Substance-Related Disorders
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-02
    Beschreibung: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Identical twins reared apart (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-03-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1323-5, 1327-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188816" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Environment ; Female ; Genetics, Medical ; Humans ; Intelligence ; Male ; Pregnancy ; Twins/*psychology ; Twins, Monozygotic/*psychology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Olfactory sensitivity in humans: genetic versus environmental control (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-09
    Beschreibung: Olfactory sensitivity to acetic acid, isobutyric acid, and 2-sec-butyl-cyclohexanone was tested in 97 adult male twin pairs to determine the extent to which variation in odor perception was genetically determined. Analysis of the data revealed no evidence for heritability of olfactory sensitivity. However, factors significantly associated with odor perception included cigar, pipe, and cigarette smoking; body fatness; alcohol consumption; and diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hubert, H B -- Fabsitz, R R -- Feinleib, M -- Brown, K S -- New York, N.Y. -- Science. 1980 May 9;208(4444):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189296" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetates ; Adult ; Alcohol Drinking ; Butyrates ; Cyclohexanones ; *Environment ; Female ; *Genes ; Humans ; Male ; Middle Aged ; Pregnancy ; Sensory Thresholds ; Skinfold Thickness ; Smell/*physiology ; Smoking ; *Twins ; Twins, Dizygotic ; Twins, Monozygotic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-11-21
    Beschreibung: Rats and guinea pigs, when immunized with mouse nerve growth factor, produce antibodies that cross-react with their own nerve growth factor. The antibodies reach developing offspring of these animals both prenatally (rats and guinea pigs) and postnatally (rats). Depriving the fetus of nerve growth factor in this way results in the destruction of up to 85 percent of dorsal root ganglion neurons as well as destruction of sympathetic neurons. Sensory neurons of placodal origin in the nodose ganglion were not affected. These data demonstrate that dorsal root ganglion neurons go through a phase of nerve growth factor dependence in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, E M Jr -- Gorin, P D -- Brandeis, L D -- Pearson, J -- HD12260/HD/NICHD NIH HHS/ -- HL20604/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):916-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7192014" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibodies ; Female ; Ganglia, Spinal/cytology/*embryology/growth & development ; Guinea Pigs ; Lactation ; Maternal-Fetal Exchange ; Milk/immunology ; Nerve Growth Factors/*immunology ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Maternal glucocorticoid hormones influence neurotransmitter phenotypic expression in embryos (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-31
    Beschreibung: Treatment of pregnant rats with reserpine prevented the normal disappearance of catecholamine fluorescence in presumptive neuroblasts of the embryonic gut. These cells normally express the noradrenergic phenotype transiently during embryonic development. The effect of reserpine was reproduced by treating mothers with hydrocortisone acetate. Moreover, the reserpine effect was blocked by treatment with dexamethasone, which inhibits the stress-induced increase in plasma glucocorticoids, and by mitotone, which causes adrenocortical cytolysis. It is concluded that reserpine, through the mediation of maternal glucocorticoid hormones, alters the phenotypic expression of these embryonic neuroblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonakait, G M -- Bohn, M C -- Black, I B -- HD 12108/HD/NICHD NIH HHS/ -- NS 06400/NS/NINDS NIH HHS/ -- NS 10259/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423206" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Catecholamines/metabolism ; Female ; Hydrocortisone/*pharmacology ; Intestines/*embryology/innervation ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Reserpine/*pharmacology ; Sympathetic Nervous System/*embryology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    High-molecular-weight immunoreactive beta-endorphin in extracts of human placenta is a fragment of immunoglobulin G (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-04-11
    Beschreibung: A high-molecular-weight protein with beta-endorphin- and adrenocorticotropin-immunoreactivities was isolated from extracts of human placenta after several purification steps, including immunoadsorption with a well-characterized antiserum raised to beta-endorphin. This protein was identified as the heavy chain of the human immunoglobulin class IgG1. These results have led to the recognition of homologies in the amino acid sequences of these physiologically unrelated molecules. They also suggest caution in accepting immunological competence as the sole criterion of the chemical identity of a ligand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Julliard, J H -- Shibasaki, T -- Ling, N -- Guillemin, R -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6244620" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Electrophoresis, Polyacrylamide Gel ; Endorphins/*analysis ; Female ; Humans ; Immunoglobulin G/*analysis ; Placental Extracts/*analysis ; Pregnancy ; Radioimmunoassay ; beta-Endorphin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    How safe is Bendectin? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):518-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423201" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abnormalities, Drug-Induced/*etiology ; Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Drug Evaluation ; Female ; Humans ; Jurisprudence ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Prenatal diagnosis fo neural tube defects (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-09-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Therapeutic/standards ; Female ; Genetic Diseases, Inborn ; Government Regulation ; Great Britain ; Humans ; Neural Tube Defects/*diagnosis ; Pregnancy ; *Pregnant Women ; *Prenatal Diagnosis ; Reagent Kits, Diagnostic ; Social Justice ; Spina Bifida Occulta/diagnosis ; United States ; Voluntary Programs ; alpha-Fetoproteins/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Local effect of the blastocyst on estrogen and progesterone receptors in the rat endometrium (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-03-07
    Beschreibung: Nuclear receptors for both estradiol and progesterone were present in twofold higher concentrations in implantation sites than in nonimplantation regions of the endometrium of 6-day pregnant rats. Decidualization in the absence of an embryo was not accompanied by a similar increase in the concentration of nuclear receptors. Moreover, this difference in receptor distribution between the implantation and nonimplantation areas persisted when a major part of the maternal supply of sex steroids was suppressed by ovariectomy on day 5 of pregnancy. These results support the hypothesis that steroids originating from the embryo affect the endometrial implantation site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logeat, F -- Sartor, P -- Hai, M T -- Milgrom, E -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355273" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blastocyst/*metabolism ; Castration ; Cell Nucleus/metabolism ; Decidua/metabolism ; Endometrium/*metabolism/ultrastructure ; Female ; Gestational Age ; Pregnancy ; Pseudopregnancy ; Rats ; Receptors, Estrogen/*metabolism ; Receptors, Progesterone/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    T-1 cells are HeLa and not of normal human kidney origin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson-Rees, W A -- Flandermeyer, R R -- Daniels, D W -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):719-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394535" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Chromosome Banding ; HLA Antigens/analysis ; HeLa Cells/*cytology/immunology ; Humans ; Karyotyping ; Kidney/*cytology/immunology ; Metaphase
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    alpha-Lactalbumin-casein induction in virgin mouse mammary explants: dose-dependent differential action of cortisol (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-03-21
    Beschreibung: The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ono, M -- Oka, T -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986657" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Caseins/*biosynthesis ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Hydrocortisone/*pharmacology ; Insulin/pharmacology ; Lactalbumin/*biosynthesis ; Mammary Glands, Animal/drug effects/*metabolism ; Mice ; Organ Culture Techniques ; Pregnancy ; Prolactin/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-07-11
    Beschreibung: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-02
    Beschreibung: A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parker, C R Jr -- Simpson, E R -- Bilheimer, D W -- Leveno, K -- Carr, B R -- MacDonald, P C -- New York, N.Y. -- Science. 1980 May 2;208(4443):512-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6445079" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Cortex/metabolism ; Adrenal Cortex Hormones/secretion ; Cholesterol/*blood ; Dehydroepiandrosterone/*analogs & derivatives/blood/metabolism ; Dehydroepiandrosterone Sulfate ; Female ; Fetal Blood/*analysis ; Humans ; Hypertension/metabolism ; Lipoproteins, LDL/*blood/metabolism ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy Complications, Cardiovascular/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-08
    Beschreibung: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-22
    Beschreibung: The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Membrane/metabolism ; Estradiol/blood ; *Estrus ; Feedback ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism ; Kinetics ; Luteinizing Hormone/blood ; Pituitary Gland, Anterior/*metabolism ; Pregnancy ; Progesterone/blood ; Rats ; Receptors, Cell Surface/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Genetic studies of an acardiac monster: evidence of polar body twinning in man (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-14
    Beschreibung: Two maternally derived chromosome sets and both maternal histocompatibility antigen haplotypes were identified in the tissues of a malformed triploid acardiac twin that developed within the same chorion as its normal twin. These findings indicate that the twins arose as a result of independent fertilizations, by two different spermatozoa, of a normal haploid ovum and its diploid first-meiotic-division polar body.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bieber, F R -- Nance, W E -- Morton, C C -- Brown, J A -- Redwine, F O -- Jordan, R L -- Mohanakumar, T -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196086" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abnormalities, Severe Teratoid/*genetics ; Female ; Fertilization ; HLA Antigens/genetics ; Heart Defects, Congenital/*genetics ; Humans ; Infant, Newborn ; Karyotyping ; Male ; Meiosis ; Polyploidy ; Pregnancy ; *Twins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    Cattle breeding (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 May 8;212(4495):610.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7194507" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cattle ; *Embryo Transfer ; Female ; Humans ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Familial studies of intelligence: a review (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-29
    Beschreibung: A summary of 111 studies identified in a survey of the world literature on familial resemblances in measured intelligence reveals a profile of average correlations consistent with a polygenic mode of inheritance. There is, however, a marked degree of heterogeneity of the correlations within familial groupings, which is not moderated by sex of familial pairing or by type of intelligence test used.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bouchard, T J Jr -- McGue, M -- 5 T32 MH14647/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 May 29;212(4498):1055-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7195071" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Family ; Female ; *Genetics, Medical ; Humans ; *Intelligence ; Intelligence Tests ; Male ; Pregnancy ; Sex Factors ; Twins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Rheumatoid factor-like immunoglobulin M protects previously uninfected rat pups and dams from Trypanosoma lewisi (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-09
    Beschreibung: The serum of lactating rats that have never been infected with the protozoan parasite Trypanosoma lewisi contains a rheumatoid factor-like immunoglobulin M (IgM). This IgM amplifies a specific immunoglobulin G (IgG) response to the parasite and accounts for the unusual resistance of previously uninfected lactating rats and their suckling pups to infection with T. lewisi. A similar rheumatoid factor-like IgM, which is induced late in the usual course of infection with T. lewisi in nonlactating rats, amplifies an earlier IgM response and terminates the infection. To our knowledge, this is the first description of a rheumatoid factor, which is classified as an autoimmune antibody, acting in a protective manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clarkson, A B Jr -- Mellow, G H -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7025211" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Suckling/immunology ; Antigen-Antibody Complex ; Female ; Immunoglobulin G ; Immunoglobulin M/*immunology ; *Lactation ; Pregnancy ; Rats ; Rheumatoid Factor/*immunology ; Trypanosoma lewisi/immunology ; Trypanosomiasis/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Effects of prenatal sex hormones on gender-related behavior (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-20
    Beschreibung: Gender identity depends largely on postnatal environmental influences, while sex-dimorphic behavior and temperamental sex differences appear to be modified by prenatal sex hormones. A role of the prenatal endocrine milieu in the development of erotic partner preference, as in hetero-, homo-, or bisexual orientation, or of cognitive sex differences has not been conclusively demonstrated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrhardt, A A -- Meyer-Bahlburg, H F -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1312-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209510" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adrenal Hyperplasia, Congenital/metabolism/psychology ; Adult ; Androgens/pharmacology ; Behavior/drug effects ; Child ; Cognition/drug effects ; Embryo, Mammalian/drug effects ; Estrogens/pharmacology ; Female ; *Gender Identity ; Gonadal Steroid Hormones/*pharmacology ; Humans ; *Identification (Psychology) ; Male ; Pregnancy ; Pregnancy Complications/drug therapy ; Progestins/pharmacology/therapeutic use ; Sexual Behavior/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-20
    Beschreibung: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-03
    Beschreibung: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 24
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    Fertilizability of ova ovulated and recovered from rabbit ovaries perfused in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-04
    Beschreibung: Ovaries removed from New Zealand White rabbits were perfused and exposed to gonadotropin in vitro. The ova ovulated in vitro (N = 56) were recovered and cultured and then transferred to the oviducts of six previously mated Dutch Belted hosts. Twelve of the resulting 36 offspring (33.3 percent) were white. In control matings between 12 Dutch Belted females (six randomly selected and the six hosts) and New Zealand White males, only one of 80 (1.2 percent) offspring was white. These data indicate that ova ovulated in vitro can be transferred to the oviduct of a host rabbit where they may be fertilized and after implantation may develop into viable embryos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kobayashi, Y -- Santulli, R -- Wright, K H -- Wallach, E E -- HD-05948/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1127-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268420" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chorionic Gonadotropin/*pharmacology ; Embryo Transfer ; Female ; *Fertilization in Vitro ; Ovary/drug effects/*physiology ; *Ovulation/drug effects ; Pregnancy ; Rabbits
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Insulin as a potent, specific growth factor in a rat hepatoma cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-02-27
    Beschreibung: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-03
    Beschreibung: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnani, J L -- Brockhaus, M -- Smith, D F -- Ginsburg, V -- Blaszczyk, M -- Mitchell, K F -- Steplewski, Z -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):55-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209516" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/*immunology ; Antibodies, Neoplasm/*immunology ; Antibody Specificity ; Antigens, Neoplasm/*immunology/isolation & purification ; Cell Line ; Chromatography, Thin Layer ; Colonic Neoplasms/*immunology ; Gangliosides/*immunology/isolation & purification ; Humans ; Melanoma/immunology ; Neuraminidase/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-04
    Beschreibung: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Brain tumors in children and occupational exposure of parents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-10
    Beschreibung: Ninety-two cases of brain tumor in children less than 10 years old were compared with 92 matched controls for parental occupational history. Cases were more likely than controls to show material occupations involving chemical exposure, paternal occupations involving solvents, and employment of father in the aircraft industry. These three factors were not affected by adjustment for the potential confounding variables examined in this study.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, F M -- Preston-Martin, S -- Yu, M C -- P01CA17054/CA/NCI NIH HHS/ -- R01CA20571/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244631" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/*adverse effects ; Air Pollutants, Occupational/*adverse effects ; Brain Neoplasms/*chemically induced ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; *Maternal-Fetal Exchange ; Pregnancy ; Respiration ; Risk ; Skin Absorption ; Solvents
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    Human lupus inclusions and interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-14
    Beschreibung: Raji cells, a human B lymphoblastoid cell line of Burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of Raji cells whose DNA thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. Ultracentrifugation of this medium in excess of that required to remove Epstein-Barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase destroyed the activity. These results demonstrate the presence of a protein that is secreted from bromodeoxyuridine-substituted Raji cells and is capable of inducing nonbromodeoxyuridine-substituted cells to form lupus inclusions. Interferon (100 units per milliliter) was found in the conditioned medium. Inclusions also formed in Raji cells grown in fresh medium supplemented with human leukocyte or fibroblast interferon (100 units per milliliter).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, S A -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):772-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6166984" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bromodeoxyuridine/*metabolism ; Burkitt Lymphoma ; Cell Line ; Culture Media ; Cytoplasmic Granules/ultrastructure ; DNA Replication ; Humans ; Interferons/*biosynthesis ; Lupus Erythematosus, Systemic/*pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Differentiation of respiratory and abortigenic isolates of equine herpesvirus 1 by restriction endonucleases (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: Viruses classified by immunologic criteria as equine herpesvirus 1 cause respiratory disease and abortion in horses. Restriction endonuclease analyses of the DNA's of viruses from animals with respiratory disease and from aborted fetuses show that the patterns for respiratory viruses, while similar to each other, are entirely different from the patterns for fetal viruses. It is therefore proposed that the DNA restriction endonuclease patterns of fetal and respiratory viruses analyzed in this study be designated as prototypic of equine herpesvirus 1 and 4, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Studdert, M J -- Simpson, T -- Roizman, B -- CA 08494/CA/NCI NIH HHS/ -- CA 09241/CA/NCI NIH HHS/ -- CA 19264/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):562-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270790" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Veterinary/*microbiology ; Animals ; DNA Restriction Enzymes ; DNA, Viral/genetics ; Female ; Fetus/microbiology ; Herpesviridae/*genetics ; Herpesvirus 1, Equid/*genetics ; Horse Diseases/*microbiology ; Horses ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 32
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    Amniocentesis: be prepared (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233217" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Induced ; *Amniocentesis ; Congenital Abnormalities/diagnosis ; Federal Government ; Female ; Humans ; Legislation, Medical ; Pregnancy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udeinya, I J -- Schmidt, J A -- Aikawa, M -- Miller, L H -- Green, I -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017935" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aotus trivirgatus ; Cells, Cultured ; Endothelium/microbiology ; Erythrocytes/*microbiology/ultrastructure ; Female ; Humans ; Microscopy, Electron ; Plasmodium falciparum/*pathogenicity ; Pregnancy ; Umbilical Veins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    Tumor cell killing by phorbol ester--differentiated human leukemia cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-07
    Beschreibung: The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, J B -- 27070-02/PHS HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196085" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation/drug effects ; Cell Line ; *Cytotoxicity, Immunologic ; Humans ; Immunity, Cellular ; Leukemia, Experimental/immunology/*pathology ; Macrophages/cytology/*immunology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-02-27
    Beschreibung: Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, J R -- Hodges, C A -- Black, A C Jr -- AA-03884/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):957-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466371" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abnormalities, Drug-Induced/*etiology ; Animals ; Ethanol/*pharmacology ; Female ; Hippocampus/abnormalities/drug effects/*embryology ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Resource partitioning during reproduction in the Norway rat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-02
    Beschreibung: Rat pups nursed by pregnant dams grow as fast as pups reared by dams that are not pregnant. Moreover, litters that were in utero during a lactation are as numerous at birth and grow as fast as pups developing in a nonlactating, pregnant mother. These litters continue to grow as fast as pups born to nonlactating dams whether or not the first litter remains after the birth of the second litter. When pregnant and lactating dams have a restricted food supply, some dams are capable of extending the duration of their pregnancies by over 2 weeks past that of nonlactating, pregnant dams. This facultative prolongation of pregnancy apparently allows females to carry normal litters to term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woodside, B -- Wilson, R -- Chee, P -- Leon, M -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):76-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444451" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/*physiology ; Energy Intake ; Energy Metabolism ; Female ; *Lactation ; Litter Size ; Pregnancy ; *Pregnancy, Animal ; Rats/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-26
    Beschreibung: The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yogeeswaran, G -- Salk, P L -- CA19312-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233237" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Membrane/*physiology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/*physiopathology ; Sialic Acids/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Abortion and the limitations of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zack, B G -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):291.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244615" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Spontaneous ; *Beginning of Human Life ; *Embryo, Mammalian ; Female ; Humans ; *Jurisprudence ; *Life ; *Personhood ; Pregnancy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Drug discrimination learning in lead-exposed rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-01
    Beschreibung: Lead acetate (0.02 or 0.5 percent) was administered to dams throughout the lactation period with half of the litters continuing on lead after weaning. Drug thresholds for d-amphetamine were determined by using the drug-discrimination learning paradigm. All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zenick, H -- Goldsmith, M -- New York, N.Y. -- Science. 1981 May 1;212(4494):569-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209554" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/drug effects ; Dextroamphetamine/*pharmacology ; Discrimination Learning/*physiology ; Disease Models, Animal ; Female ; Fetus/drug effects ; Lead Poisoning/*physiopathology ; Male ; Pregnancy ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 41
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    Health survey in high background radiation areas in China: High Background Radiation Research Group, China (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-08-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1980 Aug 22;209(4459):877-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403855" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Spontaneous/etiology ; China ; *Chromosome Aberrations ; Dose-Response Relationship, Radiation ; *Environmental Exposure ; Female ; Genetic Diseases, Inborn/*etiology ; Growth/radiation effects ; Humans ; *Maximum Allowable Concentration ; Neoplasms, Radiation-Induced/epidemiology/etiology ; Pregnancy ; *Radiation, Ionizing
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 42
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    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-02-08
    Beschreibung: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 43
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    Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-07-11
    Beschreibung: When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backer, J M -- Weinstein, I B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):297-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770466" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ; Animals ; Benzopyrenes/*metabolism ; Cell Line ; Cell Nucleus/metabolism ; DNA Replication/drug effects ; DNA, Mitochondrial/*metabolism ; Embryo, Mammalian ; Embryo, Nonmammalian ; L Cells (Cell Line) ; Liposomes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 44
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    Suckling (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-03
    Beschreibung: Suckling is the only behavior that is common among mammals. In newborn albino rats it is originally elicited by amniotic fluid deposited by the mother during parturition. Subsequent suckling is stimulated by saliva deposited on the nipples by the infant rats. Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension, milk, systemic dehydration, and intestinal hormone cholecystokinin suppress milk intake derived through suckling. The development of controls over suckling appetite appears to parallel that of consummatory control. Until about 2 weeks of age infant rats choose to suckle a nonlactating nipple with the same frequency as a lactating nipple. Thereafter, the lactating nipple is unanimously chosen. These studies suggest differences and commonalities in the suckling behavior of laboratory rats and other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blass, E M -- Teicher, M H -- AM-18560/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):15-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6997992" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Population Groups/*physiology ; Animals ; Animals, Suckling/*physiology ; Cholecystokinin/physiology ; Dehydration ; Feeding Behavior/physiology ; Female ; Food Deprivation ; Humans ; Instinct ; Lactation ; Lithium/pharmacology ; Maternal Behavior ; Pheromones ; Pregnancy ; Rats ; Saliva ; Sucking Behavior/drug effects/*physiology ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Does malnutrition affect fecundity? A summary of evidence (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-09
    Beschreibung: Moderate chronic malnutrition has only a minor effect on fecundity (reproductive capacity), and the resulting effect on fertility (actural reproduction) is very small. Among the fecundity components examined here in noncontracepting populations, age at menarche and the duration of lactational amenorrhea appear to be the ones most affected by malnutrition. But from neither of those effects can a difference in fertility of more than a few percent be expected between poorly and well-nourished women in developing countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bongaarts, J -- New York, N.Y. -- Science. 1980 May 9;208(4444):564-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367878" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Induced ; Adolescent ; Adult ; Age Factors ; Behavior ; Birth Intervals ; Contraception ; Female ; *Fertility ; Fetal Death/epidemiology ; Humans ; Lactation ; Male ; Marriage ; Menarche ; Menopause ; Middle Aged ; Nutrition Disorders/*physiopathology ; Nutritional Physiological Phenomena ; Ovulation ; Pregnancy ; Spermatogenesis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    The case of the unmentioned malignancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-12-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1229-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434022" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Cell Survival/radiation effects ; Cell Transformation, Neoplastic/radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; Neoplasms, Radiation-Induced/*etiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 47
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    Sparing of the brain in neonatal undernutrition: amino acid transport and incorporation into brain and muscle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-02-22
    Beschreibung: Rates of tyrosine and lysine transport and incorporation into protein were measured in control and undernourished weanling rats. Undernutrition was induced by feeding lactating dams a low protein diet (12 percent casein) from birth to day 21. At weaning, body and brain weights of undernourished rats were 50 percent and 88 percent, respectively, of control values. Lysine and tyrosine transport rates into skeletal muscle were reduced by over 75 percent, more than twice the reduction seen in brain. Rates of amino acid incorporation into muscle protein were reduced by approximately 50 percent; the change in rate of incorporation into brain protein was not statistically significant. These data indicate that, in spite of marked retardation of amino acid transport into brain, the brain seems fully capable of maintaining normal rates of protein synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freedman, L S -- Samuels, S -- Fish, I -- Schwartz, S A -- Lange, B -- Katz, M -- Morgano, L -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):902-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766565" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acids/*metabolism ; Animals ; Animals, Newborn/metabolism ; Biological Transport ; Body Weight ; Brain/growth & development/*metabolism ; Disease Models, Animal ; Female ; Lactation ; Male ; Muscles/*metabolism ; Pregnancy ; Protein-Energy Malnutrition/*metabolism ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 48
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    Diphenylhydantoin: pre- and postnatal administration alters diazepam binding in developing rat cerebral cortex (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-04-04
    Beschreibung: Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallager, D W -- Mallorga, P -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361107" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Benzodiazepines/metabolism ; Cerebral Cortex/*metabolism ; Diazepam/*metabolism ; Female ; Fetus/metabolism ; *Maternal-Fetal Exchange ; Phenytoin/administration & dosage/*pharmacology ; Pregnancy ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Endorphin-mediated increases in pain threshold during pregnancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-10
    Beschreibung: Maternal pain thresholds in rats were determined during various stages of pregnancy and parturition by measuring the intensity of electric shock that elicited reflexive jumping. There was a gradual rise in the pain threshold between 16 and 4 days prior to parturition and a more abrupt rise 1 to 2 days before that event. This increase was abolished by long-term administration of the narcotic antagonist naltrexone. The endorphin system is thus an important component of intrinsic mechanisms that modulate responsiveness to aversive stimuli. The data also demonstrate the activation during pregnancy of an endorphin system that is apparently quiescent in nonpregnant female rats treated the same way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- NIMH GRANT DA01771/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414330" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dose-Response Relationship, Drug ; Endorphins/antagonists & inhibitors/*physiology ; Female ; Naltrexone/pharmacology ; Pain/*physiopathology ; Pregnancy ; *Pregnancy, Animal ; Rats ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 50
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    Phenobarbital exposure in utero: alterations in female reproductive function in rats (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-02
    Beschreibung: Phenobarbital administration to pregnant rats from day 12 to day 19 of gestation suppressed body weight gain and produced significant effects on reproductive function in their offspring. These effects included delays in the onset of puberty, disorders in the estrous cycle, and infertility. Moreover, the animals exposed to phenobarbital in utero showed altered concentrations of sex steroids, gonadotrophic hormones, and estrogen receptors. These findings suggest that phenobarbital treatment during prenatal development can produce permanent alterations in sexual maturation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, C -- Sonawane, B R -- Yaffe, S J -- Shapiro, B H -- New York, N.Y. -- Science. 1980 May 2;208(4443):508-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367874" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Estrus/drug effects ; Female ; Luteinizing Hormone/blood ; Maternal-Fetal Exchange ; Phenobarbital/*adverse effects ; Pregnancy ; Rats ; Receptors, Estrogen/drug effects ; Reproduction/*drug effects ; Sexual Maturation/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 51
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    Vertebrate cells express protozoan antigen after hybridization (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-04-11
    Beschreibung: Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtained from the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crane, M S -- Dvorak, J A -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):194-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987737" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antigens/isolation & purification ; *Cell Fusion ; Cell Line ; Clone Cells ; Hybrid Cells/*immunology ; Hybridization, Genetic ; Mammals ; Polyethylene Glycols ; Trypanosoma cruzi/genetics/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Vertical transmission of acquired ulcer susceptibility in the rat (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-06-06
    Beschreibung: Premature separation of rat pups from their dams greatly increases their susceptibility to restraint-induced gastric erosions. When prematurely separated female rats grow to adulthood and mate with stock males, their normally reared F 1 progeny also have increased susceptibility to restraint-induced erosions. Cross-fostering studies show that prenatal rather than postnatal factors transmit this susceptibility to the F 1 progeny.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, N J -- Ackerman, S H -- Hofer, M A -- Weiner, H -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1161-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189606" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Suckling/physiology ; Female ; Humans ; Maternal Behavior ; Pregnancy ; Rats ; Restraint, Physical ; Stomach Ulcer/embryology/etiology/*genetics ; Stress, Psychological/*complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 53
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    Teratogenic effects of alcohol in humans and laboratory animals (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-07-18
    Beschreibung: The teratogenicity of alcohol has been demonstrated in humans through clinical studies, behavioral studies, and epidemiologic studies, and in animals through controlled laboratory experiments. In humans exposed to alcohol during gestation the effects can range from fetal alcohol syndrome in some offspring of chronic alcoholic women to reduced average birth weight in offspring of women reporting an average consumption of two to three drinks or more per day. The behavioral effects of such exposure may range from mental retardation in children with fetal alcohol syndrome to milder developmental and behavioral effects in infants born to social drinkers. In animals, exposure to alcohol in utero may result in death, malformation, and growth deficiency as well as behavioral and developmental abnormalities. The mechanisms of impairment and related risk factors are yet to be elucidated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streissguth, A P -- Landesman-Dwyer, S -- Martin, J C -- Smith, D W -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):353-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6992275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abnormalities, Drug-Induced ; Alcohol Drinking ; Brain/pathology ; Disease Models, Animal ; *Ethanol/pharmacology ; Female ; Fetal Alcohol Spectrum Disorders/*physiopathology ; Humans ; Hyperkinesis/chemically induced ; Infant, Low Birth Weight ; Infant, Newborn ; Pregnancy ; Sucking Behavior/drug effects ; *Teratogens
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 54
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    Suckling infant rats learn a preference for a novel olfactory stimulus paired with milk delivery (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-30
    Beschreibung: When presented a novel olfactory stimulus while suckling a passive dam, 11- to 14-day-old rat pups acquire a conditioned preference for that stimulus. The magnitude of the conditioned preference is greater if the pups received milk while suckling than if they did not. The results indicate that infants are capable of learning while suckling and that milk delivery plays a role in this associative process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brake, S C -- MH 32429/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):506-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7192882" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Population Groups/*physiology ; Animals ; Animals, Suckling/*physiology ; Association Learning/physiology ; Behavior, Animal/*physiology ; Conditioning (Psychology) ; Female ; *Lactation ; Pregnancy ; Rats ; Smell
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 55
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    Exposure of rats to alcohol in utero alters drug sensitivity in adulthood (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-26
    Beschreibung: Pregnant rats were intubated with alcohol (ethanol, 3 grams per kilogram) twice daily throughout gestation. Control animals received solutions of isocaloric sucrose. At birth, offspring were placed with untreated surrogate dams. Beginning at 6 months of age, the offspring were tested for their thermogenic responsiveness to various drugs and to cold. Prenatal exposure to alcohol resulted in tolerance to alcohol and cross-tolerance to pentobarbital and diazepam but did not affect responsiveness to cold. This pattern of effects suggest that prenatal exposure to alcohol produces specific long-term effects on the neural mechanisms underlying drug tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abel, E L -- Bush, R -- Dintcheff, B A -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1531-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233243" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chlorpromazine/pharmacology ; Dextroamphetamine/pharmacology ; Diazepam/pharmacology ; Drug Hypersensitivity ; Drug Tolerance ; Ethanol/*pharmacology ; Female ; Fetus/*drug effects ; Morphine/pharmacology ; Pentobarbital/pharmacology ; Pregnancy ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 56
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    Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: A biologically active rhodamine conjugate of thyrotropin binds at 4 degrees C to diffusely distributed membrane thyrotropin receptors which patch and become endocytosed into thyroid cells in a temperature-sensitive process. When the cells are first incubated with 8-bromo-cyclic adenosine monophosphate at 37 degrees C, the conjugate also binds to clustered receptors at 4 degrees C. Furthermore, 8-bromo-cyclic adenosine monophosphate reduces the amount of adenosine 3',5'-monophosphate (cyclic AMP) induced by thyrotropin. Hence, increased intracellular cyclic AMP induces receptor patching and reduces the concentration of cyclic AMP normally induced by thyrotropin. This suggests that cyclic AMP acts both as the second messenger of thyrotropin and also as the regulator of the level of thyrotropin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Avivi, A -- Tramontano, D -- Ambesi-Impiombato, F S -- Schlessinger, J -- CA-25820/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272396" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 8-Bromo Cyclic Adenosine Monophosphate ; Animals ; Cell Line ; Cell Membrane/drug effects/metabolism ; Cyclic AMP/*analogs & derivatives/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/drug effects/*metabolism ; Receptors, Thyrotropin ; Thyroid Gland/metabolism ; Thyrotropin/*metabolism/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 57
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    Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-10
    Beschreibung: Rats treated with chloramphenicol from days 7 to 21 of intrauterine life (50 milligrams per kilogram per day, injected subcutaneously into the mothers) or in the first 3 days of extrauterine life (50 to 100 milligrams per kilogram per day) were trained for avoidance conditioning when 60 days old. The acquisition of the avoidance response was impaired to a highly significant degree in all the treated groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertolini, A -- Poggioli, R -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):238-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244633" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging ; Animals ; Avoidance Learning/*drug effects ; Brain/drug effects/embryology/*growth & development ; Chloramphenicol/*pharmacology ; Female ; Male ; Maternal-Fetal Exchange ; Pregnancy ; Rats ; Sex Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 58
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    Heparin facilitates the extraction of tissue fibronectin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-13
    Beschreibung: Extraction of fibronectin from two human tissues, lung parenchyma and placental villi, was facilitated by the incorporation of heparin into extraction media. The effect of heparin was additive to the effect of urea which is known to extract fibronectin. These experiments provide further evidence that fibronectin and glycosaminoglycans are associated in connective tissues and the use of heparin forms the basis for a simple method for extraction and quantitation of tissue fibronectin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bray, B A -- Mandl, I -- Turino, G M -- HL 15832/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):793-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Dermatan Sulfate ; Female ; Fibronectins/*isolation & purification ; *Heparin ; Heparitin Sulfate ; Humans ; Lung/analysis ; Placenta/analysis ; Pregnancy ; Urea
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 59
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    Reduction in oocyte number following prenatal exposure to a diet high in galactose (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Y T -- Mattison, D R -- Feigenbaum, L -- Fukui, H -- Schulman, J D -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1145-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dietary Carbohydrates/*physiology ; Female ; Fetus/drug effects/physiology ; Galactose/*pharmacology ; Maternal-Fetal Exchange ; Oocytes/drug effects/*physiology ; Ovum/*physiology ; Pregnancy ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 60
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    Male vole urine changes luteinizing hormone-releasing hormone and norepinephrine in female olfactory bulb (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-01
    Beschreibung: Female prairie voles (Microtus ochrogaster) exposed to a single drop of male urine on the upper lip showed changes in concentrations of luteinizing hormone-releasing hormone (LHRH) and norepinephrine in olfactory bulb tissue; no such changes occurred in dopamine concentration. The changes were measured in the posterior but not the anterior olfactory bulb tissue of females within 1 hour after they were exposed to urine. These females also showed rapid increases in serum concentrations of luteinizing hormone. Females exposed to water on the upper lip showed none of these changes. These results suggest that in this species LHRH and norepinephrine in the olfactory bulb may mediate luteinizing hormone release in response to external (pheromonal) chemical cues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dluzen, D E -- Ramirez, V D -- Carter, C S -- Getz, L L -- HDO9328/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010608" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arvicolinae/*physiology ; Estrus ; Female ; Gonadotropin-Releasing Hormone/*metabolism ; Humans ; Luteinizing Hormone/blood ; Male ; Norepinephrine/*metabolism ; Olfactory Bulb/*metabolism ; Pheromones/*urine ; Pregnancy ; Reproduction ; Rodentia/*physiology ; Stress, Psychological/physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 61
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    Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-06
    Beschreibung: The etiologic agent of Korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. The cells, described as type II, alveolar epithelial, support replication of the agent and successive passages. Antigen of the Korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. Previous attempts to propagate this agent in vitro had been unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉French, G R -- Foulke, R S -- Brand, O A -- Eddy, G A -- Lee, H W -- Lee, P W -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1046-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6110243" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Viral/analysis ; Cell Line ; Hantavirus/*growth & development/immunology ; Hemorrhagic Fever with Renal Syndrome/*microbiology ; Humans ; Pulmonary Alveoli/microbiology ; RNA Viruses/*growth & development
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 62
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    Multiple paternity in Belding's ground squirrel litters (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-17
    Beschreibung: Sexually receptive female Spermophilus beldingi (Rodentia: Sciuridae) usually mate with several different males. The paternity of 27 litters born in 1977 and 1978 was ascertained by combining field observations of mating with laboratory paternity exclusion analyses. Most of the litters (78 percent) were multiply sired, usually by two or three males. This may be the highest frequency of multiple paternity ever directly demonstrated in a natural population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanken, J -- Sherman, P W -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):351-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209536" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Male ; Pregnancy ; Sciuridae/*physiology ; *Sexual Behavior, Animal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 63
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    Estradiol and progesterone profiles indicate a lack of endocrine recognition of pregnancy in the opossum (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-19
    Beschreibung: Concentrations of estradiol and progesterone in blood collected during the 12.5-day gestation period of the Virginia opossum were not significantly different from those during equivalent days of the estrous cycle. Progesterone was correlated with an index of corpora luteral mass. Ratio of estradiol to progesterone were highest 3 to 4 days before estrus and on the day of parturition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harder, J D -- Fleming, M W -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233228" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Corpus Luteum/physiology ; Estradiol/*blood ; Estrus ; Female ; Opossums/*physiology ; Pregnancy ; *Pregnancy, Animal ; Progesterone/*blood ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 64
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    Somatic cell hybrids from frog lymphocytes and mouse myeloma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-29
    Beschreibung: Stable somatic cell hybrids were obtained by fusing Xenopus lymphocytes with mouse myeloma cells. These hybrids contained one to four Xenopus chromosomes and expressed Xenopus gene products, one of which was a lymphocyte membrane protein of 85,000 daltons precipitated by a monoclonal antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hengartner, H -- Du Pasquier, L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1034-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies ; Antibodies, Monoclonal ; Cell Line ; Clone Cells ; Genes ; Hybrid Cells/*physiology ; Lymphocytes/*physiology ; Membrane Proteins/biosynthesis ; Mice ; Molecular Weight ; Neoplasms, Experimental/physiopathology ; Plasmacytoma/*physiopathology ; Xenopus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 65
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-01
    Beschreibung: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    Opiate withdrawal in utero increases neonatal morbidity in the rat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-22
    Beschreibung: Long-term oral administration of the long-acting opiate 1-alpha-acetylmethadol (LAAM) to female rats beginning on the day of conception interfered with the dams' ability to carry litters to term. When treatment was initiated 3 weeks prior to mating this effect was not observed. Daily administration of the opiate antagonist naloxone from day 14 of gestation through term, to precipitate withdrawal in utero, resulted in increased stillbirths, decreased pup weight and size, and weight loss 24 hours after birth. These data question the validity of animal experiments which purport to be models for methadone maintenance programs but in which treatment is started immediately prior to or soon after conception. They also suggest that withdrawal in utero may be responsible for many of the adverse effects of opiates on human and animal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lichtblau, L -- Sparber, S B -- DA 01880/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):943-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7195068" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Drug Tolerance ; Embryo Implantation/drug effects ; Female ; Fetal Death/*etiology ; Humans ; Litter Size/drug effects ; Methadone/*analogs & derivatives ; Methadyl Acetate/*adverse effects/antagonists & inhibitors ; Naloxone/pharmacology ; Opioid-Related Disorders/*complications ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Substance Withdrawal Syndrome/*complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 67
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    Owl monkey cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233214" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aotus trivirgatus ; Cell Line ; Hodgkin Disease/*pathology ; Humans ; Phenotype
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 68
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    Development of visual centers in the primate brain depends on binocular competition before birth (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rakic, P -- EY 02593/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):928-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302569" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/ultrastructure ; Brain/embryology/*growth & development ; Female ; Functional Laterality ; Geniculate Bodies/embryology/growth & development ; Macaca mulatta ; Microscopy, Electron ; Pregnancy ; Retina/physiology ; Synapses/physiology ; Visual Cortex/embryology/growth & development ; *Visual Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    Dissections and reconstructions of genes and chromosomes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, P -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):296-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264595" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chromosomes/*physiology/ultrastructure ; DNA Restriction Enzymes ; DNA, Recombinant ; DNA, Viral/genetics ; *Genes ; Histones ; Humans ; Plasmids ; RNA, Messenger/genetics ; Simian virus 40/genetics ; Transduction, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-16
    Beschreibung: Isolated hydra mesoglea served as a suitable substrate for the attachment and spreading of hydra cells in vitro, irrespective of the species tested. Hydra cells did not attach and spread on substrates typically used for culturing mammalian cells. Mammalian and Drosophila cells attached and spread on plastic culture dishes but not on isolated mesoglea. Xenopus epithelial cells spread on both plastic and mesoglea. Because of the similarities of hydra mesoglea to vertebrate basement membranes, suggestions are offered for using mesoglea to study the interactions of epithelial cells with their basement membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, R M -- Lenhoff, H M -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):291-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Basement Membrane/physiology ; Biological Evolution ; Cell Adhesion ; Cell Line ; Epithelial Cells ; Extracellular Space/physiology ; Hydra/*cytology ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kazmers, I S -- Mitchell, B S -- Dadonna, P E -- Wotring, L L -- Townsend, L B -- Kelley, W N -- AM 19045/AM/NIADDK NIH HHS/ -- CA 26032/CA/NCI NIH HHS/ -- CA 26284/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795718" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): B-Lymphocytes/enzymology ; Cell Line ; Deoxyguanosine/pharmacology ; Guanosine/*analogs & derivatives/pharmacology ; Humans ; Kinetics ; Pentosyltransferases/*antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/*antagonists & inhibitors ; T-Lymphocytes/drug effects/*enzymology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 72
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    Plasminogen activator release at the neuronal growth cone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-25
    Beschreibung: The site of plasminogen activator release by differentiated neuroblastoma clonal cell lines was determined with a fibrin overlay assay. Release of plasminogen activator was seen at the growth cone in 72 percent of the cells bearing neurites. For 21 percent of these cells the growth cone was the predominant or exclusive site of this enzyme activity. Selective release of protease at the "trailblazing" tip of the neurite may be important in neuron migration and neurite growth in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krystosek, A -- Seeds, N W -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1532-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Line ; *Cell Movement ; Cytochalasin B/pharmacology ; Fibroblasts/metabolism ; Mice ; Neuroblastoma ; Neurons/cytology/*enzymology ; Plasminogen Activators/*metabolism/secretion ; Secretory Rate/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Senate commences hearings on "human life" (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 May 8;212(4495):648-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221549" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Legal ; *Beginning of Human Life ; *Embryo, Mammalian ; *Embryo, Nonmammalian ; Federal Government ; Female ; Legislation as Topic ; *Life ; *Personhood ; Pregnancy ; United States ; Value of Life
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    Congress to reexamine antiabortion amendment (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):421.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244639" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Legal ; *Ethics, Medical ; Female ; Humans ; Legislation, Medical ; Pregnancy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Fetal female rats are masculinized by male littermates located caudally in the uterus (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-10
    Beschreibung: Female rats are masculinized in utero by male littermates sharing the same uterine horn. Increased anogenital distances in neonatal females and mounting behavior in adult females are related to the presence of males on the caudal side of the females in the uterine horn. Contrary to current beliefs, interamniotic diffusion may not be responsible for the exchange of masculinizing agents among fetuses. Since uterine blood flow in the rat is from the direction of the cervix toward the ovary, masculinizing hormones secreted by fetal males may be carried via the uterine vasculature to female littermates located further downstream.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meisel, R L -- Ward, I L -- HD-04688/HD/NICHD NIH HHS/ -- K2-MH00049/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):239-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244634" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Androgens/*physiology ; Animals ; Castration ; Estradiol/pharmacology ; Female ; Fetus/*physiology ; Male ; Posture ; Pregnancy ; Progesterone/pharmacology ; Rats ; *Sex Characteristics/drug effects ; Sexual Behavior, Animal/drug effects ; Uterus/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 76
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    High levels of intracellular bombesin characterize human small-cell lung carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moody, T W -- Pert, C B -- Gazdar, A F -- Carney, D N -- Minna, J D -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272398" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/analysis ; Bombesin/*analysis ; Carcinoma, Small Cell/*analysis ; Carcinoma, Squamous Cell/analysis ; Cell Line ; Humans ; Lung Neoplasms/*analysis ; Mesothelioma/analysis ; Peptides/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    Public health issues: bendectin, love canal (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paigen, B -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):6, 8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444447" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Female ; Humans ; New York ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects ; *Teratogens ; United States ; United States Food and Drug Administration ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 78
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    Studies support Bendectin safety claim (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1485.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015515" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antiemetics/*therapeutic use ; Clinical Trials as Topic ; Dicyclomine ; Doxylamine/*therapeutic use ; Drug Combinations/therapeutic use ; Female ; Humans ; Infant Mortality ; Infant, Newborn ; Pregnancy ; Pregnancy Complications/*drug therapy ; Pyridines/*therapeutic use ; Pyridoxine/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 79
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    Fetal alcohol syndrome: embryogenesis in a mouse model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-20
    Beschreibung: When two small doses of ethanol were administered to pregnant mice during the gastrulation stage of embryogenesis, the embryos developed craniofacial malformations closely resembling those seen in the human fetal alcohol syndrome. Striking histological changes appeared in the developing brain (neuroectoderm) within 24 hours of exposure. Decreased development of the neural plate and its derivatives apparently accounts for the craniofacial malformations. The critical exposure period is equivalent to the third week in human pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sulik, K K -- Johnston, M C -- Webb, M A -- DE 02668/DE/NIDCR NIH HHS/ -- DE 05906/DE/NIDCR NIH HHS/ -- RR 05333/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795717" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Child ; Disease Models, Animal ; Embryo, Mammalian/*drug effects/ultrastructure ; Ethanol/*pharmacology ; Eye Abnormalities ; Female ; Fetal Alcohol Spectrum Disorders/*physiopathology ; Humans ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron, Scanning ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-08
    Beschreibung: Normal pregnancies have been established in four women with tubal infertility by fertilization in vitro, embryo culture, and embryo transfer after stimulation of follicular growth with clomiphene citrate. In three of these women the time of oocyte maturation was controlled by human chorionic gonadotropin. This procedure for the control of ovulatory response has many advantages when compared with the previously successful method of using the natural ovulatory cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trounson, A O -- Leeton, J F -- Wood, C -- Webb, J -- Wood, J -- New York, N.Y. -- Science. 1981 May 8;212(4495):681-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221556" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chorionic Gonadotropin/*pharmacology ; Clomiphene/*pharmacology ; *Embryo Transfer ; Female ; *Fertilization in Vitro ; Humans ; Infertility, Female/therapy ; Ovulation/*drug effects ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Human life (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Jul 31;213(4507):494, 496.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244648" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Beginning of Human Life ; Ethics, Medical ; Female ; *Fertilization ; Fetus ; Humans ; *Life ; Male ; *Personhood ; Pregnancy ; Value of Life
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    "Human life" testimony (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Jul 10;213(4504):154-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244627" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Beginning of Human Life ; Ethics ; Female ; *Fertilization ; Humans ; *Life ; Male ; Ovum/physiology ; *Personhood ; Pregnancy ; Spermatozoa/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    The development of human fetal eye movement patterns (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-07
    Beschreibung: The eye can be visualized ultrasonically in more than 90 percent of fetuses 16 through 42 weeks of gestational age. Slow eye movements are present by 16 weeks. Rapid eye movements begin at 23 weeks and become more frequent between 24 and 35 weeks. Eye inactivity becomes more common after 36 weeks and is associated with sustained diaphragmatic excursions implying a "quiet sleep" state. Pathologic eye movements were seen in four fetuses with dysmorphic brain structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnholz, J C -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):679-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256272" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Brain/abnormalities/embryology ; Eye/*embryology ; *Eye Movements ; Female ; Gestational Age ; Humans ; Pregnancy ; Sleep/physiology ; Ultrasonics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    Induction of hemoglobin accumulation in human K562 cells by hemin is reversible (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-24
    Beschreibung: Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in K562 cells does not depend on irreversible differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dean, A -- Erard, F -- Schneider, A P -- Schechter, A N -- AM 00103/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163216" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Differentiation/drug effects ; Cell Line ; Fetal Hemoglobin/biosynthesis ; Gene Expression Regulation/drug effects ; Heme/*analogs & derivatives ; Hemin/*pharmacology ; Hemoglobins/*biosynthesis ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    Integration and stable germ line transmission of genes injected into mouse pronuclei (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: Genetic material has been successfully transferred into the genomes of newborn mice by injection of that material into pronuclei of fertilized eggs. Initial results indicated two patterns of processing the injected DNA: one in which the material was not integrated into the host genome, and another in which the injected genes became associated with high molecular weight DNA. These patterns are maintained through further development to adulthood. The evidence presented indicates the covalent association of injected DNA with host sequences, and transmission of such linked sequences in a Mendelian distribution to two succeeding generations of progeny.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, J W -- Ruddle, F H -- GMO7959-01/GM/NIGMS NIH HHS/ -- GMO9966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1244-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272397" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Nucleus/*metabolism ; Crosses, Genetic ; DNA Restriction Enzymes ; DNA, Recombinant/*metabolism ; Embryo, Mammalian/*physiology ; Female ; *Genes ; Genetic Linkage ; Herpesviridae/enzymology ; Male ; Mice ; Nucleic Acid Hybridization ; Ovum/*physiology ; *Plasmids ; Pregnancy ; Sex Ratio ; Simian virus 40/enzymology ; Thymidine Kinase/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 86
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    Fetal alcohol advisory debated (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):642-3, 645.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197392" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Spontaneous/chemically induced ; *Ethanol ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Pregnancy ; Pregnancy Complications/*chemically induced
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    Ureaplasma urealyticum incriminated in perinatal morbidity and mortality (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-24
    Beschreibung: Perinatal morbidity and mortality are associated with colonization of the chorionic surface of the placenta by Ureaplasma urealyticum or Mycoplasma hominis or both. These organisms are more strongly associated with unfavourable gestational outcome than group B streptococci. Chlamydia trachomatis does not appear to be important in the etiology of reproductive casualties. The mechanisms linking the mycoplasmas to perinatal disorders and death are not clear but merit investigation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kundsin, R B -- Driscoll, S G -- Pelletier, P A -- HD 10984/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):474-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244646" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Critical Care ; Female ; *Fetal Death ; Humans ; *Infant Mortality ; Infant, Newborn ; Infant, Newborn, Diseases/*microbiology ; Mycoplasma/*pathogenicity ; Mycoplasma Infections/*complications ; Placenta/microbiology ; Pregnancy ; Ureaplasma/*pathogenicity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    Estrogen receptors in the nidatory sites of the rat endometrium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-27
    Beschreibung: In ovariectomized rats treated with progesterone, implantation was induced by a minute dose of 17 beta-estradiol. Twenty-four hours later, the concentrations of estradiol receptor in nuclear and cytosol fractions prepared from the endometrium surrounding the blastocyst and the inter-implantation areas remained very low. This indicates that estrogen was not secreted by the blastocyst. The higher receptor content in cytosol from inter-implantation sites may reflect modifications accompanying the decidual reaction since our results show that there is no translocation of the receptor to the nuclei. The choice of the dye used to reveal the implantation sites is critical, since Trypan blue but not Evans blue binds steroids and thereby interferes with receptor measurements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martel, D -- Psychoyos, A -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1454-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466405" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blastocyst/secretion ; Castration ; Cell Nucleus/analysis ; Cytoplasm/analysis ; *Embryo Implantation ; Endometrium/*analysis ; Estradiol/pharmacology ; Estrogens/secretion ; Evans Blue/metabolism ; Female ; Pregnancy ; Progesterone ; Rats ; Receptors, Estrogen/*analysis ; Trypan Blue/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    Warburg effect revisited: merger of biochemistry and molecular biology (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Racker, E -- Spector, M -- CA-08964/CA/NCI NIH HHS/ -- CA-14454/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):303-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264596" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphatases/*metabolism ; Animals ; Avian Sarcoma Viruses/metabolism ; Brain/*enzymology ; Carcinoma, Ehrlich Tumor/*metabolism ; Cell Line ; Cell Transformation, Neoplastic ; Electric Organ/enzymology ; Electrophorus ; *Glycolysis/drug effects ; Macromolecular Substances ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Ouabain/pharmacology ; Oxidation-Reduction ; Polyomavirus/metabolism ; Protein Kinases/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Superovulation and embryo transfer in cattle (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-23
    Beschreibung: About 17,000 bovine pregnancies were produced by superovulation and embryo transfer in North America in 1979. The major use of these techniques is to increase the reproductive rate of valuable cows. Other applications include circumventing infertility, exporting embryos, and testing potential carriers for Mendelian recessive alleles. Cryopreservation of embryos is beginning to be used commercially, and sexing embryos before transfer may soon become routine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidel, G E Jr -- New York, N.Y. -- Science. 1981 Jan 23;211(4480):351-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7194504" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Husbandry/*methods ; Animals ; Cattle/*physiology ; *Embryo Transfer ; Female ; Industry ; *Ovulation ; Pregnancy ; *Pregnancy, Animal ; Reproduction ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    Human life bill arouses more opposition (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1372-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233224" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Induced ; *Ethics, Medical ; Federal Government ; Female ; Humans ; Legislation, Medical ; Personhood ; Pregnancy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    Impaired brain growth in neonatal rats exposed to ethanol (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-16
    Beschreibung: Infant rat pups, fed through intragastric cannulas from postnatal day 4 through day 18, showed a 19 percent reduction in total brain weight when ethanol was included in their diet on days 4 through 7. This reduction in brain weight occurred even though body growth in the experimental rats was equal to that of their littermate controls. The ethanol-exposed animals were markedly hypoactive during the period of drug administration, then displayed gross body tremors for 3 to 5 days. Throughout the study, the animals treated with ethanol had poor motor coordination and were hyperresponsive. These brain and behavioral effects appear similar to those seen in fetal alcohol syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diaz, J -- Samson, H H -- New York, N.Y. -- Science. 1980 May 16;208(4445):751-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189297" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Age Factors ; Animals ; Animals, Newborn ; Behavior, Animal/physiology ; Brain/anatomy & histology/drug effects/*growth & development ; Cerebellum/growth & development ; Disease Models, Animal ; Ethanol/*pharmacology ; Female ; Fetal Alcohol Spectrum Disorders/*embryology ; Organ Size ; Pregnancy ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 93
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    Asymmetrically permeable membrane channels in cell junction (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-02-15
    Beschreibung: Asymmetric membrane junctions were formed in culture by pairing two cell types which, in their respective homologous junctions, have cell-cell channels of different permselectivities. The channels in the asymmetric junction, presumably made of unequal channel precursors, displayed directional permselectivity; fluorescent labeled glutamic acid (700 daltons), but not smaller and less polar permeant molecules, traversed the junction more readily in one direction than in the other. The favored direction was the one where the permeant passed first through the cell membrane that would have the less restrictive channels in a homologous junction. This directional selectivity requires no electric field across the junction and is thus distinct from a rectifying junction. The physiological potential of such directional molecular sieving for partitioning communication between tissue cells of different function and developmental fate are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J L -- Loewenstein, W R -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352287" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Transport ; *Cell Communication ; Cell Line ; Cell Membrane Permeability ; Fluorescent Dyes ; Intercellular Junctions/*physiology ; Ion Channels/*physiology/ultrastructure ; Membrane Potentials ; Mice
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 94
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    Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-01
    Beschreibung: Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harden, T K -- Cotton, C U -- Waldo, G L -- Lutton, J K -- Perkins, J P -- GM 25163/GM/NIGMS NIH HHS/ -- HL 22490/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct;210(4468):441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254143" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenylyl Cyclases/metabolism ; Astrocytoma ; Cell Line ; Centrifugation, Density Gradient ; Concanavalin A/pharmacology ; Endocytosis ; Humans ; Isoproterenol/*metabolism ; Protein Conformation ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 95
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    Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-06-13
    Beschreibung: Injection of iodine-131-labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumor/nontumor ration of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Kim, E E -- DeLand, F H -- van Nagell, J R Jr -- Javadpour, N -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1284-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375942" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies/*administration & dosage ; Choriocarcinoma/*radionuclide imaging ; Chorionic Gonadotropin/*immunology ; Female ; Humans ; Hydatidiform Mole/*radionuclide imaging ; Immunoglobulin G/administration & dosage ; Pregnancy ; Radioimmunoassay/methods ; Radionuclide Imaging/methods ; Teratoma/*radionuclide imaging ; Uterine Neoplasms/*radionuclide imaging
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
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    Carcinogenic activity of particulate nickel compounds is proportional to their cellular uptake (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-07-25
    Beschreibung: Particles (less than or equal to 5 micrometers) of the potent carcinogen crystalline nickel subsulfide were actively phagocytized by cultures of Syrian hamster embryo cells and Chinese hamster ovary cells. Cells did not take up significant quantities of similar-sized particles of the noncarcinogen amorphous nickel monosulfide. The carcinogenic activity of this and other metal compounds appears to be proportional to their cellular uptake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costa, M -- Mollenhauer, H H -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):515-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394519" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Transport ; *Carcinogens ; Cell Line ; Cricetinae ; Cricetulus ; Drug Evaluation, Preclinical/methods ; Embryo, Mammalian ; Female ; Mesocricetus ; Nickel/*metabolism/toxicity ; Ovary ; Sulfides/metabolism/toxicity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
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    Placental beta-endorphin-like peptides (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-01-04
    Beschreibung: Acid extract of human placental tissue contain, by both radioimmunoassay and radioreceptor assay, beta-endrophin-like material. Half of this material will not go through a 5000-dalton filter and on Sephadex G-200 has a molecular size between 25,00 and 50,000 daltons. Of the material going through a 5000-dalton ultrafilter, 80 percent is excluded on Sephadex G-25 and held back, very slightly, on Bio-Rad P6, indicating a molecular size of approximately 4500 to 4800 daltons. Thus, placenta appears to have macromolecular precursors from which a beta-endorphin-like material is released, with a size approximately 12 amino acids longer than half of the pituitary hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Houck, J C -- Kimball, C -- Chang, C -- Pedigo, N W -- Yamamura, H I -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):78-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350643" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Endorphins/*metabolism ; Female ; Humans ; Molecular Weight ; Placenta/*metabolism ; Pregnancy ; Radioimmunoassay ; Radioligand Assay
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
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    Cell variants showing differential susceptibility to ultraviolet light--induced transformation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-07-25
    Beschreibung: Six variant clones isolated from a subclone of BALB/3T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kakunaga, T -- Crow, J D -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394516" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic/*radiation effects ; Clone Cells ; Dose-Response Relationship, Radiation ; Genetic Variation ; Mice ; Transformation, Genetic/*radiation effects ; *Ultraviolet Rays
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
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    Placental luteinizing hormone-releasing factor and its synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-01-18
    Beschreibung: The synthesis of a placental luteinizing hormone-releasing factor (pLRF), which is immunologically, physiochemically, and biologically indistinguishable from synthetic LRF, was demonstrated. The incorporation of 3H-labeled leucine by human placental tissue in vitro into pLRF was determined by purification on carboxymethyl-cellulose and specific immunoprecipitation of the 3H-labeled pLRF. The specific activity of the pLRF released into the medium increased 100-fold from day 1 to day 2 of culture and attained a concentration of 2.84 microcuries per microgram. These data indicate that the pLRF that was released initially was endogenous, whereas that released subsequently reflected synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khodr, G S -- Siler-Khodr, T M -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985750" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Culture Techniques ; Female ; Gonadotropin-Releasing Hormone/biosynthesis/immunology/*metabolism ; *Hormones ; Humans ; Placenta/*metabolism ; Pregnancy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    Nursing frequency, gonadal function, and birth spacing among !Kung hunter-gatherers (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-02-15
    Beschreibung: Mothers among !Kung hunter-gatherers nurse briefly and frequently, with brief intervals between nursing bouts (mean +/- standard error, 13.19 +/- 1.28 minutes). The low levels of 17 beta-estradiol and progesterone in the serum of the mother are correlated with infant's age and with interbout interval, but not with total nursing time. Maternal gonadal function is apparently suppressed by a timing-dependent, prolactin-mediated effect of breast stimulation. Interbout interval may be a key variable in lactation infertility. If so, it solves the puzzle of !Kung birth spacing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Konner, M -- Worthman, C -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):788-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352291" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amenorrhea/*etiology ; *Birth Intervals ; Botswana ; Estradiol/blood ; Female ; Humans ; *Lactation ; *Maternal Behavior ; Menstruation ; Namibia ; *Postpartum Period ; Pregnancy ; Progesterone/blood
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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